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MCID: CRT016
MIFTS: 58

Carotid Artery Disease

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Carotid Artery Disease

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MalaCards integrated aliases for Carotid Artery Disease:

Name: Carotid Artery Disease 12 44 15 17 64
Carotid Artery Diseases 56 45 74
Disorder of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:3407
MeSH 45 D002340
NCIt 51 C84476
ICD10 34 G45.1
UMLS 74 C0007273
Sources

Summaries for Carotid Artery Disease

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MedlinePlus : 44 Your carotid arteries are two large blood vessels in your neck. They supply your brain and head with blood. If you have carotid artery disease, the arteries become narrow or blocked, usually because of atherosclerosis. Atherosclerosis is the buildup of plaque, which is made up of fat, cholesterol, calcium, and other substances found in the blood. Carotid artery disease is serious because it can block the blood flow to your brain, causing a stroke. Too much plaque in the artery can cause a blockage. You can also have a blockage when a piece of plaque or a blood clot breaks off the wall of an artery. The plaque or clot can travel through the bloodstream and get stuck in one of your brain's smaller arteries. Carotid artery disease often does not cause symptoms until the blockage or narrowing is severe. One sign may be a bruit (whooshing sound) that your doctor hears when listening to your artery with a stethoscope. Another sign is a transient ischemic attack (TIA), a "mini-stroke." A TIA is like a stroke, but it only lasts a few minutes, and the symptoms usually go away within an hour. Stroke is another sign. Imaging tests can confirm whether you have carotid artery disease. Treatments may include Healthy lifestyle changes Medicines Carotid endarterectomy, surgery to remove the plaque Angioplasty, a procedure to place a balloon and stent into the artery to open it and hold it open NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Carotid Artery Disease, also known as carotid artery diseases, is related to atherosclerosis susceptibility and amaurosis fugax, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Carotid Artery Disease is APOB (Apolipoprotein B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. The drugs Clopidogrel and Atorvastatin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

PubMed Health : 64 About carotid artery disease: Carotid (ka-ROT-id) artery disease is a disease in which a waxy substance called plaque (plak) builds up inside the carotid arteries. You have two common carotid arteries, one on each side of your neck. They each divide into internal and external carotid arteries.The internal carotid arteries supply oxygen-rich blood to your brain. The external carotid arteries supply oxygen-rich blood to your face, scalp, and neck.

Sources

Related Diseases for Carotid Artery Disease

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Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 atherosclerosis susceptibility 31.3 APOA1 APOB APOE CCL2 CRP LPA
2 amaurosis fugax 30.4 MMP8 MMP9
3 carotid stenosis 29.9 ACE APOE CRP MMP1 MMP9
4 vascular disease 29.9 ACE APOA1 APOB APOE CCL2 CRP
5 chronic kidney failure 29.9 ACE APOB CRP LPA REN
6 microvascular complications of diabetes 1 29.8 CCL2 MMP9 TIMP1
7 arteries, anomalies of 29.8 ACE APOA1 APOB APOE CCL2 COG2
8 coronary artery anomaly 29.7 ACE APOA1 APOB COG2 CRP LPA
9 sleep apnea 29.7 ACE APOE CRP REN
10 kidney disease 29.6 ACE APOE CCL2 CRP LPA REN
11 acute myocardial infarction 29.4 ACE APOA1 APOB CRP MMP9 PLG
12 peripheral vascular disease 29.3 ACE APOA1 APOB CRP LPA SELE
13 cerebrovascular disease 29.1 ACE APOA1 APOB APOE CRP MMP9
14 diabetes mellitus 29.1 ACE APOA1 APOB COG2 CRP LPA
15 hypercholesterolemia, familial 29.0 ACE APOA1 APOB APOE COG2 CRP
16 heart disease 28.8 ACE APOA1 APOB APOE CRP MMP3
17 aortic aneurysm, familial abdominal, 1 28.7 APOE CCL2 MMP1 MMP3 MMP8 MMP9
18 myocardial infarction 27.3 ACE APOA1 APOB APOE CCL2 COG2
19 xanthoma disseminatum 10.5 APOB APOE
20 hypercholesterolemia, autosomal dominant, type b 10.4 APOB APOE
21 moderate and severe traumatic brain injury 10.4 ACE APOE
22 familial lcat deficiency 10.4 APOA1 APOE
23 huntington disease-like 1 10.4 APOB APOE LPA
24 lipoprotein glomerulopathy 10.4 APOB APOE LPA
25 xanthomatosis 10.3 APOB APOE LPA
26 defective apolipoprotein b-100 10.3 APOB APOE
27 acute anterolateral myocardial infarction 10.3 ACE PLG
28 hyperlipoproteinemia, type v 10.3 APOA1 APOB APOE
29 amyloidosis aa 10.3 APOA1 CRP LPA
30 diabetic foot ulcers 10.3 CCL2 MMP9
31 hypertriglyceridemia, familial 10.3 APOA1 APOB APOE
32 dysbaric osteonecrosis 10.3 APOA1 APOB PLG
33 chronic actinic dermatitis 10.3 MMP1 MMP9
34 autoimmune inner ear disease 10.3 MMP9 TIMP1
35 acute transverse myelitis 10.3 APOA1 MMP9
36 familial cervical artery dissection 10.3
37 hyperalphalipoproteinemia 1 10.3 APOA1 APOB APOE
38 cytophagic histiocytic panniculitis 10.3
39 gallbladder disease 10.3 APOA1 APOB APOE
40 generalized atherosclerosis 10.3 ACE APOE CRP
41 pelvic inflammatory disease 10.3 CCL2 CRP MMP9
42 abetalipoproteinemia 10.3 APOA1 APOB APOE
43 chronic meningitis 10.3 CRP MMP9
44 aortic atherosclerosis 10.3 ACE APOE LPA
45 hepatic lipase deficiency 10.3 APOA1 APOE
46 intermediate coronary syndrome 10.3 ACE CRP PLG
47 rheumatoid nodulosis 10.3 MMP3 MMP9
48 meningitis 10.3 CCL2 CRP MMP9
49 arrhythmogenic right ventricular dysplasia, familial, 4 10.3 LPA REN
50 cerebral atherosclerosis 10.3 ACE APOA1 APOE

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to Carotid Artery Disease
Sources

Symptoms & Phenotypes for Carotid Artery Disease

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UMLS symptoms related to Carotid Artery Disease:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Carotid Artery Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACE APOA1 APOB APOE CD163 COG2
2 cardiovascular system MP:0005385 10.21 ACE APOA1 APOB APOE CD163 CRP
3 growth/size/body region MP:0005378 10.14 ACE APOB APOE COG2 MMP9 PLG
4 immune system MP:0005387 10.13 ACE APOB APOE CCL2 CD163 CRP
5 hematopoietic system MP:0005397 10.11 ACE APOE CD163 COG2 MMP3 MMP9
6 liver/biliary system MP:0005370 9.76 ACE APOA1 APOB APOE PLG SELE
7 neoplasm MP:0002006 9.43 ACE MMP1 MMP8 MMP9 PLG TIMP1
8 respiratory system MP:0005388 9.17 APOE CD163 MMP9 PLG SELE THBD
Sources

Drugs & Therapeutics for Carotid Artery Disease

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PubMedHealth treatment related to Carotid Artery Disease: 64

Treatments for carotid artery disease may include lifestyle changes, medicines, and medical procedures. The goals of treatment are to stop the disease from getting worse and to prevent a stroke.Your treatment will depend on your symptoms, how severe the disease is, and your age and overall health.

Drugs for Carotid Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 247)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
2
Atorvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 134523-00-5 60823
3
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
4
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
5
Metformin Approved Phase 4,Not Applicable 657-24-9 14219 4091
6
Glyburide Approved Phase 4 10238-21-8 3488
7
Simvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 79902-63-9 54454
8
Nicotinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 98-92-0 936
9
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Remifentanil Approved Phase 4 132875-61-7 60815
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Angiotensin II Approved, Investigational Phase 4,Phase 2 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
14
tannic acid Approved Phase 4,Phase 3 1401-55-4
15
Benzocaine Approved, Investigational Phase 4,Phase 3 94-09-7, 1994-09-7 2337
16
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
17
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
18
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
19
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
20
Losartan Approved Phase 4 114798-26-4 3961
21
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 59-30-3 6037
23
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 59-67-6 938
24
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
25 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
26 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
27 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Rosuvastatin Calcium Phase 4,Phase 3,Not Applicable 147098-20-2
29 Anticholesteremic Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
31 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
34 Purinergic P2 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Micronutrients Phase 4,Phase 2,Not Applicable
37 Nutrients Phase 4,Phase 2,Not Applicable
38 Vitamins Phase 4,Phase 2,Not Applicable
39 Trace Elements Phase 4,Phase 2,Not Applicable
40 Protective Agents Phase 4,Phase 2,Phase 3,Not Applicable
41 Central Nervous System Depressants Phase 4,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
43 Anesthetics, Inhalation Phase 4,Not Applicable
44 Anesthetics Phase 4,Phase 1,Phase 2,Not Applicable
45 Anesthetics, General Phase 4,Not Applicable
46 Analgesics Phase 4,Phase 2,Not Applicable
47 Antipyretics Phase 4,Phase 2,Not Applicable
48 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
49 Anti-Asthmatic Agents Phase 4,Not Applicable
50 Autonomic Agents Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 356)
# Name Status NCT ID Phase Drugs
1 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
2 A Study to Evaluate the Efficacy and Safety of Rosuvastatin in the Treatment of the Carotid Atherosclerotic Plaques Unknown status NCT02532309 Phase 4 Rosuvastatin (5mg，10mg，20mg);Rosuvastatin 5mg
3 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
4 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
5 A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
6 A Carotid Stenting Boston Scientific Surveillance Program Completed NCT00741091 Phase 4
7 Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study) Completed NCT00287508 Phase 4
8 Assessment of Dapagliflozin Effect on Diabetic Endothelial Dysfunction of Brachial Artery Completed NCT02919345 Phase 4 Dapagliflozin 10 mg;Glibenclamide 5 mg
9 Carotid Atherosclerosis Regression at Magnetic Resonance Assessment. Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
10 The Effect of Atorvastatin and Pioglitazone on Carotid Atherosclerosis With the Use of Positron Emission Tomography-computed Tomography (PET-CT) Completed NCT01341730 Phase 4 Atorvastatin 20mg;Atorvastatin 20 mg + Pioglitazone 30 mg
11 Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT) Completed NCT01203982 Phase 4 Rosuvastatin;Rosuvastatin
12 Carotid Atherosclerosis: MEtformin for Insulin ResistAnce Study Completed NCT00723307 Phase 4 Metformin;Placebo
13 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
14 Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
15 Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy Completed NCT02609087 Phase 4 Sevoflurane;Propofol
16 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
17 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
18 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
19 High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
20 Insulin Resistance in Patients After Carotid Revascularization Recruiting NCT03419767 Phase 4 Melatonin
21 Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication Active, not recruiting NCT00715273 Phase 4 Atorvastatin;Niacin;Colesevelam;Placebo Niacin;Placebo Colesevelam
22 Carotid Artery Stenting With Cilostazol Addition for Restenosis Active, not recruiting NCT01261234 Phase 4 Cilostazol or Non-Cilostazol
23 Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus Active, not recruiting NCT02162550 Phase 4 Bydureon;placebo
24 Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Active, not recruiting NCT03248401 Phase 4 Cilostazol;Aspirin
25 Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA Terminated NCT00478673 Phase 4
26 The Effects of Dexmedetomidine and Remifentanil on Carotid Patients Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
27 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
28 Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
29 Clopidogrel Resistance and Embolism in Carotid Artery Stenting Unknown status NCT02133989 Phase 3 Ticlopidine + Ginko biloba;Clopidogrel
30 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting Unknown status NCT01331473 Phase 3
31 Safety and Efficacy Study for Reverse Flow Used During Carotid Artery Stenting Procedure Completed NCT01685567 Phase 3
32 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
33 Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) Completed NCT00231270 Phase 3
34 Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS) Completed NCT00231231 Phase 3
35 Silk Road Medical First in Man Study - Neuroprotection During Carotid Stenting and Angioplasty Completed NCT01264419 Phase 3
36 ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial" Completed NCT00180518 Phase 2, Phase 3
37 Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis Completed NCT02133807 Phase 3
38 Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
39 Atherosclerosis Monitoring and Atherogenicity Reduction Study Completed NCT01734707 Phase 3 Placebo
40 Effects of Lutein Supplementation on Subclinical Atherosclerosis Completed NCT01534533 Phase 2, Phase 3
41 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
42 IMaging Della PLAcca Carotidea Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
43 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (EMBOLDEN) Completed NCT00766493 Phase 3
44 GORE Embolic Protection With Reverse Flow Completed NCT00594100 Phase 3
45 Gadobutrol Enhanced MRA of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
46 ViVEXX Carotid Revascularization Trial (VIVA) Completed NCT00417963 Phase 3
47 Carotid Artery Stenting With Protection Registry Completed NCT00318851 Phase 3
48 SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy Completed NCT01591005 Phase 3
49 Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3
50 Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects Completed NCT00654394 Phase 3 Rosuvastatin

Search NIH Clinical Center for Carotid Artery Disease

Cochrane evidence based reviews: carotid artery diseases

Sources

Genetic Tests for Carotid Artery Disease

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Sources

Anatomical Context for Carotid Artery Disease

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MalaCards organs/tissues related to Carotid Artery Disease:

42
Brain, Heart, Testes, Lung, Endothelial, Kidney, Whole Blood
Sources

Publications for Carotid Artery Disease

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Articles related to Carotid Artery Disease:

(show top 50) (show all 723)
# Title Authors Year
1
Progression of carotid artery disease could stratify a risk of coronary artery disease patients with type 2 diabetes. ( 30544223 )
2019
2
Nonlinear model for the carotid artery disease 10-year risk prediction by fusing conventional cardiovascular factors to carotid ultrasound image phenotypes: A Japanese diabetes cohort study. ( 30623485 )
2019
3
Management of Patients with Asymptomatic and Symptomatic Carotid Artery Disease: Update on Anti-Thrombotic Therapy. ( 30703812 )
2019
4
Recent advances in the treatment of carotid artery disease. ( 30845790 )
2019
5
Epicardial adipose tissue and carotid artery disease: Protocol for systematic review and meta-analysis. ( 29702973 )
2018
6
Validation of Multiparametric Ultrasonography Criteria with Digital Subtraction Angiography in Carotid Artery Disease: A Prospective Multicenter Study. ( 29797307 )
2018
7
The Role of Neurosonology in the Diagnosis and Management of Patients with Carotid Artery Disease: A Review. ( 29334161 )
2018
8
Ischemic stroke/transient ischemic attack events and carotid artery disease in the absence of or with minimal coronary artery calcification: Results from the Multi-Ethnic Study of Atherosclerosis. ( 29852401 )
2018
9
Flip-Flop Phenomenon: Swallowing-Induced Arterial Displacement as an Indicator of Carotid Artery Disease. ( 29879697 )
2018
10
Neovascularization in Vertebral Artery Atheroma-A Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Comparative Study in Patients with Symptomatic and Asymptomatic Carotid Artery Disease. ( 29805083 )
2018
11
Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia. ( 29922933 )
2018
12
Rivaroxaban plus aspirin, compared with aspirin alone, reduced cardiovascular events in patients with stable peripheral or carotid artery disease, but increased the risk of major bleeding. ( 29650723 )
2018
13
Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial. ( 29389037 )
2018
14
Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique? ( 29405657 )
2018
15
Regional variation in patient outcomes in carotid artery disease treatment in the Vascular Quality Initiative. ( 29571620 )
2018
16
Looking beyond luminal stenosis in carotid artery disease. ( 29622453 )
2018
17
Renin and aldosterone are not associated with vulnerable plaque characteristics in patients with carotid artery disease. ( 29548814 )
2018
18
Transcarotid Transcatheter Aortic Valve Replacement as Preferred Alternative Access in a Patient With Bilateral Carotid Artery Disease. ( 29289952 )
2018
19
The role of microwave radiometry in carotid artery disease. Diagnostic and clinical prospective. ( 29631128 )
2018
20
Anti-ApoA-I IgG antibodies are not associated with carotid artery disease progression and first-time cardiovascular events in middle-aged individuals. ( 30028049 )
2018
21
Reply to: "Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique?" Carotid Artery Disease and Chronic Kidney Disease-Which Came the First: The Chicken or the Egg? ( 30066383 )
2018
22
Snoring and carotid artery disease: A new risk factor emerges. ( 30194704 )
2018
23
Association between Nonalcoholic Fatty Liver Disease and Carotid Artery Disease in a Community-Based Chinese Population: A Cross-Sectional Study. ( 30246712 )
2018
24
Editorial: Carotid Revasculatization vs Best Medical Management in Symptomatic Carotid Artery Disease. ( 30258256 )
2018
25
Intracerebral steal phenomenon in symptomatic carotid artery disease. ( 30389512 )
2018
26
Cost-effectiveness of low-dose rivaroxaban and aspirin versus aspirin alone in people with peripheral or carotid artery disease: An Australian healthcare perspective. ( 30526023 )
2018
27
Three-Dimensional Echographic Evaluation of Carotid Artery Disease. ( 30746325 )
2018
28
Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease. ( 28776469 )
2017
29
Carotid artery disease and neurocognitive impairment. ( 28560985 )
2017
30
Endovascular prevention and treatment of stroke related to extracranial carotid artery disease. ( 27922251 )
2017
31
Chronic arsenic exposure and risk of carotid artery disease: The Strong Heart Study. ( 28554006 )
2017
32
Biobanking in carotid artery disease: translation to clinical practice. ( 28051291 )
2017
33
The association of the circle of Willis anomaly and risk of stroke in patients with carotid artery disease. ( 28746428 )
2017
34
Higher Daily Physical Activity Level Is Associated with Lower RBC Aggregation in Carotid Artery Disease Patients at High Risk of Stroke. ( 29311973 )
2017
35
Carotid Artery Disease as a Predictor of In-Hospital Postoperative Stroke After Coronary Artery Bypass Grafting From 1999 to 2011. ( 29169797 )
2017
36
Hybrid Treatment of Extracranial Carotid Artery Disease. ( 28604285 )
2017
37
Carotid artery disease and periprocedural stroke risk after transcatheter aortic valve implantation. ( 28393772 )
2017
38
Magnetic Resonance Imaging Plaque Hemorrhage for Risk Stratification in Carotid Artery Disease With Moderate Risk Under Current Medical Therapy. ( 28196937 )
2017
39
Selective-versus-Standard Poststent Dilation for Carotid Artery Disease: A Systematic Review and Meta-Analysis. ( 28302610 )
2017
40
Effects of Obstructive Carotid Artery Disease on Ocular Circulation and the Safety of Carotid Artery Stenting. ( 28162948 )
2017
41
Contemporary Management of Patients with Concomitant Coronary and Carotid Artery Disease. ( 28785837 )
2017
42
Carotid Duplex Ultrasonography: Additional Imaging Is Rarely Necessary for Appropriate Treatment Planning for Carotid Artery Disease. ( 28424133 )
2017
43
Approach to concurrent coronary and carotid artery disease: Epidemiology, screening and treatment. ( 29451667 )
2017
44
Spectral Domain Optical Coherence Tomography Findings in Carotid Artery Disease. ( 29326849 )
2017
45
Carotid artery disease and neurocognitive impairment. ( 28560984 )
2017
46
Contemporary medical therapies of atherosclerotic carotid artery disease. ( 28818261 )
2017
47
OCULAR ARTERIAL OCCLUSIVE DISORDERS AND CAROTID ARTERY DISEASE. ( 28547004 )
2017
48
Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative. ( 28359719 )
2017
49
Concomitant Surgical Treatment of Symptomatic Carotid Artery Disease With a Coexisting Shamblin I Carotid Body Tumor. ( 28118794 )
2017
50
Paraoxonase-1: Characteristics and role in atherosclerosis and carotid artery disease. ( 29189170 )
2017
Sources

