MCID: CRT016
MIFTS: 57

Carotid Artery Disease

Categories: Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Carotid Artery Disease

MalaCards integrated aliases for Carotid Artery Disease:

Name: Carotid Artery Disease 12 43 15 63
Carotid Artery Diseases 55 44 73
Disorder of Carotid Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3407
MeSH 44 D002340
NCIt 50 C84476
SNOMED-CT 68 371160000
ICD10 33 G45.1
UMLS 73 C0007273

Summaries for Carotid Artery Disease

MedlinePlus : 43 Your carotid arteries are two large blood vessels in your neck. They supply your brain and head with blood. If you have carotid artery disease, the arteries become narrow or blocked, usually because of atherosclerosis. Atherosclerosis is the buildup of plaque, which is made up of fat, cholesterol, calcium, and other substances found in the blood. Carotid artery disease is serious because it can block the blood flow to your brain, causing a stroke. Too much plaque in the artery can cause a blockage. You can also have a blockage when a piece of plaque or a blood clot breaks off the wall of an artery. The plaque or clot can travel through the bloodstream and get stuck in one of your brain's smaller arteries. Carotid artery disease often does not cause symptoms until the blockage or narrowing is severe. One sign may be a bruit (whooshing sound) that your doctor hears when listening to your artery with a stethoscope. Another sign is a transient ischemic attack (TIA), a "mini-stroke." A TIA is like a stroke, but it only lasts a few minutes, and the symptoms usually go away within an hour. Stroke is another sign. Imaging tests can confirm whether you have carotid artery disease. Treatments may include Healthy lifestyle changes Medicines Carotid endarterectomy, surgery to remove the plaque Angioplasty, a procedure to place a balloon and stent into the artery to open it and hold it open NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Carotid Artery Disease, also known as carotid artery diseases, is related to amaurosis fugax and atherosclerosis susceptibility, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Carotid Artery Disease is APOB (Apolipoprotein B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. The drugs Clopidogrel and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

PubMed Health : 63 About carotid artery disease: Carotid (ka-ROT-id) artery disease is a disease in which a waxy substance called plaque (plak) builds up inside the carotid arteries. You have two common carotid arteries, one on each side of your neck. They each divide into internal and external carotid arteries.The internal carotid arteries supply oxygen-rich blood to your brain. The external carotid arteries supply oxygen-rich blood to your face, scalp, and neck.

