MCID: CRT004
MIFTS: 38

Carotid Artery Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Artery Thrombosis

MalaCards integrated aliases for Carotid Artery Thrombosis:

Name: Carotid Artery Thrombosis 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3410
MeSH 43 D002341
SNOMED-CT 67 86003009
UMLS 71 C0007274

Summaries for Carotid Artery Thrombosis

MalaCards based summary : Carotid Artery Thrombosis is related to carotid artery occlusion and exanthem. An important gene associated with Carotid Artery Thrombosis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and ECM-receptor interaction. Affiliated tissues include endothelial, brain and myeloid, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Carotid Artery Thrombosis

Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 carotid artery occlusion 30.6 PLAT NOS3 CIART
2 exanthem 30.2 IFNG F3 CSF2
3 carotid artery disease 29.8 VWF SELP PLAT F3
4 antithrombin iii deficiency 29.7 SERPINC1 F3 F10
5 thrombocytosis 29.1 VWF SERPINC1 SELP F3 CSF2
6 cerebrovascular disease 29.0 VWF SERPINE1 SELP PLAT ITGA2B GP1BA
7 hellp syndrome 28.7 VWF SERPINE1 SERPINC1 PLAT F3
8 antiphospholipid syndrome 28.3 VWF SERPINE1 SERPINC1 SELP PLAT F3
9 thrombophilia 28.1 VWF SERPINE1 SERPINC1 SELP PLAT F3
10 acute promyelocytic leukemia 28.0 VWF SERPINE1 SERPINC1 SELP PLAT F3
11 thrombosis 27.4 VWF SERPINE1 SERPINC1 SELP PLAT NOS3
12 vascular disease 27.0 VWF SERPINE1 SERPINC1 SELP PLAT NOS3
13 stroke, ischemic 26.6 VWF SERPINE1 SERPINC1 SELP PLAT NOS3
14 myocardial infarction 25.5 VWF SERPINE1 SERPINC1 SELP PLAT NOS3
15 acquired hemophilia 10.5 F3 F10
16 platelet membrane fluidity 10.4 SELP NOS3
17 catastrophic antiphospholipid syndrome 10.4 SERPINE1 F3
18 candida glabrata 10.4 IFNG CSF2
19 human t-cell leukemia virus type 2 10.4 IFNG CSF2
20 papillary adenofibroma 10.4 VWF F3
21 polycystic echinococcosis 10.3 F3 CIART
22 mycoplasma pneumoniae pneumonia 10.3 IFNG F3 CSF2
23 acute cor pulmonale 10.3 PLAT F3
24 acute pulmonary heart disease 10.3 PLAT F3
25 central serous chorioretinopathy 10.3 SERPINE1 PLAT
26 plasminogen activator inhibitor-1 deficiency 10.3 SERPINE1 PLAT
27 splenic sequestration 10.2 VWF F3
28 quebec platelet disorder 10.2 SERPINE1 SELP F10
29 generalized atherosclerosis 10.2 VWF SERPINE1
30 cerebral falx meningioma 10.2 PLAT F3
31 hemarthrosis 10.2 VWF F3 F10
32 factor v deficiency 10.2 VWF F3 F10
33 active peptic ulcer disease 10.2 VWF F3
34 monocytic leukemia 10.2 IFNG F3 CSF2
35 basilar artery occlusion 10.2 PLAT ITGA2B
36 factor viii deficiency 10.2 VWF F3 F10
37 trimethoprim allergy 10.2 IFNG GP1BA
38 medulloadrenal hyperfunction 10.2 VWF SERPINE1 F3
39 head injury 10.2
40 fetal and neonatal alloimmune thrombocytopenia 10.2 ITGA2B GP1BA
41 posterior cerebral artery infarction 10.2 PLAT F3
42 orofacial granulomatosis 10.2 IFNG F2R
43 angina pectoris 10.2 PLAT NOS3 F3
44 sleep apnea 10.2 SERPINE1 SELP NOS3
45 portal hypertension 10.2 VWF NOS3 F3
46 autosomal dominant macrothrombocytopenia 10.1 ITGA2B GP1BA
47 eisenmenger syndrome 10.1 VWF PLAT
48 acquired thrombocytopenia 10.1 ITGA2B GP1BA
49 aspirin allergy 10.1 WDTC1 ITGA2B
50 peritonitis 10.1 SERPINE1 SELP IFNG

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to Carotid Artery Thrombosis

Symptoms & Phenotypes for Carotid Artery Thrombosis

MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 CIART CSF2 F10 F2R F3 GP1BA
2 cardiovascular system MP:0005385 10.29 CSF2 F10 F2R F3 IFNG ITGA2B
3 hematopoietic system MP:0005397 10.29 CSF2 F2R F3 GP1BA GP6 IFNG
4 mortality/aging MP:0010768 10.28 CIART CSF2 F10 F2R F3 GP6
5 immune system MP:0005387 10.21 CSF2 F2R F3 GP6 IFNG ITGA2B
6 cellular MP:0005384 10.19 CSF2 F2R F3 GP1BA IFNG ITGA2B
7 nervous system MP:0003631 10.07 CSF2 F2R F3 IFNG ITGA2B NOS3
8 reproductive system MP:0005389 9.91 CSF2 F10 F2R GP6 IFNG ITGA2B
9 renal/urinary system MP:0005367 9.87 CSF2 F2R IFNG NOS3 SELP SERPINC1
10 respiratory system MP:0005388 9.7 CSF2 F3 IFNG NOS3 PLAT SELP
11 skeleton MP:0005390 9.56 CSF2 F2R IFNG ITGA2B NOS3 PLAT
12 vision/eye MP:0005391 9.23 F2R F3 GP6 IFNG NOS3 PLAT

