Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: CRT016
MIFTS: 58

Carotid Artery Disease

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Carotid Artery Disease

About this section

MalaCards integrated aliases for Carotid Artery Disease:

Name: Carotid Artery Disease 12 44 15 64 17
Carotid Artery Diseases 56 45 74
Disorder of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:3407
MeSH 45 D002340
NCIt 51 C84476
ICD10 34 G45.1
UMLS 74 C0007273
Sources

Summaries for Carotid Artery Disease

About this section
MedlinePlus : 44 Your carotid arteries are two large blood vessels in your neck. They supply your brain and head with blood. If you have carotid artery disease, the arteries become narrow or blocked, usually because of atherosclerosis. Atherosclerosis is the buildup of plaque, which is made up of fat, cholesterol, calcium, and other substances found in the blood. Carotid artery disease is serious because it can block the blood flow to your brain, causing a stroke. Too much plaque in the artery can cause a blockage. You can also have a blockage when a piece of plaque or a blood clot breaks off the wall of an artery. The plaque or clot can travel through the bloodstream and get stuck in one of your brain's smaller arteries. Carotid artery disease often does not cause symptoms until the blockage or narrowing is severe. One sign may be a bruit (whooshing sound) that your doctor hears when listening to your artery with a stethoscope. Another sign is a transient ischemic attack (TIA), a "mini-stroke." A TIA is like a stroke, but it only lasts a few minutes, and the symptoms usually go away within an hour. Stroke is another sign. Imaging tests can confirm whether you have carotid artery disease. Treatments may include Healthy lifestyle changes Medicines Carotid endarterectomy, surgery to remove the plaque Angioplasty, a procedure to place a balloon and stent into the artery to open it and hold it open NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Carotid Artery Disease, also known as carotid artery diseases, is related to atherosclerosis susceptibility and stroke, ischemic, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Carotid Artery Disease is APOB (Apolipoprotein B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. The drugs Clopidogrel and Atorvastatin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

PubMed Health : 64 About carotid artery disease: Carotid (ka-ROT-id) artery disease is a disease in which a waxy substance called plaque (plak) builds up inside the carotid arteries. You have two common carotid arteries, one on each side of your neck. They each divide into internal and external carotid arteries.The internal carotid arteries supply oxygen-rich blood to your brain. The external carotid arteries supply oxygen-rich blood to your face, scalp, and neck.

