MCID: CRD007
MIFTS: 32

Cardiovascular Organ Benign Neoplasm

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060091

Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary : Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Pathways in cancer and ErbB signaling pathway. Affiliated tissues include heart, liver and skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 hemangioma 30.7 CD34 KDR PECAM1 PROX1 RET SLC2A1
2 pericardium leiomyoma 11.2
3 cerebrovascular benign neoplasm 11.2
4 hemangioendothelioma 10.3 KDR PECAM1
5 intravascular papillary endothelial hyperplasia 10.3 SERPINA3 VEGFA
6 hemangioblastoma 10.3 SLC2A1 VEGFA VHL
7 arteriovenous malformation 10.3 ACVRL1 RASA1 VEGFA
8 neural crest tumor 10.3 SDHB SDHC SDHD
9 extra-adrenal pheochromocytoma 10.3 SDHB SDHC SDHD
10 persistent generalized lymphadenopathy 10.3 SDHB SDHC SDHD
11 chondroma 10.3 SDHB SDHC SDHD
12 paraganglioma and gastric stromal sarcoma 10.3 SDHB SDHC SDHD
13 carney triad 10.3 SDHB SDHC SDHD
14 plethora of newborn 10.3 SDHB SDHC SDHD
15 retinal hemangioblastoma 10.3 SERPINA3 VEGFA VHL
16 lymph node disease 10.3 SDHB SDHC SDHD
17 mitochondrial complex ii deficiency 10.3 SDHB SDHC SDHD
18 lymphatic system disease 10.3 SDHB SDHC SDHD
19 radiation proctitis 10.2 KDR PECAM1 VEGFA
20 hydrocele 10.2 AFP PECAM1 VEGFA
21 renal pelvis adenocarcinoma 10.2 AFP SLC2A1
22 pediatric angiosarcoma 10.2 CD34 VEGFA
23 lymphangioma 10.1 KDR PROX1 VEGFA
24 telangiectasis 10.1 ACVRL1 AFP VEGFA
25 paragangliomas 1 10.1 RET SDHB SDHC SDHD
26 adrenal medulla cancer 10.1 RET SDHB SDHC SDHD
27 glomeruloid hemangioma 10.1 CD34 VEGFA
28 urachal adenocarcinoma 10.1 AFP NF1
29 peliosis hepatis 10.1 AFP MEN1 VEGFA
30 renal cell carcinoma, papillary, 1 10.1 ELOC SDHB VHL
31 angiokeratoma circumscriptum 10.1 KDR RASA1 SLC2A1 VEGFA
32 multiple endocrine neoplasia, type i 10.1 MEN1 RET SDHB SDHD
33 ovarian germ cell cancer 10.0 AFP RET
34 angiosarcoma 10.0 KDR PECAM1 PROX1 VEGFA
35 arteriovenous malformations of the brain 10.0 ACVRL1 KDR RASA1 VEGFA
36 hemangioma of liver 10.0 CD34 VHL
37 kidney cancer 10.0 KDR VEGFA VHL
38 supratentorial cancer 10.0 KDR NF1 VEGFA
39 cerebrum cancer 10.0 KDR NF1 VEGFA
40 lymphangiosarcoma 10.0 CD34 PROX1 VEGFA
41 clear cell renal cell carcinoma 10.0 KDR SLC2A1 VEGFA VHL
42 ovarian solid teratoma 10.0 AFP CD34
43 pancreatic serous cystadenoma 10.0 VEGFA VHL VHLL
44 connective tissue cancer 10.0 CD34 SERPINA3 VEGFA
45 malignant pineal area germ cell neoplasm 10.0 AFP CD34
46 hereditary paraganglioma-pheochromocytoma syndromes 10.0 RET SDHB SDHC SDHD VHL
47 hyperparathyroidism 2 with jaw tumors 10.0 MEN1 RET
48 sternum cancer 10.0 AFP CD34
49 placental insufficiency 10.0 AFP KDR VEGFA
50 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.0 ACVRL1 NF1 PECAM1 RASA1 SLC2A1

