MCID: CRD003
MIFTS: 44

Cardiac Sarcoidosis

Categories: Immune diseases

Aliases & Classifications for Cardiac Sarcoidosis

MalaCards integrated aliases for Cardiac Sarcoidosis:

Name: Cardiac Sarcoidosis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13405
NCIt 49 C35589
SNOMED-CT 67 75403004
UMLS 71 C0392077

Summaries for Cardiac Sarcoidosis

Disease Ontology : 12 A sarcoidosis that is characterized by conduction abnormalities, arrhythmias, and congestive heart failure with noncaseating granulomas present on endomyocardial biopsy, and develops from a type IV hypersensitivity reaction with noncaseating granulomas infiltrating the myocardial tissue, especially that of the left ventricle.

MalaCards based summary : Cardiac Sarcoidosis is related to sarcoidosis 1 and pulmonary sarcoidosis. An important gene associated with Cardiac Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Fluorodeoxyglucose F18 and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Related Diseases for Cardiac Sarcoidosis

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 476)
# Related Disease Score Top Affiliating Genes
1 sarcoidosis 1 30.9 TNF IL1B IL15 IFNG HLA-DQB1 ACE
2 pulmonary sarcoidosis 30.8 TNF IFNG ACE
3 skin sarcoidosis 30.5 TNF ACE
4 uveitis 30.1 TNF IL1B IFNG CXCL8
5 uveoparotid fever 30.0 TNF ACE
6 systolic heart failure 30.0 TNF LGALS3 ACE
7 atrial standstill 1 29.9 PKP2 DSP ACE
8 lyme disease 29.9 TNF IL1B HLA-DQB1
9 endocarditis 29.9 TNF IFNG CXCL8
10 myocarditis 29.8 TNF IL1B IFNG HLA-DQB1 DSP ACE
11 choroiditis 29.8 TNF IFNG ACE
12 toxic shock syndrome 29.6 TNF IL1B IFNG CXCL8
13 extrinsic allergic alveolitis 29.6 IL1B IL15 CXCL8
14 left bundle branch hemiblock 29.6 PKP2 DSP ACE
15 septic arthritis 29.6 TNF IL1B IFNG CXCL8
16 pericarditis 29.6 TNF IL1B IFNG CXCL8 ACE
17 crohn's disease 29.6 TNF IL1B IFNG CXCL8
18 ulcerative colitis 29.6 TNF IL1B IFNG CXCL8
19 apnea, obstructive sleep 29.4 TNF IL1B CXCL8 ACE
20 pulmonary edema 29.4 TNF IL1B CXCL8 ACE
21 sleep apnea 29.4 TNF IL1B CXCL8 ACE
22 pulmonary tuberculosis 29.3 TNF IL1B IL12B IFNG HLA-DQB1
23 lipoprotein quantitative trait locus 29.3 TNF IL1B CXCL8 ACE
24 thrombocytopenia 29.1 TNF PSMB9 IL1B IFNG CXCL8
25 constrictive pericarditis 29.1 ZIC3 IFNG ACE
26 acute myocarditis 29.0 ZIC3 TNF IL1B ACE
27 myocardial infarction 28.8 TNF LGALS3 IL1B IFNG CXCL8 ACE
28 pulmonary disease, chronic obstructive 28.8 TNF IL5 IL1B CXCL8 ACE
29 restrictive cardiomyopathy 28.8 ZIC3 DSP ACE
30 hydrocephalus 28.7 ZIC3 TNF IFNG ACE
31 dilated cardiomyopathy 28.3 TNF PKP2 LGALS3 IL1B IFNG HLA-DQB1
32 lung disease 28.1 TNF IL5 IL1B IL15 IFNG CXCL8
33 heart disease 27.9 ZIC3 TNF PKP2 IL1B DSP CXCL8
34 autoimmune disease 27.6 TNF PSMB9 IL5 IL1B IL15 IL12B
35 atrioventricular block 10.7
36 cardiac conduction defect 10.6
37 beryllium disease 10.6 TNF HLA-DQB1
38 congestive heart failure 10.6
39 autoimmune myocarditis 10.5 TNF IFNG
40 physiological polycythemia 10.5 TNF IL1B
41 spotted fever rickettsiosis 10.5 TNF IFNG
42 polyarticular juvenile idiopathic arthritis 10.5 TNF IFNG
43 idiopathic anterior uveitis 10.5 TNF CXCL8
44 streptococcal toxic-shock syndrome 10.5 TNF CXCL8
45 systemic onset juvenile idiopathic arthritis 10.5 TNF IL1B
46 arrhythmogenic right ventricular cardiomyopathy 10.4
47 vulvar vestibulitis syndrome 10.4 TNF IL1B
48 palladium allergic contact dermatitis 10.4 TNF IL1B
49 kashin-beck disease 10.4 TNF IL1B
50 haemophilus influenzae 10.4 TNF CXCL8

