Cardiovascular System Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRD246 MIFTS: 59	Cardiovascular System Disease Categories: Blood diseases, Cardiovascular diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Cardiovascular System Disease

MalaCards integrated aliases for Cardiovascular System Disease:

Name: Cardiovascular System Disease ¹¹ ¹⁴

Abnormality of the Cardiovascular System ²⁸ ⁵

Cardiovascular Disease ¹⁶ ⁷⁵

Disease of Subdivision of Hemolymphoid System ¹¹

Disorder of Cardiovascular System ²⁸

Cardiovascular Diseases ⁴³

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the circulatory system

Other forms of heart disease

Complications and ill-defined descriptions of heart disease

Cardiovascular disease, unspecified

External Ids:

Disease Ontology ¹¹ DOID:1287

ICD9CM ³⁴ 429.2

MeSH ⁴³ D002318

NCIt ⁴⁹ C2931

SNOMED-CT ⁶⁸ 266275004

ICD10 ³¹ I51.6

EFO ¹⁶ EFO_0000319

UMLS ⁷¹ C0007222

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Summaries for Cardiovascular System Disease

Disease Ontology: ¹¹ A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.

MalaCards based summary: Cardiovascular System Disease, also known as abnormality of the cardiovascular system, is related to coronary heart disease 1 and heart disease. An important gene associated with Cardiovascular System Disease is KCNQ1 (Potassium Voltage-Gated Channel Subfamily Q Member 1), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Dydrogesterone and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related phenotypes are muscle and homeostasis/metabolism

Wikipedia: ⁷⁵ Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD... more...

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Related Diseases for Cardiovascular System Disease

Diseases in the Cardiovascular System Disease family:

Autoimmune Disease of Cardiovascular System

Diseases related to Cardiovascular System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1751)

#	Related Disease	Score	Top Affiliating Genes
1	coronary heart disease 1	33.2	SERPINE1 INS CRP APOE APOB APOA1
2	heart disease	33.2	SERPINE1 NOS3 MIR210 KCNQ1 INS IL6
3	vascular disease	33.1	SERPINE1 NOS3 MIR145 MIR143 INS IL6
4	diabetes mellitus	32.9	SERPINE1 NOS3 MIR210 MIR145 MIR143 KCNQ1
5	type 2 diabetes mellitus	32.9	SERPINE1 NOS3 MIR210 MIR145 MIR143 MIR10A
6	heart conduction disease	32.8	MIR145 KCNQ1 INS IL6 CRP ALB
7	tangier disease	32.8	APOE APOB APOA1 ALB
8	lipoprotein quantitative trait locus	32.8	SERPINE1 NOS3 MIR210 MIR145 MIR143 KCNQ1
9	hypertension, essential	32.8	SERPINE1 NOS3 MIR210 MIR145 MIR143 KCNQ1
10	abdominal obesity-metabolic syndrome quantitative trait locus 2	32.7	SERPINE1 INS IL6 CRP APOB ADIPOQ
11	lipid metabolism disorder	32.7	SERPINE1 NOS3 INS IL6 CRP APOE
12	myocardial infarction	32.7	SERPINE1 NOS3 MIR210 MIR145 MIR143 KCNQ1
13	pericardium disease	32.7	IL6 CRP ALB ACE
14	cerebrovascular disease	32.6	MIR210 MIR145 MIR143 INS IL6 CRP
15	arteriolosclerosis	32.6	CRP APOE ALB ADIPOQ ACE
16	atherosclerosis susceptibility	32.5	SERPINE1 NOS3 INS IL6 CRP CDKN2B-AS1
17	peripheral vascular disease	32.5	SERPINE1 NOS3 INS IL6 CRP APOE
18	body mass index quantitative trait locus 11	32.5	SERPINE1 NOS3 MIR210 MIR143 MIR10A INS
19	hypercholesterolemia, familial, 1	32.5	NOS3 INS CRP APOE APOB APOA1
20	aortic aneurysm	32.4	SERPINE1 NOS3 MIR145 IL6 HIF1A-AS1 CRP
21	stroke, ischemic	32.3	SERPINE1 NOS3 INS IL6 CRP CDKN2B-AS1
22	angina pectoris	32.3	NOS3 INS IL6 CRP APOA1 ACE
23	congestive heart failure	32.3	KCNQ1 INS IL6 CDKN2B-AS1 ALB ACE
24	acute myocardial infarction	32.3	SERPINE1 NOS3 INS IL6 CRP CDKN2B-AS1
25	sleep apnea	32.3	SERPINE1 NOS3 INS IL6 CRP APOE
26	peripheral artery disease	32.3	NOS3 INS IL6 CRP CDKN2B-AS1 APOE
27	osteoporosis	32.2	SERPINE1 NOS3 MIR210 MIR145 MIR10A INS
28	arteriosclerosis	32.2	SERPINE1 MIR210 INS IL6 CRP APOE
29	dilated cardiomyopathy	32.2	NOS3 MIR10A KCNQ1 INS IL6 CRP
30	chronic kidney disease	32.2	NOS3 INS IL6 CRP APOB APOA1
31	apnea, obstructive sleep	32.1	NOS3 INS IL6 CRP APOE ALB
32	abdominal obesity-metabolic syndrome 1	32.1	SERPINE1 INS APOB ADIPOQ
33	aortic aneurysm, familial abdominal, 1	32.1	SERPINE1 NOS3 IL6 CRP CDKN2B-AS1 APOE
34	intermediate coronary syndrome	32.1	MIR145 INS IL6 CRP APOB APOA1
35	non-alcoholic fatty liver disease	32.1	SERPINE1 INS IL6 CRP APOB APOA1
36	kidney disease	32.1	SERPINE1 NOS3 INS IL6 CRP APOE
37	fatty liver disease	32.0	SERPINE1 INS IL6 CRP APOE APOB
38	pulmonary hypertension	32.0	SERPINE1 NOS3 MIR210 IL6 CRP ACE
39	hypertrophic cardiomyopathy	32.0	NOS3 KCNQ1 INS IL6 CRP ALB
40	familial hyperlipidemia	32.0	SERPINE1 INS CRP APOE APOB APOA1
41	pre-eclampsia	32.0	SERPINE1 NOS3 MIR210 INS IL6 CRP
42	arteries, anomalies of	32.0	NOS3 MIR210 MIR145 MIR143 MIR10A INS
43	heart valve disease	31.9	INS IL6 CRP ALB ACE
44	hypertriglyceridemia 1	31.9	SERPINE1 INS APOE APOB APOA1
45	hypothyroidism	31.9	SERPINE1 INS CRP APOE APOB APOA1
46	covid-19	31.9	NOS3 IL6 CRP ACE
47	hyperhomocysteinemia	31.9	SERPINE1 NOS3 CRP APOE ALB
48	nutritional deficiency disease	31.9	IL6 CRP ALB ADIPOQ
49	aortic dissection	31.8	NOS3 MIR145 MIR143 IL6 CRP ALB
50	microvascular complications of diabetes 5	31.8	SERPINE1 NOS3 INS ALB ACE

Graphical network of the top 20 diseases related to Cardiovascular System Disease:

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Symptoms & Phenotypes for Cardiovascular System Disease

