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MCID: CRT015
MIFTS: 44

Carotid Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Carotid Artery Occlusion

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MalaCards integrated aliases for Carotid Artery Occlusion:

Name: Carotid Artery Occlusion 12 15 73
Occlusion and Stenosis of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:807
ICD9CM 35 433.10
ICD10 33 I65.2
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Summaries for Carotid Artery Occlusion

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MalaCards based summary : Carotid Artery Occlusion, also known as occlusion and stenosis of carotid artery, is related to ischemia and spinal cord infarction. An important gene associated with Carotid Artery Occlusion is HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Abciximab and Fibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are growth/size/body region and homeostasis/metabolism

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Related Diseases for Carotid Artery Occlusion

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Diseases related to Carotid Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.6 HSPA1A MAP2 NOS3
2 spinal cord infarction 30.6 APOH F5
3 thrombosis 30.5 APOH F5 THBD
4 transient cerebral ischemia 29.9 APOH HSPA1A MAP2
5 vascular disease 29.3 APOH F5 NOS3 THBD
6 thrombophilia due to thrombin defect 29.3 APOH F5 F8 THBD
7 stroke, ischemic 27.7 APOH F5 MAP2 MBP NOS3 THBD
8 moyamoya disease 1 11.5
9 cerebritis 10.7
10 acquired hemophilia a 10.7 F5 F8
11 acquired hemophilia 10.7 F5 F8
12 may-thurner syndrome 10.7 APOH F5
13 factor v and factor viii, combined deficiency of, 2 10.7 F5 F8
14 acanthamoeba keratitis 10.7 APOH F5
15 priapism 10.7 F5 NOS3
16 factor viii deficiency 10.7 F5 F8
17 livedoid vasculopathy 10.7 APOH F5
18 cerebral sinovenous thrombosis 10.7 APOH F5
19 pregnancy loss, recurrent 1 10.6 APOH F5
20 prothrombin deficiency, congenital 10.6 APOH F5
21 breast reconstruction 10.6 APOH F8
22 ischemic colitis 10.6 APOH F5
23 buerger disease 10.6 APOH NOS3
24 catastrophic antiphospholipid syndrome 10.6 APOH F5
25 sneddon syndrome 10.6 APOH F5
26 factor xiii deficiency 10.6 F5 F8
27 post-thrombotic syndrome 10.6 F5 F8
28 retinal vascular occlusion 10.6 APOH F5
29 arteritic anterior ischemic optic neuropathy 10.6 F5 NOS3
30 antithrombin iii deficiency 10.6 APOH F5
31 peripheral vertigo 10.6 APOH F5
32 central retinal vein occlusion 10.6 APOH F5
33 meningococcemia 10.6 F5 THBD
34 acute mountain sickness 10.5 HSPA1A NOS3
35 factor xii deficiency 10.5 APOH F5
36 hemophilia a 10.5 F5 F8
37 portal vein thrombosis 10.5 APOH F5
38 raynaud phenomenon 10.5 APOH THBD
39 legg-calve-perthes disease 10.5 F5 THBD
40 severe hemophilia a 10.5 F5 F8
41 aneurysm 10.5
42 protein s deficiency 10.5 APOH F5
43 vein disease 10.5 F5 F8
44 pericardium cancer 10.5 F8 THBD
45 dysfibrinogenemia 10.5 F5 THBD
46 cervicitis 10.4
47 hepatic veno-occlusive disease 10.4 F8 THBD
48 hepatic infarction 10.4 APOH CA4
49 intracranial hypertension 10.4 APOH F5
50 transverse myelitis 10.4 APOH MBP

Graphical network of the top 20 diseases related to Carotid Artery Occlusion:



Diseases related to Carotid Artery Occlusion
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Symptoms & Phenotypes for Carotid Artery Occlusion

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MGI Mouse Phenotypes related to Carotid Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 NOS3 THBD ADAMTS18 BCO1 CA4 F5
2 homeostasis/metabolism MP:0005376 9.61 THBD ADAMTS18 APOH BCO1 CA4 F5
3 reproductive system MP:0005389 9.17 THBD ADAMTS18 CA4 F8 MAP2 MBP
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Drugs & Therapeutics for Carotid Artery Occlusion

