MCID: CRD003
MIFTS: 44

Cardiac Sarcoidosis

Categories: Immune diseases

Aliases & Classifications for Cardiac Sarcoidosis

MalaCards integrated aliases for Cardiac Sarcoidosis:

Name: Cardiac Sarcoidosis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13405
NCIt 49 C35589
SNOMED-CT 67 75403004
UMLS 71 C0392077

Summaries for Cardiac Sarcoidosis

Disease Ontology : 12 A sarcoidosis that is characterized by conduction abnormalities, arrhythmias, and congestive heart failure with noncaseating granulomas present on endomyocardial biopsy, and develops from a type IV hypersensitivity reaction with noncaseating granulomas infiltrating the myocardial tissue, especially that of the left ventricle.

MalaCards based summary : Cardiac Sarcoidosis is related to pulmonary sarcoidosis and skin sarcoidosis. An important gene associated with Cardiac Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Fluorodeoxyglucose F18 and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and kidney, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Cardiac Sarcoidosis

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 416)
# Related Disease Score Top Affiliating Genes
1 pulmonary sarcoidosis 30.7 TNF IFNG ACE
2 skin sarcoidosis 30.6 TNF ACE
3 uveitis 30.4 TNF IFNG CXCL8
4 myocarditis 30.1 TNF IL1B IFNG HLA-DQB1 ACE
5 neurosarcoidosis 30.0 TNF ACE
6 systolic heart failure 30.0 TNF LGALS3 ACE
7 endocarditis 29.8 TNF IFNG CXCL8
8 lyme disease 29.7 TNF IL1B HLA-DQB1
9 choroiditis 29.7 TNF IFNG ACE
10 sarcoidosis 1 29.7 TNF S100A9 IL1B IL15 IFNG HLA-DQB1
11 pulmonary tuberculosis 29.5 TNF IL12B IFNG HLA-DQB1
12 extrinsic allergic alveolitis 29.5 IL1B IL15 CXCL8
13 toxic shock syndrome 29.4 TNF IL1B IFNG CXCL8
14 coronary artery anomaly 29.4 TNF IL1B CXCL8 ACE
15 ulcerative colitis 29.4 TNF IL1B IFNG CXCL8
16 pericarditis 29.3 TNF IL1B IFNG CXCL8 ACE
17 dilated cardiomyopathy 29.3 TNF LGALS3 IL1B IFNG HLA-DQB1 CXCL8
18 pulmonary hypertension 29.2 TNF IL1B CXCL8 ACE
19 pulmonary edema 29.2 TNF IL1B CXCL8 ACE
20 myocardial infarction 28.6 TNF LGALS3 IL1B IFNG CXCL8 ACE
21 autoimmune disease 27.2 TNF PSMB9 IL5 IL1B IL15 IL12B
22 lung disease 26.1 TNF S100A9 S100A8 IL5 IL1B IL15
23 atrioventricular block 10.7
24 cardiac conduction defect 10.6
25 congestive heart failure 10.6
26 beryllium disease 10.5 TNF HLA-DQB1
27 idiopathic anterior uveitis 10.5 TNF CXCL8
28 streptococcal toxic-shock syndrome 10.4 TNF CXCL8
29 polyarticular juvenile idiopathic arthritis 10.4 TNF IFNG
30 autoimmune myocarditis 10.4 TNF IFNG
31 arrhythmogenic right ventricular cardiomyopathy 10.4
32 spotted fever rickettsiosis 10.4 TNF IFNG
33 atrial standstill 1 10.4
34 haemophilus influenzae 10.4 TNF CXCL8
35 toxicodendron dermatitis 10.4 TNF CXCL8
36 progressive familial heart block, type ia 10.4
37 systemic onset juvenile idiopathic arthritis 10.4 TNF IL1B
38 mycobacterium abscessus 10.4 TNF CXCL8
39 soft tissue sarcoma 10.4 TNF IFNG
40 histoplasmosis pericarditis 10.3 TNF ACE
41 nontuberculous mycobacterial lung disease 10.3 TNF IL12B
42 vulvar vestibulitis syndrome 10.3 TNF IL1B
43 palladium allergic contact dermatitis 10.3 TNF IL1B
44 kashin-beck disease 10.3 TNF IL1B
45 gastrointestinal tuberculosis 10.3 TNF IFNG
46 intestinal tuberculosis 10.3 TNF IFNG
47 subacute cutaneous lupus erythematosus 10.3 TNF ACE
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 TNF IL5
49 ventricular fibrillation, paroxysmal familial, 1 10.3
50 dermatitis, atopic, 8 10.3 IL1B CXCL8

