MCID: CRT001
MIFTS: 27

Carotid Body Cancer

Categories: Cancer diseases, Cardiovascular diseases
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Aliases & Classifications for Carotid Body Cancer

MalaCards integrated aliases for Carotid Body Cancer:

Name: Carotid Body Cancer 11 14
Malignant Carotid Body Paraganglioma 11
Malignant Neoplasm of Carotid Body 71
Malignant Carotid Body Tumor 11
Cancer of Carotid Body 11

Classifications:



External Ids:

Disease Ontology 11 DOID:8731
ICD9CM 34 194.5
NCIt 49 C3574
SNOMED-CT 68 93740003
ICD10 31 C75.4
UMLS 71 C0153656

Summaries for Carotid Body Cancer

Disease Ontology: 11 A vascular cancer that is characterized by an encapsulated, firm round mass at the bifurcation of the common carotid artery.

MalaCards based summary: Carotid Body Cancer, also known as malignant carotid body paraganglioma, is related to paragangliomas 1 and nonsyndromic paraganglioma. An important gene associated with Carotid Body Cancer is MAP3K13 (Mitogen-Activated Protein Kinase Kinase Kinase 13), and among its related pathways/superpathways are Neuroscience and glycolysis (BioCyc). Affiliated tissues include thyroid, lymph node and brain, and related phenotype is nervous system.

Related Diseases for Carotid Body Cancer

Diseases related to Carotid Body Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 257)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 30.3 SDHD SDHB
2 nonsyndromic paraganglioma 29.9 SDHB CHGA
3 horner's syndrome 29.2 TG SYP SDHD SDHB ENO2
4 paraganglioma 28.2 TG SYP SDHD SDHB NKX2-1 ENO2
5 bladder small cell carcinoma 10.2 SYP ENO2
6 malignant melanocytic neoplasm of the peripheral nerve sheath 10.2 SYP ENO2
7 anal neuroendocrine tumor 10.2 SYP ENO2
8 neuronal intestinal dysplasia, type b 10.2 SYP ENO2
9 optic nerve astrocytoma 10.2 SYP ENO2
10 cloacogenic carcinoma 10.2 SYP ENO2
11 pineal region teratoma 10.2 SYP ENO2
12 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.2 SYP ENO2
13 bile duct mucinous adenocarcinoma 10.2 SYP ENO2
14 partial cryptophthalmia 10.2 SYP ENO2
15 intracranial primitive neuroectodermal tumor 10.2 SYP ENO2
16 cerebellopontine angle primitive neuroectodermal tumor 10.2 SYP ENO2
17 cerebellar liponeurocytoma 10.2 SYP ENO2
18 frontal lobe neoplasm 10.2 SYP ENO2
19 lipoma of spermatic cord 10.2 SYP ENO2
20 jejunal neoplasm 10.2 SYP ENO2
21 melanotic neuroectodermal tumor 10.2 SYP ENO2
22 paratesticular lipoma 10.2 SYP ENO2
23 prostate small cell carcinoma 10.2 SYP ENO2
24 perivascular tumor 10.2 SYP ENO2
25 central nervous system mesenchymal non-meningothelial tumor 10.2 SYP ENO2
26 ectomesenchymoma 10.2 SYP ENO2
27 myoblastoma 10.2 SYP ENO2
28 spinal cord oligodendroglioma 10.2 SYP ENO2
29 sinonasal undifferentiated carcinoma 10.2 SYP ENO2
30 orbital cancer 10.2 SYP ENO2
31 cerebellar medulloblastoma 10.2 SYP ENO2
32 askin's tumor 10.2 SYP ENO2
33 cystic basal cell carcinoma 10.2 SYP ENO2
34 extraosseous ewing sarcoma 10.2 SYP ENO2
35 small cell osteogenic sarcoma 10.2 SYP ENO2
36 lymphoepithelioma-like carcinoma 10.2 SYP ENO2
37 medulloepithelioma 10.2 SYP ENO2
38 cerebellum cancer 10.2 SYP ENO2
39 paranasal sinus cancer 10.2 SYP ENO2
40 cerebrovascular benign neoplasm 10.2 SYP ENO2
41 pineal gland cancer 10.2 SYP ENO2
42 endobronchial lipoma 10.2 SYP ENO2
43 embryonal tumor with multilayered rosettes, c19mc-altered 10.1 SYP ENO2
44 supratentorial primitive neuroectodermal tumor 10.1 SYP ENO2
45 extraosseous chondrosarcoma 10.1 SYP ENO2
46 differentiating neuroblastoma 10.1 SYP ENO2
47 central nervous system primitive neuroectodermal neoplasm 10.1 SYP ENO2
48 malignant teratoma 10.1 SYP ENO2
49 obstructive hydrocephalus 10.1 SYP ENO2
50 benign ependymoma 10.1 SYP ENO2

