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MCID: CRT016
MIFTS: 53

Carotid Artery Disease

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Carotid Artery Disease

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MalaCards integrated aliases for Carotid Artery Disease:

Name: Carotid Artery Disease 12 43 15 63 17
Carotid Artery Diseases 55 44 72
Disorder of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:3407
MeSH 44 D002340
NCIt 50 C84476
ICD10 33 G45.1
UMLS 72 C0007273
Sources

Summaries for Carotid Artery Disease

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MedlinePlus : 43 Your carotid arteries are two large blood vessels in your neck. They supply your brain and head with blood. If you have carotid artery disease, the arteries become narrow or blocked, usually because of atherosclerosis. Atherosclerosis is the buildup of plaque, which is made up of fat, cholesterol, calcium, and other substances found in the blood. Carotid artery disease is serious because it can block the blood flow to your brain, causing a stroke. Too much plaque in the artery can cause a blockage. You can also have a blockage when a piece of plaque or a blood clot breaks off the wall of an artery. The plaque or clot can travel through the bloodstream and get stuck in one of your brain's smaller arteries. Carotid artery disease often does not cause symptoms until the blockage or narrowing is severe. One sign may be a bruit (whooshing sound) that your doctor hears when listening to your artery with a stethoscope. Another sign is a transient ischemic attack (TIA), a "mini-stroke." A TIA is like a stroke, but it only lasts a few minutes, and the symptoms usually go away within an hour. Stroke is another sign. Imaging tests can confirm whether you have carotid artery disease. Treatments may include Healthy lifestyle changes Medicines Carotid endarterectomy, surgery to remove the plaque Angioplasty, a procedure to place a balloon and stent into the artery to open it and hold it open NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Carotid Artery Disease, also known as carotid artery diseases, is related to atherosclerosis susceptibility and carotid stenosis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Carotid Artery Disease is APOB (Apolipoprotein B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. The drugs Simvastatin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

PubMed Health : 63 About carotid artery disease: Carotid (ka-ROT-id) artery disease is a disease in which a waxy substance called plaque (plak) builds up inside the carotid arteries. You have two common carotid arteries, one on each side of your neck. They each divide into internal and external carotid arteries. The internal carotid arteries supply oxygen-rich blood to your brain. The external carotid arteries supply oxygen-rich blood to your face, scalp, and neck.

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Related Diseases for Carotid Artery Disease