MGI Mouse Phenotypes related to Cardiovascular System Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	10.1	ADIPOQ ALB APOB APOE IL6 INS
2	homeostasis/metabolism	MP:0005376	10.1	ACE ADIPOQ ALB APOA1 APOB APOE
3	renal/urinary system	MP:0005367	10.09	ACE ADIPOQ ALB APOE IL6 INS
4	liver/biliary system	MP:0005370	10.07	ACE ADIPOQ ALB APOA1 APOB APOE
5	neoplasm	MP:0002006	10	ACE ADIPOQ ALB IL6 MIR10A MIR217
6	adipose tissue	MP:0005375	9.87	ACE ADIPOQ APOE IL6 INS NOS3
7	endocrine/exocrine gland	MP:0005379	9.85	ACE ADIPOQ ALB APOA1 APOE IL6
8	cardiovascular system	MP:0005385	9.8	ACE ADIPOQ ALB APOA1 APOB APOE
9	immune system	MP:0005387	9.4	ACE ADIPOQ ALB APOB APOE CRP

Sources

Drugs & Therapeutics for Cardiovascular System Disease

Drugs for Cardiovascular System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 818)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dydrogesterone

Approved, Investigational, Withdrawn

Phase 4

152-62-5

9051

Norethisterone

Approved

Phase 4

68-22-4

199472 6230

Glyburide

Approved

Phase 4

10238-21-8

3488

Gliclazide

Approved

Phase 4

21187-98-4

3475

Rimonabant

Approved, Investigational

Phase 4

168273-06-1, 158681-13-1

104850

Torasemide

Approved

Phase 4

56211-40-6

41781

Dimethyl fumarate

Approved, Investigational

Phase 4

624-49-7

637568

Pravastatin

Approved

Phase 4

81093-37-0

54687

Fenofibrate

Approved

Phase 4

49562-28-9

3339

Atenolol

Approved

Phase 4

29122-68-7

2249

Carvedilol

Approved, Investigational

Phase 4

72956-09-3

2585

Lisinopril

Approved, Investigational

Phase 4

83915-83-7, 76547-98-3

5362119

Selenium

Approved, Investigational, Vet_approved

Phase 4

7783-07-5, 7782-49-2

533

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 4

1401-55-4

16129878 16129778

Amlodipine

Approved

Phase 4

88150-42-9

2162

Olmesartan

Approved, Investigational

Phase 4

144689-63-4, 144689-24-7

158781 130881

Vildagliptin

Approved, Investigational

Phase 4

274901-16-5

6918537

Amprenavir

Approved, Investigational

Phase 4

161814-49-9

65016

Telmisartan

Approved, Investigational

Phase 4

144701-48-4

65999

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Paroxetine

Approved, Investigational

Phase 4

61869-08-7

43815

Doxazosin

Approved

Phase 4

74191-85-8

3157

Ranolazine

Approved, Investigational

Phase 4

142387-99-3, 95635-55-5

56959

Medroxyprogesterone acetate

Approved, Investigational

Phase 4

520-85-4, 71-58-9

6279 10631

Hydroxychloroquine

Approved

Phase 4

118-42-3

3652

Cinacalcet

Approved

Phase 4

226256-56-0

156419

Dipyridamole

Approved

Phase 4

58-32-2

3108

Adalimumab

Approved, Experimental

Phase 4

331731-18-1

Racepinephrine

Approved, Vet_approved

Phase 4

51-43-4, 329-65-7

838 5816

Parathyroid hormone

Approved, Investigational

Phase 4

9002-64-6

Clonidine

Approved

Phase 4

4205-91-8, 4205-90-7

2803 20179

Salicylic acid

Approved, Investigational, Vet_approved

Phase 4

69-72-7

338

Ritonavir

Approved, Investigational

Phase 4

155213-67-5

392622

Insulin glargine

Approved

Phase 4

160337-95-1

118984454

Insulin detemir

Approved

Phase 4

169148-63-4

16137271

Lercanidipine

Approved, Investigational

Phase 4

100427-26-7

65866

Quinapril

Approved, Investigational

Phase 4

82586-55-8, 85441-61-8

54892

Manidipine

Approved, Investigational

Phase 4

89226-50-6

4008

Enfuvirtide

Approved, Investigational

Phase 4

159519-65-0

16130199

Nelfinavir

Approved

Phase 4

159989-64-7

64143

Nevirapine

Approved

Phase 4

129618-40-2

4463

Stavudine

Approved, Investigational

Phase 4

3056-17-5

18283

Indinavir

Approved

Phase 4

150378-17-9

5362440

Didanosine

Approved

Phase 4

69655-05-6

50599

Tipranavir

Approved, Investigational

Phase 4

174484-41-4

65027 54682461

Saquinavir

Approved, Investigational

Phase 4

127779-20-8

60787 441243

Lopinavir

Approved

Phase 4

192725-17-0

92727

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Paclitaxel

Approved, Vet_approved

Phase 4

33069-62-4

36314

Interventional clinical trials:

(show top 50) (show all 3966)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Ultra-low-dose Oral Versus Trans-dermal Hormone Therapy on Coagulation Activation and Metabolic Risk Factors for Cardiovascular Disease	Unknown status	NCT02264743	Phase 4	Femoston Conti;EVOREL® CONTI
2	SGLT-2 Inhibition and Cardiovascular Disease. Metabolomics Study of Potential Factors Involved in Cardio- and Nephroprotection	Unknown status	NCT03919656	Phase 4	Dapagliflozin 10 mg;Placebo Oral Tablet
3	A Morbi-Mortality and Remodeling Study With Valsartan in Patients With Hypertension and Cardiovascular Disease	Unknown status	NCT00133328	Phase 4	valsartan
4	Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients	Unknown status	NCT00247494	Phase 4	mycophenol mofetil (MMF, Cellcept®) 500 mg BID
5	Does Administration of Vitamin D in African Americans With Hypovitaminosis D and Type 2 DM Improve Inflammatory Markers of Cardiovascular Disease?	Unknown status	NCT01153243	Phase 4	Ergocalciferol;Placebo pill
6	Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines	Unknown status	NCT02797028	Phase 4	Allopurinol
7	Effects of Empagliflozin on Cardiac Structure, Function, and Circulating Biomarkers in Patients With Type 2 Diabetes	Unknown status	NCT02998970	Phase 4	Empagliflozin;Placebo
8	Effects on Incidence of Cardiovascular Events of the Addition of Pioglitazone as Compared With a Sulphonylurea in Type 2 Diabetic Patients Inadequately Controlled With Metformin.	Unknown status	NCT00700856	Phase 4	add-on pioglitazone;add-on sulphonylurea
9	Multi-centre Clinical Trial on Hormone Replacement Treatment in China	Unknown status	NCT01698164	Phase 4	estradiol plus MPA;Ximingting Tablet;estradiol plus progesterone
10	Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Stable Angina, NSTEMI and STEMI Undergoing PCI	Unknown status	NCT02012140	Phase 4	ticagrelor
11	Effect of Treating Sleep Apnea With Oral Appliances in the Elderly: ORACLE Study	Unknown status	NCT02325089	Phase 4
12	HOPE-2 Study (Heart Outcomes Prevention Evaluation-2 Study)	Unknown status	NCT00106886	Phase 4	Folic acid, vitamin B6 and B12 or placebo
13	A Randomized, Multicenter, Open, Parallel, Phase 4 Study to Compare the Efficacy and Safety Between High-intensity Rosuvastatin and Moderate-intensity Rosuvastatin/Ezetimibe in High ASCVD Risk Patients With Type 2 diabEtes (CREATE Study)	Unknown status	NCT03403556	Phase 4	Rosuvamibe;Monorova
14	Homocysteine Lowering and Atherosclerosis Reduction Trial (HART)	Unknown status	NCT00217178	Phase 4	Vitamins: Folic acid, B6, B12
15	Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease: a Randomized Clinical Trial	Unknown status	NCT01155128	Phase 4
16	Bedside Testing of the CYP2C19 Gene to Asses Effectiveness of Clopidogrel in Coronary Artery Disease Patients Treated With Percutaneous Coronary Intervention : Individualized Antiplatelet Drugs Treatment to Improve Prognosis	Unknown status	NCT01823185	Phase 4	clopidogrel;Ticagrelor or prasugrel
17	Randomized Clinical Study to Assess the Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias	Unknown status	NCT01717469	Phase 4
18	Early Detection of Atherosclerosis in the Primary Care Setting: a Randomized Trial to Assess the Efficacy of a Novel Strategy in the Primary Prevention of Cardiovascular Diseases.	Unknown status	NCT00734123	Phase 4	Simvastatin or Atorvastatin;Enalapril;Aspirin or clopidogrel;Rimonabant
19	Multicenter, Randomized Trial Designed to Evaluate the Applicability of the Guidelines of the Italian Society of Diabetology for the Prevention of Cardiovascular Diseases in Type 2 Diabetes	Unknown status	NCT01240070	Phase 4
20	Self-Assessment Method for Statin Side-effects Or Nocebo	Unknown status	NCT02668016	Phase 4	Atorvastatin
21	Clinical Study of UMOD NKCC2 Interaction on Salt-sensitivity in Hypertension	Unknown status	NCT03354897	Phase 4	Torasemide 5Mg Tablet
22	Levosimendan Versus Dobutamine in Cardiopatic Patients Undergoing Major Non Cardiac Surgery	Unknown status	NCT02012946	Phase 4	Levosimendan;Dobutamine
23	Effect of Hydroxychloroquine on Endothelial Function: a Clinical Trial	Unknown status	NCT04161339	Phase 4	Hydroxychloroquine;Placebo oral tablet
24	PPARGC1β And CNTN4 Genotype as a Pharmacogenetic Assay of Thrombosis and Bleeding Risks - a Cross-Over Controlled Trial of Aspirin in Individuals at Increased Cardiovascular Risk.	Unknown status	NCT02970604	Phase 4	Aspirin
25	Trial of Statin Holiday in Patients Receiving Maintenance Dialysis	Unknown status	NCT03663049	Phase 4	discontinue statin
26	Personalized Medicine in HCV Chronic Infection. Endothelial Dysfunction and Subclinical Atheromatosis in Patients With HCV Infection. Characterization and Potential Reversibility With Direct Antiviral Agents.	Unknown status	NCT02802280	Phase 4
27	The Influence of Adalimumab vs. Fumaric Acid Esters on Cardiovascular and Metabolic Risk Factors in the Therapy of Patients With Moderate to Severe Psoriasis Vulgaris	Unknown status	NCT01088165	Phase 4	Adalimumab treatment arm;Fumaric acid esters treatment group
28	Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease: An Interventional and Methodological Study	Unknown status	NCT00235287	Phase 4	Candesartan and enalapril;candesartan and enalapril
29	Hemocontrol's Effectiveness in a RAndomized Controlled Trial on the Reduction of Cardiovascular Long-term EventS	Unknown status	NCT01515878	Phase 4
30	Phase IV: A Comparison of Reduced-dose Prasugrel and Clopidogrel in Elderly Patients With Acute Coronary Syndrome Undergoing Early Percutaneous Coronary Intervention (PCI)	Unknown status	NCT01777503	Phase 4	prasugrel;Clopidogrel
31	Normal Oxygenation Maintenance in Intensive Care Unit: Randomized Controlled Trial	Unknown status	NCT01319643	Phase 4	Oxygen
32	Effectiveness and Safety of Low-dose vs. High-dose Rosuvastatin on Long-term Cardiovascular Events in Korean Patients After Percutaneous Coronary Intervention: 30-month, Prospective, Single-center, Randomized Trial	Unknown status	NCT02859480	Phase 4	Rosuvastatin 5mg;Rosuvastatin 20mg
33	Randomized, Double-blind, Cross-over Placebo-controlled Study to Assess the Functional Meat Products With n-3 and Rosemary Extract Fluid in Biochemical Markers of Cardiovascular Disease Related Risk in Subjects at Low Risk for Cardiovascular Disease	Completed	NCT01999088	Phase 4
34	A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors	Completed	NCT02019264	Phase 4	Lorcaserin hydrochloride;Placebo
35	Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease	Completed	NCT03038620	Phase 4	Liraglutide;Placebo
36	Effect of Omega-3 Supplementation on Serum Level and Gene Expression of IGF-1and IGFBP-3 in Men With Cardiovascular Disease.	Completed	NCT02092584	Phase 4
37	Effects of Punicalagin and Hydroxytyrosol Mixture on Different Inflammatory Markers Related With Cardiovascular Disease: a Crossover Study in Healthy Middle-aged Volunteers	Completed	NCT02042742	Phase 4
38	Impact of the PCSK9 Inhibitor Evolocumab on the Pharmacodynamic Effects of Clopidogrel in Patients With Atherosclerotic Cardiovascular Disease and High On-Treatment Platelet Reactivity	Completed	NCT03096288	Phase 4	Evolocumab
39	A Randomised Placebo-controlled Trial of Metformin on Progression of Carotid Atherosclerosis in Non-diabetic Patients With Cardiovascular Disease Treated With Conventional Risk Reducing Agents	Completed	NCT00723307	Phase 4	Metformin;Placebo
40	A Multi-center, Randomized, Open-label, Active-controlled, Phase IV Clinical Trial to Evaluate the Efficacy and Safety of OLOMAX Tab in Hypertension Patients With Low-Intermediate Risk for Cardiovascular Disease	Completed	NCT04120753	Phase 4	OLOMAX 20/5/5mg;OLOMAX 20/5/10mg;Olmesartan 20 mg/Amlodipine 5 mg
41	Multicentric Cross-over Trial to Assess the Glycemic Profiles on 8 Weeks of Vildagliptin and Sitagliptin Treatment, Each, in Type-2 Diabetic Patients With a Pre-existing Cardiovascular Disease Pre-treated With Insulin, Using a PROBE-design	Completed	NCT01686932	Phase 4	Vildagliptin;Sitagliptin
42	VIP: Vascular Imaging Project. Prospective Randomized Study on the Effect of AUC-monitored Treatment With Steroids Combined With Either a Calcineurin Inhibitor or Mycophenolate Mofetil on the Progression of Subclinical Cardiovascular Disease in Renal Transplant Recipients.	Completed	NCT00169910	Phase 4	AUC monitored withdrawal of MMF or CNI
43	A Pilot Study on Endothelial Function and Cardiovascular Biomarkers in Prostate Cancer (PCa) Patients, With Pre-existing Cardiovascular Disease, Treated With Degarelix vs. Luteinizing Hormone-Releasing Hormone (LHRH) Agonists	Completed	NCT02475057	Phase 4	Degarelix (LHRH antagonist);LHRH agonist
44	ONTARGET ONgoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial A Large, Simple Randomized Trial of an Angiotensin II Receptor Antagonist (Telmisartan) and an ACE-Inhibitor (Ramipril) in Patients at High Risk for Cardiovascular Events and TRANSCEND Telmisartan Randomized AssessmeNt Study in aCE iNtolerant Subjects With Cardiovascular Disease. A Parallel Study Comparing the Effects of Telmisartan With Placebo and Outcomes in Patients at High Risk for Cardiovascular Events and Intolerant to ACE-I.	Completed	NCT00153101	Phase 4	Telmisartan;Combination of Telmisartan and Ramipril;Ramipril
45	Interventions for Cardiovascular Disease: "Real-World" Effectiveness of Combined Pharmacotherapy and Behavioural Counseling for Smoking Cessation	Completed	NCT01623505	Phase 4	Champix;Transdermal Nicoderm patch combined with gum or inhaler;Transdermal Nicoderm patch
46	Effects of Valsartan on the Progression of Renal and Cardiovascular Disease - Kanagawa Valsartan Trial (KVT)	Completed	NCT00190580	Phase 4	valsartan;Conventional antihypertensive drugs
47	Subclinical Cardiovascular Disease in Psoriatic Disease	Completed	NCT03228017	Phase 4	Aspirin and/or Atorvastatin
48	A Trial of Telmisartan Prevention of Cardiovascular Disease	Completed	NCT01075698	Phase 4	Non-ARB (standard therapy);ARB (Telmisartan)
49	Reduction of Adolescent Risk Factors for Type 2 Diabetes and Cardiovascular Disease	Completed	NCT00934570	Phase 4	Metformin and standard exercise;Metformin Intensive exercise
50	A Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And Ibuprofen	Completed	NCT00346216	Phase 4	celecoxib;Ibuprofen;Naproxen

