MCID: CRT004
MIFTS: 38

Carotid Artery Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Artery Thrombosis

MalaCards integrated aliases for Carotid Artery Thrombosis:

Name: Carotid Artery Thrombosis 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3410
MeSH 43 D002341
SNOMED-CT 67 86003009
UMLS 71 C0007274

Summaries for Carotid Artery Thrombosis

MalaCards based summary : Carotid Artery Thrombosis is related to carotid artery occlusion and cerebrovascular disease. An important gene associated with Carotid Artery Thrombosis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. Affiliated tissues include heart, brain and myeloid, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Carotid Artery Thrombosis

Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 carotid artery occlusion 30.1 PLG PLAT NOS3 CIART
2 cerebrovascular disease 29.7 VWF SERPINE1 SELP PLAT ITGA2B
3 carotid artery disease 29.7 SELP PLG PLAT F3
4 antithrombin iii deficiency 29.5 SERPINC1 PLG F10
5 thrombocytosis 29.3 VWF SERPINC1 SELP F3 CSF2
6 hellp syndrome 29.0 VWF SERPINE1 SERPINC1 PLAT F3
7 acute promyelocytic leukemia 28.7 SERPINE1 SERPINC1 SELP PLAT F3 CSF2
8 antiphospholipid syndrome 28.6 VWF SERPINE1 SERPINC1 SELP PLAT F3
9 thrombophilia 27.8 VWF SERPINE1 SERPINC1 SELP PLG PLAT
10 thrombosis 27.6 VWF SERPINE1 SERPINC1 SELP PLG PLAT
11 vascular disease 27.3 VWF SERPINE1 SERPINC1 SELP PLG PLAT
12 stroke, ischemic 26.7 VWF SERPINE1 SERPINC1 SELP PLG PLAT
13 myocardial infarction 25.7 VWF SERPINE1 SERPINC1 SELP PLG PLAT
14 acquired hemophilia 10.5 F3 F10
15 catastrophic antiphospholipid syndrome 10.4 SERPINE1 F3
16 platelet membrane fluidity 10.4 SELP NOS3
17 human t-cell leukemia virus type 2 10.4 IFNG CSF2
18 candida glabrata 10.4 IFNG CSF2
19 papillary adenofibroma 10.4 VWF F3
20 central serous chorioretinopathy 10.3 SERPINE1 PLAT
21 splenic disease 10.3 IFNG F3 CSF2
22 mycoplasma pneumoniae pneumonia 10.3 IFNG F3 CSF2
23 plasminogen activator inhibitor-1 deficiency 10.3 SERPINE1 PLAT
24 active peptic ulcer disease 10.3 VWF F3
25 hemarthrosis 10.3 VWF F3 F10
26 factor x deficiency 10.2 VWF F3 F10
27 factor v deficiency 10.2 VWF F3 F10
28 thrombasthenia 10.2 SELP ITGA2B F3
29 factor viii deficiency 10.2 VWF F3 F10
30 acquired von willebrand syndrome 10.2 VWF F3
31 polycystic echinococcosis 10.2 F3 CIART
32 hemopericardium 10.2 PLG F3
33 monocytic leukemia 10.2 IFNG F3 CSF2
34 quebec platelet disorder 10.2 SERPINE1 SELP F10
35 acute anterolateral myocardial infarction 10.2 PLG ITGA2B
36 fournier gangrene 10.2 SERPINC1 F3
37 angina pectoris 10.2 PLAT NOS3 F3
38 vulvar angiokeratoma 10.2 SERPINC1 F3
39 blue toe syndrome 10.2 SERPINC1 F3
40 splenic sequestration 10.2 VWF ITGA2B F3
41 hepatic infarction 10.2 SERPINC1 F3
42 head injury 10.2
43 puerperal pulmonary embolism 10.2 SERPINC1 F10
44 giant hemangioma 10.2 SERPINC1 F3
45 autoimmune disease of blood 10.2 VWF ITGA2B F3
46 cardiac tuberculosis 10.2 SERPINE1 SERPINC1
47 orofacial granulomatosis 10.1 IFNG F2R
48 eisenmenger syndrome 10.1 VWF PLAT
49 prothrombin deficiency, congenital 10.1 SERPINC1 F10
50 basal ganglia cerebrovascular disease 10.1 PLG PLAT

