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MCID: CRT008
MIFTS: 44

Carotid Artery Dissection

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Carotid Artery Dissection

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MalaCards integrated aliases for Carotid Artery Dissection:

Name: Carotid Artery Dissection 12 76 15 73
Dissection of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9348
ICD10 33 I77.71
ICD9CM 35 443.21
SNOMED-CT 68 230729006
UMLS 73 C0338585
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Summaries for Carotid Artery Dissection

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MalaCards based summary : Carotid Artery Dissection, also known as dissection of carotid artery, is related to central retinal artery occlusion and ligneous conjunctivitis. An important gene associated with Carotid Artery Dissection is GPC3 (Glypican 3), and among its related pathways/superpathways are Cell adhesion_Plasmin signaling and NOTCH1 regulation of human endothelial cell calcification. The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and tongue, and related phenotypes are homeostasis/metabolism and cellular

Wikipedia : 76 Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing... more...

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Related Diseases for Carotid Artery Dissection

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Diseases related to Carotid Artery Dissection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 30.7 PLAT PLG
2 ligneous conjunctivitis 10.6 PLAT PLG
3 blue toe syndrome 10.6 ARG1 PLG
4 inferior myocardial infarction 10.5 PLAT PLG
5 brain compression 10.5 AVP PLAT
6 cerebritis 10.5
7 lemierre's syndrome 10.5 HOTAIR MTHFR PLG
8 intracranial embolism 10.5 PLAT PLG
9 cervicitis 10.4
10 acute anterolateral myocardial infarction 10.4 KANTR PLG
11 facial neuralgia 10.4 KANTR PLG
12 cerebral falx meningioma 10.4 KANTR PLG
13 headache 10.4
14 blood coagulation disease 10.4 ADAMTS13 MTHFR PLG
15 intracranial vasospasm 10.4 KANTR PLAT
16 cerebral arteritis 10.4 KANTR PLG
17 leech infestation 10.3 KANTR PLG
18 apical myocardial infarction 10.3 KANTR PLG
19 familial cervical artery dissection 10.3
20 antiphospholipid syndrome 10.3 ADAMTS13 MTHFR PLAT
21 vein disease 10.3 MTHFR PLAT PLG
22 thrombophilia due to activated protein c resistance 10.3 MTHFR PLAT PLG
23 horner's syndrome 10.3
24 hellp syndrome 10.3 ADAMTS13 MTHFR PLAT
25 aneurysm 10.3
26 inherited metabolic disorder 10.3 GAA MTHFR SERPINA1
27 oculomotor nerve paralysis 10.2 AVP KANTR
28 stroke, ischemic 10.2
29 third cranial nerve disease 10.2 AVP KANTR
30 brown-sequard syndrome 10.2 KANTR PLG ZNF451
31 cranial nerve palsy 10.2
32 posterolateral myocardial infarction 10.2 KANTR PKDREJ PLG
33 cerebrovascular disease 10.2 HOTAIR MTHFR PLAT
34 geniculate herpes zoster 10.2 KANTR SERPINA1
35 dirofilariasis 10.2 PLAT PLG RET
36 cluster headache 10.1
37 dental abscess 10.1 AVP KANTR
38 radial neuropathy 10.1 NOTCH1 SERPINA1
39 sphenoid sinusitis 10.1 AVP KANTR
40 alveolar periostitis 10.1 KANTR PLG
41 fibromuscular dysplasia 10.0
42 cerebral artery occlusion 10.0
43 retinitis 10.0
44 retinal artery occlusion 10.0
45 neuropathy 10.0
46 eagle syndrome 10.0
47 substernal goiter 10.0 KANTR NOTCH1
48 anterior cranial fossa meningioma 10.0 KANTR PLG
49 speech and communication disorders 10.0 KANTR PLAT PLG
50 takayasu arteritis 10.0

Graphical network of the top 20 diseases related to Carotid Artery Dissection:



Diseases related to Carotid Artery Dissection
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Symptoms & Phenotypes for Carotid Artery Dissection

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MGI Mouse Phenotypes related to Carotid Artery Dissection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 TGFBR2 ADAMTS13 NOTCH1 ARG1 AVP BDNF
2 cellular MP:0005384 10.1 RET TGFBR2 NOTCH1 BDNF PLAT DFFA
3 mortality/aging MP:0010768 9.93 TGFBR2 RET MTHFR ADAMTS13 ARG1 NOTCH1
4 digestive/alimentary MP:0005381 9.91 TGFBR2 RET NOTCH1 BDNF PLAT PLG
5 integument MP:0010771 9.86 ZNF451 NOTCH1 BDNF PLAT PLG GPC3
6 nervous system MP:0003631 9.65 RET TGFBR2 MTHFR ARG1 NOTCH1 AVP
7 respiratory system MP:0005388 9.17 TGFBR2 RET NOTCH1 BDNF PLAT PLG
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Drugs & Therapeutics for Carotid Artery Dissection

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Drugs for Carotid Artery Dissection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 3 55142-85-3 5472
2
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
3
Warfarin Approved Phase 3 81-81-2 6691 54678486
4
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
5
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
6
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
7
Dipyridamole Approved Phase 3 58-32-2 3108
8
Dalteparin Approved Phase 3 9005-49-6
9
Enoxaparin Approved Phase 3 9005-49-6 772
10 calcium heparin Phase 3
11 Analgesics Phase 3
12 Fibrinolytic Agents Phase 3
13 Coagulants Phase 3
14 Neurotransmitter Agents Phase 3
15 Cyclooxygenase Inhibitors Phase 3
16 Analgesics, Non-Narcotic Phase 3
17 Heparin, Low-Molecular-Weight Phase 3
18 Cytochrome P-450 Enzyme Inhibitors Phase 3
19 Vasodilator Agents Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Phosphodiesterase Inhibitors Phase 3
22 Platelet Aggregation Inhibitors Phase 3
23 Anticoagulants Phase 3
24 Anti-Inflammatory Agents Phase 3
25 Antipyretics Phase 3
26 Purinergic P2 Receptor Antagonists Phase 3
27 Anti-Inflammatory Agents, Non-Steroidal Phase 3
28 Purinergic P2Y Receptor Antagonists Phase 3
29 Antirheumatic Agents Phase 3
30 Calcium, Dietary Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection Completed NCT00238667 Phase 3 Antiplatelet (Aspirin, Dipyridamole, clopidogrel);Anticoagulant (Unfractionated Heparin, LMW Heparin, Warfarin)
2 Pupillometry in Horner's Syndrome Recruiting NCT02978079 Not Applicable

Search NIH Clinical Center for Carotid Artery Dissection

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Genetic Tests for Carotid Artery Dissection

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Anatomical Context for Carotid Artery Dissection

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MalaCards organs/tissues related to Carotid Artery Dissection:

41
Brain, Testes, Tongue, Kidney, Pituitary, Bone, Liver
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Publications for Carotid Artery Dissection

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Articles related to Carotid Artery Dissection:

(show top 50) (show all 583)
# Title Authors Year
1
Multiple cranial neuropathies as a presentation of spontaneous internal carotid artery dissection: A case report and literature review. ( 29422362 )
2018
2
Multicentric Experience in Distal-to-Proximal Revascularization of Tandem Occlusion Stroke Related to Internal Carotid Artery Dissection. ( 29700047 )
2018
3
Internal Carotid Artery Dissection with Lidocaine Nerve Block Injection Trauma: A Rare Case Report. ( 29531880 )
2018
4
A 57-year-old man with a spontaneous carotid artery dissection. ( 29490326 )
2018
5
Unilateral lower cranial nerve palsies as the sole manifestation of internal carotid artery dissection: Case report. ( 29675876 )
2018
6
A Collet-Sicard syndrome due to internal carotid artery dissection associated with cerebral amyloid angiopathy-related inflammation. ( 29844914 )
2018
7
A rare case of life-threatening traumatic carotid artery dissection in a child. ( 29740736 )
2018
8
Mild Traumatic Brain Injury Associated with Internal Carotid Artery Dissection and Pseudoaneurysm. ( 29937650 )
2018
9
Focal facial hyperhidrosis associated with internal carotid artery dissection successfully treated with botulinum toxin A. ( 29430719 )
2018
10
Common Carotid Artery Dissection in Multiple Extracranial Injury: A Case Report. ( 29774196 )
2018
11
Ruptured Vertebral Artery Dissecting Aneurysm Concurrent with Spontaneous Cervical Internal Carotid Artery Dissection: A Report of Three Cases and Literature Review. ( 28803173 )
2017
12
Isolated hypoglossal nerve palsy due to internal carotid artery dissection. ( 28320781 )
2017
13
Recurrent Cerebral Infarction in Anterior and Posterior Circulation Territories Associated with Persistent Primitive Hypoglossal Artery and Carotid Artery Dissection: A Case Report. ( 29166846 )
2017
14
Spontaneous carotid artery dissection. ( 28953020 )
2017
15
Internal carotid artery dissection and pseudoaneurysm formation with resultant ipsilateral hypoglossal nerve palsy. ( 28491191 )
2017
16
Internal Carotid Artery Dissection After Indirect Blunt Cervical Trauma in an Ice Hockey Goaltender. ( 28666040 )
2017
17
Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related? ( 28264078 )
2017
18
Bilateral carotid artery dissection. ( 28181757 )
2017
19
Retriever wire supported carotid artery revascularization (ReWiSed CARe) in acute ischemic stroke with underlying tandem occlusion caused by an internal carotid artery dissection: Technical note. ( 28162027 )
2017
20
Ischemic stroke due to internal carotid artery dissection associated with an elongated styloid process (Eagle syndrome). ( 27817853 )
2017
21
Beware the middle-aged migraine: internal carotid artery dissection mimicking migraine in the emergency department. ( 29184007 )
2017
22
Hemicrania continua in carotid artery dissection - symptomatic cases or linked pathophysiology? ( 28056533 )
2017
23
Extracranial internal carotid artery dissection caused by compression from a giant osteophyte due to atlantoaxial osteoarthritis: case report. ( 28498070 )
2017
24
Distal internal carotid artery dissection after consumption of synthetic cannabinoid "Bonzai". ( 29274791 )
2017
25
Contrast-enhanced transoral carotid ultrasonography for the diagnosis and follow-up of extracranial internal carotid artery dissection: A case report. ( 28990690 )
2017
26
Carotid artery dissection: a rare complication of Eagle syndrome. ( 28288997 )
2017
27
Complete ophthalmoplegia, complete ptosis and dilated pupil due to internal carotid artery dissection: as the first manifestation of Takayasu arteritis. ( 28743241 )
2017
28
Internal Carotid Artery Dissection in Brazilian Jiu-Jitsu. ( 29152471 )
2017
29
Carotid artery dissection secondary to carotid artery trauma caused by giant C1 transverse process. ( 28089538 )
2017
30
Spontaneous Recanalization After Carotid Artery Dissection: The Case for an Ultrasound-Only Monitoring Strategy. ( 29744017 )
2017
31
Eagle syndrome: A case report of stylocarotid syndrome with internal carotid artery dissection. ( 28530160 )
2017
32
Delayed recognition of Horner syndrome secondary to internal carotid artery dissection after scuba diving. ( 28186387 )
2017
33
Endovascular treatment in patients with carotid artery dissection and intracranial occlusion: a systematic review. ( 28580530 )
2017
34
Early endovascular stenting for extracranial carotid artery dissection with angiographic flow stasis: A series of four cases. ( 28864327 )
2017
35
Anatomical characteristics of the styloid process in internal carotid artery dissection: Case-control study. ( 28906206 )
2017
36
"Phacing" a New Cause of Carotid Artery Dissection. ( 28248915 )
2017
37
Internal carotid artery dissection and Villeret's syndrome. ( 29025003 )
2017
38
Internal carotid artery dissection among younger and older patients with acute ischemic stroke. ( 28920508 )
2017
39
Percutaneous Cervical Sympathetic Block for Pain Control after Internal Carotid Artery Dissection. A Report of Two Cases. ( 28243349 )
2017
40
Malignant Middle Cerebral Artery Infarction Secondary to Traumatic Bilateral Internal Carotid Artery Dissection. A Case Report. ( 29967852 )
2016
41
Intracranial internal carotid artery dissection following waterslide use: the first case report. ( 26815697 )
2016
42
Emergency endovascular revascularization of tandem occlusions: Internal carotid artery dissection and intracranial large artery embolism. ( 26924182 )
2016
43
Bilateral spontaneous internal carotid artery dissection managed with endovascular stenting - A case report. ( 27751333 )
2016
44
Endovascular reconstruction of internal carotid artery dissection in patients with acute ischemic stroke using the Wingspan stent. ( 27738098 )
2016
45
Common carotid artery dissection caused by radiotherapy: A case report. ( 27699045 )
2016
46
Horner's Syndrome due to a Spontaneous Internal Carotid Artery Dissection after Deep Sea Scuba Diving. ( 27525139 )
2016
47
Treatment of internal carotid artery dissection with Willis covered stent: A case report of recurrent limb weakness and no response to medical therapy. ( 27168838 )
2016
48
Carotid Artery Dissection and Ischemic Stroke After Severe Coughing. ( 27749665 )
2016
49
Internal carotid artery dissection. ( 27937023 )
2016
50
Mitochondrial m.3243AA >A G mutation and carotid artery dissection. ( 27656415 )
2016
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Variations for Carotid Artery Dissection