Variations for Carotid Artery Disease

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Copy number variations for Carotid Artery Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 49065 11 102660640 102668966 Copy number MMP1 Carotid artery disease
2 49067 11 102706527 102714342 Copy number MMP3 Carotid artery disease
3 163976 22 33196801 33259027 Copy number TIMP3 Carotid artery disease
4 207773 6 160952515 161087407 Copy number LPA Carotid artery disease
5 207774 6 160952515 161087407 Copy number LPAL2 Carotid artery disease
6 207775 6 160952515 161087407 Copy number PLG Carotid artery disease
Sources

Expression for Carotid Artery Disease

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Search GEO for disease gene expression data for Carotid Artery Disease.
Sources

Pathways for Carotid Artery Disease

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Pathways related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 13.23 APOA1 APOB MMP1 PLG SELE THBD
2
Degradation of the extracellular matrix 67
Show member pathways
 12.65 MMP1 MMP3 MMP8 MMP9 PLG TIMP1
3
IL-17 Family Signaling Pathways 66
Show member pathways
 12.24 CCL2 MMP1 MMP3 MMP9
4
G-protein signaling Ras family GTPases in kinase cascades (scheme) 23
Show member pathways
 12.17 CCL2 MMP1 MMP3 TIMP1
5
Cell surface interactions at the vascular wall 67
Show member pathways
 12.15 APOB MMP1 SELE THBD
6
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.13 CCL2 MMP1 MMP3 MMP8 MMP9
7
Selenium Micronutrient Network 1
Show member pathways
 12.13 APOA1 APOB APOE CCL2 CRP PLG
8
Fluid shear stress and atherosclerosis 38
12.03 CCL2 MMP9 SELE THBD
9
Statin Pathway 1
Show member pathways
 11.95 APOA1 APOB APOE LPA
10
TNF signaling pathway 38
11.91 CCL2 MMP3 MMP9 SELE
11
Interleukin-4 and 13 signaling 67
11.89 CCL2 MMP1 MMP3 MMP9 TIMP1
12
Binding and Uptake of Ligands by Scavenger Receptors 67
Show member pathways
 11.88 APOA1 APOB APOE CD163
13
AGE-RAGE signaling pathway in diabetic complications 38
11.81 CCL2 SELE THBD
14
Rheumatoid arthritis 38
11.76 CCL2 MMP1 MMP3
15
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.65 CCL2 CD163 MMP3 MMP9
16
Angiogenesis (CST) 4
11.6 CCL2 MMP3 MMP9 REN TIMP1
17
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.58 MMP1 MMP3 MMP9 SELE
18
Lung fibrosis 1
11.57 CCL2 MMP9 TIMP1
19
amb2 Integrin signaling 1
11.44 APOB LPA MMP9 PLG
20
Cell adhesion_ECM remodeling 23
11.34 MMP1 MMP3 MMP9 PLG TIMP1
21
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.24 CCL2 MMP1 MMP9 THBD
22
A-beta Pathways: Uptake and Degradation 66
11.17 ACE APOE CCL2 MMP9
23
IL1 and megakaryocytes in obesity 1
11.12 CCL2 MMP9 TIMP1
24
Matrix Metalloproteinases 1
Show member pathways
 11.1 MMP1 MMP3 MMP8 MMP9 PLG TIMP1
25
A-beta Pathways: Plaque Formation and APP Metabolism 66
11.07 ACE MMP9 PLG
26
Immune response_Oncostatin M signaling via JAK-Stat in human cells 23
10.97 CCL2 MMP1 TIMP1
27
Cell adhesion_Cell-matrix glycoconjugates 23
10.94 MMP1 MMP3 MMP9 PLG SELE
28
Syndecan-1-mediated signaling events 1
10.87 MMP1 MMP9
Sources

GO Terms for Carotid Artery Disease

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Cellular components related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.85 APOA1 APOE MMP8 MMP9 PLG
2 extracellular region GO:0005576 9.83 ACE APOA1 APOB APOE CCL2 CD163
3 endoplasmic reticulum lumen GO:0005788 9.8 APOA1 APOB APOE TIMP1
4 extracellular matrix GO:0031012 9.73 APOE MMP1 MMP3 MMP8 MMP9 TIMP1
5 very-low-density lipoprotein particle GO:0034361 9.61 APOA1 APOB APOE
6 endocytic vesicle lumen GO:0071682 9.58 APOA1 APOB APOE
7 low-density lipoprotein particle GO:0034362 9.54 APOA1 APOB APOE
8 chylomicron GO:0042627 9.5 APOA1 APOB APOE
9 discoidal high-density lipoprotein particle GO:0034365 9.48 APOA1 APOE
10 extracellular space GO:0005615 9.47 ACE APOA1 APOB APOE CCL2 CRP
11 intermediate-density lipoprotein particle GO:0034363 9.33 APOA1 APOB APOE

