MCID: CRT015
MIFTS: 45

Carotid Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Artery Occlusion

MalaCards integrated aliases for Carotid Artery Occlusion:

Name: Carotid Artery Occlusion 12 6 15 71
Occlusion and Stenosis of Carotid Artery 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:807
ICD9CM 34 433.10
ICD10 32 I65.2
UMLS 71 C0265101 C0375275

Summaries for Carotid Artery Occlusion

MalaCards based summary : Carotid Artery Occlusion, also known as occlusion and stenosis of carotid artery, is related to carotid artery disease and carotid artery dissection. An important gene associated with Carotid Artery Occlusion is LDLR (Low Density Lipoprotein Receptor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Analgesics, Non-Narcotic and Fibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Carotid Artery Occlusion

Diseases related to Carotid Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 316)
# Related Disease Score Top Affiliating Genes
1 carotid artery disease 31.1 THBD PLG PLAT
2 carotid artery dissection 31.0 MYLK LDLR
3 cerebrovascular disease 30.6 THBD PLAT LDLR F8 F5 APOH
4 retinal artery occlusion 30.5 PLG F8 F5 APOH
5 transient cerebral ischemia 30.5 MAP2 IL1B HSPA1A CASP3 APOH
6 spinal cord infarction 30.5 F5 APOH
7 nonarteritic anterior ischemic optic neuropathy 30.5 NOS3 F5 APOH
8 takayasu arteritis 30.4 THBD IL1B APOH
9 vascular dementia 30.4 MBP IL1B CASP3
10 intracranial embolism 30.4 TSPAN33 PLG PLAT
11 intracranial aneurysm 30.3 PLAT NOS3 CASP3
12 pulmonary edema 30.3 NOS3 IL1B HSPA1A
13 vertebral artery occlusion 30.2 PLG PLAT
14 antithrombin iii deficiency 30.2 PLG F5 APOH
15 antiphospholipid syndrome 30.2 THBD PLAT F5 APOH
16 cerebral artery occlusion 30.2 TSPAN33 PLG NOS3 IL1B
17 cardiac tamponade 30.2 PLG PLAT F8
18 protein s deficiency 30.1 THBD F8 F5 APOH
19 retinal vascular disease 30.0 PLG NOS3 IL1B CASP3
20 factor xi deficiency 30.0 THBD F8 F5 F11
21 peripheral vascular disease 30.0 THBD PLAT NOS3 F5
22 homocystinuria 30.0 THBD F8 F5
23 intracranial hypertension 30.0 IL1B F5 APOH
24 cerebral arterial disease 29.9 TSPAN33 PLG NOS3
25 thrombophlebitis 29.9 PLG PLAT F8 F5 APOH
26 patent foramen ovale 29.9 PLG PLAT F5 APOH
27 basilar artery occlusion 29.9 TSPAN33 PLG PLAT
28 atherosclerosis susceptibility 29.8 THBD PLAT NOS3 LDLR IL1B
29 brain edema 29.8 PLAT IL1B GFAP
30 thrombophilia due to thrombin defect 29.8 THBD PLAT F8 F5 APOH
31 cerebral palsy 29.7 PLAT NOS3 IL1B F5
32 intracranial thrombosis 29.7 PLG PLAT F8 F5 APOH
33 migraine with or without aura 1 29.6 PLG NOS3 LDLR IL1B APOH
34 hydrocephalus 29.5 PLAT MBP GFAP CASP3
35 vascular disease 29.3 THBD PLG PLAT NOS3 LDLR F8
36 ischemia 29.3 PLAT NOS3 MAP2 HSPA1A GFAP CASP3
37 thrombosis 29.3 THBD PLG PLAT NOS3 F8 F5
38 myocardial infarction 27.7 THBD PLG PLAT NOS3 LDLR IL1B
39 stroke, ischemic 27.2 TSPAN33 THBD RBFOX3 PLG PLAT NOS3
40 moyamoya disease 1 11.8
41 carotid stenosis 10.8
42 aneurysm 10.6
43 amaurosis fugax 10.5
44 may-thurner syndrome 10.5 F5 APOH
45 autoimmune atherosclerosis 10.5 LDLR APOH
46 acanthamoeba keratitis 10.5 F5 APOH
47 hemiplegia 10.5
48 sudden sensorineural hearing loss 10.5 F5 APOH
49 ocular motor apraxia 10.4
50 asplenia, isolated congenital 10.4