Drugs & Therapeutics for Carotid Artery Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy. Long-term Results Completed NCT02341196

Search NIH Clinical Center for Carotid Artery Thrombosis

Cochrane evidence based reviews: carotid artery thrombosis

Genetic Tests for Carotid Artery Thrombosis

Anatomical Context for Carotid Artery Thrombosis

MalaCards organs/tissues related to Carotid Artery Thrombosis:

40
Endothelial, Brain, Myeloid, Neutrophil, Eye, Kidney, Liver

Publications for Carotid Artery Thrombosis

Articles related to Carotid Artery Thrombosis:

(show top 50) (show all 410)
# Title Authors PMID Year
1
Antithrombotic activity of a monoclonal antibody inducing the substrate form of plasminogen activator inhibitor type 1 in rat models of venous and arterial thrombosis. 61 54
9776340 1998
2
Inhibition of endothelial cell expression of plasminogen activator inhibitor type-1 by gemfibrozil. 61 54
7509512 1993
3
Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation. 61
32195632 2020
4
Acute ischemic stroke complicating common carotid artery thrombosis during a severe COVID-19 infection. 61
32389423 2020
5
Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model. 61
32205561 2020
6
Rifled carotid: Internal carotid artery thrombosis from prolonged carrying of a military rifle. 61
31133623 2019
7
Intracranial invasive mycosis mimicking hepatic encephalopathy in a patient with cirrhosis. 61
31776153 2019
8
A bacterial metabolite, trimethylamine N-oxide, disrupts the hemostasis balance in human primary endothelial cells but no coagulopathy in mice. 61
31490208 2019
9
Intracardiac Thrombosis and Multiple Arterial Thromboembolism with Acute Limb Ischemia: A Rare Complication of Carbon Monoxide Intoxication. 61
31384115 2019
10
Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice. 61
30995985 2019
11
The mode of anesthesia influences outcome in mouse models of arterial thrombosis. 61
31011704 2019
12
Anticoagulant and Antithrombotic Properties in Vitro and in Vivo of a Novel Sulfated Polysaccharide from Marine Green Alga Monostroma nitidum. 61
31027312 2019
13
Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. 61
29608550 2019
14
Antithrombotic effects and related mechanisms of Salvia deserta Schang root EtOAc extracts. 61
30532017 2018
15
The Involvement of Toll-like Receptor-2 in Arterial Thrombus Formation. 61
30261531 2018
16
Humanized GPIbα-von Willebrand factor interaction in the mouse. 61
30287479 2018
17
Rhinocerebral Mucormycosis With Temporal Artery Thrombosis in an Adolescent Following HLA-haploidentical Stem Cell Transplantation. 61
29200154 2018
18
A meta-analysis of randomized trials comparing bovine pericardium and other patch materials for carotid endarterectomy. 61
30244928 2018
19
Arterial Thrombosis Is Accompanied by Elevated Mitogen-Activated Protein Kinase (MAPK) and Cyclooxygenase-2 (COX-2) Expression via Toll-Like Receptor 4 (TLR-4) Activation by S100A8/A9. 61
30367682 2018
20
Angioedema and Hemorrhage After 4.5-Hour tPA (Tissue-Type Plasminogen Activator) Thrombolysis Ameliorated by T541 via Restoring Brain Microvascular Integrity. 61
30354988 2018
21
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury. 61
30247470 2018
22
Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging. 61
29874911 2018
23
Antiphospholipid syndrome causing reversible internal carotid artery thrombosis. 61
30070223 2018
24
Role of isopeptidolysis in the process of thrombolysis. 61
29549778 2018
25
[Abnormal structure and dysfunction of platelets in CD226 knockout mice]. 61
29973320 2018
26
Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice. 61
29421655 2018
27
Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis. 61
29097799 2017
28
PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances anti‑thrombotic effect in a rat carotid artery thrombosis model. 61
28791355 2017
29
Preventive and therapeutic effect of brozopine on stroke in Dahl Salt-sensitive hypertensive rats. 61
28760439 2017
30
Non-Vitamin K Oral Anticoagulants (NOACs) and Their Reversal. 61
28735353 2017
31
Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi. 61
28487393 2017
32
Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid β-protein precursor abolishes its anti-thrombotic properties in vivo. 61
28499154 2017
33
Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum. 61
28363953 2017
34
Platelet microparticle-inspired clot-responsive nanomedicine for targeted fibrinolysis. 61
28314136 2017
35
BDNFVal66met polymorphism: a potential bridge between depression and thrombosis. 61
26705390 2017
36
Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease-associated thrombosis in mice. 61
28264799 2017
37
Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat. 61
28487554 2017
38
Simultaneous Occurrence of Deep Vein Thrombosis and Carotid Artery Thrombosis in Antiphospholipid Antibody Syndrome. 61
28479827 2017
39
Propagation of thrombosis by neutrophils and extracellular nucleosome networks. 61
27927771 2017
40
Photoacoustic Imaging: A Novel Tool for Detecting Carotid Artery Thrombosis in Mice. 61
28689199 2017
41
The Myosin II Inhibitor, Blebbistatin, Ameliorates FeCl3-induced Arterial Thrombosis via the GSK3β-NF-κB Pathway. 61
28539835 2017
42
Studies on New Activities of Enantiomers of 2-(2-Hydroxypropanamido) Benzoic Acid: Antiplatelet Aggregation and Antithrombosis. 61
28107496 2017
43
Antithrombotic Potential of Tormentil Extract in Animal Models. 61
28860991 2017
44
Cavernous sinus thrombosis secondary to aspergillus granuloma: A case report and review of the literature. 61
26860234 2016
45
Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation. 61
27444201 2016
46
The effect of pravastatin on carotid artery thrombosis in rats under the stimulus of C-reactive protein. 61
27416543 2016
47
Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice. 61
26790499 2016
48
The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. 61
26660522 2016
49
A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation. 61
26950760 2016
50
Preparation and evaluation a new generation of low molecular weight heparin. 61
27044828 2016

