Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: CRT016
MIFTS: 52

Carotid Artery Disease

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Carotid Artery Disease

About this section

MalaCards integrated aliases for Carotid Artery Disease:

Name: Carotid Artery Disease 12 42 15 62 17
Carotid Artery Diseases 54 43 71
Disorder of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:3407
MeSH 43 D002340
NCIt 49 C84476
ICD10 32 G45.1
UMLS 71 C0007273
Sources

Summaries for Carotid Artery Disease

About this section
MedlinePlus : 42 Your carotid arteries are two large blood vessels in your neck. They supply your brain and head with blood. If you have carotid artery disease, the arteries become narrow or blocked, usually because of atherosclerosis. Atherosclerosis is the buildup of plaque, which is made up of fat, cholesterol, calcium, and other substances found in the blood. Carotid artery disease is serious because it can block the blood flow to your brain, causing a stroke. Too much plaque in the artery can cause a blockage. You can also have a blockage when a piece of plaque or a blood clot breaks off the wall of an artery. The plaque or clot can travel through the bloodstream and get stuck in one of your brain's smaller arteries. Carotid artery disease often does not cause symptoms until the blockage or narrowing is severe. One sign may be a bruit (whooshing sound) that your doctor hears when listening to your artery with a stethoscope. Another sign is a transient ischemic attack (TIA), a "mini-stroke." A TIA is like a stroke, but it only lasts a few minutes, and the symptoms usually go away within an hour. Stroke is another sign. Imaging tests can confirm whether you have carotid artery disease. Treatments may include Healthy lifestyle changes Medicines Carotid endarterectomy, surgery to remove the plaque Angioplasty, a procedure to place a balloon and stent into the artery to open it and hold it open NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Carotid Artery Disease, also known as carotid artery diseases, is related to stroke, ischemic and atherosclerosis susceptibility, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Carotid Artery Disease is SLC39A2 (Solute Carrier Family 39 Member 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. The drugs Simvastatin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are Decreased free cholesterol and cardiovascular system

PubMed Health : 62 About carotid artery disease: Carotid (ka-ROT-id) artery disease is a disease in which a waxy substance called plaque (plak) builds up inside the carotid arteries. You have two common carotid arteries, one on each side of your neck. They each divide into internal and external carotid arteries. The internal carotid arteries supply oxygen-rich blood to your brain. The external carotid arteries supply oxygen-rich blood to your face, scalp, and neck.

