MCID: CRD003
MIFTS: 47

Cardiac Sarcoidosis

Categories: Immune diseases

Aliases & Classifications for Cardiac Sarcoidosis

MalaCards integrated aliases for Cardiac Sarcoidosis:

Name: Cardiac Sarcoidosis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13405
NCIt 51 C35589
SNOMED-CT 69 75403004
UMLS 74 C0392077

Summaries for Cardiac Sarcoidosis

Disease Ontology : 12 A sarcoidosis that is characterized by conduction abnormalities, arrhythmias, and congestive heart failure with noncaseating granulomas present on endomyocardial biopsy, and develops_from a type IV hypersensitivity reaction with noncaseating granulomas infiltrating the myocardial tissue, especially that of the left ventricle.

MalaCards based summary : Cardiac Sarcoidosis is related to sarcoidosis 1 and pericarditis. An important gene associated with Cardiac Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Prednisone and Fluorodeoxyglucose F18 have been mentioned in the context of this disorder. Affiliated tissues include heart, lymph node and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Cardiac Sarcoidosis

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 sarcoidosis 1 31.0 IFNG IL1B TNF
2 pericarditis 29.4 IFNG IL1B TNF
3 atrioventricular block 10.4
4 epstein-barr virus-associated gastric carcinoma 10.3 PSMB9 TNF
5 chikungunya 10.3 IL1B TNF
6 dengue shock syndrome 10.3 IL1B TNF
7 commensal bacterial infectious disease 10.3 IL1B TNF
8 palindromic rheumatism 10.3 IL1B TNF
9 keratoconjunctivitis sicca 10.3 IL1B TNF
10 complex regional pain syndrome 10.3 IL1B TNF
11 lymphangiosarcoma 10.3 SMUG1 TNF
12 extrinsic cardiomyopathy 10.3 IL1B TNF
13 intracranial hypertension 10.3 IL1B TNF
14 aphthous stomatitis 10.3 IL1B TNF
15 lymph node disease 10.3 IL1B TNF
16 idiopathic neutropenia 10.3 IL1B TNF
17 nasopharyngeal disease 10.2 PSMB9 SMUG1
18 patulous eustachian tube 10.2
19 myocarditis 10.2
20 nontuberculous mycobacterial lung disease 10.2 IL12B TNF
21 leprosy 3 10.2 IFNG TNF
22 kashin-beck disease 10.2 IL1B TNF
23 lepromatous leprosy 10.2 IFNG TNF
24 vulvar vestibulitis syndrome 10.2 IL1B TNF
25 spondyloarthropathy 10.2 IFNG TNF
26 paracoccidioidomycosis 10.2 IFNG TNF
27 echinococcosis 10.2 IFNG TNF
28 opportunistic mycosis 10.2 IFNG TNF
29 burns 10.2 IL1B TNF
30 testicular disease 10.2 IFNG TNF
31 mixed connective tissue disease 10.2 IFNG TNF
32 rere-related disorders 10.2
33 hepatitis e 10.2 IFNG TNF
34 glossitis 10.2 IL1B TNF
35 acute graft versus host disease 10.2 IFNG TNF
36 rasmussen encephalitis 10.2 IFNG TNF
37 laryngitis 10.2 IL1B TNF
38 cerebral artery occlusion 10.2 IL1B TNF
39 retinitis pigmentosa 60 10.2 IL1B TNF
40 irritant dermatitis 10.2 IL1B TNF
41 acute vascular insufficiency of intestine 10.2 IL1B TNF
42 congenital cytomegalovirus 10.2 IL1B TNF
43 actinic prurigo 10.2 IL1B TNF
44 osteosclerotic myeloma 10.2 IL1B TNF
45 arrhythmogenic right ventricular cardiomyopathy 10.2
46 poems syndrome 10.2 IL1B TNF
47 periapical periodontitis 10.2 IL1B TNF
48 autoimmune gastritis 10.2 IL1B TNF
49 stachybotrys chartarum 10.2 IL1B TNF
50 hemorrhagic fever 10.2 IFNG TNF

