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MCID: CRD007
MIFTS: 29

Cardiovascular Organ Benign Neoplasm

Categories: Cancer diseases, Cardiovascular diseases
Genes Tissues Related diseases Pathways
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Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

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MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm 12 15

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060091
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Summaries for Cardiovascular Organ Benign Neoplasm

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Disease Ontology : 12 An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary : Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is ACVRL1 (Activin A Receptor Like Type 1), and among its related pathways/superpathways are ErbB signaling pathway and Development VEGF signaling via VEGFR2 - generic cascades. Affiliated tissues include blood, heart and skin, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Cardiovascular Organ Benign Neoplasm

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Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 257)
# Related Disease Score Top Affiliating Genes
1 hemangioma 32.4 VHL VEGFA SYP SLC2A1 PECAM1 KDR
2 pericardium leiomyoma 11.4
3 cerebrovascular benign neoplasm 11.4
4 glomangioma 10.8 PECAM1 CD34
5 skin epithelioid hemangioma 10.8 PECAM1 CD34
6 central nervous system angiosarcoma 10.8 PECAM1 CD34
7 intravascular angioleiomyoma 10.8 PECAM1 CD34
8 heart fibrosarcoma 10.8 PECAM1 CD34
9 pulmonary arteriovenous malformation 10.8 ENG ACVRL1
10 intravascular papillary endothelial hyperplasia 10.7 VEGFA SERPINA3
11 ovarian angiosarcoma 10.7 PECAM1 CD34
12 conventional angiosarcoma 10.7 PECAM1 CD34
13 angiomyoma 10.7 PECAM1 CD34
14 mechanical ectropion 10.7 NF1 CD34
15 fibroma 10.7 SERPINA3 PECAM1 CD34
16 aortic malignant tumor 10.7 PECAM1 CD34
17 hemangioma of spleen 10.7 PECAM1 CD34
18 ovary sarcoma 10.7 PECAM1 CD34
19 epithelioid neurofibroma 10.7 NF1 CD34
20 ovarian solid teratoma 10.7 CD34 AFP
21 pacinian tumor 10.7 NF1 CD34
22 prostate angiosarcoma 10.7 VEGFA PECAM1 CD34
23 angiokeratoma of mibelli 10.7 KDR GLA
24 heart leiomyosarcoma 10.7 PECAM1 CD34
25 acquired hemangioma 10.7 VEGFA PECAM1
26 pediatric angiosarcoma 10.7 VEGFA PECAM1 CD34
27 neural crest tumor 10.7 SDHD SDHB
28 central nervous system hemangioma 10.7 PECAM1 NF1 CD34
29 retroperitoneal hemangiopericytoma 10.7 VEGFA PECAM1 CD34
30 lymphangiosarcoma 10.7 VEGFA PECAM1 CD34
31 mixed hepatoblastoma 10.7 SERPINA3 AFP
32 heart cancer 10.7 SERPINA3 PECAM1 CD34
33 liposarcoma of bone 10.7 PECAM1 CD34
34 dermis tumor 10.7 SERPINA3 PECAM1 CD34
35 capillary lymphangioma 10.7 PECAM1 ENG CD34
36 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.7 PECAM1 ENG ACVRL1
37 peripheral nerve schwannoma 10.7 SERPINA3 NF1
38 subungual glomus tumor 10.7 PECAM1 NF1 CD34
39 lung meningioma 10.7 SYP CD34
40 angiokeratoma of fordyce 10.7 PECAM1 NF1 GLA
41 glomangiosarcoma 10.7 SYP CD34
42 urachal adenocarcinoma 10.7 NF1 AFP
43 juvenile nasopharyngeal angiofibroma 10.7 VEGFA PECAM1 ENG
44 liver inflammatory pseudotumor 10.7 CD34 AFP
45 angiodysplasia 10.7 VEGFA ENG ACVRL1
46 acinar cell cystadenocarcinoma 10.7 SYP SERPINA3
47 papillary adenofibroma 10.7 CD34 AFP
48 malignant spindle cell melanoma 10.7 SERPINA3 NF1 CD34
49 plexiform schwannoma 10.7 NF1 CD34
50 kaposiform hemangioendothelioma 10.7 PECAM1 KDR CD34

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:



Diseases related to Cardiovascular Organ Benign Neoplasm
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Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

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GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.16 ACVRL1 KDR NF1 SDHD VHL
2 Decreased viability GR00221-A-2 10.16 ACVRL1 KDR NF1 SDHD VHL
3 Decreased viability GR00221-A-3 10.16 ACVRL1 KDR RASA1
4 Decreased viability GR00221-A-4 10.16 ACVRL1 KDR NF1 SDHD RASA1
5 Decreased viability GR00301-A 10.16 VHL
6 Decreased viability GR00381-A-1 10.16 SDHD RASA1
7 Decreased viability GR00402-S-2 10.16 ACVRL1 KDR NF1 SDHD VHL RASA1
8 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 NF1 VHL