Sources

Related Diseases for Carotid Artery Disease

About this section

Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 atherosclerosis susceptibility 31.7 APOA1 APOB APOE CCL2 CRP LPA
2 stroke, ischemic 30.8 ACE APOB APOE COG2 CRP LPA
3 amaurosis fugax 30.2 MMP8 MMP9
4 vascular disease 30.2 ACE APOA1 APOB APOE CCL2 CRP
5 carotid stenosis 30.0 ACE APOE CRP MMP1 MMP9
6 microvascular complications of diabetes 1 29.8 CCL2 MMP9 TIMP1
7 chronic kidney failure 29.8 ACE APOB CRP LPA REN
8 coronary artery anomaly 29.6 ACE APOA1 APOB COG2 CRP LPA
9 sleep apnea 29.6 ACE APOE CRP REN
10 peripheral vascular disease 29.6 ACE APOA1 APOB CRP LPA SELE
11 arteries, anomalies of 29.5 ACE APOA1 APOB APOE CCL2 COG2
12 kidney disease 29.5 ACE APOE CCL2 CRP LPA REN
13 acute myocardial infarction 29.4 ACE APOA1 APOB CRP MMP9 PLG
14 heart disease 29.2 ACE APOA1 APOB APOE CRP REN
15 aortic aneurysm, familial abdominal, 1 29.0 APOE CCL2 MMP1 MMP8 MMP9 TIMP1
16 cerebrovascular disease 29.0 ACE APOA1 APOB APOE CRP MMP9
17 lipid metabolism disorder 28.9 ACE APOA1 APOB APOE COG2 CRP
18 hypercholesterolemia, familial 28.9 ACE APOA1 APOB APOE COG2 CRP
19 diabetes mellitus 28.9 ACE APOA1 APOB COG2 CRP LPA
20 myocardial infarction 27.5 ACE APOA1 APOB APOE CCL2 COG2
21 xanthoma disseminatum 10.4 APOB APOE
22 hypercholesterolemia, autosomal dominant, type b 10.4 APOB APOE
23 moderate and severe traumatic brain injury 10.4 ACE APOE
24 familial lcat deficiency 10.4 APOA1 APOE
25 defective apolipoprotein b-100 10.4 APOB APOE
26 huntington disease-like 1 10.3 APOB APOE LPA
27 lipoprotein glomerulopathy 10.3 APOB APOE LPA
28 acute anterolateral myocardial infarction 10.3 ACE PLG
29 familial cervical artery dissection 10.3
30 xanthomatosis 10.3 APOB APOE LPA
31 diabetic foot ulcers 10.3 CCL2 MMP9
32 acute transverse myelitis 10.3 APOA1 MMP9
33 amyloidosis aa 10.3 APOA1 CRP LPA
34 hyperlipoproteinemia, type v 10.3 APOA1 APOB APOE
35 chronic meningitis 10.3 CRP MMP9
36 hypertriglyceridemia, familial 10.3 APOA1 APOB APOE
37 spastic entropion 10.3 MMP1 MMP9
38 dysbaric osteonecrosis 10.3 APOA1 APOB PLG
39 autoimmune inner ear disease 10.3 MMP9 TIMP1
40 chronic actinic dermatitis 10.3 MMP1 MMP9
41 hyperalphalipoproteinemia 1 10.3 APOA1 APOB APOE
42 hepatic lipase deficiency 10.3 APOA1 APOE
43 generalized atherosclerosis 10.3 ACE APOE CRP
44 gallbladder disease 10.3 APOA1 APOB APOE
45 abetalipoproteinemia 10.3 APOA1 APOB APOE
46 pelvic inflammatory disease 10.3 CCL2 CRP MMP9
47 aortic atherosclerosis 10.3 ACE APOE LPA
48 intermediate coronary syndrome 10.3 ACE CRP PLG
49 meningitis 10.2 CCL2 CRP MMP9
50 end stage renal failure 10.2 ACE APOB CRP

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to Carotid Artery Disease
Sources

Symptoms & Phenotypes for Carotid Artery Disease

About this section

UMLS symptoms related to Carotid Artery Disease:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Carotid Artery Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ACE APOA1 APOB APOE CD163 COG2
2 cardiovascular system MP:0005385 10.23 ACE APOA1 APOB APOE CD163 CRP
3 growth/size/body region MP:0005378 10.17 ACE APOB APOE COG2 MMP9 PLG
4 immune system MP:0005387 10.17 ACE APOB APOE CCL2 CD163 CRP
5 hematopoietic system MP:0005397 10.1 ACE APOE CD163 COG2 MMP9 PLG
6 liver/biliary system MP:0005370 9.86 ACE APOA1 APOB APOE PLG SELE
7 neoplasm MP:0002006 9.63 ACE MMP1 MMP8 MMP9 PLG TIMP1
8 reproductive system MP:0005389 9.56 ACE APOB APOE MMP9 PLG REN
9 respiratory system MP:0005388 9.17 APOE CD163 MMP9 PLG SELE THBD
Sources

Drugs & Therapeutics for Carotid Artery Disease

About this section

PubMedHealth treatment related to Carotid Artery Disease: 64

Treatments for carotid artery disease may include lifestyle changes, medicines, and medical procedures. The goals of treatment are to stop the disease from getting worse and to prevent a stroke.Your treatment will depend on your symptoms, how severe the disease is, and your age and overall health.

