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MCID: CRT008
MIFTS: 45

Carotid Artery Dissection

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Carotid Artery Dissection

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MalaCards integrated aliases for Carotid Artery Dissection:

Name: Carotid Artery Dissection 12 76 15 73
Dissection of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9348
ICD10 33 I77.71
ICD9CM 35 443.21
NCIt 50 C125662
UMLS 73 C0338585
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Summaries for Carotid Artery Dissection

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MalaCards based summary : Carotid Artery Dissection, also known as dissection of carotid artery, is related to stroke, ischemic and central retinal artery occlusion. An important gene associated with Carotid Artery Dissection is GPC3 (Glypican 3), and among its related pathways/superpathways are Complement and coagulation cascades and Microglia Activation During Neuroinflammation: Overview. The drugs Clopidogrel and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and bone, and related phenotypes are Increased transferrin (TF) endocytosis and homeostasis/metabolism

Wikipedia : 76 Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing... more...

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Related Diseases for Carotid Artery Dissection

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Diseases related to Carotid Artery Dissection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 stroke, ischemic 30.4 ADAMTS13 MTHFR PLAT PLG
2 central retinal artery occlusion 30.3 PLAT PLG
3 thrombosis 29.7 ADAMTS13 MTHFR PLAT
4 headache 10.5
5 familial cervical artery dissection 10.5
6 horner's syndrome 10.4
7 cluster headache 10.2
8 fibromuscular dysplasia 10.2
9 blue toe syndrome 10.2 ARG1 PLG
10 eagle syndrome 10.2
11 catastrophic antiphospholipid syndrome 10.1 ADAMTS13 MTHFR
12 ligneous conjunctivitis 10.1 PLAT PLG
13 intracranial embolism 10.1 PLAT PLG
14 inferior myocardial infarction 10.1 PLAT PLG
15 lemierre's syndrome 10.1 HOTAIR MTHFR PLG
16 brain compression 10.1 AVP PLAT
17 cerebral artery occlusion 10.1
18 retinal artery occlusion 10.1
19 posterolateral myocardial infarction 10.1 KANTR PLG
20 acute anterolateral myocardial infarction 10.1 KANTR PLG
21 facial neuralgia 10.1 KANTR PLG
22 cerebral falx meningioma 10.1 KANTR PLG
23 cerebral arteritis 10.1 KANTR PLG
24 leech infestation 10.1 KANTR PLG
25 apical myocardial infarction 10.1 KANTR PLG
26 blood coagulation disease 10.1 ADAMTS13 MTHFR PLG
27 inherited metabolic disorder 10.1 GAA MTHFR SERPINA1
28 intracranial vasospasm 10.1 KANTR PLAT
29 oculomotor nerve paralysis 10.1 AVP KANTR
30 motion sickness 10.1 AVP ZNF451
31 third cranial nerve disease 10.1 AVP KANTR
32 alveolar periostitis 10.1 KANTR PLG
33 antiphospholipid syndrome 10.1 ADAMTS13 MTHFR PLAT
34 dental abscess 10.1 AVP KANTR
35 pulmonary artery disease 10.1 MTHFR PLAT PLG
36 geniculate herpes zoster 10.1 KANTR SERPINA1
37 takayasu arteritis 10.1
38 neuropathy 10.1
39 hemicrania continua 10.1
40 vein disease 10.1 MTHFR PLAT PLG
41 thrombophilia due to activated protein c resistance 10.1 MTHFR PLAT PLG
42 brown-sequard syndrome 10.1 KANTR PLG ZNF451
43 sphenoid sinusitis 10.1 AVP KANTR
44 cerebrovascular disease 10.0 HOTAIR MTHFR PLAT
45 anteroseptal myocardial infarction 10.0 KANTR PLG
46 posterior myocardial infarction 10.0 KANTR PLAT
47 anterior cranial fossa meningioma 10.0 KANTR PLG
48 subendocardial myocardial infarction 10.0 KANTR SERPINA1
49 marantic endocarditis 10.0 MTHFR PLAT
50 hemorrhagic disease 10.0 ADAMTS13 PLAT SERPINA1