Search NIH Clinical Center for Cardiovascular System Disease

Cochrane evidence based reviews: cardiovascular diseases

Sources

Genetic Tests for Cardiovascular System Disease

Genetic tests related to Cardiovascular System Disease:

#	Genetic test	Affiliating Genes
1	Disorder of Cardiovascular System ²⁸	ACE
2	Abnormality of the Cardiovascular System ²⁸

Sources

Anatomical Context for Cardiovascular System Disease

Organs/tissues related to Cardiovascular System Disease:

MalaCards : Heart, Endothelial, Kidney, Spinal Cord, Adipocyte, Liver, Breast

Sources

Publications for Cardiovascular System Disease

Articles related to Cardiovascular System Disease:

(show top 50) (show all 32480)

#	Title	Authors	PMID	Year
1	Intracellular delivery strategies for microRNAs and potential therapies for human cardiovascular diseases. ⁴⁶	Shi MA...Shi GP	21045204	2010
2	MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. ⁴⁶	Fang Y...Davies PF	20624982	2010
3	Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. ⁵³ ⁶²	Blum S...Levy AP	20415560	2010
4	The role of FGF-23 in CKD-MBD and cardiovascular disease: friend or foe? ⁵³ ⁶²	Larsson TE	20124546	2010
5	The associations of interleukin-6 (IL-6) and downstream inflammatory markers with risk of cardiovascular disease: the Caerphilly Study. ⁵³ ⁶²	Patterson CC...Lowe GD	19836021	2010
6	Relationship of interleukin-6 with regional and global left-ventricular function in asymptomatic individuals without clinical cardiovascular disease: insights from the Multi-Ethnic Study of Atherosclerosis. ⁵³ ⁶²	Yan AT...Lima JA	20064818	2010
7	Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease. ⁵³ ⁶²	Nakayama T	20357747	2010
8	AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease. ⁵³ ⁶²	Li C...Keaney JF	20060780	2010
9	Association of interleukin-18 levels with global arterial function and early structural changes in men without cardiovascular disease. ⁵³ ⁶²	Vlachopoulos C...Stefanadis C	20075848	2010
10	Angiotensin II type 2 receptor gene polymorphisms in cardiovascular disease. ⁵³ ⁶²	Balmforth AJ	19861351	2010
11	The angiotensin II type 2 receptor in cardiovascular disease. ⁵³ ⁶²	Lemarie CA...Schiffrin EL	19861349	2010
12	Apelin and ACE2 in cardiovascular disease. ⁵³ ⁶²	Kalea AZ...Batlle D	20178040	2010
13	Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR. ⁵³ ⁶²	Horigan G...Scott JM	19952781	2010
14	The use of network analyses for elucidating mechanisms in cardiovascular disease. ⁵³ ⁶²	Diez D...Wheelock CE	20094647	2010
15	A new frame in thromboembolic cardiovascular disease: Adipocytokine. ⁵³ ⁶²	Amasyali B...Iyisoy A	18723235	2010
16	Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients. ⁵³ ⁶²	Lee SH...Kwon HS	19765773	2010
17	Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease. ⁵³ ⁶²	Lee J...Nordestgaard BG	19940276	2010
18	Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. ⁵³ ⁶²	Carty CL...Reiner AP	20059469	2010
19	Insulin therapy in type 2 diabetes: insulin analogue mix 50, a potential role in reducing postprandial hyperglycaemia and cardiovascular disease. ⁵³ ⁶²	Peter R...Evans LM	20001427	2010
20	Interleukin 18 and cardiovascular disease in HIV-1 infection: a partner in crime? ⁵³ ⁶²	Torre D...Pugliese A	20216908	2010
21	The yin and yang of cholesteryl ester transfer protein in cardiovascular disease. ⁵³ ⁶²	Shah PK	19948970	2009
22	Growth differentiation factor-15: a new biomarker in cardiovascular disease. ⁵³ ⁶²	Kempf T...Wollert KC	20024638	2009
23	Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. ⁵³ ⁶²	Vasan RS...Ordovas JM	19948972	2009
24	Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients. ⁵³ ⁶²	Bongers TN...Leebeek FW	19439298	2009
25	BK channels in cardiovascular disease: a complex story of channel dysregulation. ⁵³ ⁶²	Rusch NJ	19749161	2009
26	The emerging role of apelin in cardiovascular disease and health. ⁵³ ⁶²	Quazi R...Frishman WH	19829178	2009
27	Accuracy of plasma B-type natriuretic peptide to diagnose significant cardiovascular disease in children: the Better Not Pout Children! Study. ⁵³ ⁶²	Law YM...Silberbach M	19796740	2009
28	Adiponectin is associated with cardiovascular disease in male renal transplant recipients: baseline results from the LANDMARK 2 study. ⁵³ ⁶²	Kaisar MO...Isbel NM	19821969	2009
29	MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. ⁴⁶	Menghini R...Federici M	19786632	2009
30	Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: a prospective study. ⁵³ ⁶²	Colao A...Pivonello R	19622615	2009
31	Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease. ⁵³ ⁶²	Verdecchia P...ONTARGET/TRANSCEND Investigators	19770395	2009
32	Genetic determinants of cardiovascular disease: the renin-angiotensin-aldosterone system, paraoxonases, endothelin-1, nitric oxide synthase and adrenergic receptors. ⁵³ ⁶²	Gluba A...Rysz J	19779116	2009
33	Myeloperoxidase, subclinical atherosclerosis, and cardiovascular disease events. ⁵³ ⁶²	Wong ND...Berman DS	19761988	2009
34	Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly. ⁵³ ⁶²	Ingelsson E...Arnlov J	19339013	2009
35	Apolipoprotein B levels, APOB alleles, and risk of ischemic cardiovascular disease in the general population, a review. ⁵³ ⁶²	Benn M	19200547	2009
36	Potential for vitamin D receptor agonists in the treatment of cardiovascular disease. ⁵³ ⁶²	Wu-Wong JR	19371337	2009
37	Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease. ⁵³ ⁶²	Yamagishi S...Matsui T	19646657	2009
38	Enhancing cardiovascular disease risk reduction: raising high-density lipoprotein levels. ⁵³ ⁶²	Hausenloy DJ...Yellon DM	19574922	2009
39	P-selectin 1087G/A polymorphism is associated with neuropsychological test performance in older adults with cardiovascular disease. ⁵³ ⁶²	Gunstad J...Cohen RA	19590054	2009
40	Clinical impression of brain natriuretic peptide levels in demented patients without cardiovascular disease. ⁵³ ⁶²	Naito J...Watanabe H	19702933	2009
41	The roles of PON1 and PON2 in cardiovascular disease and innate immunity. ⁵³ ⁶²	Shih DM...Lusis AJ	19474728	2009
42	Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study. ⁵³ ⁶²	Carty CL...Reiner AP	19729864	2009
43	Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification? ⁵³ ⁶²	Schindhelm RK...Scheffer PG	19556446	2009
44	miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. ⁴⁶	Cordes KR...Srivastava D	19578358	2009
45	Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia. ⁵³ ⁶²	Oeffinger KC...Vega GL	19564534	2009
46	The status of glutathione peroxidase, superoxide dismutase, vitamins A, C, E and malondialdehyde in patients with cardiovascular disease in Zahedan, Southeast Iran. ⁵³ ⁶²	Karajibani M...Dikshit M	19763031	2009
47	Cardiovascular disease risk in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. ⁵³ ⁶²	Kim MS...Merke DP	19530065	2009
48	Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease. ⁵³ ⁶²	Fruchart JC	19386311	2009
49	Vitamin D deficiency and risk for cardiovascular disease. ⁵³ ⁶²	Judd SE...Tangpricha V	19593102	2009
50	Oral hypoglycaemic agents, insulin resistance and cardiovascular disease in patients with type 2 diabetes. ⁵³ ⁶²	Hemmingsen B...Vaag A	19369429	2009

