MCID: CRT015
MIFTS: 44

Carotid Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Artery Occlusion

MalaCards integrated aliases for Carotid Artery Occlusion:

Name: Carotid Artery Occlusion 12 6 15 72
Occlusion and Stenosis of Carotid Artery 12 33

Classifications:



External Ids:

Disease Ontology 12 DOID:807
ICD9CM 35 433.10
ICD10 33 I65.2
UMLS 72 C0265101 C0375275

Summaries for Carotid Artery Occlusion

MalaCards based summary : Carotid Artery Occlusion, also known as occlusion and stenosis of carotid artery, is related to retinal artery occlusion and spinal cord infarction. An important gene associated with Carotid Artery Occlusion is LDLR (Low Density Lipoprotein Receptor), and among its related pathways/superpathways are Toxoplasmosis and Formation of Fibrin Clot (Clotting Cascade). The drugs Clopidogrel and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Carotid Artery Occlusion

Diseases related to Carotid Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 retinal artery occlusion 30.6 F8 F5 APOH
2 spinal cord infarction 30.6 F5 APOH
3 transient cerebral ischemia 30.5 MAP2 HSPA1A CASP3 APOH
4 antithrombin iii deficiency 30.3 F5 APOH
5 thrombophlebitis 30.3 F8 F5 APOH
6 antiphospholipid syndrome 30.2 THBD F5 APOH
7 intracranial thrombosis 30.1 F8 F5 APOH
8 ischemia 30.0 NOS3 MAP2 HSPA1A CASP3
9 vascular disease 30.0 THBD NOS3 LDLR F5 APOH
10 thrombosis 29.9 THBD F8 F5 APOH
11 dysfibrinogenemia 29.9 THBD F5
12 protein s deficiency 29.5 F5 APOH
13 thrombophilia due to thrombin defect 29.5 THBD F8 F5 APOH
14 myocardial infarction 28.5 THBD NOS3 LDLR F8 F5 CASP3
15 stroke, ischemic 27.9 THBD NOS3 MBP MAP2 F5 CASP3
16 moyamoya disease 1 11.8
17 carotid stenosis 10.8
18 aneurysm 10.6
19 carotid artery disease 10.6
20 cerebrovascular disease 10.6
21 amaurosis fugax 10.5
22 may-thurner syndrome 10.5 F5 APOH
23 acanthamoeba keratitis 10.5 F5 APOH
24 sudden sensorineural hearing loss 10.5 F5 APOH
25 cerebral sinovenous thrombosis 10.5 F5 APOH
26 pregnancy loss, recurrent 1 10.5 F5 APOH
27 acquired hemophilia 10.5 F8 F5
28 prothrombin deficiency, congenital 10.5 F5 APOH
29 acquired hemophilia a 10.5 F8 F5
30 ischemic colitis 10.5 F5 APOH
31 hemophilia a 10.5 F8 F5
32 catastrophic antiphospholipid syndrome 10.5 F5 APOH
33 hemiplegia 10.5
34 priapism 10.5 NOS3 F5
35 factor v and factor viii, combined deficiency of, 2 10.4 F8 F5
36 asplenia, isolated congenital 10.4
37 retinal vascular occlusion 10.4 F5 APOH
38 factor viii deficiency 10.4 F8 F5
39 ocular motor apraxia 10.4
40 aphasia 10.4
41 livedoid vasculitis 10.4 F8 APOH
42 yemenite deaf-blind hypopigmentation syndrome 10.4
43 cerebral aneurysms 10.4
44 chronic enteropathy associated with slco2a1 gene 10.4
45 peripheral vertigo 10.4 F5 APOH
46 factor xiii deficiency 10.4 F8 F5
47 meningococcemia 10.4 THBD F5
48 raynaud phenomenon 10.4 THBD APOH
49 buerger disease 10.3 NOS3 APOH
50 central retinal vein occlusion 10.3 F5 APOH

Graphical network of the top 20 diseases related to Carotid Artery Occlusion:



Diseases related to Carotid Artery Occlusion

Symptoms & Phenotypes for Carotid Artery Occlusion

MGI Mouse Phenotypes related to Carotid Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.06 ADAMTS18 BCO1 CA4 CASP3 F5 LDLR
2 homeostasis/metabolism MP:0005376 10.03 ADAMTS18 APOH BCO1 CA4 CASP3 F5
3 digestive/alimentary MP:0005381 9.85 ADAMTS18 CASP3 LDLR MYLK NOS3 THBD
4 immune system MP:0005387 9.76 ADAMTS18 CASP3 F8 LDLR MBP MYLK
5 mortality/aging MP:0010768 9.7 APOH CA4 CASP3 F5 F8 LDLR
6 reproductive system MP:0005389 9.23 ADAMTS18 CA4 CASP3 F8 MAP2 MBP

Drugs & Therapeutics for Carotid Artery Occlusion

Drugs for Carotid Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
2 Neurotransmitter Agents Phase 3
3 Purinergic P2Y Receptor Antagonists Phase 3
4 Purinergic P2 Receptor Antagonists Phase 3
5
Ketamine Approved, Vet_approved Phase 1, Phase 2 6740-88-1 3821
6 Tissue Plasminogen Activator Phase 1, Phase 2
7 Excitatory Amino Acid Antagonists Phase 1, Phase 2
8 Anesthetics, General Phase 1, Phase 2
9 Anesthetics, Dissociative Phase 1, Phase 2
10 Central Nervous System Depressants Phase 1, Phase 2
11 Plasminogen Phase 1, Phase 2
12 Anesthetics, Intravenous Phase 1, Phase 2
13 Excitatory Amino Acids Phase 1, Phase 2
14
Aspirin Approved, Vet_approved 50-78-2 2244
15 Analgesics
16 Analgesics, Non-Narcotic
17 Cyclooxygenase Inhibitors
18 Fibrinolytic Agents
19 Anti-Inflammatory Agents, Non-Steroidal
20 Peripheral Nervous System Agents
21 Platelet Aggregation Inhibitors
22 Anti-Inflammatory Agents
23 Antipyretics
24 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
2 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
3 Effets de la kétamine en Association Avec le Rt-PA au Cours de l'Infarctus cérébral Aigu: étude Pilote contrôlée randomisée en Double Aveugle Avec critère de Jugement Radiologique Unknown status NCT02258204 Phase 1, Phase 2 Ketamine;Placebo
4 Rheolytic Thrombectomy For Adult Intraventricular Haemorrhage Unknown status NCT02394678
5 Assessment of Cerebral Circulation and Perfusion in Adults After Neonatal Carotid Occlusion Completed NCT00646672
6 Long-term Effects of Enterprise Self-expanding Intracranial Stent Implantation in the Treatment of Carotid Artery Stenosis in Patients With Ischemic Stroke: Study Protocol for a Randomized Controlled Trial Completed NCT02802072 Only aspirin medication
7 Sundt™ Carotid Shunt Retrospective Post Market Clinical Follow-up Study (PMCF) Recruiting NCT03816202
8 Endovascular Revascularization for Chronic Carotid Artery Occlusion Trial (ERCAO Trial) Part 1: Prospective Clinical Registry Study Part 2: Prospective Randomized Control Trial Study Recruiting NCT03179774
9 Sensitivity to Acute Middle Cerebral or Intracranial Carotid Artery Occlusion in MIGrainers - SAMCO-MIG Recruiting NCT03301441
10 The Safety and Feasibility of Endovascular Revascularization of Chronically Occluded Cervical Internal Carotid Artery (COICA) Using Newly Suggested Radiographic Classification of COICA: Pilot Study Withdrawn NCT03176420

Search NIH Clinical Center for Carotid Artery Occlusion

Genetic Tests for Carotid Artery Occlusion

Anatomical Context for Carotid Artery Occlusion

MalaCards organs/tissues related to Carotid Artery Occlusion:

41
Brain, Testes, Cortex, Pituitary, Retina, Endothelial, Heart

Publications for Carotid Artery Occlusion

Articles related to Carotid Artery Occlusion:

(show top 50) (show all 3147)
# Title Authors PMID Year
1
Investigation of the protective effect of heparin pre-treatment on cerebral ischaemia in gerbils. 38
31401926 2019
2
Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. 38
31238056 2019
3
Protective Effect of Cholic Acid-Coated Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Loaded with Erythropoietin on Experimental Stroke. 38
31026988 2019
4
Cardiac surgery in the presence of chronic internal carotid artery occlusion. 38
30904987 2019
5
Revascularization for Cerebral Ischemia, Step-by-Step Demonstration of Bonnet Bypass: 3-Dimensional Operative Video. 38
30690494 2019
6
Quantitative measurement of regional cerebral blood flow and oxygen metabolism in a rat model of cerebral hypoperfusion. 38
31132338 2019
7
Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice. 38
31406177 2019
8
Central Retinal Artery Occlusion Associated with Carotid Artery Occlusion. 38
31403098 2019
9
Topically applied adipose-derived mesenchymal stem cell treatment in experimental focal cerebral ischemia. 38
31431402 2019
10
Neuroprotective effects of neurotropin in a mouse model of hypoxic-ischemic brain injury. 38
31115666 2019
11
Bypass strategies for common carotid artery occlusion. 38
31377956 2019
12
Four collateral circulation pathways were observed after common carotid artery occlusion. 38
31429719 2019
13
Cerebroprotective Potential of Hesperidin Nanoparticles Against Bilateral Common Carotid Artery Occlusion Reperfusion Injury in Rats and In silico Approaches. 38
31422568 2019
14
Added assessment of middle cerebral artery and atrial fibrillation to FLAIR vascular hyperintensity-DWI mismatch would improve the outcome prediction of acute infarction in patients with acute internal carotid artery occlusion. 38
31392639 2019
15
Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia. 38
30964065 2019
16
Thrombus Imaging Characteristics and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment. 38
31216961 2019
17
Beyond the collaterals: Additional value of multiphase CTA in acute ischemic stroke evaluation. 38
31018761 2019
18
A Case of Juvenile Stroke due to Carotid Artery Dissection from an Elongated Styloid Process-Revisiting Conservative Management. 38
31383620 2019
19
Triptolide Improves Cognitive Dysfunction in Rats with Vascular Dementia by Activating the SIRT1/PGC-1α Signaling Pathway. 38
31236795 2019
20
Arundic acid administration protects astrocytes, recovers histological damage and memory deficits induced by neonatal hypoxia ischemia in rats. 38
31202867 2019
21
Addressing the alterations in cerebral ischemia-reperfusion injury on the brain mitochondrial activity: A possible link to cognitive decline. 38
31405561 2019
22
Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet. 38
29350576 2019
23
Internal carotid artery occlusion may affect long-term quality of life in patients with high-flow carotid cavernous fistulas. 38
31333051 2019
24
Alterations in Retinal Oxygen Delivery, Metabolism, and Extraction Fraction During Bilateral Common Carotid Artery Occlusion in Rats. 38
31343655 2019
25
Molecular Alterations and Effects of Acute Dehydroepiandrosterone Treatment Following Brief Bilateral Common Carotid Artery Occlusion: Relevance to Transient Ischemic Attack. 38
31095985 2019
26
Superficial Temporal Artery Trunk-to-Middle Cerebral Artery Bypass with Short Radial Artery Interposition Graft for Symptomatic Internal Carotid Artery Occlusion. 38
30898742 2019
27
Pencil Beam Presaturation Magnetic Resonance Imaging Helps to Identify Patients at Risk for Intolerance to Temporary Internal Carotid Artery Occlusion During Carotid Endarterectomy and Carotid Artery Stenting. 38
31301443 2019
28
Outcomes of Endovascular Thrombectomy Performed 6-24 h after Acute Stroke from Extracranial Internal Carotid Artery Occlusion. 38
31281169 2019
29
Re Alarming Results for Carotid Artery Stenting in Patients with Contralateral Carotid Artery Occlusion. 38
31371143 2019
30
Rapid Alterations in Cerebral White Matter Lipid Profiles After Ischemic-Reperfusion Brain Injury in Fetal Sheep as Demonstrated by MALDI-Mass Spectrometry. 38
30683019 2019
31
Retinoprotective Effects of TAT-Bound Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase Activating Polypeptide. 38
30542799 2019
32
The protective effect of persistent trigeminal artery in patients with ischemic stroke. 38
31296184 2019
33
Acute thromboses and occlusions of dual layer carotid stents in endovascular treatment of tandem occlusions. 38
31308199 2019
34
Probiotic supplementation attenuates hippocampus injury and spatial learning and memory impairments in a cerebral hypoperfusion mouse model. 38
31286392 2019
35
Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion. 38
31103857 2019
36
MicroRNA-132 regulates total protein of Nav1.1 and Nav1.2 in the hippocampus and cortex of rat with chronic cerebral hypoperfusion. 38
30885820 2019
37
Effect of Pei Yuan Tong Nao capsules on neuronal function and metabolism in cerebral ischemic rats. 38
30926568 2019
38
Analysis of the ROADSTER pivotal and extended-access cohorts shows excellent 1-year durability of transcarotid stenting with dynamic flow reversal. 38
30611582 2019
39
[Effect of Ghrelin on Memory Impairment in a Rat Model of Vascular Dementia]. 38
31266928 2019
40
Stroke in Association with Thyroid Goitre: A Case Report. 38
30935806 2019
41
Intravenous Milrinone Salvage Therapy in Acute Internal Carotid Artery Occlusion: Case Report. 38
30661227 2019
42
Neuroprotection of cordycepin in NMDA-induced excitotoxicity by modulating adenosine A1 receptors. 38
30978320 2019
43
Fluctuating patency of atherosclerotic cervical internal carotid artery treated by carotid endarterectomy successfully: a case report. 38
31204515 2019
44
Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion. 38
30826297 2019
45
Chrysin prevents cognitive and hippocampal long-term potentiation deficits and inflammation in rat with cerebral hypoperfusion and reperfusion injury. 38
30991061 2019
46
Recanalization of Acute Common Carotid Artery Occlusion: 2-Dimensional Operative Video. 38
30099507 2019
47
Commentary: Recanalization of Acute Common Carotid Artery Occlusion: 2-Dimensional Operative Video. 38
30247669 2019
48
[Management of extracranial carotid artery aneurysm]. 38
31104503 2019
49
Resveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion. 38
31052460 2019
50
Association of Concomitant Intracranial Atherosclerotic Stenosis with Collateral Status in Patients with Emergent Large Vessel Occlusion. 38
31103756 2019