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Expression for Carotid Artery Dissection

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Search GEO for disease gene expression data for Carotid Artery Dissection.
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Pathways for Carotid Artery Dissection

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Pathways related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cell adhesion_Plasmin signaling 22
10.49 PLAT PLG TGFBR2
2
NOTCH1 regulation of human endothelial cell calcification 1
10.41 NOTCH1 PLAT
3
Dissolution of Fibrin Clot 66
10.07 PLAT PLG
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GO Terms for Carotid Artery Dissection

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Cellular components related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ADAMTS13 ARG1 AVP BDNF GPC3 NOTCH1
2 cell surface GO:0009986 9.55 ADAMTS13 NOTCH1 PLAT PLG TGFBR2
3 extracellular space GO:0005615 9.23 ADAMTS13 ARG1 AVP BDNF GPC3 PLAT

Biological processes related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.76 ARG1 MTHFR RET TGFBR2
2 fibrinolysis GO:0042730 9.48 PLAT PLG
3 blood coagulation GO:0007596 9.46 ADAMTS13 PLAT PLG SERPINA1
4 negative regulation of myotube differentiation GO:0010832 9.43 BDNF NOTCH1
5 negative regulation of cell-substrate adhesion GO:0010812 9.4 NOTCH1 PLG
6 response to amine GO:0014075 9.37 ADAMTS13 ARG1
7 atrioventricular valve morphogenesis GO:0003181 9.32 NOTCH1 TGFBR2
8 cardiac left ventricle morphogenesis GO:0003214 9.26 NOTCH1 TGFBR2
9 hemostasis GO:0007599 9.13 ADAMTS13 PLG SERPINA1
10 lung development GO:0030324 8.92 ARG1 GPC3 NOTCH1 TGFBR2
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Sources for Carotid Artery Dissection

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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