Cardiovascular System Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRD246 MIFTS: 56	Cardiovascular System Disease Categories: Blood diseases, Cardiovascular diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Cardiovascular System Disease

MalaCards integrated aliases for Cardiovascular System Disease:

Name: Cardiovascular System Disease ¹² ¹⁵

Disease of Subdivision of Hemolymphoid System ¹²

Abnormality of the Cardiovascular System ²⁹

Disorder of Cardiovascular System ²⁹

Cardiovascular Diseases ⁴³

Cardiovascular Disease ¹⁷

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Immune diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the circulatory system

Other forms of heart disease

Complications and ill-defined descriptions of heart disease

Cardiovascular disease, unspecified

External Ids:

Disease Ontology ¹² DOID:1287

ICD9CM ³⁴ 429.2

MeSH ⁴³ D002318

NCIt ⁴⁹ C2931

SNOMED-CT ⁶⁷ 49601007

ICD10 ³² I51.6

EFO ¹⁷ EFO_0000319

UMLS ⁷¹ C0007222

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Summaries for Cardiovascular System Disease

Disease Ontology : ¹² A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.

MalaCards based summary : Cardiovascular System Disease, also known as disease of subdivision of hemolymphoid system, is related to coronary heart disease 1 and vascular disease. An important gene associated with Cardiovascular System Disease is MIR210 (MicroRNA 210), and among its related pathways/superpathways are Adipogenesis and Folate Metabolism. The drugs Dimethyl fumarate and Tranexamic Acid have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related phenotypes are cardiovascular system and liver/biliary system

Wikipedia : ⁷⁴ Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD... more...

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Related Diseases for Cardiovascular System Disease

Diseases in the Cardiovascular System Disease family:

Autoimmune Disease of Cardiovascular System

Diseases related to Cardiovascular System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1276)

#	Related Disease	Score	Top Affiliating Genes
1	coronary heart disease 1	34.4	SERPINE1 NOS3 MIR145 INS IL6 EDN1
2	vascular disease	34.1	SERPINE1 REN NOS3 MIR145 MIR143 INS
3	familial hypercholesterolemia	34.1	NOS3 INS IL6 CRP APOB APOA1
4	non-alcoholic fatty liver disease	33.9	SERPINE1 INS IL6 CRP APOB APOA1
5	heart valve disease	33.7	REN EDN1 CRP ALB ACE
6	tangier disease	33.6	APOB APOA1 ALB
7	abdominal obesity-metabolic syndrome 1	33.6	SERPINE1 NOS3 INS APOB ADIPOQ
8	hyperthyroidism	33.5	REN INS CRP ALB
9	hyperlipidemia, familial combined, 3	33.5	INS APOB APOA1 ADIPOQ
10	arteriolosclerosis	33.4	REN ALB ADIPOQ
11	lipid metabolism disorder	33.3	SERPINE1 INS IL6 CRP APOB APOA1
12	chronic kidney disease	33.3	SERPINE1 REN NOS3 INS IL6 EDN1
13	pericardium disease	33.2	REN IL6 CRP ALB ACE
14	heart conduction disease	33.2	REN INS CRP ALB ACE
15	kidney disease	33.2	SERPINE1 REN NOS3 INS IL6 EDN1
16	atherosclerosis susceptibility	33.2	SERPINE1 NOS3 INS IL6 EDN1 CRP
17	prediabetes syndrome	33.1	INS IL6 CRP APOB ALB ADIPOQ
18	peripheral vascular disease	33.1	SERPINE1 NOS3 INS IL6 CRP APOB
19	cerebrovascular disease	33.1	SERPINE1 REN INS IL6 CRP APOB
20	hypercholesterolemia, familial, 1	33.1	NOS3 INS CRP APOB APOA1 ACE
21	congestive heart failure	33.1	REN NOS3 INS IL6 EDN1 CRP
22	myocardial infarction	33.1	SERPINE1 REN NOS3 MIR210 INS IL6
23	hypertension, essential	33.0	SERPINE1 REN NOS3 MIR210 MIR143 INS
24	body mass index quantitative trait locus 11	33.0	SERPINE1 REN NOS3 MIR143 INS IL6
25	sleep apnea	32.9	REN NOS3 INS IL6 EDN1 CRP
26	heart disease	32.8	SERPINE1 REN NOS3 MIR210 INS IL6
27	pre-eclampsia	32.8	SERPINE1 REN NOS3 MIR210 INS IL6
28	angina pectoris	32.8	NOS3 INS IL6 EDN1 CRP APOA1
29	end stage renal failure	32.8	REN IL6 CRP APOB ALB ADIPOQ
30	peripheral artery disease	32.8	NOS3 IL6 EDN1 CRP CDKN2B-AS1 APOB
31	hyperglycemia	32.8	SERPINE1 NOS3 INS IL6 APOB ALB
32	diabetes mellitus, noninsulin-dependent	32.7	SERPINE1 REN NOS3 INS IL6 EDN1
33	intermediate coronary syndrome	32.7	REN INS IL6 CRP APOB APOA1
34	fatty liver disease	32.6	INS IL6 CRP APOB ALB ADIPOQ
35	arteries, anomalies of	32.6	SERPINE1 REN NOS3 MIR210 MIR145 MIR143
36	pulmonary hypertension	32.6	SERPINE1 REN NOS3 IL6 EDN1 CRP
37	coronary artery anomaly	32.6	SERPINE1 NOS3 MIR145 IL6 EDN1 CRP
38	osteoporosis	32.6	SERPINE1 NOS3 INS IL6 EDN1 CRP
39	hypertriglyceridemia, familial	32.6	SERPINE1 INS APOB APOA1
40	systemic lupus erythematosus	32.6	SERPINE1 NOS3 MIR210 INS IL6 CRP
41	stroke, ischemic	32.6	SERPINE1 REN NOS3 IL6 CRP CDKN2B-AS1
42	impotence	32.5	NOS3 INS EDN1 ACE
43	aortic aneurysm	32.5	MIR145 IL6 HIF1A-AS1 CRP CDKN2B-AS1 ACE
44	hypothyroidism	32.5	SERPINE1 REN INS CRP APOB APOA1
45	microvascular complications of diabetes 3	32.4	REN MIR217 INS ALB ACE
46	pulmonary disease, chronic obstructive	32.4	INS IL6 CRP ALB ACE
47	acute myocardial infarction	32.4	SERPINE1 REN INS IL6 EDN1 CRP
48	hyperuricemia	32.4	REN INS CRP APOB ALB
49	migraine with or without aura 1	32.3	NOS3 INS IL6 EDN1 CRP ALB
50	proteasome-associated autoinflammatory syndrome 1	32.3	INS IL6 CRP ALB ADIPOQ

Graphical network of the top 20 diseases related to Cardiovascular System Disease:

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Symptoms & Phenotypes for Cardiovascular System Disease

