MCID: CRD118
MIFTS: 41

Cardiovascular Cancer

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Cardiovascular Cancer

MalaCards integrated aliases for Cardiovascular Cancer:

Name: Cardiovascular Cancer 12 54 15
Cardiovascular Neoplasm 12
Cardiovascular Tumors 12

Classifications:



External Ids:

Disease Ontology 12 DOID:176
NCIt 49 C4784
SNOMED-CT 67 721573003
UMLS 71 C0497243

Summaries for Cardiovascular Cancer

Disease Ontology : 12 An organ system cancer that located in the heart and blood vessels.

MalaCards based summary : Cardiovascular Cancer, also known as cardiovascular neoplasm, is related to heart cancer and vascular cancer. An important gene associated with Cardiovascular Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are PI3K-Akt signaling pathway and MAPK signaling pathway. The drugs Olive and Sunflower have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thymus, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Cardiovascular Cancer

Diseases related to Cardiovascular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 495)
# Related Disease Score Top Affiliating Genes
1 heart cancer 31.9 TSC2 SERPINA3 PECAM1 KRT7 KIT CD34
2 vascular cancer 30.0 WWTR1 VEGFA TSC2 TP53 TFE3 SYP
3 skin epithelioid hemangioma 10.7 PECAM1 CD34
4 aortic malignant tumor 10.7 PECAM1 CD34
5 penis sarcoma 10.7 MLANA CD34
6 central nervous system angiosarcoma 10.7 PECAM1 CD34
7 spinal cord sarcoma 10.7 KIT CD34
8 heart fibrosarcoma 10.7 PECAM1 CD34
9 ovarian angiosarcoma 10.7 PECAM1 CD34
10 gallbladder leiomyoma 10.7 KIT CD34
11 breast myofibroblastoma 10.7 CD34 CALD1
12 pulmonary vein leiomyosarcoma 10.7 CD34 CALD1
13 urethra leiomyoma 10.7 KIT CALD1
14 intravascular papillary endothelial hyperplasia 10.7 VEGFA SERPINA3
15 fallopian tube leiomyoma 10.7 TSC2 CALD1
16 small intestine leiomyosarcoma 10.7 KIT CD34
17 uterine corpus sarcoma 10.7 KIT CALD1
18 fallopian tube benign neoplasm 10.7 TSC2 CALD1
19 thyroid sarcoma 10.7 PECAM1 CD34
20 intravascular angioleiomyoma 10.7 PECAM1 CD34 CALD1
21 mucocele of appendix 10.7 KIT CD34
22 angiomyoma 10.7 PECAM1 CD34 CALD1
23 benign pleural mesothelioma 10.7 TP53 CD34
24 multifocal osteogenic sarcoma 10.7 TP53 CD34
25 conventional angiosarcoma 10.7 PECAM1 CD34 CAMTA1
26 prostate embryonal rhabdomyosarcoma 10.7 KIT CALD1
27 prostate angiosarcoma 10.7 VEGFA PECAM1 CD34
28 acquired hemangioma 10.7 PECAM1 PDPN
29 malignant mesenchymoma 10.7 SERPINA3 CD34 CALD1
30 central nervous system hemangioma 10.7 VEGFA PECAM1 CD34
31 gastric liposarcoma 10.7 KIT CD34
32 vulvar leiomyoma 10.7 PECAM1 CD34 CALD1
33 liposarcoma of bone 10.7 PECAM1 CD34
34 liver leiomyoma 10.7 PECAM1 KIT CD34
35 lung meningioma 10.7 SYP CD34
36 hemifacial spasm 10.7 VEGFA FLT4
37 central nervous system fibrosarcoma 10.7 KRT7 CD34
38 hemangioma of spleen 10.7 PECAM1 CD34
39 heart sarcoma 10.7 PECAM1 KIT CD34
40 malignant anus melanoma 10.7 MLANA KIT
41 ovarian fibrothecoma 10.7 KIT CALB2
42 myofibroma 10.7 SERPINA3 CD34 CALD1
43 deep leiomyoma 10.7 KIT CD34 CALD1
44 bacillary angiomatosis 10.7 VEGFA PECAM1 CD34
45 acinar cell cystadenocarcinoma 10.7 SYP SERPINA3
46 clear cell cystadenofibroma 10.7 TP53 CALB2
47 lung combined type small cell carcinoma 10.7 SYP CALD1
48 cutaneous solitary mastocytoma 10.7 SERPINA3 KIT
49 colon leiomyosarcoma 10.7 KIT CD34 CALD1
50 retroperitoneal leiomyosarcoma 10.7 KIT CD34 CALD1

