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MCID: CRT008
MIFTS: 38

Carotid Artery Dissection

Categories: Cardiovascular diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Carotid Artery Dissection

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MalaCards integrated aliases for Carotid Artery Dissection:

Name: Carotid Artery Dissection 12 77 6 15 74
Dissection of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9348
ICD9CM 36 443.21
NCIt 51 C125662
ICD10 34 I77.71
UMLS 74 C0338585
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Summaries for Carotid Artery Dissection

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MalaCards based summary : Carotid Artery Dissection, also known as dissection of carotid artery, is related to horner's syndrome and familial cervical artery dissection. An important gene associated with Carotid Artery Dissection is LDLR (Low Density Lipoprotein Receptor), and among its related pathways/superpathways are Development VEGF signaling via VEGFR2 - generic cascades and Metabolism of fat-soluble vitamins. The drugs Clopidogrel and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and liver, and related phenotypes are Increased transferrin (TF) endocytosis and Reduced mammosphere formation

Wikipedia : 77 Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing... more...

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Related Diseases for Carotid Artery Dissection

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Diseases related to Carotid Artery Dissection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 horner's syndrome 10.6
2 familial cervical artery dissection 10.5
3 headache 10.5
4 stroke, ischemic 10.4
5 cluster headache 10.3
6 fibromuscular dysplasia 10.2
7 eagle syndrome 10.2
8 cerebral artery occlusion 10.1
9 branch retinal artery occlusion 10.1
10 retinal artery occlusion 10.1
11 takayasu arteritis 10.1
12 central retinal artery occlusion 10.1
13 neuropathy 10.1
14 hemicrania continua 10.1
15 systemic lupus erythematosus 10.0
16 migraine with or without aura 1 10.0
17 yemenite deaf-blind hypopigmentation syndrome 10.0
18 middle cerebral artery infarction 10.0
19 intracranial aneurysm 10.0
20 pertussis 10.0
21 pituitary apoplexy 10.0
22 optic nerve disease 10.0
23 essential thrombocythemia 10.0
24 syphilis 10.0
25 kidney disease 10.0
26 lupus erythematosus 10.0
27 polycystic kidney disease 10.0
28 reversible cerebral vasoconstriction syndrome 10.0
29 whiplash 10.0
30 cerebral aneurysms 10.0
31 dysphagia 10.0
32 encephalopathy 10.0
33 cerebral amyloid angiopathy, cst3-related 9.8
34 behcet syndrome 9.8
35 intussusception 9.8
36 macroglossia 9.8
37 marfan syndrome 9.8
38 polycystic liver disease 1 with or without kidney cysts 9.8
39 arterial tortuosity syndrome 9.8
40 homocystinuria due to cystathionine beta-synthase deficiency 9.8
41 moyamoya disease 1 9.8
42 graves disease 1 9.8
43 brittle bone disorder 9.8
44 alpha-1-antitrypsin deficiency 9.8
45 brain injury 9.8
46 ischemic optic neuropathy 9.8
47 liver disease 9.8
48 osteoarthritis 9.8
49 traumatic brain injury 9.8
50 polycystic liver disease 9.8

Graphical network of the top 20 diseases related to Carotid Artery Dissection:



Diseases related to Carotid Artery Dissection
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Symptoms & Phenotypes for Carotid Artery Dissection

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GenomeRNAi Phenotypes related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.35 ACADS GAA GPC3 LDLR RNF213
2 Reduced mammosphere formation GR00396-S 8.8 ACADS GAA LDLR

MGI Mouse Phenotypes related to Carotid Artery Dissection:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.26 GAA GPC3 LDLR RNF213
2 homeostasis/metabolism MP:0005376 9.02 ACADS GAA GPC3 LDLR RNF213
Sources

Drugs & Therapeutics for Carotid Artery Dissection

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Drugs for Carotid Artery Dissection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
2
Dalteparin Approved Phase 3 9005-49-6
3
Dipyridamole Approved Phase 3 58-32-2 3108
4
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
5
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
6
Warfarin Approved Phase 3 81-81-2 54678486 6691
7
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
8
Enoxaparin Approved Phase 3 9005-49-6 772
9
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
10 Antipyretics Phase 3
11 Peripheral Nervous System Agents Phase 3
12 Purinergic P2 Receptor Antagonists Phase 3
13 Platelet Aggregation Inhibitors Phase 3
14 Fibrinolytic Agents Phase 3
15 Calcium, Dietary Phase 3
16 Antirheumatic Agents Phase 3
17 Neurotransmitter Agents Phase 3
18 Vasodilator Agents Phase 3
19 Analgesics Phase 3
20 calcium heparin Phase 3
21 Coagulants Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Phosphodiesterase Inhibitors Phase 3
24 Cyclooxygenase Inhibitors Phase 3
25 Analgesics, Non-Narcotic Phase 3
26 Anti-Inflammatory Agents, Non-Steroidal Phase 3
27 Purinergic P2Y Receptor Antagonists Phase 3
28 Heparin, Low-Molecular-Weight Phase 3
29 Anticoagulants Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection Completed NCT00238667 Phase 3 Antiplatelet (Aspirin, Dipyridamole, clopidogrel);Anticoagulant (Unfractionated Heparin, LMW Heparin, Warfarin)
2 Pupillometry in Horner's Syndrome Recruiting NCT02978079 Not Applicable