Drugs for Carotid Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 248)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
2
Atorvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 134523-00-5 60823
3
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
4
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
5
Glyburide Approved Phase 4 10238-21-8 3488
6
Metformin Approved Phase 4,Not Applicable 657-24-9 14219 4091
7
Nicotinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 98-92-0 936
8
Simvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 79902-63-9 54454
9
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Remifentanil Approved Phase 4 132875-61-7 60815
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Angiotensin II Approved, Investigational Phase 4,Phase 2 11128-99-7, 68521-88-0, 4474-91-3 172198
14
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
15
tannic acid Approved Phase 4,Phase 3 1401-55-4
16
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
17
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
18
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
19
Evolocumab Approved Phase 4 1256937-27-5
20
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
21
Losartan Approved Phase 4 114798-26-4 3961
22
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 59-30-3 6037
24
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 59-67-6 938
25
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
26 Rosuvastatin Calcium Phase 4,Phase 3,Not Applicable 147098-20-2
27 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
28 Anticholesteremic Agents Phase 4,Phase 3,Phase 2,Not Applicable
29 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
30 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
31 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
32 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 Purinergic P2 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
34 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
36 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Trace Elements Phase 4,Phase 2,Not Applicable
38 Nutrients Phase 4,Phase 2,Not Applicable
39 Vitamins Phase 4,Phase 2,Not Applicable
40 Micronutrients Phase 4,Phase 2,Not Applicable
41 Central Nervous System Depressants Phase 4,Not Applicable
42 Protective Agents Phase 4,Phase 2,Phase 3,Not Applicable
43 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
44 Analgesics Phase 4,Phase 2,Not Applicable
45 Anesthetics Phase 4,Phase 1,Phase 2,Not Applicable
46 Anesthetics, Inhalation Phase 4,Not Applicable
47 Anesthetics, General Phase 4,Not Applicable
48 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
49 Antipyretics Phase 4,Phase 2,Not Applicable
50 Autonomic Agents Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 365)
# Name Status NCT ID Phase Drugs
1 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
2 A Study to Evaluate the Efficacy and Safety of Rosuvastatin in the Treatment of the Carotid Atherosclerotic Plaques Unknown status NCT02532309 Phase 4 Rosuvastatin (5mg，10mg，20mg);Rosuvastatin 5mg
3 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
4 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
5 A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
6 A Carotid Stenting Boston Scientific Surveillance Program Completed NCT00741091 Phase 4
7 Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study) Completed NCT00287508 Phase 4
8 Assessment of Dapagliflozin Effect on Diabetic Endothelial Dysfunction of Brachial Artery Completed NCT02919345 Phase 4 Dapagliflozin 10 mg;Glibenclamide 5 mg
9 Carotid Atherosclerosis Regression at Magnetic Resonance Assessment. Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
10 The Effect of Atorvastatin and Pioglitazone on Carotid Atherosclerosis With the Use of Positron Emission Tomography-computed Tomography (PET-CT) Completed NCT01341730 Phase 4 Atorvastatin 20mg;Atorvastatin 20 mg + Pioglitazone 30 mg
11 Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT) Completed NCT01203982 Phase 4 Rosuvastatin;Rosuvastatin
12 Carotid Atherosclerosis: MEtformin for Insulin ResistAnce Study Completed NCT00723307 Phase 4 Metformin;Placebo
13 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
14 Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
15 Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy Completed NCT02609087 Phase 4 Sevoflurane;Propofol
16 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
17 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
18 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
19 High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
20 Insulin Resistance in Patients After Carotid Revascularization Recruiting NCT03419767 Phase 4 Melatonin
21 Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication Active, not recruiting NCT00715273 Phase 4 Atorvastatin;Niacin;Colesevelam;Placebo Niacin;Placebo Colesevelam
22 Carotid Artery Stenting With Cilostazol Addition for Restenosis Active, not recruiting NCT01261234 Phase 4 Cilostazol or Non-Cilostazol
23 Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus Active, not recruiting NCT02162550 Phase 4 Bydureon;placebo
24 Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Active, not recruiting NCT03248401 Phase 4 Cilostazol;Aspirin
25 Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis (EVOCAR-1) Not yet recruiting NCT03931161 Phase 4 Evolocumab Auto-Injector [Repatha];Placebo Auto-Injector
26 Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA Terminated NCT00478673 Phase 4
27 The Effects of Dexmedetomidine and Remifentanil on Carotid Patients Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
28 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
29 Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
30 Clopidogrel Resistance and Embolism in Carotid Artery Stenting Unknown status NCT02133989 Phase 3 Ticlopidine + Ginko biloba;Clopidogrel
31 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting Unknown status NCT01331473 Phase 3
32 Safety and Efficacy Study for Reverse Flow Used During Carotid Artery Stenting Procedure Completed NCT01685567 Phase 3
33 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
34 Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) Completed NCT00231270 Phase 3
35 Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS) Completed NCT00231231 Phase 3
36 Silk Road Medical First in Man Study - Neuroprotection During Carotid Stenting and Angioplasty Completed NCT01264419 Phase 3
37 ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial" Completed NCT00180518 Phase 2, Phase 3
38 Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis Completed NCT02133807 Phase 3
39 Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
40 Atherosclerosis Monitoring and Atherogenicity Reduction Study Completed NCT01734707 Phase 3 Placebo
41 Effects of Lutein Supplementation on Subclinical Atherosclerosis Completed NCT01534533 Phase 2, Phase 3
42 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
43 IMaging Della PLAcca Carotidea Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
44 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (EMBOLDEN) Completed NCT00766493 Phase 3
45 GORE Embolic Protection With Reverse Flow Completed NCT00594100 Phase 3
46 Gadobutrol Enhanced MRA of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
47 ViVEXX Carotid Revascularization Trial (VIVA) Completed NCT00417963 Phase 3
48 Carotid Artery Stenting With Protection Registry Completed NCT00318851 Phase 3
49 SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy Completed NCT01591005 Phase 3
50 Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3

