Cardiomyopathy, Familial Hypertrophic, 6 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRD232 MIFTS: 36	Cardiomyopathy, Familial Hypertrophic, 6 Categories: Genetic diseases, Cardiovascular diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Download Expand all tables

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Aliases & Classifications for Cardiomyopathy, Familial Hypertrophic, 6

MalaCards integrated aliases for Cardiomyopathy, Familial Hypertrophic, 6:

Name: Cardiomyopathy, Familial Hypertrophic, 6 ⁵⁷ ⁷³

Cardiomyopathy, Familial Hypertrophic 6 ¹² ⁷⁵ ¹³

Cmh6 ⁵⁷ ¹² ⁷⁵

Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome ⁷⁵ ⁶

Familial Hypertrophic Cardiomyopathy 6 ²⁹ ⁶

Hypertrophic Cardiomyopathy 6 ¹² ¹⁵

Cardiomyopathy, Hypertrophic, Familial, Type 6 ⁴⁰

Cardiomyopathy, Hypertrophic 6 ⁵⁷

Characteristics:

OMIM:

⁵⁷

Inheritance:
autosomal dominant

Miscellaneous:
genetic heterogeneity (see )

HPO:

³²

cardiomyopathy, familial hypertrophic, 6:
Inheritance autosomal dominant inheritance heterogeneous

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 600858

Disease Ontology ¹² DOID:0110312

MedGen ⁴² C1833236

MeSH ⁴⁴ D024741

SNOMED-CT via HPO ⁶⁹ 263681008 233873004 45227007 more

UMLS ⁷³ C1833236

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Summaries for Cardiomyopathy, Familial Hypertrophic, 6

UniProtKB/Swiss-Prot : ⁷⁵ Cardiomyopathy, familial hypertrophic 6: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH6 patients present Wolff-Parkinson-White ventricular preexcitation, enlarged myocytes without myofiber disarray, and glycogen-containing cytosolic vacuoles within cardiomyocytes.

MalaCards based summary : Cardiomyopathy, Familial Hypertrophic, 6, also known as cardiomyopathy, familial hypertrophic 6, is related to wolff-parkinson-white syndrome and hypertrophic cardiomyopathy. An important gene associated with Cardiomyopathy, Familial Hypertrophic, 6 is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways/superpathways are Cardiac conduction and Dilated cardiomyopathy (DCM). Affiliated tissues include heart and skeletal muscle, and related phenotypes are hypertrophic cardiomyopathy and asymmetric septal hypertrophy

Disease Ontology : ¹² A hypertrophic cardiomyopathy that has material basis in heterozygous mutation in the gene encoding the gamma-2 regulatory subunit of AMP-activated protein kinase (PRKAG2).

OMIM : ⁵⁷ Mutations in the PRKAG2 gene (602743) give rise to a moderate, essentially heart-specific, nonlysosomal glycogenosis with clinical onset typically in late adolescence or in the third decade of life, ventricular pre-excitation predisposing to supraventricular arrhythmias, mild-to-severe cardiac hypertrophy, enhanced risk of sudden cardiac death in midlife, and autosomal dominant inheritance with full penetrance (summary by Burwinkel et al., 2005). (600858)

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Related Diseases for Cardiomyopathy, Familial Hypertrophic, 6

Diseases in the Hypertrophic Cardiomyopathy family:

Cardiomyopathy, Familial Hypertrophic, 2	Cardiomyopathy, Familial Hypertrophic, 3
Cardiomyopathy, Familial Hypertrophic, 4	Cardiomyopathy, Familial Hypertrophic, 1
Cardiomyopathy, Infantile Hypertrophic	Cardiomyopathy, Familial Hypertrophic, 6
Cardiomyopathy, Familial Hypertrophic, 25	Cardiomyopathy, Familial Hypertrophic, 8
Cardiomyopathy, Familial Hypertrophic, 10	Cardiomyopathy, Familial Hypertrophic, 11
Cardiomyopathy, Familial Hypertrophic, 12	Cardiomyopathy, Familial Hypertrophic, 13
Cardiomyopathy, Familial Hypertrophic, 14	Cardiomyopathy, Familial Hypertrophic, 15
Cardiomyopathy, Familial Hypertrophic, 7	Cardiomyopathy, Familial Hypertrophic, 9
Cardiomyopathy, Familial Hypertrophic, 16	Cardiomyopathy, Familial Hypertrophic, 17
Cardiomyopathy, Familial Hypertrophic, 18	Cardiomyopathy, Familial Hypertrophic, 19
Cardiomyopathy, Familial Hypertrophic, 20	Cardiomyopathy, Familial Hypertrophic, 21
Cardiomyopathy, Familial Hypertrophic, 26	Hypertrophic Cardiomyopathy Due to Intensive Athletic Training