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to Cardiac Sarcoidosis

Symptoms & Phenotypes for Cardiac Sarcoidosis

GenomeRNAi Phenotypes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.61 ACE HLA-DQB1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.61 ACE IL1B PSMB8 PSMB9 TNF ZIC3
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.61 ZIC3
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 CXCL8 IL1B PSMB8 PSMB9 TNF ZIC3
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 ACE CXCL8 HLA-DQB1 IL1B PSMB8 PSMB9

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.18 ACE DSP HLA-DMA HLA-DQB1 IFNG IL12B
2 hematopoietic system MP:0005397 10.18 ACE HLA-DMA HLA-DQB1 IFNG IL12B IL15
3 cardiovascular system MP:0005385 10.16 ACE DSP HLA-DQB1 IFNG IL15 IL1B
4 immune system MP:0005387 10.13 ACE HLA-DMA HLA-DQB1 IFNG IL12B IL15
5 digestive/alimentary MP:0005381 10.03 DSP HLA-DQB1 IFNG IL12B IL5 LGALS3
6 mortality/aging MP:0010768 9.93 ACE DSP HLA-DMA HLA-DQB1 IFNG IL12B
7 liver/biliary system MP:0005370 9.86 ACE HLA-DQB1 IFNG IL5 LGALS3 PSMB9
8 neoplasm MP:0002006 9.61 ACE IFNG IL12B IL1B IL5 LGALS3
9 respiratory system MP:0005388 9.23 HLA-DQB1 IFNG IL12B IL5 LGALS3 PSMB9

Drugs & Therapeutics for Cardiac Sarcoidosis

Drugs for Cardiac Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorodeoxyglucose F18 Phase 4
2 Radiopharmaceuticals Phase 4
3
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
4
leucovorin Approved Phase 3 58-05-9 6006 143
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
6 Hematinics Phase 2, Phase 3
7 Ferrosoferric Oxide Phase 2, Phase 3
8 Pharmaceutical Solutions Phase 2, Phase 3
9 Parenteral Nutrition Solutions Phase 2, Phase 3
10 Antirheumatic Agents Phase 3
11 Immunologic Factors Phase 3
12 Vitamin B Complex Phase 3
13 Folic Acid Antagonists Phase 3
14 Immunosuppressive Agents Phase 3
15 Dermatologic Agents Phase 3
16 Folate Phase 3
17 Vitamin B9 Phase 3
18 Antimetabolites Phase 3
19 Interleukin 1 Receptor Antagonist Protein Phase 2
20
Prednisolone phosphate Approved, Vet_approved 302-25-0
21
Methylprednisolone Approved, Vet_approved 83-43-2 6741
22
Methylprednisolone hemisuccinate Approved 2921-57-5
23
Prednisolone Approved, Vet_approved 50-24-8 5755
24 Prednisolone acetate Approved, Vet_approved 52-21-1
25
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605
26
Prednisolone hemisuccinate Experimental 2920-86-7
27 Edotreotide
28 Methylprednisolone Acetate