MGI Mouse Phenotypes related to Cardiovascular System Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.03	ACE ADIPOQ ALB APOA1 APOB CRP
2	liver/biliary system	MP:0005370	9.81	ACE ADIPOQ ALB APOA1 APOB IL6
3	muscle	MP:0005369	9.56	ADIPOQ ALB APOB EDN1 IL6 INS
4	renal/urinary system	MP:0005367	9.28	ACE ADIPOQ ALB EDN1 IL6 INS

Sources

Drugs & Therapeutics for Cardiovascular System Disease

Drugs for Cardiovascular System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1168)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dimethyl fumarate

Approved, Investigational

Phase 4

624-49-7

637568 5271565

Tranexamic Acid

Approved

Phase 4

1197-18-8

5526

Norethindrone

Approved

Phase 4

68-22-4

6230

Toremifene

Approved, Investigational

Phase 4

89778-26-7

3005573

Pantoprazole

Approved

Phase 4

102625-70-7

4679

Methimazole

Approved

Phase 4

60-56-0

1349907

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Ranolazine

Approved, Investigational

Phase 4

95635-55-5, 142387-99-3

56959

Tomato

Approved

Phase 4

Heparin

Approved, Investigational

Phase 4

9005-49-6

772 46507594

Epoprostenol

Approved

Phase 4

61849-14-7, 35121-78-9

5280427 5282411

Paroxetine

Approved, Investigational

Phase 4

61869-08-7

43815

Ritonavir

Approved, Investigational

Phase 4

155213-67-5

392622

Nicotine

Approved

Phase 4

54-11-5

942 89594

Cilostazol

Approved, Investigational

Phase 4

73963-72-1

2754

Saquinavir

Approved, Investigational

Phase 4

127779-20-8

60787

Enfuvirtide

Approved, Investigational

Phase 4

159519-65-0

16130199

Tipranavir

Approved, Investigational

Phase 4

174484-41-4

65027

Nevirapine

Approved

Phase 4

129618-40-2

4463

Didanosine

Approved

Phase 4

69655-05-6

50599

Amprenavir

Approved, Investigational

Phase 4

161814-49-9

65016

Indinavir

Approved

Phase 4

150378-17-9

5362440

Dipyridamole

Approved

Phase 4

58-32-2

3108

Ustekinumab

Approved, Investigational

Phase 4

815610-63-0

Ziprasidone

Approved

Phase 4

146939-27-7

60854

Altretamine

Approved

Phase 4

645-05-6

2123

Maraviroc

Approved, Investigational

Phase 4

376348-65-1

3002977

Sirolimus

Approved, Investigational

Phase 4

53123-88-9

5284616 6436030 46835353

Cisplatin

Approved

Phase 4

15663-27-1

84093 441203 2767

Everolimus

Approved

Phase 4

159351-69-6

6442177 70789204

Parathyroid hormone

Approved, Investigational

Phase 4

9002-64-6

Doxazosin

Approved

Phase 4

74191-85-8

3157

Vancomycin

Approved

Phase 4

1404-90-6

441141 14969

Propranolol

Approved, Investigational

Phase 4

525-66-6

4946

Nateglinide

Approved, Investigational

Phase 4

105816-04-4

60026

Repaglinide

Approved, Investigational

Phase 4

135062-02-1

65981

Regadenoson

Approved, Investigational

Phase 4

313348-27-5

219024

Colchicine

Approved

Phase 4

64-86-8

6167 2833

Insulin glargine

Approved

Phase 4

160337-95-1

Insulin detemir

Approved

Phase 4

169148-63-4

5311023

Rilonacept

Approved, Investigational

Phase 4

501081-76-1

104924

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Latanoprost

Approved, Investigational

Phase 4

130209-82-4

5282380 5311221

Travoprost

Approved

Phase 4

157283-68-6

5282226

Sevelamer

Approved

Phase 4

52757-95-6

Drospirenone

Approved

Phase 4

67392-87-4

68873

Tolvaptan

Approved

Phase 4

150683-30-0

216237

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Nebivolol

Approved, Investigational

Phase 4

152520-56-4, 118457-14-0, 99200-09-6

71301

Rotigotine

Approved

Phase 4

99755-59-6, 92206-54-7

57537

Interventional clinical trials:

(show top 50) (show all 8307)