Search NIH Clinical Center for Carotid Artery Dissection

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Genetic Tests for Carotid Artery Dissection

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Anatomical Context for Carotid Artery Dissection

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MalaCards organs/tissues related to Carotid Artery Dissection:

42
Brain, Kidney, Liver, Bone, Pituitary, Testes, Tongue
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Publications for Carotid Artery Dissection

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Articles related to Carotid Artery Dissection:

(show top 50) (show all 620)
# Title Authors Year
1
Internal carotid artery dissection causing pulsatile tinnitus. ( 30241776 )
2019
2
Global Orbital Infarction Syndrome After a Carotid Artery Dissection. ( 30285037 )
2019
3
Bilateral Vertebral Artery Dissection and Unilateral Carotid Artery Dissection in Case of Ehlers-Danlos Syndrome Type IV. ( 30315974 )
2019
4
Management of a pregnancy with underlying fibromuscular dysplasia with a history of stroke and carotid artery dissection. ( 30417729 )
2019
5
Unusual case of traumatic cervical internal carotid artery dissection presenting as pseudofenestration. ( 30612106 )
2019
6
A Case of Bilateral Extracranial Internal Carotid Artery Dissection Due to the Helmet Strap After Motorcycle Crash. ( 30624242 )
2019
7
False Aneurysms Complicating Internal Carotid Artery Dissection. ( 30630394 )
2019
8
Hypoglossal nerve palsy due to carotid artery dissection: an uncommon presentation of a common problem. ( 30648931 )
2019
9
Surgical treatment of spontaneous internal carotid artery dissection with abducent nerve palsy: A case report and review of literature. ( 30711658 )
2019
10
Internal carotid artery dissection causing ischemic stroke during pole sport practice. ( 30758162 )
2019
11
Type A aortic dissection secondary to a left common carotid artery dissection. ( 30937125 )
2019
12
Ocular ischaemia due to a spontaneous carotid artery dissection. ( 31061190 )
2019
13
Persistent isolated mydriasis as an early sign of internal carotid artery dissection: Pourfour du petit syndrome. ( 31082621 )
2019
14
A rare case of life-threatening traumatic carotid artery dissection in a child. ( 29740736 )
2019
15
Compliant balloon angioplasty for the treatment of internal carotid artery dissection. ( 30165775 )
2019
16
Endovascular repair of an acute symptomatic carotid artery dissection through the false dissecting carotid lumen. ( 30189757 )
2019
17
Migrainous Headache Accompanied by Hemi-Atrophy of the Tongue in Carotid Artery Dissection. ( 30221754 )
2019
18
Artery of Percheron territory infarct due to bilateral carotid artery dissection: when anterior circulation supplies the posterior one. ( 30225579 )
2019
19
Mild Traumatic Brain Injury Associated with Internal Carotid Artery Dissection and Pseudoaneurysm. ( 29937650 )
2018
20
Hypoglossal Nerve Palsy Due to Internal Carotid Artery Dissection. ( 30245772 )
2018
21
Unusual case of traumatic carotid artery dissection occurred during a work-related activity. A case report. ( 30378589 )
2018
22
Horner Syndrome Due to Spontaneous Internal Carotid Artery Dissection. ( 30519521 )
2018
23
Hemicrania continua in carotid artery dissection - symptomatic cases or linked pathophysiology? ( 28056533 )
2018
24
Pulsatile tinnitus and carotid artery dissection. ( 28126274 )
2018
25
Anatomical characteristics of the styloid process in internal carotid artery dissection: Case-control study. ( 28906206 )
2018
26
Internal carotid artery dissection among younger and older patients with acute ischemic stroke. ( 28920508 )
2018
27
Contrast-enhanced transoral carotid ultrasonography for the diagnosis and follow-up of extracranial internal carotid artery dissection: A case report. ( 28990690 )
2018
28
Recurrent cerebral infarction in anterior and posterior circulation territories associated with persistent primitive hypoglossal artery and carotid artery dissection: a case report. ( 29166846 )
2018
29
Distal internal carotid artery dissection after consumption of synthetic cannabinoid "Bonzai". ( 29274791 )
2018
30
Multiple cranial neuropathies as a presentation of spontaneous internal carotid artery dissection: A case report and literature review. ( 29422362 )
2018
31
Focal facial hyperhidrosis associated with internal carotid artery dissection successfully treated with botulinum toxin A. ( 29430719 )
2018
32
A 57-year-old man with a spontaneous carotid artery dissection. ( 29490326 )
2018
33
Internal Carotid Artery Dissection with Lidocaine Nerve Block Injection Trauma: A Rare Case Report. ( 29531880 )
2018
34
Unilateral lower cranial nerve palsies as the sole manifestation of internal carotid artery dissection: Case report. ( 29675876 )
2018
35
Multicentric Experience in Distal-to-Proximal Revascularization of Tandem Occlusion Stroke Related to Internal Carotid Artery Dissection. ( 29700047 )
2018
36
Common Carotid Artery Dissection in Multiple Extracranial Injury: A Case Report. ( 29774196 )
2018
37
A Collet-Sicard syndrome due to internal carotid artery dissection associated with cerebral amyloid angiopathy-related inflammation. ( 29844914 )
2018
38
Traumatic Penetrating Neck Injury with Right Common Carotid Artery Dissection and Stenosis Effectively Managed with Stenting: A Case Report and Review of the Literature. ( 29984035 )
2018
39
Internal carotid artery dissection without intracranial infarct following a minor shoulder trauma: The second pediatric case and review of the literature. ( 30041901 )
2018
40
Hypoglossal nerve palsy as an isolated syndrome of internal carotid artery dissection: A review of the literature and a case report. ( 30082078 )
2018
41
Resolution of Carotid Artery Dissection Confirmed by DANTE-SPACE MRI Sequence. ( 30213280 )
2018
42
Carotid Artery Dissection Following Neck Cannulation for Extracorporeal Life Support. ( 27143718 )
2017
43
Transcranial Doppler as a Predictor of Ischemic Events in Carotid Artery Dissection. ( 27491878 )
2017
44
Internal carotid artery dissection coincides with celiac artery dissection. ( 27495121 )
2017
45
Carotid Artery Dissection With Associated Territory Stroke After a Minor Head Trauma in a Healthy 4-Month-Old Child. ( 27668916 )
2017
46
Ischemic stroke due to internal carotid artery dissection associated with an elongated styloid process (Eagle syndrome). ( 27817853 )
2017
47
Maxillary tooth pain as a symptom of internal carotid artery dissection: Case series. ( 27916199 )
2017
48
Carotid artery dissection associated with long styloid process. ( 27940921 )
2017
49
Re. "Fate of the Distal False Aneurysms Complicating Internal Carotid Artery Dissection: Systematic Review". ( 27993455 )
2017
50
Carotid artery dissection secondary to carotid artery trauma caused by giant C1 transverse process. ( 28089538 )
2017
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Variations for Carotid Artery Dissection

