MCID: CRT004
MIFTS: 38

Carotid Artery Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases
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Aliases & Classifications for Carotid Artery Thrombosis

MalaCards integrated aliases for Carotid Artery Thrombosis:

Name: Carotid Artery Thrombosis 11 53 43 14 16 71

Classifications:



External Ids:

Disease Ontology 11 DOID:3410
MeSH 43 D002341
SNOMED-CT 68 195181000
UMLS 71 C0007274

Summaries for Carotid Artery Thrombosis

MalaCards based summary: Carotid Artery Thrombosis is related to exanthem and carotid stenosis. An important gene associated with Carotid Artery Thrombosis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include brain, endothelial and neutrophil, and related phenotypes are homeostasis/metabolism and nervous system

Related Diseases for Carotid Artery Thrombosis

Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 exanthem 30.2 IFNG F3 CSF2
2 carotid stenosis 30.2 VWF SELP NOS3 IFNG
3 severe covid-19 30.0 VWF IFNG F3 CSF2
4 mastoiditis 30.0 SERPINC1 F3
5 buerger disease 30.0 SERPINC1 NOS3
6 cerebrovascular disease 29.8 SELP PLG PLAT P2RY12
7 thrombocytosis 29.7 VWF SERPINC1 SELP F3 CSF2
8 carotid artery occlusion 29.7 SELP PLG PLAT GP6 F11
9 middle cerebral artery infarction 29.7 PLG PLAT F3
10 acute promyelocytic leukemia 29.7 SELP PLAT IFNG F3 CSF2
11 aspergillosis 29.6 PLG IFNG CSF2
12 hellp syndrome 29.4 VWF SERPINE1 SERPINC1 PLAT F3
13 antithrombin iii deficiency 29.4 SERPINC1 PLG F3 F10
14 factor viii deficiency 29.4 VWF SERPINC1 F3 F11 F10
15 thrombophilia due to thrombin defect 29.3 VWF SERPINE1 SERPINC1 SELP PLAT F3
16 transient cerebral ischemia 29.2 VWF SERPINC1 PLG PLAT P2RY12 F3
17 antiphospholipid syndrome 28.9 VWF SERPINE1 SERPINC1 SELP PLAT GP1BA
18 carotid artery disease 28.7 VWF SELP PLG PLAT P2RY12 ITGA2B
19 vascular disease 28.7 VWF SERPINE1 SERPINC1 SELP PLAT NOS3
20 pulmonary embolism 28.7 VWF SERPINE1 SERPINC1 PLAT GP6 GP1BA
21 thrombophlebitis 28.6 VWF SERPINE1 SERPINC1 SELP PLG PLAT
22 thrombophilia 28.5 VWF SERPINE1 SERPINC1 SELP PLAT NOS3
23 disseminated intravascular coagulation 28.2 VWF SERPINE1 SERPINC1 PLG PLAT F3
24 thrombosis 27.7 VWF SERPINE1 SERPINC1 SELP PLG PLAT
25 stroke, ischemic 27.7 VWF SERPINE1 SERPINC1 SELP PLG PLAT
26 thrombocytopenia 26.8 VWF SERPINE1 SERPINC1 SELP PLAT P2RY12
27 epidural abscess 10.3 IFNG F3
28 candida glabrata 10.3 IFNG CSF2
29 intracranial arteriosclerosis 10.3 SERPINE1 SELP
30 mucormycosis 10.2
31 heparin-induced thrombocytopenia 10.2 ITGA2B F3
32 femoral neuropathy 10.2 PLAT F3
33 peyronie's disease 10.2 SERPINE1 NOS3
34 splenic disease 10.2 IFNG F3 CSF2
35 aspirin allergy 10.2 P2RY12 ITGA2B
36 brachydactyly, type d 10.2 VWF F3 F10
37 eisenmenger syndrome 10.2 VWF PLAT
38 trimethoprim allergy 10.2 IFNG GP1BA
39 hemophilia a 10.2 VWF F3 F10
40 fetal and neonatal alloimmune thrombocytopenia 10.2 ITGA2B GP1BA
41 hemophagocytic lymphohistiocytosis 10.2 IFNG F3 CSF2
42 autosomal dominant macrothrombocytopenia 10.1 ITGA2B GP1BA
43 central serous chorioretinopathy 10.1 SERPINE1 PLAT
44 achenbach syndrome 10.1 SERPINC1 F3
45 scott syndrome 10.1 ITGA2B GP6 F10
46 high molecular weight kininogen deficiency 10.1 F3 F11
47 childhood acute megakaryoblastic leukemia 10.1 ITGA2B GP1BA
48 autoimmune disease of blood 10.1 VWF ITGA2B F3
49 giant hemangioma 10.1 SERPINC1 F3
50 preeclampsia/eclampsia 1 10.1 SERPINC1 NOS3

