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MCID: CRT015
MIFTS: 43

Carotid Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Carotid Artery Occlusion

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MalaCards integrated aliases for Carotid Artery Occlusion:

Name: Carotid Artery Occlusion 12 15 73
Occlusion and Stenosis of Carotid Artery 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:807
ICD9CM 35 433.10
ICD10 33 I65.2
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Summaries for Carotid Artery Occlusion

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MalaCards based summary : Carotid Artery Occlusion, also known as occlusion and stenosis of carotid artery, is related to ischemia and thrombosis. An important gene associated with Carotid Artery Occlusion is HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Abciximab and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and retina, and related phenotypes are growth/size/body region and homeostasis/metabolism

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Related Diseases for Carotid Artery Occlusion

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Diseases related to Carotid Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.9 HSPA1A MAP2 NOS3
2 thrombosis 30.3 APOH F5 F8 THBD
3 spinal cord infarction 30.0 APOH F5
4 nonarteritic anterior ischemic optic neuropathy 29.9 F5 NOS3
5 ischemic optic neuropathy 29.9 APOH F5 NOS3
6 antiphospholipid syndrome 29.8 APOH F5 THBD
7 transient cerebral ischemia 29.7 APOH HSPA1A MAP2
8 vascular disease 29.7 APOH F5 NOS3 THBD
9 thrombophilia due to thrombin defect 29.6 APOH F5 F8 THBD
10 stroke, ischemic 29.6 APOH F5 MAP2 MBP NOS3 THBD
11 moyamoya disease 1 11.7
12 acquired hemophilia 10.2 F5 F8
13 acquired hemophilia a 10.2 F5 F8
14 priapism 10.2 F5 NOS3
15 hemophilia a 10.2 F5 F8
16 may-thurner syndrome 10.2 APOH F5
17 factor v and factor viii, combined deficiency of, 2 10.2 F5 F8
18 acanthamoeba keratitis 10.2 APOH F5
19 factor viii deficiency 10.2 F5 F8
20 sudden sensorineural hearing loss 10.2 APOH F5
21 cerebral sinovenous thrombosis 10.2 APOH F5
22 pregnancy loss, recurrent 1 10.2 APOH F5
23 breast reconstruction 10.2 APOH F8
24 prothrombin deficiency, congenital 10.2 APOH F5
25 ischemic colitis 10.2 APOH F5
26 catastrophic antiphospholipid syndrome 10.2 APOH F5
27 factor xiii deficiency 10.2 F5 F8
28 post-thrombotic syndrome 10.2 F5 F8
29 retinal vascular occlusion 10.2 APOH F5
30 buerger disease 10.2 APOH NOS3
31 livedoid vasculitis 10.2 APOH F8
32 mucormycosis 10.2
33 acute mountain sickness 10.2 HSPA1A NOS3
34 antithrombin iii deficiency 10.2 APOH F5
35 peripheral vertigo 10.2 APOH F5
36 meningococcemia 10.2 F5 THBD
37 arteritic anterior ischemic optic neuropathy 10.2 F5 NOS3
38 central retinal vein occlusion 10.2 APOH F5
39 retinal vein occlusion 10.2 APOH F5
40 factor xii deficiency 10.2 APOH F5
41 raynaud phenomenon 10.2 APOH THBD
42 portal vein thrombosis 10.1 APOH F5
43 pericardium cancer 10.1 F8 THBD
44 cerebral aneurysms 10.1
45 protein s deficiency 10.1 APOH F5
46 dysfibrinogenemia 10.1 F5 THBD
47 vein disease 10.1 F5 F8
48 hepatic infarction 10.1 APOH CA4
49 protein c deficiency 10.1 F5 THBD
50 transverse myelitis 10.1 APOH MBP

Graphical network of the top 20 diseases related to Carotid Artery Occlusion:



Diseases related to Carotid Artery Occlusion
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Symptoms & Phenotypes for Carotid Artery Occlusion

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MGI Mouse Phenotypes related to Carotid Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 ADAMTS18 BCO1 CA4 F5 MAP2 MBP
2 homeostasis/metabolism MP:0005376 9.61 ADAMTS18 APOH BCO1 CA4 F5 F8
3 reproductive system MP:0005389 9.17 ADAMTS18 CA4 F8 MAP2 MBP NOS3
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Drugs & Therapeutics for Carotid Artery Occlusion

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Drugs for Carotid Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Plasminogen Phase 4,Phase 1,Phase 2,Not Applicable
3 Tissue Plasminogen Activator Phase 4,Phase 1,Phase 2,Not Applicable
4 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable
5 Platelet Aggregation Inhibitors Phase 4,Phase 3
6 Antibodies Phase 4,Phase 3
7 Immunoglobulins Phase 4,Phase 3
8 Antibodies, Monoclonal Phase 4,Phase 3
9 Immunologic Factors Phase 4,Phase 3
10 Anticoagulants Phase 4
11 Immunoglobulin Fab Fragments Phase 4
12
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
13
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
14
Ticlopidine Approved Phase 3 55142-85-3 5472
15
Fenofibrate Approved Phase 3 49562-28-9 3339
16
Ezetimibe Approved Phase 3 163222-33-1 150311
17
Xylometazoline Approved, Investigational Phase 3 526-36-3 5709
18 Analgesics, Non-Narcotic Phase 3
19 Purinergic P2Y Receptor Antagonists Phase 3
20 Analgesics Phase 3,Phase 1,Phase 2
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
23 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
24 Anti-Inflammatory Agents, Non-Steroidal Phase 3
25 Purinergic P2 Receptor Antagonists Phase 3
26 Antirheumatic Agents Phase 3
27 Cyclooxygenase Inhibitors Phase 3
28 Neurotransmitter Agents Phase 3,Phase 1,Phase 2
29 Antipyretics Phase 3
30 Anti-Inflammatory Agents Phase 3
31 Pharmaceutical Solutions Phase 3
32 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
33
Ketamine Approved, Vet_approved Phase 1, Phase 2 6740-88-1 3821
34 Anesthetics, Intravenous Phase 1, Phase 2
35 Anesthetics, Dissociative Phase 1, Phase 2
36 Excitatory Amino Acids Phase 1, Phase 2
37 Central Nervous System Depressants Phase 1, Phase 2
38 Anesthetics, General Phase 1, Phase 2
39 Anesthetics Phase 1, Phase 2,Not Applicable
40 Excitatory Amino Acid Antagonists Phase 1, Phase 2

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
2 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
3 Phase III Study To Evaluate Alirocumab in Patients With Hypercholesterolemia Not Treated With a Statin (ODYSSEY CHOICE II) Completed NCT02023879 Phase 3 Alirocumab;Placebo (for Alirocumab);Non-statin LMT
4 Carotid Occlusion Surgery Study Terminated NCT00029146 Phase 3 best medical therapy
5 Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting Terminated NCT00395785 Phase 2, Phase 3
6 Ketamine for Thrombolysis in Acute Ischemic Stroke Unknown status NCT02258204 Phase 1, Phase 2 Ketamine;Placebo
7 Prediction of Carotid Occlusion Intolerance by Transcranial Doppler Evaluation in Patients Undergoing Carotid Artery Stenting With Proximal Flow Arrest Protection System. Unknown status NCT01922609
8 Study of Carotid Occlusion and Neurocognition Completed NCT00390481 Not Applicable
9 Aneurysms and Carotid Artery Block in Newborns Completed NCT00646672
10 Postapproval Trial On Carotid Stenting in Patients With High Risk Vs Standard Risk for Open Carotid Endarterectomy(REAL) Completed NCT02750644
11 Medical Imaging Characteristics of Patient With Unclassified Acute Cervical Pain Completed NCT03690882
12 Endovascular Revascularization for Chronic Carotid Artery Occlusion Trial Recruiting NCT03179774 Not Applicable
13 Sensitivity to Acute Cerebral Ischemia in Migrainers Recruiting NCT03301441
14 STAMCAR: A Prospective EC-IC Bypass Registry Recruiting NCT02779803
15 Post-market, Prospective Evaluation of PHOTO-oxidized Bovine Pericardium in Vascular Surgery Recruiting NCT03669042 Not Applicable
16 Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A) Recruiting NCT02811536
17 CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHD™ Recruiting NCT03179800 Not Applicable
18 Sundt™ Carotid Shunt Retrospective Post Market Clinical Follow-up Study (PMCF) Not yet recruiting NCT03816202
19 Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase Terminated NCT02216565 Not Applicable Alteplase if patient is eligible
20 Endovascular Revascularization of Symptomatic Chronically Occluded Internal Carotid Artery Withdrawn NCT03176420 Not Applicable

Search NIH Clinical Center for Carotid Artery Occlusion

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Genetic Tests for Carotid Artery Occlusion

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Anatomical Context for Carotid Artery Occlusion

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MalaCards organs/tissues related to Carotid Artery Occlusion:

41
Brain, Testes, Retina, Pituitary, Breast, Spinal Cord, Placenta
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Publications for Carotid Artery Occlusion

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Articles related to Carotid Artery Occlusion:

(show top 50) (show all 860)
# Title Authors Year
1
Management of Cavernous Sinus Meningioma Presenting With Cerebrovascular Insufficiency Secondary to Cavernous Carotid Artery Occlusion: Report of 2 Cases. ( 29850864 )
2018
2
Three-Year Clinical Results of Carotid Artery Stenting in Treating Patients with Contralateral Carotid Artery Occlusion. ( 29428329 )
2018
3
Potential of carnosine, a histamine precursor in rat model of bilateral common carotid artery occlusion-induced vascular dementia. ( 29676814 )
2018
4
Correction: Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). ( 29684064 )
2018
5
Cervical Internal Carotid Artery Occlusion versus Pseudo-Occlusion: Can CT Angiography Help Distinguish These in the Acute Stroke Setting? ( 29461944 )
2018
6
Coexistent Ipsilateral Internal Carotid Artery Occlusion and Cerebral Venous Thrombosis in Hepatitis C. ( 29349091 )
2018
7
Evaluation of revascularization after total arch replacement in common carotid artery occlusion. ( 29376064 )
2018
8
Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). ( 29547662 )
2018
9
Ring-stripping retrograde endarterectomy for treatment of common carotid artery occlusion: a minimally invasive, effective procedure. ( 29885429 )
2018
10
Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion. ( 29402275 )
2018
11
Simple aspiration with balloon catheter technique (simple ABC technique) against proximal internal carotid artery occlusion in cases of cardiogenic cerebral embolism. ( 29378450 )
2018
12
Circle of Willis Collateral Flow in Carotid Artery Occlusion Is Depicted by 4D-CTA. ( 29530689 )
2018
13
Gastrodin Attenuates Bilateral Common Carotid Artery Occlusion-Induced Cognitive Deficits via Regulating AI^-Related Proteins and Reducing Autophagy and Apoptosis in Rats. ( 29755351 )
2018
14
Poststroke epilepsy following transient unilateral middle cerebral and common carotid artery occlusion in young adult and aged F344 rats. ( 29455049 )
2018
15
Clinical Significance of the Circle of Willis in Patients with Symptomatic Internal Carotid Artery Occlusion. ( 29702309 )
2018
16
High-resolution magnetic resonance vessel wall imaging of chronic intracranial internal carotid artery occlusion. ( 29752977 )
2018
17
Disappearance of a ruptured posterior cerebral artery aneurysm associated with internal carotid artery occlusion after superficial temporal artery to middle cerebral artery bypass. ( 29803057 )
2018
18
Angioplasty and stenting for symptomatic extracranial non-tandem internal carotid artery occlusion. ( 29706606 )
2018
19
Impact of external carotid artery occlusion at declamping of the external and common carotid arteries during carotid endarterectomy on development of new postoperative ischemic cerebral lesions. ( 29960793 )
2018
20
Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. ( 29385102 )
2018
21
Alarming Results for Carotid Artery Stenting in Patients with Contralateral Carotid Artery Occlusion. ( 29729843 )
2018
22
Symptomatic Bilateral Carotid Artery Occlusion: An Uncommon Pattern of Carotid Pathology. ( 29984215 )
2018
23
A Case of Rapid Malignant Brain Swelling Subacutely After Reperfusion Therapy for Internal Carotid Artery Occlusion. ( 30055370 )
2018
24
Recanalization of Acute Common Carotid Artery Occlusion: 2-Dimensional Operative Video. ( 30099507 )
2018
25
Long-term Outcomes After Endovascular Recanalization in Patients with Chronic Carotid Artery Occlusion. ( 30244843 )
2018
26
Commentary: Recanalization of Acute Common Carotid Artery Occlusion: 2-Dimensional Operative Video. ( 30247669 )
2018
27
Cognitive functioning in patients with carotid artery occlusion; a systematic review. ( 30261428 )
2018
28
Gradual common carotid artery occlusion as a novel model for cerebrovascular Hypoperfusion. ( 30267298 )
2018
29
Cerebral Bypass Surgery for Internal Carotid Artery Occlusion, Complex Supraclinoid Carotid Artery Aneurysm, and Tumors: A Report of Four Cases. ( 30283588 )
2018
30
Acute Stroke Treatment by Surgical Recanalization of Extracranial Internal Carotid Artery Occlusion: A Single Center Experience. ( 30301430 )
2018
31
Long-term outcomes of carotid artery stenting in patients with a contralateral carotid artery occlusion. ( 30351515 )
2018
32
Convexity subarachnoid haemorrhage associated with ipsilateral carotid artery occlusion. ( 30442445 )
2018
33
Differential regional infarction, neuronal loss and gliosis in the gerbil cerebral hemisphere following 30 min of unilateral common carotid artery occlusion. ( 30443768 )
2018
34
Ruptured Posterior Circulation Aneurysms with Bilateral Internal Carotid Artery Occlusion: Surgical Nuance. ( 30459858 )
2018
35
Vessel wall injury after stent retriever thrombectomy for internal carotid artery occlusion with a duplicated middle cerebral artery. ( 30529524 )
2018
36
Carotid Artery Occlusion Caused by the Judo Chokehold Technique, 'Shime-waza'. ( 28381762 )
2017
37
Internal carotid artery occlusion and stroke as a complication of cisplatin-based chemotherapy for metastatic testicular germ cell tumour. ( 28630245 )
2017
38
Cerebral Perfusion After Repair of Congenital Diaphragmatic Hernia with Common Carotid Artery Occlusion After ECMO Therapy. ( 28652420 )
2017
39
Pretemporal ("Half-and-Half") Approach for Posterior Circulation Aneurysms in a Patient With Internal Carotid Artery Occlusion. ( 28961943 )
2017
40
Trans-Anterior Communicating Artery Primary Stenting in Acute Tandem Middle Cerebral Artery-Internal Carotid Artery Occlusion Due to Thoracic Aortic Stent Graft. ( 28710049 )
2017
41
Internal Carotid Artery Occlusion in Systemic Lupus Erythematosus as a Potential Mimicker of Multiple Sclerosis. ( 28559831 )
2017
42
Collateral Assessment by CT Angiography as a Predictor of Outcome in Symptomatic Cervical Internal Carotid Artery Occlusion. ( 27765736 )
2017
43
Relay-balloon technique for recanalization of acute symptomatic proximal internal carotid artery occlusion with short balloon-tipped guiding catheter landing zone. ( 28108499 )
2017
44
Diagnostic accuracy of emergency CT angiography for presumed tandem internal carotid artery occlusion before acute endovascular therapy. ( 29101306 )
2017
45
Usefulness of contralateral carotid angiography in revascularization therapy of acute internal carotid artery occlusion. ( 28946180 )
2017
46
Rationale for graft selection in patients with complex internal carotid artery aneurysms treated with extracranial to intracranial high-flow bypass and therapeutic internal carotid artery occlusion. ( 28574313 )
2017
47
Carotid artery revascularization in patients with contralateral carotid artery occlusion: Stent or endarterectomy? ( 28666824 )
2017
48
Endovascular Revascularization of a Symptomatic Common Carotid Artery Occlusion. ( 28004633 )
2017
49
Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion. ( 29200907 )
2017
50
Posterior cerebral artery giant aneurysm associated with bilateral internal carotid artery occlusion in a Klippel-Trenaunay syndrome patient: a case report. ( 29069941 )
2017
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Variations for Carotid Artery Occlusion

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Expression for Carotid Artery Occlusion

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Search GEO for disease gene expression data for Carotid Artery Occlusion.
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Pathways for Carotid Artery Occlusion

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Pathways related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.84 APOH F5 F8 NOS3 THBD
2
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.33 F5 F8 THBD
3
Complement and coagulation cascades 1 37
10.94 F5 F8 THBD
4
Erythrocytes take up carbon dioxide and release oxygen 66
Show member pathways
 10.87 CA1 CA4
5
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
10.79 NOS3 THBD
6
Nitrogen metabolism 37
Show member pathways
 10.62 CA1 CA4
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GO Terms for Carotid Artery Occlusion

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Cellular components related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 COPII-coated ER to Golgi transport vesicle GO:0030134 8.96 F5 F8
2 cell surface GO:0009986 8.92 APOH CA4 MBP THBD

Biological processes related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.58 F5 F8 THBD
2 platelet degranulation GO:0002576 9.5 APOH F5 F8
3 bicarbonate transport GO:0015701 9.43 CA1 CA4
4 blood coagulation, intrinsic pathway GO:0007597 9.37 APOH F8
5 negative regulation of blood coagulation GO:0030195 9.26 APOH THBD
6 negative regulation of fibrinolysis GO:0051918 9.16 APOH THBD
7 negative regulation of platelet activation GO:0010544 8.96 NOS3 THBD
8 hemostasis GO:0007599 8.8 F5 F8 THBD

Molecular functions related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.13 MAP2 MBP NOS3
2 carbonate dehydratase activity GO:0004089 8.62 CA1 CA4
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Sources for Carotid Artery Occlusion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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