Cardiovascular Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRD007 MIFTS: 27	Cardiovascular Organ Benign Neoplasm Categories: Cancer diseases, Cardiovascular diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060091

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Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary : Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Development VEGF signaling via VEGFR2 - generic cascades. Affiliated tissues include blood and heart, and related phenotypes are Decreased sensitivity to paclitaxel and cardiovascular system

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Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 369)

#	Related Disease	Score	Top Affiliating Genes
1	hemangioma	32.8	VHL VEGFA TP53 PECAM1 ENG CTNNB1
2	pericardium leiomyoma	11.4
3	cerebrovascular benign neoplasm	11.4
4	skin epithelioid hemangioma	10.8	PECAM1 CD34
5	aortic malignant tumor	10.8	PECAM1 CD34
6	central nervous system angiosarcoma	10.8	PECAM1 CD34
7	intravascular angioleiomyoma	10.8	PECAM1 CD34
8	sarcomatoid squamous cell skin carcinoma	10.8	SERPINA3 PECAM1 CD34
9	prostate angiosarcoma	10.8	VEGFA PECAM1 CD34
10	central nervous system hemangioma	10.8	VEGFA PECAM1 CD34
11	intravascular papillary endothelial hyperplasia	10.8	VEGFA SERPINA3
12	heart fibrosarcoma	10.8	PECAM1 CD34
13	ovarian angiosarcoma	10.8	PECAM1 CD34
14	cystic lymphangioma	10.8	SERPINA3 PECAM1 CD34
15	retroperitoneal hemangiopericytoma	10.8	VEGFA PECAM1 CD34
16	pulmonary arteriovenous malformation	10.8	ENG ACVRL1
17	breast angiosarcoma	10.8	VEGFA PECAM1 CD34
18	myofibroma	10.8	SERPINA3 MIR143 CD34
19	heart cancer	10.8	SERPINA3 PECAM1 CD34
20	bacillary angiomatosis	10.8	VEGFA PECAM1 CD34
21	lymphangiosarcoma	10.7	VEGFA PECAM1 CD34
22	retinal hemangioblastoma	10.7	VHL VEGFA SERPINA3
23	mechanical ectropion	10.7	NF1 CD34
24	capillary lymphangioma	10.7	PECAM1 ENG CD34
25	conventional angiosarcoma	10.7	PECAM1 CD34
26	congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	10.7	PECAM1 ENG ACVRL1
27	cystadenocarcinoma	10.7	VEGFA TP53 SERPINA3
28	juvenile nasopharyngeal angiofibroma	10.7	VEGFA PECAM1 ENG
29	intravascular fasciitis	10.7	PECAM1 CTNNB1 CD34
30	adamantinous craniopharyngioma	10.7	VEGFA SERPINA3 CTNNB1
31	hemangiopericytoma, malignant	10.7	SERPINA3 PECAM1 CD34
32	angiodysplasia	10.7	VEGFA ENG ACVRL1
33	breast hemangioma	10.7	TP53 PECAM1 CD34
34	breast malignant phyllodes tumor	10.7	TP53 SERPINA3 CD34
35	angiomyoma	10.7	PECAM1 CD34
36	smooth muscle tumor	10.7	SERPINA3 MIR143 CD34
37	malignant spindle cell melanoma	10.7	SERPINA3 NF1 CD34
38	subungual glomus tumor	10.7	PECAM1 NF1 CD34
39	weber syndrome	10.7	RASA1 ENG ACVRL1
40	adult xanthogranuloma	10.7	SERPINA3 NF1 CD34
41	intussusception	10.7	VEGFA PECAM1 CD34
42	spindle cell sarcoma	10.7	VEGFA SERPINA3 CD34
43	angiokeratoma of fordyce	10.7	PECAM1 NF1 GLA
44	sebaceous gland disease	10.7	SERPINA3 MIR132 CCR6
45	mast cell neoplasm	10.7	SERPINA3 H2AC18 CD34
46	breast sarcoma	10.7	TP53 PECAM1 CD34
47	glomangiomatosis	10.7	TP53 PECAM1 CD34
48	gallbladder leiomyosarcoma	10.7	PECAM1 CD34
49	trachoma	10.7	VEGFA SERPINA3 ENG
50	glomangiosarcoma	10.7	PECAM1 CD34

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:

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Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased sensitivity to paclitaxel	GR00112-A-0	8.32	NF1