Graphical network of the top 20 diseases related to Carotid Artery Occlusion:



Diseases related to Carotid Artery Occlusion

Symptoms & Phenotypes for Carotid Artery Occlusion

MGI Mouse Phenotypes related to Carotid Artery Occlusion:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.33 ADAMTS18 BCO1 CASP3 F11 F5 GFAP
2 homeostasis/metabolism MP:0005376 10.31 ADAMTS18 APOH BCO1 CASP3 F11 F5
3 cardiovascular system MP:0005385 10.24 CASP3 F11 F5 GFAP IL1B LDLR
4 immune system MP:0005387 10.21 ADAMTS18 CASP3 F11 F8 GFAP IL1B
5 hematopoietic system MP:0005397 10.17 CASP3 F11 F8 IL1B LDLR MBP
6 digestive/alimentary MP:0005381 10.13 ADAMTS18 CASP3 GFAP LDLR MYLK NOS3
7 mortality/aging MP:0010768 10.13 APOH CASP3 F11 F5 F8 GFAP
8 nervous system MP:0003631 9.93 CASP3 F11 F5 GFAP IL1B LDLR
9 liver/biliary system MP:0005370 9.87 BCO1 F11 F5 LDLR NOS3 PLG
10 reproductive system MP:0005389 9.61 ADAMTS18 CASP3 F8 MAP2 MBP NOS3
11 respiratory system MP:0005388 9.17 ADAMTS18 CASP3 F11 NOS3 PLAT PLG

Drugs & Therapeutics for Carotid Artery Occlusion

Drugs for Carotid Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Analgesics, Non-Narcotic Phase 3
2 Fibrinolytic Agents Phase 3
3 Purinergic P2Y Receptor Antagonists Phase 3
4 Cyclooxygenase Inhibitors Phase 3
5 Analgesics Phase 3
6 Platelet Aggregation Inhibitors Phase 3
7 Antipyretics Phase 3
8 Antirheumatic Agents Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Neurotransmitter Agents Phase 3
11 Anti-Inflammatory Agents, Non-Steroidal Phase 3
12
Ketamine Approved, Vet_approved Phase 1, Phase 2 6740-88-1 3821
13
Clopidogrel Approved Phase 1, Phase 2 113665-84-2, 120202-66-6 60606
14
Aspirin Approved, Vet_approved Phase 1, Phase 2 50-78-2 2244
15 Excitatory Amino Acid Antagonists Phase 1, Phase 2
16 Anesthetics, Dissociative Phase 1, Phase 2
17 Tissue Plasminogen Activator Phase 1, Phase 2
18 Anesthetics, General Phase 1, Phase 2
19 Plasminogen Phase 1, Phase 2
20 Anesthetics, Intravenous Phase 1, Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
2 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Active, not recruiting NCT01758614 Phase 3 Aspirin;Clopidogrel
3 Effets de la kétamine en Association Avec le Rt-PA au Cours de l'Infarctus cérébral Aigu: étude Pilote contrôlée randomisée en Double Aveugle Avec critère de Jugement Radiologique Unknown status NCT02258204 Phase 1, Phase 2 Ketamine;Placebo
4 Neurocognitive Impairment Assessment in Symptomatic Carotid Occlusion Recanalized Not yet recruiting NCT04219774 Phase 1, Phase 2 Maximal medical therapy
5 Endovascular Revascularization for Chronic Carotid Artery Occlusion Trial (ERCAO Trial) Part 1: Prospective Clinical Registry Study Part 2: Prospective Randomized Control Trial Study Unknown status NCT03179774
6 Rheolytic Thrombectomy For Adult Intraventricular Haemorrhage Unknown status NCT02394678
7 Sundt™ Carotid Shunt Retrospective Post Market Clinical Follow-up Study (PMCF) Completed NCT03816202
8 Assessment of Cerebral Circulation and Perfusion in Adults After Neonatal Carotid Occlusion Completed NCT00646672
9 Long-term Effects of Enterprise Self-expanding Intracranial Stent Implantation in the Treatment of Carotid Artery Stenosis in Patients With Ischemic Stroke: Study Protocol for a Randomized Controlled Trial Completed NCT02802072 Only aspirin medication
10 Establishment and Practice of Multi-dimensional Evaluation System for Recanalization of Symptomatic Non-acute Carotid Artery Occlusion Recruiting NCT04291430
11 Sensitivity to Acute Middle Cerebral or Intracranial Carotid Artery Occlusion in MIGrainers - SAMCO-MIG Recruiting NCT03301441
12 The Safety and Feasibility of Endovascular Revascularization of Chronically Occluded Cervical Internal Carotid Artery (COICA) Using Newly Suggested Radiographic Classification of COICA: Pilot Study Withdrawn NCT03176420