Related Diseases for Carotid Artery Disease

Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 amaurosis fugax 30.4 MMP8 MMP9
2 atherosclerosis susceptibility 30.1 APOA1 APOB APOE CCL2 CRP LPA
3 sleep apnea 30.0 ACE APOE CRP
4 peripheral artery disease 30.0 ACE APOB CCL2 CRP
5 carotid stenosis 29.5 ACE APOE CRP MMP1 MMP9
6 acute myocardial infarction 29.1 ACE APOA1 CRP MMP9 PLG
7 kidney disease 29.0 ACE APOE CCL2 CRP LPA
8 heart disease 29.0 ACE APOA1 APOB APOE CRP
9 cerebrovascular disease 28.2 ACE APOA1 APOB APOE CRP MMP9
10 peripheral vascular disease 27.9 ACE APOA1 APOB CRP LPA SELE
11 diabetes mellitus 27.9 ACE APOA1 APOB COG2 CRP LPA
12 hypertension, essential 27.7 ACE APOA1 APOB CRP LPA SELE
13 aortic aneurysm, familial abdominal, 1 27.6 APOE CCL2 CRP MMP1 MMP8 MMP9
14 arteries, anomalies of 27.0 ACE APOA1 APOB APOE CCL2 COG2
15 stroke, ischemic 26.8 ACE APOB APOE COG2 CRP LPA
16 vascular disease 25.9 ACE APOA1 APOB APOE CCL2 CRP
17 coronary artery anomaly 24.8 ACE APOA1 APOB APOE CCL2 COG2
18 myocardial infarction 24.7 ACE APOA1 APOB APOE CCL2 COG2
19 xanthoma disseminatum 10.9 APOB APOE
20 hypercholesterolemia, autosomal dominant, type b 10.8 APOB APOE
21 defective apolipoprotein b-100 10.8 APOB APOE
22 familial lcat deficiency 10.8 APOA1 APOE
23 moderate and severe traumatic brain injury 10.7 ACE APOE
24 chronic meningitis 10.7 CRP MMP9
25 blue toe syndrome 10.7 CRP PLG
26 spastic entropion 10.7 MMP1 MMP9
27 lipoprotein glomerulopathy 10.7 APOB APOE LPA
28 hepatic lipase deficiency 10.7 APOA1 APOE
29 chronic actinic dermatitis 10.7 MMP1 MMP9
30 acute transverse myelitis 10.6 APOA1 MMP9
31 xanthomatosis 10.6 APOB APOE LPA
32 acute anterolateral myocardial infarction 10.6 ACE PLG
33 hypobetalipoproteinemia, familial, 1 10.6 APOA1 APOB APOE
34 hyperlipoproteinemia, type iv 10.6 APOA1 APOB APOE
35 amyloidosis aa 10.6 APOA1 CRP LPA
36 dysbaric osteonecrosis 10.6 APOA1 APOB PLG
37 hyperalphalipoproteinemia 1 10.6 APOA1 APOB APOE
38 internal hemorrhoid 10.6 MMP1 MMP9
39 abetalipoproteinemia 10.6 APOA1 APOB APOE
40 autoimmune inner ear disease 10.6 MMP9 TIMP1
41 gallbladder disease 10.5 APOA1 APOB APOE
42 head injury 10.5 APOE THBD
43 pyosalpinx 10.5 APOE CRP
44 chronic venous leg ulcers 10.5 MMP9 TIMP1
45 generalized atherosclerosis 10.5 ACE APOE CRP
46 pelvic inflammatory disease 10.5 CCL2 CRP MMP9
47 aortic valve disease 1 10.4 ACE APOB CRP
48 aortic atherosclerosis 10.4 ACE APOE LPA
49 intermediate coronary syndrome 10.4 ACE CRP PLG
50 respiratory system disease 10.4 CCL2 CRP MMP9

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to Carotid Artery Disease

Symptoms & Phenotypes for Carotid Artery Disease

UMLS symptoms related to Carotid Artery Disease:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Carotid Artery Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 THBD TIMP1 SELE CD163 COG2 SLC39A2
2 cardiovascular system MP:0005385 10.14 THBD TIMP1 SELE CD163 CRP ACE
3 growth/size/body region MP:0005378 10.07 SLC39A2 THBD TIMP1 APOE PLG SELE
4 immune system MP:0005387 10.07 THBD TIMP1 CCL2 SELE CD163 CRP
5 liver/biliary system MP:0005370 9.76 SLC39A2 THBD SELE ACE APOA1 APOB
6 neoplasm MP:0002006 9.43 TIMP1 PLG MMP1 ACE MMP8 MMP9
7 respiratory system MP:0005388 9.17 THBD TIMP1 APOE CD163 SELE MMP9

Drugs & Therapeutics for Carotid Artery Disease

PubMedHealth treatment related to Carotid Artery Disease: 63

Treatments for carotid artery disease may include lifestyle changes, medicines, and medical procedures. The goals of treatment are to stop the disease from getting worse and to prevent a stroke.Your treatment will depend on your symptoms, how severe the disease is, and your age and overall health.