Sources

Genes for Cardiovascular System Disease

Genes/enhancers related to Cardiovascular System Disease (3 elite genes):

(show top 50) (show all 210)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	KCNQ1	Potassium Voltage-Gated Channel Subfamily Q Member 1	Protein Coding	410.42	Pathogenic ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9564764 16132053
2	MIR210	MicroRNA 210	RNA Gene	361.78	Causal ⁴⁶ DISEASES inferred ¹⁴ ¹⁴	18417479
3	ACE	Angiotensin I Converting Enzyme	Protein Coding	120.62	Genetic Tests ²⁸ DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16476718 17875946 14704227 (more) 11256587 8743524 11344778 17504232 16924268 10874503 16222900 17898539 8591889 1414888 19290794 17103020 11986905 19491618 15161784 12643119 9747149 15567997 15332219 12818733 12676161 11401108 11071385 10483967 9786099 8768273 15868120 7713109 19221299 9143778 15215792 14608518 11288962 19770395 1562174 8886509 9327710 9677696 9736776 9808697 10354208 11059628 14707162 12873287 12669427 12661913 12519409 11498459 11401071 11345362 11228171 7602784 7739115 7856275 7965262 1381783 2344816 20019467 7955173 20066135 12710862 12220962 11882622 11835905 10876800 10695707 10639547 9868993 9752816 19888787 17199216 19878370 18084312 18449379 18383770 17885543 17243909 16769256 11142763 10999650 10821349 10520809 10351920 10794598 9717054 9120994 8877073 8872813 8773433 8903616 8065033 7512465 1290308 16444043 16921734 16462911
4	CDKN2B-AS1	CDKN2B Antisense RNA 1	RNA Gene	157.24	Experimental evidence: Mutation ³⁷ DISEASES inferred ¹⁴	20716961 22382030 23104877 (more) 24113581 24531795
4	CDKN2B-AS1::GH09J022124	TSS distance: +130.6kb Elite enhancer			Curated enhancer-disease association ²³ ¹³	25744911
5	HIF1A-AS1	HIF1A Antisense RNA 1	RNA Gene	155	Experimental evidence ³⁷ DISEASES inferred ¹⁴	25761653
6	NPPA-AS1	NPPA Antisense RNA 1	RNA Gene	154.37	Experimental evidence ³⁷ DISEASES inferred ¹⁴	22817756
7	MIR145	MicroRNA 145	RNA Gene	61.5	Unspecified ⁴⁶ DISEASES inferred ¹⁴ ¹⁴	19578358
8	MIR143	MicroRNA 143	RNA Gene	61.06	Unspecified ⁴⁶ DISEASES inferred ¹⁴ ¹⁴	19578358
9	MIR10A	MicroRNA 10a	RNA Gene	60.39	Unspecified ⁴⁶ DISEASES inferred ¹⁴ ¹⁴	20624982
10	MIR217	MicroRNA 217	RNA Gene	55.58	Unspecified ⁴⁶ DISEASES inferred ¹⁴	19786632
11	INS	Insulin	Protein Coding	21.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15717879 15660727 17420421 (more) 7652727 15208835 16980199 16334591 18974244 14764276 17023708 15159251 9590566 20001427 19114407 14976002 9861517 8462390 1736105 18309108 17954428 16506274 14968294 12627878 18779682 16581078 9240771 19138313 16259222 12957327 16054467 9100707 17368007 1457758 7981184 10707556 9270410 8856394 12150695 12692007 19015938 18775353 18640389 17873318 17320517 17183416 17218834 15998260 15579783 16820727 16392771 16319655 14647894 14553866 11997182 14739074 12647277 12408408 12365467 10821297 10440591 10374288 8299479 19149565 7828781 2065046 19572942 19421860 19564534 18927552 18296327 17826042 17760500 17259501 16522281 15075712 12877091 12702035 12675638 8949974 19731182 19164269 17952838 16839860 15590982 14626524 12610050 12540621 12148078 10024191 8964200 7782801 20513276 19369429 19214921 18772854 16697386 17181562 15258201 15047659
12	CRP	C-Reactive Protein	Protein Coding	21.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15529024 12823355 18855714 (more) 10393687 16905938 11849404 12943870 18060926 19667982 10569656 19240794 17584093 17220790 14742804 14566035 16431250 15148294 17266610 11238289 10192648 17276184 17203810 15585211 15955978 20206126 19690638 17973918 18677173 17044846 12620166 10764673 16939632 16534007 15811980 14709450 18952164 19329405 17893410 17511977 17174735 16901413 16265340 15205370 15147103 16238678 18702945 18300125 19228486 17055707 17283264 17077623 15505005 11926788 10229731 9727541 9351386 18691271 19365169 19075099 17551260 12186793 16125489 19423845 15078802 10590187 11950696 12006917 12850240 14625121 15184288 15323255 15900306 15975559 15857269 15791030 15722558 15668660 15284086 15467191 15451155 17949793 18294231 18262272 17342166 17878255 18163969 17637303 17310862 16958597 10807156 20123638 20234030 19808911 19243779 18501446 19398609 19426506 18289549 17716549
13	APOB	Apolipoprotein B	Protein Coding	19.27	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18560450 18220807 19168552 (more) 19200547 17953518 10961094 11883334 19456221 12547700 15955978 17890784 18333887 18498273 19068318 19497316 10588084 12297895 12492446 12649091 15277429 15843229 16798966 11995245 11006895 9651904 9636203 8546746 2123624 19952033 16432543 16629852 17672218 14770189 12624282 9846102 7652481 2163516 19355857 18720348 17234819 17170368 17277465 16257193 17002798 15716585 14746139 12447639 15805152 15047470 18633759 17701049 18277343 17969379 17631073 17030687 19051333 16281487 16034221 19829109 18958843 18607182 17544386
14	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	19.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18027814 17253436 16581078 (more) 19389061 19261992 15780820 19906806 17101706 17873318 18336252 17161223 19227810 18241619 17145218 16324920 15827100 15589686 19821969 18387655 19245516 19159917 18029194 19675525 17646605 17572841 17140553 17142348 16219717 19857072 12660876 15132729 15502925 18191060 18344634 16210704 15761179 15070917 20154470 19640365 19371199 19106327 18632660 18762168 15569472 15168385 11344187 19874712 18591880 18989258 18798447 18594137 19773737 15670203 15114523 20096841 19845523 20066136 19172446 19359049 19157250 18472407 14633805 14627760 14592564 12914718 18362426 18084018 17457380 17633232 16756736 16320084 17970534 18593221 17645557 17224001 17391153 16427606 16939660 16464169 19223612 19136982 18434424 18069030 18370712 17893263 17950098 17322479 17495599 17003095 17215175 16231029 16202556 16973279 16551729 15616802 17303804 17505621 17030960 17046559
15	ALB	Albumin	Protein Coding	19.14	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1553966 7606307 9229197 (more) 1353802 8862223 19150611 15956113 16377395 8273237 9612878 16178477 10800280 16980573 9662051 8427856 10419073 11422658 11849464 8504630 16429841 11849404 11845230 10922975 10898045 10446083 9767548 9416983 7485062 10809241 10335721 10333909 9686391 8086657 8243884 8478855 19609391 19460474 12356649 11982822 11941273 11574957 10886588 10580435 9179466 7922240 8105164 11157375 10872702 9389420 9226225 8785388 8546125 7629407 2168768 16238681 11294805 9573549 9349601 8140398 8345490 1993322 20189274 20016051 20098471 19145004 19028824 17159023 15962607 15177126 12969166 11431186 18790809 18337481 18558299 16280473 15125372 12690921 12606536 12460872 8481551 1625684 2142055 19915481 19450204 18834870 12389063 10817400 19093915 18617580 18394058 18596379 18487797 17875308 16580621 16413943 12163426 2137750 12703884 15198838
16	IL6	Interleukin 6	Protein Coding	19.03	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	20064818 15784406 20059469 (more) 20203323 12943870 16467451 15854959 16377395 17596140 15090695 18034847 16087797 11230284 19936194 8607801 11887976 15882283 15876998 17665966 9583349 16472051 15955978 15663921 15179102 15136493 15070917 14962637 12788842 10695556 19669729 18347604 18928156 18781928 18296371 18195475 18091699 17194638 16313298 15590982 15205588 15161792 12846758 9125293 20164544 19509100 17970534 17852073 11677362 20129796 19439300 19223201 19608012 17879575 17684929 17335789 17242212 15078584 14978155 14671050 12637697 11766356 19913852 16797387 16216472 15756217 15364891 12544661 11230338 11114578 19702114 18449539 18274928 17196470 16839861 16960028 16458279 15705924 15753186 17911176 17878722 17687823 17404162 17132648 16900203 16464786 16360159 12163427 19836021 19319930 18195193 18257336 18179502 17698692 17322479 20515802 19903755 19744034 17059420 15604420
