MCID: CRT015
MIFTS: 45

Carotid Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Artery Occlusion

MalaCards integrated aliases for Carotid Artery Occlusion:

Name: Carotid Artery Occlusion 12 6 15 71
Occlusion and Stenosis of Carotid Artery 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:807
ICD9CM 34 433.10
ICD10 32 I65.2
UMLS 71 C0265101 C0375275

Summaries for Carotid Artery Occlusion

MalaCards based summary : Carotid Artery Occlusion, also known as occlusion and stenosis of carotid artery, is related to moyamoya disease 1 and carotid artery dissection. An important gene associated with Carotid Artery Occlusion is LDLR (Low Density Lipoprotein Receptor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Neuroscience. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and pituitary, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Carotid Artery Occlusion

Diseases related to Carotid Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 moyamoya disease 1 32.1 PLG PLAT MYLK
2 carotid artery dissection 31.0 MYLK LDLR
3 transient cerebral ischemia 30.8 MAP2 IL1B HSPA1A CASP3 APOH
4 cerebrovascular disease 30.7 THBD PLAT F8 F5 APOH
5 retinal artery occlusion 30.6 PLG F8 F5 APOH
6 branch retinal artery occlusion 30.6 PLG APOH
7 pulmonary edema 30.5 NOS3 IL1B HSPA1A
8 intracranial embolism 30.5 PLG PLAT
9 spinal cord infarction 30.5 F5 APOH
10 cerebral artery occlusion 30.4 NOS3 IL1B BDNF
11 intracranial aneurysm 30.4 PLAT NOS3 CASP3
12 protein s deficiency 30.3 THBD F5 APOH
13 homocystinuria 30.3 THBD F8 F5
14 nonarteritic anterior ischemic optic neuropathy 30.3 NOS3 F5 APOH
15 vascular dementia 30.3 MBP IL1B GRIN2B CASP3
16 antithrombin iii deficiency 30.2 PLG F5 APOH
17 basilar artery occlusion 30.2 PLG PLAT
18 retinal vascular disease 30.2 PLG NOS3 IL1B CASP3
19 antiphospholipid syndrome 30.2 THBD PLAT F5 APOH
20 vertebral artery occlusion 30.1 PLG PLAT
21 factor xi deficiency 30.1 THBD F8 F5 F11
22 carotid artery thrombosis 30.1 PLG PLAT NOS3 F11
23 intracranial hypertension 30.1 IL1B F5 APOH
24 cardiac tamponade 30.1 PLG PLAT F8
25 thrombophlebitis 29.9 PLG PLAT F8 F5 APOH
26 patent foramen ovale 29.9 PLG PLAT F5 APOH
27 thrombophilia due to thrombin defect 29.8 THBD PLAT F8 F5 APOH
28 thrombosis 29.8 THBD PLG PLAT F8 F5 F11
29 vascular disease 29.6 THBD PLG PLAT NOS3 F8 F5
30 intracranial thrombosis 29.5 PLG PLAT F8 F5 F11 APOH
31 optic nerve disease 29.4 MBP IL1B GFAP BDNF
32 cerebral palsy 29.2 PLAT NOS3 IL1B F5 BDNF
33 hydrocephalus 29.1 PLAT MBP GFAP CASP3 BDNF
34 status epilepticus 29.0 GRIN2B GFAP CASP3 BDNF
35 ischemia 28.9 PLG PLAT NOS3 MAP2 HSPA1A GFAP
36 migraine with or without aura 1 28.8 PLG NOS3 IL1B GRIN2B BDNF APOH
37 stroke, ischemic 28.1 THBD RBFOX3 PLG PLAT NOS3 MBP
38 alzheimer disease 27.7 PLAT NOS3 MAP2 LDLR IL1B HSPA1A
39 carotid stenosis 10.8
40 aneurysm 10.8
41 carotid artery disease 10.6
42 hemiplegia 10.6
43 amaurosis fugax 10.6
44 aphasia 10.5
45 asplenia, isolated congenital 10.5
46 ocular motor apraxia 10.5
47 yemenite deaf-blind hypopigmentation syndrome 10.5
48 cerebral aneurysms 10.5
49 chronic enteropathy associated with slco2a1 gene 10.5
50 kearns-sayre syndrome 10.4

Graphical network of the top 20 diseases related to Carotid Artery Occlusion:



Diseases related to Carotid Artery Occlusion

Symptoms & Phenotypes for Carotid Artery Occlusion

MGI Mouse Phenotypes related to Carotid Artery Occlusion:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.34 ADAMTS18 BDNF CASP3 F11 F5 GFAP
2 homeostasis/metabolism MP:0005376 10.33 ADAMTS18 APOH BDNF CASP3 F11 F5
3 behavior/neurological MP:0005386 10.27 BDNF CASP3 F11 F5 GFAP GRIN2B
4 mortality/aging MP:0010768 10.25 APOH BDNF CASP3 F11 F5 F8
5 cardiovascular system MP:0005385 10.22 CASP3 F11 F5 GFAP IL1B LDLR
6 immune system MP:0005387 10.18 ADAMTS18 CASP3 F11 F8 GFAP IL1B
7 digestive/alimentary MP:0005381 10.16 ADAMTS18 BDNF CASP3 GFAP LDLR MYLK
8 nervous system MP:0003631 10.1 BDNF CASP3 F11 F5 GFAP GRIN2B
9 reproductive system MP:0005389 9.85 ADAMTS18 BDNF CASP3 F8 MAP2 MBP
10 respiratory system MP:0005388 9.56 ADAMTS18 BDNF CASP3 F11 NOS3 PLAT
11 vision/eye MP:0005391 9.28 ADAMTS18 BDNF CASP3 GFAP LDLR MBP

Drugs & Therapeutics for Carotid Artery Occlusion

Drugs for Carotid Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
2
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
3 Anti-Inflammatory Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Analgesics, Non-Narcotic Phase 3
6 Fibrinolytic Agents Phase 3
7 Anti-Inflammatory Agents, Non-Steroidal Phase 3
8 Platelet Aggregation Inhibitors Phase 3
9 Analgesics Phase 3
10 Antirheumatic Agents Phase 3
11 Cyclooxygenase Inhibitors Phase 3
12 Purinergic P2Y Receptor Antagonists Phase 3
13 Antipyretics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Active, not recruiting NCT01758614 Phase 3 Aspirin;Clopidogrel
2 Endovascular Revascularization for Chronic Carotid Artery Occlusion Trial (ERCAO Trial) Part 1: Prospective Clinical Registry Study Part 2: Prospective Randomized Control Trial Study Unknown status NCT03179774
3 A Comparison of Cognitive Function After Carotid Endarterectomy and Stenting Completed NCT02220595
4 Sundt™ Carotid Shunt Retrospective Post Market Clinical Follow-up Study (PMCF) Completed NCT03816202
5 Establishment and Practice of Multi-dimensional Evaluation System for Recanalization of Symptomatic Non-acute Carotid Artery Occlusion Recruiting NCT04291430
6 Sensitivity to Acute Middle Cerebral or Intracranial Carotid Artery Occlusion in MIGrainers - SAMCO-MIG Recruiting NCT03301441

Search NIH Clinical Center for Carotid Artery Occlusion

Genetic Tests for Carotid Artery Occlusion

Anatomical Context for Carotid Artery Occlusion

MalaCards organs/tissues related to Carotid Artery Occlusion:

40
Brain, Cortex, Pituitary, Retina, Endothelial, Eye, Spinal Cord

Publications for Carotid Artery Occlusion

Articles related to Carotid Artery Occlusion:

(show top 50) (show all 3395)
# Title Authors PMID Year
1
External carotid artery stenting in patients with ipsilateral internal carotid artery occlusion: Peri-operative and 12-month follow-up. 61
33600036 2021
2
The variation of 18 amino acids' levels in cortex and plasma of cerebral ischemia C57BL/6 mice. 61
33559223 2021
3
Contralateral Carotid Artery Occlusion: Medical Therapy, Carotid Endarterectomy, Carotid Artery Stenting? 61
33602465 2021
4
Outcomes of transcarotid artery revascularization with dynamic flow reversal in patients with contralateral carotid artery occlusion. 61
32569716 2021
5
Outcomes of Carotid Revascularization in Patients with Contralateral Carotid Artery Occlusion. 61
33601006 2021
6
Balloon catheter occlusion of the maxillary, internal, and external carotid arteries in standing horses. 61
33606309 2021
7
qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients. 61
32098584 2021
8
Neuroprotective phosphatidylserine liposomes alleviate depressive-like behavior related to stroke through neuroinflammation attenuation in the mouse hippocampus. 61
33569644 2021
9
Early neurological deterioration following thrombolysis for minor stroke with isolated internal carotid artery occlusion. 61
32959480 2021
10
Inter-hospital transfer for mechanical thrombectomy within the supraregional stroke network NEVAS. 61
32889616 2021
11
Paraneoplastic Syndrome and SARS-CoV-2-Incremental Effect of 2 Thrombogenic Conditions? 61
33106785 2021
12
Horner's syndrome secondary to internal carotid artery occlusion. 61
33542025 2021
13
Involvement of Supraoptic Astrocytes in Basilar Artery Occlusion-Evoked Differential Activation of Vasopressin Neurons and Vasopressin Secretion in Rats. 61
33532897 2021
14
Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis. 61
33548579 2021
15
Long-Term Patency and Final Structure After Superficial Temporal Artery-Middle Cerebral Artery Bypass Surgery: A Retrospective Study. 61
33228957 2021
16
T-Configuration Stent Placement for Carotid Bifurcation Stenosis Co-Existing with Ipsilateral Intracranial Stenosis: A Case Report and Literature Review. 61
33232933 2021
17
Brain Temperature Measured by Magnetic Resonance Spectroscopy to Predict Clinical Outcome in Patients with Infarction. 61
33445603 2021
18
Symptomatic isolated internal carotid artery occlusion with initial medical management: a monocentric cohort. 61
32809152 2021
19
Carnosic acid ameliorates depressive-like symptoms along with the modulation of FGF9 in the hippocampus of middle carotid artery occlusion-induced Sprague Dawley rats. 61
32779789 2021
20
Endovascular Recanalization of Symptomatic Nonacute Intracranial Internal Carotid Artery Occlusion: Proposal of a New Angiographic Classification. 61
33361380 2021
21
GABAB receptor antagonist promotes hippocampal neurogenesis and facilitates cognitive function recovery following acute cerebral ischemia in mice. 61
33413637 2021
22
Anti-apoptotic effect of silymarin-loaded chitosan nanoparticles on hippocampal caspase-3 and Bcl-2 expression following cerebral ischemia/reperfusion injury. 61
33287594 2021
23
Differential contribution of CB1, CB2, 5-HT1A, and PPAR-γ receptors to cannabidiol effects on ischemia-induced emotional and cognitive impairments. 61
33522084 2021
24
Abatement of neurobehavioral and neurochemical dysfunctions in cerebral ischemia/reperfusion injury by Tetrapleura tetraptera fruit extract. 61
32841692 2021
25
Acute Endovascular Revascularization for Patients with Common Carotid Artery Occlusion Apparent on Cervical Magnetic Resonance Angiography. 61
33516069 2021
26
[Severe cerebral haemodynamic impairment treated with bypass surgery]. 61
33491642 2021
27
Thrombus Migration and Fragmentation After Intravenous Alteplase Treatment: The INTERRSeCT Study. 61
33317416 2021
28
[A case of neurogenic pulmonary edema due to left internal carotid artery occlusion]. 61
33328420 2021
29
Rescue permanent LVIS stenting with post-stenting angioplasty after failed mechanical thrombectomy for refractory internal carotid artery occlusion at the paraclinoid segment: two-case report. 61
33423675 2021
30
Nuclear receptor TLX may be through regulating the SIRT1/NF-κB pathway to ameliorate cognitive impairment in chronic cerebral hypoperfusion. 61
33197535 2021
31
Melatonin and/or erythropoietin combined with hypothermia in a piglet model of perinatal asphyxia. 61
33604569 2021
32
The Use of Antiplatelet Agents and Heparin in the 24-Hour Postintravenous Alteplase Window for Neurointervention. 61
33442725 2021
33
Comparison of methods between CT perfusion source images and CT angiography in collateral flow assessment. 61
32228031 2021
34
Carotid occlusion: Impact of cerebral hemodynamic impairment on cognitive performances. 61
32857468 2021
35
Relation of Retinal Oxygen Measures to Electrophysiology and Survival Indicators after Permanent, Incomplete Ischemia in Rats. 61
32207038 2020
36
Commentary: Subclavian Artery to Internal Carotid Artery Interpositional Bypass for Carotid Artery Occlusion: Technical Case Report. 61
32895717 2020
37
Subclavian Artery to Internal Carotid Artery Interpositional Bypass for Carotid Artery Occlusion: Technical Case Report. 61
32895699 2020
38
Acute Internal Carotid Artery Occlusion Long after Carotid Revascularization by Vein Graft. 61
33096496 2020
39
Chronic total occlusion and spontaneous recanalization of the internal carotid artery: Natural history and management strategy. 61
33297876 2020
40
Common Carotid Artery Occlusion in a Young Patient: Can Large-Vessel Stroke Be the Initial Clinical Manifestation of Coronavirus Disease 2019? 61
32889184 2020
41
Mechanical Thrombectomy for Acute Intracranial Carotid Occlusion with Patent Intracranial Arteries : The Italian Registry of Endovascular Treatment in Acute Stroke. 61
33301052 2020
42
Reperfusion treatment in acute ischaemic stroke due to cervical and cerebral artery dissection: results of a Spanish national multicentre study. 61
33358059 2020
43
Carotid artery stenting before surgery for carotid artery occlusion associated with acute type A aortic dissection: Two case reports. 61
32397860 2020
44
[A Case Report of Subacute Thrombosis after Carotid Stenting Caused by Food Allergy]. 61
33353878 2020
45
[A Case of Traumatic Carotid Artery Dissection Treated with Mechanical Thrombectomy Followed by Carotid Artery Stenting]. 61
33353880 2020
46
Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia. 61
33346090 2020
47
A mouse model of retinal hypoperfusion injury induced by unilateral common carotid artery occlusion. 61
32991884 2020
48
Novel triple coaxial system to navigate 9 French balloon guiding catheter into common carotid artery. 61
32501178 2020
49
Influence of contralateral carotid artery occlusions on short- and long-term outcomes of carotid artery stenting: a retrospective single-centre analysis and review of literature. 61
33274909 2020
50
Restoration of the attenuated neuroprotective effect of ischemic postconditioning in diabetic mice by SGLT inhibitor Phlorizin. 61
33319687 2020

