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MCID: CRT008
MIFTS: 37

Carotid Artery Dissection

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Carotid Artery Dissection

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MalaCards integrated aliases for Carotid Artery Dissection:

Name: Carotid Artery Dissection 12 77 6 15 74
Dissection of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9348
ICD9CM 36 443.21
NCIt 51 C125662
ICD10 34 I77.71
UMLS 74 C0338585
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Summaries for Carotid Artery Dissection

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MalaCards based summary : Carotid Artery Dissection, also known as dissection of carotid artery, is related to familial cervical artery dissection and headache. An important gene associated with Carotid Artery Dissection is LDLR (Low Density Lipoprotein Receptor), and among its related pathways/superpathways are Development VEGF signaling via VEGFR2 - generic cascades and Metabolism of fat-soluble vitamins. The drugs Aspirin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and tongue, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Wikipedia : 77 Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing... more...

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Related Diseases for Carotid Artery Dissection

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Diseases related to Carotid Artery Dissection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 familial cervical artery dissection 10.5
2 headache 10.5
3 horner's syndrome 10.4
4 stroke, ischemic 10.3
5 fibromuscular dysplasia 10.3
6 cluster headache 10.3
7 eagle syndrome 10.2
8 cerebral artery occlusion 10.1
9 retinal artery occlusion 10.1
10 takayasu arteritis 10.1
11 central retinal artery occlusion 10.1
12 neuropathy 10.1
13 hemicrania continua 10.1
14 systemic lupus erythematosus 10.0
15 middle cerebral artery infarction 10.0
16 polycystic kidney disease 10.0
17 intracranial aneurysm 10.0
18 pertussis 10.0
19 pituitary apoplexy 10.0
20 optic nerve disease 10.0
21 essential thrombocythemia 10.0
22 syphilis 10.0
23 kidney disease 10.0
24 lupus erythematosus 10.0
25 reversible cerebral vasoconstriction syndrome 10.0
26 whiplash 10.0
27 cerebral aneurysms 10.0
28 dysphagia 10.0
29 encephalopathy 10.0
30 cerebral amyloid angiopathy, cst3-related 9.8
31 intussusception 9.8
32 macroglossia 9.8
33 marfan syndrome 9.8
34 polycystic liver disease 1 with or without kidney cysts 9.8
35 moyamoya disease 1 9.8
36 brittle bone disorder 9.8
37 alpha-1-antitrypsin deficiency 9.8
38 brain injury 9.8
39 ischemic optic neuropathy 9.8
40 liver disease 9.8
41 osteoarthritis 9.8
42 traumatic brain injury 9.8
43 polycystic liver disease 9.8
44 withdrawal disorder 9.8
45 ptosis 9.8
46 thrombosis 9.8
47 thrombotic thrombocytopenic purpura 9.8
48 anhidrosis 9.8
49 vertebral artery occlusion 9.8
50 tolosa-hunt syndrome 9.8

Graphical network of the top 20 diseases related to Carotid Artery Dissection:



Diseases related to Carotid Artery Dissection
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Symptoms & Phenotypes for Carotid Artery Dissection

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GenomeRNAi Phenotypes related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.8 ACADS GAA LDLR

MGI Mouse Phenotypes related to Carotid Artery Dissection:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 8.92 DAND5 GAA GPC3 LDLR
Sources

Drugs & Therapeutics for Carotid Artery Dissection

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Drugs for Carotid Artery Dissection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
2
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
3
Dipyridamole Approved Phase 3 58-32-2 3108
4
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
5
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
6
Dalteparin Approved Phase 3 9005-49-6
7
Enoxaparin Approved Phase 3 9005-49-6 772
8
Warfarin Approved Phase 3 81-81-2 6691 54678486
9
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
10 Vasodilator Agents Phase 3
11 calcium heparin Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Anti-Inflammatory Agents Phase 3
14 Coagulants Phase 3
15 Fibrinolytic Agents Phase 3
16 Cyclooxygenase Inhibitors Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antipyretics Phase 3
19 Neurotransmitter Agents Phase 3
20 Heparin, Low-Molecular-Weight Phase 3
21 Purinergic P2 Receptor Antagonists Phase 3
22 Anticoagulants Phase 3
23 Analgesics Phase 3
24 Calcium, Dietary Phase 3
25 Platelet Aggregation Inhibitors Phase 3
26 Purinergic P2Y Receptor Antagonists Phase 3
27 Phosphodiesterase Inhibitors Phase 3
28 Antirheumatic Agents Phase 3
29 Analgesics, Non-Narcotic Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection Completed NCT00238667 Phase 3 Antiplatelet (Aspirin, Dipyridamole, clopidogrel);Anticoagulant (Unfractionated Heparin, LMW Heparin, Warfarin)
2 Pupillometry in Horner's Syndrome Recruiting NCT02978079 Not Applicable

Search NIH Clinical Center for Carotid Artery Dissection

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Genetic Tests for Carotid Artery Dissection

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Anatomical Context for Carotid Artery Dissection

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MalaCards organs/tissues related to Carotid Artery Dissection:

42
Brain, Testes, Tongue, Kidney, Bone, Pituitary, Liver
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Publications for Carotid Artery Dissection

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Articles related to Carotid Artery Dissection:

(show top 50) (show all 617)
# Title Authors Year
1
Internal carotid artery dissection causing pulsatile tinnitus. ( 30241776 )
2019
2
Bilateral Vertebral Artery Dissection and Unilateral Carotid Artery Dissection in Case of Ehlers-Danlos Syndrome Type IV. ( 30315974 )
2019
3
Unusual case of traumatic cervical internal carotid artery dissection presenting as pseudofenestration. ( 30612106 )
2019
4
A Case of Bilateral Extracranial Internal Carotid Artery Dissection Due to the Helmet Strap After Motorcycle Crash. ( 30624242 )
2019
5
False Aneurysms Complicating Internal Carotid Artery Dissection. ( 30630394 )
2019
6
Hypoglossal nerve palsy due to carotid artery dissection: an uncommon presentation of a common problem. ( 30648931 )
2019
7
Surgical treatment of spontaneous internal carotid artery dissection with abducent nerve palsy: A case report and review of literature. ( 30711658 )
2019
8
Internal carotid artery dissection causing ischemic stroke during pole sport practice. ( 30758162 )
2019
9
Multiple cranial neuropathies as a presentation of spontaneous internal carotid artery dissection: A case report and literature review. ( 29422362 )
2018
10
Multicentric Experience in Distal-to-Proximal Revascularization of Tandem Occlusion Stroke Related to Internal Carotid Artery Dissection. ( 29700047 )
2018
11
Internal Carotid Artery Dissection with Lidocaine Nerve Block Injection Trauma: A Rare Case Report. ( 29531880 )
2018
12
A 57-year-old man with a spontaneous carotid artery dissection. ( 29490326 )
2018
13
Unilateral lower cranial nerve palsies as the sole manifestation of internal carotid artery dissection: Case report. ( 29675876 )
2018
14
A Collet-Sicard syndrome due to internal carotid artery dissection associated with cerebral amyloid angiopathy-related inflammation. ( 29844914 )
2018
15
A rare case of life-threatening traumatic carotid artery dissection in a child. ( 29740736 )
2018
16
Mild Traumatic Brain Injury Associated with Internal Carotid Artery Dissection and Pseudoaneurysm. ( 29937650 )
2018
17
Focal facial hyperhidrosis associated with internal carotid artery dissection successfully treated with botulinum toxin A. ( 29430719 )
2018
18
Common Carotid Artery Dissection in Multiple Extracranial Injury: A Case Report. ( 29774196 )
2018
19
Pulsatile tinnitus and carotid artery dissection. ( 28126274 )
2018
20
Traumatic Penetrating Neck Injury with Right Common Carotid Artery Dissection and Stenosis Effectively Managed with Stenting: A Case Report and Review of the Literature. ( 29984035 )
2018
21
Internal carotid artery dissection without intracranial infarct following a minor shoulder trauma: The second pediatric case and review of the literature. ( 30041901 )
2018
22
Hypoglossal nerve palsy as an isolated syndrome of internal carotid artery dissection: A review of the literature and a case report. ( 30082078 )
2018
23
Compliant balloon angioplasty for the treatment of internal carotid artery dissection. ( 30165775 )
2018
24
Endovascular repair of an acute symptomatic carotid artery dissection through the false dissecting carotid lumen. ( 30189757 )
2018
25
Resolution of Carotid Artery Dissection Confirmed by DANTE-SPACE MRI Sequence. ( 30213280 )
2018
26
Migrainous Headache Accompanied by Hemi-Atrophy of the Tongue in Carotid Artery Dissection. ( 30221754 )
2018
27
Artery of Percheron territory infarct due to bilateral carotid artery dissection: when anterior circulation supplies the posterior one. ( 30225579 )
2018
28
Hypoglossal Nerve Palsy Due to Internal Carotid Artery Dissection. ( 30245772 )
2018
29
Global Orbital Infarction Syndrome After a Carotid Artery Dissection. ( 30285037 )
2018
30
Unusual case of traumatic carotid artery dissection occurred during a work-related activity. A case report. ( 30378589 )
2018
31
Management of a pregnancy with underlying fibromuscular dysplasia with a history of stroke and carotid artery dissection. ( 30417729 )
2018
32
Horner Syndrome Due to Spontaneous Internal Carotid Artery Dissection. ( 30519521 )
2018
33
Ruptured Vertebral Artery Dissecting Aneurysm Concurrent with Spontaneous Cervical Internal Carotid Artery Dissection: A Report of Three Cases and Literature Review. ( 28803173 )
2017
34
Isolated hypoglossal nerve palsy due to internal carotid artery dissection. ( 28320781 )
2017
35
Recurrent Cerebral Infarction in Anterior and Posterior Circulation Territories Associated with Persistent Primitive Hypoglossal Artery and Carotid Artery Dissection: A Case Report. ( 29166846 )
2017
36
Spontaneous carotid artery dissection. ( 28953020 )
2017
37
Internal carotid artery dissection and pseudoaneurysm formation with resultant ipsilateral hypoglossal nerve palsy. ( 28491191 )
2017
38
Internal Carotid Artery Dissection After Indirect Blunt Cervical Trauma in an Ice Hockey Goaltender. ( 28666040 )
2017
39
Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related? ( 28264078 )
2017
40
Bilateral carotid artery dissection. ( 28181757 )
2017
41
Retriever wire supported carotid artery revascularization (ReWiSed CARe) in acute ischemic stroke with underlying tandem occlusion caused by an internal carotid artery dissection: Technical note. ( 28162027 )
2017
42
Ischemic stroke due to internal carotid artery dissection associated with an elongated styloid process (Eagle syndrome). ( 27817853 )
2017
43
Beware the middle-aged migraine: internal carotid artery dissection mimicking migraine in the emergency department. ( 29184007 )
2017
44
Hemicrania continua in carotid artery dissection - symptomatic cases or linked pathophysiology? ( 28056533 )
2017
45
Extracranial internal carotid artery dissection caused by compression from a giant osteophyte due to atlantoaxial osteoarthritis: case report. ( 28498070 )
2017
46
Distal internal carotid artery dissection after consumption of synthetic cannabinoid "Bonzai". ( 29274791 )
2017
47
Contrast-enhanced transoral carotid ultrasonography for the diagnosis and follow-up of extracranial internal carotid artery dissection: A case report. ( 28990690 )
2017
48
Carotid artery dissection: a rare complication of Eagle syndrome. ( 28288997 )
2017
49
Complete ophthalmoplegia, complete ptosis and dilated pupil due to internal carotid artery dissection: as the first manifestation of Takayasu arteritis. ( 28743241 )
2017
50
Internal Carotid Artery Dissection in Brazilian Jiu-Jitsu. ( 29152471 )
2017
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Variations for Carotid Artery Dissection

