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MCID: CRD246
MIFTS: 57

Cardiovascular System Disease

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cardiovascular System Disease

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MalaCards integrated aliases for Cardiovascular System Disease:

Name: Cardiovascular System Disease 12 15
Disease of Subdivision of Hemolymphoid System 12
Abnormality of the Cardiovascular System 30
Disorder of Cardiovascular System 30
Cardiovascular Diseases 45
Cardiovascular Disease 17

Classifications:

MalaCards categories:
Global: Fetal diseases
Anatomical: Cardiovascular diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1287
ICD9CM 36 429.2
MeSH 45 D002318
NCIt 51 C2931
SNOMED-CT 69 49601007
ICD10 34 I51.6 P29.9
UMLS 74 C0007222
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Summaries for Cardiovascular System Disease

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Disease Ontology : 12 A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.

MalaCards based summary : Cardiovascular System Disease, also known as disease of subdivision of hemolymphoid system, is related to diabetes mellitus and hypercholesterolemia, familial. An important gene associated with Cardiovascular System Disease is MIR210 (MicroRNA 210), and among its related pathways/superpathways are MicroRNAs in cancer and Senescence and Autophagy in Cancer. The drugs Enalapril and Rimonabant have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 77 Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD... more...

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Related Diseases for Cardiovascular System Disease

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Diseases in the Cardiovascular System Disease family:

Autoimmune Disease of Cardiovascular System

Diseases related to Cardiovascular System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 609)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus 33.0 ACE ADIPOQ ALB APOA1 APOB CDKN2B-AS1
2 hypercholesterolemia, familial 32.9 ACE APOA1 APOB CRP INS NOS3
3 glucose intolerance 32.9 ADIPOQ APOB CRP INS
4 coronary heart disease 1 32.8 ACE ADIPOQ APOA1 APOB CDKN2B-AS1 CRP
5 heart valve disease 32.7 ACE CRP REN
6 heart disease 32.4 ACE ALB APOA1 APOB CRP IL6
7 vascular disease 32.4 ACE ADIPOQ ALB APOA1 APOB CRP
8 abdominal obesity-metabolic syndrome 1 32.3 ADIPOQ INS SERPINE1
9 prediabetes syndrome 32.3 ADIPOQ ALB APOB CRP IL6 INS
10 kidney disease 31.8 ACE ADIPOQ ALB CRP IL6 INS
11 lipid metabolism disorder 31.8 ACE ADIPOQ APOA1 APOB CRP INS
12 chronic kidney failure 31.8 ACE ADIPOQ ALB APOB CRP IL6
13 diabetes mellitus, noninsulin-dependent 31.7 ACE ADIPOQ ALB APOA1 APOB CDKN2B-AS1
14 sleep apnea 31.6 ACE ADIPOQ CRP IL6 INS NOS3
15 atherosclerosis susceptibility 31.6 ADIPOQ APOA1 APOB CDKN2B-AS1 CRP IL6
16 liver disease 31.5 ADIPOQ ALB IL6 INS
17 hyperuricemia 31.5 APOB CRP INS REN
18 end stage renal failure 31.4 ACE ALB APOB CRP IL6
19 myocardial infarction 31.4 ACE ADIPOQ ALB APOA1 APOB CDKN2B-AS1
20 pre-eclampsia 31.4 ADIPOQ IL6 NOS3 REN SERPINE1
21 periodontitis 31.3 CDKN2B-AS1 CRP IL6
22 homocysteinemia 31.3 ALB CRP NOS3
23 arteries, anomalies of 31.3 ACE ADIPOQ ALB APOA1 APOB CRP
24 arteriosclerosis 31.3 ACE ADIPOQ APOA1 APOB CRP IL6
25 microvascular complications of diabetes 3 31.2 ACE ALB INS
26 endocarditis 31.2 ALB CRP IL6
27 apnea, obstructive sleep 31.2 ADIPOQ CRP IL6 INS REN
28 body mass index quantitative trait locus 11 31.2 ADIPOQ APOA1 APOB CRP IL6 INS
29 peripheral artery disease 31.2 ACE APOB CDKN2B-AS1 CRP IL6 NOS3
30 hyperglycemia 31.2 ADIPOQ ALB INS NOS3
31 hypertriglyceridemia, familial 31.1 APOA1 APOB INS
32 hypertension, essential 31.1 ACE ADIPOQ ALB APOA1 APOB CDKN2B-AS1
33 ischemic heart disease 31.1 ACE APOA1 APOB CRP IL6 NOS3
34 coronary artery anomaly 31.1 ACE APOA1 APOB CRP NOS3 SERPINE1
35 acute myocardial infarction 31.1 ACE APOA1 APOB CDKN2B-AS1 CRP SERPINE1
36 kawasaki disease 31.1 ALB CRP IL6
37 angina pectoris 31.0 ACE CRP IL6 NOS3
38 uremia 31.0 ALB CRP INS
39 cerebrovascular disease 31.0 ACE ADIPOQ APOA1 APOB CRP IL6
40 intermittent claudication 31.0 ACE ALB CRP IL6 SERPINE1
41 obstructive nephropathy 31.0 ACE ALB REN
42 microvascular complications of diabetes 5 30.9 ACE ALB INS NOS3 SERPINE1
43 diabetes mellitus, insulin-dependent 30.9 ACE ALB APOB IL6 INS
44 infective endocarditis 30.9 CRP IL6 SERPINE1
45 peripheral vascular disease 30.9 ACE ALB APOA1 APOB CRP IL6
46 retinal vascular disease 30.8 ACE ALB INS
47 hyperinsulinism 30.6 APOB INS SERPINE1
48 renal hypertension 30.6 ACE ALB REN
49 overnutrition 30.6 ADIPOQ APOB CRP IL6 INS SERPINE1
50 gallbladder disease 30.5 APOA1 APOB INS

