MCID: CRT011
MIFTS: 30

Carotenemia

Categories: Gastrointestinal diseases, Metabolic diseases

Aliases & Classifications for Carotenemia

MalaCards integrated aliases for Carotenemia:

Name: Carotenemia 12 75 15
Hypercarotinemia 12 72

Classifications:



External Ids:

Disease Ontology 12 DOID:9969
ICD9CM 35 278.3
NCIt 50 C26963
SNOMED-CT 68 35487009
ICD10 33 E67.1
UMLS 72 C0154271

Summaries for Carotenemia

MalaCards based summary : Carotenemia, also known as hypercarotinemia, is related to hypothyroidism and anorexia nervosa. An important gene associated with Carotenemia is APOA4 (Apolipoprotein A4), and among its related pathways/superpathways are Metabolism of proteins and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Affiliated tissues include skin, liver and brain, and related phenotype is Decreased free cholesterol.

Wikipedia : 75 Carotenosis is due to an excess of dietary carotenoids and results in orange discoloration of the... more...

Related Diseases for Carotenemia

Graphical network of the top 20 diseases related to Carotenemia:



Diseases related to Carotenemia

Symptoms & Phenotypes for Carotenemia

GenomeRNAi Phenotypes related to Carotenemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.62 APOA1 APOA4

Drugs & Therapeutics for Carotenemia

Search Clinical Trials , NIH Clinical Center for Carotenemia

Genetic Tests for Carotenemia

Anatomical Context for Carotenemia

MalaCards organs/tissues related to Carotenemia:

41
Skin, Liver, Brain, Testes, Thyroid

Publications for Carotenemia

Articles related to Carotenemia:

(show top 50) (show all 69)
# Title Authors PMID Year
1
Orangechrome Due to Carotenemia Presenting as Trichrome Vitiligo. 38
29927313 2018
2
Orangeness-Peeling Back the Myths Behind Carotenemia. 38
28903145 2017
3
Carotenemia and hepatomegaly in an atopic child on an exclusion diet for a food allergy. 38
26490299 2017
4
Carotenemia and Age-Related Macular Degeneration: Seeing Is Believing. 38
27319957 2016
5
Hypercarotinemia after bariatric surgery. 38
26611152 2016
6
Generalized yellow discoloration of the skin. The diagnosis: carotenemia. 38
24897145 2014
7
Systemic AL amyloidosis with unusual cutaneous presentation unmasked by carotenoderma. 38
24479650 2014
8
Yellow palms and soles: A rare skin manifestation in diabetes mellitus. 38
24251193 2013
9
X-Linked Protoporphyria 38
23409301 2013
10
Carrot man: a case of excessive beta-carotene ingestion. 38
22431270 2012
11
Diet in dermatology: revisited. 38
20228538 2010
12
Yellow skin discoloration associated with sorafenib use for treatment of metastatic renal cell carcinoma. 38
17396743 2007
13
Carotenemia in infancy and its association with prevalent feeding practices. 38
17156001 2006
14
A case of carotenemia associated with ingestion of nutrient supplements. 38
16556283 2006
15
Carotenemia associated with green bean ingestion. 38
15575851 2004
16
Carotenemia. 38
12839253 2003
17
The interrater reliability of physical signs in patients with eating disorders. 38
11767717 2001
18
Carotenoderma in metabolic carotenemia. 38
9567535 1997
19
[Hypercarotinemia is not rare in children]. 38
9446917 1997
20
[Carotenemia. Report of 11 cases]. 38
10073011 1997
21
Metabolic carotenemia and carotenoderma in a child. 38
7747541 1995
22
Hyper-beta-carotenemia unrelated to diet: a case of brain tumor. 38
7657475 1995
23
[Molecular genetic study of cystic fibrosis in the Chilean population. Relationship to its clinical expression]. 38
8191128 1993
24
A correlation between carotenemia and biliary dyskinesia. 38
8340533 1993
25
[Beta-carotene, vitamin A and carrier proteins in thyroid diseases]. 38
8475673 1993
26
[Carotenemia]. 38
1893467 1991
27
IgA antigliadin antibodies, cellobiose/mannitol sugar test, and carotenemia in the diagnosis of and screening for celiac disease. 38
1900142 1991
28
[Carotene jaundice in infants with "sugar nursing bottle syndrome"]. 38
2685580 1989
29
[The development of beta-carotenemia in dairy cows 1975-1987]. 38
2815490 1989
30
[A case report of carotenemia]. 38
2810449 1989
31
[Icterus due to carotene associated with iron deficiency anemia]. 38
2756408 1989
32
Benign carotenemia in children. 38
21253272 1989
33
Xanthoderma: case report and differential diagnosis. 38
3345684 1988
34
Carotenoids, retinoids and alpha-tocopherol in human serum: Identification and determination by reversed-phase HPLC. 38
16867416 1988
35
Carotenemia. 38
3604848 1987
36
Carotenemia. 38
3318296 1987
37
The nutritional status of subjects with anorexia nervosa. 38
3440720 1987
38
[Dietary carotenodermias]. 38
3434946 1987
39
[Clinical features of carotinemia]. 38
3887057 1985
40
Dieting and carotenemia--sometimes a cause and effect. 38
6233252 1984
41
Amenorrhea associated with carotenemia. 38
6876328 1983
42
Carotenemia. 38
6618745 1983
43
Amenorrhea associated with carotenemia. 38
6823046 1983
44
Carotenemia. A review. 38
7449242 1981
45
Carotenemia-a caveat. 38
6108315 1980
46
[Correlation of carotenemia and intestinal villosity]. 38
7209010 1980
47
Carotenemia vs jaundice. 38
1036531 1976
48
Cutaneous signs of diabetes mellitus. 38
797552 1976
49
Carotenemic, skin colour and diabetes mellitus. 38
1224904 1975
50
Transport of beta-carotene in serum of individuals with carotenemia. 38
4371997 1974