Biological processes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.97 ACE LPA MMP1 MMP3 MMP8 MMP9
2 cytokine-mediated signaling pathway GO:0019221 9.92 CCL2 MMP1 MMP3 MMP9 TIMP1
3 receptor-mediated endocytosis GO:0006898 9.91 APOA1 APOB APOE CD163
4 leukocyte migration GO:0050900 9.88 APOB MMP1 MMP9 SELE
5 response to lipopolysaccharide GO:0032496 9.86 APOB REN SELE THBD
6 lipid transport GO:0006869 9.85 APOA1 APOB APOE LPA
7 response to organic substance GO:0010033 9.84 APOB REN TIMP1
8 cholesterol homeostasis GO:0042632 9.83 APOA1 APOB APOE
9 cholesterol metabolic process GO:0008203 9.82 APOA1 APOB APOE
10 retinoid metabolic process GO:0001523 9.75 APOA1 APOB APOE
11 triglyceride catabolic process GO:0019433 9.69 APOA1 APOB APOE
12 reverse cholesterol transport GO:0043691 9.68 APOA1 APOE
13 high-density lipoprotein particle remodeling GO:0034375 9.68 APOA1 APOE
14 positive regulation of lipid biosynthetic process GO:0046889 9.68 APOA1 APOE
15 positive regulation of protein oligomerization GO:0032461 9.67 MMP1 MMP3
16 negative regulation of blood coagulation GO:0030195 9.67 APOE THBD
17 amyloid-beta metabolic process GO:0050435 9.67 ACE REN
18 cholesterol efflux GO:0033344 9.67 APOA1 APOB APOE
19 high-density lipoprotein particle assembly GO:0034380 9.65 APOA1 APOE
20 phospholipid efflux GO:0033700 9.65 APOA1 APOE
21 lipoprotein metabolic process GO:0042157 9.65 APOA1 APOB APOE
22 angiotensin maturation GO:0002003 9.64 ACE REN
23 high-density lipoprotein particle clearance GO:0034384 9.64 APOA1 APOE
24 negative regulation of fibrinolysis GO:0051918 9.63 PLG THBD
25 negative regulation of platelet activation GO:0010544 9.63 APOE THBD
26 low-density lipoprotein particle remodeling GO:0034374 9.63 APOB APOE LPA
27 cellular protein metabolic process GO:0044267 9.63 APOA1 APOB APOE MMP1 PLG TIMP1
28 positive regulation of cholesterol esterification GO:0010873 9.62 APOA1 APOE
29 very-low-density lipoprotein particle remodeling GO:0034372 9.62 APOA1 APOE
30 collagen catabolic process GO:0030574 9.62 MMP1 MMP3 MMP8 MMP9
31 chylomicron remnant clearance GO:0034382 9.61 APOB APOE
32 chylomicron assembly GO:0034378 9.61 APOA1 APOB APOE
33 regulation of Cdc42 protein signal transduction GO:0032489 9.6 APOA1 APOE
34 regulation of cholesterol transport GO:0032374 9.59 APOA1 APOE
35 chylomicron remodeling GO:0034371 9.58 APOA1 APOB APOE
36 very-low-density lipoprotein particle clearance GO:0034447 9.57 APOB APOE
37 lipoprotein catabolic process GO:0042159 9.54 APOB APOE
38 lipoprotein biosynthetic process GO:0042158 9.43 APOA1 APOB APOE
39 regulation of neuroinflammatory response GO:0150077 9.13 MMP3 MMP8 MMP9
40 extracellular matrix disassembly GO:0022617 9.1 MMP1 MMP3 MMP8 MMP9 PLG TIMP1

Molecular functions related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.99 ACE MMP1 MMP3 MMP8 MMP9 TIMP1
2 phospholipid binding GO:0005543 9.71 APOA1 APOB APOE
3 metalloendopeptidase activity GO:0004222 9.71 MMP1 MMP3 MMP8 MMP9
4 metallopeptidase activity GO:0008237 9.65 ACE MMP1 MMP3 MMP8 MMP9
5 serine-type endopeptidase activity GO:0004252 9.63 LPA MMP1 MMP3 MMP8 MMP9 PLG
6 lipid transporter activity GO:0005319 9.61 APOA1 APOB APOE
7 peptidase activity GO:0008233 9.56 ACE LPA MMP1 MMP3 MMP8 MMP9
8 low-density lipoprotein particle receptor binding GO:0050750 9.54 APOB APOE CRP
9 apolipoprotein binding GO:0034185 9.52 LPA PLG
10 cholesterol transporter activity GO:0017127 9.5 APOA1 APOB APOE
11 lipoprotein particle binding GO:0071813 9.48 APOA1 APOE
12 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.46 APOA1 APOE
13 endopeptidase activity GO:0004175 9.17 ACE MMP1 MMP3 MMP8 MMP9 PLG
14 hydrolase activity GO:0016787 10.1 ACE LPA MMP1 MMP3 MMP8 MMP9
Sources

Sources for Carotid Artery Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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