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Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 atherosclerosis susceptibility 31.5 SELE LPA CRP CCL2 APOE APOB
2 carotid stenosis 31.3 MMP9 MMP1 CRP APOE ACE
3 amaurosis fugax 30.9 MMP9 MMP8
4 intermediate coronary syndrome 30.5 PLG CRP ACE
5 peripheral artery disease 30.5 CRP CCL2 APOB ACE
6 hypertriglyceridemia, familial 30.4 APOE APOB APOA1
7 generalized atherosclerosis 30.4 CRP APOE ACE
8 end stage renal failure 30.3 CRP APOB ACE
9 stroke, ischemic 30.1 THBD REN PLG LPA CRP COG2
10 heart valve disease 30.1 REN CRP ACE
11 hyperlipoproteinemia, type iii 30.0 LPA COG2 APOE APOB APOA1
12 hyperuricemia 30.0 REN CRP APOB
13 renal artery disease 30.0 REN ACE
14 hypertensive retinopathy 30.0 REN ACE
15 microvascular complications of diabetes 1 29.9 TIMP1 MMP9 CCL2
16 pulmonary edema 29.9 REN CRP ACE
17 sleep apnea 29.9 REN CRP APOE ACE
18 coronary stenosis 29.7 CRP APOE APOB APOA1 ACE
19 peripheral vascular disease 29.7 THBD SELE LPA CRP APOB APOA1
20 takayasu arteritis 29.7 THBD SELE MMP9 CRP
21 acute myocardial infarction 29.3 PLG MMP9 CRP APOB APOA1 ACE
22 pulmonary disease, chronic obstructive 29.3 TIMP1 MMP9 MMP1 CRP CCL2
23 coronary artery anomaly 29.2 PLG LPA CRP COG2 APOB APOA1
24 vascular disease 29.2 THBD SELE REN PLG MMP9 LPA
25 kidney disease 29.2 REN LPA CRP CCL2 APOE ACE
26 cerebrovascular disease 29.2 SELE REN MMP9 CRP APOE APOB
27 hypertension, essential 29.0 THBD REN LPA APOB APOA1 ACE
28 lipid metabolism disorder 29.0 LPA CRP COG2 APOE APOB APOA1
29 aortic aneurysm, familial abdominal, 1 28.7 TIMP1 MMP9 MMP8 MMP1 CCL2 APOE
30 coronary heart disease 1 28.5 LPA CRP COG2 APOE APOB APOA1
31 diabetes mellitus 28.3 REN LPA CRP COG2 APOB APOA1
32 arteries, anomalies of 28.1 SELE REN PLG MMP9 LPA CRP
33 diabetes mellitus, noninsulin-dependent 27.4 SELE LPA CRP COG2 CCL2 APOE
34 arteriosclerosis 27.1 SELE MMP9 LPA CRP COG2 CCL2
35 myocardial infarction 25.9 TIMP1 THBD REN PLG MMP9 LPA
36 xanthoma disseminatum 10.7 APOE APOB
37 moderate and severe traumatic brain injury 10.6 APOE ACE
38 familial lcat deficiency 10.6 APOE APOA1
39 defective apolipoprotein b-100 10.6 APOE APOB
40 transient cerebral ischemia 10.6
41 acute anterolateral myocardial infarction 10.6 PLG ACE
42 lipoprotein glomerulopathy 10.6 LPA APOE APOB
43 huntington disease-like 1 10.6 LPA APOE APOB
44 xanthomatosis 10.5 LPA APOE APOB
45 acute transverse myelitis 10.5 MMP9 APOA1
46 amyloidosis aa 10.5 LPA CRP APOA1
47 hyperlipoproteinemia, type v 10.5 APOE APOB APOA1
48 dysbaric osteonecrosis 10.5 PLG APOB APOA1
49 spastic entropion 10.5 MMP9 MMP1
50 autoimmune inner ear disease 10.5 TIMP1 MMP9

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to Carotid Artery Disease
Sources

Symptoms & Phenotypes for Carotid Artery Disease

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UMLS symptoms related to Carotid Artery Disease:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Carotid Artery Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ACE APOA1 APOB APOE CD163 COG2
2 cardiovascular system MP:0005385 10.23 ACE APOA1 APOB APOE CD163 CRP
3 growth/size/body region MP:0005378 10.17 ACE APOB APOE COG2 MMP9 PLG
4 immune system MP:0005387 10.17 ACE APOB APOE CCL2 CD163 CRP
5 hematopoietic system MP:0005397 10.1 ACE APOE CD163 COG2 MMP9 PLG
6 liver/biliary system MP:0005370 9.86 ACE APOA1 APOB APOE PLG SELE
7 neoplasm MP:0002006 9.63 ACE MMP1 MMP8 MMP9 PLG TIMP1
8 reproductive system MP:0005389 9.56 ACE APOB APOE MMP9 PLG REN
9 respiratory system MP:0005388 9.17 APOE CD163 MMP9 PLG SELE THBD
Sources

Drugs & Therapeutics for Carotid Artery Disease

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PubMed Health treatment related to Carotid Artery Disease: 63

Treatments for carotid artery disease may include lifestyle changes, medicines, and medical procedures. The goals of treatment are to stop the disease from getting worse and to prevent a stroke. Your treatment will depend on your symptoms, how severe the disease is, and your age and overall health.