Sources

Related Diseases for Carotid Artery Disease

About this section

Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 361)
# Related Disease Score Top Affiliating Genes
1 stroke, ischemic 32.1 THBD REN PLG MMP9 LPA CRP
2 atherosclerosis susceptibility 31.9 THBD SELE MMP9 LPA CRP COG2
3 amaurosis fugax 31.6 MMP9 MMP8
4 carotid stenosis 31.3 SELE REN MMP9 MMP1 LPA CRP
5 retinal artery occlusion 31.3 PLG CCL2 ACE
6 hyperlipoproteinemia, type iii 31.2 LPA APOE APOB APOA1
7 central retinal artery occlusion 31.1 PLG LPA CRP
8 intracranial embolism 30.9 PLG CRP ACE
9 arteries, anomalies of 30.9 SELE REN PLG MMP9 MIR126 LPA
10 vascular disease 30.9 TIMP1 THBD SELE REN PLG MMP9
11 branch retinal artery occlusion 30.8 PLG CRP
12 hypercholesterolemia, familial, 1 30.7 LPA CRP COG2 APOE APOB APOA1
13 moyamoya disease 1 30.7 PLG MMP9 LPA
14 hypertriglyceridemia, familial 30.5 APOE APOB APOA1
15 aortic aneurysm 30.5 TIMP1 MMP9 MMP3 CRP APOE ACE
16 hypertensive retinopathy 30.5 REN CRP ACE
17 renal artery disease 30.5 REN CRP ACE
18 cerebrovascular disease 30.5 THBD SELE REN MMP9 LPA CRP
19 peripheral vascular disease 30.5 TIMP1 THBD SELE LPA CRP COG2
20 peripheral artery disease 30.4 THBD CRP CCL2 APOE APOB APOA1
21 cardiac arrest 30.4 THBD SELE REN APOE ACE
22 heart valve disease 30.4 REN MIR126 LPA CRP ACE
23 atrial fibrillation 30.4 REN MIR126 CRP ACE
24 vascular dementia 30.4 MMP9 CRP APOE ACE
25 hyperuricemia 30.4 REN CRP APOE APOB
26 homocysteinemia 30.3 THBD CRP CCL2 APOE
27 pulmonary edema 30.3 REN CRP ACE
28 antiphospholipid syndrome 30.3 THBD SELE CRP
29 microvascular complications of diabetes 1 30.3 TIMP1 MMP9 CCL2
30 coronary stenosis 30.3 CRP APOE APOB APOA1 ACE
31 sleep apnea 30.2 REN CRP CCL2 APOE APOB ACE
32 vasculitis 30.2 THBD SELE CRP CCL2
33 non-alcoholic fatty liver disease 30.1 TIMP1 MIR126 CRP APOB APOA1
34 takayasu arteritis 30.0 THBD SELE MMP9 MMP3 CRP
35 lung disease 30.0 MMP9 MMP8 CRP CCL2 ACE
36 intracranial berry aneurysm 30.0 SELE REN PLG MMP9 CRP APOE
37 end stage renal failure 29.9 THBD REN CRP COG2 APOB ACE
38 coronary artery anomaly 29.9 SELE PLG MMP9 MIR126 LPA CRP
39 generalized atherosclerosis 29.9 REN LPA CRP COG2 APOE APOB
40 lipid metabolism disorder 29.9 SELE MIR126 LPA CRP COG2 CCL2
41 intermediate coronary syndrome 29.7 REN PLG MIR126 LPA CRP COG2
42 familial hypercholesterolemia 29.7 TIMP1 MMP9 LPA CRP COG2 APOE
43 chronic kidney disease 29.6 THBD REN MMP3 LPA CRP CCL2
44 aortic aneurysm, familial abdominal, 1 29.6 TIMP1 PLG MMP9 MMP8 MMP3 MMP1
45 eye disease 29.6 PLG MMP9 MMP1 MIR126 CRP CCL2
46 coronary heart disease 1 29.5 SELE MIR126 LPA CRP COG2 APOE
47 kidney disease 29.4 THBD REN MIR126 LPA CRP COG2
48 pulmonary disease, chronic obstructive 29.4 TIMP1 MMP9 MMP8 MMP1 MIR126 CRP
49 acute myocardial infarction 29.1 THBD SELE REN PLG MMP9 MIR126
50 arteriosclerosis 28.7 TIMP1 THBD SELE MMP9 MIR126 LPA

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to Carotid Artery Disease
Sources

Symptoms & Phenotypes for Carotid Artery Disease

About this section

UMLS symptoms related to Carotid Artery Disease:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Carotid Artery Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 ACE APOA1 APOB APOE CD163 CRP
2 homeostasis/metabolism MP:0005376 10.09 ACE APOA1 APOB APOE CD163 COG2
3 hematopoietic system MP:0005397 10 ACE APOE CD163 COG2 MMP3 MMP9
4 immune system MP:0005387 9.83 ACE APOB APOE CCL2 CD163 CRP
5 liver/biliary system MP:0005370 9.23 ACE APOA1 APOB APOE PLG SELE
Sources

Drugs & Therapeutics for Carotid Artery Disease

About this section

PubMed Health treatment related to Carotid Artery Disease: 62

Treatments for carotid artery disease may include lifestyle changes, medicines, and medical procedures. The goals of treatment are to stop the disease from getting worse and to prevent a stroke . Your treatment will depend on your symptoms, how severe the disease is, and your age and overall health.

