MCID: CRD007
MIFTS: 27

Cardiovascular Organ Benign Neoplasm

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Cardiovascular Organ Benign Neoplasm

MalaCards integrated aliases for Cardiovascular Organ Benign Neoplasm:

Name: Cardiovascular Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060091

Summaries for Cardiovascular Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm disease located in the blood, heart, blood vessels or the lymphatic system.

MalaCards based summary : Cardiovascular Organ Benign Neoplasm is related to hemangioma and pericardium leiomyoma. An important gene associated with Cardiovascular Organ Benign Neoplasm is ACVRL1 (Activin A Receptor Like Type 1), and among its related pathways/superpathways are Pathways in cancer and MAPK signaling pathway. Affiliated tissues include heart and blood, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cardiovascular Organ Benign Neoplasm

Diseases related to Cardiovascular Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 hemangioma 30.6 VHL VEGFA SLC2A1 PROX1 PECAM1 KDR
2 pericardium leiomyoma 11.4
3 cerebrovascular benign neoplasm 11.4
4 pulmonary arteriovenous malformation 10.7 ENG ACVRL1
5 angiodysplasia 10.6 VEGFA ENG ACVRL1
6 weber syndrome 10.6 RASA1 ENG ACVRL1
7 telangiectasis 10.6 VEGFA ENG ACVRL1
8 juvenile nasopharyngeal angiofibroma 10.6 VEGFA PECAM1 ENG
9 neural crest tumor 10.6 SDHD SDHB
10 intravascular papillary endothelial hyperplasia 10.5 VEGFA SERPINA3
11 radiation proctitis 10.5 VEGFA PECAM1 KDR
12 hemangioblastoma 10.5 VHL VEGFA SLC2A1
13 drug-induced lupus erythematosus 10.5 VEGFA KDR ENG
14 hemifacial spasm 10.5 VEGFA FLT4
15 retinal hemangioblastoma 10.5 VHL VEGFA SERPINA3
16 hereditary paraganglioma-pheochromocytoma syndromes 10.5 VHL SDHD SDHB
17 arteriovenous malformation 10.4 VEGFA RASA1 ENG ACVRL1
18 extra-adrenal pheochromocytoma 10.4 SDHD SDHB
19 hydrocele 10.4 VEGFA PECAM1 FLT4
20 hemangioendothelioma 10.4 PECAM1 KDR FLT4
21 pediatric angiosarcoma 10.4 VEGFA CD34
22 gorham's disease 10.4 GLMN FLT4
23 pancreatic serous cystadenoma 10.4 VHL VEGFA
24 lymphatic malformations 10.4 PROX1 FLT4
25 angiokeratoma circumscriptum 10.3 VEGFA SLC2A1 RASA1 KDR
26 kidney cancer 10.3 VHL VEGFA KDR
27 klippel-trenaunay-weber syndrome 10.3 RASA1 GLMN FLT4
28 glomeruloid hemangioma 10.3 VEGFA ENG CD34
29 lymphatic system disease 10.3 SDHD SDHB FLT4
30 hemangioma of liver 10.2 VHL CD34
31 multiple endocrine neoplasia 10.2 VHL SDHB NF1
32 bone squamous cell carcinoma 10.2 KDR ENG
33 arteriovenous malformations of the brain 10.2 VEGFA RASA1 KDR ENG ACVRL1
34 multiple endocrine neoplasia, type iia 10.2 SDHD SDHB NF1
35 cerebrum cancer 10.2 VEGFA NF1 KDR
36 supratentorial cancer 10.2 VEGFA NF1 KDR
37 venous malformations, multiple cutaneous and mucosal 10.2 RASA1 GLMN FLT4 ACVRL1
38 hobnail hemangioma 10.2 FLT4 CD34
39 benign perivascular tumor 10.2 SLC2A1 GLMN CD34
40 connective tissue cancer 10.1 VEGFA SERPINA3 CD34
41 sporadic pheochromocytoma 10.1 VHL SDHD SDHB NF1
42 pheochromocytoma 10.1 VHL SDHD SDHB NF1
43 deep angioma 10.1 SLC2A1 CD34
44 paraganglioma 10.1 VHL SDHD SDHB NF1
45 lymphangioma 10.1 VEGFA PROX1 KDR FLT4
46 autosomal genetic disease 10.1 VEGFA SDHD SDHB NF1
47 malignant epithelioid hemangioendothelioma 10.1 KDR FLT4 CD34
48 gastrointestinal system cancer 10.0 VEGFA KDR CD34
49 malignant hemangioma 10.0 KDR FLT4 CD34
50 interstitial emphysema 10.0 PROX1 FLT4 CD34