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

⁴⁵ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.27	ACVRL1 CCR6 CTNNB1 ENG GLA NF1
2	homeostasis/metabolism	MP:0005376	10.18	ACVRL1 CCR6 CD34 CTNNB1 ENG GLA
3	hematopoietic system	MP:0005397	10.14	ACVRL1 CCR6 CD34 CTNNB1 ENG NF1
4	digestive/alimentary	MP:0005381	10.11	ACVRL1 CTNNB1 ENG NF1 PECAM1 RASA1
5	embryo	MP:0005380	10.09	ACVRL1 CTNNB1 ENG NF1 RASA1 SDHD
6	craniofacial	MP:0005382	10.08	ACVRL1 CTNNB1 ENG NF1 RASA1 TP53
7	muscle	MP:0005369	9.96	ACVRL1 CTNNB1 ENG GLA NF1 PECAM1
8	liver/biliary system	MP:0005370	9.92	ACVRL1 CTNNB1 GLA NF1 PECAM1 TP53
9	neoplasm	MP:0002006	9.7	CD34 CTNNB1 NF1 SDHD TP53 VEGFA
10	normal	MP:0002873	9.61	ACVRL1 CCR6 CTNNB1 ENG NF1 SDHD
11	renal/urinary system	MP:0005367	9.23	ACVRL1 CTNNB1 GLA NF1 PECAM1 TP53

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Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

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Genetic Tests for Cardiovascular Organ Benign Neoplasm

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Anatomical Context for Cardiovascular Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Organ Benign Neoplasm:

¹⁹

Blood

MalaCards organs/tissues related to Cardiovascular Organ Benign Neoplasm:

⁴⁰

Heart

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Publications for Cardiovascular Organ Benign Neoplasm

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Genes for Cardiovascular Organ Benign Neoplasm

Genes related to Cardiovascular Organ Benign Neoplasm (0 elite genes):

(show top 50) (show all 54)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPINA3	Serpin Family A Member 3	Protein Coding	9.21	DISEASES inferred ¹⁵ ¹⁵
2	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	8.66	DISEASES inferred ¹⁵
3	MIR143	MicroRNA 143	RNA Gene	8.41	DISEASES inferred ¹⁵ ¹⁵
4	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	8.32	DISEASES inferred ¹⁵
5	MIR132	MicroRNA 132	RNA Gene	8.22	DISEASES inferred ¹⁵ ¹⁵
6	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	8.19	DISEASES inferred ¹⁵ ¹⁵
7	MIR15A	MicroRNA 15a	RNA Gene	8.14	DISEASES inferred ¹⁵ ¹⁵
8	CD34	CD34 Molecule	Protein Coding	8.04	DISEASES inferred ¹⁵
9	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	8.04	DISEASES inferred ¹⁵
10	GLA	Galactosidase Alpha	Protein Coding	8.01	DISEASES inferred ¹⁵
11	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	7.94	DISEASES inferred ¹⁵
12	ENG	Endoglin	Protein Coding	7.89	DISEASES inferred ¹⁵
13	H2AC18	H2A Clustered Histone 18	Protein Coding	7.84	DISEASES inferred ¹⁵ ¹⁵
14	MIR195	MicroRNA 195	RNA Gene	7.58	DISEASES inferred ¹⁵ ¹⁵
15	RASA1	RAS P21 Protein Activator 1	Protein Coding	7.42	DISEASES inferred ¹⁵
16	CTNNB1	Catenin Beta 1	Protein Coding	7.42	DISEASES inferred ¹⁵
17	NF1	Neurofibromin 1	Protein Coding	7.39	DISEASES inferred ¹⁵
18	MIR139	MicroRNA 139	RNA Gene	7.32	DISEASES inferred ¹⁵ ¹⁵
19	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	7.27	DISEASES inferred ¹⁵
20	TP53	Tumor Protein P53	Protein Coding	7.26	DISEASES inferred ¹⁵
21	KDM4C	Lysine Demethylase 4C	Protein Coding	7.25	DISEASES inferred ¹⁵ ¹⁵
22	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	7.19	DISEASES inferred ¹⁵
23	SMAD4	SMAD Family Member 4	Protein Coding	7.18	DISEASES inferred ¹⁵
24	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	7.17	DISEASES inferred ¹⁵
25	GDF2	Growth Differentiation Factor 2	Protein Coding	7.17	DISEASES inferred ¹⁵
26	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	7.13	DISEASES inferred ¹⁵
27	KDR	Kinase Insert Domain Receptor	Protein Coding	7.11	DISEASES inferred ¹⁵
28	AFP	Alpha Fetoprotein	Protein Coding	7.09	DISEASES inferred ¹⁵
29	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	7.08	DISEASES inferred ¹⁵
30	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	7.03	DISEASES inferred ¹⁵
31	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	7.02	DISEASES inferred ¹⁵
32	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	6.98	DISEASES inferred ¹⁵
33	SYP	Synaptophysin	Protein Coding	6.98	DISEASES inferred ¹⁵
34	MEN1	Menin 1	Protein Coding	6.91	DISEASES inferred ¹⁵
35	MIR10A	MicroRNA 10a	RNA Gene	6.91	DISEASES inferred ¹⁵ ¹⁵
36	ELOB	Elongin B	Protein Coding	6.89	DISEASES inferred ¹⁵
37	ELOC	Elongin C	Protein Coding	6.88	DISEASES inferred ¹⁵
38	CUL2	Cullin 2	Protein Coding	6.88	DISEASES inferred ¹⁵
39	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	6.86	DISEASES inferred ¹⁵
40	PDPN	Podoplanin	Protein Coding	6.85	DISEASES inferred ¹⁵
41	TMEM127	Transmembrane Protein 127	Protein Coding	6.84	DISEASES inferred ¹⁵
42	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6.84	DISEASES inferred ¹⁵
43	FGF2	Fibroblast Growth Factor 2	Protein Coding	6.78	DISEASES inferred ¹⁵
44	ENO2	Enolase 2	Protein Coding	6.74	DISEASES inferred ¹⁵
45	CHGA	Chromogranin A	Protein Coding	6.72	DISEASES inferred ¹⁵
46	GLMN	Glomulin, FKBP Associated Protein	Protein Coding	6.72	DISEASES inferred ¹⁵
47	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6.71	DISEASES inferred ¹⁵
48	CAMTA1	Calmodulin Binding Transcription Activator 1	Protein Coding	6.71	DISEASES inferred ¹⁵
49	RET	Ret Proto-Oncogene	Protein Coding	6.7	DISEASES inferred ¹⁵
50	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	6.7	DISEASES inferred ¹⁵