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to Carotid Artery Thrombosis

Symptoms & Phenotypes for Carotid Artery Thrombosis

MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.4 CIART CSF2 F10 F2R F3 GP6
2 cardiovascular system MP:0005385 10.36 CSF2 F10 F2R F3 IFNG ITGA2B
3 hematopoietic system MP:0005397 10.32 CSF2 F2R F3 GP6 IFNG ITGA2B
4 immune system MP:0005387 10.29 CSF2 F2R F3 GP6 IFNG ITGA2B
5 mortality/aging MP:0010768 10.28 CIART CSF2 F10 F2R F3 GP6
6 cellular MP:0005384 10.24 CSF2 F2R F3 IFNG ITGA2B NOS3
7 digestive/alimentary MP:0005381 10.07 F2R IFNG ITGA2B NOS3 PLAT PLG
8 integument MP:0010771 10.06 CSF2 F3 GP6 IFNG PLAT PLG
9 nervous system MP:0003631 10.02 CSF2 F2R F3 IFNG NOS3 PLAT
10 liver/biliary system MP:0005370 9.98 F2R IFNG NOS3 PLG SELP SERPINC1
11 renal/urinary system MP:0005367 9.86 CSF2 F2R IFNG NOS3 PLG SELP
12 neoplasm MP:0002006 9.85 CSF2 F2R F3 IFNG PLG SERPINE1
13 reproductive system MP:0005389 9.85 CSF2 F10 F2R GP6 IFNG ITGA2B
14 respiratory system MP:0005388 9.56 CSF2 F3 IFNG NOS3 PLAT PLG
15 vision/eye MP:0005391 9.28 F2R F3 GP6 IFNG NOS3 PLAT

Drugs & Therapeutics for Carotid Artery Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy. Long-term Results Completed NCT02341196

Search NIH Clinical Center for Carotid Artery Thrombosis

Cochrane evidence based reviews: carotid artery thrombosis

Genetic Tests for Carotid Artery Thrombosis

Anatomical Context for Carotid Artery Thrombosis

MalaCards organs/tissues related to Carotid Artery Thrombosis:

40
Heart, Brain, Myeloid, Endothelial, Kidney, Neutrophil, Eye

Publications for Carotid Artery Thrombosis

Articles related to Carotid Artery Thrombosis:

(show top 50) (show all 407)
# Title Authors PMID Year
1
Antithrombotic activity of a monoclonal antibody inducing the substrate form of plasminogen activator inhibitor type 1 in rat models of venous and arterial thrombosis. 54 61
9776340 1998
2
Inhibition of endothelial cell expression of plasminogen activator inhibitor type-1 by gemfibrozil. 54 61
7509512 1993
3
Rifled carotid: Internal carotid artery thrombosis from prolonged carrying of a military rifle. 61
31133623 2019
4
Intracranial invasive mycosis mimicking hepatic encephalopathy in a patient with cirrhosis. 61
31776153 2019
5
A bacterial metabolite, trimethylamine N-oxide, disrupts the hemostasis balance in human primary endothelial cells but no coagulopathy in mice. 61
31490208 2019
6
Intracardiac Thrombosis and Multiple Arterial Thromboembolism with Acute Limb Ischemia: A Rare Complication of Carbon Monoxide Intoxication. 61
31384115 2019
7
Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice. 61
30995985 2019
8
The mode of anesthesia influences outcome in mouse models of arterial thrombosis. 61
31011704 2019
9
Anticoagulant and Antithrombotic Properties in Vitro and in Vivo of a Novel Sulfated Polysaccharide from Marine Green Alga Monostroma nitidum. 61
31027312 2019
10
Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. 61
29608550 2019
11
Antithrombotic effects and related mechanisms of Salvia deserta Schang root EtOAc extracts. 61
30532017 2018
12
The Involvement of Toll-like Receptor-2 in Arterial Thrombus Formation. 61
30261531 2018
13
Humanized GPIbα-von Willebrand factor interaction in the mouse. 61
30287479 2018
14
Rhinocerebral Mucormycosis With Temporal Artery Thrombosis in an Adolescent Following HLA-haploidentical Stem Cell Transplantation. 61
29200154 2018
15
A meta-analysis of randomized trials comparing bovine pericardium and other patch materials for carotid endarterectomy. 61
30244928 2018
16
Arterial Thrombosis Is Accompanied by Elevated Mitogen-Activated Protein Kinase (MAPK) and Cyclooxygenase-2 (COX-2) Expression via Toll-Like Receptor 4 (TLR-4) Activation by S100A8/A9. 61
30367682 2018
17
Angioedema and Hemorrhage After 4.5-Hour tPA (Tissue-Type Plasminogen Activator) Thrombolysis Ameliorated by T541 via Restoring Brain Microvascular Integrity. 61
30354988 2018
18
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury. 61
30247470 2018
19
Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging. 61
29874911 2018
20
Antiphospholipid syndrome causing reversible internal carotid artery thrombosis. 61
30070223 2018
21
Role of isopeptidolysis in the process of thrombolysis. 61
29549778 2018
22
[Abnormal structure and dysfunction of platelets in CD226 knockout mice]. 61
29973320 2018
23
Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice. 61
29421655 2018
24
Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis. 61
29097799 2017
25
PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances anti‑thrombotic effect in a rat carotid artery thrombosis model. 61
28791355 2017
26
Preventive and therapeutic effect of brozopine on stroke in Dahl Salt-sensitive hypertensive rats. 61
28760439 2017
27
Non-Vitamin K Oral Anticoagulants (NOACs) and Their Reversal. 61
28735353 2017
28
Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi. 61
28487393 2017
29
Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid β-protein precursor abolishes its anti-thrombotic properties in vivo. 61
28499154 2017
30
Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum. 61
28363953 2017
31
Platelet microparticle-inspired clot-responsive nanomedicine for targeted fibrinolysis. 61
28314136 2017
32
BDNFVal66met polymorphism: a potential bridge between depression and thrombosis. 61
26705390 2017
33
Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat. 61
28487554 2017
34
Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease-associated thrombosis in mice. 61
28264799 2017
35
Simultaneous Occurrence of Deep Vein Thrombosis and Carotid Artery Thrombosis in Antiphospholipid Antibody Syndrome. 61
28479827 2017
36
Propagation of thrombosis by neutrophils and extracellular nucleosome networks. 61
27927771 2017
37
Photoacoustic Imaging: A Novel Tool for Detecting Carotid Artery Thrombosis in Mice. 61
28689199 2017
38
The Myosin II Inhibitor, Blebbistatin, Ameliorates FeCl3-induced Arterial Thrombosis via the GSK3β-NF-κB Pathway. 61
28539835 2017
39
Studies on New Activities of Enantiomers of 2-(2-Hydroxypropanamido) Benzoic Acid: Antiplatelet Aggregation and Antithrombosis. 61
28107496 2017
40
Antithrombotic Potential of Tormentil Extract in Animal Models. 61
28860991 2017
41
Cavernous sinus thrombosis secondary to aspergillus granuloma: A case report and review of the literature. 61
26860234 2016
42
Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation. 61
27444201 2016
43
The effect of pravastatin on carotid artery thrombosis in rats under the stimulus of C-reactive protein. 61
27416543 2016
44
Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice. 61
26790499 2016
45
The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. 61
26660522 2016
46
A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation. 61
26950760 2016
47
Preparation and evaluation a new generation of low molecular weight heparin. 61
27044828 2016
48
Angioinvasive rhinocerebral mucormycosis with complete unilateral thrombosis of internal carotid artery-case report and review of literature. 61
30363635 2016
49
Wdr1-Dependent Actin Reorganization in Platelet Activation. 61
27627652 2016
50
A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma. 61
30755874 2016