Search NIH Clinical Center for Carotid Artery Occlusion

Genetic Tests for Carotid Artery Occlusion

Anatomical Context for Carotid Artery Occlusion

MalaCards organs/tissues related to Carotid Artery Occlusion:

40
Brain, Testes, Cortex, Pituitary, Retina, Endothelial, Heart

Publications for Carotid Artery Occlusion

Articles related to Carotid Artery Occlusion:

(show top 50) (show all 3283)
# Title Authors PMID Year
1
Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1/Fyn/ROCK pathway and activating the BDNF/NRG1/PI3K pathway in rats. 61
32446949 2020
2
Roles of GABAA receptor α5 subunit on locomotion and working memory in transient forebrain ischemia in mice. 61
32428535 2020
3
3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway. 61
32377741 2020
4
Stroke and mechanical thrombectomy in patients with COVID-19: technical observations and patient characteristics. 61
32451359 2020
5
Outcome and effect of endovascular treatment in stroke associated with acute extracranial internal carotid artery occlusion: Single-center experience in Japan. 61
32376201 2020
6
Recurrent Hemispheric Stroke Syndromes in Symptomatic Atherosclerotic Internal Carotid Artery Occlusions: The Carotid Occlusion Surgery Study Randomized Trial. 61
31511891 2020
7
Integrated analysis of the proteome and transcriptome in a MCAO mouse model revealed the molecular landscape during stroke progression. 61
32181013 2020
8
The impact of single and combined PPAR-α and PPAR-γ activation on the neurological outcomes following cerebral ischemia reperfusion. 61
32325134 2020
9
Anti-mouse CX3CR1 Antibody Alleviates Cognitive Impairment, Neuronal Loss and Myelin Deficits in an Animal Model of Brain Ischemia. 61
32417340 2020
10
Occlusion of Extracranial-Intracranial Bypass Anastomosis-Associated Aneurysms Following Contralateral High-Flow Extracranial-Intracranial Bypass in a Patient with Impaired Cerebrovascular Reserve. 61
31504843 2020
11
Endovascular recanalization for symptomatic subacute and chronically occluded internal carotid artery: feasibility, safety, a modified radiographic classification system, and clinical outcomes. 61
32494963 2020
12
A Single Injection of N-Oleoyldopamine, an Endogenous Agonist for Transient Receptor Potential Vanilloid-1, Induced Brain Hypothermia, but No Neuroprotective Effects in Experimentally Induced Cerebral Ischemia in Rats. 61
31084468 2020
13
α1 adrenergic receptor activation has a dynamic effect on masticatory muscle afferent fibers. 61
32544482 2020
14
Rapid Neuronal Ultrastructure Disruption and Recovery during Spreading Depolarization-Induced Cytotoxic Edema. 61
32483593 2020
15
Acute Bilateral Internal Carotid Artery Occlusion Presenting With Symmetrical Cortical Infarctions Exhibits Dramatic Improvement After Mechanical Thrombectomy. 61
32544620 2020
16
Novel triple coaxial system to navigate 9 French balloon guiding catheter into common carotid artery. 61
32501178 2020
17
Preventive effect of silymarin-loaded chitosan nanoparticles against global cerebral ischemia/reperfusion injury in rats. 61
32171791 2020
18
Letter to the Editor regarding STA-MCA bypass via retrograde arterial anastomosis in a patient with common carotid artery occlusion: a case report. 61
32291594 2020
19
Evaluation of chronic carotid artery occlusion by non-contrast 3D-MERGE MR vessel wall imaging: comparison with 3D-TOF-MRA, contrast-enhanced MRA, and DSA. 61
32529567 2020
20
Protective Effects of Adrenomedullin on Rat Cerebral Tissue After Transient Bilateral Common Carotid Artery Occlusion and Reperfusion. 61
32549103 2020
21
Outcomes of TransCarotid Artery Revascularization (TCAR) with Dynamic Flow Reversal in Patients with Contralateral Carotid Artery Occlusion. 61
32569716 2020
22
Ablation of Vitamin D Signaling Compromises Cerebrovascular Adaptation to Carotid Artery Occlusion in Mice. 61
