MCID: CRD118
MIFTS: 42

Cardiovascular Cancer

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Cardiovascular Cancer

MalaCards integrated aliases for Cardiovascular Cancer:

Name: Cardiovascular Cancer 12 54 15
Cardiovascular Neoplasm 12
Cardiovascular Tumors 12

Classifications:



External Ids:

Disease Ontology 12 DOID:176
NCIt 49 C4784
UMLS 71 C0497243

Summaries for Cardiovascular Cancer

Disease Ontology : 12 An organ system cancer that located in the heart and blood vessels.

MalaCards based summary : Cardiovascular Cancer, also known as cardiovascular neoplasm, is related to heart cancer and vascular cancer. An important gene associated with Cardiovascular Cancer is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. The drugs Olive and Sunflower have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thymus, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Cardiovascular Cancer

Diseases related to Cardiovascular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
# Related Disease Score Top Affiliating Genes
1 heart cancer 31.8 TSC2 SERPINA3 PTH1R PECAM1 KIT CD34
2 vascular cancer 30.0 WWTR1 VEGFA TSC2 TP53 TFE3 SERPINA3
3 skin epithelioid hemangioma 10.7 PECAM1 CD34
4 central nervous system angiosarcoma 10.7 PECAM1 CD34
5 spinal cord sarcoma 10.7 KIT CD34
6 penis sarcoma 10.7 MLANA CD34
7 heart fibrosarcoma 10.7 PECAM1 CD34
8 gallbladder leiomyoma 10.7 KIT CD34
9 central nervous system hemangioma 10.7 PECAM1 CD34
10 breast myofibroblastoma 10.7 CD34 CALD1
11 pulmonary vein leiomyosarcoma 10.7 CD34 CALD1
12 ovarian angiosarcoma 10.7 PECAM1 CD34
13 urethra leiomyoma 10.7 KIT CALD1
14 breast hemangiopericytoma 10.7 KIT CD34
15 small intestinal sarcoma 10.7 KIT CD34
16 small intestine leiomyosarcoma 10.7 KIT CD34
17 vagina leiomyoma 10.7 CD34 CALD1
18 colon leiomyosarcoma 10.7 KIT CD34
19 intravascular papillary endothelial hyperplasia 10.7 VEGFA SERPINA3
20 aortic malignant tumor 10.7 PECAM1 CD34
21 glomangiomyoma 10.7 CD34 CALD1
22 hemangioma of spleen 10.7 PECAM1 CD34
23 ovary sarcoma 10.7 PECAM1 CD34
24 nephrogenic adenofibroma 10.7 CD34 CALD1
25 uterine corpus sarcoma 10.7 KIT CALD1
26 fallopian tube leiomyoma 10.7 TSC2 CALD1
27 glomangioma 10.7 PECAM1 CD34 CALD1
28 fallopian tube benign neoplasm 10.7 TSC2 CALD1
29 angiolipoma 10.7 PECAM1 MLANA CD34
30 colonic lymphangioma 10.7 PECAM1 CD34
31 intravascular angioleiomyoma 10.7 PECAM1 CD34 CALD1
32 angiomyoma 10.7 PECAM1 CD34 CALD1
33 prostate angiosarcoma 10.7 VEGFA PECAM1 CD34
34 myxoid liposarcoma of the ovary 10.7 CD34 CALB2
35 myoma 10.7 KIT CD34 CALD1
36 liposarcoma of the ovary 10.7 CD34 CALB2
37 hemifacial spasm 10.7 VEGFA FLT4
38 vulvar leiomyoma 10.7 PECAM1 CD34 CALD1
39 cutaneous solitary mastocytoma 10.7 SERPINA3 KIT
40 skin sarcoma 10.7 PECAM1 CD34 CALD1
41 lung leiomyosarcoma 10.7 CD34 CALB2
42 esophagus sarcoma 10.6 KIT CD34
43 conventional angiosarcoma 10.6 PECAM1 CD34 CAMTA1
44 liposarcoma of bone 10.6 PECAM1 CD34
45 subungual glomus tumor 10.6 PECAM1 CD34 CALD1
46 glomeruloid hemangioma 10.6 VEGFA PECAM1 CD34
47 ovarian fibrothecoma 10.6 KIT CALB2
48 jejunal neoplasm 10.6 MLANA KIT CD34
49 malignant anus melanoma 10.6 MLANA KIT
50 malignant mesenchymoma 10.6 SERPINA3 CD34 CALD1