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to Cardiac Sarcoidosis

Symptoms & Phenotypes for Cardiac Sarcoidosis

GenomeRNAi Phenotypes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 ACE CXCL8 HLA-DQB1 IL1B PSMB8 PSMB9
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 ACE CXCL8 HLA-DQB1 IL1B PSMB8 PSMB9

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 ACE HLA-DMA HLA-DQB1 IFNG IL12B IL15
2 growth/size/body region MP:0005378 10.02 ACE HLA-DMA HLA-DQB1 IFNG IL12B IL15
3 immune system MP:0005387 9.97 ACE HLA-DMA HLA-DQB1 IFNG IL12B IL15
4 mortality/aging MP:0010768 9.7 ACE HLA-DMA HLA-DQB1 IFNG IL12B IL15
5 neoplasm MP:0002006 9.28 ACE IFNG IL12B IL1B IL5 LGALS3

Drugs & Therapeutics for Cardiac Sarcoidosis

Drugs for Cardiac Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorodeoxyglucose F18 Phase 4
2 Radiopharmaceuticals Phase 4
3
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
4
leucovorin Approved Phase 3 58-05-9 6006 143
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
6 Hematinics Phase 2, Phase 3
7 Ferrosoferric Oxide Phase 2, Phase 3
8 Pharmaceutical Solutions Phase 2, Phase 3
9 Parenteral Nutrition Solutions Phase 2, Phase 3
10 Antirheumatic Agents Phase 3
11 Immunologic Factors Phase 3
12 Vitamin B Complex Phase 3
13 Folic Acid Antagonists Phase 3
14 Vitamin B9 Phase 3
15 Dermatologic Agents Phase 3
16 Folate Phase 3
17 Antimetabolites Phase 3
18 Immunosuppressive Agents Phase 3
19 Interleukin 1 Receptor Antagonist Protein Phase 2
20
Methylprednisolone hemisuccinate Approved 2921-57-5
21
Methylprednisolone Approved, Vet_approved 83-43-2 6741
22
Prednisolone Approved, Vet_approved 50-24-8 5755
23
Prednisolone phosphate Approved, Vet_approved 302-25-0
24 Prednisolone acetate Approved, Vet_approved 52-21-1
25
Somatostatin Approved, Investigational 51110-01-1, 38916-34-6 53481605
26
Prednisolone hemisuccinate Experimental 2920-86-7
27 Gastrointestinal Agents
28 Antiemetics
29 Methylprednisolone Acetate
30 Autonomic Agents
31 Neuroprotective Agents
32 Protective Agents