Variations for Carotenemia

Expression for Carotenemia

Search GEO for disease gene expression data for Carotenemia.

Pathways for Carotenemia

Pathways related to Carotenemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 TTR APOA4 APOA1 APCS
2
Show member pathways
13.12 TTR APOA4 APOA1 APCS
3
Show member pathways
12.04 TTR APOA4 APOA1
4 11.58 APOA4 APOA1
5
Show member pathways
11.53 APOA4 APOA1
6
Show member pathways
11.13 TTR APOA4 APOA1
7 11.01 TTR APOA1
8
Show member pathways
10.97 APOA4 APOA1
9 10.54 APOA4 APOA1
10 10.23 APOA4 APOA1

GO Terms for Carotenemia

Cellular components related to Carotenemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TTR APOA4 APOA1 APCS
2 extracellular exosome GO:0070062 9.71 TTR APOA4 APOA1 APCS
3 extracellular space GO:0005615 9.67 TTR APOA4 APOA1 APCS
4 collagen-containing extracellular matrix GO:0062023 9.5 APOA4 APOA1 APCS
5 early endosome GO:0005769 9.46 APOA4 APOA1
6 high-density lipoprotein particle GO:0034364 9.26 APOA4 APOA1
7 very-low-density lipoprotein particle GO:0034361 9.16 APOA4 APOA1
8 chylomicron GO:0042627 8.96 APOA4 APOA1
9 blood microparticle GO:0072562 8.8 APOA4 APOA1 APCS

Biological processes related to Carotenemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.6 APOA4 APOA1
2 cholesterol homeostasis GO:0042632 9.59 APOA4 APOA1
3 cholesterol metabolic process GO:0008203 9.58 APOA4 APOA1
4 cholesterol biosynthetic process GO:0006695 9.58 APOA4 APOA1
5 triglyceride homeostasis GO:0070328 9.57 APOA4 APOA1
6 triglyceride catabolic process GO:0019433 9.56 APOA4 APOA1
7 lipoprotein metabolic process GO:0042157 9.55 APOA4 APOA1
8 cholesterol efflux GO:0033344 9.54 APOA4 APOA1
9 reverse cholesterol transport GO:0043691 9.52 APOA4 APOA1
10 positive regulation of lipid biosynthetic process GO:0046889 9.51 APOA4 APOA1
11 high-density lipoprotein particle remodeling GO:0034375 9.49 APOA4 APOA1
12 high-density lipoprotein particle assembly GO:0034380 9.48 APOA4 APOA1
13 phospholipid efflux GO:0033700 9.46 APOA4 APOA1
14 chylomicron assembly GO:0034378 9.43 APOA4 APOA1
15 very-low-density lipoprotein particle remodeling GO:0034372 9.4 APOA4 APOA1
16 positive regulation of cholesterol esterification GO:0010873 9.37 APOA4 APOA1
17 chylomicron remodeling GO:0034371 9.32 APOA4 APOA1
18 regulation of cholesterol transport GO:0032374 9.26 APOA4 APOA1
19 regulation of intestinal cholesterol absorption GO:0030300 9.16 APOA4 APOA1
20 retinoid metabolic process GO:0001523 9.13 TTR APOA4 APOA1
21 cellular protein metabolic process GO:0044267 8.92 TTR APOA4 APOA1 APCS

Molecular functions related to Carotenemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.37 APOA4 APOA1
2 cholesterol binding GO:0015485 9.32 APOA4 APOA1
3 lipid transporter activity GO:0005319 9.26 APOA4 APOA1
4 identical protein binding GO:0042802 9.26 TTR APOA4 APOA1 APCS
5 cholesterol transporter activity GO:0017127 9.16 APOA4 APOA1
6 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 8.62 APOA4 APOA1

Sources for Carotenemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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