Graphical network of the top 20 diseases related to Cardiovascular Organ Benign Neoplasm:



Diseases related to Cardiovascular Organ Benign Neoplasm

Symptoms & Phenotypes for Cardiovascular Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.19 ACVRL1 KDR NF1 SDHD VHL
2 Decreased viability GR00221-A-2 10.19 ACVRL1 KDR NF1 SDHD VHL FLT4
3 Decreased viability GR00221-A-3 10.19 ACVRL1 KDR RASA1
4 Decreased viability GR00221-A-4 10.19 ACVRL1 KDR NF1 SDHD RASA1
5 Decreased viability GR00301-A 10.19 VHL
6 Decreased viability GR00342-S-1 10.19 FLT4
7 Decreased viability GR00342-S-2 10.19 FLT4
8 Decreased viability GR00342-S-3 10.19 FLT4
9 Decreased viability GR00381-A-1 10.19 SDHD RASA1
10 Decreased viability GR00402-S-2 10.19 ACVRL1 KDR NF1 SDHD VHL RASA1
11 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 NF1 VHL

MGI Mouse Phenotypes related to Cardiovascular Organ Benign Neoplasm:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 ACVRL1 CD2AP ENG FLT4 GLA GLMN
2 homeostasis/metabolism MP:0005376 10.38 ACVRL1 CD2AP CD34 ENG FLT4 GLA
3 cellular MP:0005384 10.37 ARHGAP32 CD34 GLA GLMN KDR NF1
4 growth/size/body region MP:0005378 10.36 ACVRL1 CD2AP ENG FLT4 GLA GLMN
5 mortality/aging MP:0010768 10.28 ACVRL1 CD2AP ENG FLT4 GLA GLMN
6 behavior/neurological MP:0005386 10.27 ACVRL1 ARHGAP32 ENG GLA KDR NF1
7 hematopoietic system MP:0005397 10.27 ACVRL1 CD2AP CD34 ENG KDR NF1
8 embryo MP:0005380 10.26 ACVRL1 ENG FLT4 GLMN KDR NF1
9 immune system MP:0005387 10.2 CD2AP CD34 FLT4 GLA KDR NF1
10 digestive/alimentary MP:0005381 10.19 ACVRL1 ENG FLT4 NF1 PECAM1 PROX1
11 muscle MP:0005369 10.11 ACVRL1 ENG FLT4 GLA KDR NF1
12 craniofacial MP:0005382 10.09 ACVRL1 ENG KDR NF1 RASA1 VEGFA
13 liver/biliary system MP:0005370 10.09 ACVRL1 FLT4 GLA KDR NF1 PECAM1
14 nervous system MP:0003631 10.03 ACVRL1 ARHGAP32 ENG GLA GLMN KDR
15 normal MP:0002873 9.85 ACVRL1 ENG FLT4 KDR NF1 PROX1
16 neoplasm MP:0002006 9.8 CD34 NF1 SDHB SDHD VEGFA VHL
17 renal/urinary system MP:0005367 9.56 ACVRL1 CD2AP GLA NF1 PECAM1 SDHB
18 respiratory system MP:0005388 9.17 ACVRL1 ENG KDR NF1 PECAM1 PROX1

Drugs & Therapeutics for Cardiovascular Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cardiovascular Organ Benign Neoplasm

Genetic Tests for Cardiovascular Organ Benign Neoplasm

Anatomical Context for Cardiovascular Organ Benign Neoplasm

MalaCards organs/tissues related to Cardiovascular Organ Benign Neoplasm:

41
Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Cardiovascular Organ Benign Neoplasm:

19
Blood

Publications for Cardiovascular Organ Benign Neoplasm

Variations for Cardiovascular Organ Benign Neoplasm

Expression for Cardiovascular Organ Benign Neoplasm

Search GEO for disease gene expression data for Cardiovascular Organ Benign Neoplasm.