Search NIH Clinical Center for Carotid Artery Disease

Cochrane evidence based reviews: carotid artery diseases

Sources

Genetic Tests for Carotid Artery Disease

About this section
Sources

Anatomical Context for Carotid Artery Disease

About this section

MalaCards organs/tissues related to Carotid Artery Disease:

42
Heart, Brain, Testes, Lung, Kidney, Endothelial, Liver
Sources

Publications for Carotid Artery Disease

About this section

Articles related to Carotid Artery Disease:

(show top 50) (show all 725)
# Title Authors Year
1
Anti-ApoA-I IgG antibodies are not associated with carotid artery disease progression and first-time cardiovascular events in middle-aged individuals. ( 30028049 )
2019
2
Snoring and carotid artery disease: A new risk factor emerges. ( 30194704 )
2019
3
Intracerebral steal phenomenon in symptomatic carotid artery disease. ( 30389512 )
2019
4
Nonlinear model for the carotid artery disease 10-year risk prediction by fusing conventional cardiovascular factors to carotid ultrasound image phenotypes: A Japanese diabetes cohort study. ( 30623485 )
2019
5
Management of Patients with Asymptomatic and Symptomatic Carotid Artery Disease: Update on Anti-Thrombotic Therapy. ( 30703812 )
2019
6
Recent advances in the treatment of carotid artery disease. ( 30845790 )
2019
7
Carotid Artery Disease in Post-Stroke Survivors and Effects of Enriched Environment on Stroke Pathology in a Mouse Model of Carotid Artery Stenosis. ( 30947376 )
2019
8
Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia. ( 29922933 )
2018
9
The Role of Neurosonology in the Diagnosis and Management of Patients with Carotid Artery Disease: A Review. ( 29334161 )
2018
10
Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial. ( 29389037 )
2018
11
Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique? ( 29405657 )
2018
12
Renin and aldosterone are not associated with vulnerable plaque characteristics in patients with carotid artery disease. ( 29548814 )
2018
13
Regional variation in patient outcomes in carotid artery disease treatment in the Vascular Quality Initiative. ( 29571620 )
2018
14
Looking beyond luminal stenosis in carotid artery disease. ( 29622453 )
2018
15
The role of microwave radiometry in carotid artery disease. Diagnostic and clinical prospective. ( 29631128 )
2018
16
Rivaroxaban plus aspirin, compared with aspirin alone, reduced cardiovascular events in patients with stable peripheral or carotid artery disease, but increased the risk of major bleeding. ( 29650723 )
2018
17
Epicardial adipose tissue and carotid artery disease: Protocol for systematic review and meta-analysis. ( 29702973 )
2018
18
Validation of Multiparametric Ultrasonography Criteria with Digital Subtraction Angiography in Carotid Artery Disease: A Prospective Multicenter Study. ( 29797307 )
2018
19
Neovascularization in Vertebral Artery Atheroma-A Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Comparative Study in Patients with Symptomatic and Asymptomatic Carotid Artery Disease. ( 29805083 )
2018
20
Ischemic stroke/transient ischemic attack events and carotid artery disease in the absence of or with minimal coronary artery calcification: Results from the Multi-Ethnic Study of Atherosclerosis. ( 29852401 )
2018
21
Flip-Flop Phenomenon: Swallowing-Induced Arterial Displacement as an Indicator of Carotid Artery Disease. ( 29879697 )
2018
22
Reply to: "Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique?" Carotid Artery Disease and Chronic Kidney Disease-Which Came the First: The Chicken or the Egg? ( 30066383 )
2018
23
Association between Nonalcoholic Fatty Liver Disease and Carotid Artery Disease in a Community-Based Chinese Population: A Cross-Sectional Study. ( 30246712 )
2018
24
Editorial: Carotid Revasculatization vs Best Medical Management in Symptomatic Carotid Artery Disease. ( 30258256 )
2018
25
Cost-effectiveness of low-dose rivaroxaban and aspirin versus aspirin alone in people with peripheral or carotid artery disease: An Australian healthcare perspective. ( 30526023 )
