MCID: CRT004
MIFTS: 37

Carotid Artery Thrombosis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Carotid Artery Thrombosis

MalaCards integrated aliases for Carotid Artery Thrombosis:

Name: Carotid Artery Thrombosis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3410
MeSH 45 D002341
SNOMED-CT 69 86003009
UMLS 74 C0007274

Summaries for Carotid Artery Thrombosis

MalaCards based summary : Carotid Artery Thrombosis is related to thrombosis and mucormycosis. An important gene associated with Carotid Artery Thrombosis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include brain, liver and endothelial, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Carotid Artery Thrombosis

Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 thrombosis 31.0 F10 F3 PLAT SERPINE1
2 mucormycosis 30.3 CSF2 IFNG
3 antiphospholipid syndrome 29.8 F10 F3 PLAT
4 myocardial infarction 28.5 F10 F3 ITGA2B NOS3 PLAT SERPINE1
5 leech infestation 10.3 F10 F3
6 heparin-induced thrombocytopenia 10.3 F10 F3
7 acquired hemophilia 10.3 F10 F3
8 hemophilia a 10.3 F10 F3
9 vertebral artery occlusion 10.2 CSF2 F3
10 blue toe syndrome 10.2 F3 SERPINE1
11 factor vii deficiency 10.2 F10 F3
12 large granular lymphocyte leukemia 10.2 CSF2 IFNG
13 catastrophic antiphospholipid syndrome 10.2 F3 SERPINE1
14 marantic endocarditis 10.2 F3 PLAT
15 dysbaric osteonecrosis 10.2 F3 SERPINE1
16 hemophilia b 10.2 F10 F3
17 trichosporonosis 10.2 CSF2 IFNG
18 intracranial vasospasm 10.2 NOS3 PLAT
19 candida glabrata 10.2 CSF2 IFNG
20 human t-cell leukemia virus type 2 10.2 CSF2 IFNG
21 factor xiii deficiency 10.2 F3 SERPINE1
22 meconium aspiration syndrome 10.2 CSF2 IFNG
23 factor x deficiency 10.2 F10 F3
24 lemierre's syndrome 10.2 F3 SERPINE1
25 afibrinogenemia 10.2 F10 F3
26 cyclic neutropenia 10.2 CSF2 IFNG
27 cytomegalovirus retinitis 10.2 CSF2 IFNG
28 grange syndrome 10.2 F3 PLAT
29 factor v deficiency 10.2 F10 F3
30 buerger disease 10.2 NOS3 SERPINE1
31 cryptococcal meningitis 10.2 CSF2 IFNG
32 inherited blood coagulation disease 10.1 F3 ITGA2B
33 fibrinolytic defect 10.1 PLAT SERPINE1
34 blood coagulation disease 10.1 F3 ITGA2B
35 intracranial thrombosis 10.1 F3 ITGA2B
36 plasminogen activator inhibitor-1 deficiency 10.1 PLAT SERPINE1
37 angina pectoris 10.1 NOS3 PLAT
38 argentine hemorrhagic fever 10.1 PLAT SERPINE1
39 central serous chorioretinopathy 10.1 PLAT SERPINE1
40 intracranial hypertension 10.1 F3 SERPINE1
41 acute cor pulmonale 10.1 PLAT SERPINE1
42 thrombophlebitis 10.1 PLAT SERPINE1
43 paranasal sinus disease 10.1 IFNG SERPINE1
44 acute pulmonary heart disease 10.1 PLAT SERPINE1
45 von willebrand disease, type 2 10.1 F3 ITGA2B
46 head injury 10.1
47 thrombasthenia 10.1 F3 ITGA2B
48 aspirin allergy 10.1 ITGA2B SERPINE1
49 afibrinogenemia, congenital 10.0 F3 PLAT
50 pulmonary artery disease 10.0 F10 F3 PLAT

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to Carotid Artery Thrombosis

Symptoms & Phenotypes for Carotid Artery Thrombosis

GenomeRNAi Phenotypes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.8 F3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.8 F3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.8 ADAMTS18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.8 ADAMTS18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.8 ADAMTS18
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.8 ADAMTS18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.8 CSF2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.8 ADAMTS18 CSF2 F3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.8 F3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.8 ADAMTS18
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.8 ADAMTS18
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.8 CSF2
13 Increased Sindbis virus (SINV) infection GR00310-A-1 9.1 CSF2 NOS3 PLAT
14 Increased Sindbis virus (SINV) infection GR00310-A-2 9.1 CSF2 NOS3 PLAT

MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 CSF2 F10 F3 IFNG ITGA2B NOS3
2 homeostasis/metabolism MP:0005376 10.06 ADAMTS18 CSF2 F10 F3 IFNG ITGA2B
3 growth/size/body region MP:0005378 10 ADAMTS18 CSF2 F3 IFNG NOS3 PLAT
4 hematopoietic system MP:0005397 9.98 CSF2 F3 IFNG ITGA2B NOS3 PLAT
5 immune system MP:0005387 9.97 ADAMTS18 CSF2 F3 IFNG ITGA2B NOS3
6 digestive/alimentary MP:0005381 9.88 ADAMTS18 IFNG ITGA2B NOS3 PLAT
7 integument MP:0010771 9.72 CSF2 F3 IFNG PLAT SERPINE1
8 reproductive system MP:0005389 9.7 ADAMTS18 CSF2 F10 IFNG ITGA2B NOS3
9 neoplasm MP:0002006 9.65 ADAMTS18 CSF2 F3 IFNG SERPINE1
10 respiratory system MP:0005388 9.5 ADAMTS18 CSF2 F3 IFNG NOS3 PLAT
11 vision/eye MP:0005391 9.02 ADAMTS18 F3 IFNG NOS3 PLAT

Drugs & Therapeutics for Carotid Artery Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy Completed NCT02341196 Not Applicable
2 Selective Versus Routine Shunting in Carotid Endarterectomy Patients Completed NCT00967486 Not Applicable

Search NIH Clinical Center for Carotid Artery Thrombosis

Cochrane evidence based reviews: carotid artery thrombosis

Genetic Tests for Carotid Artery Thrombosis

Anatomical Context for Carotid Artery Thrombosis

MalaCards organs/tissues related to Carotid Artery Thrombosis:

42
Brain, Liver, Endothelial

Publications for Carotid Artery Thrombosis

Articles related to Carotid Artery Thrombosis:

(show top 50) (show all 122)
# Title Authors Year
1
Antiphospholipid syndrome causing reversible internal carotid artery thrombosis. ( 30070223 )
2018
2
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury. ( 30247470 )
2018
3
Photoacoustic Imaging: A Novel Tool for Detecting Carotid Artery Thrombosis in Mice. ( 28689199 )
2017
4
PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances antia89thrombotic effect in a rat carotid artery thrombosis model. ( 28791355 )
2017
5
Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat. ( 28487554 )
2017
6
Simultaneous Occurrence of Deep Vein Thrombosis and Carotid Artery Thrombosis in Antiphospholipid Antibody Syndrome. ( 28479827 )
2017
7
The effect of pravastatin on carotid artery thrombosis in rats under the stimulus of C-reactive protein. ( 27416543 )
2016
8
The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. ( 26660522 )
2016
9
A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma. ( 30755874 )
2016
10
Direct penetrating and indirect neck trauma as a cause of internal carotid artery thrombosis and secondary ischemic stroke. ( 24748050 )
2014
11
Detection of activated platelets in a mouse model of carotid artery thrombosis with 18 F-labeled single-chain antibodies. ( 24440583 )
2014
12
Carotid artery thrombosis treated with catheter intervention using proximal occlusion and flow reversal. ( 23645056 )
2013
13
Internal carotid artery thrombosis due to an unusual soft palate injury in a child. ( 24317280 )
2013
14
Spontaneous free floating carotid artery thrombosis. ( 23749854 )
2013
15
Symptomatic internal carotid artery thrombosis in acute carbon monoxide intoxication. ( 24388067 )
2013
16
Iridoid glycosides extracted from zhizi (fructus gardeniae) decrease collagen-induced platelet aggregation and reduce carotid artery thrombosis in an in vivo rat model. ( 24187877 )
2013
17
Preparation of thrombosis-targeted lipid microbubbles and determination of rabbit carotid artery thrombosis by microbubbles ultrasonogaphy. ( 23392725 )
2013
18
Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury. ( 22945770 )
2012
19
Carotid artery thrombosis in a child with membranous nephropathy associated with factor V Leiden mutation. ( 22830551 )
2012
20
Asymptomatic external carotid artery thrombosis in acute stroke. ( 22549811 )
2012
21
Internal carotid artery thrombosis and its evolution documented by computed tomography angiography. ( 24765384 )
2011
22
Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody. ( 21479193 )
2011
23
A highly constrained cyclic (S,S)-CDC- peptide is a potent inhibitor of carotid artery thrombosis in rabbits. ( 21158497 )
2011
24
Internal carotid artery thrombosis after blunt trauma--salvage therapy with the penumbra thrombectomy system. ( 20349674 )
2010
25
Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. ( 20694780 )
2010
26
Effect of a synthetic peptide corresponding to residues 313 to 320 of the alphaIIb subunit of the human platelet integrin alphaIIbbeta3 on carotid artery thrombosis in rabbits. ( 19244095 )
2009
27
Carotid artery thrombosis and delayed stroke associated with the use of a shoulder belt in a teenager. ( 19635289 )
2009
28
Images from headache: cluster-like headache associated with intra-cavernous carotid artery thrombosis. ( 18808501 )
2008
29
Effects of propyl gallate on carotid artery thrombosis and coagulation/fibrinolysis system in rats. ( 18568328 )
2008
30
Acute carotid artery thrombosis: description of 12 surgically treated cases. ( 15714361 )
2005
31
Rhinocerebral mucormycosis complicated by internal carotid artery thrombosis in a pediatric patient with type 1 diabetes mellitus: a case report and review of the literature. ( 16390393 )
2005
32
Prevention of carotid artery thrombosis after oral administration of the glycoprotein IIb/IIIa antagonist CRL42796. ( 12827029 )
2003
33
Differential effects of sodium nitroprusside and hydralazine in a rat model of topical FeCl3-induced carotid artery thrombosis. ( 14644081 )
2003
34
Images in clinical medicine. Carotid-artery thrombosis secondary to basal skull fracture. ( 12890856 )
2003
35
Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice. ( 14675104 )
2003
36
Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase. ( 12876627 )
2003
37
Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis. ( 14556079 )
2003
38
Endothelial nitric oxide synthase pathophysiology after nonocclusive common carotid artery thrombosis in rats. ( 11973434 )
2002
39
Visual disturbance due to carotid artery thrombosis in a patient with familial hypercholesterolemia; response to surgical thrombotectomy. ( 11393415 )
2001
40
Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis. ( 10991981 )
2000
41
S-nitrosoderivative of a recombinant fragment of von Willebrand factor (S-nitroso-AR545C) inhibits thrombus formation in guinea pig carotid artery thrombosis model. ( 11127876 )
2000
42
Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis. ( 10688985 )
2000
43
Delayed bilateral internal carotid artery thrombosis following accidental strangulation. ( 10823110 )
2000
44
A porcine model of carotid artery thrombosis for thrombolytic therapy and angioplasty: application of PTFE graft-induced stenosis. ( 10883961 )
2000
45
The role of oculopneumoplethysmography in detecting acute carotid artery thrombosis in patients with neurologic deficits after carotid endarterectomy. ( 10875996 )
2000
46
Internal carotid artery thrombosis and Horner's syndrome as complications of parapharyngeal abscess. ( 10388902 )
1999
47
An alternative model of carotid artery thrombosis in rats. ( 10605956 )
1999
48
Traumatic internal carotid artery thrombosis after impalement injury. ( 9419147 )
1997
49
Carotid artery thrombosis and stroke after blunt pharyngeal injury. ( 9095125 )
1997
50
Prevention of carotid artery thrombosis by oral platelet GPIIb/IIIa antagonist in dogs. ( 9099204 )
1997