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:



Diseases related to Cardiovascular Organ Benign Neoplasm

Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

27 (show all 32)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.79 ACVRL1 KDR NF1 RET SDHD VHL
2 Decreased viability GR00221-A-2 10.79 ACVRL1 KDR NF1 RET SDHD VHL
3 Decreased viability GR00221-A-3 10.79 ACVRL1 KDR RASA1
4 Decreased viability GR00221-A-4 10.79 ACVRL1 KDR NF1 RET SDHD RASA1
5 Decreased viability GR00231-A 10.79 RET
6 Decreased viability GR00301-A 10.79 RET VHL
7 Decreased viability GR00381-A-1 10.79 SDHD RASA1
8 Decreased viability GR00402-S-2 10.79 ACVRL1 KDR NF1 RET SDHD VHL
9 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.12 RASA1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.12 ACVRL1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.12 MEN1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.12 MEN1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.12 MEN1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.12 ACVRL1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.12 SDHC
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.12 ACVRL1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.12 MEN1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-188 10.12 SDHC SDHD
19 Increased shRNA abundance (Z-score > 2) GR00366-A-197 10.12 SDHC
20 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.12 ACVRL1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.12 RASA1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.12 ACVRL1 MEN1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.12 MEN1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.12 MEN1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.12 RASA1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.12 ACVRL1 SDHC
27 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.12 ACVRL1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.12 ACVRL1 MEN1 RASA1 SDHC SDHD
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.12 ACVRL1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.12 RASA1
31 shRNA abundance <= 50% GR00343-S 9.32 ACVRL1 KDR MEN1 NF1 PROX1 RET
32 Decreased sensitivity to paclitaxel GR00112-A-0 9.26 NF1 VHL

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

47 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.38 CD34 GLA KDR MEN1 NF1 PECAM1
2 homeostasis/metabolism MP:0005376 10.38 ACVRL1 AFP CD34 GLA KDR MEN1
3 cardiovascular system MP:0005385 10.35 ACVRL1 GLA KDR MEN1 NF1 PECAM1
4 growth/size/body region MP:0005378 10.29 ACVRL1 GLA KDR MEN1 NF1 PROX1
5 mortality/aging MP:0010768 10.28 ACVRL1 AFP GLA KDR MEN1 NF1
6 hematopoietic system MP:0005397 10.27 ACVRL1 CD34 KDR NF1 PECAM1 PROX1
7 embryo MP:0005380 10.24 ACVRL1 KDR MEN1 NF1 RASA1 RET
8 digestive/alimentary MP:0005381 10.2 ACVRL1 MEN1 NF1 PECAM1 PROX1 RASA1
9 immune system MP:0005387 10.2 CD34 GLA KDR MEN1 NF1 PECAM1
10 endocrine/exocrine gland MP:0005379 10.18 AFP MEN1 NF1 PROX1 RET SDHB
11 liver/biliary system MP:0005370 10.13 ACVRL1 AFP GLA KDR MEN1 NF1
12 muscle MP:0005369 10.11 ACVRL1 GLA KDR MEN1 NF1 PECAM1
13 craniofacial MP:0005382 10.1 ACVRL1 KDR MEN1 NF1 RASA1 VEGFA
14 nervous system MP:0003631 10 ACVRL1 GLA KDR MEN1 NF1 PROX1
15 neoplasm MP:0002006 9.97 AFP CD34 MEN1 NF1 RET SDHB
16 normal MP:0002873 9.81 ACVRL1 KDR NF1 PROX1 RET SDHB
17 renal/urinary system MP:0005367 9.56 ACVRL1 GLA NF1 PECAM1 RET SDHB
18 respiratory system MP:0005388 9.17 ACVRL1 KDR NF1 PECAM1 PROX1 RET

Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

Genetic Tests for Cardiovascular Organ Benign Neoplasm

Anatomical Context for Cardiovascular Organ Benign Neoplasm

MalaCards organs/tissues related to Cardiovascular Organ Benign Neoplasm:

42
Heart, Liver, Skin, Brain, Kidney, Lymph Node, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Organ Benign Neoplasm:

20
The Blood

Publications for Cardiovascular Organ Benign Neoplasm

Variations for Cardiovascular Organ Benign Neoplasm

Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1 12.56 ELOC RET SLC2A1 VEGFA VHL
2
Show member pathways
12.33 ELOC SLC2A1 VEGFA VHL
3
Show member pathways
12.09 KDR NF1 RASA1 VEGFA
4 11.75 AFP KDR PROX1 VEGFA
5
Show member pathways
11.7 SDHB SDHC SDHD
6 11.58 KDR PECAM1 PROX1
7 11.56 ELOC SLC2A1 VEGFA VHL
8
Show member pathways
11.42 KDR RASA1 VEGFA VHL
9 11.23 NF1 RET VEGFA
10 10.99 ELOC SLC2A1 VEGFA VHL
11 10.75 VEGFA VHL
12 10.67 ELOC VHL
13 10.55 ELOC KDR SLC2A1 VEGFA VHL

GO Terms for Cardiovascular Organ Benign Neoplasm

Cellular components related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.56 KDR PECAM1 RET SLC2A1
2 VCB complex GO:0030891 9.16 VHL VHLL
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.95 ACVRL1 MEN1 NF1 PROX1 VHL
2 negative regulation of apoptotic process GO:0043066 9.91 KDR RASA1 VEGFA VHL
3 angiogenesis GO:0001525 9.88 ACVRL1 KDR PECAM1 VEGFA
4 MAPK cascade GO:0000165 9.86 MEN1 NF1 RASA1 RET
5 response to hypoxia GO:0001666 9.76 ACVRL1 NF1 SLC2A1 VEGFA
6 vasculogenesis GO:0001570 9.71 KDR RASA1 VEGFA
7 positive regulation of angiogenesis GO:0045766 9.67 ACVRL1 CD34 KDR VEGFA
8 negative regulation of nitric oxide biosynthetic process GO:0045019 9.62 CD34 GLA
9 vascular endothelial growth factor signaling pathway GO:0038084 9.61 KDR VEGFA
10 positive regulation of endothelial cell migration GO:0010595 9.61 KDR PROX1 VEGFA
11 lymphangiogenesis GO:0001946 9.6 ACVRL1 PROX1
12 positive regulation of positive chemotaxis GO:0050927 9.59 KDR VEGFA
13 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 9.58 NF1 RET
14 positive regulation of vasculogenesis GO:2001214 9.57 CD34 KDR
15 endothelium development GO:0003158 9.52 CD34 KDR
16 lymphatic endothelial cell differentiation GO:0060836 9.51 ACVRL1 PROX1
17 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.49 SDHC SDHD
18 regulation of blood vessel endothelial cell migration GO:0043535 9.48 ACVRL1 NF1
19 tricarboxylic acid cycle GO:0006099 9.43 SDHB SDHC SDHD
20 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.4 KDR VEGFA
21 negative regulation of gene expression GO:0010629 9.35 ACVRL1 CD34 KDR VEGFA VHL
22 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.33 ELOC VEGFA VHL
23 glomerular endothelium development GO:0072011 9.32 CD34 PECAM1
24 positive regulation of endothelial cell proliferation GO:0001938 9.02 ACVRL1 KDR NF1 PROX1 VEGFA

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.43 SDHB SDHC SDHD
2 ubiquinone binding GO:0048039 8.96 SDHB SDHD
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD
4 protein binding GO:0005515 10.09 ACVRL1 AFP ELOC GLA KDR MEN1

Sources for Cardiovascular Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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