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to Cardiac Sarcoidosis

Symptoms & Phenotypes for Cardiac Sarcoidosis

GenomeRNAi Phenotypes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 CXCL8 IL1B PSMB8 PSMB9 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 CXCL8 IL1B PSMB8 PSMB9 TNF

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.17 IFNG IL12B IL1B PSMB8 PSMB9 SMUG1

Drugs & Therapeutics for Cardiac Sarcoidosis

Drugs for Cardiac Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 3 53-03-2 5865
2 Fluorodeoxyglucose F18 Phase 4,Phase 2,Not Applicable
3 Radiopharmaceuticals Phase 4,Phase 2,Not Applicable
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
5 Hormone Antagonists Phase 4,Phase 3,Not Applicable
6 Hormones Phase 4,Phase 3,Not Applicable
7 glucocorticoids Phase 4,Phase 3,Not Applicable
8 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Not Applicable
9 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
10
leucovorin Approved Phase 3 58-05-9 6006 143
11
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
13 Parenteral Nutrition Solutions Phase 2, Phase 3
14 Hematinics Phase 2, Phase 3
15 Pharmaceutical Solutions Phase 2, Phase 3
16 Ferrosoferric Oxide Phase 2, Phase 3
17 Dermatologic Agents Phase 3
18 Antirheumatic Agents Phase 3
19 Folic Acid Antagonists Phase 3
20 Immunologic Factors Phase 3
21 Nucleic Acid Synthesis Inhibitors Phase 3
22 Antimetabolites, Antineoplastic Phase 3
23 Vitamin B9 Phase 3
24 Folate Phase 3
25 Vitamin B Complex Phase 3
26 Antimetabolites Phase 3
27 Immunosuppressive Agents Phase 3
28
Somatostatin Approved, Investigational Not Applicable 38916-34-6, 51110-01-1 53481605
29
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
30
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
31
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
32
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
33
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
34 Protective Agents Not Applicable
35 Gastrointestinal Agents Not Applicable
36 Neuroprotective Agents Not Applicable
37 Antiemetics Not Applicable
38 Methylprednisolone Acetate Not Applicable
39 Autonomic Agents Not Applicable
40 Peripheral Nervous System Agents Not Applicable
41 Prednisolone acetate Not Applicable

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis Recruiting NCT03549598 Phase 4 68Ga-DOTATATE PET/CT;18FDG PET/CT scan;13NH3 PET/CT scan
2 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
4 Cardiac Sarcoidosis Randomized Trial Recruiting NCT03593759 Phase 3 Prednisone;Methotrexate
5 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Completed NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
6 18F-FSPG PET/MRI or PET/CT Imaging of Cardiac Sarcoidosis or Inflammation Recruiting NCT03103490 Phase 2 18F-FSPG
7 18F-FDG PET Imaging in Cardiac Sarcoidosis Approved for marketing NCT01764191
8 Cardiac Sarcoidosis: FDG PET vs. Ga-DOTANOC PET Completed NCT01729169
9 Implantable Cardiac Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis Completed NCT01013311
10 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Completed NCT02546388 Not Applicable Indium-111 Pentreotide
11 Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis Completed NCT01648933 Not Applicable
12 Cardiac Sarcoidosis and FDG-PET Completed NCT00958087
13 Somatostatin Receptor Imaging in Cardiac Sarcoidosis Recruiting NCT02812849 Cu-64 DOTATATE
14 PET/MR Imaging In Patients With Cardiac Sarcoidosis Recruiting NCT03705884 Not Applicable Prednisolone
15 CASPA: CArdiac Sarcoidosis in PApworth Recruiting NCT03599414
16 Cardiac Sarcoidosis Multi-Center Prospective Cohort Recruiting NCT01477359
17 Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis Recruiting NCT03561025 Not Applicable
18 PET MRI Study in Patients With Cardiac Sarcoidosis Recruiting NCT03356756
19 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC Recruiting NCT02989480
20 Mayo AVC Registry and Biobank Recruiting NCT03049254
21 PET Imaging in Patients With Suspected Cardiac Sarcoidosis Active, not recruiting NCT03746847 Gallium-68 DOTATATE
22 Routine Cardiac Screening in Sarcoidosis Patients Not yet recruiting NCT03902223 Not Applicable
23 Cell Free DNA in Cardiac Sarcoidosis Not yet recruiting NCT03858777 Not Applicable
24 Non-Invasive Characterization in Cardiac Sarcoidosis Terminated NCT02017522 Not Applicable

