MCID: CRD003
MIFTS: 42

Cardiac Sarcoidosis

Categories: Immune diseases

Aliases & Classifications for Cardiac Sarcoidosis

MalaCards integrated aliases for Cardiac Sarcoidosis:

Name: Cardiac Sarcoidosis 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:13405
NCIt 50 C35589
SNOMED-CT 68 75403004
UMLS 72 C0392077

Summaries for Cardiac Sarcoidosis

Disease Ontology : 12 A sarcoidosis that is characterized by conduction abnormalities, arrhythmias, and congestive heart failure with noncaseating granulomas present on endomyocardial biopsy, and develops from a type IV hypersensitivity reaction with noncaseating granulomas infiltrating the myocardial tissue, especially that of the left ventricle.

MalaCards based summary : Cardiac Sarcoidosis is related to pericarditis and autoimmune disease. An important gene associated with Cardiac Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Fluorodeoxyglucose F18 and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Cardiac Sarcoidosis

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 pericarditis 29.9 TNF IFNG
2 autoimmune disease 29.5 TNF IFNG HLA-DQB1
3 toxic shock syndrome 29.4 TNF IFNG CXCL8
4 ulcerative colitis 29.4 TNF IFNG CXCL8
5 sarcoidosis 1 11.2
6 atrioventricular block 10.7
7 cardiac conduction defect 10.6
8 congestive heart failure 10.5
9 myocarditis 10.5
10 exudative glomerulonephritis 10.5 TNF CXCL8
11 tungiasis 10.5 TNF CXCL8
12 streptococcal toxic-shock syndrome 10.5 TNF CXCL8
13 haemophilus influenzae 10.5 TNF CXCL8
14 opisthorchiasis 10.5 TNF CXCL8
15 mycobacterium abscessus 10.4 TNF CXCL8
16 dilated cardiomyopathy 10.4
17 louse-borne relapsing fever 10.4 TNF CXCL8
18 epstein-barr virus-associated gastric carcinoma 10.4 TNF PSMB9
19 periodontosis 10.4 TNF CXCL8
20 beryllium disease 10.4 TNF HLA-DQB1
21 dental pulp disease 10.4 TNF CXCL8
22 endometrial disease 10.4 TNF CXCL8
23 transverse myelitis 10.4 TNF CXCL8
24 arrhythmogenic right ventricular cardiomyopathy 10.4
25 pulmonary sarcoidosis 10.4
26 atrial standstill 1 10.4
27 tuberculous meningitis 10.4 TNF CXCL8
28 idiopathic achalasia 10.4 TNF HLA-DQB1
29 pyoderma 10.4 TNF CXCL8
30 pyoderma gangrenosum 10.4 TNF CXCL8
31 pulpitis 10.4 TNF CXCL8
32 middle ear disease 10.4 TNF CXCL8
33 progressive familial heart block, type ia 10.4
34 bacterial sepsis 10.4 TNF CXCL8
35 sialadenitis 10.4 TNF HLA-DQB1
36 fasciitis 10.4 TNF CXCL8
37 oligoarticular juvenile idiopathic arthritis 10.4 TNF HLA-DQB1
38 perinatal necrotizing enterocolitis 10.4 TNF CXCL8
39 stromal keratitis 10.4 TNF CCR6
40 pustulosis palmaris et plantaris 10.3 TNF CCR6
41 viral encephalitis 10.3 TNF CXCL8
42 endometritis 10.3 TNF HLA-DQB1
43 geographic tongue 10.3 TNF HLA-DQB1
44 acute respiratory distress syndrome 10.3 TNF CXCL8
45 staphylococcal toxic shock syndrome 10.3 TNF IFNG
46 autoimmune myocarditis 10.3 TNF IFNG
47 prostatitis 10.3 TNF CXCL8
48 panuveitis 10.3 TNF HLA-DQB1
49 trichosporonosis 10.3 TNF IFNG
50 scleritis 10.3 TNF IFNG

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to Cardiac Sarcoidosis

Symptoms & Phenotypes for Cardiac Sarcoidosis

GenomeRNAi Phenotypes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 CXCL8 HLA-DQB1 PSMB8 PSMB9 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 CXCL8 HLA-DQB1 PSMB8 PSMB9 TNF

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCR6 HLA-DQB1 IFNG IL12B PSMB8 PSMB9
2 immune system MP:0005387 9.5 CCR6 HLA-DQB1 IFNG IL12B PSMB8 PSMB9
3 neoplasm MP:0002006 9.02 IFNG IL12B PSMB8 PSMB9 TNF