Drugs for Carotid Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 228)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
2
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
4
Simvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 79902-63-9 54454
5
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
6
Metformin Approved Phase 4,Not Applicable 657-24-9 14219 4091
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Remifentanil Approved Phase 4 132875-61-7 60815
9
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
10
Acetaminophen Approved Phase 4 103-90-2 1983
11
Angiotensin II Approved, Investigational Phase 4,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
12
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
13
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
14
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
15
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
16
Glyburide Approved Phase 4 10238-21-8 3488
17
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
18
Losartan Approved Phase 4 114798-26-4 3961
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 59-30-3 6037
20
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 59-67-6 938
21
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 98-92-0 936
22
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
23 tannic acid Approved, Nutraceutical Phase 4,Phase 3
24 Anticholesteremic Agents Phase 4,Phase 3,Phase 2,Not Applicable
25 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
26 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
27 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
28 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
29 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Rosuvastatin Calcium Phase 4,Phase 3,Not Applicable 147098-20-2
31 Atorvastatin Calcium Phase 4,Phase 3,Phase 2,Not Applicable 134523-03-8
32 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
33 Fibrinolytic Agents Phase 4,Phase 2,Phase 3,Not Applicable
34 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Purinergic P2 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
37 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
38 Micronutrients Phase 4,Phase 2,Not Applicable
39 Trace Elements Phase 4,Phase 2,Not Applicable
40 Vitamins Phase 4,Phase 2,Not Applicable
41 Hypoglycemic Agents Phase 4,Not Applicable
42 Central Nervous System Depressants Phase 4,Not Applicable
43 Protective Agents Phase 4,Phase 2,Phase 3,Not Applicable
44 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
45 Anesthetics Phase 4,Phase 1,Phase 2,Not Applicable
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
47 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Not Applicable
48 Antipyretics Phase 4,Phase 3,Phase 2,Not Applicable
49 Anti-Asthmatic Agents Phase 4,Not Applicable
50 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 332)
# Name Status NCT ID Phase Drugs
1 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
2 A Study to Evaluate the Efficacy and Safety of Rosuvastatin in the Treatment of the Carotid Atherosclerotic Plaques Unknown status NCT02532309 Phase 4 Rosuvastatin (5mg,10mg,20mg);Rosuvastatin 5mg
3 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
4 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
5 A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
6 Carotid Revascularization With ev3 Arterial Technology Evolution Post Approval Study Completed NCT00530504 Phase 4
7 A Carotid Stenting Boston Scientific Surveillance Program Completed NCT00741091 Phase 4
8 Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study) Completed NCT00287508 Phase 4
9 Carotid Atherosclerosis Regression at Magnetic Resonance Assessment. Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
10 The Effect of Atorvastatin and Pioglitazone on Carotid Atherosclerosis With the Use of Positron Emission Tomography-computed Tomography (PET-CT) Completed NCT01341730 Phase 4 Atorvastatin 20mg;Atorvastatin 20 mg + Pioglitazone 30 mg
11 Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT) Completed NCT01203982 Phase 4 Rosuvastatin;Rosuvastatin
12 Carotid Atherosclerosis: MEtformin for Insulin ResistAnce Study Completed NCT00723307 Phase 4 Metformin;Placebo
13 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
14 Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
15 Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy Completed NCT02609087 Phase 4 Sevoflurane;Propofol
16 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
17 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
18 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
19 Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Recruiting NCT03248401 Phase 4 Cilostazol;Aspirin
20 High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
21 Insulin Resistance in Patients After Carotid Revascularization Recruiting NCT03419767 Phase 4 Melatonin
22 Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication Active, not recruiting NCT00715273 Phase 4 Atorvastatin;Niacin;Colesevelam;Placebo Niacin;Placebo Colesevelam
23 Carotid Artery Stenting With Cilostazol Addition for Restenosis Active, not recruiting NCT01261234 Phase 4 Cilostazol or Non-Cilostazol
24 Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus Active, not recruiting NCT02162550 Phase 4 Bydureon;placebo
25 Assessment of Dapagliflozin Effect on Diabetic Endothelial Dysfunction of Brachial Artery Not yet recruiting NCT02919345 Phase 4 Dapagliflozin 10 mg;Glibenclamide 5 mg
26 Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA Terminated NCT00478673 Phase 4
27 The Effects of Dexmedetomidine and Remifentanil on Carotid Patients Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
28 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
29 Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
30 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting Unknown status NCT01331473 Phase 3
31 Safety and Efficacy Study for Reverse Flow Used During Carotid Artery Stenting Procedure Completed NCT01685567 Phase 3
32 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
33 Carotid With Bivalirudin Angioplasty Completed NCT00812383 Phase 2, Phase 3
34 Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) Completed NCT00231270 Phase 3
35 Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS) Completed NCT00231231 Phase 3
36 Silk Road Medical First in Man Study - Neuroprotection During Carotid Stenting and Angioplasty Completed NCT01264419 Phase 3
37 ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial" Completed NCT00180518 Phase 2, Phase 3
38 Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis Completed NCT02133807 Phase 3
39 Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
40 Atherosclerosis Monitoring and Atherogenicity Reduction Study Completed NCT01734707 Phase 3 Placebo
41 Effects of Lutein Supplementation on Subclinical Atherosclerosis Completed NCT01534533 Phase 2, Phase 3
42 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
43 IMaging Della PLAcca Carotidea Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
44 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (EMBOLDEN) Completed NCT00766493 Phase 3
45 GORE Embolic Protection With Reverse Flow Completed NCT00594100 Phase 3
46 Gadobutrol Enhanced MRA of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
47 ViVEXX Carotid Revascularization Trial (VIVA) Completed NCT00417963 Phase 3
48 Carotid Artery Stenting With Protection Registry Completed NCT00318851 Phase 3
49 SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy Completed NCT01591005 Phase 3
50 Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3