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis Recruiting NCT03549598 Phase 4 68Ga-DOTATATE PET/CT;18FDG PET/CT scan;13NH3 PET/CT scan
2 CArdiac Sarcoidosis Response TO steRoids (CASTOR) Trial Withdrawn NCT01210677 Phase 4 Prednisone
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
4 Cardiac Sarcoidosis Multi-Center Randomized Controlled Trial Recruiting NCT03593759 Phase 3 Prednisone;Methotrexate
5 18F-FSPG PET/MRI or PET/CT Imaging of Cardiac Sarcoidosis or Inflammation Recruiting NCT03103490 Phase 2 18F-FSPG
6 Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis Not yet recruiting NCT04017936 Phase 2 Anakinra;Placebos
7 Somatostatin Receptor Imaging in Cardiac Sarcoidosis Unknown status NCT02812849 Cu-64 DOTATATE
8 Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications Unknown status NCT02062008
9 Sub-project: Use of Small Implantable ECG Recorder in Pregnant Women With Arrhythmia Unknown status NCT02249195
10 [18 F]-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET) in Cardiac Sarcoidosis Approved for marketing NCT01764191
11 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Completed NCT02546388 Indium-111 Pentreotide;Gallium-68 DOTATATE
12 Diagnosing Cardiac Sarcoidosis Using FDG PET: Optimization Completed NCT01729169
13 18F-fluorodeoxyglucose Positron Emission Tomography Imaging in Cardiac Sarcoidosis Reveals Characteristic Heterogeneity of Tracer Uptake and the Disease Activity in Myocardium Completed NCT00958087
14 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Myocardial Perfusion Imaging for Evaluation of Cardiac Sarcoidosis Completed NCT03048097 Early Phase 1 Fluorodeoxyglucose;Rubidium
15 Efficacy if Implantable Cardioverter Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis Completed NCT01013311
16 Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis Completed NCT01648933
17 A Randomized Screening Trial for Cardiac Sarcoidosis (CS) in Patients Seen During Routine Clinical Care Who Have Not Been Clinically Suspected to Have (CS), Comparing the Addition of Echocardiogram and Ambulatory ECG to Standard of Care. Recruiting NCT03902223
18 Somatostatin Receptor Imaging in Inflammatory Heart Disease Recruiting NCT04206163
19 Feasibility and Accuracy of Hybrid Magnetic Resonance and Positron Emission Tomography With 18F-Fluorodeoxyglucose in Diagnosing Cardiac Sarcoidosis Recruiting NCT03923049
20 Molecular Imaging in Cardiovascular Disease Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR): Cardiac Sarcoidosis Recruiting NCT03705884 Prednisolone
21 Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis: A Pilot Study Combining Advanced MRI and 18F-FDG and 18F-GE180 PET of the Myocardium Recruiting NCT03561025
22 Cardiac Sarcoidosis Multi-Center Prospective Cohort Study Recruiting NCT01477359
23 Diagnostic and Prognostic Significance of Combined PET/MRI in Inflammatory Cardiomyopathies and Sarcoidosis Recruiting NCT03356756
24 Detection and Prognostic Significance of Myocardial Damage Visualized by Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis Recruiting NCT01745237
25 Cardiomyocyte Specific Cell Free DNA as a Marker of Cardiac Sarcoidosis Recruiting NCT03858777
26 Evaluation of 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging in Myocarditis Recruiting NCT03777839
27 Impact of 100mL Lipid Emulsion for Intravenous for Suppression of Myocardial Glucose Recruiting NCT04437927
28 CASPA (CArdiac Sarcoidosis in PApworth): Improving the Diagnosis of Cardiac Disease in Patients With Pulmonary Sarcoidosis Recruiting NCT03599414
29 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC - a Feasibility Study Recruiting NCT02989480
30 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Active, not recruiting NCT03746847 Gallium-68 DOTATATE
31 Non-Invasive Characterization in Cardiac Sarcoidosis Terminated NCT02017522