Graphical network of the top 20 diseases related to Cardiovascular Cancer:



Diseases related to Cardiovascular Cancer

Symptoms & Phenotypes for Cardiovascular Cancer

MGI Mouse Phenotypes related to Cardiovascular Cancer:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 CALB2 CAMTA1 KDR KIT PDPN SERPINA3
2 homeostasis/metabolism MP:0005376 10.27 CD34 FLT4 KDR KIT KRT7 PDPN
3 hematopoietic system MP:0005397 10.22 CD34 CD68 KDR KIT PDPN PECAM1
4 immune system MP:0005387 10.21 CD34 CD68 FLT4 KDR KIT PDPN
5 cardiovascular system MP:0005385 10.19 FLT4 KDR KIT PDPN PECAM1 SETD2
6 integument MP:0010771 10.14 CD34 FLT4 KDR KIT MLANA PDPN
7 liver/biliary system MP:0005370 9.97 FLT4 KDR KIT PECAM1 TP53 TSC2
8 muscle MP:0005369 9.92 FLT4 KDR KIT PDPN PECAM1 TP53
9 neoplasm MP:0002006 9.8 CAMTA1 CD34 KIT SETD2 TP53 TSC2
10 no phenotypic analysis MP:0003012 9.7 CD68 FLT4 KDR KIT MLANA TP53
11 normal MP:0002873 9.65 CALB2 CAMTA1 FLT4 KDR KIT SYP
12 skeleton MP:0005390 9.32 CD68 KDR KIT PDPN PECAM1 SETD2

Drugs & Therapeutics for Cardiovascular Cancer

Drugs for Cardiovascular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Olive Phase 3
2 Sunflower Phase 3
3
leucovorin Approved 58-05-9 6006 143
4
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
5 Vitamin B Complex
6 Folate
7 Vitamin B9

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 New Industrial Procedures for Achieving a Nutritional Added Value of the Olive Oil. The NUTRAOLEUM Study Unknown status NCT02520739 Phase 3
2 Non-inferiority Study of Telemedicine Versus Conventional CBT-I in Recently Hospitalized Patients With Insomnia Unknown status NCT03267537
3 McLean and Genomind Prospective Study of Pharmacogenetic Testing Recruiting NCT03113890
4 The Effectiveness of Nintendo Wii Fit and Inspiratory Muscle Training in Older Patients With Heart Failure Recruiting NCT04254328

Search NIH Clinical Center for Cardiovascular Cancer

Genetic Tests for Cardiovascular Cancer

Anatomical Context for Cardiovascular Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Cancer:

19
Heart

MalaCards organs/tissues related to Cardiovascular Cancer:

40
Heart, Testes, Thymus, Liver, Neutrophil

Publications for Cardiovascular Cancer

Articles related to Cardiovascular Cancer:

(show top 50) (show all 135)
# Title Authors PMID Year
1
Coronary Flow Velocity Reserve Reduction Is Associated with Cardiovascular, Cancer, and Noncancer, Noncardiovascular Mortality. 61
32173203 2020
2
Use of benzodiazepines non-compliant with guidelines in patients with psychiatric and non-psychiatric chronic disorders. 61
32408031 2020
3
Migraine, headache, and mortality in women: a cohort study. 61
32183686 2020
4
Short- and long-term beneficial effects of medicinal mineral water administration. 61
31630285 2020
5
The Dose-Response Associations of Sedentary Time with Chronic Diseases and the Risk for All-Cause Mortality Affected by Different Health Status: A Systematic Review and Meta-Analysis. 61
31886810 2020
6
Intracellular Chloride Channels: Novel Biomarkers in Diseases. 61
32116799 2020
7
Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK. 61
32470091 2020
8
Sex differences in the association between marital status and the risk of cardiovascular, cancer, and all-cause mortality: a systematic review and meta-analysis of 7,881,040 individuals. 61
32161813 2020
9
Epidemiology of non-alcoholic and alcoholic fatty liver diseases. 61
32258520 2020
10
Inhibition of Human Serum Paraoxonase-I with Antimycotic Drugs: In Vitro and In Silico Studies. 61
31342307 2020
11
Educational inequalities in all-cause and cause-specific mortality among people with gout: a register-based matched cohort study in southern Sweden. 61
31660978 2019
12
Prediction of cardiovascular, cancer and non-cardiovascular non-cancer death by exercise echocardiography. 61
31403879 2019
13
Correction: Impact of handgrip strength on cardiovascular, cancer and all-cause mortality in the Korean longitudinal study of ageing. 61
31189687 2019
14
Impact of handgrip strength on cardiovascular, cancer and all-cause mortality in the Korean longitudinal study of ageing. 61
31072857 2019
15
The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study. 61
30569368 2019
16
Association of Primary Care Physician Supply With Population Mortality in the United States, 2005-2015. 61
30776056 2019
17
Two theoretical strands of social capital, and total, cardiovascular, cancer and other mortality: A population-based prospective cohort study. 61
30623011 2019
18
Cardiovascular, cancer and mortality events after bariatric surgery in people with and without pre-existing diabetes: A nationwide study. 61
30191659 2019
19
Socioeconomic differences in healthy and disease-free life expectancy between ages 50 and 75: a multi-cohort study. 61
30307554 2019
20
Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses. 61
30957776 2019
21
The Impact of Natural Antioxidants on the Regenerative Potential of Vascular Cells. 61
30968031 2019
22
LED-enhanced biosynthesis of biologically active ingredients in callus cultures of Ocimum basilicum. 61
30268421 2019
23
Post-diagnosis smoking and risk of cardiovascular, cancer, and all-cause mortality in survivors of 10 adult cancers: a prospective cohort study. 61
31815049 2019
24
Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men. 61
29766437 2018
25
Subjective social status and mortality: the English Longitudinal Study of Ageing. 61
29779203 2018
26
Association between psychological distress and mortality: the case of Israel. 61
29599386 2018
27
Implications of plasma thiol redox in disease. 61
29967247 2018
28
Vitamin D and regulation of vascular cell function. 61
29351464 2018
29
Causes of Death after a Hospitalization with AKI. 61
29242248 2018
30
Total Physical Activity, Exercise Intensity, and Walking Speed as Predictors of All-Cause and Cause-Specific Mortality Over 7 Years in Older Men: The Concord Health and Aging in Men Project. 61
28993048 2018
31
Monoclonal Antibodies: A Review. 61
28799485 2018
32
Open Fluidics: A Cell Culture Flow System Developed Over Wettability Contrast-Based Chips. 61
29034587 2017
33
Stress Echocardiography Positivity Predicts Cancer Death. 61
29233827 2017
34
Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. 61
29024553 2017
35
Inflammatory potential of diet and risk of cardiovascular disease or mortality: A meta-analysis. 61
28744020 2017
36
Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer's dementia. 61
28199869 2017
37
Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity. 61
27316769 2017
38
MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease. 61
28253983 2017
39
Association of high-density lipoprotein cholesterol with non-fatal cardiac and non-cardiac events: a CANHEART substudy. 61
29344372 2017
40
Impact of Chronic Diseases and Multimorbidity on Health and Health Care Costs: The Additional Role of Musculoskeletal Disorders. 61
27111195 2016
41
Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: prospective cohort study. 61
27884868 2016
42
Life-Space Mobility and Mortality in Older Women: Prospective Results from the Study of Osteoporotic Fractures. 61
27696354 2016
43
Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. 61
27493134 2016
44
Long-term Cognitive Trajectories and Mortality in Older Women. 61
26843186 2016
45
[Effects of SIRT6 in cardiovascular, cancer and metabolic diseases]. 61
29888898 2016
46
The Simoa HD-1 Analyzer: A Novel Fully Automated Digital Immunoassay Analyzer with Single-Molecule Sensitivity and Multiplexing. 61
26077162 2016
47
Vitamin D - what is normal according to latest research and how should we deal with it? 61
27037388 2016
48
Life expectancy and causes of death after repair of intact and ruptured abdominal aortic aneurysms. 61
26553951 2016
49
Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized controlled trial. 61
26864363 2016
50
CD4+/CD8+ ratio, age, and risk of serious noncommunicable diseases in HIV-infected adults on antiretroviral therapy. 61
26959354 2016