17	SERPINE1	Serpin Family E Member 1	Protein Coding	18.76	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18050673 9187410 10695479 (more) 16039281 10648020 16126968 15311550 18600083 20205861 11567663 14995993 11567664 14678868 8060375 11278457 12728597 16477805 15919609 15380459 14963283 14553864 10208482 10064006 9843166 19918669 17850750 12871373 15080492 11733024 11179976 11129405 10520809 10364094 10980830 9498632 14605330 12911596 12719278 12734779 12195702 11816701 11522017 11373350 10798278 9041098 9005966 16789641 15988701 11092431 11057874 10831181 9734732 9423801 9198234 18501910 15820196 14746139 12891381 11372681 10452346 9622268 18624608 17161063 16128865 12911589 11588944 11525072 10417403 9805421 9161416 9258409 19889809 18559377 17970534 18593221 16427606 15630497 14993864 9048903 9031456 8831916 18191049 17014002 15901895 15379715 12921488 7698502 7813812 8241103 8462390 19888787 19132219 16939632 16522281 16091487 15575342 12723974 12540956 11197396
18	NOS3	Nitric Oxide Synthase 3	Protein Coding	18.65	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17108813 19407804 18331440 (more) 15494775 18349107 20082095 18617528 10393506 16845178 16418168 11692081 12716763 18086002 9806747 15790928 18079690 18713021 17496167 17382196 17082313 16873694 16492203 15890550 15565175 11129410 10600037 18200826 17018701 16060860 14576373 12142730 11849440 11431031 9461225 9314409 15712782 15255799 12503100 11595733 11693755 10484073 20350698 19605523 17584103 19505886 18252813 17399719 16113535 15091109 11720085 11707686 10781649 10442857 19376104 19077211 17264164 16170835 16093452 16231020 16502366 16585403 15636445 15211444 12364322 20422736 18551994 19486510 18692595 15123766 14675775 12837457 12586536 12381413 20213497 18640391 18230825 17243909 10543322 9564764 19463074 16531750
19	APOA1	Apolipoprotein A1	Protein Coding	18.64	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15314690 16901406 15498770 (more) 17234819 16798073 16452169 18388068 19456221 20178050 12471038 19237735 18277343 17969379 17631073 17699012 16368749 16030277 1451121 19800416 18565099 17699011 14746139 12573361 11313781 11006895 9987089 8943493 8546746 2123624 19068270 19055467 16187691 12417283 11827556 9915567 7615839 19355857 19952033 18702334 17240315 15574409 11943562 10646643 7767918 18519851 16798966 17298957 18333887 19179308 20196736 8400337 12957326
20	APOE	Apolipoprotein E	Protein Coding	18.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16161810 8867586 12015945 (more) 15653176 11807900 20074603 11257253 9801016 8557181 8198763 9693262 10428303 10632725 12850485 17662693 18378224 15374172 9564764 11120871 11814460 12182119 12190886 15505371 16955690 17676504 17426996 18562290 18156097 17911980 16644874 15276651 12196500 11177205 10655544 8399082 10406818 9706883 9611077 9238027 19891383 19252179 17462871 16817024 16786033 11369364 10620569 20429872 20019593 17763167 17332893 17240315 16282567 16815851 11882522 11106322 9472879 9012642 1947727 19636906 18298348 17715945 17684217 17308333 16815257 16106048 15830139 14746139 12573381 12473848 12086087 15780204 15585780 12796755 12739024 12544661 11470126 10754375 10587578 16013355 15935014 15226466 12473860 11891412 10851367 19943806 19641010 7497860 18320120 16671834 17702862 17044846 16266401 18376080 1911720 8782820 10553197 10094101 10818513 11803456
21	REN	Renin	Protein Coding	18.06	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19410337 19278599 1759997 (more) 7516858 2110974 12692747 20010781 15983245 9226225 8293766 18237679 9120665 20041594 18611061 18221088 12676161 12431022 11953098 18764720 15526242 10903938 8615291 2232318 19715410 8573547 18340340 7983230 14728059 8877073 7965262 8788503 12927775
22	EDN1	Endothelin 1	Protein Coding	18.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17617392 20217138 19057845 (more) 11078363 8981573 9546947 10077237 10877200 11078425 17164035 18288492 19111553 19150882 19506099 20083432 20491339 7916401 9176309 10434349 11005584 11425780 8971583 8752200 17827914 16809937 12143942 11811378 10976779 9591497 8904934 18555838 16248779 12686474 11869173 11566914 9110115 19967386 19779116 18062774 17019099 16101562 12688403 12236017 10651255 9595409 8160238 18047620 17580594 19564455 16787211 11811372 11411770 10949163 9494073 9409267 9354313 9093521 16505174 15018244 11953098 11725953 11385185 10065339 9859740 9381781 19907721 18954524 18675382 17965745 15257257 14655103 14597580 12616854 11419917 10494802 9449382 20339975 12839265 14748289 16740999
23	LEP	Leptin	Protein Coding	17.95	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18926322 10583712 10757633 (more) 17161223 18431365 10334326 17007277 19001191 15702617 16261186 15292320 15202616 18387655 9933268 11997182 20174754 16335797 12370213 14699970 14514596 12880566 19571581 18574061 17322479 17175979 17210981 16116494 15937081 20066136 19172446 19148833 19112726 17970534 16940932 15886225 15331885 15117839 20458445 19132788 18959828 18832901 18160070 17872473 16648622 16720637 12903905 11935372 18820649 18651469 17207790 17240315 15827100 12647279 19944469 15234549 14871050 14749504 12190889 18474180 16362081 16404479 15927298 18726825 16320084 15670203 15375794 15072562 12872039 12423321 11472752 14615386 14629465 12674182 11795261 19846168 18723235 18195475 16712853 20125099 19584182 18775082 17878255 16735961 15919793 15968576
24	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	17.9	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9449684 9702074 9740630 (more) 16519598 7713122 12518185 18182232 10738546 11134677 18360014 16274774 8613189 19330904 16504375 7713099 19475773 16732715 17146658 18422392 16121033 14654250 11707686 11106322 10937949 9717050 8773261 17305412 10351920 19888787 10876800 8993854
25	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	17.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15962651 10912119 11228171 (more) 15922259 16185099 17242008 17493470 19848438 19791839 20190699 10090116 11684078 11772284 15598024 17209661 17392488 17520093 18158500 17927279 18700910 19224538 19940267 11057120 12921488 16921390 17174224 18506803 19318042 20005478 10860000 12002257 12745170 16034478 16581326 19376844 16185181 14727946 14742804 12815379 19804261 18622257 18366980 17293685 16803418 16849890 17608248 18332269 18473714 18540668 19254829 15320474 15449961 15472596 16503718 15836008 17563259 18200826 18457539 9694549 10091528 11164838 12390056 16113468 16871575 18261733 11030795 11477342 12752842
26	VWF	Von Willebrand Factor	Protein Coding	17.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19439298 10648020 11887976 (more) 15755826 16322530 16449948 20008188 12370220 12792699 15380459 16236894 17507174 9498659 10580169 12563218 12921488 19029465 2142055 17555832 8118478 16158039 16095049 15662616 17598011 16807651 15562207 12911589 12399074 11426020 7491837 12945874 17132648 19506354 7972262 11427638 16458279
27	TNF	Tumor Necrosis Factor	Protein Coding	17.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17705580 15854959 12943870 (more) 11453575 10433867 12191598 11887976 15692810 18487876 9530222 10695556 15179102 16472051 11997182 20443835 20016776 19736814 19012050 19118493 18673161 18370712 18257336 18273720 17883332 17663929 17377521 16150792 16243340 12873047 11566619 18928156 16797387 16260427 15893134 15257473 15122056 12914718 12006640 11114578 17328057 19729864 19641672 16456090 16224057 15246652 12517724 11007832 10707566 20009917 16174491 11693755 19913852 17849692 16840748 16320084 15753186 15159291 12843690 11744409 19509100 18418430 18781928 18195475 17356550 16636217 16857167 15808915 15084512 14514596 15996054 15663921 11846495 9990527 18814905 15784406 16218487
28	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	17.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19129679 15320743 20158101 (more) 18417957 11872377 14732733 16335797 16556873 12663371 16360030 19646657 11374025 19228871 18580862 18370623 18288288 16831022 14566384 19796634 18552452 19808901 19515415 19490202 18308193 18241614 18071073 18001313 16563944 15117825 19117570 18220629 18288291 17076999 11861659 12957321 10408502 19569080 17240171 15830032 15234647 14521714 12861348 18173954 15142970 19620300 17164134 16696956 18922179 19118492