Diseases related to Cardiomyopathy, Familial Hypertrophic, 6 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	wolff-parkinson-white syndrome	30.3	PRKAG2 TNNI3
2	hypertrophic cardiomyopathy	29.7	PRKAG2 TNNI3
3	fabry disease	9.8	PRKAG2 TNNI3
4	atrial standstill 1	9.7	PRKAG2 TNNI3

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Symptoms & Phenotypes for Cardiomyopathy, Familial Hypertrophic, 6

Symptoms via clinical synopsis from OMIM:

⁵⁷

Cardiovascular Heart:
hypertrophic cardiomyopathy
wolff-parkinson-white ventricular preexcitation
sinus bradycardia
atrioventricular block
left bundle branch block
more

Muscle Soft Tissue:
glycogenosis of skeletal muscle, mild (in some patients)

Clinical features from OMIM:

600858

Human phenotypes related to Cardiomyopathy, Familial Hypertrophic, 6:

³² (show all 8)

#	Description	HPO Source Accession
1	hypertrophic cardiomyopathy ³²	HP:0001639
2	asymmetric septal hypertrophy ³²	HP:0001670
3	atrioventricular block ³²	HP:0001678
4	sinus bradycardia ³²	HP:0001688
5	wolff-parkinson-white syndrome ³²	HP:0001716
6	ventricular preexcitation ³²	HP:0004309
7	atrial fibrillation ³²	HP:0005110
8	left bundle branch block ³²	HP:0011713

MGI Mouse Phenotypes related to Cardiomyopathy, Familial Hypertrophic, 6:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.26	LMOD2 PRKAG2 TMOD1 TNNI3
2	muscle	MP:0005369	8.92	LMOD2 PRKAG2 TMOD1 TNNI3

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Drugs & Therapeutics for Cardiomyopathy, Familial Hypertrophic, 6

Search Clinical Trials , NIH Clinical Center for Cardiomyopathy, Familial Hypertrophic, 6

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Genetic Tests for Cardiomyopathy, Familial Hypertrophic, 6

Genetic tests related to Cardiomyopathy, Familial Hypertrophic, 6:

#	Genetic test	Affiliating Genes
1	Familial Hypertrophic Cardiomyopathy 6 ²⁹	PRKAG2

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Anatomical Context for Cardiomyopathy, Familial Hypertrophic, 6

MalaCards organs/tissues related to Cardiomyopathy, Familial Hypertrophic, 6:

⁴¹

Heart, Skeletal Muscle

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Publications for Cardiomyopathy, Familial Hypertrophic, 6

Articles related to Cardiomyopathy, Familial Hypertrophic, 6:

#	Title	Authors	Year
1	Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome progressing to ventricular dilation. ( 8644606 )	Shibata M....Nakano T.	1996
2	Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3. ( 7657794 )	Macrae C.A....Rowland E.	1995

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Genes for Cardiomyopathy, Familial Hypertrophic, 6

Genes related to Cardiomyopathy, Familial Hypertrophic, 6 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1328.02	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative variation ⁷⁵ Genetic Tests ²⁹ GeneCards inferred via : Disorders Variants (show sections)	20301725 21267010 23788249 (more) 25173338 25356965 27854360 11371514 11827995 7657794 15673802 18403758 16487706 19787389 10820940 11586962 10355918
2	TNNI3	Troponin I3, Cardiac Type	Protein Coding	25	Risk factor ⁶
3	LMOD1	Leiomodin 1	Protein Coding	16.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	LMOD2	Leiomodin 2	Protein Coding	8.02	DISEASES inferred ¹⁵
5	TMOD1	Tropomodulin 1	Protein Coding	7.41	DISEASES inferred ¹⁵

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Variations for Cardiomyopathy, Familial Hypertrophic, 6

UniProtKB/Swiss-Prot genetic disease variations for Cardiomyopathy, Familial Hypertrophic, 6:

⁷⁵

#	Symbol	AA change	Variation ID	SNP ID
1	PRKAG2	p.Arg302Gln	VAR_013264	rs121908987
2	PRKAG2	p.His383Arg	VAR_013266	rs121908988
3	PRKAG2	p.Thr400Asn	VAR_013267	rs28938173
4	PRKAG2	p.Asn488Ile	VAR_013268	rs121908989