Drugs for Carotid Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 163)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
3
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
4
Metformin Approved Phase 4 657-24-9 14219 4091
5
Glyburide Approved Phase 4 10238-21-8 3488
6
Atorvastatin Approved Phase 4 134523-00-5 60823
7
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
8
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
9
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
10
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
11
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
12
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
13 Hypolipidemic Agents Phase 4
14 Anticholesteremic Agents Phase 4
15 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
16 Lipid Regulating Agents Phase 4
17 Antimetabolites Phase 4
18 Micronutrients Phase 4
19 Vitamins Phase 4
20 Trace Elements Phase 4
21 Nutrients Phase 4
22 Neurotransmitter Agents Phase 4
23 Purinergic P2Y Receptor Antagonists Phase 4
24 Rosuvastatin Calcium Phase 4 147098-20-2
25 Calcium, Dietary Phase 4
26 insulin Phase 4
27 Insulin, Globin Zinc Phase 4
28 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,... Phase 4
29 Sodium-Glucose Transporter 2 Inhibitors Phase 4
30 Vitamin B3 Phase 4
31 Vitamin B Complex Phase 4
32 Vitamin B9 Phase 4
33 Vasodilator Agents Phase 4
34 Folate Phase 4
35 Colesevelam Hydrochloride Phase 4
36 Nicotinic Acids Phase 4
37 Anti-Asthmatic Agents Phase 4
38 Respiratory System Agents Phase 4
39 Neuroprotective Agents Phase 4
40 Autonomic Agents Phase 4
41 Bronchodilator Agents Phase 4
42 Phosphodiesterase Inhibitors Phase 4
43 Phosphodiesterase 3 Inhibitors Phase 4
44 Hypoglycemic Agents Phase 4
45 Antibodies Phase 4
46 Immunologic Factors Phase 4
47 Immunoglobulins Phase 4
48 Anti-Obesity Agents Phase 4
49 Incretins Phase 4
50 Antibodies, Monoclonal Phase 4

Interventional clinical trials:

(show top 50) (show all 188)
# Name Status NCT ID Phase Drugs
1 A 2-year, Open-label, Randomized Study to Evaluate the Efficacy of Rosuvastatin Dosing Adjustment by LDL-C Level Compared to That of 5mg Maintenance Dose in Chinese Patients With Carotid Atherosclerotic Plaques Unknown status NCT02532309 Phase 4 Rosuvastatin (5mg，10mg，20mg);Rosuvastatin 5mg
2 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
3 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
4 A Carotid Stenting Boston Scientific Surveillance Program Carotid WALLSTENT Monorail Endoprosthesis FilterWire EZâ„¢ Embolic Protection System Completed NCT00741091 Phase 4
5 Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWireâ„¢ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System Completed NCT00287508 Phase 4
6 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
7 Evaluation of the Effect of Atorvastatin and Pioglitazone in Carotid Atherosclerosis With the Use of 18Fluoride-Fludeoxyglucose(FDG) Positron Emission Tomography-computed Tomography (PET-CT)Imaging Completed NCT01341730 Phase 4 Atorvastatin 20mg;Atorvastatin 20 mg + Pioglitazone 30 mg
8 Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima Media Thickness and Its Relation to Plaque Components of the Coronary Arteries in Patients With ST-Segment Elevation Acute Myocardial Infarction Completed NCT01203982 Phase 4 Rosuvastatin;Rosuvastatin
9 A Randomised Placebo-controlled Trial of Metformin on Progression of Carotid Atherosclerosis in Non-diabetic Patients With Cardiovascular Disease Treated With Conventional Risk Reducing Agents Completed NCT00723307 Phase 4 Metformin;Placebo
10 Comparative Study of Dapagliflozin Versus Glibenclamide Effect on Endothelial Function of Coronary Artery Disease Patients Completed NCT02919345 Phase 4 Dapagliflozin 10 mg;Glibenclamide 5 mg
11 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
12 Does the Magnitude of Platelet Inhibition Inversely Correlate With the Number of TCD-detected Microemboli in Asymptomatic Patients Undergoing Carotid Artery Stenting Prior to Cardiac Surgery Who Are Being Pre-treated With 300 mg or 600 mg Loading Dose of Clopidogrel? Completed NCT01146301 Phase 4 Clopidogrel
13 Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
14 Carotid Plaque Composition by Magnetic Resonance Imaging During Lipid Lowering Therapy Active, not recruiting NCT00715273 Phase 4 Atorvastatin;Niacin;Colesevelam;Placebo Niacin;Placebo Colesevelam
15 Effect of Cilostazol, a Phosphodiesterase 3 Inhibitor, on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Active, not recruiting NCT03248401 Phase 4 Cilostazol;Aspirin
16 Effect of Bydureon on Carotid Atherosclerosis Progression in T2DM Active, not recruiting NCT02162550 Phase 4 Bydureon;placebo
17 Assessment of Atherosclerotic Plaque Characteristics Change by DCE-MRI With Alirocumab - a Pilot Study Active, not recruiting NCT02992301 Phase 4 Alirocumab
18 Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy Completed NCT00231270 Phase 3
19 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
20 Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS) Completed NCT00231231 Phase 3
21 INVESTIGATION of FLOW ALTERED, SHORT TRANSCERVICAL CAROTID ARTERY STENTING in PATIENTS With SIGNIFICANT CAROTID ARTERY DISEASE With Filter. Completed NCT01685567 Phase 3
22 Prospective, Non-Randomized, Multi-Center, Single-Arm Trial to Assess Safety & Efficacy of the Acculink Carotid Stent System With the Accunet Embolic Protection System in High-Risk Patients With Carotid Artery Lesions. Completed NCT00180518 Phase 2, Phase 3
23 Atherosclerosis Monitoring and Atherogenicity Reduction Study Completed NCT01734707 Phase 3 Placebo
24 The Effects of Lutein Supplementation on Subclinical Atherosclerosis Completed NCT01534533 Phase 2, Phase 3
25 A 72-week, Prospective, Parallel-group, Partially Blinded, Controlled Phase IIIb Study Evaluating the Impact of Specific Lp(a) Apheresis on Atherosclerotic Disease Burden in Coronary Heart Disease Patients With High Lipoprotein(a) Level. Completed NCT02133807 Phase 3
26 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