Graphical network of the top 20 diseases related to Cardiovascular Cancer:



Diseases related to Cardiovascular Cancer

Symptoms & Phenotypes for Cardiovascular Cancer

MGI Mouse Phenotypes related to Cardiovascular Cancer:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 CALB2 CAMTA1 KDR KIT MITF PDPN
2 growth/size/body region MP:0005378 10.35 CAMTA1 FLT4 KDR KIT MITF PDPN
3 cardiovascular system MP:0005385 10.32 FLT4 KDR KIT PDPN PECAM1 PTH1R
4 homeostasis/metabolism MP:0005376 10.32 CD34 FLT4 KDR KIT MITF PDPN
5 immune system MP:0005387 10.31 CD34 FLT4 KDR KIT MITF PDPN
6 hematopoietic system MP:0005397 10.3 CD34 KDR KIT MITF PDPN PECAM1
7 mortality/aging MP:0010768 10.25 CAMTA1 FLT4 KDR KIT MITF PDPN
8 integument MP:0010771 10.22 CD34 FLT4 KDR KIT MITF MLANA
9 embryo MP:0005380 10.2 FLT4 KDR KIT MITF PTH1R SETD2
10 craniofacial MP:0005382 10.17 KDR KIT MITF PTH1R SETD2 TFE3
11 digestive/alimentary MP:0005381 10.16 FLT4 KIT PDPN PECAM1 PTH1R TP53
12 liver/biliary system MP:0005370 10.16 FLT4 KDR KIT MITF PECAM1 PTH1R
13 muscle MP:0005369 10.01 FLT4 KDR KIT PDPN PECAM1 TP53
14 neoplasm MP:0002006 9.97 CAMTA1 CD34 KIT PTH1R SETD2 TP53
15 normal MP:0002873 9.96 CALB2 CAMTA1 FLT4 KDR KIT MITF
16 no phenotypic analysis MP:0003012 9.87 FLT4 KDR KIT MITF MLANA TP53
17 respiratory system MP:0005388 9.56 KDR KIT PDPN PECAM1 PTH1R TP53
18 pigmentation MP:0001186 9.55 KIT MITF MLANA TFE3 TP53
19 skeleton MP:0005390 9.36 KDR KIT MITF PDPN PECAM1 PTH1R

Drugs & Therapeutics for Cardiovascular Cancer

Drugs for Cardiovascular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Olive Phase 3
2 Sunflower Phase 3
3
leucovorin Approved 58-05-9 6006 143
4
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
5 Hematinics
6 Trace Elements
7 Vitamins
8 Micronutrients
9 Vitamin B Complex
10 Nutrients
11 Vitamin B9
12 Folate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 New Industrial Procedures for Achieving a Nutritional Added Value of the Olive Oil. The NUTRAOLEUM Study Unknown status NCT02520739 Phase 3
2 Non-inferiority Study of Telemedicine Versus Conventional CBT-I in Recently Hospitalized Patients With Insomnia Unknown status NCT03267537
3 McLean and Genomind Prospective Study of Pharmacogenetic Testing Recruiting NCT03113890

Search NIH Clinical Center for Cardiovascular Cancer

Genetic Tests for Cardiovascular Cancer

Anatomical Context for Cardiovascular Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Cancer:

19
Heart

MalaCards organs/tissues related to Cardiovascular Cancer:

40
Heart, Testes, Thymus, Neutrophil

Publications for Cardiovascular Cancer

Articles related to Cardiovascular Cancer:

(show top 50) (show all 127)
# Title Authors PMID Year
1
Educational inequalities in all-cause and cause-specific mortality among people with gout: a register-based matched cohort study in southern Sweden. 61
31660978 2019
2
Short- and long-term beneficial effects of medicinal mineral water administration. 61
31630285 2019
3
Prediction of cardiovascular, cancer and non-cardiovascular non-cancer death by exercise echocardiography. 61
31403879 2019
4
Inhibition of Human Serum Paraoxonase-I with Antimycotic Drugs: In Vitro and In Silico Studies. 61
31342307 2019
5
Correction: Impact of handgrip strength on cardiovascular, cancer and all-cause mortality in the Korean longitudinal study of ageing. 61
31189687 2019
6
Impact of handgrip strength on cardiovascular, cancer and all-cause mortality in the Korean longitudinal study of ageing. 61
31072857 2019
7
The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study. 61
30569368 2019
8
Association of Primary Care Physician Supply With Population Mortality in the United States, 2005-2015. 61
30776056 2019
9
Two theoretical strands of social capital, and total, cardiovascular, cancer and other mortality: A population-based prospective cohort study. 61
30623011 2019
10
Cardiovascular, cancer and mortality events after bariatric surgery in people with and without pre-existing diabetes: A nationwide study. 61
30191659 2019
11
Socioeconomic differences in healthy and disease-free life expectancy between ages 50 and 75: a multi-cohort study. 61
30307554 2019
12
Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses. 61
30957776 2019
13
Post-diagnosis smoking and risk of cardiovascular, cancer, and all-cause mortality in survivors of 10 adult cancers: a prospective cohort study. 61
31815049 2019
14
The Impact of Natural Antioxidants on the Regenerative Potential of Vascular Cells. 61
30968031 2019
15
LED-enhanced biosynthesis of biologically active ingredients in callus cultures of Ocimum basilicum. 61
30268421 2019
16
Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men. 61
29766437 2018
17
Association between psychological distress and mortality: the case of Israel. 61
29599386 2018
18
Subjective social status and mortality: the English Longitudinal Study of Ageing. 61
29779203 2018
19
Implications of plasma thiol redox in disease. 61
29967247 2018
20
Vitamin D and regulation of vascular cell function. 61
29351464 2018
21
Causes of Death after a Hospitalization with AKI. 61
29242248 2018
22
Total Physical Activity, Exercise Intensity, and Walking Speed as Predictors of All-Cause and Cause-Specific Mortality Over 7 Years in Older Men: The Concord Health and Aging in Men Project. 61
28993048 2018
23
Monoclonal Antibodies: A Review. 61
28799485 2018
24
Stress Echocardiography Positivity Predicts Cancer Death. 61
29233827 2017
25
Open Fluidics: A Cell Culture Flow System Developed Over Wettability Contrast-Based Chips. 61
29034587 2017
26
Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. 61
29024553 2017
27
Inflammatory potential of diet and risk of cardiovascular disease or mortality: A meta-analysis. 61
28744020 2017
28
Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer's dementia. 61
28199869 2017
29
MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease. 61
28253983 2017
30
Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity. 61
27316769 2017
31
Association of high-density lipoprotein cholesterol with non-fatal cardiac and non-cardiac events: a CANHEART substudy. 61
29344372 2017
32
Impact of Chronic Diseases and Multimorbidity on Health and Health Care Costs: The Additional Role of Musculoskeletal Disorders. 61
27111195 2016
33
Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. 61
27493134 2016
34
Life-Space Mobility and Mortality in Older Women: Prospective Results from the Study of Osteoporotic Fractures. 61
27696354 2016
35
Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: prospective cohort study. 61
27884868 2016
36
Long-term Cognitive Trajectories and Mortality in Older Women. 61
26843186 2016
37
The Simoa HD-1 Analyzer: A Novel Fully Automated Digital Immunoassay Analyzer with Single-Molecule Sensitivity and Multiplexing. 61
26077162 2016
38
[Effects of SIRT6 in cardiovascular, cancer and metabolic diseases]. 61
29888898 2016
39
Vitamin D - what is normal according to latest research and how should we deal with it? 61
27037388 2016
40
Life expectancy and causes of death after repair of intact and ruptured abdominal aortic aneurysms. 61
26553951 2016
41
CD4+/CD8+ ratio, age, and risk of serious noncommunicable diseases in HIV-infected adults on antiretroviral therapy. 61
26959354 2016
42
Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized controlled trial. 61
26864363 2016
43
Intrinsic and Extrinsic Cardiac Pseudotumors: Echocardiographic Evaluation and Review of the Literature. 61
26492868 2016
44
Vitamin D--what is normal according to latest research and how should we deal with it? 61
26634683 2015
45
[Research progress of trans-cinnamaldehyde pharmacological effects]. 61
27141665 2015
46
Death Rates among Detained Immigrants in the United States. 61
26569284 2015
47
Pulmonary Proteome and Protein Networks in Response to the Herbicide Paraquat in Rats. 61
26538867 2015
48
SurgiCal Obesity Treatment Study (SCOTS): protocol for a national prospective cohort study of patients undergoing bariatric surgery in Scotland. 61
26002692 2015
49
Epidemiology's continuing contribution to public health: The power of "Then and Now". 61
25810458 2015
50
Geographical distribution of alcohol-attributable mortality in Chile: a Bayesian spatial analysis. 61
25482366 2015