Search NIH Clinical Center for Carotid Artery Disease

Cochrane evidence based reviews: carotid artery diseases

Genetic Tests for Carotid Artery Disease

Anatomical Context for Carotid Artery Disease

MalaCards organs/tissues related to Carotid Artery Disease:

41
Brain, Heart, Testes, Lung, Endothelial, Kidney, Ovary

Publications for Carotid Artery Disease

Articles related to Carotid Artery Disease:

(show top 50) (show all 604)
# Title Authors Year
1
Epicardial adipose tissue and carotid artery disease: Protocol for systematic review and meta-analysis. ( 29702973 )
2018
2
Validation of Multiparametric Ultrasonography Criteria with Digital Subtraction Angiography in Carotid Artery Disease: A Prospective Multicenter Study. ( 29797307 )
2018
3
The Role of Neurosonology in the Diagnosis and Management of Patients with Carotid Artery Disease: A Review. ( 29334161 )
2018
4
Ischemic stroke/transient ischemic attack events and carotid artery disease in the absence of or with minimal coronary artery calcification: Results from the Multi-Ethnic Study of Atherosclerosis. ( 29852401 )
2018
5
Flip-Flop Phenomenon: Swallowing-Induced Arterial Displacement as an Indicator of Carotid Artery Disease. ( 29879697 )
2018
6
Neovascularization in Vertebral Artery Atheroma-A Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Comparative Study in Patients with Symptomatic and Asymptomatic Carotid Artery Disease. ( 29805083 )
2018
7
Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia. ( 29922933 )
2018
8
Rivaroxaban plus aspirin, compared with aspirin alone, reduced cardiovascular events in patients with stable peripheral or carotid artery disease, but increased the risk of major bleeding. ( 29650723 )
2018
9
Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial. ( 29389037 )
2018
10
Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique? ( 29405657 )
2018
11
Regional variation in patient outcomes in carotid artery disease treatment in the Vascular Quality Initiative. ( 29571620 )
2018
12
Looking beyond luminal stenosis in carotid artery disease. ( 29622453 )
2018
13
Renin and aldosterone are not associated with vulnerable plaque characteristics in patients with carotid artery disease. ( 29548814 )
2018
14
Transcarotid Transcatheter Aortic Valve Replacement as Preferred Alternative Access in a Patient With Bilateral Carotid Artery Disease. ( 29289952 )
2018
15
The role of microwave radiometry in carotid artery disease. Diagnostic and clinical prospective. ( 29631128 )
2018
16
Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease. ( 28776469 )
2017
17
Carotid artery disease and neurocognitive impairment. ( 28560985 )
2017
18
Endovascular prevention and treatment of stroke related to extracranial carotid artery disease. ( 27922251 )
2017
19
Chronic arsenic exposure and risk of carotid artery disease: The Strong Heart Study. ( 28554006 )
2017
20
Biobanking in carotid artery disease: translation to clinical practice. ( 28051291 )
2017
21
The association of the circle of Willis anomaly and risk of stroke in patients with carotid artery disease. ( 28746428 )
2017
22
Higher Daily Physical Activity Level Is Associated with Lower RBC Aggregation in Carotid Artery Disease Patients at High Risk of Stroke. ( 29311973 )