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

MalaCards organs/tissues related to Cardiac Sarcoidosis:

42
Heart, Lymph Node, Monocytes, Lung, Brain, Bone, Testes

Publications for Cardiac Sarcoidosis

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 732)
# Title Authors Year
1
Same day comparison of PET/CT and PET/MR in patients with cardiac sarcoidosis. ( 30603887 )
2019
2
Diagnostic performance of F-18 FDG PET for detection of cardiac sarcoidosis; A systematic review and meta-analysis. ( 30603894 )
2019
3
18F-FDG uptake of the right ventricle is an important predictor of histopathologic diagnosis by endomyocardial biopsy in patients with cardiac sarcoidosis. ( 30610523 )
2019
4
Prognostic Impact of FDG-PET/CT Images in Patients With Suspected Cardiac Sarcoidosis: Optimal Patient Preparation, Not Complex Unconventional Analytics, Is Key to Meaningful Data. ( 30621993 )
2019
5
Lymph Vessel Proliferation on Cardiac Biopsy May Help in the Diagnosis of Cardiac Sarcoidosis. ( 30636545 )
2019
6
Management of Arrhythmias Associated with Cardiac Sarcoidosis. ( 30693680 )
2019
7
Rejection in heart transplantation for cardiac sarcoidosis mimicking idiopathic giant cell myocarditis: long-term follow-up. ( 30720635 )
2019
8
Using FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis. ( 30737635 )
2019
9
Imaging cardiac sarcoidosis with FDG-PET: Take a look at the right side! ( 30771159 )
2019
10
Diagnostic performance of F18 FDG PET in cardiac sarcoidosis: Are we getting closer to the truth? ( 30771161 )
2019
11
FDG-PET in possible cardiac sarcoidosis: Right ventricular uptake and high total cardiac metabolic activity predict cardiovascular events. ( 30815833 )
2019
12
Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis. ( 30815835 )
2019
13
Cardiac Sympathectomy For Refractory Ventricular Arrhythmias in Cardiac Sarcoidosis. ( 30818090 )
2019
14
Management of refractory ventricular tachycardia due to cardiac sarcoidosis-A biologic approach. ( 30820406 )
2019
15
Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients with Cardiac Sarcoidosis. ( 30825644 )
2019
16
PET/CT Evaluation of Cardiac Sarcoidosis. ( 30826020 )
2019
17
Cardiac sarcoidosis mimicking left ventricular noncompaction: An approach to acquired apical hypertrabeculation. ( 30834555 )
2019
18
Repeatability and Optimization of FDG Positron Emission Tomography for Evaluation of Cardiac Sarcoidosis. ( 30846271 )
2019
19
Cardiac sarcoidosis mimicking myocardial infarction: a comprehensive evaluation using computed tomography and positron emission tomography. ( 30911950 )
2019
20
Long-Term Outcome in Probable Versus Absolute Cardiac Sarcoidosis. ( 30527771 )
2019
21
Complementary Value of Cardiac Magnetic Resonance Imaging and Positron Emission Tomography/Computed Tomography in the Assessment of Cardiac Sarcoidosis. ( 29335272 )
2018
22
A Contemporary Analysis of Heart Transplantation and Bridge-to-Transplant Mechanical Circulatory Support Outcomes in Cardiac Sarcoidosis. ( 29482029 )
2018
23
A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance. ( 29405655 )
2018
24
Clinical presentation, management and prognosis of patients with cardiac sarcoidosis. ( 29619923 )
2018
25
18-FDG-PET in a patient cohort suspected for cardiac sarcoidosis: Right ventricular uptake is associated with pathological uptake in mediastinal lymph nodes. ( 29721764 )
2018
26