Drugs for Carotid Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
3
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
4
Metformin Approved Phase 4 657-24-9 4091 14219
5
Glyburide Approved Phase 4 10238-21-8 3488
6
Atorvastatin Approved Phase 4 134523-00-5 60823
7
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
8
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
9
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
10
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
11
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
12
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
13 Lipid Regulating Agents Phase 4
14 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
15 Hypolipidemic Agents Phase 4
16 Anticholesteremic Agents Phase 4
17 Antimetabolites Phase 4
18 Micronutrients Phase 4
19 Trace Elements Phase 4
20 Vitamins Phase 4
21 Nutrients Phase 4
22 Neurotransmitter Agents Phase 4
23 Purinergic P2Y Receptor Antagonists Phase 4
24 Purinergic P2 Receptor Antagonists Phase 4
25 Rosuvastatin Calcium Phase 4 147098-20-2
26 Calcium, Dietary Phase 4
27 insulin Phase 4
28 Insulin, Globin Zinc Phase 4
29 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,... Phase 4
30 Sodium-Glucose Transporter 2 Inhibitors Phase 4
31 Colesevelam Hydrochloride Phase 4
32 Vitamin B9 Phase 4
33 Nicotinic Acids Phase 4
34 Vitamin B3 Phase 4
35 Folate Phase 4
36 Vitamin B Complex Phase 4
37 Vasodilator Agents Phase 4
38 Neuroprotective Agents Phase 4
39 Respiratory System Agents Phase 4
40 Phosphodiesterase Inhibitors Phase 4
41 Anti-Asthmatic Agents Phase 4
42 Autonomic Agents Phase 4
43 Phosphodiesterase 3 Inhibitors Phase 4
44 Bronchodilator Agents Phase 4
45 Hypoglycemic Agents Phase 4
46 Antibodies Phase 4
47 Immunologic Factors Phase 4
48 Immunoglobulins Phase 4
49 Anti-Obesity Agents Phase 4
50 Incretins Phase 4

Interventional clinical trials:

(show top 50) (show all 188)
# Name Status NCT ID Phase Drugs
1 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
2 A 2-year, Open-label, Randomized Study to Evaluate the Efficacy of Rosuvastatin Dosing Adjustment by LDL-C Level Compared to That of 5mg Maintenance Dose in Chinese Patients With Carotid Atherosclerotic Plaques Unknown status NCT02532309 Phase 4 Rosuvastatin (5mg，10mg，20mg);Rosuvastatin 5mg
3 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
4 A Carotid Stenting Boston Scientific Surveillance Program Carotid WALLSTENT Monorail Endoprosthesis FilterWire EZâ„¢ Embolic Protection System Completed NCT00741091 Phase 4
5 Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWireâ„¢ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System Completed NCT00287508 Phase 4
6 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
7 Evaluation of the Effect of Atorvastatin and Pioglitazone in Carotid Atherosclerosis With the Use of 18Fluoride-Fludeoxyglucose(FDG) Positron Emission Tomography-computed Tomography (PET-CT)Imaging Completed NCT01341730 Phase 4 Atorvastatin 20mg;Atorvastatin 20 mg + Pioglitazone 30 mg
8 Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima Media Thickness and Its Relation to Plaque Components of the Coronary Arteries in Patients With ST-Segment Elevation Acute Myocardial Infarction Completed NCT01203982 Phase 4 Rosuvastatin;Rosuvastatin
9 A Randomised Placebo-controlled Trial of Metformin on Progression of Carotid Atherosclerosis in Non-diabetic Patients With Cardiovascular Disease Treated With Conventional Risk Reducing Agents Completed NCT00723307 Phase 4 Metformin;Placebo
10 Comparative Study of Dapagliflozin Versus Glibenclamide Effect on Endothelial Function of Coronary Artery Disease Patients Completed NCT02919345 Phase 4 Dapagliflozin 10 mg;Glibenclamide 5 mg
11 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
12 Does the Magnitude of Platelet Inhibition Inversely Correlate With the Number of TCD-detected Microemboli in Asymptomatic Patients Undergoing Carotid Artery Stenting Prior to Cardiac Surgery Who Are Being Pre-treated With 300 mg or 600 mg Loading Dose of Clopidogrel? Completed NCT01146301 Phase 4 Clopidogrel
13 Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
14 Carotid Plaque Composition by Magnetic Resonance Imaging During Lipid Lowering Therapy Active, not recruiting NCT00715273 Phase 4 Atorvastatin;Niacin;Colesevelam;Placebo Niacin;Placebo Colesevelam
15 Effect of Cilostazol, a Phosphodiesterase 3 Inhibitor, on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Active, not recruiting NCT03248401 Phase 4 Cilostazol;Aspirin
16 Effect of Bydureon on Carotid Atherosclerosis Progression in T2DM Active, not recruiting NCT02162550 Phase 4 Bydureon;placebo
17 Effect of Cilostazol on In-stent Restenosis After Carotid Artery Stenting; Multi-center, Prospective, Randomized, Open-label Blind-endpoint Trial Active, not recruiting NCT01261234 Phase 4 Cilostazol or Non-Cilostazol
18 Assessment of Atherosclerotic Plaque Characteristics Change by DCE-MRI With Alirocumab - a Pilot Study Active, not recruiting NCT02992301 Phase 4 Alirocumab
19 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
20 Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy Completed NCT00231270 Phase 3
21 Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS) Completed NCT00231231 Phase 3
22 INVESTIGATION of FLOW ALTERED, SHORT TRANSCERVICAL CAROTID ARTERY STENTING in PATIENTS With SIGNIFICANT CAROTID ARTERY DISEASE With Filter. Completed NCT01685567 Phase 3
23 Prospective, Non-Randomized, Multi-Center, Single-Arm Trial to Assess Safety & Efficacy of the Acculink Carotid Stent System With the Accunet Embolic Protection System in High-Risk Patients With Carotid Artery Lesions. Completed NCT00180518 Phase 2, Phase 3
24 Atherosclerosis Monitoring and Atherogenicity Reduction Study Completed NCT01734707 Phase 3 Placebo
25 A 72-week, Prospective, Parallel-group, Partially Blinded, Controlled Phase IIIb Study Evaluating the Impact of Specific Lp(a) Apheresis on Atherosclerotic Disease Burden in Coronary Heart Disease Patients With High Lipoprotein(a) Level. Completed NCT02133807 Phase 3
26 The Effects of Lutein Supplementation on Subclinical Atherosclerosis Completed NCT01534533 Phase 2, Phase 3
27 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
28 Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
29 Carotid With Bivalirudin Angioplasty Recruiting NCT00812383 Phase 2, Phase 3
30 99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques Not yet recruiting NCT03630835 Phase 2, Phase 3
31 A Prospective, Randomized, Open-Label, Pilot Study To Compare The Effect On Carotid Atherosclerosis Of A Tacrolimus-Based Regimen With Conversion From A Tacrolimus- To A Sirolimus-Based Regimen At 3-4 Months Post-Transplant In De Novo Renal Transplant Recipients Terminated NCT00311311 Phase 3 tacrolimus;mycophenolate mofetil;prednisone;sirolimus;tacrolimus;mycophenolate mofetil;prednisone
32 Abciximab Versus Aspirin for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic >50% Carotid Stenosis: A Pilot Study (ASTERICS) Terminated NCT00126139 Phase 3 Abciximab
33 Double-blinded Placebo-controlled Multicenter Study of Anti-atherosclerotic Activity of Inflaminat in Asymptomatic Participants With Subclinical Atherosclerosis Unknown status NCT01743404 Phase 2 Placebo
34 Multimodal Assessment of the Inflammatory Atheromatous Plaque : Comparison Between 68Ga-NODAGA-RGD PET/CT, 18F-FDG PET/CT, MRI AND US Unknown status NCT01608516 Phase 1, Phase 2
35 A Trial of the Safety and Efficacy of K-604 for the Treatment of Atherosclerosis Completed NCT00851500 Phase 2 K-604
36 A Multi-centre, Randomised, Double-blind, Placebo-controlled, Parallel-group Study to Investigate the Effect of the Lp-PLA2 Inhibitor SB-480848 (40, 80mg od) on Carotid Plaque Composition in Patients With Carotid Artery Disease and Planned Carotid Endarterectomy, Stratified for Statin Use and Gender, After 14+/-4 Days Treatment Completed NCT01916720 Phase 2 SB-480848 40 mg;SB-480848 80 mg;Placebo
37 A Randomized Clinical Trial to Evaluate the Effects of High Dose Statin and Niacin Therapy on Excised Plaque Biomarkers in Patients Undergoing Carotid Endarterectomy (CEA) Completed NCT00804843 Phase 2 Atorvastatin/niacin extended-release;Atorvastatin;Simvastatin;Simvastatin
38 Effect of Valsartan on Endothelial Function, Oxidative Stress, Carotid Atherosclerosis, and Endothelial Progenitor Cells (EFFERVESCENT) Completed NCT00208767 Phase 2 Valsartan;Placebo
39 Effect of High Dose Vitamin E on Carotid Atherosclerosis Completed NCT00010699 Phase 2 Vitamin E
40 Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques Not yet recruiting NCT03871725 Phase 1, Phase 2
41 Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation Not yet recruiting NCT02995642 Phase 2 18F-FPPRGD2
42 Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques Not yet recruiting NCT03382249 Phase 1, Phase 2
43 A Multi-Center, Open-Label, Dose-Finding, Feasibility Study of Optison in Contrast Enhanced U/S for the Detection of Carotid Artery Disease Terminated NCT01394926 Phase 2 Optison
44 An Exploratory, Phase II, Open Label, Single-Center, Non-Randomized Study Of [F-18] RGD-K5 Positron Emission Tomography (PET) In Participants With Carotid Artery Stenosis Terminated NCT01968226 Phase 2 [F-18] RDG-K5
45 Antioxidants and Prevention of Early Atherosclerosis Terminated NCT00000600 Phase 2 Vitamin E;Vitamin C
46 Carotid Artery Plaque Intravascular Ultrasound Evaluation Completed NCT00271076 Phase 1
47 Phase I Study to Evaluated the Safety of Noninvasive Molecular Imaging for the Detection of Inflammation in Carotid Atherosclerotic Lesions by Using Ga-68-NOTA-MSA in Healthy Volunteers and Patients With Coronary Artery Disease Completed NCT01893489 Phase 1
48 Cytokine and Leukocyte Activation Profile as a Risk Factor for Cerebral Vascular Disease and Stroke Completed NCT00001368 Phase 1
49 PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis Completed NCT00547976 Phase 1 [C-11]PBR28
50 PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With [64]Cu-25%CANF-Comb Recruiting NCT02417688 Phase 1