27 Carotid With Bivalirudin Angioplasty Recruiting NCT00812383 Phase 2, Phase 3
28 99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques Not yet recruiting NCT03630835 Phase 2, Phase 3
29 A Prospective, Randomized, Open-Label, Pilot Study To Compare The Effect On Carotid Atherosclerosis Of A Tacrolimus-Based Regimen With Conversion From A Tacrolimus- To A Sirolimus-Based Regimen At 3-4 Months Post-Transplant In De Novo Renal Transplant Recipients Terminated NCT00311311 Phase 3 tacrolimus;mycophenolate mofetil;prednisone;sirolimus;tacrolimus;mycophenolate mofetil;prednisone
30 Abciximab Versus Aspirin for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic >50% Carotid Stenosis: A Pilot Study (ASTERICS) Terminated NCT00126139 Phase 3 Abciximab
31 Double-blinded Placebo-controlled Multicenter Study of Anti-atherosclerotic Activity of Inflaminat in Asymptomatic Participants With Subclinical Atherosclerosis Unknown status NCT01743404 Phase 2 Placebo
32 Multimodal Assessment of the Inflammatory Atheromatous Plaque : Comparison Between 68Ga-NODAGA-RGD PET/CT, 18F-FDG PET/CT, MRI AND US Unknown status NCT01608516 Phase 1, Phase 2
33 A Trial of the Safety and Efficacy of K-604 for the Treatment of Atherosclerosis Completed NCT00851500 Phase 2 K-604
34 A Multi-centre, Randomised, Double-blind, Placebo-controlled, Parallel-group Study to Investigate the Effect of the Lp-PLA2 Inhibitor SB-480848 (40, 80mg od) on Carotid Plaque Composition in Patients With Carotid Artery Disease and Planned Carotid Endarterectomy, Stratified for Statin Use and Gender, After 14+/-4 Days Treatment Completed NCT01916720 Phase 2 SB-480848 40 mg;SB-480848 80 mg;Placebo
35 A Randomized Clinical Trial to Evaluate the Effects of High Dose Statin and Niacin Therapy on Excised Plaque Biomarkers in Patients Undergoing Carotid Endarterectomy (CEA) Completed NCT00804843 Phase 2 Atorvastatin/niacin extended-release;Atorvastatin;Simvastatin;Simvastatin
36 Effect of Valsartan on Endothelial Function, Oxidative Stress, Carotid Atherosclerosis, and Endothelial Progenitor Cells (EFFERVESCENT) Completed NCT00208767 Phase 2 Valsartan;Placebo
37 Effect of High Dose Vitamin E on Carotid Atherosclerosis Completed NCT00010699 Phase 2 Vitamin E
38 Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques Not yet recruiting NCT03871725 Phase 1, Phase 2
39 Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation Not yet recruiting NCT02995642 Phase 2 18F-FPPRGD2
40 Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques Not yet recruiting NCT03382249 Phase 1, Phase 2
41 A Multi-Center, Open-Label, Dose-Finding, Feasibility Study of Optison in Contrast Enhanced U/S for the Detection of Carotid Artery Disease Terminated NCT01394926 Phase 2 Optison
42 An Exploratory, Phase II, Open Label, Single-Center, Non-Randomized Study Of [F-18] RGD-K5 Positron Emission Tomography (PET) In Participants With Carotid Artery Stenosis Terminated NCT01968226 Phase 2 [F-18] RDG-K5
43 Antioxidants and Prevention of Early Atherosclerosis Terminated NCT00000600 Phase 2 Vitamin E;Vitamin C
44 Carotid Artery Plaque Intravascular Ultrasound Evaluation Completed NCT00271076 Phase 1
45 Phase I Study to Evaluated the Safety of Noninvasive Molecular Imaging for the Detection of Inflammation in Carotid Atherosclerotic Lesions by Using Ga-68-NOTA-MSA in Healthy Volunteers and Patients With Coronary Artery Disease Completed NCT01893489 Phase 1
46 PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis Completed NCT00547976 Phase 1 [C-11]PBR28
47 Cytokine and Leukocyte Activation Profile as a Risk Factor for Cerebral Vascular Disease and Stroke Completed NCT00001368 Phase 1
48 PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With [64]Cu-25%CANF-Comb Recruiting NCT02417688 Phase 1
49 Stenting and Angioplasty With Protection in Patients At High-Risk for Endarterectomy (SAPPHIRE Worldwide) Unknown status NCT00403078
50 Assessment of MRI-based Prediction of Stroke and Other Cerebrovascular Symptoms Arising From Carotid Atherosclerotic Disease in Asymptomatic Individuals Unknown status NCT00860184