2018
26
Progression of carotid artery disease could stratify a risk of coronary artery disease patients with type 2 diabetes. ( 30544223 )
2018
27
Three-Dimensional Echographic Evaluation of Carotid Artery Disease. ( 30746325 )
2018
28
Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease. ( 28776469 )
2018
29
Contemporary Management of Patients with Concomitant Coronary and Carotid Artery Disease. ( 28785837 )
2018
30
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. ( 29132880 )
2018
31
Carotid Artery Disease as a Predictor of In-Hospital Postoperative Stroke After Coronary Artery Bypass Grafting From 1999 to 2011. ( 29169797 )
2018
32
Transcarotid Transcatheter Aortic Valve Replacement as Preferred Alternative Access in a Patient With Bilateral Carotid Artery Disease. ( 29289952 )
2018
33
Higher Daily Physical Activity Level Is Associated with Lower RBC Aggregation in Carotid Artery Disease Patients at High Risk of Stroke. ( 29311973 )
2017
34
Spectral Domain Optical Coherence Tomography Findings in Carotid Artery Disease. ( 29326849 )
2017
35
Approach to concurrent coronary and carotid artery disease: Epidemiology, screening and treatment. ( 29451667 )
2017
36
Lesion Topography and Microscopic White Matter Tract Damage Contribute to Cognitive Impairment in Symptomatic Carotid Artery Disease. ( 27598537 )
2017
37
Surgical Versus Percutaneous Therapy of Carotid Artery Disease: An Evidence-Based Outcomes Analysis. ( 27712968 )
2017
38
Additional value of inflammatory biomarkers and carotid artery disease in prediction of significant coronary artery disease as assessed by coronary computed tomography angiography. ( 27742738 )
2017
39
Cerebrovascular reactivity in the caudate nucleus, lentiform nucleus and thalamus in patients with carotid artery disease. ( 27743788 )
2017
40
Endovascular prevention and treatment of stroke related to extracranial carotid artery disease. ( 27922251 )
2017
41
Biobanking in carotid artery disease: translation to clinical practice. ( 28051291 )
2017
42
Concomitant Surgical Treatment of Symptomatic Carotid Artery Disease With a Coexisting Shamblin I Carotid Body Tumor. ( 28118794 )
2017
43
Effects of Obstructive Carotid Artery Disease on Ocular Circulation and the Safety of Carotid Artery Stenting. ( 28162948 )
2017
44
Magnetic Resonance Imaging Plaque Hemorrhage for Risk Stratification in Carotid Artery Disease With Moderate Risk Under Current Medical Therapy. ( 28196937 )
2017
45
Selective-versus-Standard Poststent Dilation for Carotid Artery Disease: A Systematic Review and Meta-Analysis. ( 28302610 )
2017
46
Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative. ( 28359719 )
2017
47
Carotid artery disease and periprocedural stroke risk after transcatheter aortic valve implantation. ( 28393772 )
2017
48
Carotid Duplex Ultrasonography: Additional Imaging Is Rarely Necessary for Appropriate Treatment Planning for Carotid Artery Disease. ( 28424133 )
2017
49
Symptomatic Carotid Artery Disease: Revascularization. ( 28442330 )
2017
50
Carotid artery disease and perioperative stroke risk after surgical aortic valve replacement: A nationwide inpatient sample analysis. ( 28454636 )
2017
Sources

Variations for Carotid Artery Disease

About this section

Copy number variations for Carotid Artery Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 49065 11 102660640 102668966 Copy number MMP1 Carotid artery disease
2 49067 11 102706527 102714342 Copy number MMP3 Carotid artery disease
3 163976 22 33196801 33259027 Copy number TIMP3 Carotid artery disease
4 207773 6 160952515 161087407 Copy number LPA Carotid artery disease
5 207774 6 160952515 161087407 Copy number LPAL2 Carotid artery disease
6 207775 6 160952515 161087407 Copy number PLG Carotid artery disease
Sources

Expression for Carotid Artery Disease

About this section
Search GEO for disease gene expression data for Carotid Artery Disease.
Sources