Drugs & Therapeutics for Cardiac Sarcoidosis

Drugs for Cardiac Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorodeoxyglucose F18 Phase 4
2 Radiopharmaceuticals Phase 4
3
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
4
leucovorin Approved Phase 3 58-05-9 143 6006
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
6 Hematinics Phase 2, Phase 3
7 Pharmaceutical Solutions Phase 2, Phase 3
8 Parenteral Nutrition Solutions Phase 2, Phase 3
9 Ferrosoferric Oxide Phase 2, Phase 3
10 Antirheumatic Agents Phase 3
11 Folic Acid Antagonists Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13 Vitamin B Complex Phase 3
14 Vitamin B9 Phase 3
15 Folate Phase 3
16 Immunosuppressive Agents Phase 3
17 Dermatologic Agents Phase 3
18 Immunologic Factors Phase 3
19 Antimetabolites, Antineoplastic Phase 3
20 Antimetabolites Phase 3
21 Interleukin 1 Receptor Antagonist Protein Phase 2
22
Prednisolone phosphate Approved, Vet_approved 302-25-0
23
Methylprednisolone hemisuccinate Approved 2921-57-5
24
Methylprednisolone Approved, Vet_approved 83-43-2 6741
25
Prednisolone Approved, Vet_approved 50-24-8 5755
26
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605
27
Prednisolone hemisuccinate Experimental 2920-86-7
28 Gastrointestinal Agents
29 Antiemetics
30 Neuroprotective Agents
31 Peripheral Nervous System Agents
32 Methylprednisolone Acetate
33 Protective Agents
34 Autonomic Agents
35 Prednisolone acetate

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis Recruiting NCT03549598 Phase 4 68Ga-DOTATATE PET/CT;18FDG PET/CT scan;13NH3 PET/CT scan
2 CArdiac Sarcoidosis Response TO steRoids (CASTOR) Trial Withdrawn NCT01210677 Phase 4 Prednisone
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
4 Cardiac Sarcoidosis Multi-Center Randomized Controlled Trial Recruiting NCT03593759 Phase 3 Prednisone;Methotrexate
5 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Myocardial Perfusion Imaging for Evaluation of Cardiac Sarcoidosis Completed NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
6 18F-FSPG PET/MRI or PET/CT Imaging of Cardiac Sarcoidosis or Inflammation Recruiting NCT03103490 Phase 2 18F-FSPG
7 Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis Not yet recruiting NCT04017936 Phase 2 Anakinra;Placebos
8 Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications Unknown status NCT02062008
9 Sub-project: Use of Small Implantable ECG Recorder in Pregnant Women With Arrhythmia Unknown status NCT02249195
10 [18 F]-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET) in Cardiac Sarcoidosis Approved for marketing NCT01764191
11 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Completed NCT02546388 Indium-111 Pentreotide
12 Diagnosing Cardiac Sarcoidosis Using FDG PET: Optimization Completed NCT01729169
13 18F-fluorodeoxyglucose Positron Emission Tomography Imaging in Cardiac Sarcoidosis Reveals Characteristic Heterogeneity of Tracer Uptake and the Disease Activity in Myocardium Completed NCT00958087
14 Efficacy if Implantable Cardioverter Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis Completed NCT01013311
15 Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis Completed NCT01648933
16 Somatostatin Receptor Imaging in Cardiac Sarcoidosis Recruiting NCT02812849 Cu-64 DOTATATE
17 A Randomized Screening Trial for Cardiac Sarcoidosis (CS) in Patients Seen During Routine Clinical Care Who Have Not Been Clinically Suspected to Have (CS), Comparing the Addition of Echocardiogram and Ambulatory ECG to Standard of Care. Recruiting NCT03902223
18 Molecular Imaging in Cardiovascular Disease Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR): Cardiac Sarcoidosis Recruiting NCT03705884 Prednisolone
19 Feasibility and Accuracy of Hybrid Magnetic Resonance and Positron Emission Tomography With 18F-Fluorodeoxyglucose in Diagnosing Cardiac Sarcoidosis Recruiting NCT03923049
20 Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis: A Pilot Study Combining Advanced MRI and 18F-FDG and 18F-GE180 PET of the Myocardium Recruiting NCT03561025
21 Cardiac Sarcoidosis Multi-Center Prospective Cohort Study Recruiting NCT01477359
22 Diagnostic and Prognostic Significance of Combined PET/MRI in Inflammatory Cardiomyopathies and Sarcoidosis Recruiting NCT03356756
23 Detection and Prognostic Significance of Myocardial Damage Visualized by Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis Recruiting NCT01745237
24 Evaluation of 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging in Myocarditis Recruiting NCT03777839
25 CASPA (CArdiac Sarcoidosis in PApworth): Improving the Diagnosis of Cardiac Disease in Patients With Pulmonary Sarcoidosis Recruiting NCT03599414
26 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC - a Feasibility Study Recruiting NCT02989480
27 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Active, not recruiting NCT03746847 Gallium-68 DOTATATE
28 Cardiomyocyte Specific Cell Free DNA as a Marker of Cardiac Sarcoidosis Not yet recruiting NCT03858777
29 Non-Invasive Characterization in Cardiac Sarcoidosis Terminated NCT02017522