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis Recruiting NCT03549598 Phase 4 68Ga-DOTATATE PET/CT;18FDG PET/CT scan;13NH3 PET/CT scan
2 CArdiac Sarcoidosis Response TO steRoids (CASTOR) Trial Withdrawn NCT01210677 Phase 4 Prednisone
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
4 Cardiac Sarcoidosis Multi-Center Randomized Controlled Trial Recruiting NCT03593759 Phase 3 Prednisone;Methotrexate
5 18F-FSPG PET/MRI or PET/CT Imaging of Cardiac Sarcoidosis or Inflammation Recruiting NCT03103490 Phase 2 18F-FSPG
6 Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis Recruiting NCT04017936 Phase 2 Anakinra;Placebos
7 Somatostatin Receptor Imaging in Cardiac Sarcoidosis Unknown status NCT02812849 Cu-64 DOTATATE
8 Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications Unknown status NCT02062008
9 Sub-project: Use of Small Implantable ECG Recorder in Pregnant Women With Arrhythmia Unknown status NCT02249195
10 [18 F]-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET) in Cardiac Sarcoidosis Approved for marketing NCT01764191
11 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Completed NCT02546388 Indium-111 Pentreotide
12 Diagnosing Cardiac Sarcoidosis Using FDG PET: Optimization Completed NCT01729169
13 18F-fluorodeoxyglucose Positron Emission Tomography Imaging in Cardiac Sarcoidosis Reveals Characteristic Heterogeneity of Tracer Uptake and the Disease Activity in Myocardium Completed NCT00958087
14 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Myocardial Perfusion Imaging for Evaluation of Cardiac Sarcoidosis Completed NCT03048097 Early Phase 1 Fluorodeoxyglucose;Rubidium
15 Efficacy if Implantable Cardioverter Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis Completed NCT01013311
16 Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis Completed NCT01648933
17 A Randomized Screening Trial for Cardiac Sarcoidosis (CS) in Patients Seen During Routine Clinical Care Who Have Not Been Clinically Suspected to Have (CS), Comparing the Addition of Echocardiogram and Ambulatory ECG to Standard of Care. Recruiting NCT03902223
18 Molecular Imaging in Cardiovascular Disease Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR): Cardiac Sarcoidosis Recruiting NCT03705884 Prednisolone
19 Feasibility and Accuracy of Hybrid Magnetic Resonance and Positron Emission Tomography With 18F-Fluorodeoxyglucose in Diagnosing Cardiac Sarcoidosis Recruiting NCT03923049
20 Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis: A Pilot Study Combining Advanced MRI and 18F-FDG and 18F-GE180 PET of the Myocardium Recruiting NCT03561025
21 Cardiac Sarcoidosis Multi-Center Prospective Cohort Study Recruiting NCT01477359
22 Diagnostic and Prognostic Significance of Combined PET/MRI in Inflammatory Cardiomyopathies and Sarcoidosis Recruiting NCT03356756
23 Detection and Prognostic Significance of Myocardial Damage Visualized by Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis Recruiting NCT01745237
24 Cardiomyocyte Specific Cell Free DNA as a Marker of Cardiac Sarcoidosis Recruiting NCT03858777
25 Evaluation of 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging in Myocarditis Recruiting NCT03777839
26 CASPA (CArdiac Sarcoidosis in PApworth): Improving the Diagnosis of Cardiac Disease in Patients With Pulmonary Sarcoidosis Recruiting NCT03599414
27 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC - a Feasibility Study Recruiting NCT02989480
28 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Active, not recruiting NCT03746847 Gallium-68 DOTATATE
29 Non-Invasive Characterization in Cardiac Sarcoidosis Terminated NCT02017522

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

MalaCards organs/tissues related to Cardiac Sarcoidosis:

40
Heart, Lung, Kidney, Testes, Monocytes, Thyroid, Skin

Publications for Cardiac Sarcoidosis

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 1199)
# Title Authors PMID Year
1
Clinicopathological manifestations of myocarditis in a heart failure population. 61
31896440 2020
2
The Many Faces of Cardiac Sarcoidosis. 61
31769474 2020
3
Cardiac Sarcoidosis multi-center randomized controlled trial (CHASM CS- RCT). 61
31911261 2020
4
Regional Myocardial Remodeling Characteristics Correlates With Cardiac Events in Sarcoidosis. 61
31950573 2020
5
Sarcoidosis presenting as cardiac tamponade: a case report. 61
32000632 2020
6
Imaging cardiac sarcoidosis and infiltrative diseases: diagnosis and therapeutic response. 61
31992689 2020
7
Diagnostic and predictive value of speckle tracking echocardiography in cardiac sarcoidosis. 61
31959111 2020
8
A case of cardiac sarcoidosis with left ventricular thrombus formation after administration of prednisolone. 61
31720924 2020
9
Prognostic Value of 18F-FDG PET Using Texture Analysis in Cardiac Sarcoidosis. 61
31954654 2020
10
Effect of Corticosteroid Dose and Duration on 18-Fluorodeoxyglucose Positron Emission Tomography in Cardiac Sarcoidosis. 61
31954655 2020
11
Prognosis and risk stratification in cardiac sarcoidosis patients with preserved left ventricular ejection fraction. 61
31277963 2020
12
[Diagnostics and Treatment of Cardiac Sarcoidosis - Consensus Paper of the German Respiratory Society (DGP) and the German Cardiac Society (DGK)]. 61
31863422 2020
13
Impact of the inflammation on the outcomes of catheter ablation of drug-refractory ventricular tachycardia in cardiac sarcoidosis. 61
31916658 2020
14
The Utility of Whole Body 18F-FDG PET-CT in Diagnosing Isolated Cardiac Sarcoidosis: The Western Australian Cardiac Sarcoid Study. 61
31501049 2020
15
Subclinical involvement of the heart and its associated factors in patients with sarcoidosis with normal systolic function using 2D speckle tracking. 61
31944375 2020
16
Assessing the qualitative and quantitative impacts of simple two-class vs multiple tissue-class MR-based attenuation correction for cardiac PET/MR. 61
31898004 2020
17
Inflammatory cardiomyopathies: short- and long-term outcomes after heart transplantation-a protocol for a systematic review and meta-analysis. 61
31932994 2020
18
Right ventricular involvement is an important prognostic factor and risk stratification tool in suspected cardiac sarcoidosis: analysis by cardiac magnetic resonance imaging. 61
31872264 2019
19
A new era of imaging for diagnosis and management of cardiac sarcoidosis: Hybrid cardiac magnetic resonance imaging and positron emission tomography. 61
31175626 2019
20
18F-FMISO PET/CT detects hypoxic lesions of cardiac and extra-cardiac involvement in patients with sarcoidosis. 61
31820409 2019
21
Diagnosis of cardiac sarcoidosis: an era of paradigm shift. 61
31848928 2019
22
Cardiac sarcoidosis: the complementary role of 18F-FDG PET and MRI. 61
31809284 2019
23
Myocardial perfusion imaging in cardiac sarcoidosis: A "sine qua non" for prognosis assessment? 61
31792915 2019
24
Clinical Features and Histopathology of Cardiac Sarcoidosis with Refractory Heart Failure: An Autopsy Case. 61
31434823 2019
25
Diagnostic Specificity of Basal Inferoseptal Triangular Late Gadolinium Enhancement for Identification of Cardiac Sarcoidosis. 61
31422121 2019
26
The chameleon of cardiology: cardiac sarcoidosis before and after heart transplantation. 61
31802644 2019
27
Infliximab for Refractory Cardiac Sarcoidosis. 61
31500815 2019
28
Cardiac Sarcoidosis. 61
31768666 2019
29
Update in Cardiac Sarcoidosis. 61
31322914 2019
30
Imaging Cardiac Sarcoidosis With FLT-PET Compared With FDG/Perfusion-PET: A Prospective Pilot Study. 61
31422126 2019
31
TNF-alpha inhibition for the treatment of cardiac sarcoidosis. 61
31806154 2019
32
Outcome of catheter ablation of supraventricular tachyarrhythmias in cardiac sarcoidosis. 61
31482624 2019
33
Diagnosis of cardiac sarcoidosis despite negative findings on serial late gadolinium enhancement with cardiac magnetic resonance imaging/18F-fluorodeoxyglucose positron emission tomography examinations. 61
31773564 2019
34
Detailed visualization of the right and left ventricular, left atrial, and epicardial involvement of cardiac sarcoidosis with novel semiconductor PET/CT. 61
31713658 2019
35
Localized basal left ventricular dyssynchrony induced by manifest accessory pathway: Successful differentiation from cardiac involvement of sarcoidosis with administration of flecainide acetate. 61
31522061 2019
36
Cardiac sarcoidosis: worse pulmonary function due to left ventricular ejection fraction?: A case-control study. 61
31764823 2019
37
Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis. 61
31631075 2019
38
Sarcoidosis presenting as facial and scalp ulceration with secondary bacterial infection of the skin. 61
31748362 2019
39
Sarcoidosis-Associated Pulmonary Hypertension: An Updated Review and Discussion of the Clinical Conundrum. 61
31889552 2019
40
JCS 2016 Guideline on Diagnosis and Treatment of Cardiac Sarcoidosis - Digest Version. 61
31597819 2019
41
Role of PET/CT in multimodality imaging in differentiating cardiac sarcoidosis from arrhythmogenic right ventricular dysplasia. 61
30051347 2019
42
The rate of myocardial perfusion recovery after steroid therapy and its implication for cardiac events in cardiac sarcoidosis and primarily preserved left ventricular ejection fraction. 61
31605274 2019
43
[Update of diagnosis and management of cardiac sarcoidosis]. 61
31594112 2019
44
Risk stratification in cardiac sarcoidosis: The tricky business of predicting the future. 61
31310361 2019
45
Regional abnormalities on cardiac magnetic resonance imaging and arrhythmic events in patients with cardiac sarcoidosis. 61
31328324 2019
46
Cardiac magnetic resonance imaging to predict arrhythmic events in cardiac sarcoidosis: Unmasking the great pretender? 61
31332847 2019
47
Recurrent cardiac sarcoidosis after heart transplantation. 61
31073636 2019
48
Sudden death in cardiac sarcoidosis: an analysis of nationwide clinical and cause-of-death registries. 61
31230070 2019
49
Electrophysiologic testing for diagnostic evaluation and risk stratification in patients with suspected cardiac sarcoidosis with preserved left and right ventricular systolic function. 61
31257683 2019
50
Pathological Overlap of Arrhythmogenic Right Ventricular Cardiomyopathy and Cardiac Sarcoidosis. 61
31542937 2019