Pathways for Carotid Artery Disease

About this section

Pathways related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 13.19 APOA1 APOB MMP1 PLG SELE THBD
2
Degradation of the extracellular matrix 67
Show member pathways
 12.64 MMP1 MMP8 MMP9 PLG TIMP1
3
Lipoprotein metabolism 67
Show member pathways
 12.46 APOA1 APOB APOE LPA
4
Cell surface interactions at the vascular wall 67
Show member pathways
 12.11 APOB MMP1 SELE THBD
5
Fluid shear stress and atherosclerosis 38
11.99 CCL2 MMP9 SELE THBD
6
Statin Pathway 1
Show member pathways
 11.91 APOA1 APOB APOE LPA
7
Interleukin-4 and 13 signaling 67
11.88 CCL2 MMP1 MMP9 TIMP1
8
TNF signaling pathway 38
11.83 CCL2 MMP9 SELE
9
Binding and Uptake of Ligands by Scavenger Receptors 67
Show member pathways
 11.83 APOA1 APOB APOE CD163
10
AGE-RAGE signaling pathway in diabetic complications 38
11.78 CCL2 SELE THBD
11
Angiogenesis (CST) 4
11.71 CCL2 MMP9 REN TIMP1
12
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.63 CCL2 CD163 MMP9
13
Lung fibrosis 1
11.56 CCL2 MMP9 TIMP1
14
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.55 MMP1 MMP9 SELE
15
Cell adhesion_ECM remodeling 23
11.49 MMP1 MMP9 PLG TIMP1
16
Selenium Micronutrient Network 1
Show member pathways
 11.43 APOA1 APOB APOE CCL2 CRP PLG
17
amb2 Integrin signaling 1
11.35 APOB LPA MMP9 PLG
18
Matrix Metalloproteinases 1
Show member pathways
 11.35 MMP1 MMP8 MMP9 PLG TIMP1
19
Cell adhesion_Cell-matrix glycoconjugates 23
11.21 MMP1 MMP9 PLG SELE
20
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.09 CCL2 MMP1 MMP9 THBD
21
IL1 and megakaryocytes in obesity 1
11.07 CCL2 MMP9 TIMP1
22
A-beta Pathways: Plaque Formation and APP Metabolism 66
11.01 ACE MMP9 PLG
23
A-beta Pathways: Uptake and Degradation 66
10.96 ACE APOE CCL2 MMP9
24
Immune response_Oncostatin M signaling via JAK-Stat in human cells 23
10.89 CCL2 MMP1 TIMP1
25
Syndecan-1-mediated signaling events 1
10.85 MMP1 MMP9
Sources

GO Terms for Carotid Artery Disease

About this section

Cellular components related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.85 APOE MMP1 MMP8 MMP9 TIMP1
2 collagen-containing extracellular matrix GO:0062023 9.83 APOA1 APOE MMP8 MMP9 PLG
3 endoplasmic reticulum lumen GO:0005788 9.8 APOA1 APOB APOE TIMP1
4 extracellular region GO:0005576 9.8 ACE APOA1 APOB APOE CCL2 CD163
5 very-low-density lipoprotein particle GO:0034361 9.58 APOA1 APOB APOE
6 endocytic vesicle lumen GO:0071682 9.54 APOA1 APOB APOE
7 low-density lipoprotein particle GO:0034362 9.5 APOA1 APOB APOE
8 discoidal high-density lipoprotein particle GO:0034365 9.48 APOA1 APOE
9 extracellular space GO:0005615 9.44 ACE APOA1 APOB APOE CCL2 CRP
10 chylomicron GO:0042627 9.43 APOA1 APOB APOE
11 intermediate-density lipoprotein particle GO:0034363 9.33 APOA1 APOB APOE

