MCID: CRD007
MIFTS: 27

Cardiovascular Organ Benign Neoplasm

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060091

Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary : Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Development VEGF signaling via VEGFR2 - generic cascades. Affiliated tissues include blood and heart, and related phenotypes are Decreased sensitivity to paclitaxel and cardiovascular system

Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 369)
# Related Disease Score Top Affiliating Genes
1 hemangioma 32.8 VHL VEGFA TP53 PECAM1 ENG CTNNB1
2 pericardium leiomyoma 11.4
3 cerebrovascular benign neoplasm 11.4
4 skin epithelioid hemangioma 10.8 PECAM1 CD34
5 aortic malignant tumor 10.8 PECAM1 CD34
6 central nervous system angiosarcoma 10.8 PECAM1 CD34
7 intravascular angioleiomyoma 10.8 PECAM1 CD34
8 sarcomatoid squamous cell skin carcinoma 10.8 SERPINA3 PECAM1 CD34
9 prostate angiosarcoma 10.8 VEGFA PECAM1 CD34
10 central nervous system hemangioma 10.8 VEGFA PECAM1 CD34
11 intravascular papillary endothelial hyperplasia 10.8 VEGFA SERPINA3
12 heart fibrosarcoma 10.8 PECAM1 CD34
13 ovarian angiosarcoma 10.8 PECAM1 CD34
14 cystic lymphangioma 10.8 SERPINA3 PECAM1 CD34
15 retroperitoneal hemangiopericytoma 10.8 VEGFA PECAM1 CD34
16 pulmonary arteriovenous malformation 10.8 ENG ACVRL1
17 breast angiosarcoma 10.8 VEGFA PECAM1 CD34
18 myofibroma 10.8 SERPINA3 MIR143 CD34
19 heart cancer 10.8 SERPINA3 PECAM1 CD34
20 bacillary angiomatosis 10.8 VEGFA PECAM1 CD34
21 lymphangiosarcoma 10.7 VEGFA PECAM1 CD34
22 retinal hemangioblastoma 10.7 VHL VEGFA SERPINA3
23 mechanical ectropion 10.7 NF1 CD34
24 capillary lymphangioma 10.7 PECAM1 ENG CD34
25 conventional angiosarcoma 10.7 PECAM1 CD34
26 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.7 PECAM1 ENG ACVRL1
27 cystadenocarcinoma 10.7 VEGFA TP53 SERPINA3
28 juvenile nasopharyngeal angiofibroma 10.7 VEGFA PECAM1 ENG
29 intravascular fasciitis 10.7 PECAM1 CTNNB1 CD34
30 adamantinous craniopharyngioma 10.7 VEGFA SERPINA3 CTNNB1
31 hemangiopericytoma, malignant 10.7 SERPINA3 PECAM1 CD34
32 angiodysplasia 10.7 VEGFA ENG ACVRL1
33 breast hemangioma 10.7 TP53 PECAM1 CD34
34 breast malignant phyllodes tumor 10.7 TP53 SERPINA3 CD34
35 angiomyoma 10.7 PECAM1 CD34
36 smooth muscle tumor 10.7 SERPINA3 MIR143 CD34
37 malignant spindle cell melanoma 10.7 SERPINA3 NF1 CD34
38 subungual glomus tumor 10.7 PECAM1 NF1 CD34
39 weber syndrome 10.7 RASA1 ENG ACVRL1
40 adult xanthogranuloma 10.7 SERPINA3 NF1 CD34
41 intussusception 10.7 VEGFA PECAM1 CD34
42 spindle cell sarcoma 10.7 VEGFA SERPINA3 CD34
43 angiokeratoma of fordyce 10.7 PECAM1 NF1 GLA
44 sebaceous gland disease 10.7 SERPINA3 MIR132 CCR6
45 mast cell neoplasm 10.7 SERPINA3 H2AC18 CD34
46 breast sarcoma 10.7 TP53 PECAM1 CD34
47 glomangiomatosis 10.7 TP53 PECAM1 CD34
48 gallbladder leiomyosarcoma 10.7 PECAM1 CD34
49 trachoma 10.7 VEGFA SERPINA3 ENG
50 glomangiosarcoma 10.7 PECAM1 CD34

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:



Diseases related to Cardiovascular Organ Benign Neoplasm

Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.32 NF1

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 ACVRL1 CCR6 CTNNB1 ENG GLA NF1
2 homeostasis/metabolism MP:0005376 10.18 ACVRL1 CCR6 CD34 CTNNB1 ENG GLA
3 hematopoietic system MP:0005397 10.14 ACVRL1 CCR6 CD34 CTNNB1 ENG NF1
4 digestive/alimentary MP:0005381 10.11 ACVRL1 CTNNB1 ENG NF1 PECAM1 RASA1
5 embryo MP:0005380 10.09 ACVRL1 CTNNB1 ENG NF1 RASA1 SDHD
6 craniofacial MP:0005382 10.08 ACVRL1 CTNNB1 ENG NF1 RASA1 TP53
7 muscle MP:0005369 9.96 ACVRL1 CTNNB1 ENG GLA NF1 PECAM1
8 liver/biliary system MP:0005370 9.92 ACVRL1 CTNNB1 GLA NF1 PECAM1 TP53
9 neoplasm MP:0002006 9.7 CD34 CTNNB1 NF1 SDHD TP53 VEGFA
10 normal MP:0002873 9.61 ACVRL1 CCR6 CTNNB1 ENG NF1 SDHD
11 renal/urinary system MP:0005367 9.23 ACVRL1 CTNNB1 GLA NF1 PECAM1 TP53

Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

Genetic Tests for Cardiovascular Organ Benign Neoplasm

Anatomical Context for Cardiovascular Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Organ Benign Neoplasm:

19
Blood

MalaCards organs/tissues related to Cardiovascular Organ Benign Neoplasm:

40
Heart

Publications for Cardiovascular Organ Benign Neoplasm

Variations for Cardiovascular Organ Benign Neoplasm

Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 VHL VEGFA TP53 SERPINA3 RASA1 PECAM1
2
Show member pathways
12.06 VEGFA RASA1 NF1 CTNNB1
3 11.85 VEGFA TP53 MIR195 MIR15A MIR143
4 11.75 VEGFA TP53 NF1 CTNNB1
5 11.6 VEGFA TP53 PECAM1 CTNNB1
6 11.23 VHL VEGFA TP53
7
Show member pathways
10.89 VHL VEGFA RASA1 CTNNB1

GO Terms for Cardiovascular Organ Benign Neoplasm

Cellular components related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.8 PECAM1 CTNNB1 CD34

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.93 TP53 NF1 MIR195 MIR15A CTNNB1
2 angiogenesis GO:0001525 9.92 VEGFA PECAM1 ENG ACVRL1
3 in utero embryonic development GO:0001701 9.91 VEGFA TP53 CTNNB1 ACVRL1
4 positive regulation of gene expression GO:0010628 9.91 VEGFA TP53 MIR132 ENG CTNNB1 CD34
5 negative regulation of angiogenesis GO:0016525 9.81 NF1 MIR15A MIR143 CTNNB1
6 heart development GO:0007507 9.8 TP53 NF1 ENG CTNNB1 ACVRL1
7 positive regulation of endothelial cell proliferation GO:0001938 9.78 VEGFA NF1 ACVRL1
8 positive regulation of neuron apoptotic process GO:0043525 9.74 TP53 NF1 CTNNB1
9 negative regulation of cell proliferation GO:0008285 9.7 VHL TP53 NF1 MIR195 MIR15A CTNNB1
10 branching involved in blood vessel morphogenesis GO:0001569 9.63 VEGFA ENG CTNNB1
11 endothelial tube morphogenesis GO:0061154 9.6 CTNNB1 ACVRL1
12 vascular wound healing GO:0061042 9.59 VEGFA CD34
13 dorsal aorta morphogenesis GO:0035912 9.58 ENG ACVRL1
14 negative regulation of neuroblast proliferation GO:0007406 9.58 TP53 NF1
15 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.56 VEGFA TP53
16 vasculogenesis GO:0001570 9.56 VEGFA RASA1 ENG CTNNB1
17 regulation of blood vessel endothelial cell migration GO:0043535 9.55 NF1 ACVRL1
18 artery morphogenesis GO:0048844 9.54 VEGFA NF1 ENG
19 central nervous system vasculogenesis GO:0022009 9.52 ENG CTNNB1
20 negative regulation of nitric oxide biosynthetic process GO:0045019 9.5 MIR132 GLA CD34
21 endocardial cushion to mesenchymal transition GO:0090500 9.49 ENG ACVRL1
22 glomerular endothelium development GO:0072011 9.48 PECAM1 CD34
23 positive regulation of angiogenesis GO:0045766 9.43 VEGFA MIR143 MIR132 ENG CD34 ACVRL1
24 negative regulation of gene expression GO:0010629 9.23 VHL VEGFA TP53 MIR132 ENG CTNNB1

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta-activated receptor activity GO:0005024 8.62 ENG ACVRL1

Sources for Cardiovascular Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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