Variations for Cardiovascular Cancer

Expression for Cardiovascular Cancer

Search GEO for disease gene expression data for Cardiovascular Cancer.

Pathways for Cardiovascular Cancer

GO Terms for Cardiovascular Cancer

Cellular components related to Cardiovascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.8 WWTR1 VEGFA TSC2 TP53 PTH1R PECAM1
2 receptor complex GO:0043235 8.92 PTH1R KIT KDR FLT4

Biological processes related to Cardiovascular Cancer according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 VEGFA TP53 MITF KIT CD34
2 negative regulation of apoptotic process GO:0043066 9.91 VEGFA TP53 PDPN MITF KDR FLT4
3 positive regulation of protein phosphorylation GO:0001934 9.86 VEGFA PECAM1 KDR FLT4
4 positive regulation of cell proliferation GO:0008284 9.85 WWTR1 VEGFA PTH1R KIT KDR FLT4
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 VEGFA PECAM1 KIT
6 positive regulation of angiogenesis GO:0045766 9.78 VEGFA MIR143 KDR CD34
7 positive regulation of endothelial cell proliferation GO:0001938 9.77 VEGFA KDR FLT4
8 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.76 VEGFA KDR FLT4
9 regulation of cell shape GO:0008360 9.76 VEGFA PDPN KIT KDR
10 vasculogenesis GO:0001570 9.75 VEGFA SETD2 KDR
11 positive regulation of endothelial cell migration GO:0010595 9.74 VEGFA KDR FLT4
12 positive regulation of blood vessel endothelial cell migration GO:0043536 9.69 VEGFA MIR143 KDR
13 positive regulation of positive chemotaxis GO:0050927 9.63 VEGFA KDR
14 lymphangiogenesis GO:0001946 9.63 PDPN FLT4
15 positive regulation of vasculogenesis GO:2001214 9.62 KDR CD34
16 positive regulation of protein kinase C signaling GO:0090037 9.62 VEGFA FLT4
17 positive regulation of cellular component movement GO:0051272 9.61 VEGFA PDPN
18 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 VEGFA KDR FLT4
19 negative regulation of mitophagy GO:1901525 9.55 TSC2 TP53
20 positive regulation of cell migration GO:0030335 9.55 VEGFA PECAM1 PDPN KIT KDR
21 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.54 VEGFA TP53
22 endothelium development GO:0003158 9.52 KDR CD34
23 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.49 VEGFA KDR
24 sprouting angiogenesis GO:0002040 9.43 VEGFA KDR FLT4
25 angiogenesis GO:0001525 9.35 VEGFA SETD2 PECAM1 KDR FLT4
26 glomerular endothelium development GO:0072011 9.32 PECAM1 CD34
27 vascular endothelial growth factor signaling pathway GO:0038084 8.8 VEGFA KDR FLT4

Molecular functions related to Cardiovascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor binding GO:0038085 9.26 KDR FLT4
2 protein homodimerization activity GO:0042803 9.23 WWTR1 VEGFA TSC2 TP53 PTH1R PECAM1
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.16 KDR FLT4
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 KIT KDR FLT4

Sources for Cardiovascular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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