Cardiovascular Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060091

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Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary : Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Pathways in cancer and ErbB signaling pathway. Affiliated tissues include heart, liver and skin, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)

#	Related Disease	Score	Top Affiliating Genes
1	hemangioma	30.7	CD34 KDR PECAM1 PROX1 RET SLC2A1
2	pericardium leiomyoma	11.2
3	cerebrovascular benign neoplasm	11.2
4	hemangioendothelioma	10.3	KDR PECAM1
5	intravascular papillary endothelial hyperplasia	10.3	SERPINA3 VEGFA
6	hemangioblastoma	10.3	SLC2A1 VEGFA VHL
7	arteriovenous malformation	10.3	ACVRL1 RASA1 VEGFA
8	neural crest tumor	10.3	SDHB SDHC SDHD
9	extra-adrenal pheochromocytoma	10.3	SDHB SDHC SDHD
10	persistent generalized lymphadenopathy	10.3	SDHB SDHC SDHD
11	chondroma	10.3	SDHB SDHC SDHD
12	paraganglioma and gastric stromal sarcoma	10.3	SDHB SDHC SDHD
13	carney triad	10.3	SDHB SDHC SDHD
14	plethora of newborn	10.3	SDHB SDHC SDHD
15	retinal hemangioblastoma	10.3	SERPINA3 VEGFA VHL
16	lymph node disease	10.3	SDHB SDHC SDHD
17	mitochondrial complex ii deficiency	10.3	SDHB SDHC SDHD
18	lymphatic system disease	10.3	SDHB SDHC SDHD
19	radiation proctitis	10.2	KDR PECAM1 VEGFA
20	hydrocele	10.2	AFP PECAM1 VEGFA
21	renal pelvis adenocarcinoma	10.2	AFP SLC2A1
22	pediatric angiosarcoma	10.2	CD34 VEGFA
23	lymphangioma	10.1	KDR PROX1 VEGFA
24	telangiectasis	10.1	ACVRL1 AFP VEGFA
25	paragangliomas 1	10.1	RET SDHB SDHC SDHD
26	adrenal medulla cancer	10.1	RET SDHB SDHC SDHD
27	glomeruloid hemangioma	10.1	CD34 VEGFA
28	urachal adenocarcinoma	10.1	AFP NF1
29	peliosis hepatis	10.1	AFP MEN1 VEGFA
30	renal cell carcinoma, papillary, 1	10.1	ELOC SDHB VHL
31	angiokeratoma circumscriptum	10.1	KDR RASA1 SLC2A1 VEGFA
32	multiple endocrine neoplasia, type i	10.1	MEN1 RET SDHB SDHD
33	ovarian germ cell cancer	10.0	AFP RET
34	angiosarcoma	10.0	KDR PECAM1 PROX1 VEGFA
35	arteriovenous malformations of the brain	10.0	ACVRL1 KDR RASA1 VEGFA
36	hemangioma of liver	10.0	CD34 VHL
37	kidney cancer	10.0	KDR VEGFA VHL
38	supratentorial cancer	10.0	KDR NF1 VEGFA
39	cerebrum cancer	10.0	KDR NF1 VEGFA
40	lymphangiosarcoma	10.0	CD34 PROX1 VEGFA
41	clear cell renal cell carcinoma	10.0	KDR SLC2A1 VEGFA VHL
42	ovarian solid teratoma	10.0	AFP CD34
43	pancreatic serous cystadenoma	10.0	VEGFA VHL VHLL
44	connective tissue cancer	10.0	CD34 SERPINA3 VEGFA
45	malignant pineal area germ cell neoplasm	10.0	AFP CD34
46	hereditary paraganglioma-pheochromocytoma syndromes	10.0	RET SDHB SDHC SDHD VHL
47	hyperparathyroidism 2 with jaw tumors	10.0	MEN1 RET
48	sternum cancer	10.0	AFP CD34
49	placental insufficiency	10.0	AFP KDR VEGFA
50	congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	10.0	ACVRL1 NF1 PECAM1 RASA1 SLC2A1

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:

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Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁷ (show all 32)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	10.79	ACVRL1 KDR NF1 RET SDHD VHL
2	Decreased viability	GR00221-A-2	10.79	ACVRL1 KDR NF1 RET SDHD VHL
3	Decreased viability	GR00221-A-3	10.79	ACVRL1 KDR RASA1
4	Decreased viability	GR00221-A-4	10.79	ACVRL1 KDR NF1 RET SDHD RASA1
5	Decreased viability	GR00231-A	10.79	RET
6	Decreased viability	GR00301-A	10.79	RET VHL
7	Decreased viability	GR00381-A-1	10.79	SDHD RASA1
8	Decreased viability	GR00402-S-2	10.79	ACVRL1 KDR NF1 RET SDHD VHL
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	10.12	RASA1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	10.12	ACVRL1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	10.12	MEN1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	10.12	MEN1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	10.12	MEN1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	10.12	ACVRL1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-132	10.12	SDHC
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	10.12	ACVRL1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	10.12	MEN1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-188	10.12	SDHC SDHD
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-197	10.12	SDHC
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	10.12	ACVRL1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	10.12	RASA1
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	10.12	ACVRL1 MEN1
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	10.12	MEN1
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	10.12	MEN1
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	10.12	RASA1
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.12	ACVRL1 SDHC
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.12	ACVRL1
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	10.12	ACVRL1 MEN1 RASA1 SDHC SDHD
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.12	ACVRL1
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.12	RASA1
31	shRNA abundance <= 50%	GR00343-S	9.32	ACVRL1 KDR MEN1 NF1 PROX1 RET
32	Decreased sensitivity to paclitaxel	GR00112-A-0	9.26	NF1 VHL

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

⁴⁷ (show all 18)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.38	CD34 GLA KDR MEN1 NF1 PECAM1
2	homeostasis/metabolism	MP:0005376	10.38	ACVRL1 AFP CD34 GLA KDR MEN1
3	cardiovascular system	MP:0005385	10.35	ACVRL1 GLA KDR MEN1 NF1 PECAM1
4	growth/size/body region	MP:0005378	10.29	ACVRL1 GLA KDR MEN1 NF1 PROX1
5	mortality/aging	MP:0010768	10.28	ACVRL1 AFP GLA KDR MEN1 NF1
6	hematopoietic system	MP:0005397	10.27	ACVRL1 CD34 KDR NF1 PECAM1 PROX1
7	embryo	MP:0005380	10.24	ACVRL1 KDR MEN1 NF1 RASA1 RET
8	digestive/alimentary	MP:0005381	10.2	ACVRL1 MEN1 NF1 PECAM1 PROX1 RASA1
9	immune system	MP:0005387	10.2	CD34 GLA KDR MEN1 NF1 PECAM1
10	endocrine/exocrine gland	MP:0005379	10.18	AFP MEN1 NF1 PROX1 RET SDHB
11	liver/biliary system	MP:0005370	10.13	ACVRL1 AFP GLA KDR MEN1 NF1
12	muscle	MP:0005369	10.11	ACVRL1 GLA KDR MEN1 NF1 PECAM1
13	craniofacial	MP:0005382	10.1	ACVRL1 KDR MEN1 NF1 RASA1 VEGFA
14	nervous system	MP:0003631	10	ACVRL1 GLA KDR MEN1 NF1 PROX1
15	neoplasm	MP:0002006	9.97	AFP CD34 MEN1 NF1 RET SDHB
16	normal	MP:0002873	9.81	ACVRL1 KDR NF1 PROX1 RET SDHB
17	renal/urinary system	MP:0005367	9.56	ACVRL1 GLA NF1 PECAM1 RET SDHB
18	respiratory system	MP:0005388	9.17	ACVRL1 KDR NF1 PECAM1 PROX1 RET

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Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

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Genetic Tests for Cardiovascular Organ Benign Neoplasm

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Anatomical Context for Cardiovascular Organ Benign Neoplasm

MalaCards organs/tissues related to Cardiovascular Organ Benign Neoplasm:

⁴²

Heart, Liver, Skin, Brain, Kidney, Lymph Node, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Organ Benign Neoplasm:

²⁰

The Blood

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Publications for Cardiovascular Organ Benign Neoplasm

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Genes for Cardiovascular Organ Benign Neoplasm

Genes related to Cardiovascular Organ Benign Neoplasm (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	17.59	DISEASES inferred ¹⁵
2	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	17.19	DISEASES inferred ¹⁵
3	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	16.72	DISEASES inferred ¹⁵
4	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	16.66	DISEASES inferred ¹⁵
5	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	16.65	DISEASES inferred ¹⁵
6	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	16.52	DISEASES inferred ¹⁵
7	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	16.48	DISEASES inferred ¹⁵
8	RASA1	RAS P21 Protein Activator 1	Protein Coding	16.27	DISEASES inferred ¹⁵
9	GLA	Galactosidase Alpha	Protein Coding	16.27	DISEASES inferred ¹⁵
10	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	16.08	DISEASES inferred ¹⁵
11	PROX1	Prospero Homeobox 1	Protein Coding	16.03	DISEASES inferred ¹⁵
12	SERPINA3	Serpin Family A Member 3	Protein Coding	16.01	DISEASES inferred ¹⁵ ¹⁵
13	MEN1	Menin 1	Protein Coding	15.97	DISEASES inferred ¹⁵
14	RET	Ret Proto-Oncogene	Protein Coding	15.94	DISEASES inferred ¹⁵
15	NF1	Neurofibromin 1	Protein Coding	15.94	DISEASES inferred ¹⁵
16	KDR	Kinase Insert Domain Receptor	Protein Coding	15.94	DISEASES inferred ¹⁵
17	AFP	Alpha Fetoprotein	Protein Coding	15.83	DISEASES inferred ¹⁵
18	CD34	CD34 Molecule	Protein Coding	7.19	DISEASES inferred ¹⁵
19	VHLL	VHL Like	Protein Coding	5.95	DISEASES inferred ¹⁵
20	ELOC	Elongin C	Protein Coding	5.87	DISEASES inferred ¹⁵