Variations for Cardiac Sarcoidosis

Expression for Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for Cardiac Sarcoidosis

Pathways related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 TNF S100A9 S100A8 PSMB9 PSMB8 LGALS3
2
Show member pathways
13.53 TNF PSMB9 PSMB8 IL5 IL1B IL15
3
Show member pathways
13.25 TNF IL5 IL1B IL15 IL12B CXCL8
4
Show member pathways
13.24 TNF PSMB9 PSMB8 IL5 IL1B IL15
5
Show member pathways
13.1 TNF IL1B IL12B IFNG CXCL8 ACE
6
Show member pathways
12.83 TNF IL1B IL12B IFNG HLA-DQB1 HLA-DMA
7 12.82 IL5 IL15 IL12B IFNG CXCL8
8 12.81 TNF IL1B IL12B IFNG HLA-DQB1 HLA-DMA
9
Show member pathways
12.75 TNF IL1B IL12B IFNG CXCL8
10
Show member pathways
12.65 TNF IL5 IL1B IL15 IL12B IFNG
11
Show member pathways
12.63 TNF IL12B IFNG HLA-DQB1 HLA-DMA
12 12.58 TNF PSMB8 LGALS3 IL1B IFNG
13
Show member pathways
12.56 TNF IL5 IL1B IFNG
14
Show member pathways
12.56 TNF IL5 IL1B IL12B IFNG HLA-DQB1
15
Show member pathways
12.55 TNF IL1B IL12B IFNG
16
Show member pathways
12.35 IL5 IL15 IL12B IFNG
17 12.33 TNF IL15 HLA-DQB1 HLA-DMA
18
Show member pathways
12.3 TNF IL1B IFNG CXCL8
19
Show member pathways
12.26 TNF IL1B IL12B IFNG HLA-DQB1 HLA-DMA
20
Show member pathways
12.25 TNF S100A9 S100A8 IL5 IL1B IFNG
21 12.23 TNF IL1B IL12B IFNG HLA-DQB1 HLA-DMA
22
Show member pathways
12.19 TNF IL1B IFNG CXCL8
23
Show member pathways
12.13 TNF PSMB8 IL5 IL1B IL15 IL12B
24
Show member pathways
12.08 TNF IL1B IL12B IFNG
25 12.04 TNF LGALS3 IL1B IFNG CXCL8
26 12.02 TNF IL5 IL15 IFNG
27 12.01 TNF IL1B IL12B CXCL8
28 11.98 TNF IL1B CXCL8
29 11.95 TNF IL1B IL12B IFNG CXCL8
30
Show member pathways
11.94 IL1B IL12B IFNG
31 11.94 TNF IL1B IL15
32 11.93 TNF IL5 IL1B HLA-DQB1 HLA-DMA
33 11.91 IL1B IFNG CXCL8
34 11.89 TNF IL1B CXCL8
35 11.88 TNF IL1B CXCL8
36 11.83 TNF IL5 IL1B IL15 IFNG
37 11.81 TNF IL1B IL12B CXCL8
38
Show member pathways
11.81 TNF IL5 IFNG CXCL8
39 11.79 IL5 IFNG CXCL8
40 11.78 IL1B IFNG CXCL8
41 11.77 TNF IL1B IL15 IFNG
42 11.74 TNF IL1B IFNG
43
Show member pathways
11.72 TNF IL1B IFNG CXCL8
44 11.67 TNF IL1B IL12B CXCL8
45 11.67 TNF IL1B IL15 IFNG HLA-DQB1 HLA-DMA
46 11.65 TNF IL5 IL1B IL12B CXCL8
47 11.61 TNF IL1B IFNG CXCL8
48 11.59 TNF IL1B IL12B CXCL8
49 11.57 TNF IL1B IL12B IFNG
50 11.57 TNF IL1B IL12B IFNG

GO Terms for Cardiac Sarcoidosis

Cellular components related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.72 TNF LGALS3 IL15 IL12B HLA-DMA
2 extracellular region GO:0005576 9.7 TNF S100A9 S100A8 LGALS3 IL5 IL1B
3 extracellular space GO:0005615 9.36 TNF S100A9 S100A8 LGALS3 IL5 IL1B
4 proteasome core complex, beta-subunit complex GO:0019774 9.26 PSMB9 PSMB8
5 spermatoproteasome complex GO:1990111 9.16 PSMB9 PSMB8

