MCID: CRD003
MIFTS: 41

Cardiac Sarcoidosis

Categories: Immune diseases

Aliases & Classifications for Cardiac Sarcoidosis

MalaCards integrated aliases for Cardiac Sarcoidosis:

Name: Cardiac Sarcoidosis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13405
NCIt 50 C35589
SNOMED-CT 68 75403004
UMLS 73 C0392077

Summaries for Cardiac Sarcoidosis

MalaCards based summary : Cardiac Sarcoidosis is related to epstein-barr virus-associated gastric carcinoma and central nervous system vasculitis. An important gene associated with Cardiac Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Regulation of IFNA signaling and Allograft rejection. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include heart, lymph node and monocytes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Cardiac Sarcoidosis

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 epstein-barr virus-associated gastric carcinoma 10.5 PSMB9 TNF
2 central nervous system vasculitis 10.4 SMUG1 TNF
3 tuberculous peritonitis 10.4 SMUG1 TNF
4 nakajo syndrome 10.4 PSMB8 TAP2
5 lymphangiosarcoma 10.4 SMUG1 TNF
6 hypersensitivity reaction type iv disease 10.3 SMUG1 TNF
7 cogan syndrome 10.3 SMUG1 TNF
8 immunodeficiency by defective expression of hla class 1 10.3 TAP1 TAP2
9 sialadenitis 10.2 TNC TNF
10 idiopathic bronchiectasis 10.2 TAP1 TAP2
11 atrioventricular block 10.2
12 bare lymphocyte syndrome, type i 10.2 TAP1 TAP2
13 myocarditis 10.1
14 aneurysm 10.1
15 angioimmunoblastic lymphadenopathy with dysproteinemia 10.0 IL5 TNF
16 scleritis 10.0 IL5 TNF
17 arrhythmogenic right ventricular cardiomyopathy 10.0
18 cellulitis 10.0 IL5 TNF
19 pustulosis palmaris et plantaris 10.0 IL5 TNF
20 churg-strauss syndrome 10.0 IL5 TNF
21 paracoccidioidomycosis 9.9 IL5 TNF
22 echinococcosis 9.9 IL5 TNF
23 nose disease 9.9 IL5 TNF
24 atrial standstill 1 9.9
25 dilated cardiomyopathy 9.9
26 parasitic helminthiasis infectious disease 9.9 IL5 TNF
27 upper respiratory tract disease 9.9 IL5 TNF
28 leukocyte disease 9.9 IL5 TNF
29 alveolar echinococcosis 9.9 TAP1 TAP2 TNF
30 cardiac conduction defect 9.9
31 giant cell myocarditis 9.9
32 spondylitis 9.9 TAP1 TAP2 TNF
33 filariasis 9.9 IL5 TNF
34 keratoconjunctivitis 9.8 IL5 TNF
35 allergic contact dermatitis 9.8 IL5 TNF
36 aging 9.8
37 hypertrophic cardiomyopathy 9.8
38 mediastinitis 9.8
39 gastroenteritis 9.8 IL5 TNF
40 cutaneous leishmaniasis 9.8 IL5 TNF
41 bronchial disease 9.7 IL5 TNF
42 progressive familial heart block, type ia 9.7
43 atrial fibrillation 9.7
44 syncope 9.7
45 contact dermatitis 9.7 IL5 TNF
46 hypersensitivity reaction disease 9.6 IL5 TNF
47 autoinflammation, lipodystrophy, and dermatosis syndrome 9.6 IL5 PSMB8 TNF
48 arteries, anomalies of 9.6
49 scleroderma, familial progressive 9.6
50 wolff-parkinson-white syndrome 9.6

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to Cardiac Sarcoidosis

Symptoms & Phenotypes for Cardiac Sarcoidosis

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 PSMB9 TAP1 TAP2 TNF IL5 PSMB8
2 immune system MP:0005387 9.43 PSMB8 PSMB9 TAP1 TAP2 TNF IL5
3 neoplasm MP:0002006 9.1 PSMB9 SMUG1 TAP1 TNF IL5 PSMB8