Variations for Carotid Artery Occlusion

ClinVar genetic disease variations for Carotid Artery Occlusion:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 LDLR NM_000527.5(LDLR):c.682G>A (p.Glu228Lys) SNV Pathogenic 3691 19:11216264-11216264 19:11105588-11105588
2 MYLK NM_053025.4(MYLK):c.2149G>A (p.Asp717Asn) SNV Uncertain significance 519975 rs150936840 3:123426842-123426842 3:123707995-123707995

Expression for Carotid Artery Occlusion

Search GEO for disease gene expression data for Carotid Artery Occlusion.

Pathways for Carotid Artery Occlusion

Pathways related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 THBD PLG PLAT NOS3 F8 F5
2 12.34 RBFOX3 MBP MAP2 GRIN2B GFAP
3
Show member pathways
12.16 PLG PLAT LDLR IL1B
4
Show member pathways
12.08 MBP MAP2 LDLR CASP3
5
Show member pathways
12.07 LDLR IL1B HSPA1A CASP3
6 11.94 MAP2 IL1B CASP3 BDNF
7 11.81 THBD PLAT NOS3 IL1B
8 11.63 MBP IL1B GFAP CASP3 BDNF
9
Show member pathways
11.63 THBD PLG PLAT F8 F5 F11
10 11.61 MAP2 GFAP BDNF
11 11.56 THBD NOS3 IL1B CASP3
12
Show member pathways
11.51 PLG CASP3 BDNF
13 11.41 IL1B HSPA1A CASP3
14 11.26 THBD PLG PLAT F8 F5 F11
15 10.7 CASP3 BDNF
16 10.66 PLG PLAT

GO Terms for Carotid Artery Occlusion

Cellular components related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 THBD PLG PLAT IL1B F8 F5
2 extracellular region GO:0005576 9.65 PLG PLAT IL1B HSPA1A F8 F5
3 platelet alpha granule lumen GO:0031093 9.43 PLG F8 F5
4 cell surface GO:0009986 9.17 THBD PLG PLAT MBP LDLR GRIN2B

Biological processes related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.73 THBD NOS3 IL1B CASP3
2 platelet degranulation GO:0002576 9.67 PLG F8 F5 APOH
3 blood coagulation, intrinsic pathway GO:0007597 9.5 F8 F11 APOH
4 negative regulation of blood coagulation GO:0030195 9.49 THBD APOH
5 regulation of blood coagulation GO:0030193 9.48 F11 APOH
6 negative regulation of platelet activation GO:0010544 9.46 THBD NOS3
7 plasminogen activation GO:0031639 9.43 PLAT F11 APOH
8 blood coagulation GO:0007596 9.43 THBD PLG PLAT F8 F5 F11
9 positive regulation of fibrinolysis GO:0051919 9.4 PLG F11
10 negative regulation of fibrinolysis GO:0051918 9.33 THBD PLG APOH
11 hemostasis GO:0007599 9.02 THBD PLG F8 F5 F11

Molecular functions related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.35 PLG PLAT F11 CASP3 ADAMTS18
2 protease binding GO:0002020 9.33 MBP LDLR CASP3
3 calmodulin binding GO:0005516 8.92 NOS3 MYLK MBP MAP2

Sources for Carotid Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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