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

MalaCards organs/tissues related to Cardiac Sarcoidosis:

40
Heart, Testes, Lung, Lymph Node, Kidney, Monocytes, T Cells

Publications for Cardiac Sarcoidosis

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 1254)
# Title Authors PMID Year
1
Prevalence of atrial FDG uptake and association with atrial arrhythmias in patients with cardiac sarcoidosis. 61
32320785 2020
2
Deterioration of biventricular strain is an early marker of cardiac involvement in confirmed sarcoidosis. 61
31566217 2020
3
Risk of Adverse Cardiovascular Events in Cardiac Sarcoidosis Independent of Left Ventricular Function. 61
32402485 2020
4
Imaging and Quantification of Cardiac Sarcoidosis. 61
32540026 2020
5
Detailed visualization of the right and left ventricular, left atrial, and epicardial involvement of cardiac sarcoidosis with novel semiconductor PET/CT. 61
31713658 2020
6
Cardiac Sarcoidosis: Remembering the Forgotten Right Ventricle. 61
32307252 2020
7
Desmoplakin Cardiomyopathy, a Fibrotic and Inflammatory Form of Cardiomyopathy Distinct From Typical Dilated or Arrhythmogenic Right Ventricular Cardiomyopathy. 61
32372669 2020
8
Cardiac Sarcoidosis and Arrhythmogenic Cardiomyopathy: Distinguishing the Often Indistinguishable. 61
32553222 2020
9
Electroanatomical Voltage Mapping to Distinguish Right-Sided Cardiac Sarcoidosis From Arrhythmogenic Right Ventricular Cardiomyopathy. 61
32553221 2020
10
Anesthetic management of laparoscopy-assisted total proctocolectomy in a cardiac sarcoidosis patient with a cardiac resynchronization therapy-defibrillator: a case report. 61
32506211 2020
11
Novel PET tracers in the management of cardiac sarcoidosis. 61
32484775 2020
12
TNF-alpha inhibition for the treatment of cardiac sarcoidosis. 61
31806154 2020
13
Diagnosis of isolated cardiac sarcoidosis based on new guidelines. 61
32578957 2020
14
Sarcoidosis with cryptococcal infection apparently engaging only immune-privileged body compartments: a case report. 61
32571242 2020
15
Idiopathic giant cell myocarditis or cardiac sarcoidosis? A retrospective audit of a nationwide case series. 61
32343481 2020
16
Waxing and Waning Presentation of Isolated Cardiac Sarcoidosis on Sequential 18F-FDG-PET exams. 61
32518122 2020
17
Myocardial Mapping in Systemic Sarcoidosis: A Comparison of Two Measurement Approaches. 61
32516822 2020
18
Underdiagnosis of VT due to cycle length variation among cardiac sarcoidosis patients having ICD: Problem with stability discriminator. 61
32320087 2020
19
Massive pericardial effusion causing cardiac tamponade accompanied by elevated CA-125 and thoracic lymphadenopathy in sarcoidosis: a case report. 61
32563820 2020
20
Left ventricular thrombus on 18F-FDG and 18F-FLT PET/CT in a patient with cardiac sarcoidosis. 61
32533424 2020
21
A Patient with Cardiac Sarcoidosis in Whom an Abnormal Myocardial Uptake of Fluorine-18 Fluorodeoxyglucose and Sustained Ventricular Tachycardia Recurred 3.5 Years after Discontinuing Oral Corticosteroid Therapy. 61
32536643 2020
22
Performance of diagnostic criteria in patients clinically judged to have cardiac sarcoidosis: Is it time to regroup? 61
32240829 2020
23
A positive Tc-99m PYP scan in a patient with cardiac sarcoidosis. 61
