MCID: CRT011
MIFTS: 31

Carotenemia

Categories: Gastrointestinal diseases, Metabolic diseases

Aliases & Classifications for Carotenemia

MalaCards integrated aliases for Carotenemia:

Name: Carotenemia 12 77 15
Hypercarotinemia 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9969
ICD9CM 36 278.3
NCIt 51 C26963
SNOMED-CT 69 35487009
ICD10 34 E67.1
UMLS 74 C0154271

Summaries for Carotenemia

MalaCards based summary : Carotenemia, also known as hypercarotinemia, is related to amenorrhea and pernicious anemia. An important gene associated with Carotenemia is APOA4 (Apolipoprotein A4), and among its related pathways/superpathways are Metabolism of proteins and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Affiliated tissues include skin, liver and brain, and related phenotype is Decreased free cholesterol.

Wikipedia : 77 Carotenosis is due to an excess of dietary carotenoids and results in orange discoloration of the... more...

Related Diseases for Carotenemia

Graphical network of the top 20 diseases related to Carotenemia:



Diseases related to Carotenemia

Symptoms & Phenotypes for Carotenemia

GenomeRNAi Phenotypes related to Carotenemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.62 APOA1 APOA4

Drugs & Therapeutics for Carotenemia

Search Clinical Trials , NIH Clinical Center for Carotenemia

Genetic Tests for Carotenemia

Anatomical Context for Carotenemia

MalaCards organs/tissues related to Carotenemia:

42
Skin, Liver, Brain, Testes

Publications for Carotenemia

Articles related to Carotenemia:

(show all 36)
# Title Authors Year
1
Orangechrome Due to Carotenemia Presenting as Trichrome Vitiligo. ( 29927313 )
2018
2
Carotenemia and hepatomegaly in an atopic child on an exclusion diet for a food allergy. ( 26490299 )
2017
3
Orangeness-Peeling Back the Myths Behind Carotenemia. ( 28903145 )
2017
4
Carotenemia and Age-Related Macular Degeneration: Seeing Is Believing. ( 27319957 )
2016
5
Hypercarotinemia after bariatric surgery. ( 26611152 )
2016
6
Generalized yellow discoloration of the skin. The diagnosis: carotenemia. ( 24897145 )
2014
7
A case of carotenemia associated with ingestion of nutrient supplements. ( 16556283 )
2006
8
Carotenemia in infancy and its association with prevalent feeding practices. ( 17156001 )
2006
9
Carotenemia associated with green bean ingestion. ( 15575851 )
2004
10
Carotenemia. ( 12839253 )
2003
11
Carotenoderma in metabolic carotenemia. ( 9567535 )
1997
12
Hyper-beta-carotenemia unrelated to diet: a case of brain tumor. ( 7657475 )
1995
13
Metabolic carotenemia and carotenoderma in a child. ( 7747541 )
1995
14
A correlation between carotenemia and biliary dyskinesia. ( 8340533 )
1993
15
IgA antigliadin antibodies, cellobiose/mannitol sugar test, and carotenemia in the diagnosis of and screening for celiac disease. ( 1900142 )
1991
16
Benign carotenemia in children. ( 21253272 )
1989
17
Carotenemia. ( 3318296 )
1987
18
Carotenemia. ( 3604848 )
1987
19
Dieting and carotenemia--sometimes a cause and effect. ( 6233252 )
1984
20
Amenorrhea associated with carotenemia. ( 6823046 )
1983
21
Amenorrhea associated with carotenemia. ( 6876328 )
1983
22
Carotenemia. ( 6618745 )
1983
23
Carotenemia. A review. ( 7449242 )
1981
24
Carotenemia-a caveat. ( 6108315 )
1980
25
Carotenemia vs jaundice. ( 1036531 )
1976
26
Transport of beta-carotene in serum of individuals with carotenemia. ( 4371997 )
1974
27
Carotenemia in mentally retarded children. I. Incidence and etiology. ( 4707231 )
1973
28
Carotenemia associated with papaya ingestion. ( 5696561 )
1968
29
Carotenemia. A case report. ( 6074816 )
1967
30
CAROTENEMIA AND CAROTENODERMA. ( 14115107 )
1964
31
Lycopenemia: a variant of carotenemia. ( 14437033 )
1960
32
Observations on carotenemia. ( 13509531 )
1958
33
The carotenemia of hypothyroidism. ( 13011698 )
1952
34
Carotenemia; a case report. ( 15397622 )
1949
35
Carotenemia. ( 20240682 )
1947
36
Carotenemia in a patient with pernicious anemia. ( 20240697 )
1947

Variations for Carotenemia

Expression for Carotenemia

Search GEO for disease gene expression data for Carotenemia.