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ClinVar genetic disease variations for Carotid Artery Dissection:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 LDLR NM_000527.4(LDLR): c.682G> A (p.Glu228Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121908029 GRCh37 Chromosome 19, 11216264: 11216264
2 LDLR NM_000527.4(LDLR): c.682G> A (p.Glu228Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121908029 GRCh38 Chromosome 19, 11105588: 11105588
3 MYLK NM_053025.3(MYLK): c.2149G> A (p.Asp717Asn) single nucleotide variant Uncertain significance rs150936840 GRCh38 Chromosome 3, 123707995: 123707995
4 MYLK NM_053025.3(MYLK): c.2149G> A (p.Asp717Asn) single nucleotide variant Uncertain significance rs150936840 GRCh37 Chromosome 3, 123426842: 123426842
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Expression for Carotid Artery Dissection

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Search GEO for disease gene expression data for Carotid Artery Dissection.
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Pathways for Carotid Artery Dissection

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Pathways related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development VEGF signaling via VEGFR2 - generic cascades 23
Show member pathways
 11.34 GAA GPC3
2
Metabolism of fat-soluble vitamins 67
Show member pathways
 10.95 GPC3 LDLR
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GO Terms for Carotid Artery Dissection

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Cellular components related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal lumen GO:0043202 8.96 GAA GPC3
2 lysosome GO:0005764 8.8 GAA GPC3 LDLR

Biological processes related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of endocytosis GO:0045807 8.32 GPC3
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Sources for Carotid Artery Dissection

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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