Cardiovascular Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm ¹¹ ¹⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060091

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Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology: ¹¹ An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary: Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is ACVRL1 (Activin A Receptor Like Type 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. Affiliated tissues include blood and heart, and related phenotypes are Increased sensitivity to paclitaxel and normal

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Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 419)

#	Related Disease	Score	Top Affiliating Genes
1	hemangioma	32.5	VHL VEGFA PECAM1 ENG CTNNB1 CD34
2	pericardium leiomyoma	11.3
3	cerebrovascular benign neoplasm	11.3
4	angiomyoma	10.6	PECAM1 CD34
5	skin epithelioid hemangioma	10.5	PECAM1 CD34
6	aorta angiosarcoma	10.5	PECAM1 CD34
7	central nervous system angiosarcoma	10.5	PECAM1 CD34
8	intravascular angioleiomyoma	10.5	PECAM1 CD34
9	weber syndrome	10.5	RASA1 ENG ACVRL1
10	prostate angiosarcoma	10.5	VEGFA PECAM1 CD34
11	glomangiomyoma	10.5	PECAM1 MIR143 CD34
12	perivascular tumor	10.5	SERPINA3 PECAM1 CD34
13	glomeruloid hemangioma	10.5	VEGFA PECAM1 CD34
14	heart fibrosarcoma	10.5	PECAM1 CD34
15	benign perivascular tumor	10.5	PECAM1 MIR143 CD34
16	thyroid angiosarcoma	10.5	PECAM1 CD34
17	cystadenocarcinoma	10.5	VEGFA SERPINA3 NF1
18	sarcomatoid squamous cell skin carcinoma	10.5	SERPINA3 PECAM1 CD34
19	heart sarcoma	10.5	SERPINA3 PECAM1 CD34
20	acquired hemangioma	10.5	VEGFA PECAM1 CD34
21	bacillary angiomatosis	10.5	VEGFA PECAM1 CD34
22	glomangioma	10.5	PECAM1 CD34
23	lymphangiosarcoma	10.5	VEGFA PECAM1 CD34
24	glomangiomatosis	10.5	PECAM1 CD34
25	heart cancer	10.5	SERPINA3 PECAM1 CD34
26	conventional angiosarcoma	10.5	PECAM1 CD34
27	fumarate hydratase deficiency	10.5	VHL ACVRL1
28	telangiectasia, hereditary hemorrhagic, type 1	10.5	RASA1 ENG ACVRL1
29	bartonellosis	10.5	VEGFA PECAM1 CD34
30	pyogenic granuloma	10.5	VEGFA PECAM1 CD34
31	retinal hemangioblastoma	10.5	VHL VEGFA SERPINA3
32	childhood angiosarcoma	10.5	VEGFA PECAM1 CD34
33	hemangiopericytoma, malignant	10.5	SERPINA3 PECAM1 CD34
34	intermittent proptosis	10.5	PECAM1 NF1
35	gallbladder leiomyosarcoma	10.5	PECAM1 CD34
36	angiodysplasia	10.5	VEGFA ENG ACVRL1
37	venous hemangioma	10.5	PECAM1 CD34
38	ovarian angiosarcoma	10.5	PECAM1 CD34
39	kidney hemangiopericytoma	10.5	PECAM1 CD34
40	sweat gland disease	10.5	SERPINA3 GLA CD34
41	intussusception	10.5	VEGFA PECAM1 CD34
42	epiglottis cancer	10.5	ENG CD34
43	epithelioid neurofibroma	10.5	NF1 CD34
44	capillary disease	10.5	VEGFA PECAM1 CD34
45	malignant spindle cell melanoma	10.5	SERPINA3 NF1 CD34
46	ossifying fibroma	10.5	SERPINA3 NF1 CD34
47	malignant epithelioid hemangioendothelioma	10.5	SERPINA3 PECAM1
48	glomangiosarcoma	10.5	PECAM1 CD34
49	breast hemangioma	10.5	PECAM1 CD34
50	thyroid sarcoma	10.5	PECAM1 CD34

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:

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Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased sensitivity to paclitaxel	GR00112-A-0	8.62	SMAD4 VHL

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal	MP:0002873	10.13	ACVRL1 CCR6 CTNNB1 ENG MIR18A NF1
2	muscle	MP:0005369	10.13	ACVRL1 CTNNB1 ENG GLA NF1 PECAM1
3	renal/urinary system	MP:0005367	10.11	ACVRL1 CTNNB1 ENG GLA NF1 PECAM1
4	liver/biliary system	MP:0005370	10.01	ACVRL1 CTNNB1 GLA NF1 PECAM1 SMAD4
5	cardiovascular system	MP:0005385	10	ACVRL1 CCR6 CTNNB1 ENG GDF2 GLA
6	digestive/alimentary	MP:0005381	9.97	ACVRL1 CTNNB1 ENG NF1 PECAM1 RASA1
7	limbs/digits/tail	MP:0005371	9.91	CTNNB1 ENG NF1 RASA1 SMAD4 VEGFA
8	craniofacial	MP:0005382	9.86	ACVRL1 CTNNB1 ENG NF1 RASA1 SMAD4
9	immune system	MP:0005387	9.77	CCR6 CD34 CTNNB1 ENG GDF2 GLA
10	hematopoietic system	MP:0005397	9.44	ACVRL1 CCR6 CD34 CTNNB1 ENG GDF2

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Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials, NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

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Genetic Tests for Cardiovascular Organ Benign Neoplasm

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Anatomical Context for Cardiovascular Organ Benign Neoplasm

Organs/tissues related to Cardiovascular Organ Benign Neoplasm:

FMA: Blood

MalaCards : Heart

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Publications for Cardiovascular Organ Benign Neoplasm

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Genes for Cardiovascular Organ Benign Neoplasm

Genes related to Cardiovascular Organ Benign Neoplasm (0 elite genes):

(show top 50) (show all 55)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	8.61	DISEASES inferred ¹⁴
2	SERPINA3	Serpin Family A Member 3	Protein Coding	8.3	DISEASES inferred ¹⁴ ¹⁴
3	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	8.18	DISEASES inferred ¹⁴
4	MIR143	MicroRNA 143	RNA Gene	8.1	DISEASES inferred ¹⁴ ¹⁴
5	GLA	Galactosidase Alpha	Protein Coding	7.96	DISEASES inferred ¹⁴
6	CD34	CD34 Molecule	Protein Coding	7.92	DISEASES inferred ¹⁴
7	MIR18A	MicroRNA 18a	RNA Gene	7.92	DISEASES inferred ¹⁴ ¹⁴
8	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	7.84	DISEASES inferred ¹⁴
9	ENG	Endoglin	Protein Coding	7.69	DISEASES inferred ¹⁴
10	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	7.66	DISEASES inferred ¹⁴
11	RASA1	RAS P21 Protein Activator 1	Protein Coding	7.66	DISEASES inferred ¹⁴
12	MIR195	MicroRNA 195	RNA Gene	7.56	DISEASES inferred ¹⁴ ¹⁴
13	H2AC18	H2A Clustered Histone 18	Protein Coding	7.52	DISEASES inferred ¹⁴ ¹⁴
14	MIR17	MicroRNA 17	RNA Gene	7.49	DISEASES inferred ¹⁴ ¹⁴
15	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.39	DISEASES inferred ¹⁴ ¹⁴
16	NF1	Neurofibromin 1	Protein Coding	7.37	DISEASES inferred ¹⁴
17	SYNGAP1	Synaptic Ras GTPase Activating Protein 1	Protein Coding	7.33	DISEASES inferred ¹⁴
18	GDF2	Growth Differentiation Factor 2	Protein Coding	7.27	DISEASES inferred ¹⁴
19	CTNNB1	Catenin Beta 1	Protein Coding	7.19	DISEASES inferred ¹⁴
20	SMAD4	SMAD Family Member 4	Protein Coding	7.15	DISEASES inferred ¹⁴
21	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	7.1	DISEASES inferred ¹⁴
22	TP53	Tumor Protein P53	Protein Coding	7.09	DISEASES inferred ¹⁴
23	MIR15A	MicroRNA 15a	RNA Gene	7.08	DISEASES inferred ¹⁴ ¹⁴
24	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	7.04	DISEASES inferred ¹⁴
25	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	6.99	DISEASES inferred ¹⁴
26	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	6.95	DISEASES inferred ¹⁴
27	AFP	Alpha Fetoprotein	Protein Coding	6.93	DISEASES inferred ¹⁴
28	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	6.92	DISEASES inferred ¹⁴
29	MIR199A1	MicroRNA 199a-1	RNA Gene	6.9	DISEASES inferred ¹⁴ ¹⁴
30	MIR200C	MicroRNA 200c	RNA Gene	6.9	DISEASES inferred ¹⁴ ¹⁴
31	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	6.87	DISEASES inferred ¹⁴
32	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	6.87	DISEASES inferred ¹⁴
33	MEN1	Menin 1	Protein Coding	6.86	DISEASES inferred ¹⁴
34	KDR	Kinase Insert Domain Receptor	Protein Coding	6.83	DISEASES inferred ¹⁴
35	SYP	Synaptophysin	Protein Coding	6.82	DISEASES inferred ¹⁴
36	MIR200A	MicroRNA 200a	RNA Gene	6.8	DISEASES inferred ¹⁴ ¹⁴
37	TMEM127	Transmembrane Protein 127	Protein Coding	6.78	DISEASES inferred ¹⁴
38	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6.76	DISEASES inferred ¹⁴
39	EPHB4	EPH Receptor B4	Protein Coding	6.76	DISEASES inferred ¹⁴
40	CAMTA1	Calmodulin Binding Transcription Activator 1	Protein Coding	6.74	DISEASES inferred ¹⁴
41	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	6.74	DISEASES inferred ¹⁴
42	ELOC	Elongin C	Protein Coding	6.69	DISEASES inferred ¹⁴
43	PDPN	Podoplanin	Protein Coding	6.66	DISEASES inferred ¹⁴
44	ELOB	Elongin B	Protein Coding	6.66	DISEASES inferred ¹⁴
45	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	6.66	DISEASES inferred ¹⁴
46	CHGA	Chromogranin A	Protein Coding	6.61	DISEASES inferred ¹⁴
47	FGF2	Fibroblast Growth Factor 2	Protein Coding	6.61	DISEASES inferred ¹⁴
48	CUL2	Cullin 2	Protein Coding	6.6	DISEASES inferred ¹⁴
49	ENO2	Enolase 2	Protein Coding	6.58	DISEASES inferred ¹⁴
50	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6.58	DISEASES inferred ¹⁴

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Variations for Cardiovascular Organ Benign Neoplasm

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Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

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Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.49	ACVRL1 CCR6 CTNNB1 GDF2 NF1 RASA1
2	Signal Transduction ⁶⁶	13.41	VHL VEGFA SYNGAP1 SMAD4 RASA1 NF1
3	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.2	VEGFA RASA1 NF1 CTNNB1
4	Integrated breast cancer pathway ⁷⁴	11.88	VEGFA SMAD4 NF1 CTNNB1
5	TGF-beta Signaling Pathways ⁶⁵	11.68	SMAD4 ENG ACVRL1
6	Head and neck squamous cell carcinoma ⁷⁴	11.53	VEGFA SMAD4 CTNNB1
7	Signaling by BMP ⁶⁶ Show member pathways BMP receptor signaling ⁶¹ BMP Signalling Pathway ⁶¹	11.47	SMAD4 GDF2 ACVRL1
8	HIF-1-alpha transcription factor network ⁶¹	11.45	VEGFA SMAD4 ENG
9	NRP1-triggered signaling pathways in pancreatic cancer ⁷⁴	11.33	VEGFA SMAD4 PECAM1
10	miRNAs involved in DNA damage response ⁷⁴	11.28	MIR195 MIR18A MIR17 MIR143
11	Regulation of Ras family activation ⁶¹ Show member pathways Activation of RAS in B cells ⁶⁶	11.05	SYNGAP1 RASA1 NF1
12	Heart development ⁷⁴	10.93	VEGFA SMAD4 MIR143 CTNNB1
13	ALK1 signaling events ⁶¹ Show member pathways ALK1 pathway ⁶¹	10.32	SMAD4 GDF2 ENG ACVRL1

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GO Terms for Cardiovascular Organ Benign Neoplasm

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	10.33	VEGFA MIR17 GDF2 ENG CTNNB1 CD34
2	negative regulation of cell population proliferation	GO:0008285	10.31	VHL SMAD4 NF1 MIR195 CTNNB1 ACVRL1
3	angiogenesis	GO:0001525	10.27	VEGFA NF1 GDF2 ENG ACVRL1
4	osteoblast differentiation	GO:0001649	10.17	CTNNB1 GDF2 NF1 SMAD4
5	BMP signaling pathway	GO:0030509	10.17	ACVRL1 ENG GDF2 SMAD4
6	negative regulation of angiogenesis	GO:0016525	10.13	NF1 MIR143 GDF2 CTNNB1
7	response to hypoxia	GO:0001666	10.13	VEGFA SMAD4 NF1 ENG ACVRL1
8	positive regulation of endothelial cell proliferation	GO:0001938	10.1	VEGFA NF1 GDF2 ACVRL1
9	cellular response to BMP stimulus	GO:0071773	10.08	ACVRL1 GDF2 SMAD4
10	epithelial to mesenchymal transition	GO:0001837	10.04	SMAD4 ENG CTNNB1
11	artery morphogenesis	GO:0048844	10.03	ENG NF1 VEGFA
12	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862	10.01	SMAD4 GDF2 ENG ACVRL1
13	activin receptor signaling pathway	GO:0032924	9.99	ACVRL1 GDF2 SMAD4
14	negative regulation of Ras protein signal transduction	GO:0046580	9.97	SYNGAP1 RASA1 NF1
15	positive regulation of BMP signaling pathway	GO:0030513	9.97	SMAD4 GDF2 ENG ACVRL1
16	negative regulation of gene expression	GO:0010629	9.97	ACVRL1 CD34 CTNNB1 ENG MIR17 VEGFA
17	blood vessel morphogenesis	GO:0048514	9.95	RASA1 GDF2 ACVRL1
18	regulation of blood vessel endothelial cell migration	GO:0043535	9.93	NF1 ACVRL1
19	positive regulation of endothelial cell differentiation	GO:0045603	9.91	ACVRL1 CTNNB1 GDF2
20	glomerular endothelium development	GO:0072011	9.9	PECAM1 CD34
21	central nervous system vasculogenesis	GO:0022009	9.89	ENG CTNNB1
22	negative regulation of endothelial cell proliferation	GO:0001937	9.87	ACVRL1 ENG GDF2 NF1
23	branching involved in blood vessel morphogenesis	GO:0001569	9.86	VEGFA GDF2 ENG CTNNB1
24	positive regulation of cardiac muscle cell apoptotic process	GO:0010666	9.76	SMAD4 MIR195 MIR17
25	positive regulation of angiogenesis	GO:0045766	9.7	VEGFA MIR143 GDF2 ENG CD34 ACVRL1
26	positive regulation of pulmonary blood vessel remodeling	GO:1905111	9.54	MIR17 MIR143
27	endocardial cushion to mesenchymal transition	GO:0090500	9.52	ENG ACVRL1
28	vasculogenesis	GO:0001570	9.28	VEGFA RASA1 GDF2 ENG CTNNB1

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA base-pairing translational repressor activity	GO:1903231	9.26	MIR195 MIR18A MIR17 MIR143
2	sulfate binding	GO:0043199	8.92	SMAD4 CD34

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Sources for Cardiovascular Organ Benign Neoplasm

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CRD007 MIFTS: 28	Cardiovascular Organ Benign Neoplasm Categories: Cancer diseases, Cardiovascular diseases	Data Licensing For inquiries, contact: [email protected]
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