Graphical network of the top 20 diseases related to Carotid Artery Dissection:



Diseases related to Carotid Artery Dissection
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Symptoms & Phenotypes for Carotid Artery Dissection

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GenomeRNAi Phenotypes related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.36 ACADS ADAMTS13 ARG1 AVP FBXW7 GAA

MGI Mouse Phenotypes related to Carotid Artery Dissection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 ACADS ADAMTS13 ARG1 AVP BDNF DFFA
2 cellular MP:0005384 10.13 ACADS BDNF DFFA FBXW7 GAA GPC3
3 mortality/aging MP:0010768 10.07 ACADS ADAMTS13 ARG1 AVP BDNF DAND5
4 digestive/alimentary MP:0005381 9.95 BDNF FBXW7 GPC3 PLAT PLG RET
5 integument MP:0010771 9.92 ACADS BDNF FBXW7 GPC3 MTHFR PLAT
6 nervous system MP:0003631 9.85 ARG1 AVP BDNF DFFA FBXW7 MTHFR
7 respiratory system MP:0005388 9.56 BDNF DAND5 FBXW7 GPC3 PLAT PLG
8 vision/eye MP:0005391 9.17 ADAMTS13 BDNF FBXW7 MTHFR PLAT PLG
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Drugs & Therapeutics for Carotid Artery Dissection

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Drugs for Carotid Artery Dissection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
2
Warfarin Approved Phase 3 81-81-2 6691 54678486
3
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
4
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
5
Enoxaparin Approved Phase 3 9005-49-6 772
6
Dipyridamole Approved Phase 3 58-32-2 3108
7
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
8
Ticlopidine Approved Phase 3 55142-85-3 5472
9
Dalteparin Approved Phase 3 9005-49-6
10 Analgesics Phase 3
11 Vasodilator Agents Phase 3
12 Purinergic P2Y Receptor Antagonists Phase 3
13 Antirheumatic Agents Phase 3
14 Heparin, Low-Molecular-Weight Phase 3
15 Calcium, Dietary Phase 3
16 Antipyretics Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Purinergic P2 Receptor Antagonists Phase 3
19 Platelet Aggregation Inhibitors Phase 3
20 Anti-Inflammatory Agents Phase 3
21 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
22 Anti-Inflammatory Agents, Non-Steroidal Phase 3
23 Fibrinolytic Agents Phase 3
24 Coagulants Phase 3
25 Neurotransmitter Agents Phase 3
26 calcium heparin Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 Anticoagulants Phase 3
29 Analgesics, Non-Narcotic Phase 3
30 Phosphodiesterase Inhibitors Phase 3
31 Cyclooxygenase Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection Completed NCT00238667 Phase 3 Antiplatelet (Aspirin, Dipyridamole, clopidogrel);Anticoagulant (Unfractionated Heparin, LMW Heparin, Warfarin)
2 Pupillometry in Horner's Syndrome Recruiting NCT02978079 Not Applicable

Search NIH Clinical Center for Carotid Artery Dissection

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Genetic Tests for Carotid Artery Dissection

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Anatomical Context for Carotid Artery Dissection

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MalaCards organs/tissues related to Carotid Artery Dissection:

41
Brain, Kidney, Bone, Pituitary, Liver, Skin, Heart
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Publications for Carotid Artery Dissection

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Articles related to Carotid Artery Dissection:

(show top 50) (show all 610)
# Title Authors Year
1
Internal carotid artery dissection causing pulsatile tinnitus. ( 30241776 )
2019
2
Multiple cranial neuropathies as a presentation of spontaneous internal carotid artery dissection: A case report and literature review. ( 29422362 )
2018
3
Multicentric Experience in Distal-to-Proximal Revascularization of Tandem Occlusion Stroke Related to Internal Carotid Artery Dissection. ( 29700047 )
2018
4
Internal Carotid Artery Dissection with Lidocaine Nerve Block Injection Trauma: A Rare Case Report. ( 29531880 )
2018
5
A 57-year-old man with a spontaneous carotid artery dissection. ( 29490326 )
2018
6
Unilateral lower cranial nerve palsies as the sole manifestation of internal carotid artery dissection: Case report. ( 29675876 )
2018
7
A Collet-Sicard syndrome due to internal carotid artery dissection associated with cerebral amyloid angiopathy-related inflammation. ( 29844914 )
2018
8
A rare case of life-threatening traumatic carotid artery dissection in a child. ( 29740736 )
2018
9
Mild Traumatic Brain Injury Associated with Internal Carotid Artery Dissection and Pseudoaneurysm. ( 29937650 )
2018
10
Focal facial hyperhidrosis associated with internal carotid artery dissection successfully treated with botulinum toxin A. ( 29430719 )
2018
11
Common Carotid Artery Dissection in Multiple Extracranial Injury: A Case Report. ( 29774196 )
2018
12
Pulsatile tinnitus and carotid artery dissection. ( 28126274 )
2018
13
Traumatic Penetrating Neck Injury with Right Common Carotid Artery Dissection and Stenosis Effectively Managed with Stenting: A Case Report and Review of the Literature. ( 29984035 )
2018
14
Internal carotid artery dissection without intracranial infarct following a minor shoulder trauma: The second pediatric case and review of the literature. ( 30041901 )
2018
15
Hypoglossal nerve palsy as an isolated syndrome of internal carotid artery dissection: A review of the literature and a case report. ( 30082078 )
2018
16
Compliant balloon angioplasty for the treatment of internal carotid artery dissection. ( 30165775 )
2018
17
Endovascular repair of an acute symptomatic carotid artery dissection through the false dissecting carotid lumen. ( 30189757 )
2018
18
Resolution of Carotid Artery Dissection Confirmed by DANTE-SPACE MRI Sequence. ( 30213280 )
2018
19
Migrainous Headache Accompanied by Hemi-Atrophy of the Tongue in Carotid Artery Dissection. ( 30221754 )
2018
20
Artery of Percheron territory infarct due to bilateral carotid artery dissection: when anterior circulation supplies the posterior one. ( 30225579 )
2018
21
Hypoglossal Nerve Palsy Due to Internal Carotid Artery Dissection. ( 30245772 )
2018
22
Global Orbital Infarction Syndrome After a Carotid Artery Dissection. ( 30285037 )
2018
23
Bilateral Vertebral Artery Dissection and Unilateral Carotid Artery Dissection in a Case of Ehlers-Danlos Syndrome Type IV. ( 30315974 )
2018
24
Unusual case of traumatic carotid artery dissection occurred during a work-related activity. A case report. ( 30378589 )
2018
25
Management of a pregnancy with underlying fibromuscular dysplasia with a history of stroke and carotid artery dissection. ( 30417729 )
2018
26
Horner Syndrome Due to Spontaneous Internal Carotid Artery Dissection. ( 30519521 )
2018
27
Ruptured Vertebral Artery Dissecting Aneurysm Concurrent with Spontaneous Cervical Internal Carotid Artery Dissection: A Report of Three Cases and Literature Review. ( 28803173 )
2017
28
Isolated hypoglossal nerve palsy due to internal carotid artery dissection. ( 28320781 )
2017
29
Recurrent Cerebral Infarction in Anterior and Posterior Circulation Territories Associated with Persistent Primitive Hypoglossal Artery and Carotid Artery Dissection: A Case Report. ( 29166846 )
2017
30
Spontaneous carotid artery dissection. ( 28953020 )
2017
31
Internal carotid artery dissection and pseudoaneurysm formation with resultant ipsilateral hypoglossal nerve palsy. ( 28491191 )
2017
32
Internal Carotid Artery Dissection After Indirect Blunt Cervical Trauma in an Ice Hockey Goaltender. ( 28666040 )
2017
33
Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related? ( 28264078 )
2017
34
Bilateral carotid artery dissection. ( 28181757 )
2017
35
Retriever wire supported carotid artery revascularization (ReWiSed CARe) in acute ischemic stroke with underlying tandem occlusion caused by an internal carotid artery dissection: Technical note. ( 28162027 )
2017
36
Ischemic stroke due to internal carotid artery dissection associated with an elongated styloid process (Eagle syndrome). ( 27817853 )
2017
37
Beware the middle-aged migraine: internal carotid artery dissection mimicking migraine in the emergency department. ( 29184007 )
2017
38
Hemicrania continua in carotid artery dissection - symptomatic cases or linked pathophysiology? ( 28056533 )
2017
39
Extracranial internal carotid artery dissection caused by compression from a giant osteophyte due to atlantoaxial osteoarthritis: case report. ( 28498070 )
2017
40
Distal internal carotid artery dissection after consumption of synthetic cannabinoid "Bonzai". ( 29274791 )
2017
41
Contrast-enhanced transoral carotid ultrasonography for the diagnosis and follow-up of extracranial internal carotid artery dissection: A case report. ( 28990690 )
2017
42
Carotid artery dissection: a rare complication of Eagle syndrome. ( 28288997 )
2017
43
Complete ophthalmoplegia, complete ptosis and dilated pupil due to internal carotid artery dissection: as the first manifestation of Takayasu arteritis. ( 28743241 )
2017
44
Internal Carotid Artery Dissection in Brazilian Jiu-Jitsu. ( 29152471 )
2017
45
Carotid artery dissection secondary to carotid artery trauma caused by giant C1 transverse process. ( 28089538 )
2017
46
Spontaneous Recanalization After Carotid Artery Dissection: The Case for an Ultrasound-Only Monitoring Strategy. ( 29744017 )
2017
47
Eagle syndrome: A case report of stylocarotid syndrome with internal carotid artery dissection. ( 28530160 )
2017
48
Delayed recognition of Horner syndrome secondary to internal carotid artery dissection after scuba diving. ( 28186387 )
2017
49
Endovascular treatment in patients with carotid artery dissection and intracranial occlusion: a systematic review. ( 28580530 )
2017
50
Early endovascular stenting for extracranial carotid artery dissection with angiographic flow stasis: A series of four cases. ( 28864327 )
2017
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Variations for Carotid Artery Dissection

