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MCID: CRT015
MIFTS: 44

Carotid Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Carotid Artery Occlusion

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MalaCards integrated aliases for Carotid Artery Occlusion:

Name: Carotid Artery Occlusion 12 6 15 74
Occlusion and Stenosis of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:807
ICD9CM 36 433.10
ICD10 34 I65.2
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Summaries for Carotid Artery Occlusion

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MalaCards based summary : Carotid Artery Occlusion, also known as occlusion and stenosis of carotid artery, is related to ischemia and thrombosis. An important gene associated with Carotid Artery Occlusion is LDLR (Low Density Lipoprotein Receptor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and G-protein signaling Ras family GTPases in kinase cascades (scheme). The drugs Abciximab and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and testes, and related phenotypes are growth/size/body region and homeostasis/metabolism

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Related Diseases for Carotid Artery Occlusion

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Diseases related to Carotid Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 ischemia 31.0 HSPA1A MAP2 NOS3
2 thrombosis 30.4 APOH F5 F8 THBD
3 spinal cord infarction 30.2 APOH F5
4 transient cerebral ischemia 30.2 APOH HSPA1A MAP2
5 ischemic optic neuropathy 30.0 APOH F5 NOS3
6 antiphospholipid syndrome 30.0 APOH F5 THBD
7 thrombophilia due to thrombin defect 29.7 APOH F5 F8 THBD
8 vascular disease 29.4 APOH F5 LDLR NOS3 THBD
9 stroke, ischemic 29.3 APOH F5 MAP2 MBP NOS3 THBD
10 moyamoya disease 1 11.7
11 acquired hemophilia 10.3 F5 F8
12 acquired hemophilia a 10.3 F5 F8
13 hemophilia a 10.3 F5 F8
14 factor v and factor viii, combined deficiency of, 2 10.3 F5 F8
15 may-thurner syndrome 10.3 APOH F5
16 priapism 10.3 F5 NOS3
17 factor viii deficiency 10.3 F5 F8
18 acanthamoeba keratitis 10.3 APOH F5
19 sudden sensorineural hearing loss 10.3 APOH F5
20 cerebral sinovenous thrombosis 10.3 APOH F5
21 pregnancy loss, recurrent 1 10.3 APOH F5
22 breast reconstruction 10.3 APOH F8
23 factor xiii deficiency 10.3 F5 F8
24 prothrombin deficiency, congenital 10.3 APOH F5
25 ischemic colitis 10.3 APOH F5
26 catastrophic antiphospholipid syndrome 10.3 APOH F5
27 post-thrombotic syndrome 10.3 F5 F8
28 meningococcemia 10.3 F5 THBD
29 retinal vascular occlusion 10.3 APOH F5
30 livedoid vasculitis 10.3 APOH F8
31 carotid stenosis 10.3
32 antithrombin iii deficiency 10.3 APOH F5
33 raynaud phenomenon 10.3 APOH THBD
34 peripheral vertigo 10.3 APOH F5
35 buerger disease 10.3 APOH NOS3
36 mucormycosis 10.2
37 central retinal vein occlusion 10.2 APOH F5
38 retinal vein occlusion 10.2 APOH F5
39 factor xii deficiency 10.2 APOH F5
40 arteritic anterior ischemic optic neuropathy 10.2 F5 NOS3
41 pericardium cancer 10.2 F8 THBD
42 acute mountain sickness 10.2 HSPA1A NOS3
43 dysfibrinogenemia 10.2 F5 THBD
44 portal vein thrombosis 10.2 APOH F5
45 blood coagulation disease 10.2 F5 F8 THBD
46 hepatic infarction 10.2 APOH CA4
47 hemorrhagic disease 10.2 F5 F8 THBD
48 thrombophlebitis 10.2 APOH F5 F8
49 intracranial thrombosis 10.2 APOH F5 F8
50 cerebral aneurysms 10.1

Graphical network of the top 20 diseases related to Carotid Artery Occlusion:



Diseases related to Carotid Artery Occlusion
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Symptoms & Phenotypes for Carotid Artery Occlusion

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MGI Mouse Phenotypes related to Carotid Artery Occlusion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 ADAMTS18 BCO1 CA4 F5 LDLR MAP2
2 homeostasis/metabolism MP:0005376 9.85 ADAMTS18 APOH BCO1 CA4 F5 F8
3 mortality/aging MP:0010768 9.61 APOH CA4 F5 F8 LDLR MAP2
4 reproductive system MP:0005389 9.17 ADAMTS18 CA4 F8 MAP2 MBP NOS3
Sources

Drugs & Therapeutics for Carotid Artery Occlusion

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Drugs for Carotid Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Plasminogen Phase 4,Phase 1,Phase 2,Not Applicable
3 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable
4 Tissue Plasminogen Activator Phase 4,Phase 1,Phase 2,Not Applicable
5 Platelet Aggregation Inhibitors Phase 4,Phase 3
6 Anticoagulants Phase 4
7
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
8
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
9
Fenofibrate Approved Phase 3 49562-28-9 3339
10
Ezetimibe Approved Phase 3 163222-33-1 150311
11
Xylometazoline Approved, Investigational Phase 3 526-36-3 5709
12 Antipyretics Phase 3
13 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
14 Purinergic P2Y Receptor Antagonists Phase 3
15 Cyclooxygenase Inhibitors Phase 3
16 Neurotransmitter Agents Phase 3,Phase 1,Phase 2
17 Anti-Inflammatory Agents Phase 3
18 Antirheumatic Agents Phase 3
19 Analgesics, Non-Narcotic Phase 3
20 Analgesics Phase 3,Phase 1,Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3
22 Purinergic P2 Receptor Antagonists Phase 3
23 Pharmaceutical Solutions Phase 3
24 Antibodies, Monoclonal Phase 3
25 Antibodies Phase 3
26 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
27 Immunoglobulins Phase 3
28 Immunologic Factors Phase 3
29
Ketamine Approved, Vet_approved Phase 1, Phase 2 6740-88-1 3821
30 Anesthetics, Intravenous Phase 1, Phase 2
31 Excitatory Amino Acid Antagonists Phase 1, Phase 2
32 Anesthetics Phase 1, Phase 2,Not Applicable
33 Anesthetics, General Phase 1, Phase 2
34 Anesthetics, Dissociative Phase 1, Phase 2
35 Central Nervous System Depressants Phase 1, Phase 2
36 Excitatory Amino Acids Phase 1, Phase 2

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
2 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
3 Phase III Study To Evaluate Alirocumab in Patients With Hypercholesterolemia Not Treated With a Statin (ODYSSEY CHOICE II) Completed NCT02023879 Phase 3 Alirocumab;Placebo (for Alirocumab);Non-statin LMT
4 Carotid Occlusion Surgery Study Terminated NCT00029146 Phase 3 best medical therapy
5 Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting Terminated NCT00395785 Phase 2, Phase 3
6 Ketamine for Thrombolysis in Acute Ischemic Stroke Unknown status NCT02258204 Phase 1, Phase 2 Ketamine;Placebo
7 Prediction of Carotid Occlusion Intolerance by Transcranial Doppler Evaluation in Patients Undergoing Carotid Artery Stenting With Proximal Flow Arrest Protection System. Unknown status NCT01922609
8 Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A) Unknown status NCT02811536
9 Study of Carotid Occlusion and Neurocognition Completed NCT00390481 Not Applicable
10 Aneurysms and Carotid Artery Block in Newborns Completed NCT00646672
11 Postapproval Trial On Carotid Stenting in Patients With High Risk Vs Standard Risk for Open Carotid Endarterectomy(REAL) Completed NCT02750644
12 Medical Imaging Characteristics of Patient With Unclassified Acute Cervical Pain Completed NCT03690882
13 Molecular Mechanisms and Carotid Atherosclerosis Completed NCT03962686 MetFORMIN 1000 Mg Oral Tablet
14 Endovascular Revascularization for Chronic Carotid Artery Occlusion Trial Recruiting NCT03179774 Not Applicable
15 Sensitivity to Acute Cerebral Ischemia in Migrainers Recruiting NCT03301441
16 STAMCAR: A Prospective EC-IC Bypass Registry Recruiting NCT02779803
17 Post-market, Prospective Evaluation of PHOTO-oxidized Bovine Pericardium in Vascular Surgery Recruiting NCT03669042 Not Applicable
18 CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHDâ„¢ Recruiting NCT03179800 Not Applicable
19 Sundtâ„¢ Carotid Shunt Retrospective Post Market Clinical Follow-up Study (PMCF) Not yet recruiting NCT03816202
20 Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase Terminated NCT02216565 Not Applicable Alteplase if patient is eligible
21 Endovascular Revascularization of Symptomatic Chronically Occluded Internal Carotid Artery Withdrawn NCT03176420 Not Applicable

Search NIH Clinical Center for Carotid Artery Occlusion

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Genetic Tests for Carotid Artery Occlusion

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Anatomical Context for Carotid Artery Occlusion

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MalaCards organs/tissues related to Carotid Artery Occlusion:

42
Brain, Pituitary, Testes, Eye, Retina, Breast, Cortex
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Publications for Carotid Artery Occlusion

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Articles related to Carotid Artery Occlusion:

(show top 50) (show all 873)
# Title Authors Year
1
Resveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion. ( 31052460 )
2019
2
Molecular Alterations and Effects of Acute Dehydroepiandrosterone Treatment Following Brief Bilateral Common Carotid Artery Occlusion: Relevance to Transient Ischemic Attack. ( 31095985 )
2019
3
Management of Cavernous Sinus Meningioma Presenting With Cerebrovascular Insufficiency Secondary to Cavernous Carotid Artery Occlusion: Report of 2 Cases. ( 29850864 )
2019
4
Impact of external carotid artery occlusion at declamping of the external and common carotid arteries during carotid endarterectomy on development of new postoperative ischemic cerebral lesions. ( 29960793 )
2019
5
Recanalization of Acute Common Carotid Artery Occlusion: 2-Dimensional Operative Video. ( 30099507 )
2019
6
Commentary: Recanalization of Acute Common Carotid Artery Occlusion: 2-Dimensional Operative Video. ( 30247669 )
2019
7
Acute Stroke Treatment by Surgical Recanalization of Extracranial Internal Carotid Artery Occlusion: A Single Center Experience. ( 30301430 )
2019
8
Long-term outcomes of carotid artery stenting in patients with a contralateral carotid artery occlusion. ( 30351515 )
2019
9
Differential regional infarction, neuronal loss and gliosis in the gerbil cerebral hemisphere following 30 min of unilateral common carotid artery occlusion. ( 30443768 )
2019
10
Vessel Wall Injury After Stent Retriever Thrombectomy for Internal Carotid Artery Occlusion with Duplicated Middle Cerebral Artery. ( 30529524 )
2019
11
A modified encephalo-duro-synagiosis technique induced neovascularization in symptomatic atherosclerotic carotid artery occlusion: A Phase 1 trial. ( 30615994 )
2019
12
Internal Carotid Artery Occlusion Causing Acute Cranial Neuropathies. ( 30638944 )
2019
13
Functional and morphologic study of retinal hypoperfusion injury induced by bilateral common carotid artery occlusion in rats. ( 30643163 )
2019
14
Intravenous Milrinone Salvage Therapy in Acute Internal Carotid Artery Occlusion: Case Report. ( 30661227 )
2019
15
Efficacy and Safety of Endovascular Treatment in Patients with Internal Carotid Artery Occlusion and Collateral Middle Cerebral Artery Flow. ( 30840975 )
2019
16
Superficial Temporal Artery Trunk-to-Middle Cerebral Artery Bypass with Short Radial Artery Interposition Graft for Symptomatic Internal Carotid Artery Occlusion. ( 30898742 )
2019
17
Cardiac surgery in the presence of chronic internal carotid artery occlusion. ( 30904987 )
2019
18
Diagnosis of Rhinocerebral Mucormycosis by Treatment of Cavernous Right Internal Carotid Artery Occlusion With Mechanical Thrombectomy: Special Case Presentation and Literature Review. ( 30972005 )
2019
19
Does Universal Bypass before Carotid Artery Occlusion Obviate the Need for Balloon Test Occlusion: Personal Experience with Extracranial-Intracranial Bypass in 23 Patients. ( 31001004 )
2019
20
Clinical efficacy of collateral circulation in the evaluation of endovascular treatment for acute internal carotid artery occlusion. ( 31008404 )
2019
21
Comparison of postoperative results between carotid endarterectomy and carotid artery stenting for patients with contralateral carotid artery occlusion: A meta-analysis. ( 31027468 )
2019
22
Relay-balloon technique for recanalization of acute symptomatic proximal internal carotid artery occlusion with short balloon-tipped guiding catheter landing zone. ( 28108499 )