29	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	17.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15561486 15837084 17899317 (more) 12499324 11058711 15494775 10428303 11481907 12927690 16531750 16958597 9051203 10926884 11433922 11916749 14728017 11532106 9510851 8873653 8554066 15226189 15073633 11692165 15889539 14577615 12544661 11287760 10512925 9774778 9583842 9130949 15583437 19609317 17976958 12370778 11749660 10781649 8940272 19952781 19376104 11683544 11406421 9974399 17240315 16605249 16634455 16046727 11419077 10408794 9868588 18840629 19882941 17917766 15735068 12196500 11274026 10329022 9327760 11168432 12146133 12356947 16602021
30	NPPB	Natriuretic Peptide B	Protein Coding	17.03	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19702933 9093047 9286500 (more) 17210472 12239593 17257357 16958597 16011727 18356635 15325948 16330398 17426794 9366809 17266610 18307738 16105071 18552579 12633801 8877790 16599827 16221702 15983245 10562924 8613267 19796740 18362428 16784419 16344502 15385748 11558683 8952587 8282365 19815605 18039187 16623357 16538971 16234898 19387249 18058731 16585413 12681464 12422152 12225726 8083346 20040348 19396053 18632852 18588432 16092582 16352258 16601459 15887397 15643118 9095445 16893713 14987578 12381941 19760573 19917883 17536606 19274732 19631175 16633992 18394002 18420944 17375888 17244121 18505615 17340039 18620103
31	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	17.03	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18034623 18288280 15503647 (more) 16316298 19318113 17360982 18799592 18401448 11698662 10934348 17145061 16106185 16511589 18586686 18628776 17169249 17237841 16484544 18436144 18173954 17496434 17194889 11864924 20446588 20005515 19515415 18509489 18241614 17413033 17307056 14501584 19386311 18311660 16672917 10408502 18420459 18221086 17363837 11374025 19822141 17593234 12570700 16116345 15142970 19500491 18336366 12163127 15528894 17935055
32	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	16.88	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19566488 15030267 15627719 (more) 11919402 12818967 18257336 12640339 18328350 15122056 19781803 19014891 18579536 16814297 20009917 15520826 19068240 18339698 20140679 16099464 17665966
33	MIR199A1	MicroRNA 199a-1	RNA Gene	16.87	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
34	PON1	Paraoxonase 1	Protein Coding	16.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18355454 15990587 19474728 (more) 19201174 17977159 12525679 9746266 10411705 12618279 15166781 15243212 15375178 15458977 16438805 17712585 17915616 17301599 15251338 15016430 14505812 11803456 16681435 19550323 18796237 19779116 19082953 17971175 17359486 16926679 14998248 14579013 12909569 10462749 16112460 15576850 12489064 9240427 20002083 19318033 18704198 17598371 16517986 20112598 19319852 18608549 17032345 15613429 15670573 7564664 19151417 18164014 15454270 15023811 12204423 10373401 9011577 20348046 20332543 19540141 18830558 19371607 16120573 12196500 20362697 18281420 17512573 17692153 18349088 10898114 11151764 15336559 15642273 16540037 17651311
35	CETP	Cholesteryl Ester Transfer Protein	Protein Coding	16.68	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15939053 18243217 18620517 (more) 17257272 17257461 15856070 7583564 12691171 16439711 18646836 19436720 19948970 18957472 17784782 17440012 17531380 20465364 20297868 17409111 16226917 15324321 12639975 11888533 18468607 18503096 18509195 18607187 18518852 17196207 15450208 19085339 17852818 17277799 16503868 15681846 15738977 18287799 17949364 16861609 12889988 17237796 19948972 12376088 14559957 15857309
36	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	16.62	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10648020 15692257 12891381 (more) 8528854 16126968 14983217 16796017 17404162 16807651 18953568 12463111 11372681 7996060 19889809 15901895 15379715 12921488 10207029
37	RETN	Resistin	Protein Coding	16.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18220599 17175295 18446183 (more) 19223612 11994397 17003095 18195475 19740705 18723235 15710760 17970534 19639497 15670203 16104844 16515776 17498119 19454585 19828833 19940327 12874180 12914718 16159596 17302872
38	SELP	Selectin P	Protein Coding	16.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11726042 16449250 12370220 (more) 15136493 17598012 20193033 19300046 19590054 17687823 14659768 19232335 10775025 12399074 15683111 19691482 11597943 9529262 12911583
39	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	16.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17610342 11353578 17409575 (more) 19114086 15018246 15171358 14608520 18174920 19541744 19337952 15945295 15808807 15824460 20226957 15860254 15554912 15218387 18729003 19307693 19168055 15947887 17234708 19590161 18277151 19804189 15257862 16286565 16879778
40	SELE	Selectin E	Protein Coding	16.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11726042 16322530 19171188 (more) 19903755 11051283 12640339 14652631 18591880 9242960 12945874 14675775 19509100 14988255 17397316 10449693 20009917 20191078 11172623 15833936 17555832
41	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	16.05	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11726042 17148932 18225982 (more) 18504269 20193033 16332659 20009917 16564549 20368209 11172623 17397316 15257473 12640339 18296371 10409552
42	LPA	Lipoprotein(A)	Protein Coding	15.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7857388 9693262 10751199 (more) 1345006 9051192 19307470 20196736 8400337 15003733 8329699 7819711 17541022 11122750 11882522 19636317
43	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	15.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15262183 16183915 17093293 (more) 16446539 12615648 18541924 16806540 12236582 16879828 16235041 12407001 19783654 11927274 17383594
44	AGT	Angiotensinogen	Protein Coding	15.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11345362 16033904 16531750 (more) 16513650 16908765 11751722 8695029 18675382 19348233 16969748 7713099 7713117 11228750 17489676 9793075 10703882 17975262 12806586 19669395
45	KNG1	Kininogen 1	Protein Coding	15.7	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11975815 17212359 16023651 (more) 10952948 17716647 16387685 19628666 11233272 11694220 7713109 11281230 11288962 11355044 9680670 11881101
46	CST3	Cystatin C	Protein Coding	15.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17996317 16838182 16609294 (more) 20207770 20008829 16908914 18508621 19374014 20082582 14628480 14726415 18704820 19357259 17998494 17394021 17234172 17289743 17234819 15809461 18378946 18787643 20233980 18187137 18480203 19765773 16712749 17429295 18940290 19622349 17205961
47	LPL	Lipoprotein Lipase	Protein Coding	15.37	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17803213 9498535 9662394 (more) 12652096 12691171 9081692 20350420 16574898 9846102 17484619 11073182 19052449 10406818 20429872 10636447 16106048
48	CBS	Cystathionine Beta-Synthase	Protein Coding	15.27	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17553479 8554066 9919468 (more) 10336241 9466825 11406421 12529702 11528503 10807759 11351038 19733148 8165688
49	PDE5A	Phosphodiesterase 5A	Protein Coding	15.08	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15083994 16409215 18040025 (more) 16387566 20101899 16156423 16387565 18953278 16018863 16387575 17017939 16387567 16036043 15574127 11351772 16185664 15115192 18674473 14609621
50	THBD	Thrombomodulin	Protein Coding	14.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1725416 11919402 14624417 (more) 15755826 12921488 12945874 16456088 10231031 15869594 16095049 19609862 17677000