Pathways for Carotenemia

Pathways related to Carotenemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 APCS APOA1 APOA4 TTR
2
Show member pathways
13.12 APCS APOA1 APOA4 TTR
3
Show member pathways
12.04 APOA1 APOA4 TTR
4 11.58 APOA1 APOA4
5
Show member pathways
11.53 APOA1 APOA4
6
Show member pathways
11.13 APOA1 APOA4 TTR
7
Show member pathways
11.01 APOA1 APOA4
8 10.97 APOA1 TTR
9 10.54 APOA1 APOA4
10 10.23 APOA1 APOA4

GO Terms for Carotenemia

Cellular components related to Carotenemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 APCS APOA1 APOA4 TTR
2 extracellular exosome GO:0070062 9.71 APCS APOA1 APOA4 TTR
3 extracellular space GO:0005615 9.67 APCS APOA1 APOA4 TTR
4 collagen-containing extracellular matrix GO:0062023 9.5 APCS APOA1 APOA4
5 early endosome GO:0005769 9.46 APOA1 APOA4
6 high-density lipoprotein particle GO:0034364 9.26 APOA1 APOA4
7 very-low-density lipoprotein particle GO:0034361 9.16 APOA1 APOA4
8 chylomicron GO:0042627 8.96 APOA1 APOA4
9 blood microparticle GO:0072562 8.8 APCS APOA1 APOA4

Biological processes related to Carotenemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.6 APOA1 APOA4
2 cholesterol homeostasis GO:0042632 9.59 APOA1 APOA4
3 cholesterol metabolic process GO:0008203 9.58 APOA1 APOA4
4 cholesterol biosynthetic process GO:0006695 9.58 APOA1 APOA4
5 triglyceride homeostasis GO:0070328 9.57 APOA1 APOA4
6 triglyceride catabolic process GO:0019433 9.56 APOA1 APOA4
7 cholesterol efflux GO:0033344 9.55 APOA1 APOA4
8 lipoprotein metabolic process GO:0042157 9.54 APOA1 APOA4
9 reverse cholesterol transport GO:0043691 9.52 APOA1 APOA4
10 high-density lipoprotein particle remodeling GO:0034375 9.51 APOA1 APOA4
11 positive regulation of lipid biosynthetic process GO:0046889 9.49 APOA1 APOA4
12 high-density lipoprotein particle assembly GO:0034380 9.48 APOA1 APOA4
13 phospholipid efflux GO:0033700 9.46 APOA1 APOA4
14 chylomicron assembly GO:0034378 9.43 APOA1 APOA4
15 positive regulation of cholesterol esterification GO:0010873 9.4 APOA1 APOA4
16 very-low-density lipoprotein particle remodeling GO:0034372 9.37 APOA1 APOA4
17 chylomicron remodeling GO:0034371 9.32 APOA1 APOA4
18 regulation of cholesterol transport GO:0032374 9.26 APOA1 APOA4
19 regulation of intestinal cholesterol absorption GO:0030300 9.16 APOA1 APOA4
20 retinoid metabolic process GO:0001523 9.13 APOA1 APOA4 TTR
21 cellular protein metabolic process GO:0044267 8.92 APCS APOA1 APOA4 TTR

Molecular functions related to Carotenemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.37 APOA1 APOA4
2 cholesterol binding GO:0015485 9.32 APOA1 APOA4
3 lipid transporter activity GO:0005319 9.26 APOA1 APOA4
4 identical protein binding GO:0042802 9.26 APCS APOA1 APOA4 TTR
5 cholesterol transporter activity GO:0017127 9.16 APOA1 APOA4
6 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 8.62 APOA1 APOA4

Sources for Carotenemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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