MCID: CRD006
MIFTS: 22

Cardiovascular Syphilis

Categories: Cardiovascular diseases, Infectious diseases

Aliases & Classifications for Cardiovascular Syphilis

Summaries for Cardiovascular Syphilis

Disease Ontology : 12 A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

MalaCards based summary : Cardiovascular Syphilis, also known as syphilis, cardiovascular, is related to syphilis and aortic valve insufficiency, and has symptoms including syphilitic chancre An important gene associated with Cardiovascular Syphilis is DDX41 (DEAD-Box Helicase 41). Affiliated tissues include heart, and related phenotype is Increased viability with MLN4924 (a NAE inhibitor).

Related Diseases for Cardiovascular Syphilis

Diseases related to Cardiovascular Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 syphilis 10.8
2 aortic valve insufficiency 10.0
3 aortitis 9.9
4 atrial standstill 1 9.8
5 myocardial infarction 9.8
6 acute myocardial infarction 9.8
7 coronary stenosis 9.8
8 human immunodeficiency virus infectious disease 9.8
9 amyloidosis 9.8
10 neurosyphilis 9.8
11 eumycotic mycetoma 9.7 DDX41 SMUG1

Graphical network of the top 20 diseases related to Cardiovascular Syphilis:



Diseases related to Cardiovascular Syphilis

Symptoms & Phenotypes for Cardiovascular Syphilis

UMLS symptoms related to Cardiovascular Syphilis:


syphilitic chancre

GenomeRNAi Phenotypes related to Cardiovascular Syphilis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.62 DDX41 SMUG1

Drugs & Therapeutics for Cardiovascular Syphilis

Search Clinical Trials , NIH Clinical Center for Cardiovascular Syphilis

Genetic Tests for Cardiovascular Syphilis

Anatomical Context for Cardiovascular Syphilis

MalaCards organs/tissues related to Cardiovascular Syphilis:

41
Heart

Publications for Cardiovascular Syphilis

Articles related to Cardiovascular Syphilis:

(show top 50) (show all 99)
# Title Authors Year
1
Cardiovascular syphilis: down but not out! ( 29608710 )
2018
2
Asymptomatic Cardiovascular Syphilis With Aortic Regurgitation Requiring Surgical Repair in an HIV-Infected Patient. ( 29181418 )
2017
3
A case of acute myocardial infarction due to cardiovascular syphilis with aortic regurgitation and bilateral coronary ostial stenosis. ( 27873284 )
2016
4
Cardiovascular syphilis complicated by Lower thoracic and upper abdominal aneurysm - A rare case report. ( 27190418 )
2016
5
Cardiovascular syphilis with coronary stenosis and aneurysm. ( 25634420 )
2014
6
Bilateral coronary ostial stenosis with bilateral renal ostial stenosis in cardiovascular syphilis: de novo percutaneous coronary intervention and in-stent restenosis. ( 23386712 )
2013
7
Bilateral Coronary Ostial Lesions in Cardiovascular Syphilis Treated by Means of Percutaneous Coronary Stenting. ( 24391345 )
2013
8
Bilateral coronary ostial stenosis and aortic regurgitation in a patient with cardiovascular syphilis. ( 30533099 )
2012
9
Identifying cardiovascular syphilis at operation. ( 19932797 )
2009
10
Full blown cardiovascular syphilis with aneurysm of the innominate artery. ( 19932798 )
2009
11
Cardiovascular syphilis. ( 19068539 )
2008
12
A pox on the heart: five cases of cardiovascular syphilis. ( 16515437 )
2006
13
Cardiovascular syphilis in HIV infection: a case-control study at the Institute of Sexually Transmitted Diseases, Chennai, India. ( 16061553 )
2005
14
Cardiovascular syphilis: a rare medical diagnosis? ( 9860218 )
1998
15
Aortic dissection and cardiovascular syphilis: report of an observation with transesophageal echocardiography and anatomopathologic findings. ( 7917353 )
1994
16
Clinically isolated left coronary ostial stenosis: a manifestation of cardiovascular syphilis--case history. ( 8239065 )
1993
17
Cardiovascular syphilis. ( 2679075 )
1989
18
"Late" manifestations of cardiovascular syphilis occurring in a young man. ( 3676028 )
1987
19
Treatment of cardiovascular syphilis. ( 1010781 )
1976
20
Late complications of syphilis. A comparative epidemiological and serological study of cardiovascular syphilis and various forms of neurosyphilis. ( 4184283 )
1969
21
Cardiovascular syphilis with amyloidosis and periods of alternating heart block. ( 5829772 )
1965
22
Cardiovascular syphilis today. ( 13974629 )
1963
23
Present status of the management of cardiovascular syphilis. ( 13843327 )
1960
24
Trends in cardiovascular syphilis. ( 13411901 )
1957
25
Therapeutic paradox in cardiovascular syphilis. ( 13419070 )
1957
26
Observations on penicillin therapy in cardiovascular syphilis. ( 13508112 )
1957
27
Cardiovascular syphilis in neurosyphilitic patients. ( 13497510 )
1957
28
PROGNOSIS of cardiovascular syphilis. ( 13320906 )
1956
29
Follow-up studies in cardiovascular syphilis. ( 14352084 )
1955
30
Failure of adequate treatment in preventing cardiovascular syphilis. ( 14386175 )
1955
31
Cardiovascular syphilis; a clinical study of 578 cases. ( 14389702 )
1955
32
Prognosis of cardiovascular syphilis. ( 13294587 )
1955
33
Cardiovascular syphilis. ( 14367862 )
1955
34
The penicillin treatment of cardiovascular syphilis. ( 13303129 )
1955
35
Penicillin treatment of cardiovascular syphilis. ( 13202694 )
1954
36
Cardiovascular syphilis; analysis of 43 cases. ( 13149638 )
1954
37
Ambulatory treatment of cardiovascular syphilis with penicillin. ( 13040644 )
1953
38
Studies in cardiovascular syphilis. III. The natural history of syphilitic aortic insufficiency. ( 13065608 )
1953
39
Studies in cardiovascular syphilis. III. The natural history of syphilitic aortic insufficiency. ( 13057821 )
1953
40
Cardiovascular syphilis in a general medical clinic. ( 13047504 )
1953
41
Observations on the penicillin treatment of cardiovascular syphilis. II. Complicated aortitis. ( 13080554 )
1953
42
Observations on penicillin-treated cardiovascular syphilis. I. Uncomplicated aortitis. ( 13080553 )
1953
43
Penicillin treatment of cardiovascular syphilis. ( 13032412 )
1953
44
STATUS of penicillin therapy in cardiovascular syphilis. ( 24542628 )
1953
45
Penicillin treatment of cardiovascular syphilis. ( 12976390 )
1952
46
Cardiovascular syphilis; report of five cases. ( 14938689 )
1952
47
Studies in cardiovascular syphilis. II. Methodologic problems in the evaluation of therapy. ( 14903417 )
1952
48
Treatment of cardiovascular syphilis. ( 14957681 )
1952
49
Stethograms in cardiovascular syphilis as an aid for early diagnosis. ( 14952680 )
1952
50
Further observations on penicillin-treated cardiovascular syphilis. ( 14936223 )
1952

Variations for Cardiovascular Syphilis

Expression for Cardiovascular Syphilis

Search GEO for disease gene expression data for Cardiovascular Syphilis.

Pathways for Cardiovascular Syphilis

GO Terms for Cardiovascular Syphilis

Sources for Cardiovascular Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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