Search NIH Clinical Center for Carotid Artery Disease

Cochrane evidence based reviews: carotid artery diseases

Sources

Genetic Tests for Carotid Artery Disease

About this section
Sources

Anatomical Context for Carotid Artery Disease

About this section

MalaCards organs/tissues related to Carotid Artery Disease:

40
Heart, Brain, Testes, Lung, Endothelial, Kidney, Liver
Sources

Publications for Carotid Artery Disease

About this section

Articles related to Carotid Artery Disease:

(show top 50) (show all 2158)
# Title Authors PMID Year
1
Evaluation of 99mTC-ECD SPECT/CT brain Imaging with NeuroGam analysis in Moyamoya disease after surgical revascularization. 42
31725599 2019
2
Association between ADAMTS7 polymorphism and carotid artery plaque vulnerability. 42
31651847 2019
3
Effects of patient age on outcomes after carotid endarterectomy: A retrospective, single-center study in Korea. 42
31393403 2019
4
Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease. 54 61
18073465 2008
5
TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease. 54 61
16474172 2006
6
The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status. 54 61
15995178 2005
7
Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. 54 61
12805074 2003
8
Relationship of early carotid artery disease with lipoprotein (a), apolipoprotein B, and fibrinogen in asymptomatic essential hypertensive patients and normotensive subjects. 54 61
11730086 2001
9
Large-scale network dysfunction in vascular cognitive disorder supports connectional diaschisis in advanced arteriosclerosis. 61
31505084 2020
10
Light-induced amaurosis - a case report and brief literature review. 61
32027984 2020
11
Contrast-enhanced ultrasound perfusion patterns and serum lipid signatures of vulnerable carotid artery plaque in predicting stroke: A cohort study of carotid stenosis in Chinese patients. 61
32039838 2020
12
Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data. 61
31202755 2020
13
Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study. 61
32020031 2020
14
Arterial wall mechanical inhomogeneity detection and atherosclerotic plaque characterization using high frame rate pulse wave imaging in carotid artery disease patients in vivo. 61
31746784 2020
15
The Association Between SYNTAX Score II and Carotid Artery Disease Severity in Patients Who Underwent Coronary Artery Bypass Grafting. 61
31416325 2020
16
The potential relationship between 18F-FDG uptake and wall shear stress in a patient with carotid artery disease. 61
31970680 2020
17
Comparison of relative safety and efficacy of handmade S-shaped catheter and conventional catheters in concomitant carotid and coronary angiography. 61
31974327 2020
18
Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques. 61
31606133 2020
19
Pulmonary Artery Acceleration Time in Young Adulthood and Cardiovascular Outcomes Later in Life: The Coronary Artery Risk Development in Young Adults Study. 61
31648849 2020
20
Limb shaking transient ischemic attacks: A follow-up of 28 patients. 61
31916976 2020
21
Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis. 61
30947376 2019
22
Association between carotid 18F-NaF and 18F-FDG uptake on PET/CT with ischemic vascular brain disease on MRI in patients with carotid artery disease. 61
31571042 2019
23
A Systematic Review for the Design of In Vitro Flow Studies of the Carotid Artery Bifurcation. 61
31823191 2019
24
Perioperative Stroke in Carotid Artery Stenting as a Surrogate Marker and Predictor for 30-day Postprocedural Mortality - A Pooled Analysis of 156,000 Patients with Carotid Artery Disease. 61
31857527 2019
25
Carotid Atherosclerosis in Patients with Atrial Fibrillation. 61
31781980 2019
26
Association of Plasma Marker of Oxidized Lipid with Histologic Plaque Instability in Patients with Peripheral Artery Disease. 61
31706994 2019
27
Idiopathic Non-atherosclerotic Carotid Artery Disease. 61
31728831 2019
28
Carotid Artery Stenting in Occlusive Carotid Artery Disease: An Appraisal. 61
31857528 2019
29
The impact of post-dilatation on periprocedural outcomes during carotid artery stenting: A single-center experience. 61
31593903 2019
30
Atrial Fibrillation Prediction by Surgical Risk Scores Following Isolated Coronary Artery Bypass Grafting Surgery. 61
31659958 2019
31
Prevalence of obstructive sleep apnea in patients with peripheral arterial diseases. 61
31728764 2019
32
Correlation of Glycosylated Hemoglobin Levels with Histological and Ultrasound Characteristics of the Carotid Plaque in Diabetic and Nondiabetic Patients. 61
31344464 2019
33
Von Willebrand factor antigen levels predict major adverse cardiovascular events in patients with carotid stenosis of the ICARAS study. 61
31557676 2019
34
Paraoxonase-1 and Symptomatic Status in Carotid Artery Disease. 61
31626928 2019
35
The prevalence of polyvascular disease in patients with carotid artery disease and peripheral artery disease. 61
31456586 2019
36
[Atheromatous extra-coronary injury in patients with coronary disease: Result of a cross-sectional centre study carried out in the east of Algeria]. 61
30857643 2019
37
Frequency, risk factors, and outcomes in patients with significant carotid artery disease admitted to King Abdulaziz Medical City, Riyadh with Ischemic Stroke. 61
31872804 2019
38
Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review. 61
31272299 2019
39
Carotid artery plaque detected on ultrasound is associated with impaired cognitive state in the elderly: A population-based study in Wakiso district, Uganda. 61
31301929 2019
40
Delphi Study to Reach International Consensus Among Vascular Surgeons on Major Arterial Vascular Surgical Complications. 61
31183537 2019
41
Headache after carotid artery stenting. 61
28431833 2019
42
Concomitant ipsilateral carotid endarterectomy and stenting is an effective treatment for tandem carotid artery lesions. 61
31519511 2019
43
Concomitant severe carotid and coronary artery diseases: a separate management or concomitant approach. 61
31269295 2019
44
Management of patients with concomitant coronary and carotid artery disease. 61
31305175 2019
45
Validation of Multiparametric Ultrasonography Criteria with Digital Subtraction Angiography in Carotid Artery Disease: A Prospective Multicenter Study. 61
31238379 2019
46
Cardiac and cardiovascular morbidities in patients with psoriatic arthritis: a population-based case control study. 61
30937638 2019
47
Postoperative ischemic events in patients undergoing carotid artery stenting using algorithmic selection for embolic protection. 61
30971186 2019
48
Carotid Artery Disease and Lower Extremities Artery Disease in Patients with Chronic Obstructive Pulmonary Disease. 61
31456833 2019
49
Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. 61
31075756 2019
50
Carotid Endarterectomy and Carotid Artery Stenting in a Predominantly Symptomatic Real-World Patient Population. 61
30951917 2019
Sources