Variations for Carotid Artery Thrombosis

Expression for Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for Carotid Artery Thrombosis

Pathways related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 VWF SERPINE1 SERPINC1 SELP PLG PLAT
2
Show member pathways
12.13 SERPINE1 PLG PLAT IFNG
3 11.92 VWF SERPINE1 SERPINC1 PLG PLAT F3
4 11.9 SERPINE1 PLAT NOS3
5 11.88 PLAT NOS3 ITGA2B IFNG
6 11.84 SERPINE1 PLG F3
7 11.81 ITGA2B IFNG CSF2
8
Show member pathways
11.81 PLG PLAT IFNG CSF2
9 11.77 SERPINE1 NOS3 IFNG
10 11.75 SERPINE1 PLAT IFNG
11 11.75 VWF NOS3 ITGA2B GP6 F2R
12 11.71 SERPINE1 NOS3 F3
13 11.64 VWF NOS3 F3
14
Show member pathways
11.48 VWF SERPINE1 SERPINC1 PLG PLAT GP6
15 11.44 SERPINE1 PLG PLAT
16 11.33 VWF ITGA2B GP6 F2R
17 11.31 SELP PLG PLAT
18 10.66 SERPINE1 PLG PLAT
19 10.64 VWF GP6

GO Terms for Carotid Artery Thrombosis

Cellular components related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 SERPINE1 SERPINC1 SELP PLG PLAT IFNG
2 cell surface GO:0009986 9.73 PLG PLAT ITGA2B GP6 F3 F2R
3 extracellular region GO:0005576 9.65 VWF SERPINE1 SERPINC1 PLG PLAT IFNG
4 platelet alpha granule lumen GO:0031093 9.54 VWF SERPINE1 PLG
5 platelet alpha granule membrane GO:0031092 9.4 SELP ITGA2B
6 intrinsic component of external side of plasma membrane GO:0031233 9.32 F3 F10
7 collagen-containing extracellular matrix GO:0062023 9.1 VWF SERPINE1 SERPINC1 PLG PLAT F3

Biological processes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.7 VWF GP6 F2R
2 blood coagulation GO:0007596 9.56 VWF SERPINC1 PLG PLAT GP6 F3
3 platelet degranulation GO:0002576 9.55 VWF SERPINE1 SELP PLG ITGA2B
4 positive regulation of blood coagulation GO:0030194 9.51 SERPINE1 F2R
5 positive regulation of leukocyte migration GO:0002687 9.49 SELP ITGA2B
6 regulation of blood coagulation GO:0030193 9.48 SERPINC1 F2R
7 negative regulation of fibrinolysis GO:0051918 9.46 SERPINE1 PLG
8 response to fluid shear stress GO:0034405 9.43 NOS3 CSF2
9 fibrinolysis GO:0042730 9.43 SERPINE1 PLG PLAT
10 positive regulation of interleukin-23 production GO:0032747 9.4 IFNG CSF2
11 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.37 PLG PLAT
12 blood coagulation, extrinsic pathway GO:0007598 9.32 F3 F10
13 hemostasis GO:0007599 9.17 VWF SERPINC1 PLG GP6 F3 F2R

Molecular functions related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 WDTC1 VWF SERPINE1 SERPINC1 SELP PLG
2 signaling receptor binding GO:0005102 9.56 SERPINE1 PLG PLAT F2R
3 serine-type endopeptidase activity GO:0004252 9.46 PLG PLAT F3 F10
4 protease binding GO:0002020 8.92 VWF SERPINE1 SERPINC1 F3

Sources for Carotid Artery Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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