ClinVar genetic disease variations for Cardiomyopathy, Familial Hypertrophic, 6:

⁶

(show top 50) (show all 168)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PRKAG2	NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln)	single nucleotide variant	Pathogenic	rs121908987	GRCh37	Chromosome 7, 151273498: 151273498
2	PRKAG2	NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln)	single nucleotide variant	Pathogenic	rs121908987	GRCh38	Chromosome 7, 151576412: 151576412
3	PRKAG2	NM_016203.3(PRKAG2): c.1050_1051insTTA (p.Arg350_Glu351insLeu)	insertion	Pathogenic	rs587776643	GRCh37	Chromosome 7, 151269750: 151269751
4	PRKAG2	NM_016203.3(PRKAG2): c.1050_1051insTTA (p.Arg350_Glu351insLeu)	insertion	Pathogenic	rs587776643	GRCh38	Chromosome 7, 151572664: 151572665
5	PRKAG2	NM_016203.3(PRKAG2): c.1199C> A (p.Thr400Asn)	single nucleotide variant	Likely pathogenic	rs28938173	GRCh37	Chromosome 7, 151265836: 151265836
6	PRKAG2	NM_016203.3(PRKAG2): c.1199C> A (p.Thr400Asn)	single nucleotide variant	Likely pathogenic	rs28938173	GRCh38	Chromosome 7, 151568750: 151568750
7	PRKAG2	NM_016203.3(PRKAG2): c.1463A> T (p.Asn488Ile)	single nucleotide variant	Pathogenic	rs121908989	GRCh37	Chromosome 7, 151261285: 151261285
8	PRKAG2	NM_016203.3(PRKAG2): c.1463A> T (p.Asn488Ile)	single nucleotide variant	Pathogenic	rs121908989	GRCh38	Chromosome 7, 151564199: 151564199
9	PRKAG2	NM_016203.3(PRKAG2): c.1459T> C (p.Tyr487His)	single nucleotide variant	Pathogenic	rs267606976	GRCh37	Chromosome 7, 151261289: 151261289
10	PRKAG2	NM_016203.3(PRKAG2): c.1459T> C (p.Tyr487His)	single nucleotide variant	Pathogenic	rs267606976	GRCh38	Chromosome 7, 151564203: 151564203
11	PRKAG2	NM_016203.3(PRKAG2): c.1589A> G (p.His530Arg)	single nucleotide variant	Pathogenic	rs267606977	GRCh37	Chromosome 7, 151257699: 151257699
12	PRKAG2	NM_016203.3(PRKAG2): c.1589A> G (p.His530Arg)	single nucleotide variant	Pathogenic	rs267606977	GRCh38	Chromosome 7, 151560613: 151560613
13	PRKAG2	NM_016203.3(PRKAG2): c.1516G> C (p.Glu506Gln)	single nucleotide variant	Likely pathogenic	rs267606978	GRCh37	Chromosome 7, 151261232: 151261232
14	PRKAG2	NM_016203.3(PRKAG2): c.1516G> C (p.Glu506Gln)	single nucleotide variant	Likely pathogenic	rs267606978	GRCh38	Chromosome 7, 151564146: 151564146
15	PRKAG2	NM_016203.3(PRKAG2): c.1642T> C (p.Ser548Pro)	single nucleotide variant	Pathogenic	rs267606979	GRCh37	Chromosome 7, 151257646: 151257646
16	PRKAG2	NM_016203.3(PRKAG2): c.1642T> C (p.Ser548Pro)	single nucleotide variant	Pathogenic	rs267606979	GRCh38	Chromosome 7, 151560560: 151560560
17	TNNI3	NM_000363.4(TNNI3): c.244C> T (p.Pro82Ser)	single nucleotide variant	risk factor	rs77615401	GRCh37	Chromosome 19, 55667607: 55667607
18	TNNI3	NM_000363.4(TNNI3): c.244C> T (p.Pro82Ser)	single nucleotide variant	risk factor	rs77615401	GRCh38	Chromosome 19, 55156239: 55156239
19	PRKAG2	NM_016203.3(PRKAG2): c.879C> A (p.Phe293Leu)	single nucleotide variant	Likely pathogenic	rs193922697	GRCh37	Chromosome 7, 151273524: 151273524
20	PRKAG2	NM_016203.3(PRKAG2): c.879C> A (p.Phe293Leu)	single nucleotide variant	Likely pathogenic	rs193922697	GRCh38	Chromosome 7, 151576438: 151576438
21	TNNI3	NM_000363.4(TNNI3): c.372+7C> T	single nucleotide variant	Conflicting interpretations of pathogenicity	rs367809676	GRCh37	Chromosome 19, 55666102: 55666102
22	TNNI3	NM_000363.4(TNNI3): c.372+7C> T	single nucleotide variant	Conflicting interpretations of pathogenicity	rs367809676	GRCh38	Chromosome 19, 55154734: 55154734
23	PRKAG2	NM_016203.3(PRKAG2): c.202G> A (p.Gly68Ser)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs730880970	GRCh38	Chromosome 7, 151781416: 151781416
24	PRKAG2	NM_016203.3(PRKAG2): c.202G> A (p.Gly68Ser)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs730880970	GRCh37	Chromosome 7, 151478502: 151478502
25	TNNI3	NM_000363.4(TNNI3): c.*35C> T	single nucleotide variant	Conflicting interpretations of pathogenicity	rs375447438	GRCh38	Chromosome 19, 55151799: 55151799
26	TNNI3	NM_000363.4(TNNI3): c.*35C> T	single nucleotide variant	Conflicting interpretations of pathogenicity	rs375447438	GRCh37	Chromosome 19, 55663167: 55663167