Graphical network of the top 20 diseases related to Cardiovascular System Disease:



Diseases related to Cardiovascular System Disease
Sources

Symptoms & Phenotypes for Cardiovascular System Disease

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MGI Mouse Phenotypes related to Cardiovascular System Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 ACE ADIPOQ APOA1 APOB CRP IL6
2 homeostasis/metabolism MP:0005376 9.93 ACE ADIPOQ ALB APOA1 APOB CRP
3 adipose tissue MP:0005375 9.8 ACE ADIPOQ IL6 INS NOS3 SERPINE1
4 liver/biliary system MP:0005370 9.61 ACE ADIPOQ ALB APOA1 APOB IL6
5 renal/urinary system MP:0005367 9.28 ACE ADIPOQ ALB IL6 INS NOS3
Sources

Drugs & Therapeutics for Cardiovascular System Disease

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Drugs for Cardiovascular System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1324)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enalapril Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 75847-73-3 5362032 40466924
2
Rimonabant Approved, Investigational Phase 4,Phase 3,Phase 2 168273-06-1, 158681-13-1 104850
3
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 79902-63-9 54454
4
Atorvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 134523-00-5 60823
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
6
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 120202-66-6, 113665-84-2 60606
7
Enalaprilat Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 76420-72-9 6917719
8
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 24280-93-1 446541
9
Allopurinol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 315-30-0 2094
10
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
11
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137862-53-4 60846
12
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
13
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 637568 5271565
14
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 32051
15
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
16
tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1401-55-4
17
Dobutamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 34368-04-2 36811
18
leucovorin Approved Phase 4,Phase 2,Phase 3,Not Applicable 58-05-9 6006 143
19
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 11953898 15589840
20
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57-83-0 5994
21
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-28-2 5757
22
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 71-58-9
23
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 28014-46-2
24
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
25
Atenolol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 29122-68-7 2249
26
Glyburide Approved Phase 4,Phase 3 10238-21-8 3488
27
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
28
Gliclazide Approved Phase 4,Phase 3,Phase 2 21187-98-4 3475
29
Glimepiride Approved Phase 4,Phase 3,Not Applicable 93479-97-1 3476
30
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 111025-46-8 4829
31
Norethindrone Approved Phase 4 68-22-4 6230
32
Pantoprazole Approved Phase 4 102625-70-7 4679
33
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
34
Candesartan cilexetil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 145040-37-5 2540
35
Moxonidine Approved, Investigational Phase 4,Phase 3 75438-57-2 4810
36
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 1 73963-72-1 2754
37
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-93-5 3639
38
Trimetazidine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 5011-34-7
39
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 10102-43-9 145068
40
Isosorbide Dinitrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 87-33-2 6883
41
AT-101 Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90141-22-3, 652-67-5 12597
42
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
43
Acarbose Approved, Investigational Phase 4,Phase 3 56180-94-0 441184
44
Amlodipine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 88150-42-9 2162
45
Chitosan Approved Phase 4 9012-76-4 71853
46
Curcumin Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 458-37-7 969516
47
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 142387-99-3, 95635-55-5 56959
48
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Not Applicable 274693-27-5 9871419
49
Methyltestosterone Approved Phase 4,Phase 2,Phase 3,Not Applicable 58-18-4 6010
50
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 5949-44-0