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Drugs for Carotid Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable
3 Tissue Plasminogen Activator Phase 4,Phase 1,Phase 2,Not Applicable
4 Plasminogen Phase 4,Phase 1,Phase 2,Not Applicable
5 Platelet Aggregation Inhibitors Phase 4,Phase 3
6 Antibodies Phase 4,Phase 3
7 Immunoglobulins Phase 4,Phase 3
8 Antibodies, Monoclonal Phase 4,Phase 3
9 Immunoglobulin Fab Fragments Phase 4
10 Anticoagulants Phase 4
11
Ticlopidine Approved Phase 3 55142-85-3 5472
12
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
13
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
14
Ezetimibe Approved Phase 3 163222-33-1 150311
15
Fenofibrate Approved Phase 3 49562-28-9 3339
16
Xylometazoline Approved, Investigational Phase 3 526-36-3 5709
17 Analgesics Phase 3,Phase 1,Phase 2
18 Neurotransmitter Agents Phase 3,Phase 1,Phase 2
19 Cyclooxygenase Inhibitors Phase 3
20 Analgesics, Non-Narcotic Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
23 Anti-Inflammatory Agents Phase 3
24 Antipyretics Phase 3
25 Purinergic P2 Receptor Antagonists Phase 3
26 Anti-Inflammatory Agents, Non-Steroidal Phase 3
27 Purinergic P2Y Receptor Antagonists Phase 3
28 Antirheumatic Agents Phase 3
29 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
30 Pharmaceutical Solutions Phase 3
31
Ketamine Approved, Vet_approved Phase 1, Phase 2 6740-88-1 3821
32 Central Nervous System Depressants Phase 1, Phase 2
33 Anesthetics Phase 1, Phase 2,Not Applicable
34 Anesthetics, Dissociative Phase 1, Phase 2
35 Anesthetics, General Phase 1, Phase 2
36 Anesthetics, Intravenous Phase 1, Phase 2
37 Excitatory Amino Acid Antagonists Phase 1, Phase 2
38 Excitatory Amino Acids Phase 1, Phase 2

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
2 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
3 Phase III Study To Evaluate Alirocumab in Patients With Hypercholesterolemia Not Treated With a Statin (ODYSSEY CHOICE II) Completed NCT02023879 Phase 3 Alirocumab;Placebo (for Alirocumab);Non-statin LMT
4 Carotid Occlusion Surgery Study Terminated NCT00029146 Phase 3 best medical therapy
5 Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting Terminated NCT00395785 Phase 2, Phase 3
6 Ketamine for Thrombolysis in Acute Ischemic Stroke Unknown status NCT02258204 Phase 1, Phase 2 Ketamine;Placebo
7 Prediction of Carotid Occlusion Intolerance by Transcranial Doppler Evaluation in Patients Undergoing Carotid Artery Stenting With Proximal Flow Arrest Protection System. Unknown status NCT01922609
8 Study of Carotid Occlusion and Neurocognition Completed NCT00390481 Not Applicable
9 Aneurysms and Carotid Artery Block in Newborns Completed NCT00646672
10 Postapproval Trial On Carotid Stenting in Patients With High Risk Vs Standard Risk for Open Carotid Endarterectomy(REAL) Completed NCT02750644
11 Endovascular Revascularization for Chronic Carotid Artery Occlusion Trial Recruiting NCT03179774 Not Applicable
12 Sensitivity to Acute Cerebral Ischemia in Migrainers Recruiting NCT03301441
13 STAMCAR: A Prospective EC-IC Bypass Registry Recruiting NCT02779803
14 Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A) Recruiting NCT02811536
15 CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHD™ Recruiting NCT03179800 Not Applicable
16 Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase Terminated NCT02216565 Not Applicable Alteplase if patient is eligible
17 Endovascular Revascularization of Symptomatic Chronically Occluded Internal Carotid Artery Withdrawn NCT03176420 Not Applicable

Search NIH Clinical Center for Carotid Artery Occlusion

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Genetic Tests for Carotid Artery Occlusion

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Anatomical Context for Carotid Artery Occlusion

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MalaCards organs/tissues related to Carotid Artery Occlusion:

41
Brain, Eye, Testes, Pituitary, Retina, Endothelial, Cortex
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Publications for Carotid Artery Occlusion

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Articles related to Carotid Artery Occlusion:

(show top 50) (show all 650)
# Title Authors Year
1
Management of Cavernous Sinus Meningioma Presenting With Cerebrovascular Insufficiency Secondary to Cavernous Carotid Artery Occlusion: Report of 2 Cases. ( 29850864 )
2018
2
Three-Year Clinical Results of Carotid Artery Stenting in Treating Patients with Contralateral Carotid Artery Occlusion. ( 29428329 )
2018
3
Potential of carnosine, a histamine precursor in rat model of bilateral common carotid artery occlusion-induced vascular dementia. ( 29676814 )
2018
4
Correction: Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). ( 29684064 )
2018
5
Cervical Internal Carotid Artery Occlusion versus Pseudo-Occlusion: Can CT Angiography Help Distinguish These in the Acute Stroke Setting? ( 29461944 )
2018
6
Coexistent Ipsilateral Internal Carotid Artery Occlusion and Cerebral Venous Thrombosis in Hepatitis C. ( 29349091 )
2018
7
Evaluation of revascularization after total arch replacement in common carotid artery occlusion. ( 29376064 )
2018
8
Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). ( 29547662 )
2018
9
Ring-stripping retrograde endarterectomy for treatment of common carotid artery occlusion: a minimally invasive, effective procedure. ( 29885429 )
2018
10
Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion. ( 29402275 )
2018
11
Simple aspiration with balloon catheter technique (simple ABC technique) against proximal internal carotid artery occlusion in cases of cardiogenic cerebral embolism. ( 29378450 )
2018
12
Circle of Willis Collateral Flow in Carotid Artery Occlusion Is Depicted by 4D-CTA. ( 29530689 )
2018
13
Gastrodin Attenuates Bilateral Common Carotid Artery Occlusion-Induced Cognitive Deficits via Regulating AI^-Related Proteins and Reducing Autophagy and Apoptosis in Rats. ( 29755351 )
2018
14
Poststroke epilepsy following transient unilateral middle cerebral and common carotid artery occlusion in young adult and aged F344 rats. ( 29455049 )
2018
15
Clinical Significance of the Circle of Willis in Patients with Symptomatic Internal Carotid Artery Occlusion. ( 29702309 )
2018
16
High-resolution magnetic resonance vessel wall imaging of chronic intracranial internal carotid artery occlusion. ( 29752977 )
2018
17
Disappearance of a ruptured posterior cerebral artery aneurysm associated with internal carotid artery occlusion after superficial temporal artery to middle cerebral artery bypass. ( 29803057 )
2018
18
Angioplasty and stenting for symptomatic extracranial non-tandem internal carotid artery occlusion. ( 29706606 )
2018
19
Impact of external carotid artery occlusion at declamping of the external and common carotid arteries during carotid endarterectomy on development of new postoperative ischemic cerebral lesions. ( 29960793 )
2018
20
Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. ( 29385102 )
2018
21
Alarming Results for Carotid Artery Stenting in Patients with Contralateral Carotid Artery Occlusion. ( 29729843 )
2018
22
Carotid Artery Occlusion Caused by the Judo Chokehold Technique, 'Shime-waza'. ( 28381762 )
2017
23
Internal carotid artery occlusion and stroke as a complication of cisplatin-based chemotherapy for metastatic testicular germ cell tumour. ( 28630245 )
2017
24
Cerebral Perfusion After Repair of Congenital Diaphragmatic Hernia with Common Carotid Artery Occlusion After ECMO Therapy. ( 28652420 )
2017
25
Pretemporal ("Half-and-Half") Approach for Posterior Circulation Aneurysms in a Patient With Internal Carotid Artery Occlusion. ( 28961943 )
2017
26
Trans-Anterior Communicating Artery Primary Stenting in Acute Tandem Middle Cerebral Artery-Internal Carotid Artery Occlusion Due to Thoracic Aortic Stent Graft. ( 28710049 )
2017
27
Internal Carotid Artery Occlusion in Systemic Lupus Erythematosus as a Potential Mimicker of Multiple Sclerosis. ( 28559831 )
2017
28
Collateral Assessment by CT Angiography as a Predictor of Outcome in Symptomatic Cervical Internal Carotid Artery Occlusion. ( 27765736 )
2017
29
Relay-balloon technique for recanalization of acute symptomatic proximal internal carotid artery occlusion with short balloon-tipped guiding catheter landing zone. ( 28108499 )
2017
30
Diagnostic accuracy of emergency CT angiography for presumed tandem internal carotid artery occlusion before acute endovascular therapy. ( 29101306 )
2017
31
Usefulness of contralateral carotid angiography in revascularization therapy of acute internal carotid artery occlusion. ( 28946180 )
2017
32
Rationale for graft selection in patients with complex internal carotid artery aneurysms treated with extracranial to intracranial high-flow bypass and therapeutic internal carotid artery occlusion. ( 28574313 )
2017
33
Carotid artery revascularization in patients with contralateral carotid artery occlusion: Stent or endarterectomy? ( 28666824 )
2017
34
Endovascular Revascularization of a Symptomatic Common Carotid Artery Occlusion. ( 28004633 )
2017
35
Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion. ( 29200907 )
2017
36
Posterior cerebral artery giant aneurysm associated with bilateral internal carotid artery occlusion in a Klippel-Trenaunay syndrome patient: a case report. ( 29069941 )
2017
37
Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion. ( 28103941 )
2017
38
Reply to Letter to the Editor "Concern on article "Predicting procedure successful rate and 1-year patency after endovascular recanalization for chronic carotid artery occlusion by CT angiography". ( 27884566 )
2017
39
Distinctive patterns on CT angiography characterize acute internal carotid artery occlusion subtypes. ( 28151850 )
2017
40
Evaluation of Neuroprotective Effect of Hibiscus sabdariffa Linn. Aqueous Extract Against Ischaemic-Reperfusion Insult by Bilateral Common Carotid Artery Occlusion in Adult Male Rats. ( 29134984 )
2017
41
Proximal flow to middle cerebral artery is associated with higher thrombus density in terminal internal carotid artery occlusion. ( 28695152 )
2017
42
Astrocyte activation and capillary remodeling in modified bilateral common carotid artery occlusion mice. ( 28261893 )
2017
43
Endovascular plug for internal carotid artery occlusion in the management of a cavernous pseudoaneurysm with bifrontal subdural empyema: technical note. ( 28621574 )
2017
44
Combined interventional and surgical treatment of tandem middle cerebral artery embolus and internal carotid artery occlusion: case report. ( 29148900 )
2017
45
Carotid artery occlusion in Kabuki syndrome: Case report and literature review. ( 28607822 )
2017
46
Collateral Flow and White Matter Disease in Patients with Internal Carotid Artery Occlusion. ( 27924799 )
2017
47
Internal Carotid Artery Occlusion: Pathophysiology, Diagnosis, and Management. ( 28861849 )
2017
48
Enterprise stent in recanalizing non-acute atherosclerotic intracranial internal carotid artery occlusion. ( 28926782 )
2017
49
Carotid-Carotid Artery Crossover Bypass with a Synthetic Vascular Graft for Symptomatic Type 1A Common Carotid Artery Occlusion. ( 29269063 )
2017
50
Concern on article "Predicting procedure successful rate and 1-year patency after endovascular recanalization for chronic carotid artery occlusion by CT angiography". ( 27919423 )
2017
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Variations for Carotid Artery Occlusion