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

MalaCards organs/tissues related to Cardiac Sarcoidosis:

41
Heart, Testes, Lung, Lymph Node, Kidney, T Cells, Monocytes

Publications for Cardiac Sarcoidosis

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 1154)
# Title Authors PMID Year
1
Assessment of myocardial viability by PET. 38
31393420 2019
2
Assessment of the 2017 AHA/ACC/HRS Guideline Recommendations for Implantable Cardioverter-Defibrillator Implantation in Cardiac Sarcoidosis. 38
31431050 2019
3
Treatment of cardiac sarcoidosis. 38
31365386 2019
4
Advanced sarcoidosis. 38
31365384 2019
5
Comparison of Clinical and Morphologic Findings in Patients With Cardiac Sarcoidosis Severe Enough to Warrant Heart Transplantation in Those With -vs- Those Without Non-Caseating Granulomas in the Explanted Heart (Burnt-Out Sarcoid). 38
31235064 2019
6
The role of positron emission tomography in the assessment of cardiac sarcoidosis. 38
31166768 2019
7
Letter by Birnie et al Regarding Article, "Diagnostic Accuracy of Advanced Imaging in Cardiac Sarcoidosis: Implications for the Diagnosis of Isolated Cardiac Sarcoidosis". 38
31412720 2019
8
Cardiac sarcoidosis in monozygotic twins: An opportunity for early surveillance and treatment. 38
31389041 2019
9
Diagnostic Specificity of Basal Inferoseptal Triangular Late Gadolinium Enhancement for Identification of Cardiac Sarcoidosis. 38
31422121 2019
10
Imaging Cardiac Sarcoidosis With FLT-PET Compared With FDG/Perfusion-PET: A Prospective Pilot Study. 38
31422126 2019
11
Left atrial involvement of cardiac sarcoidosis manifesting as left atrial re-entrant tachycardia. 38
30919889 2019
12
Clinical Features and Histopathology of Cardiac Sarcoidosis with Refractory Heart Failure: An Autopsy Case. 38
31434823 2019
13
Case of isolated cardiac sarcoidosis diagnosed by newly developed abnormal uptake during serial follow-up fluorine-18 fluorodeoxyglucose positron emission tomography. 38
31264810 2019
14
Recommendations for 18F-fluorodeoxyglucose positron emission tomography imaging for diagnosis of cardiac sarcoidosis-2018 update: Japanese Society of Nuclear Cardiology recommendations. 38
31197741 2019
15
Response by Divakaran et al to Letter Regarding Article, "Diagnostic Accuracy of Advanced Imaging in Cardiac Sarcoidosis: An Imaging-Histologic Correlation Study in Patients Undergoing Cardiac Transplantation". 38
31412718 2019
16
Severe left ventricular systolic dysfunction after permanent pacemaker implantation: Should we pause before upgrading to biventricular pacing? 38
31233835 2019
17
Prognosis and risk stratification in cardiac sarcoidosis patients with preserved left ventricular ejection fraction. 38
31277963 2019
18
Repeatability and Optimization of FDG Positron Emission Tomography for Evaluation of Cardiac Sarcoidosis. 38
30846271 2019
19
Regional abnormalities on cardiac magnetic resonance imaging and arrhythmic events in patients with cardiac sarcoidosis. 38
31328324 2019
20
Cardiac magnetic resonance imaging to predict arrhythmic events in cardiac sarcoidosis: Unmasking the great pretender? 38
31332847 2019
21
Recurrent polymorphic ventricular tachycardia initiated by Purkinje ectopy in a patient with cardiac sarcoidosis. 38
31341777 2019
22
Somatostatin receptor imaging in active cardiac sarcoidosis: Would less be enough? 38
31332660 2019
23