32445166 2020
24
Sarcoidosis diagnosed on granulomas in the explanted heart after transplantation: Results of a French nationwide study. 61
32122700 2020
25
Effect of Corticosteroid Dose and Duration on 18-Fluorodeoxyglucose Positron Emission Tomography in Cardiac Sarcoidosis. 61
31954655 2020
26
Quantitative Assessment of Cardiac Hypermetabolism and Perfusion for Diagnosis of Cardiac Sarcoidosis. 61
32462631 2020
27
Outflow-tract ventricular tachycardia: Can 12 lead ECG during sinus rhythm identify underlying cardiac sarcoidosis? 61
32119909 2020
28
Concurrent cardiac sarcoidosis and obstructive sleep apnea presenting as arrhythmias. 61
32384872 2020
29
Serum angiotensin converting enzyme, Erythrocyte sedimentation rate and high sensitive-C reactive protein levels in diagnosis of cardiac sarcoidosis- where do we stand? 61
32407763 2020
30
Inflammatory cardiomyopathies: short- and long-term outcomes after heart transplantation-a protocol for a systematic review and meta-analysis. 61
31932994 2020
31
Nuclear cardiology: an overview of radioisotope techniques used in the diagnosis of cardiovascular disorders. 61
32469191 2020
32
The chameleon of cardiology: cardiac sarcoidosis before and after heart transplantation. 61
31802644 2020
33
Heart Transplant Outcomes for Patients with Cardiac Sarcoidosis. 61
32464901 2020
34
Tender cutaneous nodules in a patient with cardiac sarcoidosis. 61
31313845 2020
35
Cardiac sarcoidosis: the complementary role of 18F-FDG PET and MRI. 61
31809284 2020
36
Using FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis. 61
30737635 2020
37
Review: Contrast-enhanced magnetic resonance in the diagnosis and management of cardiac sarcoidosis. 61
32330463 2020
38
Management of Cardiac Sarcoidosis Post Heart Transplantation: Survey of Transplant Centers. 61
32465231 2020
39
Prognostic Value of 18F-FDG PET Using Texture Analysis in Cardiac Sarcoidosis. 61
31954654 2020
40
Myocardial Positron Emission Tomography for Evaluation of Cardiac Sarcoidosis: Specialized Protocols for Better Diagnosis. 61
32052608 2020
41
Myocardial Perfusion and Scar Assessment in Cardiac Sarcoidosis With Functional Computed Tomography Imaging. 61
32208732 2020
42
PET/Computed Tomography in Pulmonary and Thoracic Inflammatory Diseases (Including Cardiac Sarcoidosis): The Current Role and Future Promises. 61
32145887 2020
43
Stop that glucose getting to heart! 61
30238300 2020
44
Folate Receptor β Targeted PET Imaging of Macrophages in Autoimmune Myocarditis. 61
32284397 2020
45
Variances of dietary preparation for suppression of physiological 18F-FDG myocardial uptake in the presence of cardiac sarcoidosis: A systematic review. 61
30088196 2020
46
Impact of the inflammation on the outcomes of catheter ablation of drug-refractory ventricular tachycardia in cardiac sarcoidosis. 61
31916658 2020
47
Detection of arrhythmogenic substrate within QRS complex in patients with cardiac sarcoidosis using wavelet-transformed ECG. 61
32185494 2020
48
Imaging cardiac sarcoidosis and infiltrative diseases: diagnosis and therapeutic response. 61
31992689 2020
49
In Which Patients with Sarcoidosis Is FDG PET/CT Indicated? 61
32213991 2020
50
[Sarcoidosis with Cardiac Involvement and Monoclonal Gammopathy]. 61
32394870 2020