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Expression for Carotid Artery Occlusion

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Search GEO for disease gene expression data for Carotid Artery Occlusion.
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Pathways for Carotid Artery Occlusion

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Pathways related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.84 APOH F5 F8 NOS3 THBD
2
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.33 F5 F8 THBD
3
Complement and coagulation cascades 1 37
10.94 F5 F8 THBD
4
O2/CO2 exchange in erythrocytes 66
Show member pathways
 10.87 CA1 CA4
5
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
10.79 NOS3 THBD
6
Nitrogen metabolism 37
Show member pathways
 10.62 CA1 CA4
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GO Terms for Carotid Artery Occlusion

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Cellular components related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 COPII-coated ER to Golgi transport vesicle GO:0030134 8.62 F5 F8

Biological processes related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.58 F5 F8 THBD
2 platelet degranulation GO:0002576 9.5 APOH F5 F8
3 bicarbonate transport GO:0015701 9.46 CA1 CA4
4 one-carbon metabolic process GO:0006730 9.43 CA1 CA4
5 blood coagulation, intrinsic pathway GO:0007597 9.37 APOH F8
6 negative regulation of blood coagulation GO:0030195 9.26 APOH THBD
7 negative regulation of fibrinolysis GO:0051918 9.16 APOH THBD
8 negative regulation of platelet activation GO:0010544 8.96 NOS3 THBD
9 hemostasis GO:0007599 8.8 F5 F8 THBD

Molecular functions related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.13 MAP2 MBP NOS3
2 carbonate dehydratase activity GO:0004089 8.62 CA1 CA4
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Sources for Carotid Artery Occlusion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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