Risk stratification in cardiac sarcoidosis: The tricky business of predicting the future. 38
31310361 2019
24
Screening sarcoidosis patients for cardiac sarcoidosis: What the data really show. 38
31126731 2019
25
Imaging in Suspected Cardiac Sarcoidosis: A Diagnostic Challenge. 38
31345153 2019
26
Tender cutaneous nodules in a patient with cardiac sarcoidosis. 38
31313845 2019
27
Resolution of new left bundle branch block and ventricular tachycardia with immunosuppressive therapy in a patient with cardiac sarcoidosis. 38
31341784 2019
28
Treatment of cardiac sarcoidosis. 38
31343492 2019
29
Advanced sarcoidosis. 38
31343491 2019
30
Update on Cardiac Sarcoidosis. 38
31322914 2019
31
Advanced Imaging in Cardiac Sarcoidosis. 38
31171594 2019
32
Minimally invasive biventricular mechanical circulatory support with Impella pumps as a bridge to heart transplantation: a first-in-the-world case report. 38
30968544 2019
33
Consecutive episodes of heart and kidney failure in an "otherwise" healthy young man. 38
31221126 2019
34
Feasibility of somatostatin receptor-targeted imaging for detection of myocardial inflammation: A pilot study. 38
31197742 2019
35
Cardiac involvement in cutaneous sarcoidosis. 38
26376041 2019
36
Sudden death in cardiac sarcoidosis: an analysis of nationwide clinical and cause-of-death registries. 38
31230070 2019
37
Cardiac sarcoidosis - an expert review for the chest physician. 38
30099918 2019
38
Electrophysiologic testing for diagnostic evaluation and risk stratification in patients with suspected cardiac sarcoidosis with preserved left and right ventricular systolic function. 38
31257683 2019
39
Prevalence of 18F-fluorodeoxyglucose positron emission tomography abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy. 38
30409737 2019
40
[Ventricular storm in a young man with primary hypokinetic dilated cardiomyopathy: why thinking of sarcoidosis?] 38
31184326 2019
41
Advanced Cardiac Imaging and the Complexity of Diagnosing Cardiac Sarcoidosis. 38
31177819 2019
42
Diagnostic Accuracy of Advanced Imaging in Cardiac Sarcoidosis. 38
31177817 2019
43
Electrophysiology study for risk stratification in patients with cardiac sarcoidosis and abnormal cardiac imaging. 38
31321283 2019
44
A new era of imaging for diagnosis and management of cardiac sarcoidosis: Hybrid cardiac magnetic resonance imaging and positron emission tomography. 38
31175626 2019
45
Preparation is everything: The impact of a structured preparation protocol on cardiac 18F-FDG PET imaging for cardiac sarcoidosis. 38
31250323 2019
46
Use of 18F-FDG PET/CT texture analysis to diagnose cardiac sarcoidosis. 38
30327855 2019
47
Effective steroid therapy in an elderly patient with cardiac sarcoidosis and severe left ventricular dysfunction. 38
31073350 2019
48
Cutaneous phaeohyphomycosis caused by Microsphaeropsis arundinis in a Japanese patient with cardiac sarcoidosis. 38
30320462 2019
49
Can phase analysis of gated myocardial perfusion single-photon emission computed tomography predict adverse outcome in cardiac sarcoidosis? 38
31069632 2019
50
Myocardial Involvement in Patients With Histologically Diagnosed Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis of Gross Pathological Images From Autopsy or Cardiac Transplantation Cases. 38
31070111 2019

Variations for Cardiac Sarcoidosis

Expression for Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for Cardiac Sarcoidosis

