MCID: CRT015
MIFTS: 44

Carotid Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Artery Occlusion

MalaCards integrated aliases for Carotid Artery Occlusion:

Name: Carotid Artery Occlusion 12 6 15 71
Occlusion and Stenosis of Carotid Artery 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:807
ICD9CM 34 433.10
ICD10 32 I65.2
UMLS 71 C0265101 C0375275

Summaries for Carotid Artery Occlusion

MalaCards based summary : Carotid Artery Occlusion, also known as occlusion and stenosis of carotid artery, is related to carotid artery disease and carotid artery dissection. An important gene associated with Carotid Artery Occlusion is LDLR (Low Density Lipoprotein Receptor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and G-protein signaling Ras family GTPases in kinase cascades (scheme). The drugs Clopidogrel and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and testes, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Carotid Artery Occlusion

Diseases related to Carotid Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
# Related Disease Score Top Affiliating Genes
1 carotid artery disease 31.2 THBD PLG PLAT
2 carotid artery dissection 31.1 MYLK LDLR
3 transient cerebral ischemia 31.0 MAP2 HSPA1A CASP3 APOH
4 intracranial embolism 30.6 PLG PLAT
5 cerebrovascular disease 30.6 THBD PLAT LDLR F8 F5 APOH
6 retinal artery occlusion 30.5 PLG F8 F5 APOH
7 spinal cord infarction 30.5 F5 APOH
8 retinal vascular disease 30.5 PLG NOS3 CASP3
9 intracranial aneurysm 30.3 PLAT NOS3 CASP3
10 antithrombin iii deficiency 30.2 PLG F5 APOH
11 antiphospholipid syndrome 30.2 THBD PLAT F5 APOH
12 protein s deficiency 30.1 THBD F8 F5 APOH
13 ischemia 30.1 PLAT NOS3 MAP2 HSPA1A CASP3
14 atherosclerosis susceptibility 30.0 THBD PLAT NOS3 LDLR
15 basilar artery occlusion 30.0 TSPAN33 PLG PLAT
16 peripheral vascular disease 30.0 THBD PLAT NOS3 F5
17 migraine with or without aura 1 30.0 PLG NOS3 LDLR APOH
18 carotid artery thrombosis 30.0 PLG PLAT NOS3 CIART
19 central retinal artery occlusion 30.0 PLG PLAT
20 thrombophlebitis 29.9 PLG PLAT F8 F5 APOH
21 factor xi deficiency 29.8 THBD F8 F5 F11
22 patent foramen ovale 29.8 PLG PLAT F5 APOH
23 cerebral arterial disease 29.8 TSPAN33 PLG PLAT NOS3
24 thrombophilia due to thrombin defect 29.7 THBD PLAT F8 F5 APOH
25 vascular disease 29.3 THBD PLG PLAT NOS3 LDLR F8
26 intracranial thrombosis 29.1 PLG PLAT F8 F5 CIART APOH
27 thrombosis 29.1 THBD PLG PLAT NOS3 F8 F5
28 myocardial infarction 28.3 THBD PLG PLAT NOS3 LDLR F8
29 stroke, ischemic 27.9 TSPAN33 THBD RBFOX3 PLG PLAT NOS3
30 moyamoya disease 1 11.8
31 carotid stenosis 10.8
32 aneurysm 10.6
33 amaurosis fugax 10.5
34 autoimmune atherosclerosis 10.5 LDLR APOH
35 may-thurner syndrome 10.5 F5 APOH
36 acanthamoeba keratitis 10.5 F5 APOH
37 sudden sensorineural hearing loss 10.5 F5 APOH
38 hemiplegia 10.5
39 asplenia, isolated congenital 10.4
40 factor v and factor viii, combined deficiency of, 2 10.4 F8 F5
41 catastrophic antiphospholipid syndrome 10.4 F5 APOH
42 mercury poisoning 10.4 THBD PLAT
43 ocular motor apraxia 10.4
44 yemenite deaf-blind hypopigmentation syndrome 10.4
45 aphasia 10.4
46 prothrombin deficiency, congenital 10.4 F5 APOH
47 cerebral aneurysms 10.4
48 chronic enteropathy associated with slco2a1 gene 10.4
49 cerebral sinovenous thrombosis 10.4 F5 APOH
50 meningococcemia 10.4 THBD F5

Graphical network of the top 20 diseases related to Carotid Artery Occlusion:



Diseases related to Carotid Artery Occlusion

Symptoms & Phenotypes for Carotid Artery Occlusion

MGI Mouse Phenotypes related to Carotid Artery Occlusion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 ADAMTS18 APOH BCO1 CA4 CASP3 CIART
2 growth/size/body region MP:0005378 10.28 ADAMTS18 BCO1 CA4 CASP3 F11 F5
3 immune system MP:0005387 10.15 ADAMTS18 CASP3 F11 F8 LDLR MBP
4 mortality/aging MP:0010768 10.13 APOH CA4 CASP3 CIART F11 F5
5 digestive/alimentary MP:0005381 10.06 ADAMTS18 CASP3 LDLR MYLK NOS3 PLAT
6 liver/biliary system MP:0005370 9.87 BCO1 F11 F5 LDLR NOS3 PLG
7 reproductive system MP:0005389 9.85 ADAMTS18 CA4 CASP3 F8 MAP2 MBP
8 respiratory system MP:0005388 9.5 ADAMTS18 CASP3 F11 NOS3 PLAT PLG
9 vision/eye MP:0005391 9.23 ADAMTS18 CA4 CASP3 LDLR MBP NOS3

Drugs & Therapeutics for Carotid Artery Occlusion

Drugs for Carotid Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
2 Neurotransmitter Agents Phase 3
3 Purinergic P2Y Receptor Antagonists Phase 3
4
Ketamine Approved, Vet_approved Phase 1, Phase 2 6740-88-1 3821
5 Plasminogen Phase 1, Phase 2
6 Anesthetics, Dissociative Phase 1, Phase 2
7 Anesthetics, General Phase 1, Phase 2
8 Tissue Plasminogen Activator Phase 1, Phase 2
9 Anesthetics, Intravenous Phase 1, Phase 2
10 Central Nervous System Depressants Phase 1, Phase 2
11 Excitatory Amino Acid Antagonists Phase 1, Phase 2
12 Excitatory Amino Acids Phase 1, Phase 2
13
Aspirin Approved, Vet_approved 50-78-2 2244
14 Anti-Inflammatory Agents
15 Fibrinolytic Agents
16 Antipyretics
17 Anti-Inflammatory Agents, Non-Steroidal
18 Platelet Aggregation Inhibitors
19 Analgesics, Non-Narcotic
20 Cyclooxygenase Inhibitors
21 Antirheumatic Agents
22 Analgesics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
2 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
3 Effets de la kétamine en Association Avec le Rt-PA au Cours de l'Infarctus cérébral Aigu: étude Pilote contrôlée randomisée en Double Aveugle Avec critère de Jugement Radiologique Unknown status NCT02258204 Phase 1, Phase 2 Ketamine;Placebo
4 Rheolytic Thrombectomy For Adult Intraventricular Haemorrhage Unknown status NCT02394678
5 Assessment of Cerebral Circulation and Perfusion in Adults After Neonatal Carotid Occlusion Completed NCT00646672
6 Long-term Effects of Enterprise Self-expanding Intracranial Stent Implantation in the Treatment of Carotid Artery Stenosis in Patients With Ischemic Stroke: Study Protocol for a Randomized Controlled Trial Completed NCT02802072 Only aspirin medication
7 Sundt™ Carotid Shunt Retrospective Post Market Clinical Follow-up Study (PMCF) Recruiting NCT03816202
8 Endovascular Revascularization for Chronic Carotid Artery Occlusion Trial (ERCAO Trial) Part 1: Prospective Clinical Registry Study Part 2: Prospective Randomized Control Trial Study Recruiting NCT03179774
9 Sensitivity to Acute Middle Cerebral or Intracranial Carotid Artery Occlusion in MIGrainers - SAMCO-MIG Recruiting NCT03301441
10 The Safety and Feasibility of Endovascular Revascularization of Chronically Occluded Cervical Internal Carotid Artery (COICA) Using Newly Suggested Radiographic Classification of COICA: Pilot Study Withdrawn NCT03176420

Search NIH Clinical Center for Carotid Artery Occlusion

Genetic Tests for Carotid Artery Occlusion

Anatomical Context for Carotid Artery Occlusion

MalaCards organs/tissues related to Carotid Artery Occlusion:

40
Brain, Pituitary, Testes, Cortex, Heart, Retina, Endothelial

Publications for Carotid Artery Occlusion

Articles related to Carotid Artery Occlusion:

(show top 50) (show all 3211)
# Title Authors PMID Year
1
Cerebroprotective Potential of Hesperidin Nanoparticles Against Bilateral Common Carotid Artery Occlusion Reperfusion Injury in Rats and In silico Approaches. 61
31422568 2020
2
On the anatomical definition of arterial networks in blood flow simulations: comparison of detailed and simplified models. 61
32034549 2020
3
Cerebral Lipid Dynamics in Chronic Cerebral Hypoperfusion Model by DESI-MS Imaging. 61
31785353 2020
4
Protection of blood-brain barrier as a potential mechanism for enriched environments to improve cognitive impairment caused by chronic cerebral hypoperfusion. 61
31778736 2020
5
Carotid Artery Stenting and Intracranial Thrombectomy for Tandem Cervical and Intracranial Artery Occlusions. 61
30848283 2020
6
Neuroimaging in Ischemic Stroke Is Different Between Men and Women in the DEFUSE 3 Cohort. 61
31826731 2020
7
Silencing of long noncoding RNA XIST attenuated Alzheimer's disease-related BACE1 alteration through miR-124. 61
31743528 2020
8
Internal carotid artery occlusion may affect long-term quality of life in patients with high-flow carotid cavernous fistulas. 61
31333051 2020
9
Balanced single-vector co-delivery of VEGF/PDGF-BB improves functional collateralization in chronic cerebral ischemia. 61
30621518 2020
10
Superficial temporal artery to middle cerebral artery (STA-MCA) bypass via retrograde arterial anastomosis in a patient with common carotid artery occlusion: a case report. 61
31748902 2020
11
Evaluation of Balloon Test Occlusion Before Therapeutic Carotid Artery Occlusion: Flat Detector Computed Tomography Cerebral Blood Volume Imaging versus Single-Photon Emission Computed Tomography. 61
31550537 2020
12
Emergent carotid artery stenting in patients with acute ischemic stroke due to cervical internal carotid artery steno-occlusive lesion: Comparison of tandem intracranial occlusion and isolated cervical internal carotid artery occlusion. 61
31992107 2020
13
Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion. 61
31903107 2020
14
Acute thromboses and occlusions of dual layer carotid stents in endovascular treatment of tandem occlusions. 61
31308199 2020
15
Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43. 61
31908570 2020
16
Cerebral collaterals and stroke in patients with isolated carotid artery dissections. 61
31937504 2020
17
Neuroprotective potential of azilsartan against cerebral ischemic injury: Possible involvement of mitochondrial mechanisms. 61
31751621 2020
18
TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus. 61
31900229 2020
19
Effect of endogenous sulfur dioxide on spatial learning and memory and hippocampal damages in the experimental model of chronic cerebral hypoperfusion. 61
32004146 2020
20
The Involvement of Canonical Wnt Signaling in Memory Impairment Induced by Chronic Cerebral Hypoperfusion in Mice. 61
31960287 2020
21
Wuzang Wenyang Huayu decoction regulates differentially expressed transcripts in the rats' hippocampus after cerebral hypoperfusion. 61
31705584 2020
22
Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation. 61
31913348 2020
23
[Case report: transient ischemic stroke caused by internal carotid artery occlusion due to compression by pituitary apoplexy and hemodynamic mechanism]. 61
31956196 2020
24
A Successful Treatment Strategy for Paradoxical Cerebral Embolism Accompanied by Entrapped Thrombus in Patent Foramen Ovale. 61
31484914 2020
25
Topically applied adipose-derived mesenchymal stem cell treatment in experimental focal cerebral ischemia. 61
31431402 2020
26
Mode of action of granulocyte-colony stimulating factor (G-CSF) as a novel therapy for stroke in a mouse model. 61
31907023 2020
27
Preoperative neurological deficit in acute type A aortic dissection. 61
31958130 2020
28
Unruptured giant intracavernous aneurysms untolerate internal carotid artery occlusion test: Untreated and treated with flow-diversion. 61
31948343 2020
29
Two cases of symptomatic common carotid artery occlusion treated by carotid endarterectomy with L-shaped ministernotomy. 61
31966920 2020
30
Added assessment of middle cerebral artery and atrial fibrillation to FLAIR vascular hyperintensity-DWI mismatch would improve the outcome prediction of acute infarction in patients with acute internal carotid artery occlusion. 61
31392639 2019
31
Comparison of postoperative results between carotid endarterectomy and carotid artery stenting for patients with contralateral carotid artery occlusion: A meta-analysis. 61
31027468 2019
32
Unilateral Pulsus Parvus et Tardus Waveform Discovered during Carotid Artery Doppler Examination: a Clue of Proximal Carotid Artery Occlusion. 61
31760708 2019
33
Collateral grade of the Willis' circle predicts outcomes of acute intracranial internal carotid artery occlusion before thrombectomy. 61
31696661 2019
34
The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling. 61
31808139 2019
35
URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion. 61
31815636 2019
36
Investigation of the protective effect of heparin pre-treatment on cerebral ischaemia in gerbils. 61
31401926 2019
37
Activation of 5-HT1A postsynaptic receptors by NLX-101 results in functional recovery and an increase in neuroplasticity in mice with brain ischemia. 61
31809832 2019
38
Neuroprotective effects of clavulanic acid following permanent bilateral common carotid artery occlusion in rats. 61
31482584 2019
39
Nonfocal Transient Neurological Attacks Are Associated With Cerebral Small Vessel Disease. 61
31637974 2019
40
Long-term outcomes of axillary to carotid bypass for symptomatic patients with chronic common carotid artery occlusion. 61
31882308 2019
41
Neuroprotective effects of irisin against cerebral ischemia/ reperfusion injury via Notch signaling pathway. 61
31561067 2019
42
Early versus Delayed Extracranial-Intracranial Bypass Surgery in Symptomatic Atherosclerotic Occlusion. 61
30239897 2019
43
New endovascular perforation subarachnoid hemorrhage model for investigating the mechanisms of delayed brain injury. 61
31756704 2019
44
[A Case Report of Endovascular Thrombectomy for Internal Carotid Artery Thromboembolism after Left Upper Lobectomy of Lung Cancer]. 61
31761777 2019
45
Gastrodin Alleviates Vascular Dementia in a 2-VO-Vascular Dementia Rat Model by Altering Amyloid and Tau Levels. 61
31752010 2019
46
Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway. 61
31542426 2019
47
Effects of resveratrol on learning and memory in rats with vascular dementia. 61
31702039 2019
48
[Advantages and Disadvantages of Carotid Endarterectomy and Carotid Artery Stenting:Notes from a Hybrid Neurosurgeon]. 61
31761776 2019
49
[Differences of brain pathological changes and cognitive function after bilateral common carotid artery occlusion between Sprague-Dawley and Wistar rats]. 61
31646324 2019
50
Pencil Beam Presaturation Magnetic Resonance Imaging Helps to Identify Patients at Risk for Intolerance to Temporary Internal Carotid Artery Occlusion During Carotid Endarterectomy and Carotid Artery Stenting. 61
31301443 2019