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to Carotid Artery Thrombosis

Symptoms & Phenotypes for Carotid Artery Thrombosis

GenomeRNAi Phenotypes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.13 CSF2 F10 F11 F2R F3 GP1BA
2 no effect GR00402-S-2 10.13 CSF2 F10 F2R F3 GP1BA GP6

MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 CSF2 F10 F11 F2R F3 GP1BA
2 nervous system MP:0003631 10.35 CSF2 F11 F2R F3 IFNG ITGA2B
3 growth/size/body region MP:0005378 10.32 CSF2 F10 F11 F2R F3 IFNG
4 cardiovascular system MP:0005385 10.3 CSF2 F10 F11 F2R F3 IFNG
5 cellular MP:0005384 10.29 CSF2 F11 F2R F3 GP1BA IFNG
6 immune system MP:0005387 10.28 CSF2 F11 F2R F3 GP6 IFNG
7 renal/urinary system MP:0005367 10.21 CSF2 F10 F2R IFNG NOS3 PLG
8 liver/biliary system MP:0005370 10.14 F11 F2R IFNG NOS3 PLG SELP
9 muscle MP:0005369 10.09 F11 F3 IFNG NOS3 PLAT SERPINC1
10 reproductive system MP:0005389 10.07 CSF2 F10 F2R GP6 IFNG ITGA2B
11 respiratory system MP:0005388 10.06 CSF2 F11 F3 IFNG NOS3 PLAT
12 hematopoietic system MP:0005397 10.06 CSF2 F11 F2R F3 GP1BA GP6
13 neoplasm MP:0002006 10.05 CSF2 F2R F3 IFNG PLG SERPINE1
14 digestive/alimentary MP:0005381 10.04 F2R IFNG ITGA2B NOS3 PLAT PLG
15 skeleton MP:0005390 9.97 CSF2 F2R GP6 IFNG ITGA2B NOS3
16 vision/eye MP:0005391 9.91 F2R F3 GP6 IFNG NOS3 PLAT
17 mortality/aging MP:0010768 9.83 CSF2 F10 F11 F2R F3 GP6
18 integument MP:0010771 9.28 CSF2 F3 GP6 IFNG ITGA2B PLAT

Drugs & Therapeutics for Carotid Artery Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy. Long-term Results Completed NCT02341196

Search NIH Clinical Center for Carotid Artery Thrombosis

Cochrane evidence based reviews: carotid artery thrombosis

Genetic Tests for Carotid Artery Thrombosis

Anatomical Context for Carotid Artery Thrombosis

Organs/tissues related to Carotid Artery Thrombosis:

MalaCards : Brain, Endothelial, Neutrophil, Myeloid, Cortex, Eye, Kidney

Publications for Carotid Artery Thrombosis

Articles related to Carotid Artery Thrombosis:

(show top 50) (show all 456)
# Title Authors PMID Year
1
Antithrombotic activity of a monoclonal antibody inducing the substrate form of plasminogen activator inhibitor type 1 in rat models of venous and arterial thrombosis. 53 62
9776340 1998
2
Inhibition of endothelial cell expression of plasminogen activator inhibitor type-1 by gemfibrozil. 53 62
7509512 1993
3
An unusual case of carotidynia preceding recurrent ischemic stroke with carotid thrombosis in a patient with systemic lupus erythematosus. 62
36289010 2022
4
Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength. 62
35659185 2022
5
Bifunctional fusion protein targeting both FXIIa and FXIa displays potent anticoagulation effects. 62
36208658 2022
6
Exclusively Posterior Circulation Stroke Caused by Internal Carotid Artery Thrombosis. 62
36395504 2022
7
Neutrophil Recruitment in Arterial Thrombus and Characteristics of Stroke Patients with Neutrophil-Rich Thrombus. 62
36303310 2022
8
Study on the antithrombotic effect and physiological mechanism of okanin. 62
35785699 2022
9
Petrous Carotid Artery Thrombosis in an Immunocompromised Patient Presenting With Mastoiditis, A Case Report. 62
36154465 2022
10
Common carotid artery thrombosis and malignant middle cerebral artery infarction following ovarian hyperstimulation syndrome: A case report. 62
36159413 2022
11
Effective components and mechanism analysis of anti-platelet aggregation effect of Justicia procumbens L. 62
35589019 2022
12
Panax Notoginseng Saponins Combined with Dual Antiplatelet Drugs Potentiates Anti-Thrombotic Effect with Alleviated Gastric Injury in A Carotid Artery Thrombosis Rat Model. 62
35716522 2022
13
CT-001 is a rapid clearing factor VIIa with enhanced clearance and hemostatic activity for the treatment of acute bleeding in non-hemophilia settings. 62
35640516 2022
14
Engineered platelets-based drug delivery platform for targeted thrombolysis. 62
35847517 2022
15
Establishment of a Modified and Standardized Ferric Chloride-Induced Rat Carotid Artery Thrombosis Model. 62
35309441 2022
16
XJ-8, a natural compound isolated from Sanguis draxonis, inhibits platelet function and thrombosis by targeting MAP3K3. 62
34780114 2022
17
Endothelial Dysfunction in SARS-CoV-2 Infection. 62
35327455 2022
18
Thrombolytic and anticoagulant effects of a recombinant staphylokinase-hirudin fusion protein. 62
34688099 2021
19
Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. 62
34846914 2021
20
Anterior Cavernous and Internal Carotid Artery Thrombosis - A Rare Complication of Rhino-orbito-cerebral Mucormycosis. 62
34979719 2021
21
WPK5, a Novel Kunitz-Type Peptide from the Leech Whitmania pigra Inhibiting Factor XIa, and Its Loop-Replaced Mutant to Improve Potency. 62
34944561 2021
22
A Nano-Based P1Cminimum Probe to Monitor Thrombosis in Grafts and Improve Cardiac Function After Coronary Artery Bypass Grafting Surgery. 62
34706795 2021
23
Symptomatic Carotid Artery Thrombosis in a Patient Recently Recovered From a COVID-19 Infection. 62
34659924 2021
24
Left Carotid Artery Thrombosis Due to Thromboangiitis Obliterans. 62
33346979 2021
25
Mitochondrial reactive oxygen species scavenging attenuates thrombus formation in a murine model of sickle cell disease. 62
33724688 2021
26
Preparation and Properties of Thrombus-Targeted Urokinase/Multi-Walled Carbon Nanotubes (MWCNTs)-Chitosan (CS)-RGD Drug Delivery System. 62
34688316 2021
27
Diagnostic Utility of Polymerase Chain Reaction for Paraffin-embedded Sinus Specimens for Rhinocerebral Mucormycosis Complicated by Internal Carotid Artery Thrombosis and Cerebral Infarction. 62
33678746 2021
28
COVID-19-associated ischaemic stroke due to underlying carotid artery thrombosis in a healthy young woman. 62
34344659 2021
29
RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A. 62
33996250 2021
30
Improved efficacy/safety profile of factor XIa inhibitor BMS-724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys. 62
34095733 2021
31
Wasp sting - Causing a fatal menace. 62
34189358 2021
32
Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation. 62
33919019 2021
33
Delayed stroke after hospitalization for coronavirus disease 2019 pneumonia from common and internal carotid artery thrombosis. 62
33200108 2021
34
NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis. 62
33267663 2021
35
QiShenYiQi Inhibits Tissue Plasminogen Activator-Induced Brain Edema and Hemorrhage after Ischemic Stroke in Mice. 62
35095486 2021
36
Skull base osteomyelitis with secondary cavernous sinus thrombosis: a rare presentation of an animate foreign body in the ear. 62
33431445 2021
37
[Carotid endarterectomy in patients with internal carotid artery thrombosis in the acutest period of ischemic stroke with COVID-19]. 62
34874651 2021
38
Rare presentations of COVID-19: PRES-like leukoencephalopathy and carotid thrombosis. 62
32707411 2021
39
A rare infective cause of stroke in an immunocompetent child. 62
32855000 2021
40
Ref-1 protects against FeCl3-induced thrombosis and tissue factor expression via the GSK3β-NF-κB pathway. 62
33361538 2021
41
Case Report: Internal Carotid Artery Thrombosis: A Rare Complication After Fibrin Glue Injection for Cavernous Sinus Hemostasis. 62
34796197 2021
42
Acute ischemic stroke complicating common carotid artery thrombosis during a severe COVID-19 infection. 62
32389423 2020
43
Durable Response to Pazopanib in Recurrent Metastatic Carotid Body Paraganglioma. 62
33173489 2020
44
Selective Hand Motor Cortex Lesions Masquerading as "Pseudoperipheral Nerve Palsy". 62
33623273 2020
45
Internal carotid artery thrombosis in COVID 19. 62
33402757 2020
46
Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model. 62
32205561 2020
47
Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation. 62
32195632 2020
48
Ischaemic Stroke Caused by a Gunshot Wound to the Chest. 62
32881990 2020
49
Linagliptin Regulates the Mitochondrial Respiratory Reserve to Alter Platelet Activation and Arterial Thrombosis. 62
33328991 2020
50
Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets. 62
32850895 2020