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases. Unknown status NCT00734123 Phase 4 Simvastatin or Atorvastatin;Enalapril;Aspirin or clopidogrel;Rimonabant
2 Vitamin D and Inflammatory Markers of Cardiovascular Disease in African Americans With Type 2 Diabetes Unknown status NCT01153243 Phase 4 Ergocalciferol;Placebo pill
3 Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients Unknown status NCT00247494 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
4 Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines Unknown status NCT02797028 Phase 4 Allopurinol
5 Living With Statins - Interventional Exercise Study Unknown status NCT02796378 Phase 4 Training+Simvastatin+Q10-placebo;Training+Simvastatin-placebo+Q10-placebo;Training+Simvastatin+Q10
6 A Morbidity-Mortality and Remodeling Study With Valsartan Unknown status NCT00133328 Phase 4 valsartan
7 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4 Adalimumab treatment arm;Fumaric acid esters treatment group
8 Multifactorial Intervention in Type 2 Diabetes - Italy Unknown status NCT01240070 Phase 4
9 PPARGC1β and CNTN4 Genotype Aspirin Study Unknown status NCT02970604 Phase 4 Aspirin
10 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
11 Levosimendan Versus Dobutamine in Cardiopatic Patients Undergoing Major Non Cardiac Surgery Unknown status NCT02012946 Phase 4 Levosimendan;Dobutamine
12 Xanthine Oxidase Inhibition in Renal Transplant Recipients Unknown status NCT01332799 Phase 4 allopurinol or placebo
13 Homocysteine Lowering and Atherosclerosis Reduction Trial (HART) Unknown status NCT00217178 Phase 4 Vitamins: Folic acid, B6, B12
14 Multi-centre Clinical Trial on Hormone Replacement Treatment in China Unknown status NCT01698164 Phase 4 estradiol plus MPA;Ximingting Tablet;estradiol plus progesterone
15 Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina. Unknown status NCT01397994 Phase 4 Nicorandil;Atenolol
16 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
17 Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial Unknown status NCT00700856 Phase 4 add-on pioglitazone;add-on sulphonylurea
18 HOPE-2 Study (Heart Outcomes Prevention Evaluation-2 Study) Unknown status NCT00106886 Phase 4 Folic acid, vitamin B6 and B12 or placebo
19 Oral Verses Patch Trial In Menopausal Women - Individualisation of Oestrogen Therapy Unknown status NCT02264743 Phase 4 Femoston Conti;EVOREL® CONTI
20 Hemocontrol's Effectiveness on the Reduction of Cardiovascular Long-term EventS Unknown status NCT01515878 Phase 4
21 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
22 Endothelial Dysfunction and Subclinical Atheromatosis in Chronic HCV Infection. Response to DAA Agents. Unknown status NCT02802280 Phase 4
23 Omeprazole and Pantoprazole Antiplatelet Effect of Clopidogrel Clinical Trials(OPEN) Unknown status NCT01735227 Phase 4 omeprazole;Pantoprazole
24 Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease Unknown status NCT00235287 Phase 4 Candesartan and enalapril;candesartan and enalapril;candesartan and enalapril;candesartan and enalapril
25 Investigator Initiated Randomized Open-label Comparative Study of Britomar (Prolonged Release Torasemide) and Diuver (Torasemide) to Assess Effects on Natriuresis and Central Hemodynamics. Unknown status NCT02087332 Phase 4 Prolonged release Torasemide (Britomar);Torasemide (Diuver)
26 Self-Assessment Method for Statin Side-effects Or Nocebo Unknown status NCT02668016 Phase 4 Atorvastatin
27 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
28 Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity Unknown status NCT01180231 Phase 4 Moxonidine (Physiotens)
29 Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients Unknown status NCT02933788 Phase 4 Cilostazol;Acetylsalicylic acid