#	Name	Status	NCT ID	Phase	Drugs
1	Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Stable Angina, NSTEMI and STEMI Undergoing PCI	Unknown status	NCT02012140	Phase 4	ticagrelor
2	A Morbi-Mortality and Remodeling Study With Valsartan in Patients With Hypertension and Cardiovascular Disease	Unknown status	NCT00133328	Phase 4	valsartan
3	Homocysteine Lowering and Atherosclerosis Reduction Trial (HART)	Unknown status	NCT00217178	Phase 4	Vitamins: Folic acid, B6, B12
4	Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines	Unknown status	NCT02797028	Phase 4	Allopurinol
5	HOPE-2 Study (Heart Outcomes Prevention Evaluation-2 Study)	Unknown status	NCT00106886	Phase 4	Folic acid, vitamin B6 and B12 or placebo
6	The Influence of Adalimumab vs. Fumaric Acid Esters on Cardiovascular and Metabolic Risk Factors in the Therapy of Patients With Moderate to Severe Psoriasis Vulgaris	Unknown status	NCT01088165	Phase 4	Adalimumab treatment arm;Fumaric acid esters treatment group
7	Does Administration of Vitamin D in African Americans With Hypovitaminosis D and Type 2 DM Improve Inflammatory Markers of Cardiovascular Disease?	Unknown status	NCT01153243	Phase 4	Ergocalciferol;Placebo pill
8	Does Rosuvastatin Delay Progression of Atherosclerosis in People With HIV Infection at Moderate Cardiovascular Risk? A Multicentre Randomized, Double Blind Placebo-controlled Trial	Unknown status	NCT01813357	Phase 4	Rosuvastatin
9	Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients	Unknown status	NCT00247494	Phase 4	mycophenol mofetil (MMF, Cellcept®) 500 mg BID
10	Levosimendan Versus Dobutamine in Cardiopatic Patients Undergoing Major Non Cardiac Surgery	Unknown status	NCT02012946	Phase 4	Levosimendan;Dobutamine
11	The Effects of Pravastatin and Rosuvastatin on the Tissue Characteristics and Morphology of Coronary Plaques in Patients With Stable Angina Pectoris	Unknown status	NCT01325818	Phase 4	pravastatin, rosuvastatin
12	Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease: a Randomized Clinical Trial	Unknown status	NCT01155128	Phase 4
13	The Effects of Thiazolidinedione on the Diabetic Retinopathy and Nephropathy	Unknown status	NCT01175486	Phase 4	Actos (Pioglitazone);Acarbose
14	Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being	Unknown status	NCT02796378	Phase 4	Training+Simvastatin+Q10-placebo;Training+Simvastatin-placebo+Q10-placebo;Training+Simvastatin+Q10
15	Adalimumab to Mitigate Cardiovascular Risk in RA Patients With Well-Controlled Joint Disease	Unknown status	NCT01893996	Phase 4	Adalimumab;Placebo
16	Multicenter, Randomized Trial Designed to Evaluate the Applicability of the Guidelines of the Italian Society of Diabetology for the Prevention of Cardiovascular Diseases in Type 2 Diabetes	Unknown status	NCT01240070	Phase 4
17	Hemocontrol's Effectiveness in a RAndomized Controlled Trial on the Reduction of Cardiovascular Long-term EventS	Unknown status	NCT01515878	Phase 4
18	Early Detection of Atherosclerosis in the Primary Care Setting: a Randomized Trial to Assess the Efficacy of a Novel Strategy in the Primary Prevention of Cardiovascular Diseases.	Unknown status	NCT00734123	Phase 4	Simvastatin or Atorvastatin;Enalapril;Aspirin or clopidogrel;Rimonabant
19	Randomized Open-label Comparative Study of Britomar (Prolonged Release Torasemide) and Diuver (Torasemide) to Assess Effects on Natriuresis and Central Hemodynamics in Patients With Arterial Hypertension and Chronic Heart Failure	Unknown status	NCT02087332	Phase 4	Prolonged release Torasemide (Britomar);Torasemide (Diuver)
20	Multi-centre Clinical Trial on Hormone Replacement Treatment in China	Unknown status	NCT01698164	Phase 4	estradiol plus MPA;Ximingting Tablet;estradiol plus progesterone
21	PPARGC1β And CNTN4 Genotype as a Pharmacogenetic Assay of Thrombosis and Bleeding Risks - a Cross-Over Controlled Trial of Aspirin in Individuals at Increased Cardiovascular Risk.	Unknown status	NCT02970604	Phase 4	Aspirin
22	A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES"	Unknown status	NCT01168700	Phase 4	aged garlic extract;Placebo
23	Phase IV: A Comparison of Reduced-dose Prasugrel and Clopidogrel in Elderly Patients With Acute Coronary Syndrome Undergoing Early Percutaneous Coronary Intervention (PCI)	Unknown status	NCT01777503	Phase 4	prasugrel;Clopidogrel
24	Normal Oxygenation Maintenance in Intensive Care Unit: Randomized Controlled Trial	Unknown status	NCT01319643	Phase 4	Oxygen
25	The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients	Unknown status	NCT00247507	Phase 4	acetylcysteine
26	Effect of Allopurinol on Mono and Co-administration With Statins on Platelets Reactivity on Diabetic Patiets Treated With Aspirin and Insulin	Unknown status	NCT03195153	Phase 4	Atorvastatin 80mg;ALLOPURINOL 300 MG;Atorvastatin 80mg AND allopurinol 300 mg
27	Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients	Unknown status	NCT02933788	Phase 4	Cilostazol;Acetylsalicylic acid
28	The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus	Unknown status	NCT02418884	Phase 4	rosuvastatin
29	Effects of Intensive Antihypertensive Therapies on the Risk of Stroke in Hypertensive Adults: A Prospective Randomized Open-Label Blinded-Endpoint Trial, a Feasibility Study	Unknown status	NCT02817503	Phase 4	Standard BP control;Moderate BP control;Intensive BP control
30	Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease: An Interventional and Methodological Study	Unknown status	NCT00235287	Phase 4	Candesartan and enalapril;candesartan and enalapril;candesartan and enalapril;candesartan and enalapril
31	Multicenter Trial on Clinical Utility of Acarbose in Patients With Ischemic Heart Disease Accompanied by Abnormal Glucose Regulation	Unknown status	NCT00858676	Phase 4	acarbose
32	Effects of Antihypertensive Treatment on Cardiac Remodelling and Metabolic Profile in HIV Infected Patients: Randomized Longitudinal Study With Candesartan Versus Lercanidipine	Unknown status	NCT00564057	Phase 4	candesartan;lercanidipine
33	Efficacy and Safety of Ivabradine in Hemodialysed Patients With Increased Heart Rate	Unknown status	NCT01364077	Phase 4	Ivabradine;Placebo
34	Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome	Unknown status	NCT01237769	Phase 4	Vitamin D3
35	Effects on Incidence of Cardiovascular Events of the Addition of Pioglitazone as Compared With a Sulphonylurea in Type 2 Diabetic Patients Inadequately Controlled With Metformin.	Unknown status	NCT00700856	Phase 4	add-on pioglitazone;add-on sulphonylurea
36	Hemostasis Pad Using Chitosan After Invasive Percutaneous Procedures	Unknown status	NCT02954029	Phase 4
37	The Efficacy of Lescol XL(Fluvastatin Extended Release 80 mg) on Atherosclerosis Progression in Patients With Newly Diagnosed Coronary Heart Disease	Unknown status	NCT01681199	Phase 4	Fluvastatin extended release tablet
38	A Strategy of Home Telehealth for Management of Congestive Heart Failure: STARTEL	Unknown status	NCT00247000	Phase 4
39	Clinical and Therapeutic Implications of Fibrosis in Hypertrophic	Unknown status	NCT00879060	Phase 4	spironolactone
40	Randomized Clinical Study to Assess the Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias	Unknown status	NCT01717469	Phase 4
41	Effect of Enteral Genistein Supplementation on Inflammatory Cytokines, Morbidity and Mortality in Patients With Sepsis	Unknown status	NCT02796794	Phase 4
42	Additive Renoprotective Effects of Oral Calcitriol in Nondiabetic Chronic Kidney Disease Patients	Unknown status	NCT01512862	Phase 4	Calcitriol;Placebo
43	Treatment of HYpertension: Morning Versus Evening	Unknown status	NCT02214498	Phase 4	Enalapril/hydrochlorothiazide;Placebo
44	Randomized Trial of the Association Between Low-Dose Statins and Nutraceuticals in High-intEnsity Statin-intoleRant patiENts With Very High Risk Coronary Artery diseasE	Unknown status	NCT02001883	Phase 4	Association low-dose statin and nutraceuticals
45	Comparison of Ultra-low-dose Oral Versus Trans-dermal Hormone Therapy on Coagulation Activation and Metabolic Risk Factors for Cardiovascular Disease	Unknown status	NCT02264743	Phase 4	Femoston Conti;EVOREL® CONTI
46	Phase 4 Study of Effects of ARB Compared With Diuretics in Hypertension Patients With High Cardiovascular Risks	Unknown status	NCT01011660	Phase 4	Amlodipine, Telmisartan, Amiloride Compound , Simvastatin
47	Comparison of High-Dose Rosuvastatin Versus Low Statin Dose Plus Fenofibrate Versus Low Statin Dose Plus Niacin in the Treatment of Mixed Hyperlipidemia	Unknown status	NCT01010516	Phase 4	High-dose rosuvastatin;Statin plus fenofibrate;Statin plus niacin ER/laropiprant
48	Evaluate Efficacy and Safety of Extended Adjuvant Treatment With Letrozole in Postmenopausal Women With Hormone Receptor Positive Breast Cancer Who Have Completed 5 Years of Toremifene	Unknown status	NCT01072318	Phase 4	Letrozole
49	Antiatherogenic and Antimetabolic Effect of Curcumin in Type 2 Diabetic Patients	Unknown status	NCT01052597	Phase 4	curcumin
50	Antiatherogenic and Antimetabolic Effect of Curcumin Therapy in the Prevention and Delay of Type 2 Diabetic in Patients With Impaired Glucose Tolerance and Insulin Resistance	Unknown status	NCT01052025	Phase 4	Curcumin