Search NIH Clinical Center for Carotid Artery Disease

Cochrane evidence based reviews: carotid artery diseases

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Genetic Tests for Carotid Artery Disease

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Anatomical Context for Carotid Artery Disease

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MalaCards organs/tissues related to Carotid Artery Disease:

41
Heart, Brain, Testes, Endothelial, Lung, Kidney, Breast
Sources

Publications for Carotid Artery Disease

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Articles related to Carotid Artery Disease:

(show top 50) (show all 2127)
# Title Authors PMID Year
1
Carotid plaque magnetic resonance imaging and recurrent stroke risk: A protocol for systematic review and meta-analysis. 17
31045796 2019
2
Carotid Ultrasound. 17
30928074 2019
3
Prevalence of extracranial carotid atherosclerosis in the patients with coronary artery disease in a tertiary hospital in Malaysia. 17
30985661 2019
4
Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease. 9 38
18073465 2008
5
TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease. 9 38
16474172 2006
6
The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status. 9 38
15995178 2005
7
Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. 9 38
12805074 2003
8
Relationship of early carotid artery disease with lipoprotein (a), apolipoprotein B, and fibrinogen in asymptomatic essential hypertensive patients and normotensive subjects. 9 38
11730086 2001
9
Delphi Study to Reach International Consensus Among Vascular Surgeons on Major Arterial Vascular Surgical Complications. 38
31183537 2019
10
Validation of Multiparametric Ultrasonography Criteria with Digital Subtraction Angiography in Carotid Artery Disease: A Prospective Multicenter Study. 38
31238379 2019
11
The Association Between SYNTAX Score II and Carotid Artery Disease Severity in Patients Who Underwent Coronary Artery Bypass Grafting. 38
31416325 2019
12
Cardiac and cardiovascular morbidities in patients with psoriatic arthritis: a population-based case control study. 38
30937638 2019
13
Postoperative ischemic events in patients undergoing carotid artery stenting using algorithmic selection for embolic protection. 38
30971186 2019
14
Management of patients with concomitant coronary and carotid artery disease. 38
31305175 2019
15
Carotid artery plaque detected on ultrasound is associated with impaired cognitive state in the elderly: A population-based study in Wakiso district, Uganda. 38
31301929 2019
16
Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review. 38
31272299 2019
17
Correlation of glycosylated hemoglobin (HbA1c) levels with histological and ultrasound characteristics of the carotid plaque in diabetic and non-diabetic patients. 38
31344464 2019
18
Classification of Carotid Artery Intima Media Thickness Ultrasound Images with Deep Learning. 38
31278481 2019
19
Carotid Endarterectomy and Carotid Artery Stenting in a Predominantly Symptomatic Real-World Patient Population. 38
30951917 2019
20
Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. 38
31075756 2019
21
Concomitant severe carotid and coronary artery diseases: a separate management or concomitant approach. 38
31269295 2019
22
Recent advances in the treatment of carotid artery disease. 38
30845790 2019
23
Atrial Fibrillation: An Underestimated Cause of Ischemic Monocular Visual Loss? 38
30935808 2019
24
Opportunities for intervention: stroke treatments, disability and mortality in urban Tanzania. 38
30165650 2019
25
The risk of periodontitis for peripheral vascular disease: a systematic review and meta-analysis. 38
31345000 2019
26
Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data. 38
31202755 2019
27
[Heart-brain interactions]. 38
31066369 2019
28
Cost-effectiveness of low-dose rivaroxaban and aspirin versus aspirin alone in people with peripheral or carotid artery disease: An Australian healthcare perspective. 38
30526023 2019
29
Intracerebral steal phenomenon in symptomatic carotid artery disease. 38
30389512 2019
30
An analysis of malpractice litigation in the surgical management of carotid artery disease. 38
31125965 2019
31
Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging. 38
31205601 2019
32
High Plasma sRAGE (Soluble Receptor for Advanced Glycation End Products) Is Associated With Slower Carotid Intima-Media Thickness Progression and Lower Risk for First-Time Coronary Events and Mortality. 38
30917679 2019
33
[Management of extracranial carotid artery aneurysm]. 38
31104503 2019
34
Management of Patients with Asymptomatic and Symptomatic Carotid Artery Disease: Update on Anti-Thrombotic Therapy. 38
30703812 2019
35
Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis. 38
30947376 2019
36
Repair of descending thoracic aortic aneurysms with Ankura Thoracic Stent Graft. 38
30528410 2019
37
Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography. 38
30747592 2019
38
Circulating Microparticles in Patients with Symptomatic Carotid Disease Are Related to Embolic Plaque Activity and Recent Cerebral Ischaemia. 38
30943521 2019
39
The association of midlife cardiorespiratory fitness with later life carotid atherosclerosis: Cooper Center Longitudinal Study. 38
30731286 2019
40
[Atheromatous extra-coronary injury in patients with coronary disease: Result of a cross-sectional centre study carried out in the east of Algeria]. 38
30857643 2019
41
Effect of metformin treatment in patients with type 2 diabetes with respect to glyoxalase 1 activity in atherosclerotic lesions. 38
30421661 2019
42
Nonlinear model for the carotid artery disease 10-year risk prediction by fusing conventional cardiovascular factors to carotid ultrasound image phenotypes: A Japanese diabetes cohort study. 38
30623485 2019
43
The prognostic value of serum amyloid A for long-term mortality among patients with subclinical carotid atherosclerosis. 38
30810222 2019
44
Long-term results of carotid stenting and risk factors in patients with severe carotid artery stenosis undergoing subsequent cardiac surgery. 38
30411845 2019
45
Circulating CD14+CD16- classical monocytes do not associate with a vulnerable plaque phenotype, and do not predict secondary events in severe atherosclerotic patients. 38
30629987 2019
46
Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation. 38
29992494 2019
47
Paradoxic Relations between Basilar Artery Reconfiguration and Superior Cervical Ganglia Ischemia After Bilateral Common Carotid Artery Ligation. 38
30716499 2019
48
Is isolated hand weakness associated with subtypes of stroke? 38
30785248 2019
49
Anti-ApoA-I IgG antibodies are not associated with carotid artery disease progression and first-time cardiovascular events in middle-aged individuals. 38
30028049 2019
50
Migraine and Markers of Carotid Atherosclerosis in Middle-Aged Women: A Cross-Sectional Study. 38
30516278 2019
Sources

Variations for Carotid Artery Disease

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Copy number variations for Carotid Artery Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 49065 11 102660640 102668966 Copy number MMP1 Carotid artery disease
2 49067 11 102706527 102714342 Copy number MMP3 Carotid artery disease
3 163976 22 33196801 33259027 Copy number TIMP3 Carotid artery disease
4 207773 6 160952515 161087407 Copy number LPA Carotid artery disease
5 207774 6 160952515 161087407 Copy number LPAL2 Carotid artery disease
6 207775 6 160952515 161087407 Copy number PLG Carotid artery disease
Sources