Variations for Cardiac Sarcoidosis

Expression for Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for Cardiac Sarcoidosis

Pathways related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 TNF PSMB9 PSMB8 LGALS3 IL5 IL1B
2
Show member pathways
13.52 TNF PSMB9 PSMB8 IL5 IL1B IL15
3
Show member pathways
13.45 ZIC3 TNF PSMB9 PSMB8 PKP2 IL5
4
Show member pathways
13.26 TNF IL5 IL1B IL15 IL12B CXCL8
5
Show member pathways
13.21 TNF PSMB9 PSMB8 IL5 IL1B IL15
6
Show member pathways
13.04 TNF IL1B IL12B IFNG CXCL8 ACE
7
Show member pathways
12.82 TNF IL1B IL12B IFNG HLA-DQB1 HLA-DMA
8 12.81 IL5 IL15 IL12B IFNG CXCL8
9 12.81 TNF IL1B IL12B IFNG HLA-DQB1 HLA-DMA
10
Show member pathways
12.72 TNF IL5 IL1B IL15 IL12B IFNG
11
Show member pathways
12.63 TNF IL12B IFNG HLA-DQB1 HLA-DMA
12 12.57 TNF PSMB8 LGALS3 IL1B IFNG
13
Show member pathways
12.51 TNF IL5 IL1B IL12B IFNG HLA-DQB1
14
Show member pathways
12.5 TNF IL12B IFNG CXCL8
15
Show member pathways
12.36 TNF IL5 IL1B IFNG CXCL8
16 12.32 TNF IL15 HLA-DQB1 HLA-DMA
17
Show member pathways
12.29 TNF IL1B IFNG CXCL8
18
Show member pathways
12.23 TNF IL1B IL12B IFNG HLA-DQB1 HLA-DMA
19
Show member pathways
12.19 TNF IL1B IFNG CXCL8
20 12.19 TNF IL1B IL12B IFNG HLA-DQB1 HLA-DMA
21
Show member pathways
12.18 TNF PSMB8 IL5 IL1B IL15 IL12B
22 12.03 TNF LGALS3 IL1B IFNG CXCL8
23 12.02 TNF IL5 IL15 IFNG
24 12.01 TNF IL1B IL12B CXCL8
25
Show member pathways
11.97 TNF IL1B IL12B IFNG
26
Show member pathways
11.94 IL1B IL12B IFNG
27 11.94 TNF IL1B IL15
28 11.93 TNF IL1B IL12B IFNG CXCL8
29 11.91 IL1B IFNG CXCL8
30 11.9 TNF IL1B CXCL8
31 11.9 TNF IL5 IL1B HLA-DQB1 HLA-DMA
32 11.88 TNF IL1B CXCL8
33
Show member pathways
11.83 IL1B IL12B IFNG
34 11.8 TNF IL1B IL12B CXCL8
35
Show member pathways
11.8 TNF IL5 IFNG CXCL8
36 11.8 TNF IL5 IL1B IL15 IFNG
37 11.78 IL5 IFNG CXCL8
38 11.73 TNF IL1B IFNG
39
Show member pathways
11.71 TNF IL1B IFNG CXCL8
40 11.67 TNF IL1B IL15 IFNG HLA-DQB1 HLA-DMA
41 11.66 TNF IL1B IL12B CXCL8
42 11.6 TNF IL1B IFNG CXCL8
43 11.58 TNF IL1B IL12B CXCL8
44 11.57 TNF IL1B IL12B IFNG
45 11.56 TNF IL1B IL12B IFNG
46 11.53 TNF IL5 IL1B IL12B DSP CXCL8
47 11.5 TNF IL1B IFNG
48 11.42 TNF IL1B IL12B IFNG
49 11.41 PSMB9 IL1B IFNG
50
Show member pathways
11.39 TNF IL15 IFNG

GO Terms for Cardiac Sarcoidosis

Cellular components related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.72 TNF LGALS3 IL15 IL12B HLA-DMA
2 extracellular region GO:0005576 9.61 TNF LGALS3 IL5 IL1B IL15 IL12B
3 extracellular space GO:0005615 9.28 TNF LGALS3 IL5 IL1B IL15 IL12B
4 proteasome core complex, beta-subunit complex GO:0019774 9.26 PSMB9 PSMB8
5 spermatoproteasome complex GO:1990111 9.16 PSMB9 PSMB8