Search NIH Clinical Center for Cardiovascular System Disease

Cochrane evidence based reviews: cardiovascular diseases

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Genetic Tests for Cardiovascular System Disease

Genetic tests related to Cardiovascular System Disease:

#	Genetic test	Affiliating Genes
1	Disorder of Cardiovascular System ²⁹	ACE
2	Abnormality of the Cardiovascular System ²⁹

Sources

Anatomical Context for Cardiovascular System Disease

MalaCards organs/tissues related to Cardiovascular System Disease:

⁴⁰

Heart, Endothelial, Kidney, Testes, Bone, Liver, Breast

Sources

Publications for Cardiovascular System Disease

Articles related to Cardiovascular System Disease:

(show top 50) (show all 2957)

#	Title	Authors	PMID	Year
1	Intracellular delivery strategies for microRNAs and potential therapies for human cardiovascular diseases. ⁴⁶	Shi MA...Shi GP	21045204	2010
2	MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. ⁴⁶	Fang Y...Davies PF	20624982	2010
3	MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. ⁴⁶	Menghini R...Federici M	19786632	2009
4	miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. ⁴⁶	Cordes KR...Srivastava D	19578358	2009
5	MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. ⁴⁶	Fasanaro P...Martelli F	18417479	2008
6	Citric acid-enhanced dissolution of polyphenols during soaking of different teas. ⁶¹	Li W...Lu Y	31506961	2019
7	A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation through restoration of autophagy flux. ⁶¹	Ma Y...Fang N	30321700	2018
8	Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset. ⁶¹	Wan L...Yu G	29439675	2018
9	Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124. ⁶¹	Chen J...Sang H	29042195	2017
10	[Nursing care in elderly patients with cardiovascular disease]. ⁶¹	Enc N...Oz Alkan H	28976398	2017
11	Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. ⁶¹	Zhang Y...Trayanova NA	27138523	2016
12	Farnesoid-X-receptor expression in monocrotaline-induced pulmonary arterial hypertension and right heart failure. ⁶¹	Ye L...Zuo X	26392308	2015
13	[Hyperprolactinaemia and bone mineral density]. ⁶¹	Kostrzak A...Meczekalski B	26319389	2015
14	Elderly deaths in Ankara, Turkey. ⁶¹	Akar T...Ozkok A	24962235	2014
15	Association of adrenergic receptor gene polymorphisms in gallbladder cancer susceptibility in a North Indian population. ⁶¹	Rai R...Mittal B	24556804	2014
16	Denervation of nerve terminals in renal arteries: one-year follow-up of interventional treatment of arterial hypertension. ⁶¹	Bartus K...Sobotka PA	24408071	2014
17	[Retrospective analysis of 190 cases of hospitalized patients with psoriasis]. ⁶¹	Shi J...Zhang G	24384952	2013
18	[Biomarkers and risk factors of cardiovascular system disease in diabetes mellitus type 2]. ⁶¹	Prystupiuk OM	23951913	2013
19	Atrial natriuretic peptide and oxidative stress. ⁵⁴	De Vito P...Luly P	20385186	2010
20	No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis. ⁵⁴	Caliebe A...Nebel A	20362697	2010
21	Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure. ⁵⁴	Van der Zwan LP...Teerlink T	20385972	2010
22	Dalcetrapib: a review of Phase II data. ⁵⁴	Robinson JG	20465364	2010
23	Adenoviral-mediated overexpression of DDAH improves vascular tone regulation. ⁵⁴	Torondel B...Leiper J	20219849	2010
24	Neuropeptide Y and sleep. ⁵⁴	Dyzma M...Kerkhofs M	20122859	2010
25	Soluble form of a receptor for advanced glycation end products (sRAGE) as a biomarker. ⁵⁴	Yamagishi S...Matsui T	20515790	2010
26	Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. ⁵⁴	Oishi Y...Nagai R	20086047	2010
27	Residential traffic exposure, pulse pressure, and C-reactive protein: consistency and contrast among exposure characterization methods. ⁵⁴	Rioux CL...Brugge D	20123638	2010
28	Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase. ⁵⁴	Dobrzyn P...Dobrzyn A	20205608	2010
29	Association of serum adiponectin with risk for cardiovascular events in patients with peripheral arterial disease. ⁵⁴	Urbonaviciene G...Lindholt JS	20096841	2010
30	ADMA, C-reactive protein, and albuminuria in untreated essential hypertension: a cross-sectional study. ⁵⁴	Tsioufis C...Stefanadis C	20189274	2010
31	Changes in the immune system during menopause and aging. ⁵⁴	Gameiro C...Romao F	20515802	2010
32	Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. ⁵⁴	Blum S...Levy AP	20415560	2010
33	Hormonal modulation of endothelial NO production. ⁵⁴	Duckles SP...Miller VM	20213497	2010
34	Gene therapy to improve high-density lipoprotein metabolism and function. ⁵⁴	Van Craeyveld E...De Geest B	20196736	2010
35	N-terminal ProBNP distribution and correlations with biological characteristics in apparently healthy Greek population: ATTICA study. ⁵⁴	Fragopoulou E...Stefanadis C	19815605	2010
36	High mobility group box-1 and cardiovascular diseases. ⁵⁴	Ding HS...Yang J	20464035	2010
37	Therapeutic interventions to enhance apolipoprotein A-I-mediated cardioprotection. ⁵⁴	Haas MJ...Mooradian AD	20297868	2010
38	Pro-atherothrombotic effects of leptin in human coronary endothelial cells. ⁵⁴	Cirillo P...Chiariello M	20174754	2010
39	Albuminuria, impaired kidney function and cardiovascular outcomes or mortality in the elderly. ⁵⁴	Rifkin DE...Sarnak MJ	20008829	2010
40	The role of FGF-23 in CKD-MBD and cardiovascular disease: friend or foe? ⁵⁴	Larsson TE	20124546	2010
41	A significant decline in IGF-I may predispose young Africans to subsequent cardiometabolic vulnerability. ⁵⁴	Schutte AE...Schutte R	20215395	2010
42	ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production. ⁵⁴	Mattaliano MD...Paulsen JE	20181930	2010
43	Association of serum lipoprotein ratios with insulin resistance in type 2 diabetes mellitus. ⁵⁴	Tangvarasittichai S...Tangvarasittichai O	20516535	2010
44	Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-kappaB. ⁵⁴	Huang F...Zeng H	20458445	2010
45	Higher leptin levels in Asian Indians than Creoles and Europids: a potential explanation for increased metabolic risk. ⁵⁴	Lilja M...Soderberg S	20125099	2010
46	The axis of thrombospondin-1, transforming growth factor beta and connective tissue growth factor: an emerging therapeutic target in rheumatoid arthritis. ⁵⁴	Rico MC...DeLa Cadena RA	19485899	2010
47	[Anti-diabetic drugs for secondary prevention of cardiovascular disease in mild diabetic and IGT patients: ABC study and PPAR study]. ⁵⁴	Asakura M...Kitakaze M	20446588	2010
48	Association between apoliprotein E gene polymorphism and hypercholesterolemic phenotype in Maracaibo, Zulia state, Venezuela. ⁵⁴	Arraiz N...Velasco M	20019593	2010
49	Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin. ⁵⁴	Cerda A...Hirata RD	20064494	2010
50	The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans. ⁵⁴	Shah A...Millar JS	20005515	2010