Variations for Carotid Artery Disease

About this section

Copy number variations for Carotid Artery Disease from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 49065 11 102660640 102668966 Copy number MMP1 Carotid artery disease
2 49067 11 102706527 102714342 Copy number MMP3 Carotid artery disease
3 163976 22 33196801 33259027 Copy number TIMP3 Carotid artery disease
4 207773 6 160952515 161087407 Copy number LPA Carotid artery disease
5 207774 6 160952515 161087407 Copy number LPAL2 Carotid artery disease
6 207775 6 160952515 161087407 Copy number PLG Carotid artery disease
Sources

Expression for Carotid Artery Disease

About this section
Search GEO for disease gene expression data for Carotid Artery Disease.
Sources

Pathways for Carotid Artery Disease

About this section

Pathways related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.23 TIMP1 THBD SELE PLG MMP1 APOB
2
Degradation of the extracellular matrix 65
Show member pathways
 12.67 TIMP1 PLG MMP9 MMP8 MMP3 MMP1
3
IL-17 Family Signaling Pathways 64
Show member pathways
 12.25 MMP9 MMP3 MMP1 CCL2
4
Folate Metabolism 1
Show member pathways
 12.18 PLG CRP CCL2 APOE APOB APOA1
5
Cell surface interactions at the vascular wall 65
Show member pathways
 12.15 THBD SELE MMP1 APOB
6
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.15 TIMP1 MMP3 MMP1 CCL2
7
Fluid shear stress and atherosclerosis 36
12.03 THBD SELE MMP9 CCL2
8
Statin Pathway 1
Show member pathways
 11.95 LPA APOE APOB APOA1
9
TNF signaling pathway 36
11.92 SELE MMP9 MMP3 CCL2
10
Interleukin-4 and 13 signaling 65
11.89 TIMP1 MMP9 MMP3 MMP1 CCL2
11
Binding and Uptake of Ligands by Scavenger Receptors 65
Show member pathways
 11.88 CD163 APOE APOB APOA1
12
Rheumatoid arthritis 36
11.77 MMP3 MMP1 CCL2
13
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.65 MMP9 MMP3 CD163 CCL2
14
Angiogenesis (CST) 4
11.6 TIMP1 REN MMP9 MMP3 CCL2
15
Lung fibrosis 1
11.58 TIMP1 MMP9 CCL2
16
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.58 SELE MMP9 MMP3 MMP1
17
amb2 Integrin signaling 1
11.44 PLG MMP9 LPA APOB
18
Cell adhesion_ECM remodeling 22
11.34 TIMP1 PLG MMP9 MMP3 MMP1
19
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.24 THBD MMP9 MMP1 CCL2
20
A-beta Pathways: Uptake and Degradation 64
11.13 MMP9 CCL2 APOE ACE
21
IL1 and megakaryocytes in obesity 1
11.12 TIMP1 MMP9 CCL2
22
Matrix Metalloproteinases 1
Show member pathways
 11.1 TIMP1 PLG MMP9 MMP8 MMP3 MMP1
23
A-beta Pathways: Plaque Formation and APP Metabolism 64
11.06 PLG MMP9 ACE
24
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.97 TIMP1 MMP1 CCL2
25
Cell adhesion_Cell-matrix glycoconjugates 22
10.94 SELE PLG MMP9 MMP3 MMP1
Sources

GO Terms for Carotid Artery Disease

About this section

Cellular components related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.89 PLG MMP9 MMP8 APOE APOA1
2 extracellular region GO:0005576 9.83 TIMP1 REN PLG MMP9 MMP8 MMP3
3 extracellular matrix GO:0031012 9.73 TIMP1 MMP9 MMP8 MMP3 MMP1 APOE
4 high-density lipoprotein particle GO:0034364 9.63 APOE APOB APOA1
5 very-low-density lipoprotein particle GO:0034361 9.61 APOE APOB APOA1
6 endocytic vesicle lumen GO:0071682 9.58 APOE APOB APOA1
7 low-density lipoprotein particle GO:0034362 9.54 APOE APOB APOA1
8 chylomicron GO:0042627 9.5 APOE APOB APOA1
9 extracellular space GO:0005615 9.5 TIMP1 THBD SELE REN PLG MMP9
10 discoidal high-density lipoprotein particle GO:0034365 9.48 APOE APOA1
11 intermediate-density lipoprotein particle GO:0034363 9.33 APOE APOB APOA1