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Variations for Cardiovascular Organ Benign Neoplasm

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Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

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Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁸	12.56	ELOC RET SLC2A1 VEGFA VHL
2	ErbB signaling pathway ¹ ³⁸ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶² EGFR tyrosine kinase inhibitor resistance ³⁸ Renal cell carcinoma ³⁸ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.33	ELOC SLC2A1 VEGFA VHL
3	Development VEGF signaling via VEGFR2 - generic cascades ²³ Show member pathways Development VEGF signaling and activation ²³ VEGF - VEGF R2 Signaling Pathways ⁶⁶	12.09	KDR NF1 RASA1 VEGFA
4	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.75	AFP KDR PROX1 VEGFA
5	Citrate cycle (TCA cycle) ³⁸ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.7	SDHB SDHC SDHD
6	Angiogenesis (CST) ⁴	11.58	KDR PECAM1 PROX1
7	HIF-1 signaling pathway ³⁸	11.56	ELOC SLC2A1 VEGFA VHL
8	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.42	KDR RASA1 VEGFA VHL
9	Aryl Hydrocarbon Receptor ¹	11.23	NF1 RET VEGFA
10	HIF1Alpha Pathway ⁶⁵	10.99	ELOC SLC2A1 VEGFA VHL
11	Amplification and Expansion of Oncogenic Pathways as Metastatic Traits ¹	10.75	VEGFA VHL
12	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ¹	10.67	ELOC VHL
13	HIF-2-alpha transcription factor network ¹	10.55	ELOC KDR SLC2A1 VEGFA VHL

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GO Terms for Cardiovascular Organ Benign Neoplasm

Cellular components related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:0045121	9.56	KDR PECAM1 RET SLC2A1
2	VCB complex	GO:0030891	9.16	VHL VHLL
3	respiratory chain complex II	GO:0045273	8.96	SDHB SDHC
4	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.8	SDHB SDHC SDHD

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.95	ACVRL1 MEN1 NF1 PROX1 VHL
2	negative regulation of apoptotic process	GO:0043066	9.91	KDR RASA1 VEGFA VHL
3	angiogenesis	GO:0001525	9.88	ACVRL1 KDR PECAM1 VEGFA
4	MAPK cascade	GO:0000165	9.86	MEN1 NF1 RASA1 RET
5	response to hypoxia	GO:0001666	9.76	ACVRL1 NF1 SLC2A1 VEGFA
6	vasculogenesis	GO:0001570	9.71	KDR RASA1 VEGFA
7	positive regulation of angiogenesis	GO:0045766	9.67	ACVRL1 CD34 KDR VEGFA
8	negative regulation of nitric oxide biosynthetic process	GO:0045019	9.62	CD34 GLA
9	vascular endothelial growth factor signaling pathway	GO:0038084	9.61	KDR VEGFA
10	positive regulation of endothelial cell migration	GO:0010595	9.61	KDR PROX1 VEGFA
11	lymphangiogenesis	GO:0001946	9.6	ACVRL1 PROX1
12	positive regulation of positive chemotaxis	GO:0050927	9.59	KDR VEGFA
13	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001241	9.58	NF1 RET
14	positive regulation of vasculogenesis	GO:2001214	9.57	CD34 KDR
15	endothelium development	GO:0003158	9.52	CD34 KDR
16	lymphatic endothelial cell differentiation	GO:0060836	9.51	ACVRL1 PROX1
17	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.49	SDHC SDHD
18	regulation of blood vessel endothelial cell migration	GO:0043535	9.48	ACVRL1 NF1
19	tricarboxylic acid cycle	GO:0006099	9.43	SDHB SDHC SDHD
20	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	GO:0038033	9.4	KDR VEGFA
21	negative regulation of gene expression	GO:0010629	9.35	ACVRL1 CD34 KDR VEGFA VHL
22	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061418	9.33	ELOC VEGFA VHL
23	glomerular endothelium development	GO:0072011	9.32	CD34 PECAM1
24	positive regulation of endothelial cell proliferation	GO:0001938	9.02	ACVRL1 KDR NF1 PROX1 VEGFA

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transfer activity	GO:0009055	9.43	SDHB SDHC SDHD
2	ubiquinone binding	GO:0048039	8.96	SDHB SDHD
3	succinate dehydrogenase (ubiquinone) activity	GO:0008177	8.8	SDHB SDHC SDHD
4	protein binding	GO:0005515	10.09	ACVRL1 AFP ELOC GLA KDR MEN1

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