Biological processes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10 TNF IL5 IL1B IL15 CXCL8
2 cytokine-mediated signaling pathway GO:0019221 9.93 TNF IL5 IL1B IL12B CXCL8
3 cellular response to lipopolysaccharide GO:0071222 9.91 TNF IL1B IL12B CXCL8
4 MAPK cascade GO:0000165 9.88 TNF PSMB9 PSMB8 IL5 IL1B
5 interleukin-1-mediated signaling pathway GO:0070498 9.87 PSMB9 PSMB8 IL1B
6 neutrophil chemotaxis GO:0030593 9.85 LGALS3 IL1B CXCL8
7 regulation of insulin secretion GO:0050796 9.85 TNF IL1B IFNG
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF IL1B IL12B
9 positive regulation of T cell proliferation GO:0042102 9.82 IL1B IL15 IL12B
10 positive regulation of protein localization to plasma membrane GO:1903078 9.8 TNF LGALS3 IFNG
11 positive regulation of protein complex assembly GO:0031334 9.79 TNF LGALS3 IFNG
12 positive regulation of interferon-gamma production GO:0032729 9.77 TNF IL1B IL12B
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.75 TNF IL1B IFNG
14 antigen processing and presentation GO:0019882 9.74 PSMB8 HLA-DQB1 HLA-DMA
15 positive regulation of interleukin-6 secretion GO:2000778 9.73 TNF IL1B IFNG
16 negative regulation of smooth muscle cell proliferation GO:0048662 9.72 IL15 IL12B IFNG
17 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 TNF IL1B
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 TNF IL1B
19 positive regulation of interleukin-17 production GO:0032740 9.7 IL15 IL12B
20 negative regulation of interleukin-17 production GO:0032700 9.7 IL12B IFNG
21 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL1B
22 positive regulation of podosome assembly GO:0071803 9.69 TNF IL5
23 neutrophil activation GO:0042119 9.69 IL15 CXCL8
24 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.68 PKP2 DSP
25 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL1B IL12B
26 negative regulation of amyloid-beta clearance GO:1900222 9.68 TNF IFNG
27 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.67 TNF IFNG
28 regulation of establishment of endothelial barrier GO:1903140 9.67 TNF IL1B
29 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 TNF IL15 IL12B IFNG
30 regulation of defense response to virus by host GO:0050691 9.66 IL1B IL15
31 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.66 IL12B IFNG
32 positive regulation of natural killer cell proliferation GO:0032819 9.65 IL15 IL12B
33 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.64 PKP2 DSP
34 positive regulation of mononuclear cell migration GO:0071677 9.64 TNF LGALS3
35 positive regulation of tissue remodeling GO:0034105 9.63 IL15 IL12B
36 desmosome organization GO:0002934 9.63 PKP2 DSP
37 positive regulation of osteoclast differentiation GO:0045672 9.63 TNF IL12B IFNG
38 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
39 astrocyte activation GO:0048143 9.61 TNF IL1B IFNG
40 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
41 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNF IL1B IFNG
42 positive regulation of phagocytosis GO:0050766 9.56 TNF IL1B IL15 IFNG
43 positive regulation of inflammatory response GO:0050729 9.55 TNF IL1B IL15 IL12B IFNG
44 negative regulation of gap junction assembly GO:1903597 9.52 IL1B ACE
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 TNF IFNG
46 positive regulation of chemokine biosynthetic process GO:0045080 9.5 TNF IL1B IFNG
47 positive regulation of nitrogen compound metabolic process GO:0051173 9.49 TNF IFNG
48 immune response GO:0006955 9.23 TNF IL5 IL1B IL15 IFNG HLA-DQB1
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.13 TNF IL1B IFNG

Molecular functions related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.03 ZIC3 TNF PSMB9 PSMB8 PKP2 LGALS3
2 endopeptidase activity GO:0004175 9.43 PSMB9 PSMB8 ACE
3 cytokine activity GO:0005125 9.17 TNF IL5 IL1B IL15 IL12B IFNG
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.96 PKP2 DSP

Sources for Cardiac Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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