27	PRKAG2	NM_016203.3(PRKAG2): c.1310C> G (p.Ala437Gly)	single nucleotide variant	Uncertain significance	rs762111172	GRCh38	Chromosome 7, 151565809: 151565809
28	PRKAG2	NM_016203.3(PRKAG2): c.1310C> G (p.Ala437Gly)	single nucleotide variant	Uncertain significance	rs762111172	GRCh37	Chromosome 7, 151262895: 151262895
29	PRKAG2	NM_016203.3(PRKAG2): c.-26C> T	single nucleotide variant	Likely benign	rs66628686	GRCh37	Chromosome 7, 151573731: 151573731
30	PRKAG2	NM_016203.3(PRKAG2): c.-26C> T	single nucleotide variant	Likely benign	rs66628686	GRCh38	Chromosome 7, 151876646: 151876646
31	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1440-8A> G	single nucleotide variant	Benign/Likely benign	rs28377509	GRCh37	Chromosome 19, 55670825: 55670825
32	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1440-8A> G	single nucleotide variant	Benign/Likely benign	rs28377509	GRCh38	Chromosome 19, 55159457: 55159457
33	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1365-14C> T	single nucleotide variant	Benign/Likely benign	rs60176657	GRCh38	Chromosome 19, 55159621: 55159621
34	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1365-14C> T	single nucleotide variant	Benign/Likely benign	rs60176657	GRCh37	Chromosome 19, 55670989: 55670989
35	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1257G> A (p.Pro419=)	single nucleotide variant	Benign/Likely benign	rs891187	GRCh37	Chromosome 19, 55671374: 55671374
36	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1257G> A (p.Pro419=)	single nucleotide variant	Benign/Likely benign	rs891187	GRCh38	Chromosome 19, 55160006: 55160006
37	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1205T> C (p.Leu402Pro)	single nucleotide variant	Benign/Likely benign	rs890871	GRCh37	Chromosome 19, 55672055: 55672055
38	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1205T> C (p.Leu402Pro)	single nucleotide variant	Benign/Likely benign	rs890871	GRCh38	Chromosome 19, 55160687: 55160687
39	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1079A> G (p.Glu360Gly)	single nucleotide variant	Benign/Likely benign	rs2365725	GRCh38	Chromosome 19, 55161102: 55161102
40	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.1079A> G (p.Glu360Gly)	single nucleotide variant	Benign/Likely benign	rs2365725	GRCh37	Chromosome 19, 55672470: 55672470
41	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.994-14C> T	single nucleotide variant	Benign/Likely benign	rs7260371	GRCh37	Chromosome 19, 55672569: 55672569
42	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.994-14C> T	single nucleotide variant	Benign/Likely benign	rs7260371	GRCh38	Chromosome 19, 55161201: 55161201
43	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.870T> C (p.Ala290=)	single nucleotide variant	Benign/Likely benign	rs7260320	GRCh37	Chromosome 19, 55672784: 55672784
44	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.870T> C (p.Ala290=)	single nucleotide variant	Benign/Likely benign	rs7260320	GRCh38	Chromosome 19, 55161416: 55161416
45	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.733G> A (p.Gly245Ser)	single nucleotide variant	Benign/Likely benign	rs58824375	GRCh37	Chromosome 19, 55673145: 55673145
46	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.733G> A (p.Gly245Ser)	single nucleotide variant	Benign/Likely benign	rs58824375	GRCh38	Chromosome 19, 55161777: 55161777
47	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.714A> G (p.Val238=)	single nucleotide variant	Benign/Likely benign	rs56726774	GRCh38	Chromosome 19, 55161796: 55161796
48	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.714A> G (p.Val238=)	single nucleotide variant	Benign/Likely benign	rs56726774	GRCh37	Chromosome 19, 55673164: 55673164
49	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.531A> G (p.Arg177=)	single nucleotide variant	Benign/Likely benign	rs3848618	GRCh37	Chromosome 19, 55673654: 55673654
50	DNAAF3; TNNI3	NM_001256714.1(DNAAF3): c.531A> G (p.Arg177=)	single nucleotide variant	Benign/Likely benign	rs3848618	GRCh38	Chromosome 19, 55162286: 55162286