Expression for Carotid Artery Disease

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Search GEO for disease gene expression data for Carotid Artery Disease.
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Pathways for Carotid Artery Disease

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Pathways related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 13.19 TIMP1 THBD SELE PLG MMP1 APOB
2
Degradation of the extracellular matrix 66
Show member pathways
 12.63 TIMP1 PLG MMP9 MMP8 MMP1
3
Lipoprotein metabolism 66
Show member pathways
 12.46 LPA APOE APOB APOA1
4
Cell surface interactions at the vascular wall 66
Show member pathways
 12.11 THBD SELE MMP1 APOB
5
Fluid shear stress and atherosclerosis 37
11.99 THBD SELE MMP9 CCL2
6
Statin Pathway 1
Show member pathways
 11.91 LPA APOE APOB APOA1
7
Interleukin-4 and 13 signaling 66
11.88 TIMP1 MMP9 MMP1 CCL2
8
TNF signaling pathway 37
11.84 SELE MMP9 CCL2
9
Binding and Uptake of Ligands by Scavenger Receptors 66
Show member pathways
 11.83 CD163 APOE APOB APOA1
10
AGE-RAGE signaling pathway in diabetic complications 37
11.78 THBD SELE CCL2
11
Angiogenesis (CST) 4
11.71 TIMP1 REN MMP9 CCL2
12
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.63 MMP9 CD163 CCL2
13
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.57 SELE MMP9 MMP1
14
Lung fibrosis 1
11.56 TIMP1 MMP9 CCL2
15
Cell adhesion_ECM remodeling 22
11.49 TIMP1 PLG MMP9 MMP1
16
Selenium Micronutrient Network 1
Show member pathways
 11.43 PLG CRP CCL2 APOE APOB APOA1
17
amb2 Integrin signaling 1
11.35 PLG MMP9 LPA APOB
18
Matrix Metalloproteinases 1
Show member pathways
 11.35 TIMP1 PLG MMP9 MMP8 MMP1
19
Cell adhesion_Cell-matrix glycoconjugates 22
11.21 SELE PLG MMP9 MMP1
20
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.09 THBD MMP9 MMP1 CCL2
21
IL1 and megakaryocytes in obesity 1
11.07 TIMP1 MMP9 CCL2
22
A-beta Pathways: Plaque Formation and APP Metabolism 65
11.01 PLG MMP9 ACE
23
A-beta Pathways: Uptake and Degradation 65
10.96 MMP9 CCL2 APOE ACE
24
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.89 TIMP1 MMP1 CCL2
25
Syndecan-1-mediated signaling events 1
10.85 MMP9 MMP1
Sources

GO Terms for Carotid Artery Disease

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Cellular components related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.85 TIMP1 MMP9 MMP8 MMP1 APOE
2 collagen-containing extracellular matrix GO:0062023 9.83 PLG MMP9 MMP8 APOE APOA1
3 endoplasmic reticulum lumen GO:0005788 9.8 TIMP1 APOE APOB APOA1
4 extracellular region GO:0005576 9.8 TIMP1 REN PLG MMP9 MMP8 MMP1
5 very-low-density lipoprotein particle GO:0034361 9.58 APOE APOB APOA1
6 endocytic vesicle lumen GO:0071682 9.54 APOE APOB APOA1
7 low-density lipoprotein particle GO:0034362 9.5 APOE APOB APOA1
8 discoidal high-density lipoprotein particle GO:0034365 9.48 APOE APOA1
9 extracellular space GO:0005615 9.44 TIMP1 THBD SELE REN PLG MMP9
10 chylomicron GO:0042627 9.43 APOE APOB APOA1
11 intermediate-density lipoprotein particle GO:0034363 9.33 APOE APOB APOA1