Graphical network of the top 20 diseases related to Carotid Body Cancer:



Diseases related to Carotid Body Cancer

Symptoms & Phenotypes for Carotid Body Cancer

MGI Mouse Phenotypes related to Carotid Body Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 CHGA ENO2 MAP3K13 NKX2-1 SDHD SYP

Drugs & Therapeutics for Carotid Body Cancer

Search Clinical Trials, NIH Clinical Center for Carotid Body Cancer

Genetic Tests for Carotid Body Cancer

Anatomical Context for Carotid Body Cancer

Organs/tissues related to Carotid Body Cancer:

MalaCards : Thyroid, Lymph Node, Brain

Publications for Carotid Body Cancer

Articles related to Carotid Body Cancer:

(show all 34)
# Title Authors PMID Year
1
[A case of cervical lymph node metastasis after carotid body tumor surgery]. 62
35822369 2022
2
The characteristics of carotid body tumors in high-altitude region: Analysis from a single center. 62
33813973 2022
3
Surgical outcomes and factors associated with malignancy in carotid body tumors. 62
33548423 2021
4
Metastatic Acetabular Fracture: A Rare Disease Presentation of Recurrent Head and Neck Paraganglioma. 62
32399330 2020
5
Distinct features of malignant carotid body tumors and surgical techniques for challengeable lesions: a case series of 11 patients. 62
31807890 2020
6
Malignant carotid body tumor presenting with myelopathy: case report. 62
26722959 2016
7
Persistent Asymmetric Brain MIBG Activity Related to a Cerebrovascular Infarct. 62
26571441 2016
8
[Diagnostic and therapeutic analysis of malignant carotid body tumors]. 62
24854749 2014
9
Giant malignant carotid body tumor in a 40 years old woman: a case report from Gondar University Hospital. 62
24696980 2013
10
Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy. 62
22032730 2012
11
Malignant carotid body tumor with systemic metastases. 62
21774445 2011
12
[Clinical and pathological analysis of malignant carotid body tumor]. 62
18959263 2008
13
Multiple osseous metastases of a carotid body tumor in a dog. 62
17409648 2007
14
[Surgery of the carotid artery: a retrospective study of 35 consecutive cases]. 62
16620623 2006
15
Recurrent malignant carotid body tumor: report of one case and review of the literature. 62
16313851 2005
16
Malignant carotid body tumor. 62
14999807 2004
17
Malignant carotid body tumor: a case report. 62
16027492 2004
18
[Malignant carotid paraganglioma. A case report]. 62
12916282 2003
19
Successful exclusion of a high internal carotid pseudoaneurysm using the Wallgraft endoprosthesis. 62
11907778 2002
20
Malignant carotid body tumors: report of three cases. 62
11201806 2001
21
Malignant carotid body tumor: a case report. 62
11013048 2000
22
[Lymphatic, hepatic and osseous metastasis of a carotid chemodectoma. Apropos of a case]. 62
9773002 1997
23
Characteristics, surgical management, and outcome in 17 carotid body tumors. 62
8955243 1996
24
Total internal carotid artery occlusion by a benign carotid body tumor: a rare occurrence. 62
4017612 1985
25
Metastatic carotid body paraganglioma in von Hippel-Lindau disease. An electron microscopic study. 62
6896135 1982
26
Malignant carotid body paraganglioma: light and electron microscopic study of the tumor and its metastases. 62
7448701 1980
27
Malignant carotid body tumor. 62
1158626 1975
28
Malignant carotid body tumor with extradural metastases. 62
5424534 1970
29
Canine malignant carotid body tumor. 62
5461696 1970
30
Excision of malignant carotid body tumor: resection of carotid bifurcation with autogenous vein graft. 62
5347886 1969
31
Malignant carotid body tumor. Report of a case. 62
5778136 1969
32
[Malignant carotid body tumor (chemodectoma malignium)]. 62
5710866 1968
33
Malignant carotid body tumor with mandibular involvement. Report of a case. 62
5239100 1968
34
A MALIGNANT CAROTID BODY TUMOR IN AN AFRICAN. 62
14068964 1963

Variations for Carotid Body Cancer

Expression for Carotid Body Cancer

Search GEO for disease gene expression data for Carotid Body Cancer.

Pathways for Carotid Body Cancer

Pathways related to Carotid Body Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.86 SYP NKX2-1 ENO2
2
Show member pathways
11.46 SDHD SDHB ENO2
3
Show member pathways
9.7 SDHD SDHB

GO Terms for Carotid Body Cancer

Cellular components related to Carotid Body Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHB

Biological processes related to Carotid Body Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 9.26 TG NKX2-1
2 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHD SDHB

Molecular functions related to Carotid Body Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 9.26 SDHD SDHB
2 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.92 SDHD SDHB

Sources for Carotid Body Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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