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Expression for Cardiomyopathy, Familial Hypertrophic, 6

Search GEO for disease gene expression data for Cardiomyopathy, Familial Hypertrophic, 6.

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Pathways for Cardiomyopathy, Familial Hypertrophic, 6

Pathways related to Cardiomyopathy, Familial Hypertrophic, 6 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cardiac conduction ⁶⁶ Show member pathways Classical Kir channels ⁶⁶ Ion homeostasis ⁶⁶ Ion transport by P-type ATPases ⁶⁶ Muscle contraction ⁶⁶ Phase 1 - inactivation of fast Na+ channels ⁶⁶ Phase 3 - rapid repolarisation ⁶⁶ Phase 4 - resting membrane potential ⁶⁶ Physiological factors ⁶⁶ Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) ⁶⁶ Tandem pore domain halothane-inhibited K+ channel (THIK) ⁶⁶ Tandem pore domain potassium channels ⁶⁶ TWIK related potassium channel (TREK) ⁶⁶ TWIK-related alkaline pH activated K+ channel (TALK) ⁶⁶ TWIK-related spinal cord K+ channel (TRESK) ⁶⁶ TWIK-releated acid-sensitive K+ channel (TASK) ⁶⁶	11.86	LMOD1 TMOD1 TNNI3
2	Dilated cardiomyopathy (DCM) ³⁷ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁷	11.39	PRKAG2 TNNI3
3	Striated Muscle Contraction ¹ ⁶⁶	10.48	TMOD1 TNNI3

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GO Terms for Cardiomyopathy, Familial Hypertrophic, 6

Cellular components related to Cardiomyopathy, Familial Hypertrophic, 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	actin filament	GO:0005884	9.43	LMOD1 LMOD2 TMOD1
2	striated muscle thin filament	GO:0005865	9.33	LMOD1 LMOD2 TMOD1
3	sarcomere	GO:0030017	9.26	LMOD1 LMOD2 TMOD1 TNNI3
4	myofibril	GO:0030016	8.92	LMOD1 LMOD2 TMOD1 TNNI3

Biological processes related to Cardiomyopathy, Familial Hypertrophic, 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	muscle contraction	GO:0006936	9.46	LMOD1 LMOD2 TMOD1 TNNI3
2	actin filament organization	GO:0007015	9.43	LMOD1 LMOD2 TMOD1
3	positive regulation of actin filament polymerization	GO:0030838	9.4	LMOD1 LMOD2
4	muscle filament sliding	GO:0030049	9.37	TMOD1 TNNI3
5	actin nucleation	GO:0045010	9.32	LMOD1 LMOD2
6	myofibril assembly	GO:0030239	9.13	LMOD1 LMOD2 TMOD1
7	pointed-end actin filament capping	GO:0051694	8.8	LMOD1 LMOD2 TMOD1

Molecular functions related to Cardiomyopathy, Familial Hypertrophic, 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	actin binding	GO:0003779	9.26	LMOD1 LMOD2 TMOD1 TNNI3
2	actin filament binding	GO:0051015	9.16	TMOD1 TNNI3
3	tropomyosin binding	GO:0005523	8.8	LMOD1 LMOD2 TMOD1

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Sources for Cardiomyopathy, Familial Hypertrophic, 6

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⁶¹ PharmGKB

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⁶⁸ SNOMED-CT

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⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia