Cardiovascular Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060091

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Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary : Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is ACVRL1 (Activin A Receptor Like Type 1), and among its related pathways/superpathways are Pathways in cancer and MAPK signaling pathway. Affiliated tissues include heart and blood, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)

#	Related Disease	Score	Top Affiliating Genes
1	hemangioma	30.6	VHL VEGFA SLC2A1 PROX1 PECAM1 KDR
2	pericardium leiomyoma	11.4
3	cerebrovascular benign neoplasm	11.4
4	pulmonary arteriovenous malformation	10.7	ENG ACVRL1
5	angiodysplasia	10.6	VEGFA ENG ACVRL1
6	weber syndrome	10.6	RASA1 ENG ACVRL1
7	telangiectasis	10.6	VEGFA ENG ACVRL1
8	juvenile nasopharyngeal angiofibroma	10.6	VEGFA PECAM1 ENG
9	neural crest tumor	10.6	SDHD SDHB
10	intravascular papillary endothelial hyperplasia	10.5	VEGFA SERPINA3
11	radiation proctitis	10.5	VEGFA PECAM1 KDR
12	hemangioblastoma	10.5	VHL VEGFA SLC2A1
13	drug-induced lupus erythematosus	10.5	VEGFA KDR ENG
14	hemifacial spasm	10.5	VEGFA FLT4
15	retinal hemangioblastoma	10.5	VHL VEGFA SERPINA3
16	hereditary paraganglioma-pheochromocytoma syndromes	10.5	VHL SDHD SDHB
17	arteriovenous malformation	10.4	VEGFA RASA1 ENG ACVRL1
18	extra-adrenal pheochromocytoma	10.4	SDHD SDHB
19	hydrocele	10.4	VEGFA PECAM1 FLT4
20	hemangioendothelioma	10.4	PECAM1 KDR FLT4
21	pediatric angiosarcoma	10.4	VEGFA CD34
22	gorham's disease	10.4	GLMN FLT4
23	pancreatic serous cystadenoma	10.4	VHL VEGFA
24	lymphatic malformations	10.4	PROX1 FLT4
25	angiokeratoma circumscriptum	10.3	VEGFA SLC2A1 RASA1 KDR
26	kidney cancer	10.3	VHL VEGFA KDR
27	klippel-trenaunay-weber syndrome	10.3	RASA1 GLMN FLT4
28	glomeruloid hemangioma	10.3	VEGFA ENG CD34
29	lymphatic system disease	10.3	SDHD SDHB FLT4
30	hemangioma of liver	10.2	VHL CD34
31	multiple endocrine neoplasia	10.2	VHL SDHB NF1
32	bone squamous cell carcinoma	10.2	KDR ENG
33	arteriovenous malformations of the brain	10.2	VEGFA RASA1 KDR ENG ACVRL1
34	multiple endocrine neoplasia, type iia	10.2	SDHD SDHB NF1
35	cerebrum cancer	10.2	VEGFA NF1 KDR
36	supratentorial cancer	10.2	VEGFA NF1 KDR
37	venous malformations, multiple cutaneous and mucosal	10.2	RASA1 GLMN FLT4 ACVRL1
38	hobnail hemangioma	10.2	FLT4 CD34
39	benign perivascular tumor	10.2	SLC2A1 GLMN CD34
40	connective tissue cancer	10.1	VEGFA SERPINA3 CD34
41	sporadic pheochromocytoma	10.1	VHL SDHD SDHB NF1
42	pheochromocytoma	10.1	VHL SDHD SDHB NF1
43	deep angioma	10.1	SLC2A1 CD34
44	paraganglioma	10.1	VHL SDHD SDHB NF1
45	lymphangioma	10.1	VEGFA PROX1 KDR FLT4
46	autosomal genetic disease	10.1	VEGFA SDHD SDHB NF1
47	malignant epithelioid hemangioendothelioma	10.1	KDR FLT4 CD34
48	gastrointestinal system cancer	10.0	VEGFA KDR CD34
49	malignant hemangioma	10.0	KDR FLT4 CD34
50	interstitial emphysema	10.0	PROX1 FLT4 CD34

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:

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Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	10.19	ACVRL1 KDR NF1 SDHD VHL
2	Decreased viability	GR00221-A-2	10.19	ACVRL1 KDR NF1 SDHD VHL FLT4
3	Decreased viability	GR00221-A-3	10.19	ACVRL1 KDR RASA1
4	Decreased viability	GR00221-A-4	10.19	ACVRL1 KDR NF1 SDHD RASA1
5	Decreased viability	GR00301-A	10.19	VHL
6	Decreased viability	GR00342-S-1	10.19	FLT4
7	Decreased viability	GR00342-S-2	10.19	FLT4
8	Decreased viability	GR00342-S-3	10.19	FLT4
9	Decreased viability	GR00381-A-1	10.19	SDHD RASA1
10	Decreased viability	GR00402-S-2	10.19	ACVRL1 KDR NF1 SDHD VHL RASA1
11	Decreased sensitivity to paclitaxel	GR00112-A-0	8.96	NF1 VHL

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

⁴⁶ (show all 18)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.41	ACVRL1 CD2AP ENG FLT4 GLA GLMN
2	homeostasis/metabolism	MP:0005376	10.38	ACVRL1 CD2AP CD34 ENG FLT4 GLA
3	cellular	MP:0005384	10.37	ARHGAP32 CD34 GLA GLMN KDR NF1
4	growth/size/body region	MP:0005378	10.36	ACVRL1 CD2AP ENG FLT4 GLA GLMN
5	mortality/aging	MP:0010768	10.28	ACVRL1 CD2AP ENG FLT4 GLA GLMN
6	behavior/neurological	MP:0005386	10.27	ACVRL1 ARHGAP32 ENG GLA KDR NF1
7	hematopoietic system	MP:0005397	10.27	ACVRL1 CD2AP CD34 ENG KDR NF1
8	embryo	MP:0005380	10.26	ACVRL1 ENG FLT4 GLMN KDR NF1
9	immune system	MP:0005387	10.2	CD2AP CD34 FLT4 GLA KDR NF1
10	digestive/alimentary	MP:0005381	10.19	ACVRL1 ENG FLT4 NF1 PECAM1 PROX1
11	muscle	MP:0005369	10.11	ACVRL1 ENG FLT4 GLA KDR NF1
12	craniofacial	MP:0005382	10.09	ACVRL1 ENG KDR NF1 RASA1 VEGFA
13	liver/biliary system	MP:0005370	10.09	ACVRL1 FLT4 GLA KDR NF1 PECAM1
14	nervous system	MP:0003631	10.03	ACVRL1 ARHGAP32 ENG GLA GLMN KDR
15	normal	MP:0002873	9.85	ACVRL1 ENG FLT4 KDR NF1 PROX1
16	neoplasm	MP:0002006	9.8	CD34 NF1 SDHB SDHD VEGFA VHL
17	renal/urinary system	MP:0005367	9.56	ACVRL1 CD2AP GLA NF1 PECAM1 SDHB
18	respiratory system	MP:0005388	9.17	ACVRL1 ENG KDR NF1 PECAM1 PROX1

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Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

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Genetic Tests for Cardiovascular Organ Benign Neoplasm

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Anatomical Context for Cardiovascular Organ Benign Neoplasm

MalaCards organs/tissues related to Cardiovascular Organ Benign Neoplasm:

⁴¹

Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Organ Benign Neoplasm:

¹⁹

Blood

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Publications for Cardiovascular Organ Benign Neoplasm

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Genes for Cardiovascular Organ Benign Neoplasm

Genes related to Cardiovascular Organ Benign Neoplasm (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	18.61	DISEASES inferred ¹⁵
2	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	17.74	DISEASES inferred ¹⁵
3	ENG	Endoglin	Protein Coding	17.61	DISEASES inferred ¹⁵
4	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	17.42	DISEASES inferred ¹⁵
5	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	17.08	DISEASES inferred ¹⁵
6	RASA1	RAS P21 Protein Activator 1	Protein Coding	17.08	DISEASES inferred ¹⁵
7	GLA	Galactosidase Alpha	Protein Coding	16.93	DISEASES inferred ¹⁵
8	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	16.75	DISEASES inferred ¹⁵
9	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	16.39	DISEASES inferred ¹⁵
10	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	16.37	DISEASES inferred ¹⁵
11	KDR	Kinase Insert Domain Receptor	Protein Coding	16.31	DISEASES inferred ¹⁵
12	GLMN	Glomulin, FKBP Associated Protein	Protein Coding	16.24	DISEASES inferred ¹⁵
13	SERPINA3	Serpin Family A Member 3	Protein Coding	16.11	DISEASES inferred ¹⁵ ¹⁵
14	PROX1	Prospero Homeobox 1	Protein Coding	16.08	DISEASES inferred ¹⁵
15	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	16.08	DISEASES inferred ¹⁵
16	FLT4	Fms Related Tyrosine Kinase 4	Protein Coding	15.97	DISEASES inferred ¹⁵
17	CD2AP	CD2 Associated Protein	Protein Coding	15.88	DISEASES inferred ¹⁵
18	NF1	Neurofibromin 1	Protein Coding	15.84	DISEASES inferred ¹⁵
19	CD34	CD34 Molecule	Protein Coding	7.21	DISEASES inferred ¹⁵
20	ELOB	Elongin B	Protein Coding	5.94	DISEASES inferred ¹⁵
21	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	5.83	DISEASES inferred ¹⁵
22	PDPN	Podoplanin	Protein Coding	5.81	DISEASES inferred ¹⁵

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Variations for Cardiovascular Organ Benign Neoplasm

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Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

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Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁷	12.62	VHL VEGFA SLC2A1 FLT4 ELOB
2	MAPK signaling pathway ³⁷ ¹	12.52	VEGFA RASA1 NF1 KDR FLT4
3	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.45	VEGFA RASA1 NF1 KDR FLT4
4	ErbB signaling pathway ³⁷ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ EGFR tyrosine kinase inhibitor resistance ³⁷ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.37	VHL VEGFA SLC2A1 ELOB
5	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.17	VEGFA RASA1 NF1 KDR
6	EPHA forward signaling ¹ Show member pathways EPHA-mediated growth cone collapse ⁶⁶ Ephrin A reverse signaling ¹ EphrinA-EPHA pathway ¹ EphrinA-EphR Signaling ⁶⁴	11.78	VEGFA RASA1 KDR
7	HIF-1 signaling pathway ³⁷	11.66	VHL VEGFA SLC2A1 ELOB
8	Angiogenesis (CST) ⁴	11.5	PROX1 PECAM1 KDR FLT4 ENG
9	HIF-1-alpha transcription factor network ¹	11.42	VEGFA SLC2A1 ENG
10	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.4	VHL VEGFA RASA1 KDR FLT4 CD2AP
11	HIF1Alpha Pathway ⁶⁴	11.29	VHL VEGFA SLC2A1 ELOB
12	Vemurafenib Pathway, Pharmacodynamics ⁶¹	11.18	VEGFA KDR FLT4
13	Amplification and Expansion of Oncogenic Pathways as Metastatic Traits ¹	10.77	VHL VEGFA
14	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ¹	10.7	VHL ELOB
15	HIF-2-alpha transcription factor network ¹	10.55	VHL VEGFA SLC2A1 KDR ELOB

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GO Terms for Cardiovascular Organ Benign Neoplasm

Cellular components related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor complex	GO:0043235	9.46	KDR FLT4 ENG ACVRL1
2	Cul2-RING ubiquitin ligase complex	GO:0031462	9.32	GLMN ELOB
3	VCB complex	GO:0030891	8.96	VHL ELOB
4	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.62	SDHD SDHB
5	cytoplasm	GO:0005737	10.1	VHL VEGFA SLC2A1 RASA1 PROX1 PECAM1

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 33)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein phosphorylation	GO:0001934	9.91	VEGFA KDR FLT4 ENG
2	response to hypoxia	GO:0001666	9.87	VEGFA SLC2A1 NF1 ACVRL1
3	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.79	VEGFA KDR FLT4
4	positive regulation of angiogenesis	GO:0045766	9.77	VEGFA KDR ENG CD34 ACVRL1
5	negative regulation of gene expression	GO:0010629	9.73	VHL VEGFA KDR ENG CD34 ACVRL1
6	cellular response to vascular endothelial growth factor stimulus	GO:0035924	9.7	VEGFA KDR FLT4
7	sprouting angiogenesis	GO:0002040	9.69	VEGFA FLT4 ENG
8	blood vessel morphogenesis	GO:0048514	9.67	RASA1 FLT4 ACVRL1
9	negative regulation of nitric oxide biosynthetic process	GO:0045019	9.66	GLA CD34
10	endocardial cushion morphogenesis	GO:0003203	9.65	ENG ACVRL1
11	positive regulation of positive chemotaxis	GO:0050927	9.65	VEGFA KDR
12	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061418	9.65	VHL VEGFA ELOB
13	lymph vessel development	GO:0001945	9.64	PROX1 FLT4
14	smooth muscle tissue development	GO:0048745	9.64	NF1 ENG
15	positive regulation of vasculogenesis	GO:2001214	9.63	KDR CD34
16	positive regulation of protein kinase C signaling	GO:0090037	9.63	VEGFA FLT4
17	artery morphogenesis	GO:0048844	9.63	VEGFA NF1 ENG
18	angiogenesis	GO:0001525	9.63	VEGFA PECAM1 KDR FLT4 ENG ACVRL1
19	dorsal aorta morphogenesis	GO:0035912	9.62	ENG ACVRL1
20	positive regulation of endothelial cell migration	GO:0010595	9.62	VEGFA PROX1 KDR FLT4
21	venous blood vessel morphogenesis	GO:0048845	9.61	PROX1 ENG
22	vascular endothelial growth factor signaling pathway	GO:0038084	9.61	VEGFA KDR FLT4
23	regulation of blood vessel endothelial cell migration	GO:0043535	9.6	NF1 ACVRL1
24	lymphatic endothelial cell differentiation	GO:0060836	9.59	PROX1 ACVRL1
25	endothelium development	GO:0003158	9.58	KDR CD34
26	atrial cardiac muscle tissue morphogenesis	GO:0055009	9.58	PROX1 ENG
27	lymphangiogenesis	GO:0001946	9.58	PROX1 FLT4 ACVRL1
28	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	GO:0038033	9.56	VEGFA KDR
29	glomerular endothelium development	GO:0072011	9.55	PECAM1 CD34
30	endocardial cushion to mesenchymal transition	GO:0090500	9.54	ENG ACVRL1
31	vasculogenesis	GO:0001570	9.35	VEGFA RASA1 KDR GLMN ENG
32	positive regulation of endothelial cell proliferation	GO:0001938	9.1	VEGFA PROX1 NF1 KDR FLT4 ACVRL1
33	negative regulation of apoptotic process	GO:0043066	10.05	VHL VEGFA RASA1 KDR FLT4

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.58	VHL VEGFA SLC2A1 SERPINA3 SDHB RASA1
2	activin binding	GO:0048185	9.4	ENG ACVRL1
3	ubiquinone binding	GO:0048039	9.37	SDHD SDHB
4	growth factor binding	GO:0019838	9.33	KDR FLT4 ACVRL1
5	vascular endothelial growth factor-activated receptor activity	GO:0005021	9.32	KDR FLT4
6	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.26	SDHD SDHB
7	vascular endothelial growth factor receptor binding	GO:0005172	8.96	VEGFA CD2AP

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