2017
23
Carotid Artery Disease as a Predictor of In-Hospital Postoperative Stroke After Coronary Artery Bypass Grafting From 1999 to 2011. ( 29169797 )
2017
24
Hybrid Treatment of Extracranial Carotid Artery Disease. ( 28604285 )
2017
25
Carotid artery disease and periprocedural stroke risk after transcatheter aortic valve implantation. ( 28393772 )
2017
26
Magnetic Resonance Imaging Plaque Hemorrhage for Risk Stratification in Carotid Artery Disease With Moderate Risk Under Current Medical Therapy. ( 28196937 )
2017
27
Selective-versus-Standard Poststent Dilation for Carotid Artery Disease: A Systematic Review and Meta-Analysis. ( 28302610 )
2017
28
Effects of Obstructive Carotid Artery Disease on Ocular Circulation and the Safety of Carotid Artery Stenting. ( 28162948 )
2017
29
Contemporary Management of Patients with Concomitant Coronary and Carotid Artery Disease. ( 28785837 )
2017
30
Carotid Duplex Ultrasonography: Additional Imaging Is Rarely Necessary for Appropriate Treatment Planning for Carotid Artery Disease. ( 28424133 )
2017
31
Approach to concurrent coronary and carotid artery disease: Epidemiology, screening and treatment. ( 29451667 )
2017
32
Spectral Domain Optical Coherence Tomography Findings in Carotid Artery Disease. ( 29326849 )
2017
33
Carotid artery disease and neurocognitive impairment. ( 28560984 )
2017
34
Contemporary medical therapies of atherosclerotic carotid artery disease. ( 28818261 )
2017
35
OCULAR ARTERIAL OCCLUSIVE DISORDERS AND CAROTID ARTERY DISEASE. ( 28547004 )
2017
36
Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative. ( 28359719 )
2017
37
Concomitant Surgical Treatment of Symptomatic Carotid Artery Disease With a Coexisting Shamblin I Carotid Body Tumor. ( 28118794 )
2017
38
Paraoxonase-1: Characteristics and role in atherosclerosis and carotid artery disease. ( 29189170 )
2017
39
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. ( 29132880 )
2017
40
Symptomatic Carotid Artery Disease: Revascularization. ( 28442330 )
2017
41
Carotid artery disease and perioperative stroke risk after surgical aortic valve replacement: A nationwide inpatient sample analysis. ( 28454636 )
2017
42
Lower extremity and carotid artery disease in COPD. ( 28053972 )
2016
43
Surgical Versus Percutaneous Therapy of Carotid Artery Disease: An Evidence-Based Outcomes Analysis. ( 27712968 )
2016
44
Expression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease. ( 26799121 )
2016
45
White Matter Diffusion Abnormalities in Carotid Artery Disease: A Systematic Review and Meta-Analysis. ( 27079165 )
2016
46
Multi-parametric ultrasound criteria for internal carotid artery disease-comparison with CT angiography. ( 27230916 )
2016
47
Prevalence of Carotid Artery Disease among Ambulatory Patients with Coronary Artery Disease. ( 26979002 )
2016
48
Neurocognitive Improvement in Patients Undergoing Carotid Endarterectomy for Atherosclerotic Occlusive Carotid Artery Disease. ( 28018503 )
2016
49
Initial experience with the inspire MD C-Guard stent in the treatment of carotid artery disease. ( 27094426 )
2016
50
Carotid artery disease progression and related neurologic events after carotid endarterectomy. ( 27021378 )
2016