Variations for Carotid Artery Thrombosis

Expression for Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for Carotid Artery Thrombosis

Pathways related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 VWF SERPINE1 SERPINC1 SELP PLAT NOS3
2
Show member pathways
11.95 VWF ITGA2B GP6 GP1BA
3 11.9 SERPINE1 PLAT NOS3
4 11.88 PLAT NOS3 ITGA2B IFNG
5 11.86 VWF SERPINE1 SERPINC1 PLAT F3 F2R
6 11.83 VWF NOS3 ITGA2B GP6 GP1BA F2R
7 11.79 SERPINE1 NOS3 IFNG
8 11.77 SERPINE1 PLAT IFNG
9 11.77 ITGA2B IFNG GP1BA CSF2
10 11.73 SERPINE1 NOS3 F3
11 11.71 ITGA2B GP1BA CSF2
12
Show member pathways
11.69 VWF ITGA2B GP1BA
13 11.64 VWF NOS3 F3
14
Show member pathways
11.48 VWF SERPINE1 SERPINC1 PLAT GP6 GP1BA
15 11.33 SELP PLAT GP1BA
16 11.33 VWF ITGA2B GP6 F2R
17 10.66 SERPINE1 PLAT
18 10.66 VWF GP6 GP1BA
19 10.49 VWF GP1BA

GO Terms for Carotid Artery Thrombosis

Cellular components related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 VWF SERPINE1 SERPINC1 PLAT IFNG F3
2 collagen-containing extracellular matrix GO:0062023 9.55 VWF SERPINE1 SERPINC1 PLAT F3
3 cell surface GO:0009986 9.43 PLAT ITGA2B GP6 GP1BA F3 F2R
4 platelet alpha granule membrane GO:0031092 9.37 SELP ITGA2B
5 extracellular space GO:0005615 9.28 SERPINE1 SERPINC1 SELP PLAT IFNG GP1BA
6 intrinsic component of external side of plasma membrane GO:0031233 9.26 F3 F10

Biological processes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.67 VWF SERPINE1 SELP ITGA2B
2 platelet activation GO:0030168 9.62 VWF GP6 GP1BA F2R
3 blood coagulation GO:0007596 9.56 VWF SERPINC1 PLAT GP6 GP1BA F3
4 macrophage differentiation GO:0030225 9.54 IFNG CSF2
5 blood coagulation, intrinsic pathway GO:0007597 9.52 VWF GP1BA
6 positive regulation of blood coagulation GO:0030194 9.51 SERPINE1 F2R
7 positive regulation of leukocyte migration GO:0002687 9.49 SELP ITGA2B
8 thrombin-activated receptor signaling pathway GO:0070493 9.48 GP1BA F2R
9 response to fluid shear stress GO:0034405 9.46 NOS3 CSF2
10 positive regulation of interleukin-23 production GO:0032747 9.43 IFNG CSF2
11 fibrinolysis GO:0042730 9.43 SERPINE1 PLAT GP1BA
12 blood coagulation, extrinsic pathway GO:0007598 9.4 F3 F10
13 regulation of blood coagulation GO:0030193 9.33 SERPINC1 GP1BA F2R
14 hemostasis GO:0007599 9.17 VWF SERPINC1 GP6 GP1BA F3 F2R

Molecular functions related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 WDTC1 VWF SERPINE1 SERPINC1 SELP PLAT
2 thrombin-activated receptor activity GO:0015057 9.16 GP1BA F2R
3 protease binding GO:0002020 8.92 VWF SERPINE1 SERPINC1 F3

Sources for Carotid Artery Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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