Variations for Cardiovascular Cancer

Expression for Cardiovascular Cancer

Search GEO for disease gene expression data for Cardiovascular Cancer.

Pathways for Cardiovascular Cancer

GO Terms for Cardiovascular Cancer

Cellular components related to Cardiovascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 WWTR1 VEGFA TSC2 TP53 TFE3 PECAM1

Biological processes related to Cardiovascular Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.85 VEGFA PECAM1 KDR FLT4
2 positive regulation of kinase activity GO:0033674 9.77 KIT KDR FLT4
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 VEGFA PECAM1 KIT
4 positive regulation of endothelial cell proliferation GO:0001938 9.76 VEGFA KDR FLT4
5 regulation of cell shape GO:0008360 9.76 VEGFA PDPN KIT KDR
6 vasculogenesis GO:0001570 9.75 VEGFA SETD2 KDR
7 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.74 VEGFA KDR FLT4
8 positive regulation of endothelial cell migration GO:0010595 9.73 VEGFA KDR FLT4
9 angiogenesis GO:0001525 9.72 VEGFA SETD2 PECAM1 KDR FLT4
10 positive regulation of cell migration GO:0030335 9.65 VEGFA PECAM1 PDPN KIT KDR
11 positive regulation of vasculogenesis GO:2001214 9.63 KDR CD34
12 positive regulation of positive chemotaxis GO:0050927 9.62 VEGFA KDR
13 lymphangiogenesis GO:0001946 9.62 PDPN FLT4
14 positive regulation of protein kinase C signaling GO:0090037 9.61 VEGFA FLT4
15 positive regulation of cellular component movement GO:0051272 9.61 VEGFA PDPN
16 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 VEGFA KDR FLT4
17 negative regulation of mitophagy GO:1901525 9.54 TSC2 TP53
18 sprouting angiogenesis GO:0002040 9.54 VEGFA KDR FLT4
19 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.52 VEGFA TP53
20 endothelium development GO:0003158 9.51 KDR CD34
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.49 VEGFA KDR
22 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.48 VEGFA KDR
23 hematopoietic progenitor cell differentiation GO:0002244 9.46 TP53 KIT KDR FLT4
24 glomerular endothelium development GO:0072011 9.43 PECAM1 CD34
25 vascular endothelial growth factor signaling pathway GO:0038084 9.13 VEGFA KDR FLT4
26 vascular wound healing GO:0061042 8.8 VEGFA KDR CD34

Molecular functions related to Cardiovascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 KIT KDR FLT4
2 vascular endothelial growth factor binding GO:0038085 9.32 KDR FLT4
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.26 KDR FLT4
4 growth factor binding GO:0019838 9.13 KIT KDR FLT4
5 protein homodimerization activity GO:0042803 9.1 WWTR1 VEGFA TSC2 PECAM1 KIT FLT4

Sources for Cardiovascular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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