MCID: CRD007
MIFTS: 25

Cardiovascular Organ Benign Neoplasm

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060091

Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary : Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include blood, and related phenotypes are Decreased sensitivity to paclitaxel and cardiovascular system

Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
# Related Disease Score Top Affiliating Genes
1 hemangioma 32.4 VHL VEGFA PECAM1 ENG CTNNB1 CD34
2 pericardium leiomyoma 11.2
3 cerebrovascular benign neoplasm 11.2
4 skin epithelioid hemangioma 10.6 PECAM1 CD34
5 aortic malignant tumor 10.6 PECAM1 CD34
6 central nervous system angiosarcoma 10.6 PECAM1 CD34
7 intravascular angioleiomyoma 10.6 PECAM1 CD34
8 intravascular papillary endothelial hyperplasia 10.6 VEGFA SERPINA3
9 heart fibrosarcoma 10.6 PECAM1 CD34
10 ovarian angiosarcoma 10.6 PECAM1 CD34
11 pulmonary arteriovenous malformation 10.6 ENG ACVRL1
12 sarcomatoid squamous cell skin carcinoma 10.6 SERPINA3 PECAM1 CD34
13 prostate angiosarcoma 10.6 VEGFA PECAM1 CD34
14 angiosarcoma 10.6 VEGFA PECAM1 CD34
15 central nervous system hemangioma 10.6 VEGFA PECAM1 CD34
16 conventional angiosarcoma 10.6 PECAM1 CD34
17 heart cancer 10.6 SERPINA3 PECAM1 CD34
18 pediatric angiosarcoma 10.5 VEGFA PECAM1 CD34
19 retroperitoneal hemangiopericytoma 10.5 VEGFA PECAM1 CD34
20 cystic lymphangioma 10.5 SERPINA3 PECAM1 CD34
21 myofibroma 10.5 SERPINA3 MIR143 CD34
22 mechanical ectropion 10.5 NF1 CD34
23 bacillary angiomatosis 10.5 VEGFA PECAM1 CD34
24 gallbladder leiomyosarcoma 10.5 PECAM1 CD34
25 thyroid sarcoma 10.5 PECAM1 CD34
26 angiomyoma 10.5 PECAM1 CD34
27 retinal hemangioblastoma 10.5 VHL VEGFA SERPINA3
28 capillary lymphangioma 10.5 PECAM1 ENG CD34
29 bartonellosis 10.5 VEGFA PECAM1 CD34
30 central nervous system vasculitis 10.5 VEGFA SERPINA3 CCR6
31 glomangiosarcoma 10.5 PECAM1 CD34
32 breast hemangioma 10.5 PECAM1 CD34
33 hemangioma of spleen 10.5 PECAM1 CD34
34 sebaceous gland disease 10.5 SERPINA3 MIR132 CCR6
35 hemangiopericytoma, malignant 10.5 SERPINA3 PECAM1 CD34
36 mesenchymal cell neoplasm 10.5 SERPINA3 PECAM1 CD34
37 epiglottis cancer 10.5 ENG CD34
38 subungual glomus tumor 10.5 PECAM1 NF1 CD34
39 progressive relapsing multiple sclerosis 10.5 SERPINA3 H2AC18 CCR6
40 neurofibroma 10.5 VEGFA NF1 CD34
41 epithelioid neurofibroma 10.5 NF1 CD34
42 juvenile nasopharyngeal angiofibroma 10.5 VEGFA PECAM1 ENG
43 pacinian tumor 10.5 NF1 CD34
44 angiodysplasia 10.5 VEGFA ENG ACVRL1
45 intravascular fasciitis 10.5 PECAM1 CTNNB1 CD34
46 intramuscular hemangioma 10.5 PECAM1 CD34
47 malignant spindle cell melanoma 10.5 SERPINA3 NF1 CD34
48 skin tag 10.5 SYNGAP1 SERPINA3 CD34
49 liposarcoma of bone 10.5 PECAM1 CD34
50 adamantinous craniopharyngioma 10.5 VEGFA SERPINA3 CTNNB1

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:



Diseases related to Cardiovascular Organ Benign Neoplasm

Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.32 NF1

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ACVRL1 CTNNB1 ENG GDF2 GLA NF1
2 digestive/alimentary MP:0005381 9.56 ACVRL1 CTNNB1 ENG NF1 PECAM1 RASA1
3 muscle MP:0005369 9.28 ACVRL1 CTNNB1 ENG GLA NF1 PECAM1

Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

Genetic Tests for Cardiovascular Organ Benign Neoplasm

Anatomical Context for Cardiovascular Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Organ Benign Neoplasm:

19
Blood

Publications for Cardiovascular Organ Benign Neoplasm

Variations for Cardiovascular Organ Benign Neoplasm

Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 VHL VEGFA SYNGAP1 SERPINA3 RASA1 PECAM1
2
Show member pathways
13.28 VHL VEGFA SYNGAP1 RASA1 NF1 GDF2
3
Show member pathways
12 VEGFA SYNGAP1 RASA1 NF1 CTNNB1
4
Show member pathways
11.95 VEGFA RASA1 NF1 CTNNB1
5
Show member pathways
10.89 VHL VEGFA RASA1 CTNNB1

GO Terms for Cardiovascular Organ Benign Neoplasm

Cellular components related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 VEGFA SERPINA3 PECAM1 MIR15A MIR143 MIR132

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.02 VHL NF1 MIR15A CTNNB1 ACVRL1
2 positive regulation of gene expression GO:0010628 9.99 VEGFA MIR132 GDF2 ENG CTNNB1 CD34
3 angiogenesis GO:0001525 9.95 VEGFA GDF2 ENG ACVRL1
4 heart development GO:0007507 9.93 NF1 ENG CTNNB1 ACVRL1
5 positive regulation of protein kinase B signaling GO:0051897 9.9 VEGFA MIR143 MIR132 ENG
6 response to hypoxia GO:0001666 9.88 VEGFA NF1 ENG ACVRL1
7 regulation of GTPase activity GO:0043087 9.83 SYNGAP1 RASA1 NF1
8 BMP signaling pathway GO:0030509 9.83 GDF2 ENG ACVRL1
9 positive regulation of endothelial cell proliferation GO:0001938 9.8 VEGFA GDF2 ACVRL1
10 negative regulation of angiogenesis GO:0016525 9.77 NF1 MIR15A MIR143 GDF2 CTNNB1
11 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.74 GDF2 ENG ACVRL1
12 negative regulation of blood vessel endothelial cell migration GO:0043537 9.73 MIR132 GDF2 ACVRL1
13 positive regulation of BMP signaling pathway GO:0030513 9.72 GDF2 ENG ACVRL1
14 negative regulation of gene expression GO:0010629 9.7 VHL VEGFA MIR132 ENG CTNNB1 CD34
15 blood vessel morphogenesis GO:0048514 9.67 RASA1 GDF2 ACVRL1
16 artery morphogenesis GO:0048844 9.65 VEGFA NF1 ENG
17 smooth muscle tissue development GO:0048745 9.64 NF1 ENG
18 negative regulation of oligodendrocyte differentiation GO:0048715 9.64 NF1 CTNNB1
19 negative regulation of nitric oxide biosynthetic process GO:0045019 9.63 MIR132 GLA CD34
20 endothelial tube morphogenesis GO:0061154 9.62 CTNNB1 ACVRL1
21 negative regulation of endothelial cell proliferation GO:0001937 9.62 NF1 GDF2 ENG ACVRL1
22 vascular wound healing GO:0061042 9.61 VEGFA CD34
23 dorsal aorta morphogenesis GO:0035912 9.61 ENG ACVRL1
24 positive regulation of endothelial cell differentiation GO:0045603 9.61 GDF2 CTNNB1 ACVRL1
25 regulation of blood vessel endothelial cell migration GO:0043535 9.59 NF1 ACVRL1
26 central nervous system vasculogenesis GO:0022009 9.58 ENG CTNNB1
27 negative regulation of nitric-oxide synthase activity GO:0051001 9.58 MIR132 GLA ENG
28 branching involved in blood vessel morphogenesis GO:0001569 9.56 VEGFA GDF2 ENG CTNNB1
29 endocardial cushion to mesenchymal transition GO:0090500 9.54 ENG ACVRL1
30 glomerular endothelium development GO:0072011 9.52 PECAM1 CD34
31 vasculogenesis GO:0001570 9.35 VEGFA RASA1 GDF2 ENG CTNNB1
32 positive regulation of angiogenesis GO:0045766 9.17 VEGFA MIR143 MIR132 GDF2 ENG CD34

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta-activated receptor activity GO:0005024 8.62 ENG ACVRL1

Sources for Cardiovascular Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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