Drugs & Therapeutics for Cardiac Sarcoidosis

Drugs for Cardiac Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists Phase 4,Not Applicable
2 Hormones Phase 4,Not Applicable
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
4 Ferrosoferric Oxide Phase 2, Phase 3
5 Hematinics Phase 2, Phase 3
6 Parenteral Nutrition Solutions Phase 2, Phase 3
7 Pharmaceutical Solutions Phase 2, Phase 3
8 Fluorodeoxyglucose F18 Phase 2
9 Radiopharmaceuticals Phase 2
10
Somatostatin Approved, Investigational ,Not Applicable 38916-34-6, 51110-01-1 53481605

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis Not yet recruiting NCT03549598 Phase 4 68Ga-DOTATATE PET/CT;18FDG PET/CT scan;13NH3 PET/CT scan
2 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
4 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Completed NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
5 PET/MRI Imaging of Cardiac Sarcoidosis Recruiting NCT03103490 Phase 2 F18 FSPG
6 Cardiac Sarcoidosis: FDG PET vs. Ga-DOTANOC PET Completed NCT01729169
7 Implantable Cardiac Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis Completed NCT01013311
8 Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis Completed NCT01648933 Not Applicable
9 Cardiac Sarcoidosis and FDG-PET Completed NCT00958087
10 Somatostatin Receptor Imaging in Cardiac Sarcoidosis Recruiting NCT02812849 Cu-64 DOTATATE
11 Cardiac Sarcoidosis Multi-Center Prospective Cohort Recruiting NCT01477359
12 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Recruiting NCT02546388 Not Applicable Indium-111 Pentreotide
13 PET MRI Study in Patients With Cardiac Sarcoidosis Recruiting NCT03356756
14 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC Recruiting NCT02989480
15 Non-Invasive Characterization in Cardiac Sarcoidosis Active, not recruiting NCT02017522 Not Applicable
16 Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis Not yet recruiting NCT03561025 Not Applicable
17 18F-FDG PET Imaging in Cardiac Sarcoidosis No longer available NCT01764191

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

MalaCards organs/tissues related to Cardiac Sarcoidosis:

41
Heart, Lymph Node, Monocytes, T Cells, Myeloid, Testes, Brain

Publications for Cardiac Sarcoidosis

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 536)
# Title Authors Year
1
Complementary Value of Cardiac Magnetic Resonance Imaging and Positron Emission Tomography/Computed Tomography in the Assessment of Cardiac Sarcoidosis. ( 29335272 )
2018
2
A Contemporary Analysis of Heart Transplantation and Bridge-to-Transplant Mechanical Circulatory Support Outcomes in Cardiac Sarcoidosis. ( 29482029 )
2018
3
A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance. ( 29405655 )
2018
4
Clinical presentation, management and prognosis of patients with cardiac sarcoidosis. ( 29619923 )
2018
5
18-FDG-PET in a patient cohort suspected for cardiac sarcoidosis: Right ventricular uptake is associated with pathological uptake in mediastinal lymph nodes. ( 29721764 )
2018
6
Cardiac sarcoidosis: a challenging diagnosis. ( 29777371 )
2018
7
Management of sudden cardiac death in cardiac sarcoidosis using the wearable cardioverter defibrillator. ( 29566033 )
2018
8
Active cardiac sarcoidosis on standard chest computed tomography. ( 29860431 )
2018
9
Gallium-68 DOTANOC scan in a patient withA suspected cardiac sarcoidosis. ( 29327255 )
2018
10
Importance of Early Diagnosis of Cardiac Sarcoidosis in Patients with Complete Atrioventricular Block. ( 29794391 )
2018
11
Serial FDG-PET/CT Imaging in the Management of Cardiac Sarcoidosis. ( 29215412 )
2018
12
A case of longitudinal care of a patient with cardiac sarcoidosis. ( 29423905 )
2018
13
Clinical characteristics associated with pacing-induced cardiac dysfunction: a high incidence of undiagnosed cardiac sarcoidosis before permanent pacemaker implantation. ( 29931541 )
2018
14
Isolated Cardiac Sarcoidosis Presenting with Stroke. ( 29557112 )
2018
15
Diagnostic value of quantitative assessment of cardiac <sup>18</sup>F-fluoro-2-deoxyglucose uptake in suspected cardiac sarcoidosis. ( 29560563 )
2018
16
Recovery of High Degree Atrioventricular Block in a Patient with Cardiac Sarcoidosis by Corticosteroid Therapy. ( 29399570 )
2018
17
How common is isolated cardiac sarcoidosis? Extra-cardiac and cardiac findings on clinical examination and whole-body<sup>18</sup>F-fluorodeoxyglucose positron emission tomography. ( 29306462 )
2018
18
Spontaneous Reduction in Abnormal Myocardial Uptake of Fluorine-18 Fluorodeoxygluose in a Patient with Cardiac Sarcoidosis. ( 29681578 )
2018
19
Identification of left ventricular chamber-like aneurysm related to cardiac sarcoidosis. ( 29914898 )
2018
20
Isolated cardiac sarcoidosis - A rare disease entity? ( 29306463 )
2018
21
Diagnostic accuracy and prognostic value of simultaneous hybrid 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in cardiac sarcoidosis. ( 29319785 )
2018
22
Focal Myocardial Damage in Cardiac Sarcoidosis Characterized by Strain Analysis on Magnetic Resonance Tagged Imaging in Comparison with Fluorodeoxyglucose Positron Emission Tomography Accumulation and Magnetic Resonance Late Gadolinium Enhancement. ( 29613987 )
2018
23
Establishing an Evidence-Based Method to Diagnose Cardiac Sarcoidosis: The Complementary Use of Cardiac Magnetic Resonance Imaging and FDG-PET. ( 29335273 )
2018
24
11C-4DST PET/CT Imaging of Cardiac Sarcoidosis: Comparison With 18F-FDG and Cardiac MRI. ( 29538030 )
2018
25
Isolated cardiac sarcoidosis: the crucial role of multimodal imaging with positron emission tomography/magnetic resonance imaging in diagnosis and therapy surveillance. ( 29182753 )
2018
26
Robotically Guided Left Ventricular Biopsy to Diagnose Cardiac Sarcoidosis: A Multidisciplinary Innovation Leading to First-in-Human Case. ( 29519901 )
2018
27
Cardiac Sarcoidosis: A Review of Contemporary Challenges in Diagnosis and Treatment. ( 29406038 )
2018
28
Prognostic role of serial quantitative evaluation of <sup>18</sup>F-fluorodeoxyglucose uptake by PET/CT in patients with cardiac sarcoidosis presenting with ventricular tachycardia. ( 29610956 )
2018
29
Bi-atrial fibrosis detected using three-dimensional late gadolinium enhancement magnetic resonance imaging in a patient with cardiac sarcoidosis. ( 29876123 )
2018
30
Utility of left ventricular longitudinal strain in the diagnosis and treatment monitoring of cardiac sarcoidosis. ( 29511148 )
2018
31
Cardiac Sarcoidosis Concomitant with Large-vessel Aortitis Detected by<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography. ( 29321427 )
2018
32
Cardiac sarcoidosis: Diagnosis, therapeutic management and prognostic factors. ( 28566197 )
2017
33
Emergence of Integrated Cardiac MagneticA Resonance/Positron Emission Tomography Imaging as the Preferred Imaging Modality in Cardiac Sarcoidosis. ( 28624409 )
2017
34
The Challenges of Diagnosing Cardiac Sarcoidosis. ( 29216980 )
2017
35
Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia in a patient presenting with monomorphic ventricular tachycardia. ( 28948146 )
2017
36
Heterogeneity of myocardial 2-[18F]fluoro-2-deoxy-D-glucose uptake is a typical feature in cardiac sarcoidosis: a study of 231 patients. ( 28950301 )
2017
37
The role of serial FDG PET for assessing therapeutic response in patients with cardiac sarcoidosis. ( 27813028 )
2017
38
Serial FDG-PET scans help to identify steroid resistance in cardiac sarcoidosis. ( 27886616 )
2017
39
Electron microscopy gain a glimpse into the pathogenesis of cardiac sarcoidosis. ( 28633486 )
2017
40
Cardiac sarcoidosis after glucocorticoid therapy evaluated by (18)F-fluorodeoxyglucose PET/MRI. ( 28913789 )
2017
41
Serial electrocardiographic changes in isolated cardiac sarcoidosis. ( 28826341 )
2017
42
Semi-quantitative metabolic values on FDG PET/CT including extracardiac sites of disease as a predictor of treatment course in patients with cardiac sarcoidosis. ( 28822108 )
2017
43
Spontaneous regression of cardiac sarcoidosis resulting in total occlusion of coronary artery and ventricular aneurysm. ( 28063417 )
2017
44
Suppression of Myocardial 18F-FDG Uptake Through Prolonged High-Fat, High-Protein, and Very-Low-Carbohydrate Diet Before FDG-PET/CT for Evaluation of Patients With Suspected Cardiac Sarcoidosis. ( 27922863 )
2017
45
Trends in Hospitalizations for Cardiac Sarcoidosis in the United States, 2005-2011. ( 28904267 )
2017
46
Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis. ( 28624396 )
2017
47
Urinary 8-Hydroxy-2'-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis. ( 29208596 )
2017
48
Initial Experience With Simultaneous 18F-FDG PET/MRI in the Evaluation of Cardiac Sarcoidosis and Myocarditis. ( 28418949 )
2017
49
Cardiac sarcoidosis: challenges in clinical practice. ( 28661904 )
2017
50
Impact of early initiation of corticosteroid therapy on cardiac function and rhythm in patients with cardiac sarcoidosis. ( 27836297 )
2017