Variations for Carotid Artery Occlusion

ClinVar genetic disease variations for Carotid Artery Occlusion:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 LDLR NM_000527.4(LDLR): c.682G> A (p.Glu228Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121908029 19:11216264-11216264 19:11105588-11105588
2 MYLK NM_053025.4(MYLK): c.2149G> A (p.Asp717Asn) single nucleotide variant Uncertain significance rs150936840 3:123426842-123426842 3:123707995-123707995

Expression for Carotid Artery Occlusion

Search GEO for disease gene expression data for Carotid Artery Occlusion.

Pathways for Carotid Artery Occlusion

GO Terms for Carotid Artery Occlusion

Cellular components related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 THBD MBP LDLR CA4 APOH

Biological processes related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.63 THBD F8 F5
2 response to lipopolysaccharide GO:0032496 9.61 THBD NOS3 CASP3
3 platelet degranulation GO:0002576 9.5 F8 F5 APOH
4 response to X-ray GO:0010165 9.4 THBD CASP3
5 blood coagulation, intrinsic pathway GO:0007597 9.37 F8 APOH
6 negative regulation of blood coagulation GO:0030195 9.26 THBD APOH
7 negative regulation of fibrinolysis GO:0051918 9.16 THBD APOH
8 negative regulation of platelet activation GO:0010544 8.96 THBD NOS3
9 hemostasis GO:0007599 8.8 THBD F8 F5

Molecular functions related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 MBP LDLR CASP3
2 calmodulin binding GO:0005516 8.92 NOS3 MYLK MBP MAP2

Sources for Carotid Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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