MCID: CRD006
MIFTS: 25

Cardiovascular Syphilis

Categories: Cardiovascular diseases, Infectious diseases

Aliases & Classifications for Cardiovascular Syphilis

Summaries for Cardiovascular Syphilis

Disease Ontology : 12 A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

MalaCards based summary : Cardiovascular Syphilis, also known as syphilis, cardiovascular, is related to syphilis and tertiary syphilis, and has symptoms including syphilitic chancre An important gene associated with Cardiovascular Syphilis is TRO (Trophinin). Affiliated tissues include heart and testes, and related phenotypes are Decreased hepcidin::fluc mRNA expression and Increased viability with MLN4924 (a NAE inhibitor)

Related Diseases for Cardiovascular Syphilis

Graphical network of the top 20 diseases related to Cardiovascular Syphilis:



Diseases related to Cardiovascular Syphilis

Symptoms & Phenotypes for Cardiovascular Syphilis

UMLS symptoms related to Cardiovascular Syphilis:


syphilitic chancre

GenomeRNAi Phenotypes related to Cardiovascular Syphilis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased hepcidin::fluc mRNA expression GR00253-A 9.26 C19orf33 DDX41 MS4A2 TRO
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.8 DDX41 KAT8 TPR

Drugs & Therapeutics for Cardiovascular Syphilis

Search Clinical Trials , NIH Clinical Center for Cardiovascular Syphilis

Genetic Tests for Cardiovascular Syphilis

Anatomical Context for Cardiovascular Syphilis

MalaCards organs/tissues related to Cardiovascular Syphilis:

40
Heart, Testes

Publications for Cardiovascular Syphilis

Articles related to Cardiovascular Syphilis:

(show top 50) (show all 192)
# Title Authors PMID Year
1
Trends in Deaths Due to Syphilis, United States, 1968-2015. 61
30044338 2019
2
Syphilitic aortitis and its complications in the modern era. 61
27982548 2018
3
Syphilis-Cardiovascular Manifestations of the Great Imitator. 61
29193072 2018
4
Cardiovascular syphilis: down but not out! 61
29608710 2018
5
Syphilitic Aortitis Diagnosis in Clinical Setting. 61
29701397 2017
6
Asymptomatic Cardiovascular Syphilis With Aortic Regurgitation Requiring Surgical Repair in an HIV-Infected Patient. 61
29181418 2017
7
Aortic aneurysm in a patient with syphilis-related spinal pain and paraplegia. 61
28769140 2017
8
A case of acute myocardial infarction due to cardiovascular syphilis with aortic regurgitation and bilateral coronary ostial stenosis. 61
27873284 2016
9
Syphilis: Re-emergence of an old foe. 61
28357375 2016
10
A case of syphilitic aortic aneurysm with sternal erosion and impending rupture. 61
25344618 2016
11
Syphilitic aortic aneurysm with a pulmonary lesion: a case report and literature view. 61
27777861 2016
12
Cardiovascular syphilis complicated by Lower thoracic and upper abdominal aneurysm - A rare case report. 61
27190418 2016
13
Management of Adult Syphilis: Key Questions to Inform the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. 61
26602620 2015
14
Rare presentation of ruptured syphilitic aortic aneurysm with pseudoaneurysm. 61
26481180 2015
15
Cardiovascular syphilis with coronary stenosis and aneurysm. 61
25634420 2014
16
Bilateral coronary ostial stenosis secondary to syphilitic aortitis. 61
25151925 2014
17
[Bilateral coronary artery ostial stenosis in a patient with cardiovascular syphilis]. 61
25327606 2014
18
Bilateral coronary ostial stenosis with bilateral renal ostial stenosis in cardiovascular syphilis: de novo percutaneous coronary intervention and in-stent restenosis. 61
23386712 2013
19
Bilateral coronary ostial lesions in cardiovascular syphilis treated by means of percutaneous coronary stenting. 61
24391345 2013
20
Bilateral coronary ostial stenosis and aortic regurgitation in a patient with cardiovascular syphilis. 61
30533099 2012
21
[Syphilitic mesaortitis]. 61
22567947 2012
22
Chronic syphilitic aortic aneurysm complicated with chronic aortic dissection. 61
20864080 2010
23
Identifying cardiovascular syphilis at operation. 61
19932797 2009
24
Full blown cardiovascular syphilis with aneurysm of the innominate artery. 61
19932798 2009
25
Natural history of syphilitic aortitis. 61
19932796 2009
26
Syphilitic aortitis: an uncommon cause of acquired aortopulmonary fistula. 61
19853135 2009
27
Cardiovascular syphilis. 61
19068539 2008
28
[Bilateral ostial coronary lesion in cardiovascular syphilis: case report]. 61
18719841 2008
29
[Cardiovascular syphilis: diagnosis, treatment]. 61
17469346 2006
30
Surgical repair of a syphilitic aneurysm of the distal arch and descending aorta. 61
16551824 2006
31
A pox on the heart: five cases of cardiovascular syphilis. 61
16515437 2006
32
Aortitis diagnosed by F-18-fluorodeoxyglucose positron emission tomography in a patient with syphilis and HIV coinfection. 61
16258874 2005
33
Cardiovascular syphilis in HIV infection: a case-control study at the Institute of Sexually Transmitted Diseases, Chennai, India. 61
16061553 2005
34
The often overlooked digital tuft: clues to diagnosis and pathophysiology of neuropathic disease and spondyloarthropathy. 61
15647437 2005
35
Penetrating ulcer of ascending thoracic aorta in syphilis. 61
14696153 2004
36
Syphilitic aneurysm: case report. 61
14670221 2003
37
[Cardiovascular syphilis: a case report]. 61
11171490 2000
38
Isolated bilateral ostial coronary stenosis with proximal right coronary artery occlusion. 61
12470387 2000
39
[Lipiodol therapeutic indications from 1901 to 1930]. 61
11625682 2000
40
Cardiovascular syphilis: a rare medical diagnosis? 61
9860218 1998
41
Periodic syphilis profile in a New Delhi hospital. 61
10093420 1998
42
An unusual aorto-pulmonary communication secondary to syphilitic aortitis. 61
9431867 1997
43
Paraparesis due to syphilitic aortic dissection. 61
9008521 1997
44
[Aneurysm of the descending thoracic aorta in tertiary syphilis]. 61
7725781 1995
45
[The involvement of the cardiovascular system in syphilis]. 61
7791298 1995
46
Aortic dissection and cardiovascular syphilis: report of an observation with transesophageal echocardiography and anatomopathologic findings. 61
7917353 1994
47
Diagnosis of congenital syphilis in adults presenting with interstitial keratitis. 61
8069759 1994
48
[A case of ruptured left ventricular aneurysm due to syphilitic myocarditis]. 61
8138705 1994
49
Clinically isolated left coronary ostial stenosis: a manifestation of cardiovascular syphilis--case history. 61
8239065 1993
50
[Cardiovascular syphilis. Report of 2 cases]. 61
8512731 1993

Variations for Cardiovascular Syphilis

Expression for Cardiovascular Syphilis

Search GEO for disease gene expression data for Cardiovascular Syphilis.

Pathways for Cardiovascular Syphilis

GO Terms for Cardiovascular Syphilis

Cellular components related to Cardiovascular Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinetochore GO:0000776 8.62 TPR KAT8

Sources for Cardiovascular Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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