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MCID: CRT016
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Carotid Artery Disease

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases
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Aliases & Classifications for Carotid Artery Disease

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MalaCards integrated aliases for Carotid Artery Disease:

Name: Carotid Artery Disease 11 41 14 63 16
Carotid Artery Diseases 53 43 71
Disorder of Carotid Artery 11

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:3407
MeSH 43 D002340
NCIt 49 C84476
SNOMED-CT 68 371160000
ICD10 31 G45.1
UMLS 71 C0007273
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Summaries for Carotid Artery Disease

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MedlinePlus: 41 Your carotid arteries are two large blood vessels in your neck. They supply your brain and head with blood. If you have carotid artery disease, the arteries become narrow or blocked, usually because of atherosclerosis. Atherosclerosis is the buildup of plaque, which is made up of fat, cholesterol, calcium, and other substances found in the blood. Carotid artery disease is serious because it can block the blood flow to your brain, causing a stroke. Too much plaque in the artery can cause a blockage. You can also have a blockage when a piece of plaque or a blood clot breaks off the wall of an artery. The plaque or clot can travel through the bloodstream and get stuck in one of your brain's smaller arteries. Carotid artery disease often does not cause symptoms until the blockage or narrowing is severe. One sign may be a bruit (whooshing sound) that your doctor hears when listening to your artery with a stethoscope. Another sign is a transient ischemic attack (TIA), a "mini-stroke." A TIA is like a stroke, but it only lasts a few minutes, and the symptoms usually go away within an hour. Stroke is another sign. Imaging tests can confirm whether you have carotid artery disease. Treatments may include: Healthy lifestyle changes Medicines Carotid endarterectomy, surgery to remove the plaque Angioplasty, a procedure to place a balloon and stent into the artery to open it and hold it open NIH: National Heart, Lung, and Blood Institute

MalaCards based summary: Carotid Artery Disease, also known as carotid artery diseases, is related to arteries, anomalies of and carotid stenosis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Carotid Artery Disease is SLC39A2 (Solute Carrier Family 39 Member 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Defects of contact activation system (CAS) and kallikrein/kinin system (KKS). The drugs Exenatide and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related phenotypes are Increased free cholesterol and homeostasis/metabolism

PubMed Health : 63 Carotid artery disease: Carotid (ka-ROT-id) artery disease is a disease in which a waxy substance called plaque (plak) builds up inside the carotid arteries. You have two common carotid arteries, one on each side of your neck. They each divide into internal and external carotid arteries. The internal carotid arteries supply oxygen-rich blood to your brain. The external carotid arteries supply oxygen-rich blood to your face, scalp, and neck.
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Related Diseases for Carotid Artery Disease

