MCID: CRD007
MIFTS: 28

Cardiovascular Organ Benign Neoplasm

Categories: Cancer diseases, Cardiovascular diseases
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Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0060091

Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology: 11 An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary: Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is ACVRL1 (Activin A Receptor Like Type 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. Affiliated tissues include blood and heart, and related phenotypes are Increased sensitivity to paclitaxel and normal

Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 419)
# Related Disease Score Top Affiliating Genes
1 hemangioma 32.5 VHL VEGFA PECAM1 ENG CTNNB1 CD34
2 pericardium leiomyoma 11.3
3 cerebrovascular benign neoplasm 11.3
4 angiomyoma 10.6 PECAM1 CD34
5 skin epithelioid hemangioma 10.5 PECAM1 CD34
6 aorta angiosarcoma 10.5 PECAM1 CD34
7 central nervous system angiosarcoma 10.5 PECAM1 CD34
8 intravascular angioleiomyoma 10.5 PECAM1 CD34
9 weber syndrome 10.5 RASA1 ENG ACVRL1
10 prostate angiosarcoma 10.5 VEGFA PECAM1 CD34
11 glomangiomyoma 10.5 PECAM1 MIR143 CD34
12 perivascular tumor 10.5 SERPINA3 PECAM1 CD34
13 glomeruloid hemangioma 10.5 VEGFA PECAM1 CD34
14 heart fibrosarcoma 10.5 PECAM1 CD34
15 benign perivascular tumor 10.5 PECAM1 MIR143 CD34
16 thyroid angiosarcoma 10.5 PECAM1 CD34
17 cystadenocarcinoma 10.5 VEGFA SERPINA3 NF1
18 sarcomatoid squamous cell skin carcinoma 10.5 SERPINA3 PECAM1 CD34
19 heart sarcoma 10.5 SERPINA3 PECAM1 CD34
20 acquired hemangioma 10.5 VEGFA PECAM1 CD34
21 bacillary angiomatosis 10.5 VEGFA PECAM1 CD34
22 glomangioma 10.5 PECAM1 CD34
23 lymphangiosarcoma 10.5 VEGFA PECAM1 CD34
24 glomangiomatosis 10.5 PECAM1 CD34
25 heart cancer 10.5 SERPINA3 PECAM1 CD34
26 conventional angiosarcoma 10.5 PECAM1 CD34
27 fumarate hydratase deficiency 10.5 VHL ACVRL1
28 telangiectasia, hereditary hemorrhagic, type 1 10.5 RASA1 ENG ACVRL1
29 bartonellosis 10.5 VEGFA PECAM1 CD34
30 pyogenic granuloma 10.5 VEGFA PECAM1 CD34
31 retinal hemangioblastoma 10.5 VHL VEGFA SERPINA3
32 childhood angiosarcoma 10.5 VEGFA PECAM1 CD34
33 hemangiopericytoma, malignant 10.5 SERPINA3 PECAM1 CD34
34 intermittent proptosis 10.5 PECAM1 NF1
35 gallbladder leiomyosarcoma 10.5 PECAM1 CD34
36 angiodysplasia 10.5 VEGFA ENG ACVRL1
37 venous hemangioma 10.5 PECAM1 CD34
38 ovarian angiosarcoma 10.5 PECAM1 CD34
39 kidney hemangiopericytoma 10.5 PECAM1 CD34
40 sweat gland disease 10.5 SERPINA3 GLA CD34
41 intussusception 10.5 VEGFA PECAM1 CD34
42 epiglottis cancer 10.5 ENG CD34
43 epithelioid neurofibroma 10.5 NF1 CD34
44 capillary disease 10.5 VEGFA PECAM1 CD34
45 malignant spindle cell melanoma 10.5 SERPINA3 NF1 CD34
46 ossifying fibroma 10.5 SERPINA3 NF1 CD34
47 malignant epithelioid hemangioendothelioma 10.5 SERPINA3 PECAM1
48 glomangiosarcoma 10.5 PECAM1 CD34
49 breast hemangioma 10.5 PECAM1 CD34
50 thyroid sarcoma 10.5 PECAM1 CD34

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:



Diseases related to Cardiovascular Organ Benign Neoplasm

Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased sensitivity to paclitaxel GR00112-A-0 8.62 SMAD4 VHL

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 10.13 ACVRL1 CCR6 CTNNB1 ENG MIR18A NF1
2 muscle MP:0005369 10.13 ACVRL1 CTNNB1 ENG GLA NF1 PECAM1
3 renal/urinary system MP:0005367 10.11 ACVRL1 CTNNB1 ENG GLA NF1 PECAM1
4 liver/biliary system MP:0005370 10.01 ACVRL1 CTNNB1 GLA NF1 PECAM1 SMAD4
5 cardiovascular system MP:0005385 10 ACVRL1 CCR6 CTNNB1 ENG GDF2 GLA
6 digestive/alimentary MP:0005381 9.97 ACVRL1 CTNNB1 ENG NF1 PECAM1 RASA1
7 limbs/digits/tail MP:0005371 9.91 CTNNB1 ENG NF1 RASA1 SMAD4 VEGFA
8 craniofacial MP:0005382 9.86 ACVRL1 CTNNB1 ENG NF1 RASA1 SMAD4
9 immune system MP:0005387 9.77 CCR6 CD34 CTNNB1 ENG GDF2 GLA
10 hematopoietic system MP:0005397 9.44 ACVRL1 CCR6 CD34 CTNNB1 ENG GDF2

Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials, NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

Genetic Tests for Cardiovascular Organ Benign Neoplasm

Anatomical Context for Cardiovascular Organ Benign Neoplasm

Organs/tissues related to Cardiovascular Organ Benign Neoplasm:

FMA: Blood
MalaCards : Heart

Publications for Cardiovascular Organ Benign Neoplasm

Variations for Cardiovascular Organ Benign Neoplasm

Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 ACVRL1 CCR6 CTNNB1 GDF2 NF1 RASA1
2 13.41 VHL VEGFA SYNGAP1 SMAD4 RASA1 NF1
3
Show member pathways
12.2 VEGFA RASA1 NF1 CTNNB1
4 11.88 VEGFA SMAD4 NF1 CTNNB1
5 11.68 SMAD4 ENG ACVRL1
6 11.53 VEGFA SMAD4 CTNNB1
7
Show member pathways
11.47 SMAD4 GDF2 ACVRL1
8 11.45 VEGFA SMAD4 ENG
9 11.33 VEGFA SMAD4 PECAM1
10 11.28 MIR195 MIR18A MIR17 MIR143
11
Show member pathways
11.05 SYNGAP1 RASA1 NF1
12 10.93 VEGFA SMAD4 MIR143 CTNNB1
13
Show member pathways
10.32 SMAD4 GDF2 ENG ACVRL1

GO Terms for Cardiovascular Organ Benign Neoplasm

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.33 VEGFA MIR17 GDF2 ENG CTNNB1 CD34
2 negative regulation of cell population proliferation GO:0008285 10.31 VHL SMAD4 NF1 MIR195 CTNNB1 ACVRL1
3 angiogenesis GO:0001525 10.27 VEGFA NF1 GDF2 ENG ACVRL1
4 osteoblast differentiation GO:0001649 10.17 CTNNB1 GDF2 NF1 SMAD4
5 BMP signaling pathway GO:0030509 10.17 ACVRL1 ENG GDF2 SMAD4
6 negative regulation of angiogenesis GO:0016525 10.13 NF1 MIR143 GDF2 CTNNB1
7 response to hypoxia GO:0001666 10.13 VEGFA SMAD4 NF1 ENG ACVRL1
8 positive regulation of endothelial cell proliferation GO:0001938 10.1 VEGFA NF1 GDF2 ACVRL1
9 cellular response to BMP stimulus GO:0071773 10.08 ACVRL1 GDF2 SMAD4
10 epithelial to mesenchymal transition GO:0001837 10.04 SMAD4 ENG CTNNB1
11 artery morphogenesis GO:0048844 10.03 ENG NF1 VEGFA
12 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 10.01 SMAD4 GDF2 ENG ACVRL1
13 activin receptor signaling pathway GO:0032924 9.99 ACVRL1 GDF2 SMAD4
14 negative regulation of Ras protein signal transduction GO:0046580 9.97 SYNGAP1 RASA1 NF1
15 positive regulation of BMP signaling pathway GO:0030513 9.97 SMAD4 GDF2 ENG ACVRL1
16 negative regulation of gene expression GO:0010629 9.97 ACVRL1 CD34 CTNNB1 ENG MIR17 VEGFA
17 blood vessel morphogenesis GO:0048514 9.95 RASA1 GDF2 ACVRL1
18 regulation of blood vessel endothelial cell migration GO:0043535 9.93 NF1 ACVRL1
19 positive regulation of endothelial cell differentiation GO:0045603 9.91 ACVRL1 CTNNB1 GDF2
20 glomerular endothelium development GO:0072011 9.9 PECAM1 CD34
21 central nervous system vasculogenesis GO:0022009 9.89 ENG CTNNB1
22 negative regulation of endothelial cell proliferation GO:0001937 9.87 ACVRL1 ENG GDF2 NF1
23 branching involved in blood vessel morphogenesis GO:0001569 9.86 VEGFA GDF2 ENG CTNNB1
24 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.76 SMAD4 MIR195 MIR17
25 positive regulation of angiogenesis GO:0045766 9.7 VEGFA MIR143 GDF2 ENG CD34 ACVRL1
26 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.54 MIR17 MIR143
27 endocardial cushion to mesenchymal transition GO:0090500 9.52 ENG ACVRL1
28 vasculogenesis GO:0001570 9.28 VEGFA RASA1 GDF2 ENG CTNNB1

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA base-pairing translational repressor activity GO:1903231 9.26 MIR195 MIR18A MIR17 MIR143
2 sulfate binding GO:0043199 8.92 SMAD4 CD34

Sources for Cardiovascular Organ Benign Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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