Cardiac sarcoidosis: a challenging diagnosis. ( 29777371 )
2018
27
Management of sudden cardiac death in cardiac sarcoidosis using the wearable cardioverter defibrillator. ( 29566033 )
2018
28
Active cardiac sarcoidosis on standard chest computed tomography. ( 29860431 )
2018
29
Gallium-68 DOTANOC scan in a patient withA suspected cardiac sarcoidosis. ( 29327255 )
2018
30
Importance of Early Diagnosis of Cardiac Sarcoidosis in Patients with Complete Atrioventricular Block. ( 29794391 )
2018
31
Serial FDG-PET/CT Imaging in the Management of Cardiac Sarcoidosis. ( 29215412 )
2018
32
A case of longitudinal care of a patient with cardiac sarcoidosis. ( 29423905 )
2018
33
Clinical characteristics associated with pacing-induced cardiac dysfunction: a high incidence of undiagnosed cardiac sarcoidosis before permanent pacemaker implantation. ( 29931541 )
2018
34
Isolated Cardiac Sarcoidosis Presenting with Stroke. ( 29557112 )
2018
35
Diagnostic value of quantitative assessment of cardiac <sup>18</sup>F-fluoro-2-deoxyglucose uptake in suspected cardiac sarcoidosis. ( 29560563 )
2018
36
Recovery of High Degree Atrioventricular Block in a Patient with Cardiac Sarcoidosis by Corticosteroid Therapy. ( 29399570 )
2018
37
How common is isolated cardiac sarcoidosis? Extra-cardiac and cardiac findings on clinical examination and whole-body<sup>18</sup>F-fluorodeoxyglucose positron emission tomography. ( 29306462 )
2018
38
Spontaneous Reduction in Abnormal Myocardial Uptake of Fluorine-18 Fluorodeoxygluose in a Patient with Cardiac Sarcoidosis. ( 29681578 )
2018
39
Identification of left ventricular chamber-like aneurysm related to cardiac sarcoidosis. ( 29914898 )
2018
40
Isolated cardiac sarcoidosis - A rare disease entity? ( 29306463 )
2018
41
Diagnostic accuracy and prognostic value of simultaneous hybrid 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in cardiac sarcoidosis. ( 29319785 )
2018
42
Focal Myocardial Damage in Cardiac Sarcoidosis Characterized by Strain Analysis on Magnetic Resonance Tagged Imaging in Comparison with Fluorodeoxyglucose Positron Emission Tomography Accumulation and Magnetic Resonance Late Gadolinium Enhancement. ( 29613987 )
2018
43
Establishing an Evidence-Based Method to Diagnose Cardiac Sarcoidosis: The Complementary Use of Cardiac Magnetic Resonance Imaging and FDG-PET. ( 29335273 )
2018
44
11C-4DST PET/CT Imaging of Cardiac Sarcoidosis: Comparison With 18F-FDG and Cardiac MRI. ( 29538030 )
2018
45
Isolated cardiac sarcoidosis: the crucial role of multimodal imaging with positron emission tomography/magnetic resonance imaging in diagnosis and therapy surveillance. ( 29182753 )
2018
46
Robotically Guided Left Ventricular Biopsy to Diagnose Cardiac Sarcoidosis: A Multidisciplinary Innovation Leading to First-in-Human Case. ( 29519901 )
2018
47
Cardiac Sarcoidosis: A Review of Contemporary Challenges in Diagnosis and Treatment. ( 29406038 )
2018
48
Case Presentation Commentary on &amp;quot;A case of longitudinal care of a patient with cardiac sarcoidosis&amp;quot;. ( 29423904 )
2018
49
Prognostic role of serial quantitative evaluation of <sup>18</sup>F-fluorodeoxyglucose uptake by PET/CT in patients with cardiac sarcoidosis presenting with ventricular tachycardia. ( 29610956 )
2018
50
Bi-atrial fibrosis detected using three-dimensional late gadolinium enhancement magnetic resonance imaging in a patient with cardiac sarcoidosis. ( 29876123 )
2018