Variations for Carotid Artery Disease

Copy number variations for Carotid Artery Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 49065 11 102660640 102668966 Copy number MMP1 Carotid artery disease
2 49067 11 102706527 102714342 Copy number MMP3 Carotid artery disease
3 163976 22 33196801 33259027 Copy number TIMP3 Carotid artery disease
4 207773 6 160952515 161087407 Copy number LPA Carotid artery disease
5 207774 6 160952515 161087407 Copy number LPAL2 Carotid artery disease
6 207775 6 160952515 161087407 Copy number PLG Carotid artery disease

Expression for Carotid Artery Disease

Search GEO for disease gene expression data for Carotid Artery Disease.

Pathways for Carotid Artery Disease

Pathways related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 APOA1 APOB MMP1 PLG SELE THBD
2
Show member pathways
12.62 MMP1 MMP8 MMP9 PLG TIMP1
3
Show member pathways
12.45 APOA1 APOB APOE LPA
4
Show member pathways
12.1 APOB MMP1 SELE THBD
5 11.98 CCL2 MMP9 SELE THBD
6
Show member pathways
11.9 APOA1 APOB APOE LPA
7 11.87 CCL2 MMP1 MMP9 TIMP1
8 11.81 CCL2 MMP9 SELE
9
Show member pathways
11.81 APOA1 APOB APOE CD163
10 11.77 CCL2 SELE THBD
11 11.72 CCL2 MMP9 TIMP1
12 11.56 CCL2 MMP9 TIMP1
13
Show member pathways
11.55 MMP1 MMP9 SELE
14 11.49 MMP1 MMP9 PLG TIMP1
15
Show member pathways
11.43 APOA1 APOB APOE CCL2 CRP PLG
16 11.35 APOB LPA MMP9 PLG
17
Show member pathways
11.35 MMP1 MMP8 MMP9 PLG TIMP1
18 11.21 MMP1 MMP9 PLG SELE
19 11.09 CCL2 MMP1 MMP9 THBD
20 11.05 CCL2 MMP9 TIMP1
21 10.99 ACE MMP9 PLG
22 10.96 ACE APOE CCL2 MMP9
23 10.94 MMP1 PLG
24 10.89 CCL2 MMP1 TIMP1
25 10.84 MMP1 MMP9

GO Terms for Carotid Artery Disease

Cellular components related to Carotid Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.78 APOA1 APOB APOE TIMP1
2 extracellular region GO:0005576 9.77 ACE APOA1 APOB APOE CCL2 CD163
3 extracellular matrix GO:0031012 9.73 APOA1 APOE MMP1 MMP8 MMP9 TIMP1
4 very-low-density lipoprotein particle GO:0034361 9.61 APOA1 APOB APOE
5 endocytic vesicle lumen GO:0071682 9.58 APOA1 APOB APOE
6 low-density lipoprotein particle GO:0034362 9.54 APOA1 APOB APOE
7 chylomicron GO:0042627 9.5 APOA1 APOB APOE
8 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
9 extracellular space GO:0005615 9.4 ACE APOA1 APOB APOE CCL2 CRP
10 intermediate-density lipoprotein particle GO:0034363 9.33 APOA1 APOB APOE