2018
23
Rationale for graft selection in patients with complex internal carotid artery aneurysms treated with extracranial to intracranial high-flow bypass and therapeutic internal carotid artery occlusion. ( 28574313 )
2018
24
The Occipital Artery as an Alternative Donor for Low-Flow Bypass to Anterior Circulation After Internal Carotid Artery Occlusion Failure prior to Exenteration for an Atypical Cavernous Sinus Meningioma. ( 28887285 )
2018
25
Usefulness of contralateral carotid angiography in revascularization therapy of acute internal carotid artery occlusion. ( 28946180 )
2018
26
Pretemporal ("Half-and-Half") Approach for Posterior Circulation Aneurysms in a Patient With Internal Carotid Artery Occlusion. ( 28961943 )
2018
27
Diagnostic accuracy of emergency CT angiography for presumed tandem internal carotid artery occlusion before acute endovascular therapy. ( 29101306 )
2018
28
Combined interventional and surgical treatment of tandem middle cerebral artery embolus and internal carotid artery occlusion: case report. ( 29148900 )
2018
29
Carotid-Carotid Artery Crossover Bypass with a Synthetic Vascular Graft for Symptomatic Type 1A Common Carotid Artery Occlusion. ( 29269063 )
2018
30
Coexistent Ipsilateral Internal Carotid Artery Occlusion and Cerebral Venous Thrombosis in Hepatitis C. ( 29349091 )
2018
31
Evaluation of revascularization after total arch replacement in common carotid artery occlusion. ( 29376064 )
2018
32
Simple aspiration with balloon catheter technique (simple ABC technique) against proximal internal carotid artery occlusion in cases of cardiogenic cerebral embolism. ( 29378450 )
2018
33
Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. ( 29385102 )
2018
34
Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion. ( 29402275 )
2018
35
Three-Year Clinical Results of Carotid Artery Stenting in Treating Patients with Contralateral Carotid Artery Occlusion. ( 29428329 )
2018
36
Poststroke epilepsy following transient unilateral middle cerebral and common carotid artery occlusion in young adult and aged F344 rats. ( 29455049 )
2018
37
Cervical Internal Carotid Artery Occlusion versus Pseudo-Occlusion: Can CT Angiography Help Distinguish These in the Acute Stroke Setting? ( 29461944 )
2018
38
Circle of Willis Collateral Flow in Carotid Artery Occlusion Is Depicted by 4D-CTA. ( 29530689 )
2018
39
Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). ( 29547662 )
2018
40
Potential of carnosine, a histamine precursor in rat model of bilateral common carotid artery occlusion-induced vascular dementia. ( 29676814 )
2018
41
Correction: Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). ( 29684064 )
2018
42
Clinical Significance of the Circle of Willis in Patients with Symptomatic Internal Carotid Artery Occlusion. ( 29702309 )
2018
43
Angioplasty and stenting for symptomatic extracranial non-tandem internal carotid artery occlusion. ( 29706606 )
2018
44
Alarming Results for Carotid Artery Stenting in Patients with Contralateral Carotid Artery Occlusion. ( 29729843 )
2018
45
High-resolution magnetic resonance vessel wall imaging of chronic intracranial internal carotid artery occlusion. ( 29752977 )
2018
46
Gastrodin Attenuates Bilateral Common Carotid Artery Occlusion-Induced Cognitive Deficits via Regulating Aβ-Related Proteins and Reducing Autophagy and Apoptosis in Rats. ( 29755351 )
2018
47
Disappearance of Ruptured Posterior Cerebral Artery Aneurysm Associated with Internal Carotid Artery Occlusion After Superficial Temporal Artery-to-Middle Cerebral Artery Bypass. ( 29803057 )
2018
48
Ring-Stripping Retrograde Endarterectomy for Treatment of Common Carotid Artery Occlusion: A Minimally Invasive, Effective Procedure. ( 29885429 )
2018
49
Symptomatic Bilateral Carotid Artery Occlusion: An Uncommon Pattern of Carotid Pathology. ( 29984215 )
2018
50
A Case of Rapid Malignant Brain Swelling Subacutely After Reperfusion Therapy for Internal Carotid Artery Occlusion. ( 30055370 )
2018
Sources