Variations for Cardiac Sarcoidosis

Expression for Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for Cardiac Sarcoidosis

Pathways related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CXCL8 IFNG IL12B IL1B PSMB8 PSMB9
2
Show member pathways
13.37 CXCL8 IFNG IL12B IL1B PSMB8 PSMB9
3
Show member pathways
13.19 CXCL8 IFNG IL12B IL1B PSMB8 PSMB9
4
Show member pathways
13.08 CXCL8 IFNG IL12B IL1B TNF
5
Show member pathways
12.78 CXCL8 IFNG IL12B IL1B TNF
6
Show member pathways
12.65 CXCL8 IFNG IL12B IL1B TNF
7
Show member pathways
12.52 IFNG IL12B IL1B TNF
8
Show member pathways
12.51 IFNG IL12B IL1B TNF
9 12.48 IFNG IL1B PSMB8 TNF
10
Show member pathways
12.48 CXCL8 IFNG IL12B IL1B TNF
11
Show member pathways
12.32 IL1B PSMB8 PSMB9
12
Show member pathways
12.32 IFNG IL1B TNF
13
Show member pathways
12.27 CXCL8 IFNG IL1B TNF
14
Show member pathways
12.24 IFNG IL1B TNF
15
Show member pathways
12.24 CXCL8 IFNG IL1B TNF
16
Show member pathways
12.2 IFNG IL12B IL1B TNF
17
Show member pathways
12.17 PSMB8 PSMB9 TNF
18 12.17 IFNG IL12B IL1B TNF
19
Show member pathways
12.14 CXCL8 IL1B TNF
20
Show member pathways
12.13 IL12B IL1B TNF
21
Show member pathways
12.13 IFNG IL1B TNF
22
Show member pathways
12.12 CXCL8 IFNG IL1B TNF
23 12.1 CXCL8 IL1B TNF
24 12.02 IFNG IL1B TNF
25
Show member pathways
12 CXCL8 IFNG IL12B IL1B
26
Show member pathways
11.99 IFNG IL12B IL1B TNF
27 11.98 IFNG IL1B TNF
28
Show member pathways
11.97 IFNG IL1B TNF
29 11.95 CXCL8 IFNG IL1B TNF
30
Show member pathways
11.92 IFNG IL12B IL1B
31 11.92 CXCL8 IL12B IL1B TNF
32 11.89 CXCL8 IFNG IL1B
33 11.86 CXCL8 IL1B TNF
34 11.84 CXCL8 IL1B TNF
35
Show member pathways
11.84 CXCL8 IFNG IL12B IL1B PSMB8 TNF
36 11.81 CXCL8 IFNG IL1B TNF
37 11.79 CXCL8 IFNG IL1B
38 11.74 IFNG IL1B TNF
39
Show member pathways
11.72 CXCL8 IFNG TNF
40 11.71 CXCL8 IL12B IL1B TNF
41 11.7 IFNG IL1B TNF
42 11.68 IFNG IL1B TNF
43 11.61 CXCL8 IL12B IL1B TNF
44
Show member pathways
11.6 CXCL8 IFNG IL1B TNF
45 11.52 CXCL8 IL12B IL1B TNF
46 11.46 IFNG IL1B TNF
47 11.45 CXCL8 IL12B IL1B TNF
48 11.42 CXCL8 IFNG IL1B TNF
49 11.39 IFNG IL12B IL1B TNF
50 11.38 CXCL8 IFNG