Sources

Genes for Cardiovascular System Disease

Genes related to Cardiovascular System Disease (2 elite genes):

(show top 50) (show all 159)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MIR210	MicroRNA 210	RNA Gene	361.23	Causal ⁴⁶ DISEASES inferred ¹⁵ ¹⁵	18417479
2	CDKN2B-AS1	CDKN2B Antisense RNA 1	RNA Gene	157.22	Experimental evidence: Mutation ³⁸ DISEASES inferred ¹⁵	20716961 22382030 23104877 (more) 24113581 24531795
3	NPPA-AS1	NPPA Antisense RNA 1	RNA Gene	154.51	Experimental evidence ³⁸ DISEASES inferred ¹⁵	22817756
4	HIF1A-AS1	HIF1A Antisense RNA 1	RNA Gene	154.5	Experimental evidence ³⁸ DISEASES inferred ¹⁵	25761653
5	ACE	Angiotensin I Converting Enzyme	Protein Coding	120.71	Genetic Tests ²⁹ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	16476718 17875946 14704227 (more) 11256587 8743524 11344778 17504232 16924268 10874503 16222900 17898539 8591889 1414888 19290794 17103020 11986905 19491618 15161784 12643119 9747149 15567997 15332219 12818733 12676161 11401108 11071385 10483967 9786099 8768273 15868120 7713109 19221299 9143778 15215792 14608518 11288962 19770395 1562174 8886509 9327710 9677696 9736776 9808697 10354208 11059628 14707162 12873287 12669427 12661913 12519409 11498459 11401071 11345362 11228171 7602784 7739115 7856275 7965262 1381783 2344816 20019467 7955173 20066135 12710862 12220962 11882622 11835905 10876800 10695707 10639547 9868993 9752816 19888787 17199216 19878370 18084312 18449379 18383770 17885543 17243909 16769256 11142763 10999650 10821349 10520809 10351920 10794598 9717054 9120994 8877073 8872813 8773433 8903616 8065033 7512465 1290308 16444043 16921734 16462911
6	MIR145	MicroRNA 145	RNA Gene	60.93	Unspecified ⁴⁶ DISEASES inferred ¹⁵ ¹⁵	19578358
7	MIR10A	MicroRNA 10a	RNA Gene	60.43	Unspecified ⁴⁶ DISEASES inferred ¹⁵ ¹⁵	20624982
8	MIR143	MicroRNA 143	RNA Gene	60.36	Unspecified ⁴⁶ DISEASES inferred ¹⁵ ¹⁵	19578358
9	MIR217	MicroRNA 217	RNA Gene	55.53	Unspecified ⁴⁶ DISEASES inferred ¹⁵	19786632
10	INS	Insulin	Protein Coding	21.26	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15717879 15660727 17420421 (more) 7652727 15208835 16980199 16334591 18974244 14764276 17023708 15159251 9590566 20001427 19114407 14976002 9861517 8462390 1736105 18309108 17954428 16506274 14968294 12627878 18779682 16581078 9240771 19138313 16259222 12957327 16054467 9100707 17368007 1457758 7981184 10707556 9270410 8856394 12150695 12692007 19015938 18775353 18640389 17873318 17320517 17183416 17218834 15998260 15579783 16820727 16392771 16319655 14647894 14553866 11997182 14739074 12647277 12408408 12365467 10821297 10440591 10374288 8299479 19149565 7828781 2065046 19572942 19421860 19564534 18927552 18296327 17826042 17760500 17259501 16522281 15075712 12877091 12702035 12675638 8949974 19731182 19164269 17952838 16839860 15590982 14626524 12610050 12540621 12148078 10024191 8964200 7782801 20513276 19369429 19214921 18772854 16697386 17181562 15258201 15047659
11	CRP	C-Reactive Protein	Protein Coding	21.05	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15529024 12823355 18855714 (more) 10393687 16905938 11849404 12943870 18060926 19667982 10569656 19240794 17584093 17220790 14742804 14566035 16431250 15148294 17266610 11238289 10192648 17276184 17203810 15585211 15955978 20206126 19690638 17973918 18677173 17044846 12620166 10764673 16939632 16534007 15811980 14709450 18952164 19329405 17893410 17511977 17174735 16901413 16265340 15205370 15147103 16238678 18702945 18300125 19228486 17055707 17283264 17077623 15505005 11926788 10229731 9727541 9351386 18691271 19365169 19075099 17551260 12186793 16125489 19423845 15078802 10590187 11950696 12006917 12850240 14625121 15184288 15323255 15900306 15975559 15857269 15791030 15722558 15668660 15284086 15467191 15451155 17949793 18294231 18262272 17342166 17878255 18163969 17637303 17310862 16958597 10807156 20123638 20234030 19808911 19243779 18501446 19398609 19426506 18289549 17716549
12	APOB	Apolipoprotein B	Protein Coding	19.45	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18560450 18220807 19168552 (more) 19200547 17953518 10961094 11883334 19456221 12547700 15955978 17890784 18333887 18498273 19068318 19497316 10588084 12297895 12492446 12649091 15277429 15843229 16798966 11995245 11006895 9651904 9636203 8546746 2123624 19952033 16432543 16629852 17672218 14770189 12624282 9846102 7652481 2163516 19355857 18720348 17234819 17170368 17277465 16257193 17002798 15716585 14746139 12447639 15805152 15047470 18633759 17701049 18277343 17969379 17631073 17030687 19051333 16281487 16034221 19829109 18958843 18607182 17544386
13	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	19.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18027814 17253436 16581078 (more) 19389061 19261992 15780820 19906806 17101706 17873318 18336252 17161223 19227810 18241619 17145218 16324920 15827100 15589686 19821969 18387655 19245516 19159917 18029194 19675525 17646605 17572841 17140553 17142348 16219717 19857072 12660876 15132729 15502925 18191060 18344634 16210704 15761179 15070917 20154470 19640365 19371199 19106327 18632660 18762168 15569472 15168385 11344187 19874712 18591880 18989258 18798447 18594137 19773737 15670203 15114523 20096841 19845523 20066136 19172446 19359049 19157250 18472407 14633805 14627760 14592564 12914718 18362426 18084018 17457380 17633232 16756736 16320084 17970534 18593221 17645557 17224001 17391153 16427606 16939660 16464169 19223612 19136982 18434424 18069030 18370712 17893263 17950098 17322479 17495599 17003095 17215175 16231029 16202556 16973279 16551729 15616802 17303804 17505621 17030960 17046559
14	NOS3	Nitric Oxide Synthase 3	Protein Coding	19.11	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17108813 19407804 18331440 (more) 15494775 18349107 20082095 18617528 10393506 16845178 16418168 11692081 12716763 18086002 9806747 15790928 18079690 18713021 17496167 17382196 17082313 16873694 16492203 15890550 15565175 11129410 10600037 18200826 17018701 16060860 14576373 12142730 11849440 11431031 9461225 9314409 15712782 15255799 12503100 11595733 11693755 10484073 20350698 19605523 17584103 19505886 18252813 17399719 16113535 15091109 11720085 11707686 10781649 10442857 19376104 19077211 17264164 16170835 16093452 16231020 16502366 16585403 15636445 15211444 12364322 20422736 18551994 19486510 18692595 15123766 14675775 12837457 12586536 12381413 20213497 18640391 18230825 17243909 10543322 9564764 19463074 16531750
15	ALB	Albumin	Protein Coding	19.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1553966 7606307 9229197 (more) 1353802 8862223 19150611 15956113 16377395 8273237 9612878 16178477 10800280 16980573 9662051 8427856 10419073 11422658 11849464 8504630 16429841 11849404 11845230 10922975 10898045 10446083 9767548 9416983 7485062 10809241 10335721 10333909 9686391 8086657 8243884 8478855 19609391 19460474 12356649 11982822 11941273 11574957 10886588 10580435 9179466 7922240 8105164 11157375 10872702 9389420 9226225 8785388 8546125 7629407 2168768 16238681 11294805 9573549 9349601 8140398 8345490 1993322 20189274 20016051 20098471 19145004 19028824 17159023 15962607 15177126 12969166 11431186 18790809 18337481 18558299 16280473 15125372 12690921 12606536 12460872 8481551 1625684 2142055 19915481 19450204 18834870 12389063 10817400 19093915 18617580 18394058 18596379 18487797 17875308 16580621 16413943 12163426 2137750 12703884 15198838
16	SERPINE1	Serpin Family E Member 1	Protein Coding	18.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18050673 9187410 10695479 (more) 16039281 10648020 16126968 15311550 18600083 20205861 11567663 14995993 11567664 14678868 8060375 11278457 12728597 16477805 15919609 15380459 14963283 14553864 10208482 10064006 9843166 19918669 17850750 12871373 15080492 11733024 11179976 11129405 10520809 10364094 10980830 9498632 14605330 12911596 12719278 12734779 12195702 11816701 11522017 11373350 10798278 9041098 9005966 16789641 15988701 11092431 11057874 10831181 9734732 9423801 9198234 18501910 15820196 14746139 12891381 11372681 10452346 9622268 18624608 17161063 16128865 12911589 11588944 11525072 10417403 9805421 9161416 9258409 19889809 18559377 17970534 18593221 16427606 15630497 14993864 9048903 9031456 8831916 18191049 17014002 15901895 15379715 12921488 7698502 7813812 8241103 8462390 19888787 19132219 16939632 16522281 16091487 15575342 12723974 12540956 11197396
