MCID: CRL006
MIFTS: 27

Caroli Disease, Isolated

Categories: Fetal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Caroli Disease, Isolated

MalaCards integrated aliases for Caroli Disease, Isolated:

Name: Caroli Disease, Isolated 57
Caroli Disease 59 72

Characteristics:

Orphanet epidemiological data:

59
caroli disease
Inheritance: Autosomal recessive,Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: All ages;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
caroli disease, isolated:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 600643
MESH via Orphanet 45 C531647 D016767
ICD10 via Orphanet 34 Q44.6
UMLS via Orphanet 73 C0162510 C1833541
Orphanet 59 ORPHA53035
MedGen 42 C1833541
UMLS 72 C0162510

Summaries for Caroli Disease, Isolated

MalaCards based summary : Caroli Disease, Isolated, also known as caroli disease, is related to polycystic kidney disease 4 with or without polycystic liver disease and caroli disease. An important gene associated with Caroli Disease, Isolated is PKHD1 (PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin). Affiliated tissues include liver, kidney and lung, and related phenotypes are hepatomegaly and portal hypertension

More information from OMIM: 600643

Related Diseases for Caroli Disease, Isolated

Diseases related to Caroli Disease, Isolated via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 polycystic kidney disease 4 with or without polycystic liver disease 11.6
2 caroli disease 11.4
3 cholangitis 10.5
4 portal hypertension 10.4
5 congenital hepatic fibrosis 10.4
6 cholangiocarcinoma 10.4
7 intrahepatic cholangiocarcinoma 10.4
8 polycystic kidney disease 10.3
9 kidney disease 10.2
10 polydactyly 10.1
11 choledocholithiasis 10.1
12 end stage renal failure 10.1
13 autosomal dominant polycystic kidney disease 10.1
14 splenomegaly 10.1
15 ciliopathy 10.1
16 renal dysplasia 10.1
17 pneumothorax, primary spontaneous 9.9
18 polydactyly, postaxial, type a1 9.9
19 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
20 bile duct cysts 9.9
21 nephronophthisis 3 9.9
22 cholangitis, primary sclerosing 9.9
23 nephronophthisis 13 9.9
24 autosomal recessive disease 9.9
25 polycystic liver disease 9.9
26 arteriovenous malformation 9.9
27 constrictive pericarditis 9.9
28 primary biliary cirrhosis 9.9
29 nephronophthisis 9.9
30 cholestasis 9.9
31 sclerosing cholangitis 9.9
32 pneumothorax 9.9
33 pericarditis 9.9
34 acute pancreatitis 9.9
35 adenocarcinoma 9.9
36 papillary adenocarcinoma 9.9
37 liver disease 9.9
38 liver cirrhosis 9.9
39 congestive heart failure 9.9
40 situs inversus 9.9
41 chronic kidney disease 9.9
42 lung disease 9.9
43 amyloidosis 9.9
44 amyloidosis aa 9.9
45 encephalocele 9.9
46 hepatic cystic hamartoma 9.9
47 primary biliary cholangitis 9.9
48 renal dysplasia diffuse cystic 9.9
49 occipital encephalocele 9.9

Graphical network of the top 20 diseases related to Caroli Disease, Isolated:



Diseases related to Caroli Disease, Isolated

Symptoms & Phenotypes for Caroli Disease, Isolated

Human phenotypes related to Caroli Disease, Isolated:

32 (show all 9)
# Description HPO Frequency HPO Source Accession
1 hepatomegaly 32 HP:0002240
2 portal hypertension 32 HP:0001409
3 vomiting 32 HP:0002013
4 esophageal varix 32 HP:0002040
5 liver abscess 32 HP:0100523
6 epigastric pain 32 HP:0410019
7 cholangitis 32 HP:0030151
8 dilatation 32 HP:0002617
9 recurrent fever 32 HP:0001954

Symptoms via clinical synopsis from OMIM:

57
G I:
hepatomegaly
portal hypertension
vomiting
liver abscess
epigastric pain
more
Misc:
polycystic kidney disease association
recurrent episodic fever

Clinical features from OMIM:

600643

Drugs & Therapeutics for Caroli Disease, Isolated

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource (Hepato/Renal Fibrocystic Diseases Core Center (UAB HFRDCC)) Recruiting NCT01401998
2 Magnetic Resonance CholangioPancreatography Signs for the Diagnosis of Caroli Disease Not yet recruiting NCT04007575

Search NIH Clinical Center for Caroli Disease, Isolated

Genetic Tests for Caroli Disease, Isolated

Anatomical Context for Caroli Disease, Isolated

MalaCards organs/tissues related to Caroli Disease, Isolated:

41
Liver, Kidney, Lung, Pancreas, Smooth Muscle

Publications for Caroli Disease, Isolated

Articles related to Caroli Disease, Isolated:

(show top 50) (show all 138)
# Title Authors PMID Year
1
Clinical and molecular characterization defines a broadened spectrum of autosomal recessive polycystic kidney disease (ARPKD). 38 8
16523049 2006
2
Evaluation of long-term results of Caroli's disease: 21 years' observation of a family with autosomal "dominant" inheritance, and review of the literature. 8
7672768 1995
3
Biliary secretion in a patient with cystic dilation of the intrahepatic biliary tree. 8
5656335 1968
4
Congenital dilation of the intrahepatic bile ducts. 8
5902263 1966
5
[Congenital polycystic dilation of the intrahepatic bile ducts; attempt at classification]. 8
13543375 1958
6
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases. 38
31165788 2019
7
Large-duct cholangiopathies: aetiology, diagnosis and treatment. 38
31288256 2019
8
Magnetic resonance imaging of fibropolycystic liver disease: the spectrum of ductal plate malformations. 38
30852632 2019
9
Liver resection and transplantation in Caroli disease and syndrome. 38
29929811 2019
10
Role of Transplant in Biliary Disease. 38
30846041 2019
11
Congenital Cystic Lesions of the Bile Ducts: Imaging-Based Diagnosis. 38
31027922 2019
12
Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern May Be Characterized by ARID1A Genetic Alterations. 38
30520820 2019
13
Caroli Disease Revisited: A Case of a Kidney Transplant Patient With Autosomal Polycystic Kidney Disease and Recurrent Episodes of Cholangitis. 38
30879585 2019
14
Evaluation of Underlying Liver Disease and Its Severity in Children Referred for Liver Transplant: a Single-Center Report From Nemazee Hospital of Shiraz. 38
30836904 2019
15
Blockade of Hedgehog Signaling Attenuates Biliary Cystogenesis in the Polycystic Kidney (PCK) Rat. 38
30036521 2018
16
Hepatic morphology abnormalities: beyond cirrhosis. 38
29043403 2018
17
β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis. 38
29140564 2018
18
[Upper abdominal pain and febrile episodes in a 44-year-old Filipino woman]. 38
28939930 2018
19
Laparoscopic hepatectomy for the treatment of Caroli's disease: a case report. 38
29520352 2018
20
Prenatal Diagnosis of Caroli Disease Associated With Autosomal Recessive Polycystic Kidney Disease by 3-D Ultrasound and Magnetic Resonance Imaging. 38
28669735 2017
21
[A case of Caroli disease in Tibet, China]. 38
29108211 2017
22
Congenital hepatic fibrosis in a 9-year-old female patient - a case report. 38
29062909 2017
23
Diffuse-Type Caroli Disease with Characteristic Central Dot Sign Complicated by Multiple Intrahepatic and Common Bile Duct Stones. 38
28633199 2017
24
Diversity of renal phenotypes in patients with WDR19 mutations: Two case reports. 38
28621010 2017
25
Canine Breed-Specific Hepatopathies. 38
28081863 2017
26
Factors associated with long-term survival after liver transplantation: A retrospective cohort study. 38
28357030 2017
27
Unusual Indications for a Liver Transplant: A Single-Center Experience. 38
28260452 2017
28
Contrast-enhanced magnetic resonance cholangiography with gadoxetic-acid-disodium for the detection of biliary-cyst communication in Caroli disease. 38
26596209 2016
29
Accessory gallbladder in an intrahepatic location mimicking a cystic tumor of the liver: A case report. 38
27858902 2016
30
Response to letter on Caroli disease. 38
27188889 2016
31
Imaging of Von Meyenburg complexes. 38
26522945 2016
32
Hepatorenal fibrocystic diseases in children. 38
26260382 2016
33
Compound heterozygous PKHD1 variants cause a wide spectrum of ductal plate malformations. 38
26385851 2015
34
Nephronophthisis 13: implications of its association with Caroli disease and altered intracellular localization of WDR19 in the kidney. 38
25726036 2015
35
Renal cystic disease and liver abnormalities: polycystic kidney and hepatic disease and the association with Caroli disease. 38
25907884 2015
36
Segmental cholangiectasia clinically worrisome for cholangiocarcinoma: comparison with recurrent pyogenic cholangitis. 38
25600951 2015
37
Fever and right upper quadrant pain in a 24-year-old male. Caroli disease and splenomegaly suggesting portal hypertension. 38
24870623 2014
38
Liver involvement in children with ciliopathies. 38
24953524 2014
39
Caroli disease associated with vein of Galen malformation in a male child. 38
24958584 2014
40
Diagnostic challenge of large congenital liver cyst in the newborn. 38
24730630 2014
41
Education and imaging. Hepatobiliary and pancreatic: focal caroli disease mimicking cholangiocarcinoma. 38
24712045 2014
42
Cutaneous disorders in liver transplant recipients. 38
24635804 2014
43
Whole exome sequencing identifies recessive PKHD1 mutations in a Chinese twin family with Caroli disease. 38
24710345 2014
44
Left-hemihepatectomy as a method of treatment of locally limited Caroli disease. 38
24413206 2013
45
Surgical management of congenital intrahepatic bile duct dilatation, Caroli's disease and syndrome: long-term results of the French Association of Surgery Multicenter Study. 38
24121258 2013
46
Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. 38
23744610 2013
47
Giant biliary cystadenoma complicated with polycystic liver: a case report. 38
24115833 2013
48
Bile duct cyst in adults: interventional treatment, resection, or transplantation? 38
23983423 2013
49
Identification of 99 novel mutations in a worldwide cohort of 1,056 patients with a nephronophthisis-related ciliopathy. 38
23559409 2013
50
Caroli disease, bilateral diffuse cystic renal dysplasia, situs inversus, postaxial polydactyly, and preauricular fistulas: a ciliopathy caused by a homozygous NPHP3 mutation. 38
21845392 2013

Variations for Caroli Disease, Isolated

Expression for Caroli Disease, Isolated

Search GEO for disease gene expression data for Caroli Disease, Isolated.

Pathways for Caroli Disease, Isolated

GO Terms for Caroli Disease, Isolated

Sources for Caroli Disease, Isolated

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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