Biological processes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.93 MMP9 MMP8 MMP3 MMP1
2 cytokine-mediated signaling pathway GO:0019221 9.92 TIMP1 MMP9 MMP3 MMP1 CCL2
3 leukocyte migration GO:0050900 9.89 THBD SELE MMP1 APOB
4 response to lipopolysaccharide GO:0032496 9.87 THBD SELE REN APOB
5 receptor-mediated endocytosis GO:0006898 9.86 CD163 APOE APOB APOA1
6 lipid transport GO:0006869 9.84 LPA APOE APOB APOA1
7 response to organic substance GO:0010033 9.83 TIMP1 REN APOB
8 retinoid metabolic process GO:0001523 9.77 APOE APOB APOA1
9 proteolysis GO:0006508 9.76 REN PLG MMP9 MMP8 MMP3 MMP1
10 cellular protein metabolic process GO:0044267 9.73 TIMP1 PLG MMP1 APOE APOB APOA1
11 lipoprotein metabolic process GO:0042157 9.67 APOE APOB APOA1
12 high-density lipoprotein particle assembly GO:0034380 9.65 APOE APOA1
13 phospholipid efflux GO:0033700 9.65 APOE APOA1
14 cholesterol efflux GO:0033344 9.65 APOE APOB APOA1
15 angiotensin maturation GO:0002003 9.64 REN ACE
16 high-density lipoprotein particle clearance GO:0034384 9.64 APOE APOA1
17 negative regulation of fibrinolysis GO:0051918 9.63 THBD PLG
18 low-density lipoprotein particle remodeling GO:0034374 9.63 LPA APOE APOB
19 chylomicron remnant clearance GO:0034382 9.62 APOE APOB
20 very-low-density lipoprotein particle remodeling GO:0034372 9.62 APOE APOA1
21 collagen catabolic process GO:0030574 9.62 MMP9 MMP8 MMP3 MMP1
22 positive regulation of cholesterol esterification GO:0010873 9.61 APOE APOA1
23 negative regulation of platelet activation GO:0010544 9.61 THBD APOE
24 regulation of neuroinflammatory response GO:0150077 9.61 MMP9 MMP8 MMP3
25 regulation of Cdc42 protein signal transduction GO:0032489 9.58 APOE APOA1
26 very-low-density lipoprotein particle clearance GO:0034447 9.58 APOE APOB
27 chylomicron assembly GO:0034378 9.58 APOE APOB APOA1
28 lipoprotein catabolic process GO:0042159 9.55 APOE APOB
29 chylomicron remodeling GO:0034371 9.54 APOE APOB APOA1
30 positive regulation of phospholipid efflux GO:1902995 9.51 APOE APOA1
31 lipoprotein biosynthetic process GO:0042158 9.13 APOE APOB APOA1
32 extracellular matrix disassembly GO:0022617 9.1 TIMP1 PLG MMP9 MMP8 MMP3 MMP1

Molecular functions related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 10.11 REN PLG MMP9 MMP8 MMP3 MMP1
2 zinc ion binding GO:0008270 10 TIMP1 MMP9 MMP8 MMP3 MMP1 ACE
3 signaling receptor binding GO:0005102 9.85 REN PLG CCL2 APOE APOA1
4 peptidase activity GO:0008233 9.76 REN PLG MMP9 MMP8 MMP3 MMP1
5 metalloendopeptidase activity GO:0004222 9.71 MMP9 MMP8 MMP3 MMP1
6 metallopeptidase activity GO:0008237 9.65 MMP9 MMP8 MMP3 MMP1 ACE
7 lipid transporter activity GO:0005319 9.61 APOE APOB APOA1
8 low-density lipoprotein particle receptor binding GO:0050750 9.54 CRP APOE APOB
9 intermembrane cholesterol transfer activity GO:0120020 9.5 APOE APOB APOA1
10 lipoprotein particle binding GO:0071813 9.49 APOE APOA1
11 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.48 APOE APOA1
12 serine-type endopeptidase activity GO:0004252 9.43 PLG MMP9 MMP8 MMP3 MMP1 LPA
13 endopeptidase activity GO:0004175 9.17 REN PLG MMP9 MMP8 MMP3 MMP1
Sources

Sources for Carotid Artery Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....