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Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 476)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 31.9 PLG MIR199A1 MIR126 IL6 CRP APOE
2 carotid stenosis 31.7 VWF SELP MIR330 LPA CRP APOE
3 atherosclerosis susceptibility 31.2 VWF SELP PON1 PLAT LPA IL6
4 vascular disease 31.1 VWF SELP PON1 PLAT MIR199A1 MIR126
5 hyperlipoproteinemia, type iii 31.1 LPA APOE APOB
6 stroke, ischemic 31.0 VWF SELP PON1 PLG PLAT P2RY12
7 carotid artery occlusion 31.0 SELP PLG PLAT
8 retinal artery occlusion 30.9 PLG IL6 CRP ACE
9 transient cerebral ischemia 30.9 VWF PLG PLAT P2RY12 IL6 F3
10 hypolipoproteinemia 30.9 LPA APOE APOB APOA2
11 hypercholesterolemia, familial, 1 30.8 LPA CRP APOE APOB APOA2 ACE
12 branch retinal artery occlusion 30.8 PLG F3 CRP
13 central retinal artery occlusion 30.8 PLG PLAT F3 CRP
14 hypoalphalipoproteinemia, primary, 2 30.7 PON1 LPA APOB APOA2
15 endocarditis 30.6 PLAT IL6 CRP
16 rubeosis iridis 30.6 PLG IL6
17 aortic aneurysm 30.5 MIR126 IL6 F3 CRP APOE ACE
18 hemiplegia 30.5 PLG PLAT CRP
19 microvascular complications of diabetes 5 30.5 PON1 PLG MIR199A1 MIR126 ACE
20 intermittent claudication 30.5 VWF SELP IL6 CRP ACE
21 cerebrovascular disease 30.4 SELP PON1 PLG PLAT P2RY12 MIR199A1
22 apnea, obstructive sleep 30.4 IL6 CRP APOE ACE
23 vascular dementia 30.4 PON1 IL6 APOE ACE
24 hypertriglyceridemia 1 30.4 APOE APOB APOA2
25 sickle cell anemia 30.4 VWF SELP IL6 F3 CRP
26 retinal vein occlusion 30.4 VWF IL6 F3 ACE
27 subclavian steal syndrome 30.3 F3 CRP ACE
28 sleep apnea 30.3 IL6 CRP APOE APOB ACE
29 aortic aneurysm, familial abdominal, 1 30.3 PLG MIR199A1 MIR126 IL6 F3 CRP
30 pulmonary disease, chronic obstructive 30.3 MIR199A1 MIR126 IL6 CRP ACE
31 hypertensive retinopathy 30.3 VWF CRP ACE
32 central retinal vein occlusion 30.3 PLG PLAT IL6 F3 CRP
33 cerebral artery occlusion 30.3 PLG PLAT IL6
34 peripheral vascular disease 30.3 VWF SELP PLG PLAT MIR126 LPA
35 head and neck cancer 30.3 MIR330 MIR199A1 MIR126 IL6
36 familial hypercholesterolemia 30.2 PON1 LPA APOE APOB APOA2
37 hyperuricemia 30.2 CRP APOE APOB
38 chronic kidney disease 30.2 VWF PON1 MIR126 LPA IL6 CRP
39 coronary heart disease 1 30.2 PON1 LPA CRP APOE APOB APOA2
40 bowel dysfunction 30.2 IL6 CRP ACE
41 moyamoya disease 1 30.2 VWF PLG PLAT MIR126 F3 CRP
42 ischemia 30.2 SELP PON1 PLG PLAT MIR126 IL6
43 papilledema 30.2 IL6 F3 CRP ACE
44 aortic valve disease 2 30.2 VWF MIR199A1 MIR126 LPA CRP APOB
45 renal artery disease 30.2 CRP ACE
46 fatty liver disease 30.1 IL6 CRP APOE APOB
47 infective endocarditis 30.1 VWF PLG IL6 F3 CRP ACE
48 vasculitis 30.1 VWF SELP IL6 CRP
49 temporal arteritis 30.1 VWF IL6 CRP ACE
50 peripheral artery disease 30.1 VWF SELP P2RY12 MIR199A1 MIR126 IL6

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to Carotid Artery Disease
Sources

Symptoms & Phenotypes for Carotid Artery Disease

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UMLS symptoms related to Carotid Artery Disease:


angina pectoris; chest pain; edema

GenomeRNAi Phenotypes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased free cholesterol GR00340-A-2 8.92 APOB APOE LPA SELP

MGI Mouse Phenotypes related to Carotid Artery Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.09 ACE APOA2 APOB APOE BLOC1S1 CRP
2 cellular MP:0005384 9.73 ACE APOB APOE BLOC1S1 F3 IL6
3 cardiovascular system MP:0005385 9.4 ACE APOB APOE CRP F3 IL6
Sources

Drugs & Therapeutics for Carotid Artery Disease

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PubMed Health treatment related to Carotid Artery Disease: 63

Treatments for carotid artery disease may include lifestyle changes, medicines, and medical procedures. The goals of treatment are to stop the disease from getting worse and to prevent a stroke . Your treatment will depend on your symptoms, how severe the disease is, and your age and overall health.

