MCID: CRT004
MIFTS: 37

Carotid Artery Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Artery Thrombosis

MalaCards integrated aliases for Carotid Artery Thrombosis:

Name: Carotid Artery Thrombosis 12 55 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3410
MeSH 44 D002341
SNOMED-CT 68 86003009
UMLS 72 C0007274

Summaries for Carotid Artery Thrombosis

MalaCards based summary : Carotid Artery Thrombosis is related to thrombosis and mucormycosis. An important gene associated with Carotid Artery Thrombosis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include endothelial, brain and neutrophil, and related phenotypes are Increased Sindbis virus (SINV) infection and Increased Sindbis virus (SINV) infection

Related Diseases for Carotid Artery Thrombosis

Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 thrombosis 30.8 SERPINE1 PLAT F3 F10
2 mucormycosis 30.5 IFNG CSF2
3 carotid artery occlusion 30.4 NOS3 ADAMTS18
4 antiphospholipid syndrome 30.1 PLAT F3 F10
5 cerebrovascular disease 29.8 SERPINE1 PLAT ITGA2B
6 thrombocytosis 29.7 F3 CSF2
7 stroke, ischemic 29.5 SERPINE1 PLAT NOS3 F3
8 vascular disease 29.4 SERPINE1 PLAT NOS3 F3
9 myocardial infarction 27.8 SERPINE1 PLAT NOS3 ITGA2B F3 F10
10 heparin-induced thrombocytopenia 10.5 F3 F10
11 leech infestation 10.5 F3 F10
12 acquired hemophilia 10.5 F3 F10
13 vertebral artery occlusion 10.4 F3 CSF2
14 hemophilia a 10.4 F3 F10
15 large granular lymphocyte leukemia 10.4 IFNG CSF2
16 blue toe syndrome 10.4 SERPINE1 F3
17 hemophilia b 10.4 F3 F10
18 catastrophic antiphospholipid syndrome 10.4 SERPINE1 F3
19 marantic endocarditis 10.3 PLAT F3
20 factor vii deficiency 10.3 F3 F10
21 dysbaric osteonecrosis 10.3 SERPINE1 F3
22 trichosporonosis 10.3 IFNG CSF2
23 intracranial vasospasm 10.3 PLAT NOS3
24 candida glabrata 10.3 IFNG CSF2
25 human t-cell leukemia virus type 2 10.3 IFNG CSF2
26 factor xiii deficiency 10.3 SERPINE1 F3
27 meconium aspiration syndrome 10.3 IFNG CSF2
28 afibrinogenemia 10.3 F3 F10
29 lemierre's syndrome 10.3 SERPINE1 F3
30 factor x deficiency 10.3 F3 F10
31 cyclic neutropenia 10.3 IFNG CSF2
32 grange syndrome 10.3 PLAT F3
33 cytomegalovirus retinitis 10.3 IFNG CSF2
34 factor v deficiency 10.3 F3 F10
35 cryptococcal meningitis 10.3 IFNG CSF2
36 buerger disease 10.2 SERPINE1 NOS3
37 intracranial thrombosis 10.2 ITGA2B F3
38 inherited blood coagulation disease 10.2 ITGA2B F3
39 blood coagulation disease 10.2 ITGA2B F3
40 fibrinolytic defect 10.2 SERPINE1 PLAT
41 plasminogen activator inhibitor-1 deficiency 10.2 SERPINE1 PLAT
42 angina pectoris 10.2 PLAT NOS3
43 central serous chorioretinopathy 10.2 SERPINE1 PLAT
44 argentine hemorrhagic fever 10.2 SERPINE1 PLAT
45 head injury 10.2
46 intracranial hypertension 10.2 SERPINE1 F3
47 acute cor pulmonale 10.1 SERPINE1 PLAT
48 thrombophlebitis 10.1 SERPINE1 PLAT
49 acute pulmonary heart disease 10.1 SERPINE1 PLAT
50 von willebrand disease, type 2 10.1 ITGA2B F3

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to Carotid Artery Thrombosis

Symptoms & Phenotypes for Carotid Artery Thrombosis

GenomeRNAi Phenotypes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Sindbis virus (SINV) infection GR00310-A-1 9.1 CSF2 NOS3 PLAT
2 Increased Sindbis virus (SINV) infection GR00310-A-2 9.1 CSF2 NOS3 PLAT

MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 CSF2 F10 F3 IFNG ITGA2B NOS3
2 homeostasis/metabolism MP:0005376 10.06 ADAMTS18 CSF2 F10 F3 IFNG ITGA2B
3 growth/size/body region MP:0005378 10 ADAMTS18 CSF2 F3 IFNG NOS3 PLAT
4 hematopoietic system MP:0005397 9.98 CSF2 F3 IFNG ITGA2B NOS3 PLAT
5 immune system MP:0005387 9.97 ADAMTS18 CSF2 F3 IFNG ITGA2B NOS3
6 digestive/alimentary MP:0005381 9.88 ADAMTS18 IFNG ITGA2B NOS3 PLAT
7 integument MP:0010771 9.72 CSF2 F3 IFNG PLAT SERPINE1
8 reproductive system MP:0005389 9.7 ADAMTS18 CSF2 F10 IFNG ITGA2B NOS3
9 neoplasm MP:0002006 9.65 ADAMTS18 CSF2 F3 IFNG SERPINE1
10 respiratory system MP:0005388 9.5 ADAMTS18 CSF2 F3 IFNG NOS3 PLAT
11 vision/eye MP:0005391 9.02 ADAMTS18 F3 IFNG NOS3 PLAT

Drugs & Therapeutics for Carotid Artery Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy. Long-term Results Completed NCT02341196

Search NIH Clinical Center for Carotid Artery Thrombosis

Cochrane evidence based reviews: carotid artery thrombosis

Genetic Tests for Carotid Artery Thrombosis

Anatomical Context for Carotid Artery Thrombosis

MalaCards organs/tissues related to Carotid Artery Thrombosis:

41
Endothelial, Brain, Neutrophil, Myeloid, Liver, Kidney, Eye

Publications for Carotid Artery Thrombosis

Articles related to Carotid Artery Thrombosis:

(show top 50) (show all 405)
# Title Authors PMID Year
1
Antithrombotic activity of a monoclonal antibody inducing the substrate form of plasminogen activator inhibitor type 1 in rat models of venous and arterial thrombosis. 9 38
9776340 1998
2
Inhibition of endothelial cell expression of plasminogen activator inhibitor type-1 by gemfibrozil. 9 38
7509512 1993
3
Intracardiac Thrombosis and Multiple Arterial Thromboembolism with Acute Limb Ischemia: A Rare Complication of Carbon Monoxide Intoxication. 38
31384115 2019
4
Rifled carotid: Internal carotid artery thrombosis from prolonged carrying of a military rifle. 38
31133623 2019
5
The mode of anesthesia influences outcome in mouse models of arterial thrombosis. 38
31011704 2019
6
Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice. 38
30995985 2019
7
Anticoagulant and Antithrombotic Properties in Vitro and in Vivo of a Novel Sulfated Polysaccharide from Marine Green Alga Monostroma nitidum. 38
31027312 2019
8
Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. 38
29608550 2019
9
Antithrombotic effects and related mechanisms of Salvia deserta Schang root EtOAc extracts. 38
30532017 2018
10
The Involvement of Toll-like Receptor-2 in Arterial Thrombus Formation. 38
30261531 2018
11
Humanized GPIbα-von Willebrand factor interaction in the mouse. 38
30287479 2018
12
Rhinocerebral Mucormycosis With Temporal Artery Thrombosis in an Adolescent Following HLA-haploidentical Stem Cell Transplantation. 38
29200154 2018
13
A meta-analysis of randomized trials comparing bovine pericardium and other patch materials for carotid endarterectomy. 38
30244928 2018
14
Arterial Thrombosis Is Accompanied by Elevated Mitogen-Activated Protein Kinase (MAPK) and Cyclooxygenase-2 (COX-2) Expression via Toll-Like Receptor 4 (TLR-4) Activation by S100A8/A9. 38
30367682 2018
15
Angioedema and Hemorrhage After 4.5-Hour tPA (Tissue-Type Plasminogen Activator) Thrombolysis Ameliorated by T541 via Restoring Brain Microvascular Integrity. 38
30354988 2018
16
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury. 38
30247470 2018
17
Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging. 38
29874911 2018
18
Antiphospholipid syndrome causing reversible internal carotid artery thrombosis. 38
30070223 2018
19
Role of isopeptidolysis in the process of thrombolysis. 38
29549778 2018
20
[Abnormal structure and dysfunction of platelets in CD226 knockout mice]. 38
29973320 2018
21
Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice. 38
29421655 2018
22
Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis. 38
29097799 2017
23
PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances anti‑thrombotic effect in a rat carotid artery thrombosis model. 38
28791355 2017
24
Preventive and therapeutic effect of brozopine on stroke in Dahl Salt-sensitive hypertensive rats. 38
28760439 2017
25
Non-Vitamin K Oral Anticoagulants (NOACs) and Their Reversal. 38
28735353 2017
26
Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi. 38
28487393 2017
27
Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid β-protein precursor abolishes its anti-thrombotic properties in vivo. 38
28499154 2017
28
Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum. 38
28363953 2017
29
Platelet microparticle-inspired clot-responsive nanomedicine for targeted fibrinolysis. 38
28314136 2017
30
BDNFVal66met polymorphism: a potential bridge between depression and thrombosis. 38
26705390 2017
31
Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat. 38
28487554 2017
32
Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease-associated thrombosis in mice. 38
28264799 2017
33
Simultaneous Occurrence of Deep Vein Thrombosis and Carotid Artery Thrombosis in Antiphospholipid Antibody Syndrome. 38
28479827 2017
34
Propagation of thrombosis by neutrophils and extracellular nucleosome networks. 38
27927771 2017
35
Photoacoustic Imaging: A Novel Tool for Detecting Carotid Artery Thrombosis in Mice. 38
28689199 2017
36
The Myosin II Inhibitor, Blebbistatin, Ameliorates FeCl3-induced Arterial Thrombosis via the GSK3β-NF-κB Pathway. 38
28539835 2017
37
Studies on New Activities of Enantiomers of 2-(2-Hydroxypropanamido) Benzoic Acid: Antiplatelet Aggregation and Antithrombosis. 38
28107496 2017
38
Antithrombotic Potential of Tormentil Extract in Animal Models. 38
28860991 2017
39
Cavernous sinus thrombosis secondary to aspergillus granuloma: A case report and review of the literature. 38
26860234 2016
40
Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation. 38
27444201 2016
41
The effect of pravastatin on carotid artery thrombosis in rats under the stimulus of C-reactive protein. 38
27416543 2016
42
Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice. 38
26790499 2016
43
The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. 38
26660522 2016
44
A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation. 38
26950760 2016
45
Preparation and evaluation a new generation of low molecular weight heparin. 38
27044828 2016
46
Wdr1-Dependent Actin Reorganization in Platelet Activation. 38
27627652 2016
47
A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma. 38
30755874 2016
48
Angioinvasive rhinocerebral mucormycosis with complete unilateral thrombosis of internal carotid artery-case report and review of literature. 38
30363635 2016
49
Aspirin enhances protective effect of fish oil against thrombosis and injury-induced vascular remodelling. 38
25339093 2015
50
Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation. 38
26508731 2015