Biological processes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.99 TIMP1 APOE APOB APOA1
2 cytokine-mediated signaling pathway GO:0019221 9.96 TIMP1 MMP9 MMP1 CCL2
3 proteolysis GO:0006508 9.95 REN PLG MMP9 MMP8 MMP1 LPA
4 receptor-mediated endocytosis GO:0006898 9.88 CD163 APOE APOB APOA1
5 platelet degranulation GO:0002576 9.86 TIMP1 PLG APOA1
6 steroid metabolic process GO:0008202 9.86 APOE APOB APOA1
7 response to lipopolysaccharide GO:0032496 9.84 THBD SELE REN APOB
8 response to organic substance GO:0010033 9.83 TIMP1 REN APOB
9 cholesterol homeostasis GO:0042632 9.83 APOE APOB APOA1
10 cholesterol metabolic process GO:0008203 9.82 APOE APOB APOA1
11 lipid transport GO:0006869 9.81 LPA APOE APOB APOA1
12 leukocyte migration GO:0050900 9.75 SELE MMP1 APOB
13 retinoid metabolic process GO:0001523 9.74 APOE APOB APOA1
14 collagen catabolic process GO:0030574 9.7 MMP9 MMP8 MMP1
15 reverse cholesterol transport GO:0043691 9.68 APOE APOA1
16 positive regulation of lipid biosynthetic process GO:0046889 9.68 APOE APOA1
17 high-density lipoprotein particle remodeling GO:0034375 9.67 APOE APOA1
18 negative regulation of blood coagulation GO:0030195 9.67 THBD APOE
19 amyloid-beta metabolic process GO:0050435 9.67 REN ACE
20 high-density lipoprotein particle assembly GO:0034380 9.65 APOE APOA1
21 phospholipid efflux GO:0033700 9.65 APOE APOA1
22 triglyceride catabolic process GO:0019433 9.65 APOE APOB APOA1
23 angiotensin maturation GO:0002003 9.64 REN ACE
24 negative regulation of fibrinolysis GO:0051918 9.63 THBD PLG
25 high-density lipoprotein particle clearance GO:0034384 9.63 APOE APOA1
26 lipoprotein metabolic process GO:0042157 9.63 APOE APOB APOA1
27 very-low-density lipoprotein particle remodeling GO:0034372 9.62 APOE APOA1
28 positive regulation of cholesterol esterification GO:0010873 9.62 APOE APOA1
29 negative regulation of platelet activation GO:0010544 9.61 THBD APOE
30 chylomicron remnant clearance GO:0034382 9.61 APOE APOB
31 cholesterol efflux GO:0033344 9.61 APOE APOB APOA1
32 regulation of cholesterol transport GO:0032374 9.6 APOE APOA1
33 regulation of Cdc42 protein signal transduction GO:0032489 9.59 APOE APOA1
34 very-low-density lipoprotein particle clearance GO:0034447 9.56 APOE APOB
35 regulation of neuroinflammatory response GO:0150077 9.55 MMP9 MMP8
36 low-density lipoprotein particle remodeling GO:0034374 9.54 LPA APOE APOB
37 chylomicron assembly GO:0034378 9.5 APOE APOB APOA1
38 lipoprotein catabolic process GO:0042159 9.49 APOE APOB
39 chylomicron remodeling GO:0034371 9.43 APOE APOB APOA1
40 cellular protein metabolic process GO:0044267 9.43 TIMP1 PLG MMP1 APOE APOB APOA1
41 lipoprotein biosynthetic process GO:0042158 9.33 APOE APOB APOA1
42 extracellular matrix disassembly GO:0022617 9.02 TIMP1 PLG MMP9 MMP8 MMP1

Molecular functions related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.72 PLG MMP9 MMP8 MMP1 LPA
2 metallopeptidase activity GO:0008237 9.71 MMP9 MMP8 MMP1 ACE
3 metalloendopeptidase activity GO:0004222 9.69 MMP9 MMP8 MMP1
4 phospholipid binding GO:0005543 9.67 APOE APOB APOA1
5 lipid transporter activity GO:0005319 9.54 APOE APOB APOA1
6 peptidase activity GO:0008233 9.5 REN PLG MMP9 MMP8 MMP1 LPA
7 apolipoprotein binding GO:0034185 9.48 PLG LPA
8 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.46 APOE APOA1
9 lipoprotein particle binding GO:0071813 9.43 APOE APOA1
10 low-density lipoprotein particle receptor binding GO:0050750 9.43 CRP APOE APOB
11 cholesterol transporter activity GO:0017127 9.33 APOE APOB APOA1
12 endopeptidase activity GO:0004175 9.1 REN PLG MMP9 MMP8 MMP1 ACE
13 hydrolase activity GO:0016787 10.07 REN PLG MMP9 MMP8 MMP1 LPA
Sources

Sources for Carotid Artery Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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