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Variations for Cardiovascular Organ Benign Neoplasm

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Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

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Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.74	VHL VEGFA TP53 SERPINA3 RASA1 PECAM1
2	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁴	12.06	VEGFA RASA1 NF1 CTNNB1
3	MicroRNAs in cancer ³⁶	11.85	VEGFA TP53 MIR195 MIR15A MIR143
4	Integrated Breast Cancer Pathway ¹	11.75	VEGFA TP53 NF1 CTNNB1
5	Fluid shear stress and atherosclerosis ³⁶	11.6	VEGFA TP53 PECAM1 CTNNB1
6	HIF1Alpha Pathway ⁶³	11.23	VHL VEGFA TP53
7	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	10.89	VHL VEGFA RASA1 CTNNB1

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GO Terms for Cardiovascular Organ Benign Neoplasm

Cellular components related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell periphery	GO:0071944	8.8	PECAM1 CTNNB1 CD34

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of apoptotic process	GO:0043065	9.93	TP53 NF1 MIR195 MIR15A CTNNB1
2	angiogenesis	GO:0001525	9.92	VEGFA PECAM1 ENG ACVRL1
3	in utero embryonic development	GO:0001701	9.91	VEGFA TP53 CTNNB1 ACVRL1
4	positive regulation of gene expression	GO:0010628	9.91	VEGFA TP53 MIR132 ENG CTNNB1 CD34
5	negative regulation of angiogenesis	GO:0016525	9.81	NF1 MIR15A MIR143 CTNNB1
6	heart development	GO:0007507	9.8	TP53 NF1 ENG CTNNB1 ACVRL1
7	positive regulation of endothelial cell proliferation	GO:0001938	9.78	VEGFA NF1 ACVRL1
8	positive regulation of neuron apoptotic process	GO:0043525	9.74	TP53 NF1 CTNNB1
9	negative regulation of cell proliferation	GO:0008285	9.7	VHL TP53 NF1 MIR195 MIR15A CTNNB1
10	branching involved in blood vessel morphogenesis	GO:0001569	9.63	VEGFA ENG CTNNB1
11	endothelial tube morphogenesis	GO:0061154	9.6	CTNNB1 ACVRL1
12	vascular wound healing	GO:0061042	9.59	VEGFA CD34
13	dorsal aorta morphogenesis	GO:0035912	9.58	ENG ACVRL1
14	negative regulation of neuroblast proliferation	GO:0007406	9.58	TP53 NF1
15	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061419	9.56	VEGFA TP53
16	vasculogenesis	GO:0001570	9.56	VEGFA RASA1 ENG CTNNB1
17	regulation of blood vessel endothelial cell migration	GO:0043535	9.55	NF1 ACVRL1
18	artery morphogenesis	GO:0048844	9.54	VEGFA NF1 ENG
19	central nervous system vasculogenesis	GO:0022009	9.52	ENG CTNNB1
20	negative regulation of nitric oxide biosynthetic process	GO:0045019	9.5	MIR132 GLA CD34
21	endocardial cushion to mesenchymal transition	GO:0090500	9.49	ENG ACVRL1
22	glomerular endothelium development	GO:0072011	9.48	PECAM1 CD34
23	positive regulation of angiogenesis	GO:0045766	9.43	VEGFA MIR143 MIR132 ENG CD34 ACVRL1
24	negative regulation of gene expression	GO:0010629	9.23	VHL VEGFA TP53 MIR132 ENG CTNNB1

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transforming growth factor beta-activated receptor activity	GO:0005024	8.62	ENG ACVRL1

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Sources for Cardiovascular Organ Benign Neoplasm

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