Variations for Carotid Artery Thrombosis

Expression for Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for Carotid Artery Thrombosis

Pathways related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.24 SERPINE1 PLAT NOS3 ITGA2B F3 F10
2
Show member pathways
12.03 SERPINE1 PLAT IFNG
3 11.81 SERPINE1 PLAT NOS3
4
Show member pathways
11.76 SERPINE1 PLAT F3 F10
5
Show member pathways
11.75 PLAT IFNG CSF2
6 11.67 ITGA2B IFNG CSF2
7 11.61 SERPINE1 PLAT IFNG
8 11.6 PLAT NOS3 ITGA2B IFNG
9 11.58 SERPINE1 NOS3 IFNG
10 11.5 SERPINE1 NOS3 F3
11 11.4 SERPINE1 PLAT F3 F10
12 11.32 SERPINE1 IFNG
13 11.3 SERPINE1 ITGA2B
14 11.22 ITGA2B CSF2
15 10.97 IFNG CSF2
16 10.57 SERPINE1 PLAT

GO Terms for Carotid Artery Thrombosis

Cellular components related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 SERPINE1 PLAT IFNG F3 F10 CSF2
2 extracellular region GO:0005576 9.5 SERPINE1 PLAT IFNG F3 F10 CSF2
3 collagen-containing extracellular matrix GO:0062023 9.43 SERPINE1 PLAT F3
4 intrinsic component of external side of plasma membrane GO:0031233 8.62 F3 F10

Biological processes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.54 PLAT F3 F10
2 hemostasis GO:0007599 9.43 F3 F10
3 positive regulation of angiogenesis GO:0045766 9.43 SERPINE1 NOS3 F3
4 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.4 SERPINE1 NOS3
5 fibrinolysis GO:0042730 9.32 SERPINE1 PLAT
6 response to fluid shear stress GO:0034405 9.16 NOS3 CSF2
7 positive regulation of interleukin-23 production GO:0032747 8.96 IFNG CSF2
8 blood coagulation, extrinsic pathway GO:0007598 8.62 F3 F10

Molecular functions related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 PLAT F3 F10

Sources for Carotid Artery Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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