32545499 2020
23
Donepezil promotes neurogenesis via Src signaling pathway in a rat model of chronic cerebral hypoperfusion. 61
32184165 2020
24
Mechanical thrombectomy of right internal carotid artery terminus occlusion using the ADAPT technique: impact of aspiration on parent vessel. 61
32576702 2020
25
Collateral Recruitment Is Impaired by Cerebral Small Vessel Disease. 61
32248770 2020
26
Pattern recognition analysis of dynamic susceptibility contrast (DSC)-MRI curves automatically segments tissue areas with intact blood-brain barrier in a rat stroke model: A feasibility and comparison study. 61
31654463 2020
27
Challenges and Improvements of Developing an Ischemia Mouse Model Through Bilateral Common Carotid Artery Occlusion. 61
32199775 2020
28
Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia. 61
32489701 2020
29
Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation. 61
31913348 2020
30
Limb-shaking transient ischemic attack with facial muscles involuntary twitch successfully treated with internal carotid artery stenting. 61
32472668 2020
31
Resection of Invasive Sphenoorbital and Cavernous Sinus Meningioma via Frontotemporal Craniotomy. 61
32416238 2020
32
Carotid artery stenting before surgery for carotid artery occlusion associated with acute type A aortic dissection: Two case reports. 61
32397860 2020
33
External carotid artery stenting in symptomatic internal carotid artery occlusion. 61
32402613 2020
34
Happy heart syndrome: a case of Takotsubo syndrome with left internal carotid artery occlusion. 61
32451755 2020
35
Donepezil down-regulates propionylation, 2-hydroxyisobutyrylation, butyrylation, succinylation, and crotonylation in the brain of bilateral common carotid artery occlusion-induced vascular dementia rats. 61
32424975 2020
36
Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats. 61
32439877 2020
37
Jaw Elevation Device: Tool for Neck Immobilization to Facilitate Recovery in Endovascular Thrombectomy via Transcervical Access. 61
32437993 2020
38
Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice. 61
32084419 2020
39
Germinated Brown Rice Attenuates Cell Death in Vascular Cognitive Impaired Mice and Glutamate-Induced Toxicity In HT22 Cells. 61
32275827 2020
40
Endovascular repair of infected carotid pseudoaneurysm: A case report. 61
32535534 2020
41
Activation of 5-HT1A postsynaptic receptors by NLX-101 results in functional recovery and an increase in neuroplasticity in mice with brain ischemia. 61
31809832 2020
42
Prognosis and risk factors for reocclusion after mechanical thrombectomy. 61
32154677 2020
43
Emergency embolectomy for acute middle cerebral artery occlusion with chronic common carotid artery occlusion. 61
32055263 2020
44
Unruptured giant intracavernous aneurysms untolerate internal carotid artery occlusion test: Untreated and treated with flow-diversion. 61
31948343 2020
45
Preoperative neurological deficit in acute type A aortic dissection. 61
31958130 2020
46
Vertebral-carotid bypass for common carotid artery occlusion. 61
32336640 2020
47
Deterioration of cognitive function after transient cerebral ischemia with amyloid-β infusion-possible amelioration of cognitive function by AT2 receptor activation. 61
32264971 2020
48
Presence of Contralateral Carotid Occlusion Is Associated With Increased Periprocedural Stroke Risk Following CEA but Not CAS: A Meta-analysis and Meta-regression Analysis of 43 Studies and 96,658 Patients. 61
32066317 2020
49
Surgical procedures including carotid-carotid crossover bypass and ring-stripping hybrid operation for Rile's type 1A common carotid artery occlusion: an experience of 6 cases. 61
32395483 2020
50
Lymphocytic Hypophysitis Presenting as Bilateral Abducens Nerve Palsy: A Case Report. 61
32395162 2020