Biological processes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.99 APOA1 APOB APOE TIMP1
2 cytokine-mediated signaling pathway GO:0019221 9.96 CCL2 MMP1 MMP9 TIMP1
3 proteolysis GO:0006508 9.95 ACE LPA MMP1 MMP8 MMP9 PLG
4 receptor-mediated endocytosis GO:0006898 9.88 APOA1 APOB APOE CD163
5 leukocyte migration GO:0050900 9.88 APOB MMP1 MMP9 SELE
6 platelet degranulation GO:0002576 9.86 APOA1 PLG TIMP1
7 steroid metabolic process GO:0008202 9.86 APOA1 APOB APOE
8 response to lipopolysaccharide GO:0032496 9.84 APOB REN SELE THBD
9 response to organic substance GO:0010033 9.83 APOB REN TIMP1
10 cholesterol homeostasis GO:0042632 9.83 APOA1 APOB APOE
11 cholesterol metabolic process GO:0008203 9.82 APOA1 APOB APOE
12 lipid transport GO:0006869 9.81 APOA1 APOB APOE LPA
13 retinoid metabolic process GO:0001523 9.74 APOA1 APOB APOE
14 collagen catabolic process GO:0030574 9.7 MMP1 MMP8 MMP9
15 reverse cholesterol transport GO:0043691 9.68 APOA1 APOE
16 high-density lipoprotein particle remodeling GO:0034375 9.68 APOA1 APOE
17 positive regulation of lipid biosynthetic process GO:0046889 9.67 APOA1 APOE
18 negative regulation of blood coagulation GO:0030195 9.67 APOE THBD
19 amyloid-beta metabolic process GO:0050435 9.67 ACE REN
20 high-density lipoprotein particle assembly GO:0034380 9.65 APOA1 APOE
21 phospholipid efflux GO:0033700 9.65 APOA1 APOE
22 triglyceride catabolic process GO:0019433 9.65 APOA1 APOB APOE
23 angiotensin maturation GO:0002003 9.64 ACE REN
24 high-density lipoprotein particle clearance GO:0034384 9.63 APOA1 APOE
25 negative regulation of fibrinolysis GO:0051918 9.63 PLG THBD
26 cholesterol efflux GO:0033344 9.63 APOA1 APOB APOE
27 negative regulation of platelet activation GO:0010544 9.62 APOE THBD
28 positive regulation of cholesterol esterification GO:0010873 9.62 APOA1 APOE
29 very-low-density lipoprotein particle remodeling GO:0034372 9.61 APOA1 APOE
30 chylomicron remnant clearance GO:0034382 9.61 APOB APOE
31 lipoprotein metabolic process GO:0042157 9.61 APOA1 APOB APOE
32 regulation of Cdc42 protein signal transduction GO:0032489 9.6 APOA1 APOE
33 regulation of cholesterol transport GO:0032374 9.59 APOA1 APOE
34 very-low-density lipoprotein particle clearance GO:0034447 9.56 APOB APOE
35 regulation of neuroinflammatory response GO:0150077 9.55 MMP8 MMP9
36 low-density lipoprotein particle remodeling GO:0034374 9.54 APOB APOE LPA
37 chylomicron assembly GO:0034378 9.5 APOA1 APOB APOE
38 lipoprotein catabolic process GO:0042159 9.49 APOB APOE
39 chylomicron remodeling GO:0034371 9.43 APOA1 APOB APOE
40 cellular protein metabolic process GO:0044267 9.43 APOA1 APOB APOE MMP1 PLG TIMP1
41 lipoprotein biosynthetic process GO:0042158 9.33 APOA1 APOB APOE
42 extracellular matrix disassembly GO:0022617 9.02 MMP1 MMP8 MMP9 PLG TIMP1

Molecular functions related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.72 LPA MMP1 MMP8 MMP9 PLG
2 metallopeptidase activity GO:0008237 9.71 ACE MMP1 MMP8 MMP9
3 metalloendopeptidase activity GO:0004222 9.69 MMP1 MMP8 MMP9
4 phospholipid binding GO:0005543 9.67 APOA1 APOB APOE
5 lipid transporter activity GO:0005319 9.54 APOA1 APOB APOE
6 peptidase activity GO:0008233 9.5 ACE LPA MMP1 MMP8 MMP9 PLG
7 apolipoprotein binding GO:0034185 9.48 LPA PLG
8 lipoprotein particle binding GO:0071813 9.46 APOA1 APOE
9 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.43 APOA1 APOE
10 low-density lipoprotein particle receptor binding GO:0050750 9.43 APOB APOE CRP
11 cholesterol transporter activity GO:0017127 9.33 APOA1 APOB APOE
12 endopeptidase activity GO:0004175 9.1 ACE MMP1 MMP8 MMP9 PLG REN
13 hydrolase activity GO:0016787 10.07 ACE LPA MMP1 MMP8 MMP9 PLG
Sources

Sources for Carotid Artery Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....