Drugs for Carotid Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 146)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Exenatide Approved, Investigational Phase 4 141758-74-9 45588096
2
Simvastatin Approved Phase 4 79902-63-9 54454
3
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
4
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
5
Metformin Approved Phase 4 1115-70-4, 657-24-9 4091
6
Dapagliflozin Approved Phase 4 461432-26-8 9887712
7
Glyburide Approved Phase 4 10238-21-8 3488
8
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
9
Evolocumab Approved Phase 4 1256937-27-5
10
Ezetimibe Approved Phase 4 163222-33-1 150311
11
Fenofibric acid Approved Phase 4 42017-89-0 64929
12
Fenofibrate Approved Phase 4 49562-28-9 3339
13
Atorvastatin Approved Phase 4 134523-00-5 60823
14
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
15
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
16
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
17
Choline Approved, Nutraceutical Phase 4 62-49-7 305
18 Hormones Phase 4
19 Hormone Antagonists Phase 4
20 Anti-Obesity Agents Phase 4
21 Incretins Phase 4
22 Vitamins Phase 4
23 Folate Phase 4
24 Vitamin B9 Phase 4
25 Vitamin B3 Phase 4
26 Trace Elements Phase 4
27 Nicotinic Acids Phase 4
28 Vasodilator Agents Phase 4
29 Vitamin B Complex Phase 4
30 Micronutrients Phase 4
31 Calcium, Dietary Phase 4
32 Analgesics Phase 4
33 Antirheumatic Agents Phase 4
34 Fibrinolytic Agents Phase 4
35 Antipyretics Phase 4
36 Cyclooxygenase Inhibitors Phase 4
37 Anti-Inflammatory Agents, Non-Steroidal Phase 4
38 Analgesics, Non-Narcotic Phase 4
39 Anti-Inflammatory Agents Phase 4
40 Colesevelam Hydrochloride Phase 4
41 Protective Agents Phase 4
42 Sodium-Glucose Transporter 2 Inhibitors Phase 4
43 Insulin, Globin Zinc Phase 4
44
Insulin Phase 4
45
Rosuvastatin Calcium Phase 4 147098-20-2
46 Bronchodilator Agents Phase 4
47 Anti-Asthmatic Agents Phase 4
48 Neuroprotective Agents Phase 4
49 Phosphodiesterase Inhibitors Phase 4
50 Phosphodiesterase 3 Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 201)
# Name Status NCT ID Phase Drugs
1 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
2 A 2-year, Open-label, Randomized Study to Evaluate the Efficacy of Rosuvastatin Dosing Adjustment by LDL-C Level Compared to That of 5mg Maintenance Dose in Chinese Patients With Carotid Atherosclerotic Plaques Unknown status NCT02532309 Phase 4 Rosuvastatin (5mg，10mg，20mg);Rosuvastatin 5mg
3 Effect of Bydureon on Carotid Atherosclerosis Progression in T2DM Unknown status NCT02162550 Phase 4 Bydureon;placebo
4 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
5 A Carotid Stenting Boston Scientific Surveillance Program Carotid WALLSTENT Monorail Endoprosthesis FilterWire EZâ„¢ Embolic Protection System Completed NCT00741091 Phase 4
6 Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWireâ„¢ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System Completed NCT00287508 Phase 4
7 Carotid Plaque Composition by Magnetic Resonance Imaging During Lipid Lowering Therapy Completed NCT00715273 Phase 4 Atorvastatin;Niacin;Colesevelam;Placebo Niacin;Placebo Colesevelam
8 Comparative Study of Dapagliflozin Versus Glibenclamide Effect on Endothelial Function of Coronary Artery Disease Patients Completed NCT02919345 Phase 4 Dapagliflozin 10 mg;Glibenclamide 5 mg
9 A Randomised Placebo-controlled Trial of Metformin on Progression of Carotid Atherosclerosis in Non-diabetic Patients With Cardiovascular Disease Treated With Conventional Risk Reducing Agents Completed NCT00723307 Phase 4 Metformin;Placebo
10 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
11 Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
12 Effect of Cilostazol, a Phosphodiesterase 3 Inhibitor, on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Completed NCT03248401 Phase 4 Cilostazol;Aspirin
13 Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima Media Thickness and Its Relation to Plaque Components of the Coronary Arteries in Patients With ST-Segment Elevation Acute Myocardial Infarction Completed NCT01203982 Phase 4 Rosuvastatin
14 CARotid plaqUe StabilizatiOn and Regression With Evolocumab: the CARUSO Study Recruiting NCT04730973 Phase 4 Evolocumab
15 Risk Assessment of Carotid Plaques Based on Pressure Estimation Using 3D Contrast-enhanced Ultrasound Recruiting NCT04643431 Phase 4
16 Effect of Atorvastatin and Omega 3 Combination Therapy on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes and Combined Dyslipidemia Recruiting NCT05365438 Phase 4 Omega 3-Atorvastatin;Atorvastatin-Ezetimibe
17 Effect of Choline Fenofibrate on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes and Combined Dyslipidemia Recruiting NCT05365425 Phase 4 Choline fenofibrate;Policosanol
18 Evaluation of the Effect of Atorvastatin and Pioglitazone in Carotid Atherosclerosis With the Use of 18Fluoride-Fludeoxyglucose(FDG) Positron Emission Tomography-computed Tomography (PET-CT)Imaging Terminated NCT01341730 Phase 4 Atorvastatin 20mg;Atorvastatin 20 mg + Pioglitazone 30 mg
19 INVESTIGATION of FLOW ALTERED, SHORT TRANSCERVICAL CAROTID ARTERY STENTING in PATIENTS With SIGNIFICANT CAROTID ARTERY DISEASE With Filter. Completed NCT01685567 Phase 3
20 Prospective, Non-Randomized, Multi-Center, Single-Arm Trial to Assess Safety & Efficacy of the Acculink Carotid Stent System With the Accunet Embolic Protection System in High-Risk Patients With Carotid Artery Lesions. Completed NCT00180518 Phase 2, Phase 3
21 Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy Completed NCT00231270 Phase 3
22 Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS) Completed NCT00231231 Phase 3
23 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
24 A 72-week, Prospective, Parallel-group, Partially Blinded, Controlled Phase IIIb Study Evaluating the Impact of Specific Lp(a) Apheresis on Atherosclerotic Disease Burden in Coronary Heart Disease Patients With High Lipoprotein(a) Level. Completed NCT02133807 Phase 3
25 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
26 Atherosclerosis Monitoring and Atherogenicity Reduction Study Completed NCT01734707 Phase 3 Placebo
27 The Effects of Lutein Supplementation on Subclinical Atherosclerosis Completed NCT01534533 Phase 2, Phase 3
28 A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction: A Double-Blind, Placebo Control Randomized Trial (BINOS) Recruiting NCT05126238 Phase 3 Lithium Carbonate;Placebo
29 A Prospective, Randomized, Open-Label, Pilot Study To Compare The Effect On Carotid Atherosclerosis Of A Tacrolimus-Based Regimen With Conversion From A Tacrolimus- To A Sirolimus-Based Regimen At 3-4 Months Post-Transplant In De Novo Renal Transplant Recipients Terminated NCT00311311 Phase 3 tacrolimus;mycophenolate mofetil;prednisone;sirolimus
30 99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques Withdrawn NCT03630835 Phase 2, Phase 3
31 Double-blinded Placebo-controlled Multicenter Study of Anti-atherosclerotic Activity of Inflaminat in Asymptomatic Participants With Subclinical Atherosclerosis Unknown status NCT01743404 Phase 2 Placebo
32 A Multi-centre, Randomised, Double-blind, Placebo-controlled, Parallel-group Study to Investigate the Effect of the Lp-PLA2 Inhibitor SB-480848 (40, 80mg od) on Carotid Plaque Composition in Patients With Carotid Artery Disease and Planned Carotid Endarterectomy, Stratified for Statin Use and Gender, After 14+/-4 Days Treatment Completed NCT01916720 Phase 2 SB-480848 40 mg;SB-480848 80 mg;Placebo
33 Carotid With Bivalirudin Angioplasty Completed NCT00812383 Phase 2
34 Effect of Valsartan on Endothelial Function, Oxidative Stress, Carotid Atherosclerosis, and Endothelial Progenitor Cells (EFFERVESCENT) Completed NCT00208767 Phase 2 Valsartan;Placebo
35 A Randomized Clinical Trial to Evaluate the Effects of High Dose Statin and Niacin Therapy on Excised Plaque Biomarkers in Patients Undergoing Carotid Endarterectomy (CEA) Completed NCT00804843 Phase 2 Atorvastatin/niacin extended-release;Atorvastatin;Simvastatin
36 Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques Completed NCT03871725 Phase 1, Phase 2
37 Effect of High Dose Vitamin E on Carotid Atherosclerosis Completed NCT00010699 Phase 2 Vitamin E
38 Multimodal Assessment of the Inflammatory Atheromatous Plaque : Comparison Between 68Ga-NODAGA-RGD PET/CT, 18F-FDG PET/CT, MRI AND US Recruiting NCT01608516 Phase 1, Phase 2
39 Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques Suspended NCT03382249 Phase 1, Phase 2
40 A Multi-Center, Open-Label, Dose-Finding, Feasibility Study of Optison in Contrast Enhanced U/S for the Detection of Carotid Artery Disease Terminated NCT01394926 Phase 2 Optison
41 An Exploratory, Phase II, Open Label, Single-Center, Non-Randomized Study Of [F-18] RGD-K5 Positron Emission Tomography (PET) In Participants With Carotid Artery Stenosis Terminated NCT01968226 Phase 2 [F-18] RDG-K5
42 Antioxidants and Prevention of Early Atherosclerosis Terminated NCT00000600 Phase 2 Vitamin E;Vitamin C
43 Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation Withdrawn NCT02995642 Phase 2 18F-FPPRGD2
44 Carotid Artery Plaque Intravascular Ultrasound Evaluation Completed NCT00271076 Phase 1
45 Phase I Study to Evaluated the Safety of Noninvasive Molecular Imaging for the Detection of Inflammation in Carotid Atherosclerotic Lesions by Using Ga-68-NOTA-MSA in Healthy Volunteers and Patients With Coronary Artery Disease Completed NCT01893489 Phase 1
46 PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis Completed NCT00547976 Phase 1 [C-11]PBR28
47 PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With [64]Cu-25%CANF-Comb Completed NCT02417688 Phase 1
48 Cytokine and Leukocyte Activation Profile as a Risk Factor for Cerebral Vascular Disease and Stroke Completed NCT00001368 Phase 1
49 Neuroinflammation in Asymptomatic Carotid Artery Disease - Imaging Substudy Recruiting NCT05238961 Phase 1 [18F]DPA-714
50 PET Detection of CCR2 in Human Atherosclerosis Recruiting NCT04537403 Phase 1 Group 1-64CU-DOTA-ECL1i (radioactive imaging medicine);Group 2 64CU-DOTA-ECL1i (radioactive imaging medicine)

Search NIH Clinical Center for Carotid Artery Disease

Cochrane evidence based reviews: carotid artery diseases

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Genetic Tests for Carotid Artery Disease

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Anatomical Context for Carotid Artery Disease

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Organs/tissues related to Carotid Artery Disease:

MalaCards : Brain, Heart, Lung, Endothelial, Kidney, Ovary, Smooth Muscle
Sources

Publications for Carotid Artery Disease

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Articles related to Carotid Artery Disease:

(show top 50) (show all 2380)
# Title Authors PMID Year
1
Is thyroid-stimulating hormone a predictor of severity of carotid artery disease? 62 41
36459014 2022
2
A clinical application study of a stent placement assessment. 41
36451472 2022
3
Association between cervical artery dissection and spinal manipulative therapy -a medicare claims analysis. 41
36447166 2022
4
Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease. 53 62
18073465 2008
5
TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease. 53 62
16474172 2006
6
The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status. 53 62
15995178 2005
7
Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. 53 62
12805074 2003
8
Relationship of early carotid artery disease with lipoprotein (a), apolipoprotein B, and fibrinogen in asymptomatic essential hypertensive patients and normotensive subjects. 53 62
11730086 2001
9
Ultrasonography Grading of Internal Carotid Artery Disease: Multiparametric German Society of Ultrasound in Medicine (DEGUM) versus Society of Radiologists in Ultrasound (SRU) Consensus Criteria. 62
33951737 2022
10
Studying plaque characteristics in extracranial carotid artery disease using CT angiography - Risk predictors beyond luminal stenosis. 62
36030729 2022
11
Correction to: State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease: the reporting-a consensus document by the European Society of Cardiovascular Radiology (ESCR). 62
36445481 2022
12
Atherosclerotic Carotid Artery Disease: Where to from the emergency room? University hospital experience. 62
36407697 2022
13
Correction to: State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease: standardization of scanning protocols and measurements-a consensus document by the European Society of Cardiovascular Radiology (ESCR). 62
36443436 2022
14
Predicting early mortality following single-stage coronary artery or valve surgery and carotid endarterectomy. 62
36349716 2022
15
Differentiation of Fibroblasts Into Myofibroblasts in the Arachnoid Membrane of Moyamoya Disease. 62
36039752 2022
16
Risk factors for stroke after carotid paraganglioma surgery. 62
36435423 2022
17
ABCD2, ABCD2-I, and OTTAWA scores for stroke risk assessment: a direct retrospective comparison. 62
35986834 2022
18
The role of non-stenosing carotid artery plaques in embolic stroke of undetermined source, is it a silent offender? A review of literature. 62
36451548 2022
19
Outcomes and Readmission in Patients With Retinal Artery Occlusion (from the Nationwide Readmission Database). 62
36115725 2022
20
3D-Arterial analysis software and CEUS in the assessment of severity and vulnerability of carotid atherosclerotic plaque: a comparison with CTA and histopathology. 62
36114929 2022
21
Cardiovascular/Stroke Risk Stratification in Diabetic Foot Infection Patients Using Deep Learning-Based Artificial Intelligence: An Investigative Study. 62
36431321 2022
22
Association between the rs2279238 of the Liver X receptor alpha gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort. 62
35907563 2022
23
The safety of carotid stenosis during vasodilator pharmacologic stress testing. 62
36207575 2022
24
Coexisting Coronary and Carotid Artery Disease: What We Did, What Happened. 62
35244376 2022
25
State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease: the reporting-a consensus document by the European Society of Cardiovascular Radiology (ESCR). 62
36194266 2022
26
Identifying High-Risk Nonstenotic Carotid Artery Disease. 62
36202451 2022
27
Extracellular matrix remodeling biomarkers in coronary artery disease. 62
36284400 2022
28
State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease: standardization of scanning protocols and measurements-a consensus document by the European Society of Cardiovascular Radiology (ESCR). 62
36194267 2022
29
A Novel Predictor of Contrast-Induced Nephropathy in Patients With Carotid Artery Disease; the Systemic Immune Inflammation Index. 62
35168409 2022
30
Ultrasound Evaluation of Carotid Artery Intima-Media Thickness: Effective Early Marker of Carotid Artery Disease in Adult Head and Neck Cancer Patients After Neck Radiation? 62
36199498 2022
31
Association of Neutrophil Extracellular Traps with Plaque Instability in Patient with Carotid Artery Stenosis. 62
35276352 2022
32
Risk factors in central retinal vein occlusion: A multi-center case-control study conducted on the Italian population : Demographic, environmental, systemic, and ocular factors that increase the risk for major thrombotic events in the retinal venous system. 62
34854784 2022
33
A Systematic Review and Bibliometric Analysis of Applications of Artificial Intelligence and Machine Learning in Vascular Surgery. 62
35339595 2022
34
Optimal periprocedural antithrombotic treatment in carotid interventions: An international, multispecialty, expert review and position statement. 62
36265593 2022
35
Combined Treatment With Carotid Endoarterectomy and Coronary Artery Bypass Grafting: A Single-Institutional Experience in 222 Patients. 62
35499500 2022
36
The effect of nutrition on stroke risk: A systematic review. 62
36040714 2022
37
Atherosclerosis of the carotid and coronary arteries in elderly patients with acute coronary syndrome. 62
36066986 2022
38
Predictive Value of Quantitative Duplex Ultrasound Analysis for In-stent Carotid Artery Restenosis. 62
35951073 2022
39
Predictive Factors for Major Adverse Cardiac and Cerebrovascular Events in Octogenarians after Elective Endovascular Aneurysm Repair. 62
36029948 2022
40
International Union of Angiology (IUA) consensus paper on imaging strategies in atherosclerotic carotid artery imaging: From basic strategies to advanced approaches. 62
35816927 2022
41
Nicotine Dependence and the Level of Motivation for Ceasing Smoking in the Case of Patients Undergoing Vascular Surgeries Versus the Optimisation of Perioperative Care-Pilot Survey. 62
36012032 2022
42
A systematic review and meta-analysis of sex- and gender-based differences in presentation severity and outcomes in adults undergoing major vascular surgery. 62
35257798 2022
43
Evolution of Extracranial Internal Carotid Artery Disease in Children With Sickle Cell Anemia. 62
35387492 2022
44
Reclassifications of ischemic stroke patterns due to variants of the Circle of Willis. 62
34569879 2022
45
Carotid Duplex Poorly Predicts Stroke Risk During Transcatheter Aortic Valve Replacement. 62
34995743 2022
46
Prevalence and Prognostic Impact of Carotid Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation. 62
35341937 2022
47
Carotid artery disease: knowing the numbers. 62
35938764 2022
48
Association of Plaque Inflammation With Stroke Recurrence in Patients With Unproven Benefit From Carotid Revascularization. 62
35418461 2022
49
Detecting the vulnerable carotid plaque: the Carotid Artery Multimodality imaging Prognostic study design. 62
35763768 2022
50
Benefits and drawbacks of statins and non-statin lipid lowering agents in carotid artery disease. 62
35605696 2022
Sources

Variations for Carotid Artery Disease

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Copy number variations for Carotid Artery Disease from CNVD:

6
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 49065 11 102660640 102668966 Copy number MMP1 Carotid artery disease
2 49067 11 102706527 102714342 Copy number MMP3 Carotid artery disease
3 163976 22 33196801 33259027 Copy number TIMP3 Carotid artery disease
4 207773 6 160952515 161087407 Copy number LPA Carotid artery disease
5 207774 6 160952515 161087407 Copy number LPAL2 Carotid artery disease
6 207775 6 160952515 161087407 Copy number PLG Carotid artery disease
Sources

Expression for Carotid Artery Disease

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Search GEO for disease gene expression data for Carotid Artery Disease.
Sources

Pathways for Carotid Artery Disease

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Pathways related to Carotid Artery Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.93 VWF SELP PLG PLAT P2RY12 F3
2
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 66
Show member pathways
 12.22 VWF PLG PLAT F3
3
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66
Show member pathways
 11.72 PLG IL6 APOE APOB APOA2
4
Statin inhibition of cholesterol production 74
Show member pathways
 11.46 APOE APOB APOA2
5
miRNAs involvement in the immune response in sepsis 74
11.34 MIR199A1 MIR126 IL6
6
Fibrin complement receptor 3 signaling pathway 74
11.07 PLG PLAT IL6
7
A-beta Plaque Formation and APP Metabolism 65
10.69 PLG PLAT ACE
8
Dissolution of Fibrin Clot 66
10.55 PLG PLAT
9
amb2 Integrin signaling 61
10.48 SELP PLG PLAT IL6 APOB
Sources

GO Terms for Carotid Artery Disease

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Cellular components related to Carotid Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.38 ACE APOA2 APOB APOE CRP F3
2 blood microparticle GO:0072562 10.01 PON1 PLG APOE APOA2
3 extracellular space GO:0005615 9.78 VWF SELP PON1 PLG PLAT MIR199A1
4 very-low-density lipoprotein particle GO:0034361 9.73 APOE APOB APOA2
5 intermediate-density lipoprotein particle GO:0034363 9.67 APOE APOB
6 chylomicron GO:0042627 9.63 APOA2 APOB APOE
7 high-density lipoprotein particle GO:0034364 9.56 PON1 APOE APOB APOA2

Biological processes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 9.92 APOA2 APOB APOE PON1
2 positive regulation of protein kinase B signaling GO:0051897 9.91 P2RY12 MIR199A1 MIR126 F3
3 lipid transport GO:0006869 9.85 LPA APOE APOB APOA2
4 cholesterol efflux GO:0033344 9.85 APOE APOB APOA2
5 high-density lipoprotein particle clearance GO:0034384 9.81 APOE APOA2
6 lipoprotein biosynthetic process GO:0042158 9.8 APOE APOB
7 lipoprotein catabolic process GO:0042159 9.78 APOE APOB
8 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.71 PLG PLAT
9 low-density lipoprotein particle remodeling GO:0034374 9.63 APOE APOB APOA2
10 blood coagulation GO:0007596 9.61 VWF PLG PLAT P2RY12 F3
11 lipoprotein metabolic process GO:0042157 9.56 APOE APOB APOA2
12 hemostasis GO:0007599 9.1 VWF PLG P2RY12 F3

Molecular functions related to Carotid Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 10.06 PLG PLAT LPA IL6 APOE APOA2
2 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.67 APOE APOA2
3 lipid transporter activity GO:0005319 9.65 APOE APOB APOA2
4 low-density lipoprotein particle receptor binding GO:0050750 9.63 APOB APOE CRP
5 cholesterol transfer activity GO:0120020 9.43 APOE APOB APOA2
6 phospholipid binding GO:0005543 9.32 PON1 F3 APOE APOB APOA2
Sources

Sources for Carotid Artery Disease

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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