Variations for Carotid Artery Occlusion

ClinVar genetic disease variations for Carotid Artery Occlusion:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 LDLR NM_000527.5(LDLR):c.682G>A (p.Glu228Lys)SNV Pathogenic/Likely pathogenic 3691 rs121908029 19:11216264-11216264 19:11105588-11105588
2 MYLK NM_053025.4(MYLK):c.2149G>A (p.Asp717Asn)SNV Uncertain significance 519975 rs150936840 3:123426842-123426842 3:123707995-123707995

Expression for Carotid Artery Occlusion

Search GEO for disease gene expression data for Carotid Artery Occlusion.

Pathways for Carotid Artery Occlusion

Pathways related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 THBD PLG PLAT NOS3 F8 F5
2
Show member pathways
12.11 PLG PLAT LDLR IL1B
3
Show member pathways
12.03 LDLR IL1B HSPA1A CASP3
4
Show member pathways
12.03 MBP MAP2 LDLR CASP3
5 11.81 THBD PLAT NOS3 IL1B
6 11.7 MBP IL1B GFAP CASP3
7
Show member pathways
11.63 THBD PLG PLAT F8 F5 F11
8 11.46 THBD NOS3 IL1B CASP3
9 11.36 IL1B HSPA1A CASP3
10 11.26 THBD PLG PLAT F8 F5 F11
11 10.61 PLG PLAT

GO Terms for Carotid Artery Occlusion

Cellular components related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 THBD PLG PLAT IL1B F8 F5
2 extracellular region GO:0005576 9.81 PLG PLAT IL1B HSPA1A F8 F5
3 cell surface GO:0009986 9.17 TSPAN33 THBD PLG PLAT MBP LDLR
4 platelet alpha granule lumen GO:0031093 9.13 PLG F8 F5

Biological processes related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.78 THBD NOS3 IL1B CASP3
2 platelet degranulation GO:0002576 9.67 PLG F8 F5 APOH
3 cellular response to organic substance GO:0071310 9.58 MAP2 IL1B CASP3
4 negative regulation of blood coagulation GO:0030195 9.52 THBD APOH
5 regulation of blood coagulation GO:0030193 9.51 F11 APOH
6 blood coagulation, intrinsic pathway GO:0007597 9.5 F8 F11 APOH
7 negative regulation of platelet activation GO:0010544 9.49 THBD NOS3
8 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.46 PLG PLAT
9 positive regulation of fibrinolysis GO:0051919 9.43 PLG F11
10 plasminogen activation GO:0031639 9.43 PLAT F11 APOH
11 blood coagulation GO:0007596 9.43 THBD PLG PLAT F8 F5 F11
12 negative regulation of fibrinolysis GO:0051918 9.33 THBD PLG APOH
13 hemostasis GO:0007599 9.02 THBD PLG F8 F5 F11

Molecular functions related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.35 PLG PLAT F11 CASP3 ADAMTS18
2 protease binding GO:0002020 9.33 MBP LDLR CASP3
3 calmodulin binding GO:0005516 8.92 NOS3 MYLK MBP MAP2

Sources for Carotid Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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