GO Terms for Cardiac Sarcoidosis

Cellular components related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 CXCL8 IFNG IL12B IL1B TNF
2 proteasome core complex GO:0005839 9.16 PSMB8 PSMB9
3 proteasome core complex, beta-subunit complex GO:0019774 8.96 PSMB8 PSMB9
4 spermatoproteasome complex GO:1990111 8.62 PSMB8 PSMB9

Biological processes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CXCL8 IFNG IL1B TNF
2 cytokine-mediated signaling pathway GO:0019221 9.84 CXCL8 IL12B IL1B TNF
3 positive regulation of protein phosphorylation GO:0001934 9.82 IFNG IL1B TNF
4 cell cycle arrest GO:0007050 9.77 CXCL8 IFNG IL12B
5 extrinsic apoptotic signaling pathway GO:0097191 9.69 IFNG TNF
6 regulation of insulin secretion GO:0050796 9.69 IFNG IL1B TNF
7 positive regulation of phagocytosis GO:0050766 9.68 IL1B TNF
8 protein kinase B signaling GO:0043491 9.68 IL1B TNF
9 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.68 IL1B TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.68 IL1B TNF
11 proteasomal protein catabolic process GO:0010498 9.67 PSMB8 PSMB9
12 negative regulation of smooth muscle cell proliferation GO:0048662 9.67 IFNG IL12B
13 positive regulation of interleukin-8 production GO:0032757 9.67 IL1B TNF
14 negative regulation of neurogenesis GO:0050768 9.66 IL1B TNF
15 positive regulation of interleukin-12 production GO:0032735 9.66 IFNG IL12B
16 positive regulation of protein complex assembly GO:0031334 9.65 IFNG TNF
17 proteasomal ubiquitin-independent protein catabolic process GO:0010499 9.65 PSMB8 PSMB9
18 regulation of signaling receptor activity GO:0010469 9.65 CXCL8 IFNG IL12B IL1B TNF
19 embryonic digestive tract development GO:0048566 9.64 CXCL8 TNF
20 negative regulation of lipid catabolic process GO:0050995 9.63 IL1B TNF
21 positive regulation of glial cell proliferation GO:0060252 9.63 IL1B TNF
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.63 IL12B IL1B TNF
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.62 IL1B TNF
24 cellular response to lipopolysaccharide GO:0071222 9.62 CXCL8 IL12B IL1B TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.61 IL12B TNF
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
27 positive regulation of interferon-gamma production GO:0032729 9.61 IL12B IL1B TNF
28 negative regulation of interleukin-17 production GO:0032700 9.59 IFNG IL12B
29 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.58 IL12B IL1B
30 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.58 IFNG IL12B
31 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IFNG IL1B TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IL1B TNF
33 regulation of establishment of endothelial barrier GO:1903140 9.56 IL1B TNF
34 positive regulation of neuroinflammatory response GO:0150078 9.55 IL1B TNF
35 positive regulation of fever generation GO:0031622 9.52 IL1B TNF
36 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
37 positive regulation of JUN kinase activity GO:0043507 9.39 TNF
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
39 positive regulation of neutrophil chemotaxis GO:0090023 9.35 CXCL8
40 positive regulation of osteoclast differentiation GO:0045672 9.33 IFNG IL12B TNF
41 chronic inflammatory response to antigenic stimulus GO:0002439 9.19 TNF
42 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.13 IFNG IL1B TNF
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IFNG IL12B IL1B TNF
2 threonine-type endopeptidase activity GO:0004298 8.96 PSMB8 PSMB9

Sources for Cardiac Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....