Pathways for Cardiovascular Organ Benign Neoplasm

Pathways related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1 12.62 VHL VEGFA SLC2A1 FLT4 ELOB
2 12.52 VEGFA RASA1 NF1 KDR FLT4
3
Show member pathways
12.45 VEGFA RASA1 NF1 KDR FLT4
4
Show member pathways
12.37 VHL VEGFA SLC2A1 ELOB
5
Show member pathways
12.17 VEGFA RASA1 NF1 KDR
6
Show member pathways
11.78 VEGFA RASA1 KDR
7 11.66 VHL VEGFA SLC2A1 ELOB
8 11.5 PROX1 PECAM1 KDR FLT4 ENG
9 11.42 VEGFA SLC2A1 ENG
10
Show member pathways
11.4 VHL VEGFA RASA1 KDR FLT4 CD2AP
11 11.29 VHL VEGFA SLC2A1 ELOB
12 11.18 VEGFA KDR FLT4
13 10.77 VHL VEGFA
14 10.7 VHL ELOB
15 10.55 VHL VEGFA SLC2A1 KDR ELOB

GO Terms for Cardiovascular Organ Benign Neoplasm

Cellular components related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.46 KDR FLT4 ENG ACVRL1
2 Cul2-RING ubiquitin ligase complex GO:0031462 9.32 GLMN ELOB
3 VCB complex GO:0030891 8.96 VHL ELOB
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHD SDHB
5 cytoplasm GO:0005737 10.1 VHL VEGFA SLC2A1 RASA1 PROX1 PECAM1

Biological processes related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.91 VEGFA KDR FLT4 ENG
2 response to hypoxia GO:0001666 9.87 VEGFA SLC2A1 NF1 ACVRL1
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.79 VEGFA KDR FLT4
4 positive regulation of angiogenesis GO:0045766 9.77 VEGFA KDR ENG CD34 ACVRL1
5 negative regulation of gene expression GO:0010629 9.73 VHL VEGFA KDR ENG CD34 ACVRL1
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.7 VEGFA KDR FLT4
7 sprouting angiogenesis GO:0002040 9.69 VEGFA FLT4 ENG
8 blood vessel morphogenesis GO:0048514 9.67 RASA1 FLT4 ACVRL1
9 negative regulation of nitric oxide biosynthetic process GO:0045019 9.66 GLA CD34
10 endocardial cushion morphogenesis GO:0003203 9.65 ENG ACVRL1
11 positive regulation of positive chemotaxis GO:0050927 9.65 VEGFA KDR
12 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.65 VHL VEGFA ELOB
13 lymph vessel development GO:0001945 9.64 PROX1 FLT4
14 smooth muscle tissue development GO:0048745 9.64 NF1 ENG
15 positive regulation of vasculogenesis GO:2001214 9.63 KDR CD34
16 positive regulation of protein kinase C signaling GO:0090037 9.63 VEGFA FLT4
17 artery morphogenesis GO:0048844 9.63 VEGFA NF1 ENG
18 angiogenesis GO:0001525 9.63 VEGFA PECAM1 KDR FLT4 ENG ACVRL1
19 dorsal aorta morphogenesis GO:0035912 9.62 ENG ACVRL1
20 positive regulation of endothelial cell migration GO:0010595 9.62 VEGFA PROX1 KDR FLT4
21 venous blood vessel morphogenesis GO:0048845 9.61 PROX1 ENG
22 vascular endothelial growth factor signaling pathway GO:0038084 9.61 VEGFA KDR FLT4
23 regulation of blood vessel endothelial cell migration GO:0043535 9.6 NF1 ACVRL1
24 lymphatic endothelial cell differentiation GO:0060836 9.59 PROX1 ACVRL1
25 endothelium development GO:0003158 9.58 KDR CD34
26 atrial cardiac muscle tissue morphogenesis GO:0055009 9.58 PROX1 ENG
27 lymphangiogenesis GO:0001946 9.58 PROX1 FLT4 ACVRL1
28 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.56 VEGFA KDR
29 glomerular endothelium development GO:0072011 9.55 PECAM1 CD34
30 endocardial cushion to mesenchymal transition GO:0090500 9.54 ENG ACVRL1
31 vasculogenesis GO:0001570 9.35 VEGFA RASA1 KDR GLMN ENG
32 positive regulation of endothelial cell proliferation GO:0001938 9.1 VEGFA PROX1 NF1 KDR FLT4 ACVRL1
33 negative regulation of apoptotic process GO:0043066 10.05 VHL VEGFA RASA1 KDR FLT4

Molecular functions related to Cardiovascular Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 VHL VEGFA SLC2A1 SERPINA3 SDHB RASA1
2 activin binding GO:0048185 9.4 ENG ACVRL1
3 ubiquinone binding GO:0048039 9.37 SDHD SDHB
4 growth factor binding GO:0019838 9.33 KDR FLT4 ACVRL1
5 vascular endothelial growth factor-activated receptor activity GO:0005021 9.32 KDR FLT4
6 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.26 SDHD SDHB
7 vascular endothelial growth factor receptor binding GO:0005172 8.96 VEGFA CD2AP

Sources for Cardiovascular Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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