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 ACVRL1 ENG GDF2 GLA KDR NF1
2 homeostasis/metabolism MP:0005376 10.13 ACVRL1 AFP CD34 ENG GLA KDR
3 embryo MP:0005380 10.02 ACVRL1 ENG KDR NF1 RASA1 SDHD
4 craniofacial MP:0005382 9.95 ACVRL1 ENG KDR NF1 RASA1 VEGFA
5 liver/biliary system MP:0005370 9.86 ACVRL1 AFP GLA KDR NF1 PECAM1
6 muscle MP:0005369 9.81 ACVRL1 ENG GLA KDR NF1 PECAM1
7 neoplasm MP:0002006 9.5 AFP CD34 NF1 SDHB SDHD VEGFA
8 normal MP:0002873 9.28 ACVRL1 ENG KDR NF1 SDHB SDHD
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Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

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Search Clinical Trials , NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

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Genetic Tests for Cardiovascular Organ Benign Neoplasm

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Anatomical Context for Cardiovascular Organ Benign Neoplasm

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The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Organ Benign Neoplasm:

19
Blood

MalaCards organs/tissues related to Cardiovascular Organ Benign Neoplasm:

40
Heart, Skin, Liver, Breast, Ovary, Bone, Spleen
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Publications for Cardiovascular Organ Benign Neoplasm

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Variations for Cardiovascular Organ Benign Neoplasm

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Expression for Cardiovascular Organ Benign Neoplasm

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Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.
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Pathways for Cardiovascular Organ Benign Neoplasm

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Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
ErbB signaling pathway 1 36
Show member pathways
 12.19 VHL VEGFA SLC2A1 NF1 KDR ELOC
2
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.12 VEGFA RASA1 NF1 KDR
3
HIF-1 signaling pathway 36
11.66 VHL VEGFA SLC2A1 ELOC
4
Angiogenesis (CST) 4
11.58 PECAM1 KDR ENG
5
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.52 VHL VEGFA RASA1 KDR
6
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.48 VEGFA SYP SLC2A1
7
HIF-1-alpha transcription factor network 1
11.36 VEGFA SLC2A1 ENG
8
HIF1Alpha Pathway 63
10.99 VHL VEGFA SLC2A1 ELOC
9
HIF-2-alpha transcription factor network 1
10.55 VHL VEGFA SLC2A1 KDR ELOC
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GO Terms for Cardiovascular Organ Benign Neoplasm

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Cellular components related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHD SDHB

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.02 VEGFA MIR132 GDF2 ENG CD34
2 positive regulation of protein phosphorylation GO:0001934 9.91 VEGFA PECAM1 KDR ENG
3 response to hypoxia GO:0001666 9.88 VEGFA SLC2A1 NF1 ACVRL1
4 BMP signaling pathway GO:0030509 9.82 GDF2 ENG ACVRL1
5 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.8 VHL VEGFA ELOC
6 angiogenesis GO:0001525 9.8 VEGFA PECAM1 KDR GDF2 ENG ACVRL1
7 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.75 GDF2 ENG ACVRL1
8 negative regulation of blood vessel endothelial cell migration GO:0043537 9.73 MIR132 GDF2 ACVRL1
9 negative regulation of endothelial cell proliferation GO:0001937 9.72 NF1 GDF2 ACVRL1
10 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.71 VEGFA MIR132 KDR
11 positive regulation of BMP signaling pathway GO:0030513 9.7 GDF2 ENG ACVRL1
12 negative regulation of DNA biosynthetic process GO:2000279 9.65 GDF2 ACVRL1
13 negative regulation of nitric-oxide synthase activity GO:0051001 9.65 MIR132 GLA
14 sprouting angiogenesis GO:0002040 9.65 VEGFA KDR ENG
15 positive regulation of endothelial cell proliferation GO:0001938 9.65 VEGFA NF1 KDR GDF2 ACVRL1
16 positive regulation of positive chemotaxis GO:0050927 9.64 VEGFA KDR
17 positive regulation of vasculogenesis GO:2001214 9.63 KDR CD34
18 smooth muscle tissue development GO:0048745 9.63 NF1 ENG
19 blood vessel morphogenesis GO:0048514 9.63 RASA1 GDF2 ACVRL1
20 dorsal aorta morphogenesis GO:0035912 9.61 ENG ACVRL1
21 branching involved in blood vessel morphogenesis GO:0001569 9.61 VEGFA GDF2 ENG
22 regulation of blood vessel endothelial cell migration GO:0043535 9.6 NF1 ACVRL1
23 endothelium development GO:0003158 9.59 KDR CD34
24 artery morphogenesis GO:0048844 9.58 VEGFA NF1 ENG
25 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.57 VEGFA KDR
26 vasculogenesis GO:0001570 9.55 VEGFA RASA1 KDR GDF2 ENG
27 negative regulation of nitric oxide biosynthetic process GO:0045019 9.54 MIR132 GLA CD34
28 endocardial cushion to mesenchymal transition GO:0090500 9.51 ENG ACVRL1
29 negative regulation of gene expression GO:0010629 9.5 VHL VEGFA MIR132 KDR ENG CD34
30 glomerular endothelium development GO:0072011 9.49 PECAM1 CD34
31 positive regulation of angiogenesis GO:0045766 9.17 VEGFA MIR132 KDR GDF2 ENG CD34

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 8.96 SDHD SDHB
2 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHD SDHB
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Sources for Cardiovascular Organ Benign Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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