Variations for Cardiac Sarcoidosis

Expression for Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for Cardiac Sarcoidosis

GO Terms for Cardiac Sarcoidosis

Cellular components related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 9.37 TAP1 TAP2
2 proteasome complex GO:0000502 9.32 PSMB8 PSMB9
3 proteasome core complex GO:0005839 9.26 PSMB8 PSMB9
4 proteasome core complex, beta-subunit complex GO:0019774 9.16 PSMB8 PSMB9
5 spermatoproteasome complex GO:1990111 8.96 PSMB8 PSMB9
6 TAP complex GO:0042825 8.62 TAP1 TAP2

Biological processes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.81 PSMB8 PSMB9 TAP1 TAP2
2 immune system process GO:0002376 9.78 PSMB8 PSMB9 TAP1 TAP2
3 post-translational protein modification GO:0043687 9.74 PSMB8 PSMB9 TNC
4 viral process GO:0016032 9.71 PSMB8 PSMB9 TAP1 TAP2
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.63 PSMB8 PSMB9 TNF
6 NIK/NF-kappaB signaling GO:0038061 9.58 PSMB8 PSMB9
7 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.58 PSMB8 PSMB9
8 proteolysis involved in cellular protein catabolic process GO:0051603 9.56 PSMB8 PSMB9
9 regulation of cellular amino acid metabolic process GO:0006521 9.55 PSMB8 PSMB9
10 proteasomal protein catabolic process GO:0010498 9.54 PSMB8 PSMB9
11 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.52 TAP1 TAP2
12 proteasomal ubiquitin-independent protein catabolic process GO:0010499 9.49 PSMB8 PSMB9
13 MAPK cascade GO:0000165 9.46 IL5 PSMB8 PSMB9 TNF
14 positive regulation of podosome assembly GO:0071803 9.43 IL5 TNF
15 peptide transport GO:0015833 9.37 TAP1 TAP2
16 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.32 TAP1 TAP2
17 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.26 TAP1 TAP2
18 cytosol to ER transport GO:0046967 8.96 TAP1 TAP2
19 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 8.92 PSMB8 PSMB9 TAP1 TAP2

Molecular functions related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.43 TAP1 TAP2
2 threonine-type endopeptidase activity GO:0004298 9.4 PSMB8 PSMB9
3 MHC protein binding GO:0042287 9.37 TAP1 TAP2
4 peptide-transporting ATPase activity GO:0015440 9.32 TAP1 TAP2
5 TAP1 binding GO:0046978 9.26 TAP1 TAP2
6 peptide antigen-transporting ATPase activity GO:0015433 9.16 TAP1 TAP2
7 peptide transmembrane transporter activity GO:1904680 8.96 TAP1 TAP2
8 MHC class Ib protein binding GO:0023029 8.62 TAP1 TAP2

Sources for Cardiac Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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