Variations for Carotid Artery Occlusion

ClinVar genetic disease variations for Carotid Artery Occlusion:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 LDLR NM_000527.4(LDLR):c.682G>A (p.Glu228Lys)SNV Pathogenic/Likely pathogenic 3691 rs121908029 19:11216264-11216264 19:11105588-11105588
2 MYLK NM_053025.4(MYLK):c.2149G>A (p.Asp717Asn)SNV Uncertain significance 519975 rs150936840 3:123426842-123426842 3:123707995-123707995

Expression for Carotid Artery Occlusion

Search GEO for disease gene expression data for Carotid Artery Occlusion.

Pathways for Carotid Artery Occlusion

GO Terms for Carotid Artery Occlusion

Cellular components related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 TSPAN33 THBD PLG NOS3 MYLK MBP
2 cell surface GO:0009986 9.23 TSPAN33 THBD PLG PLAT MBP LDLR
3 platelet alpha granule lumen GO:0031093 9.13 PLG F8 F5

Biological processes related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.67 PLG F8 F5 APOH
2 blood coagulation, intrinsic pathway GO:0007597 9.5 F8 F11 APOH
3 negative regulation of blood coagulation GO:0030195 9.49 THBD APOH
4 regulation of blood coagulation GO:0030193 9.48 F11 APOH
5 negative regulation of platelet activation GO:0010544 9.46 THBD NOS3
6 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.43 PLG PLAT
7 plasminogen activation GO:0031639 9.43 PLAT F11 APOH
8 blood coagulation GO:0007596 9.43 THBD PLG PLAT F8 F5 F11
9 positive regulation of fibrinolysis GO:0051919 9.4 PLG F11
10 negative regulation of fibrinolysis GO:0051918 9.33 THBD PLG APOH
11 hemostasis GO:0007599 9.02 THBD PLG F8 F5 F11

Molecular functions related to Carotid Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.19 TSPAN33 THBD PLG PLAT NOS3 MYLK
2 peptidase activity GO:0008233 9.35 PLG PLAT F11 CASP3 ADAMTS18
3 protease binding GO:0002020 9.33 MBP LDLR CASP3
4 calmodulin binding GO:0005516 8.92 NOS3 MYLK MBP MAP2

Sources for Carotid Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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