17	APOA1	Apolipoprotein A1	Protein Coding	18.83	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15314690 16901406 15498770 (more) 17234819 16798073 16452169 18388068 19456221 20178050 12471038 19237735 18277343 17969379 17631073 17699012 16368749 16030277 1451121 19800416 18565099 17699011 14746139 12573361 11313781 11006895 9987089 8943493 8546746 2123624 19068270 19055467 16187691 12417283 11827556 9915567 7615839 19355857 19952033 18702334 17240315 15574409 11943562 10646643 7767918 18519851 16798966 17298957 18333887 19179308 20196736 8400337 12957326
18	IL6	Interleukin 6	Protein Coding	18.83	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	20064818 15784406 20059469 (more) 20203323 12943870 16467451 15854959 16377395 17596140 15090695 18034847 16087797 11230284 19936194 8607801 11887976 15882283 15876998 17665966 9583349 16472051 15955978 15663921 15179102 15136493 15070917 14962637 12788842 10695556 19669729 18347604 18928156 18781928 18296371 18195475 18091699 17194638 16313298 15590982 15205588 15161792 12846758 9125293 20164544 19509100 17970534 17852073 11677362 20129796 19439300 19223201 19608012 17879575 17684929 17335789 17242212 15078584 14978155 14671050 12637697 11766356 19913852 16797387 16216472 15756217 15364891 12544661 11230338 11114578 19702114 18449539 18274928 17196470 16839861 16960028 16458279 15705924 15753186 17911176 17878722 17687823 17404162 17132648 16900203 16464786 16360159 12163427 19836021 19319930 18195193 18257336 18179502 17698692 17322479 20515802 19903755 19744034 17059420 15604420
19	REN	Renin	Protein Coding	18.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	19410337 19278599 1759997 (more) 7516858 2110974 12692747 20010781 15983245 9226225 8293766 18237679 9120665 20041594 18611061 18221088 12676161 12431022 11953098 18764720 15526242 10903938 8615291 2232318 19715410 8573547 18340340 7983230 14728059 8877073 7965262 8788503 12927775
20	EDN1	Endothelin 1	Protein Coding	18.18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17617392 20217138 19057845 (more) 11078363 8981573 9546947 10077237 10877200 11078425 17164035 18288492 19111553 19150882 19506099 20083432 20491339 7916401 9176309 10434349 11005584 11425780 8971583 8752200 17827914 16809937 12143942 11811378 10976779 9591497 8904934 18555838 16248779 12686474 11869173 11566914 9110115 19967386 19779116 18062774 17019099 16101562 12688403 12236017 10651255 9595409 8160238 18047620 17580594 19564455 16787211 11811372 11411770 10949163 9494073 9409267 9354313 9093521 16505174 15018244 11953098 11725953 11385185 10065339 9859740 9381781 19907721 18954524 18675382 17965745 15257257 14655103 14597580 12616854 11419917 10494802 9449382 20339975 12839265 14748289 16740999
21	APOE	Apolipoprotein E	Protein Coding	18.18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	16161810 8867586 12015945 (more) 15653176 11807900 20074603 11257253 9801016 8557181 8198763 9693262 10428303 10632725 12850485 17662693 18378224 15374172 9564764 11120871 11814460 12182119 12190886 15505371 16955690 17676504 17426996 18562290 18156097 17911980 16644874 15276651 12196500 11177205 10655544 8399082 10406818 9706883 9611077 9238027 19891383 19252179 17462871 16817024 16786033 11369364 10620569 20429872 20019593 17763167 17332893 17240315 16282567 16815851 11882522 11106322 9472879 9012642 1947727 19636906 18298348 17715945 17684217 17308333 16815257 16106048 15830139 14746139 12573381 12473848 12086087 15780204 15585780 12796755 12739024 12544661 11470126 10754375 10587578 16013355 15935014 15226466 12473860 11891412 10851367 19943806 19641010 7497860 18320120 16671834 17702862 17044846 16266401 18376080 1911720 8782820 10553197 10094101 10818513 11803456
22	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	18.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9449684 9702074 9740630 (more) 16519598 7713122 12518185 18182232 10738546 11134677 18360014 16274774 8613189 19330904 16504375 7713099 19475773 16732715 17146658 18422392 16121033 14654250 11707686 11106322 10937949 9717050 8773261 17305412 10351920 19888787 10876800 8993854
23	LEP	Leptin	Protein Coding	18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18926322 10583712 10757633 (more) 17161223 18431365 10334326 17007277 19001191 15702617 16261186 15292320 15202616 18387655 9933268 11997182 20174754 16335797 12370213 14699970 14514596 12880566 19571581 18574061 17322479 17175979 17210981 16116494 15937081 20066136 19172446 19148833 19112726 17970534 16940932 15886225 15331885 15117839 20458445 19132788 18959828 18832901 18160070 17872473 16648622 16720637 12903905 11935372 18820649 18651469 17207790 17240315 15827100 12647279 19944469 15234549 14871050 14749504 12190889 18474180 16362081 16404479 15927298 18726825 16320084 15670203 15375794 15072562 12872039 12423321 11472752 14615386 14629465 12674182 11795261 19846168 18723235 18195475 16712853 20125099 19584182 18775082 17878255 16735961 15919793 15968576
24	COG2	Component Of Oligomeric Golgi Complex 2	Protein Coding	17.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	16185099 15177127 17636341 (more) 17996658 18332269 18173956 19574922 19891279 20516535 15780204 18834233
25	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	17.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15561486 15837084 17899317 (more) 12499324 11058711 15494775 10428303 11481907 12927690 16531750 16958597 9051203 10926884 11433922 11916749 14728017 11532106 9510851 8873653 8554066 15226189 15073633 11692165 15889539 14577615 12544661 11287760 10512925 9774778 9583842 9130949 15583437 19609317 17976958 12370778 11749660 10781649 8940272 19952781 19376104 11683544 11406421 9974399 17240315 16605249 16634455 16046727 11419077 10408794 9868588 18840629 19882941 17917766 15735068 12196500 11274026 10329022 9327760 11168432 12146133 12356947 16602021
26	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	17.32	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15962651 10912119 11228171 (more) 15922259 16185099 17242008 17493470 19848438 19791839 20190699 10090116 11684078 11772284 15598024 17209661 17392488 17520093 18158500 17927279 18700910 19224538 19940267 11057120 12921488 16921390 17174224 18506803 19318042 20005478 10860000 12002257 12745170 16034478 16581326 19376844 16185181 14727946 14742804 12815379 19804261 18622257 18366980 17293685 16803418 16849890 17608248 18332269 18473714 18540668 19254829 15320474 15449961 15472596 16503718 15836008 17563259 18200826 18457539 9694549 10091528 11164838 12390056 16113468 16871575 18261733 11030795 11477342 12752842
27	VWF	Von Willebrand Factor	Protein Coding	17.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	19439298 10648020 11887976 (more) 15755826 16322530 16449948 20008188 12370220 12792699 15380459 16236894 17507174 9498659 10580169 12563218 12921488 19029465 2142055 17555832 8118478 16158039 16095049 15662616 17598011 16807651 15562207 12911589 12399074 11426020 7491837 12945874 17132648 19506354 7972262 11427638 16458279
28	LPA	Lipoprotein(A)	Protein Coding	17.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	7857388 9693262 10751199 (more) 1345006 9051192 19307470 20196736 8400337 15003733 8329699 7819711 17541022 11122750 11882522 19636317