Biological processes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.98 APOA1 APOB APOE TIMP1
2 cytokine-mediated signaling pathway GO:0019221 9.96 CCL2 MMP1 MMP9 TIMP1
3 platelet degranulation GO:0002576 9.85 APOA1 PLG TIMP1
4 steroid metabolic process GO:0008202 9.85 APOA1 APOB APOE
5 receptor-mediated endocytosis GO:0006898 9.85 APOA1 APOB APOE CD163
6 cholesterol metabolic process GO:0008203 9.81 APOA1 APOB APOE
7 cholesterol homeostasis GO:0042632 9.81 APOA1 APOB APOE
8 lipid transport GO:0006869 9.8 APOA1 APOB APOE LPA
9 leukocyte migration GO:0050900 9.8 APOB MMP1 MMP9 SELE THBD
10 collagen catabolic process GO:0030574 9.76 MMP1 MMP8 MMP9
11 retinoid metabolic process GO:0001523 9.73 APOA1 APOB APOE
12 reverse cholesterol transport GO:0043691 9.67 APOA1 APOE
13 high-density lipoprotein particle remodeling GO:0034375 9.66 APOA1 APOE
14 positive regulation of lipid biosynthetic process GO:0046889 9.65 APOA1 APOE
15 negative regulation of blood coagulation GO:0030195 9.65 APOE THBD
16 high-density lipoprotein particle assembly GO:0034380 9.65 APOA1 APOE
17 triglyceride catabolic process GO:0019433 9.65 APOA1 APOB APOE
18 phospholipid efflux GO:0033700 9.64 APOA1 APOE
19 negative regulation of fibrinolysis GO:0051918 9.63 PLG THBD
20 cholesterol efflux GO:0033344 9.63 APOA1 APOB APOE
21 very-low-density lipoprotein particle remodeling GO:0034372 9.62 APOA1 APOE
22 positive regulation of cholesterol esterification GO:0010873 9.62 APOA1 APOE
23 high-density lipoprotein particle clearance GO:0034384 9.61 APOA1 APOE
24 negative regulation of platelet activation GO:0010544 9.61 APOE THBD
25 lipoprotein metabolic process GO:0042157 9.61 APOA1 APOB APOE
26 neuron projection regeneration GO:0031102 9.6 APOA1 APOE
27 chylomicron remnant clearance GO:0034382 9.59 APOB APOE
28 regulation of cholesterol transport GO:0032374 9.58 APOA1 APOE
29 regulation of Cdc42 protein signal transduction GO:0032489 9.57 APOA1 APOE
30 very-low-density lipoprotein particle clearance GO:0034447 9.54 APOB APOE
31 low-density lipoprotein particle remodeling GO:0034374 9.54 APOB APOE LPA
32 lipoprotein catabolic process GO:0042159 9.51 APOB APOE
33 chylomicron assembly GO:0034378 9.5 APOA1 APOB APOE
34 chylomicron remodeling GO:0034371 9.43 APOA1 APOB APOE
35 cellular protein metabolic process GO:0044267 9.43 APOA1 APOB APOE MMP1 PLG TIMP1
36 lipoprotein biosynthetic process GO:0042158 9.33 APOA1 APOB APOE
37 extracellular matrix disassembly GO:0022617 9.02 MMP1 MMP8 MMP9 PLG TIMP1
38 proteolysis GO:0006508 10 ACE LPA MMP1 MMP8 MMP9 PLG

Molecular functions related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.85 ACE LPA MMP1 MMP8 MMP9 PLG
2 serine-type endopeptidase activity GO:0004252 9.72 LPA MMP1 MMP8 MMP9 PLG
3 metallopeptidase activity GO:0008237 9.71 ACE MMP1 MMP8 MMP9
4 metalloendopeptidase activity GO:0004222 9.69 MMP1 MMP8 MMP9
5 phospholipid binding GO:0005543 9.65 APOA1 APOB APOE
6 apolipoprotein binding GO:0034185 9.49 LPA PLG
7 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.46 APOA1 APOE
8 lipoprotein particle binding GO:0071813 9.43 APOA1 APOE
9 lipid transporter activity GO:0005319 9.43 APOA1 APOB APOE
10 low-density lipoprotein particle receptor binding GO:0050750 9.33 APOB APOE CRP
11 endopeptidase activity GO:0004175 9.26 ACE MMP1 MMP9 PLG
12 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE

Sources for Carotid Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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