Biological processes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.98 S100A9 S100A8 PSMB9 PSMB8 LGALS3 HLA-DQB1
2 cellular response to lipopolysaccharide GO:0071222 9.93 TNF IL1B IL12B CXCL8
3 cytokine-mediated signaling pathway GO:0019221 9.93 TNF IL5 IL1B IL12B CXCL8
4 MAPK cascade GO:0000165 9.91 TNF PSMB9 PSMB8 IL5 IL1B
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 TNF S100A9 S100A8 IL1B
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.89 TNF PSMB9 PSMB8
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 TNF IL5 IL1B
8 interleukin-1-mediated signaling pathway GO:0070498 9.88 PSMB9 PSMB8 IL1B
9 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.86 TNF S100A9 S100A8
10 regulation of inflammatory response GO:0050727 9.86 TNF S100A9 S100A8
11 regulation of insulin secretion GO:0050796 9.84 TNF IL1B IFNG
12 positive regulation of T cell proliferation GO:0042102 9.83 IL1B IL15 IL12B
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF IL1B IL12B
14 positive regulation of protein localization to plasma membrane GO:1903078 9.82 TNF LGALS3 IFNG
15 inflammatory response GO:0006954 9.8 TNF S100A9 S100A8 IL5 IL1B IL15
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 TNF IL1B IFNG
17 positive regulation of interferon-gamma production GO:0032729 9.79 TNF IL1B IL12B
18 antigen processing and presentation GO:0019882 9.78 PSMB8 HLA-DQB1 HLA-DMA
19 negative regulation of smooth muscle cell proliferation GO:0048662 9.76 IL15 IL12B IFNG
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 TNF IL15 IL12B IFNG
21 positive regulation of amyloid-beta formation GO:1902004 9.72 TNF IFNG
22 negative regulation of lipid catabolic process GO:0050995 9.72 TNF IL1B
23 neutrophil chemotaxis GO:0030593 9.72 S100A9 S100A8 LGALS3 IL1B CXCL8
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 TNF IL1B
25 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 TNF IL1B
26 positive regulation of interleukin-17 production GO:0032740 9.71 IL15 IL12B
27 negative regulation of interleukin-17 production GO:0032700 9.71 IL12B IFNG
28 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.7 HLA-DQB1 HLA-DMA
29 positive regulation of neuroinflammatory response GO:0150078 9.7 TNF IL1B
30 positive regulation of podosome assembly GO:0071803 9.7 TNF IL5
31 positive regulation of osteoclast differentiation GO:0045672 9.7 TNF IL12B IFNG
32 neutrophil activation GO:0042119 9.69 IL15 CXCL8
33 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.69 IL1B IL12B
34 negative regulation of amyloid-beta clearance GO:1900222 9.68 TNF IFNG
35 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.68 IL12B IFNG
36 leukocyte migration involved in inflammatory response GO:0002523 9.68 S100A9 S100A8
37 regulation of defense response to virus by host GO:0050691 9.67 IL1B IL15
38 positive regulation of natural killer cell proliferation GO:0032819 9.67 IL15 IL12B
39 astrocyte activation GO:0048143 9.67 TNF IL1B IFNG
40 positive regulation of phagocytosis GO:0050766 9.67 TNF IL1B IL15 IFNG
41 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
42 positive regulation of tissue remodeling GO:0034105 9.65 IL15 IL12B
43 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 TNF IL1B IFNG
44 positive regulation of mononuclear cell migration GO:0071677 9.64 TNF LGALS3
45 positive regulation of fever generation GO:0031622 9.64 TNF IL1B
46 sequestering of zinc ion GO:0032119 9.63 S100A9 S100A8
47 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
48 chemokine production GO:0032602 9.59 S100A9 S100A8
49 negative regulation of gap junction assembly GO:1903597 9.58 IL1B ACE
50 positive regulation of chemokine biosynthetic process GO:0045080 9.58 TNF IL1B IFNG

Molecular functions related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 TNF S100A9 S100A8 PSMB9 PSMB8 LGALS3
2 endopeptidase activity GO:0004175 9.43 PSMB9 PSMB8 ACE
3 RAGE receptor binding GO:0050786 9.32 S100A9 S100A8
4 cytokine activity GO:0005125 9.17 TNF IL5 IL1B IL15 IL12B IFNG
5 arachidonic acid binding GO:0050544 9.16 S100A9 S100A8
6 Toll-like receptor 4 binding GO:0035662 8.96 S100A9 S100A8

Sources for Cardiac Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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