29	PON1	Paraoxonase 1	Protein Coding	17.11	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18355454 15990587 19474728 (more) 19201174 17977159 12525679 9746266 10411705 12618279 15166781 15243212 15375178 15458977 16438805 17712585 17915616 17301599 15251338 15016430 14505812 11803456 16681435 19550323 18796237 19779116 19082953 17971175 17359486 16926679 14998248 14579013 12909569 10462749 16112460 15576850 12489064 9240427 20002083 19318033 18704198 17598371 16517986 20112598 19319852 18608549 17032345 15613429 15670573 7564664 19151417 18164014 15454270 15023811 12204423 10373401 9011577 20348046 20332543 19540141 18830558 19371607 16120573 12196500 20362697 18281420 17512573 17692153 18349088 10898114 11151764 15336559 15642273 16540037 17651311
30	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	16.97	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18034623 18288280 15503647 (more) 16316298 19318113 17360982 18799592 18401448 11698662 10934348 17145061 16106185 16511589 18586686 18628776 17169249 17237841 16484544 18436144 18173954 17496434 17194889 11864924 20446588 20005515 19515415 18509489 18241614 17413033 17307056 14501584 19386311 18311660 16672917 10408502 18420459 18221086 17363837 11374025 19822141 17593234 12570700 16116345 15142970 19500491 18336366 12163127 15528894 17935055
31	NPPB	Natriuretic Peptide B	Protein Coding	16.96	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	19702933 9093047 9286500 (more) 17210472 12239593 17257357 16958597 16011727 18356635 15325948 16330398 17426794 9366809 17266610 18307738 16105071 18552579 12633801 8877790 16599827 16221702 15983245 10562924 8613267 19796740 18362428 16784419 16344502 15385748 11558683 8952587 8282365 19815605 18039187 16623357 16538971 16234898 19387249 18058731 16585413 12681464 12422152 12225726 8083346 20040348 19396053 18632852 18588432 16092582 16352258 16601459 15887397 15643118 9095445 16893713 14987578 12381941 19760573 19917883 17536606 19274732 19631175 16633992 18394002 18420944 17375888 17244121 18505615 17340039 18620103
32	TNF	Tumor Necrosis Factor	Protein Coding	16.95	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17705580 15854959 12943870 (more) 11453575 10433867 12191598 11887976 15692810 18487876 9530222 10695556 15179102 16472051 11997182 20443835 20016776 19736814 19012050 19118493 18673161 18370712 18257336 18273720 17883332 17663929 17377521 16150792 16243340 12873047 11566619 18928156 16797387 16260427 15893134 15257473 15122056 12914718 12006640 11114578 17328057 19729864 19641672 16456090 16224057 15246652 12517724 11007832 10707566 20009917 16174491 11693755 19913852 17849692 16840748 16320084 15753186 15159291 12843690 11744409 19509100 18418430 18781928 18195475 17356550 16636217 16857167 15808915 15084512 14514596 15996054 15663921 11846495 9990527 18814905 15784406 16218487
33	CETP	Cholesteryl Ester Transfer Protein	Protein Coding	16.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15939053 18243217 18620517 (more) 17257272 17257461 15856070 7583564 12691171 16439711 18646836 19436720 19948970 18957472 17784782 17440012 17531380 20465364 20297868 17409111 16226917 15324321 12639975 11888533 18468607 18503096 18509195 18607187 18518852 17196207 15450208 19085339 17852818 17277799 16503868 15681846 15738977 18287799 17949364 16861609 12889988 17237796 19948972 12376088 14559957 15857309
34	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	16.9	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	19566488 15030267 15627719 (more) 11919402 12818967 18257336 12640339 18328350 15122056 19781803 19014891 18579536 16814297 20009917 15520826 19068240 18339698 20140679 16099464 17665966
35	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	16.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	19129679 15320743 20158101 (more) 18417957 11872377 14732733 16335797 16556873 12663371 16360030 19646657 11374025 19228871 18580862 18370623 18288288 16831022 14566384 19796634 18552452 19808901 19515415 19490202 18308193 18241614 18071073 18001313 16563944 15117825 19117570 18220629 18288291 17076999 11861659 12957321 10408502 19569080 17240171 15830032 15234647 14521714 12861348 18173954 15142970 19620300 17164134 16696956 18922179 19118492
36	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	16.81	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	10648020 15692257 12891381 (more) 8528854 16126968 14983217 16796017 17404162 16807651 18953568 12463111 11372681 7996060 19889809 15901895 15379715 12921488 10207029
37	SELP	Selectin P	Protein Coding	16.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11726042 16449250 12370220 (more) 15136493 17598012 20193033 19300046 19590054 17687823 14659768 19232335 10775025 12399074 15683111 19691482 11597943 9529262 12911583
38	RETN	Resistin	Protein Coding	16.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18220599 17175295 18446183 (more) 19223612 11994397 17003095 18195475 19740705 18723235 15710760 17970534 19639497 15670203 16104844 16515776 17498119 19454585 19828833 19940327 12874180 12914718 16159596 17302872
39	SELE	Selectin E	Protein Coding	16.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11726042 16322530 19171188 (more) 19903755 11051283 12640339 14652631 18591880 9242960 12945874 14675775 19509100 14988255 17397316 10449693 20009917 20191078 11172623 15833936 17555832
40	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	16.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11726042 17148932 18225982 (more) 18504269 20193033 16332659 20009917 16564549 20368209 11172623 17397316 15257473 12640339 18296371 10409552
41	AGT	Angiotensinogen	Protein Coding	15.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11345362 16033904 16531750 (more) 16513650 16908765 11751722 8695029 18675382 19348233 16969748 7713099 7713117 11228750 17489676 9793075 10703882 17975262 12806586 19669395
42	KNG1	Kininogen 1	Protein Coding	15.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11975815 17212359 16023651 (more) 10952948 17716647 16387685 19628666 11233272 11694220 7713109 11281230 11288962 11355044 9680670 11881101
43	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	15.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15262183 16183915 17093293 (more) 16446539 12615648 18541924 16806540 12236582 16879828 16235041 12407001 19783654 11927274 17383594
44	MIR199A1	MicroRNA 199a-1	RNA Gene	15.79	DISEASES inferred ¹⁵ ¹⁵ ¹⁵
45	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	15.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17610342 11353578 17409575 (more) 19114086 15018246 15171358 14608520 18174920 19541744 19337952 15945295 15808807 15824460 20226957 15860254 15554912 15218387 18729003 19307693 19168055 15947887 17234708 19590161 18277151 19804189 15257862 16286565 16879778
46	CST3	Cystatin C	Protein Coding	15.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17996317 16838182 16609294 (more) 20207770 20008829 16908914 18508621 19374014 20082582 14628480 14726415 18704820 19357259 17998494 17394021 17234172 17289743 17234819 15809461 18378946 18787643 20233980 18187137 18480203 19765773 16712749 17429295 18940290 19622349 17205961
47	LDLR	Low Density Lipoprotein Receptor	Protein Coding	15.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	12691171 12589187 16078748 (more) 18243212 18700895 11082209 12436241 12492446 20080547 7857390 9275065 9734729 15047497 7635461 18261733 9636203 14746139 15384479 15823280
48	LPL	Lipoprotein Lipase	Protein Coding	15.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17803213 9498535 9662394 (more) 12652096 12691171 9081692 20350420 16574898 9846102 17484619 11073182 19052449 10406818 20429872 10636447 16106048
49	PDE5A	Phosphodiesterase 5A	Protein Coding	15.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15083994 16409215 18040025 (more) 16387566 20101899 16156423 16387565 18953278 16018863 16387575 17017939 16387567 16036043 15574127 11351772 16185664 15115192 18674473 14609621
50	THBD	Thrombomodulin	Protein Coding	14.99	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1725416 11919402 14624417 (more) 15755826 12921488 12945874 16456088 10231031 15869594 16095049 19609862 17677000