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ClinVar genetic disease variations for Carotid Artery Dissection:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 LDLR NM_000527.4(LDLR): c.682G> A (p.Glu228Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121908029 GRCh37 Chromosome 19, 11216264: 11216264
2 LDLR NM_000527.4(LDLR): c.682G> A (p.Glu228Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121908029 GRCh38 Chromosome 19, 11105588: 11105588
3 MYLK NM_053025.3(MYLK): c.2149G> A (p.Asp717Asn) single nucleotide variant Uncertain significance rs150936840 GRCh38 Chromosome 3, 123707995: 123707995
4 MYLK NM_053025.3(MYLK): c.2149G> A (p.Asp717Asn) single nucleotide variant Uncertain significance rs150936840 GRCh37 Chromosome 3, 123426842: 123426842
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Expression for Carotid Artery Dissection

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Search GEO for disease gene expression data for Carotid Artery Dissection.
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Pathways for Carotid Artery Dissection

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Pathways related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development VEGF signaling via VEGFR2 - generic cascades 23
Show member pathways
 11.34 GAA GPC3
2
Metabolism of fat-soluble vitamins 67
Show member pathways
 10.95 GPC3 LDLR
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GO Terms for Carotid Artery Dissection

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Cellular components related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal lumen GO:0043202 8.96 GAA GPC3
2 lysosome GO:0005764 8.8 GAA GPC3 LDLR

Biological processes related to Carotid Artery Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of endocytosis GO:0045807 8.32 GPC3
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Sources for Carotid Artery Dissection

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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