Pathways related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 TNF PSMB9 PSMB8 IL12B IFNG HLA-DQB1
2
Show member pathways
13.33 TNF PSMB9 PSMB8 IL12B IFNG CXCL8
3
Show member pathways
12.9 TNF IL12B IFNG CXCL8
4
Show member pathways
12.69 TNF IL12B IFNG HLA-DQB1 CXCL8
5
Show member pathways
12.6 TNF IL12B IFNG CXCL8
6
Show member pathways
12.48 TNF IL12B IFNG HLA-DQB1
7
Show member pathways
12.44 TNF IL12B IFNG HLA-DQB1
8
Show member pathways
12.35 PSMB8 IFNG HLA-DQB1
9
Show member pathways
12.28 TNF PSMB9 PSMB8 IL12B IFNG HLA-DQB1
10
Show member pathways
12.19 PSMB9 PSMB8 HLA-DQB1
11
Show member pathways
12.17 TNF IFNG CXCL8
12
Show member pathways
12.15 TNF IFNG CXCL8
13
Show member pathways
12.11 TNF PSMB9 PSMB8
14
Show member pathways
12.04 TNF IFNG CXCL8
15
Show member pathways
12.03 TNF IL12B IFNG HLA-DQB1
16 11.99 TNF IL12B IFNG HLA-DQB1
17
Show member pathways
11.93 TNF IL12B IFNG
18 11.88 TNF IFNG CXCL8
19 11.86 TNF IL12B CXCL8
20
Show member pathways
11.86 TNF PSMB8 IL12B IFNG CXCL8
21 11.68 TNF IFNG CCR6
22 11.65 TNF IL12B CXCL8
23
Show member pathways
11.64 TNF IFNG CXCL8
24
Show member pathways
11.55 TNF IFNG CXCL8
25 11.54 TNF IL12B CXCL8
26 11.48 TNF IL12B CXCL8
27 11.47 TNF IL12B IFNG CXCL8
28 11.4 TNF IFNG CXCL8
29 11.39 TNF IL12B CXCL8
30 11.37 TNF IL12B IFNG
31 11.35 TNF IL12B IFNG
32 11.34 TNF IFNG
33 11.33 IFNG CXCL8
34 11.25 PSMB9 IFNG
35 11.23 TNF IFNG HLA-DQB1 CXCL8
36 11.15 TNF IL12B IFNG
37
Show member pathways
11.13 IL12B IFNG
38 11.06 TNF IL12B CXCL8
39 11.05 TNF IL12B IFNG
40 11.03 TNF CXCL8
41 10.96 TNF IL12B IFNG
42 10.93 TNF CXCL8

GO Terms for Cardiac Sarcoidosis

Cellular components related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteasome core complex GO:0005839 9.16 PSMB9 PSMB8
2 proteasome core complex, beta-subunit complex GO:0019774 8.96 PSMB9 PSMB8
3 spermatoproteasome complex GO:1990111 8.62 PSMB9 PSMB8

Biological processes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.77 TNF IL12B CXCL8
2 cellular response to lipopolysaccharide GO:0071222 9.69 TNF IL12B CXCL8
3 interleukin-12-mediated signaling pathway GO:0035722 9.62 IL12B IFNG
4 positive regulation of interferon-gamma production GO:0032729 9.61 TNF IL12B
5 extrinsic apoptotic signaling pathway GO:0097191 9.61 TNF IFNG
6 cell cycle arrest GO:0007050 9.61 IL12B IFNG CXCL8
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.59 TNF IFNG
8 antigen processing and presentation GO:0019882 9.58 PSMB8 HLA-DQB1
9 positive regulation of epithelial cell migration GO:0010634 9.58 IFNG CCR6
10 proteasomal protein catabolic process GO:0010498 9.57 PSMB9 PSMB8
11 negative regulation of smooth muscle cell proliferation GO:0048662 9.56 IL12B IFNG
12 proteasomal ubiquitin-independent protein catabolic process GO:0010499 9.55 PSMB9 PSMB8
13 positive regulation of protein complex assembly GO:0031334 9.54 TNF IFNG
14 positive regulation of interleukin-12 production GO:0032735 9.52 IL12B IFNG
15 humoral immune response GO:0006959 9.5 TNF IFNG CCR6
16 embryonic digestive tract development GO:0048566 9.49 TNF CXCL8
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.48 TNF IFNG
18 negative regulation of growth of symbiont in host GO:0044130 9.46 TNF IL12B
19 negative regulation of interleukin-17 production GO:0032700 9.4 IL12B IFNG
20 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.37 IL12B IFNG
21 immune response GO:0006955 9.35 TNF IFNG HLA-DQB1 CXCL8 CCR6
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 TNF IFNG
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 TNF IFNG
24 positive regulation of osteoclast differentiation GO:0045672 8.8 TNF IL12B IFNG

Molecular functions related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 threonine-type endopeptidase activity GO:0004298 8.96 PSMB9 PSMB8
2 cytokine activity GO:0005125 8.92 TNF IL12B IFNG CXCL8

Sources for Cardiac Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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