Sources

Variations for Cardiovascular System Disease

Sources

Expression for Cardiovascular System Disease

Search GEO for disease gene expression data for Cardiovascular System Disease.

Sources

Pathways for Cardiovascular System Disease

Pathways related to Cardiovascular System Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Adipogenesis ¹	11.68	SERPINE1 INS IL6 ADIPOQ
2	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.5	SERPINE1 INS IL6 CRP APOB APOA1
3	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶⁰ Show member pathways ACE Inhibitor Pathway ¹ ACE Inhibitor Pathway, Pharmacodynamics ⁶⁰ Renin-angiotensin system ³⁶	11.48	REN NOS3 ACE
4	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.46	SERPINE1 NOS3 IL6 EDN1
5	HIF-1 signaling pathway ³⁶	11.39	SERPINE1 NOS3 INS IL6 EDN1
6	Renin secretion ³⁶	11.38	REN EDN1 ACE
7	FOXA2 and FOXA3 transcription factor networks ¹	11.14	INS APOA1 ALB

Sources

GO Terms for Cardiovascular System Disease

Cellular components related to Cardiovascular System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	SERPINE1 REN INS IL6 EDN1 CRP
2	endoplasmic reticulum lumen	GO:0005788	9.55	INS IL6 APOB APOA1 ALB
3	extracellular space	GO:0005615	9.47	SERPINE1 REN MIR210 MIR143 MIR10A INS
4	intermediate-density lipoprotein particle	GO:0034363	9.26	APOB APOA1

Biological processes related to Cardiovascular System Disease according to GeneCards Suite gene sharing:

(