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Expression for Carotid Artery Dissection

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Search GEO for disease gene expression data for Carotid Artery Dissection.
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Pathways for Carotid Artery Dissection

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Pathways related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Complement and coagulation cascades 1 37
11.64 PLAT PLG SERPINA1
2
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.43 GPC3 PLAT PLG
3
A-beta Pathways: Plaque Formation and APP Metabolism 65
10.62 PLAT PLG
4
Cell adhesion_Plasmin signaling 22
10.49 PLAT PLG TGFBR2
5
Dissolution of Fibrin Clot 66
10.07 PLAT PLG
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GO Terms for Carotid Artery Dissection

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Cellular components related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ADAMTS13 ARG1 AVP BDNF DAND5 GPC3
2 collagen-containing extracellular matrix GO:0062023 9.46 GPC3 PLAT PLG SERPINA1
3 extracellular space GO:0005615 9.28 ADAMTS13 ARG1 AVP BDNF DAND5 GPC3

Biological processes related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.67 ARG1 MTHFR RET TGFBR2
2 blood coagulation GO:0007596 9.46 ADAMTS13 PLAT PLG SERPINA1
3 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.43 DAND5 TGFBR2 ZNF451
4 fibrinolysis GO:0042730 9.4 PLAT PLG
5 response to amine GO:0014075 9.32 ADAMTS13 ARG1
6 hemostasis GO:0007599 9.13 ADAMTS13 PLG SERPINA1
7 lung development GO:0030324 8.92 ARG1 FBXW7 GPC3 TGFBR2
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Sources for Carotid Artery Dissection

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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