30 Treatment of HYpertension: Morning Versus Evening Unknown status NCT02214498 Phase 4 Enalapril/hydrochlorothiazide;Placebo
31 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4 Vitamin D3
32 Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization Unknown status NCT03072121 Phase 4 Shexiang Baoxin pill;SBP placebo;Aspirin Enteric-coated Tablets;Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet;Atorvastatin Calcium;Isosorbide Mononitrate Tab 20 MG;Metoprolol Tartrate Tab 25 MG;Trimetazidine Dihydrochloride Tablets
33 Curative Effect Evaluation of Danlou Tablet on Coronary Artery Disease Not Amenable to Revascularization Unknown status NCT03072082 Phase 4 Danlou Tablet;DanLou Tablet placebo;Aspirin Enteric-coated Tablets;Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet;Atorvastatin calcium;Isosorbide Mononitrate Tab 20 MG;Metoprolol Tartrate Tab 25 MG;Trimetazidine Dihydrochloride Tablets
34 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
35 Feasibility Study of the Intensive Systolic Blood Pressure Control Unknown status NCT02817503 Phase 4 Standard BP control;Moderate BP control;Intensive BP control
36 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
37 Hemostasis Pad Using Chitosan After Invasive Percutaneous Procedures Unknown status NCT02954029 Phase 4
38 Ivabradine in Hemodialysed Patients With Increased Heart Rate Unknown status NCT01364077 Phase 4 Ivabradine;Placebo
39 Curcumin for Type 2 Diabetic Patients Unknown status NCT01052597 Phase 4 curcumin
40 Effect of Rosuvastatin Therapy on HDL2 Level Unknown status NCT02593487 Phase 4 Rosuvastatin 10mg/d group;Rosuvastatin 20mg/d group
41 Ranolazine a Potential New Therapeutic Application Unknown status NCT02687269 Phase 4 Ranolazine;Placebo
42 GRK4 Polymorphisms Blood Pressure Response to Candesartan Unknown status NCT01629225 Phase 4 Candesartan
43 Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Stable Angina, NSTEMI and STEMI Undergoing PCI Unknown status NCT02012140 Phase 4 ticagrelor
44 Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina Unknown status NCT00131183 Phase 4 Nebido
45 Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine Unknown status NCT00564057 Phase 4 candesartan;lercanidipine
46 Metformin Induces a Dietary Restriction-like State in Human Unknown status NCT02745886 Phase 4 metformin 0.85 twice daily for 6 months
47 Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy Unknown status NCT00879060 Phase 4 spironolactone
48 Lovaza Mechanisms of Action Unknown status NCT01301794 Phase 4
49 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
50 Anti-proteinuric Effect of Calcitriol in Non-diabetic Kidney Disease Patients Unknown status NCT01512862 Phase 4 Calcitriol;Placebo

Search NIH Clinical Center for Cardiovascular System Disease

Cochrane evidence based reviews: cardiovascular diseases

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Genetic Tests for Cardiovascular System Disease

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Genetic tests related to Cardiovascular System Disease:

# Genetic test Affiliating Genes
1 Disorder of Cardiovascular System 30 ACE
2 Abnormality of the Cardiovascular System 30
Sources

Anatomical Context for Cardiovascular System Disease

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MalaCards organs/tissues related to Cardiovascular System Disease:

42
Heart, Endothelial, Kidney, Testes, Bone, Lung, Ovary
Sources

Publications for Cardiovascular System Disease

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Articles related to Cardiovascular System Disease:

# Title Authors Year
1
Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. ( 27138523 )
2016
2
Cardiovascular system disease in youth patients with various forms of glucose metabolism impairment - diagnosis and treatment. ( 18577344 )
2008