Variations for Carotid Artery Thrombosis

Expression for Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for Carotid Artery Thrombosis

Pathways related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1 13.43 CSF2 F2R F3 ITGA2B NOS3 P2RY12
2
Show member pathways
12.56 VWF SERPINE1 SERPINC1 SELP PLG PLAT
3
Show member pathways
12.43 SELP PLG ITGA2B IFNG F10
4
Show member pathways
12.16 VWF SERPINE1 SERPINC1 PLG PLAT GP6
5 11.82 SERPINE1 PLG F3
6 11.77 ITGA2B IFNG GP1BA CSF2
7 11.73 SERPINE1 PLAT IFNG
8
Show member pathways
11.68 VWF ITGA2B GP1BA
9 11.64 VWF NOS3 F3
10 11.46 SERPINE1 PLG PLAT
11 11.26 VWF P2RY12 ITGA2B GP6 F2R
12 11.1 PLAT GP1BA F10
13 11.07 SELP PLG PLAT
14
Show member pathways
10.98 VWF GP6 GP1BA
15 10.72 IFNG CSF2
16 10.55 SERPINE1 PLG PLAT

GO Terms for Carotid Artery Thrombosis

Cellular components related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.34 CSF2 F10 F11 F2R F3 IFNG
2 collagen-containing extracellular matrix GO:0062023 10 VWF SERPINE1 SERPINC1 PLG PLAT F3
3 platelet alpha granule lumen GO:0031093 9.88 VWF SERPINE1 PLG
4 cell surface GO:0009986 9.86 PLG PLAT P2RY12 ITGA2B GP6 GP1BA
5 extracellular space GO:0005615 9.7 CSF2 F10 F11 F3 GP1BA IFNG
6 serine protease inhibitor complex GO:0097180 9.67 SERPINE1 PLAT
7 obsolete intrinsic component of external side of plasma membrane GO:0031233 9.16 F10 F3

Biological processes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 10.02 F2R GP1BA GP6 P2RY12 VWF
2 positive regulation of interleukin-8 production GO:0032757 9.99 SERPINE1 F3 F2R
3 blood coagulation GO:0007596 9.93 F10 F11 F2R F3 GP1BA GP6
4 fibrinolysis GO:0042730 9.86 SERPINE1 PLG PLAT GP1BA
5 plasminogen activation GO:0031639 9.85 PLAT F11
6 negative regulation of fibrinolysis GO:0051918 9.85 SERPINE1 PLG PLAT
7 positive regulation of platelet activation GO:0010572 9.84 SELP GP1BA
8 thrombin-activated receptor signaling pathway GO:0070493 9.83 GP1BA F2R
9 negative regulation of plasminogen activation GO:0010757 9.8 PLAT SERPINE1
10 response to fluid shear stress GO:0034405 9.78 CSF2 NOS3
11 positive regulation of interleukin-23 production GO:0032747 9.76 IFNG CSF2
12 positive regulation of fibrinolysis GO:0051919 9.73 PLG F11
13 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.71 PLG PLAT
14 regulation of blood coagulation GO:0030193 9.63 SERPINC1 GP1BA F2R F11
15 hemostasis GO:0007599 9.4 F10 F11 F2R F3 GP1BA GP6

Molecular functions related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.76 VWF SERPINE1 SERPINC1 F3
2 thrombin-activated receptor activity GO:0015057 9.56 GP1BA F2R
3 serine-type peptidase activity GO:0008236 9.35 PLG PLAT F11 F10
4 serine-type endopeptidase activity GO:0004252 9.32 PLG PLAT F3 F11 F10

Sources for Carotid Artery Thrombosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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