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MCID: CRD217
MIFTS: 27

Cardiac Tuberculosis

Categories: Cardiovascular diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cardiac Tuberculosis

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MalaCards integrated aliases for Cardiac Tuberculosis:

Name: Cardiac Tuberculosis 12 15
Tuberculosis, Cardiovascular 43 17 71
Cardiovascular Tuberculosis 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060570
MeSH 43 D014381
UMLS 71 C0041308
Sources

Summaries for Cardiac Tuberculosis

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MalaCards based summary : Cardiac Tuberculosis, also known as tuberculosis, cardiovascular, is related to myocardial infarction and mycobacterium tuberculosis 1. An important gene associated with Cardiac Tuberculosis is EHD1 (EH Domain Containing 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Isoniazid and Hypolipidemic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and small intestine.

Sources

Related Diseases for Cardiac Tuberculosis

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Diseases related to Cardiac Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 28.6 SERPINE1 SERPINC1 CRP
2 mycobacterium tuberculosis 1 10.1
3 pulmonary tuberculosis 10.0
4 tuberculous epididymitis 10.0 EHD1 CRP
5 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.0 SERPINE1 CRP
6 meckel diverticulum 10.0 SERPINE1 CRP
7 ureteral disease 10.0 SERPINE1 CRP
8 chronic venous insufficiency 9.9 SERPINE1 CRP
9 venous insufficiency 9.9 SERPINE1 CRP
10 apnea, obstructive sleep 9.9 SERPINE1 CRP
11 endocrine pancreas disease 9.9 SERPINE1 CRP
12 paranasal sinus disease 9.9 SERPINE1 CRP
13 infective endocarditis 9.9 SERPINE1 CRP
14 coronary stenosis 9.9 SERPINE1 CRP
15 urinary tract obstruction 9.9 SERPINE1 CRP
16 fibrinolytic defect 9.9 SERPINE1 SERPINC1
17 familial hyperlipidemia 9.9 SERPINE1 CRP
18 sticky platelet syndrome 9.9 SERPINE1 SERPINC1
19 dic in newborn 9.9 SERPINE1 SERPINC1
20 livedoid vasculitis 9.9 SERPINE1 SERPINC1
21 peritonitis 9.9 SERPINE1 CRP
22 meningococcemia 9.8 SERPINE1 SERPINC1
23 retinal artery occlusion 9.8 SERPINE1 SERPINC1
24 argentine hemorrhagic fever 9.8 SERPINE1 SERPINC1
25 carotid artery thrombosis 9.8 SERPINE1 SERPINC1
26 post-thrombotic syndrome 9.8 SERPINE1 SERPINC1
27 coronary heart disease 1 9.8 SERPINE1 CRP
28 thrombophilia due to activated protein c resistance 9.8 SERPINE1 SERPINC1
29 thrombophilia 9.8 SERPINE1 SERPINC1
30 myocarditis 9.8
31 factor xiii deficiency 9.8 SERPINE1 SERPINC1
32 legg-calve-perthes disease 9.8 SERPINE1 SERPINC1
33 coronary thrombosis 9.8 SERPINE1 SERPINC1
34 protein s deficiency 9.8 SERPINE1 SERPINC1
35 overnutrition 9.8 SERPINE1 CRP
36 eclampsia 9.8 SERPINE1 SERPINC1
37 protein c deficiency 9.8 SERPINE1 SERPINC1
38 lipid metabolism disorder 9.8 SERPINE1 CRP
39 hepatic veno-occlusive disease 9.8 SERPINE1 SERPINC1
40 thrombophilia due to thrombin defect 9.8 SERPINE1 SERPINC1
41 blue toe syndrome 9.8 SERPINC1 CRP
42 cavernous sinus thrombosis 9.8 SERPINC1 CRP
43 marantic endocarditis 9.8 SERPINC1 CRP
44 retinal vein occlusion 9.8 SERPINE1 SERPINC1
45 interstitial lung disease 9.8 SERPINE1 CRP
46 intracranial sinus thrombosis 9.8 SERPINC1 CRP
47 cholesterol embolism 9.8 SERPINC1 CRP
48 intracranial hypertension 9.8 SERPINE1 SERPINC1
49 branch retinal artery occlusion 9.8 SERPINC1 CRP
50 intracranial embolism 9.8 SERPINC1 CRP

Graphical network of the top 20 diseases related to Cardiac Tuberculosis:



Diseases related to Cardiac Tuberculosis
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Symptoms & Phenotypes for Cardiac Tuberculosis

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Drugs & Therapeutics for Cardiac Tuberculosis

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Drugs for Cardiac Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational 54-85-3 3767
2 Hypolipidemic Agents
3 Antitubercular Agents
4 Anti-Infective Agents
5 Antimetabolites
6 Lipid Regulating Agents
7 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Study of Interventions to Enhance Adherence to Isoniazid Prevention Therapy for Tuberculosis in Injection Drug Users Unknown status NCT00004740 isoniazid

Search NIH Clinical Center for Cardiac Tuberculosis

Cochrane evidence based reviews: tuberculosis, cardiovascular

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Genetic Tests for Cardiac Tuberculosis

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Anatomical Context for Cardiac Tuberculosis

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MalaCards organs/tissues related to Cardiac Tuberculosis:

40
Heart, Lung, Small Intestine, Pancreas, Placenta
Sources

Publications for Cardiac Tuberculosis

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Articles related to Cardiac Tuberculosis:

(show all 23)
# Title Authors PMID Year
1
Acute myocarditis secondary to cardiac tuberculosis: a case report. 61
28814447 2017
2
Assessing the burden of medical impoverishment by cause: a systematic breakdown by disease in Ethiopia. 61
27769296 2016
3
An unusual cardiac mass: Echocardiography, computed tomography, and magnetic resonance imaging. 61
30546629 2016
4
Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study. 61
28144367 2016
5
Patterns of mortality in public and private hospitals of Addis Ababa, Ethiopia. 61
23167315 2012
6
Loss of left ventricular torsion as the predominant mechanism of left ventricular systolic dysfunction in a patient with tubercular cardiomyopathy. 61
22748130 2012
7
A rare disappearing right atrial mass. 61
22535544 2012
8
Intracardiac left atrial tuberculoma in an eleven-month-old infant: case report. 61
22208878 2011
9
Diffuse infiltrative cardiac tuberculosis. 61
21677817 2011
10
Bicaval obstruction complicating right atrial tuberculoma: the diagnostic value of cardiovascular MR. 61
19099600 2008
11
Cardiac tuberculosis with multiple intracardiac masses: a case report. 61
12094179 2002
12
Cardiac tuberculosis presenting as small intestinal gangrene. 61
12036536 2002
13
Bloody pericardial effusion in patients with cardiac tamponade: is the cause cancerous, tuberculous, or iatrogenic in the 1990s? 61
10593777 1999
14
Images in cardiovascular medicine. Cardiac tuberculosis. 61
9715867 1998
15
[Isolated tuberculosis of the heart: a clinical and echocardiography follow-up]. 61
9133119 1997
16
Recurrence of two myocardial aneurysms infected with tuberculosis after a previous aneurysmectomy. 61
2805463 1989
17
Cardiac tuberculosis. A study of 19 patients. 61
3566473 1987
18
Medical aspects of head and neck cancer. 61
4052833 1985
19
Cardiac tuberculosis: TB of the endocardium. 61
6731481 1984
20
[Myocobacterium tuberculosis endomyocarditis. Apropos of a case in a patient with a mitral valve prosthesis]. 61
6818922 1982
21
[Cardiac tuberculosis]. 61
13484939 1957
22
[Cardiac tuberculosis simulating myocardial infarction]. 61
14891260 1951
23
Some aspects of the pathogenesis of cardiac tuberculosis. 61
20254319 1947
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Variations for Cardiac Tuberculosis

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Expression for Cardiac Tuberculosis

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Search GEO for disease gene expression data for Cardiac Tuberculosis.
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Pathways for Cardiac Tuberculosis

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Pathways related to Cardiac Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.16 SERPINE1 SERPINC1
2
Complement and coagulation cascades 1 36
10.78 SERPINE1 SERPINC1
Sources

GO Terms for Cardiac Tuberculosis

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Biological processes related to Cardiac Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endopeptidase activity GO:0010951 8.96 SERPINE1 SERPINC1
2 negative regulation of peptidase activity GO:0010466 8.62 SERPINE1 SERPINC1

Molecular functions related to Cardiac Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 9.16 SERPINE1 SERPINC1
2 protease binding GO:0002020 8.96 SERPINE1 SERPINC1
3 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPINE1 SERPINC1
Sources

Sources for Cardiac Tuberculosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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