Sources

Variations for Cardiovascular System Disease

ClinVar genetic disease variations for Cardiovascular System Disease:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	KCNQ1	NM_000218.3(KCNQ1):c.733_734del (p.Gly245fs)	DEL	Pathogenic	438610	rs1554893092	GRCh37: 11:2593291-2593292 GRCh38: 11:2572061-2572062

Sources

Expression for Cardiovascular System Disease

Search GEO for disease gene expression data for Cardiovascular System Disease.

Sources

Pathways for Cardiovascular System Disease

Pathways related to Cardiovascular System Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	11.72	IL6 APOE APOB APOA1 ALB
2	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.59	INS IL6 ADIPOQ
3	Adipogenesis ⁷⁴	11.57	SERPINE1 INS IL6 ADIPOQ
4	Statin inhibition of cholesterol production ⁷⁴ Show member pathways Familial hyperlipidemia type 3 ⁷⁴ Lipid particles composition ⁷⁴ Statin Pathway, Pharmacodynamics ⁶⁰	11.46	APOE APOB APOA1
5	miRNAs involved in DNA damage response ⁷⁴	11.37	MIR210 MIR145 MIR143
6	Nonalcoholic fatty liver disease ⁷⁴	11.16	INS IL6 ADIPOQ
7	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	11.07	INS APOA1 ALB
8	Binding and Uptake of Ligands by Scavenger Receptors ⁶⁶ Show member pathways Scavenging by Class A Receptors ⁶⁶ Scavenging by Class B Receptors ⁶⁶ Scavenging by Class F Receptors ⁶⁶ Scavenging by Class H Receptors ⁶⁶ Scavenging of heme from plasma ⁶⁶	10.88	APOE APOB APOA1 ALB

Sources

GO Terms for Cardiovascular System Disease

Cellular components related to Cardiovascular System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	10.03	INS IL6 APOE APOB APOA1 ALB
2	high-density lipoprotein particle	GO:0034364	9.85	APOE APOB APOA1
3	very-low-density lipoprotein particle	GO:0034361	9.8	APOE APOB APOA1
4	intermediate-density lipoprotein particle	GO:0034363	9.71	APOE APOB
5	extracellular space	GO:0005615	9.68	SERPINE1 MIR210 MIR143 MIR10A INS IL6
6	endocytic vesicle lumen	GO:0071682	9.63	APOA1 APOB APOE
7	chylomicron	GO:0042627	9.43	APOE APOB APOA1

Biological processes related to Cardiovascular System Disease according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	10.24	KCNQ1 INS CDKN2B-AS1 APOE ACE
2	negative regulation of inflammatory response	GO:0050728	10.05	MIR145 APOE APOA1 ADIPOQ
3	vasodilation	GO:0042311	10.01	APOE INS NOS3
4	acute-phase response	GO:0006953	10	INS IL6 CRP
5	cholesterol efflux	GO:0033344	9.91	APOE APOB APOA1
6	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.88	NOS3 MIR210 MIR143
7	positive regulation of cholesterol efflux	GO:0010875	9.88	APOE APOA1 ADIPOQ
8	positive regulation of cholesterol metabolic process	GO:0090205	9.87	APOE APOA1
9	lipoprotein catabolic process	GO:0042159	9.85	APOE APOB
10	positive regulation of dendritic spine maintenance	GO:1902952	9.8	APOE INS
11	positive regulation of phospholipid efflux	GO:1902995	9.78	APOA1 APOE
12	negative regulation of angiogenesis	GO:0016525	9.76	MIR217 MIR145 MIR143 MIR10A
13	positive regulation of lipid biosynthetic process	GO:0046889	9.73	INS APOE APOA1
14	lipoprotein metabolic process	GO:0042157	9.62	APOA1 APOB APOE
15	aorta smooth muscle tissue morphogenesis	GO:0060414	9.56	MIR145 MIR143
16	negative regulation of smooth muscle cell proliferation	GO:0048662	9.43	NOS3 MIR145 MIR143 APOE
17	regulation of phenotypic switching	GO:1900239	9.37	MIR145 MIR143
18	establishment or maintenance of cell type involved in phenotypic switching	GO:0044663	9.16	MIR145 MIR143
19	lipoprotein biosynthetic process	GO:0042158	9.1	APOE APOB APOA1

Molecular functions related to Cardiovascular System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	low-density lipoprotein particle receptor binding	GO:0050750	9.63	CRP APOE APOB
2	phosphatidylcholine-sterol O-acyltransferase activator activity	GO:0060228	9.62	APOE APOA1
3	lipid transporter activity	GO:0005319	9.56	APOE APOB APOA1
4	cholesterol transfer activity	GO:0120020	9.43	APOE APOB APOA1
5	mRNA base-pairing translational repressor activity	GO:1903231	9.02	MIR217 MIR210 MIR145 MIR143 MIR10A