Variations for Carotid Artery Occlusion

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ClinVar genetic disease variations for Carotid Artery Occlusion:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 LDLR NM_000527.4(LDLR): c.682G> A (p.Glu228Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121908029 GRCh37 Chromosome 19, 11216264: 11216264
2 LDLR NM_000527.4(LDLR): c.682G> A (p.Glu228Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121908029 GRCh38 Chromosome 19, 11105588: 11105588
3 MYLK NM_053025.3(MYLK): c.2149G> A (p.Asp717Asn) single nucleotide variant Uncertain significance rs150936840 GRCh38 Chromosome 3, 123707995: 123707995
4 MYLK NM_053025.3(MYLK): c.2149G> A (p.Asp717Asn) single nucleotide variant Uncertain significance rs150936840 GRCh37 Chromosome 3, 123426842: 123426842
Sources

Expression for Carotid Artery Occlusion

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Search GEO for disease gene expression data for Carotid Artery Occlusion.
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Pathways for Carotid Artery Occlusion

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Pathways related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 12.88 APOH F5 F8 NOS3 THBD
2
G-protein signaling Ras family GTPases in kinase cascades (scheme) 23
Show member pathways
 11.8 LDLR MAP2 MBP
3
Formation of Fibrin Clot (Clotting Cascade) 67
Show member pathways
 11.33 F5 F8 THBD
4
Complement and coagulation cascades 1 38
10.94 F5 F8 THBD
5
Erythrocytes take up carbon dioxide and release oxygen 67
Show member pathways
 10.87 CA1 CA4
6
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
10.79 NOS3 THBD
7
Nitrogen metabolism 38
Show member pathways
 10.62 CA1 CA4
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GO Terms for Carotid Artery Occlusion

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Cellular components related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 APOH CA4 LDLR MBP THBD
2 COPII-coated ER to Golgi transport vesicle GO:0030134 8.96 F5 F8

Biological processes related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.58 F5 F8 THBD
2 platelet degranulation GO:0002576 9.5 APOH F5 F8
3 bicarbonate transport GO:0015701 9.43 CA1 CA4
4 blood coagulation, intrinsic pathway GO:0007597 9.37 APOH F8
5 negative regulation of blood coagulation GO:0030195 9.26 APOH THBD
6 negative regulation of fibrinolysis GO:0051918 9.16 APOH THBD
7 negative regulation of platelet activation GO:0010544 8.96 NOS3 THBD
8 hemostasis GO:0007599 8.8 F5 F8 THBD

Molecular functions related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.13 MAP2 MBP NOS3
2 carbonate dehydratase activity GO:0004089 8.62 CA1 CA4
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Sources for Carotid Artery Occlusion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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