Variations for Carotid Artery Thrombosis

Expression for Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for Carotid Artery Thrombosis

Pathways related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 CSF2 F10 F3 ITGA2B NOS3 PLAT
2
Show member pathways
12.03 IFNG PLAT SERPINE1
3 11.81 NOS3 PLAT SERPINE1
4
Show member pathways
11.76 F10 F3 PLAT SERPINE1
5
Show member pathways
11.75 CSF2 IFNG PLAT
6 11.67 CSF2 IFNG ITGA2B
7 11.61 IFNG PLAT SERPINE1
8 11.6 F10 F3 PLAT SERPINE1
9 11.54 IFNG NOS3 SERPINE1
10 11.5 F3 NOS3 SERPINE1
11 11.4 IFNG ITGA2B NOS3 PLAT
12 11.32 IFNG SERPINE1
13 11.3 ITGA2B SERPINE1
14 11.22 CSF2 ITGA2B
15 10.97 CSF2 IFNG
16 10.57 PLAT SERPINE1

GO Terms for Carotid Artery Thrombosis

Cellular components related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 CSF2 F10 F3 IFNG PLAT SERPINE1
2 extracellular region GO:0005576 9.5 ADAMTS18 CSF2 F10 F3 IFNG PLAT
3 collagen-containing extracellular matrix GO:0062023 9.43 F3 PLAT SERPINE1
4 intrinsic component of external side of plasma membrane GO:0031233 8.62 F10 F3

Biological processes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.54 F10 F3 PLAT
2 hemostasis GO:0007599 9.43 F10 F3
3 positive regulation of angiogenesis GO:0045766 9.43 F3 NOS3 SERPINE1
4 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.4 NOS3 SERPINE1
5 fibrinolysis GO:0042730 9.32 PLAT SERPINE1
6 response to fluid shear stress GO:0034405 9.16 CSF2 NOS3
7 positive regulation of interleukin-23 production GO:0032747 8.96 CSF2 IFNG
8 blood coagulation, extrinsic pathway GO:0007598 8.62 F10 F3

Molecular functions related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F10 F3 PLAT

Sources for Carotid Artery Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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