MCID: CRT001
MIFTS: 27

Carotid Body Cancer

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Carotid Body Cancer

MalaCards integrated aliases for Carotid Body Cancer:

Name: Carotid Body Cancer 12 15
Malignant Carotid Body Paraganglioma 12
Malignant Neoplasm of Carotid Body 70
Malignant Carotid Body Tumor 12
Cancer of Carotid Body 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8731
ICD9CM 34 194.5
NCIt 50 C3574
SNOMED-CT 67 93740003
ICD10 32 C75.4
UMLS 70 C0153656

Summaries for Carotid Body Cancer

Disease Ontology : 12 A vascular cancer that is characterized by an encapsulated, firm round mass at the bifurcation of the common carotid artery.

MalaCards based summary : Carotid Body Cancer, also known as malignant carotid body paraganglioma, is related to paraganglioma and paragangliomas 1. An important gene associated with Carotid Body Cancer is ENO2 (Enolase 2), and among its related pathways/superpathways is Neuroscience. Affiliated tissues include thyroid, lung and pineal, and related phenotype is nervous system.

Related Diseases for Carotid Body Cancer

Diseases related to Carotid Body Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 paraganglioma 28.9 TG SYP SST ENO2 CHGA CALCA
2 paragangliomas 1 10.4
3 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
4 optic nerve astrocytoma 10.3 SYP ENO2
5 cerebral neuroblastoma 10.3 SYP ENO2
6 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
7 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
8 papillary tumor of the pineal region 10.3 SYP ENO2
9 cloacogenic carcinoma 10.3 SYP ENO2
10 pineal region teratoma 10.3 SYP ENO2
11 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
12 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
13 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
14 nodular prostate 10.3 SYP ENO2
15 cerebellar liponeurocytoma 10.3 SYP ENO2
16 ganglioneuroblastoma 10.3 SYP ENO2
17 cerebellopontine angle primitive neuroectodermal tumor 10.3 SYP ENO2
18 jejunal neoplasm 10.3 SYP ENO2
19 frontal lobe neoplasm 10.3 SYP ENO2
20 mature teratoma 10.3 SYP ENO2
21 myoblastoma 10.3 SYP ENO2
22 pineal parenchymal tumor of intermediate differentiation 10.3 SYP ENO2
23 kidney rhabdoid cancer 10.3 SYP ENO2
24 spinal cord oligodendroglioma 10.3 SYP ENO2
25 endobronchial leiomyoma 10.3 SYP ENO2
26 orbital cancer 10.2 SYP ENO2
27 extraosseous ewing sarcoma 10.2 SYP ENO2
28 small cell osteogenic sarcoma 10.2 SYP ENO2
29 endobronchial lipoma 10.2 SYP ENO2
30 rhabdoid meningioma 10.2 SYP ENO2
31 thymus basaloid carcinoma 10.2 SYP NKX2-1
32 bladder lateral wall cancer 10.2 SYP ENO2
33 cerebrovascular benign neoplasm 10.2 SYP ENO2
34 cerebellum cancer 10.2 SYP ENO2
35 cerebellar medulloblastoma 10.2 SYP ENO2
36 askin's tumor 10.2 SYP ENO2
37 vaginal glandular tumor 10.2 ENO2 CHGA
38 clear cell ependymoma 10.2 SYP ENO2
39 ureter transitional cell carcinoma 10.2 ENO2 CHGA
40 pineal gland cancer 10.2 SYP ENO2
41 cystic basal cell carcinoma 10.2 SYP ENO2
42 gangliocytoma 10.2 SYP ENO2
43 central nervous system primitive neuroectodermal neoplasm 10.2 SYP ENO2
44 gastric gastrinoma 10.2 ENO2 CHGA
45 ependymoblastoma 10.2 SYP ENO2
46 extraosseous chondrosarcoma 10.2 SYP ENO2
47 cystadenoma 10.2 SYP CHGA
48 subleukemic leukemia 10.2 SYP ENO2
49 nodular ganglioneuroblastoma 10.2 ENO2 CHGA
50 ovarian small cell carcinoma 10.2 SYP ENO2

Graphical network of the top 20 diseases related to Carotid Body Cancer:



Diseases related to Carotid Body Cancer

Symptoms & Phenotypes for Carotid Body Cancer

MGI Mouse Phenotypes related to Carotid Body Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 CHGA ENO2 NKX2-1 SST SYP TG

Drugs & Therapeutics for Carotid Body Cancer

Search Clinical Trials , NIH Clinical Center for Carotid Body Cancer

Genetic Tests for Carotid Body Cancer

Anatomical Context for Carotid Body Cancer

MalaCards organs/tissues related to Carotid Body Cancer:

40
Thyroid, Lung, Pineal, Thymus, Breast, Appendix, Bone

Publications for Carotid Body Cancer

Articles related to Carotid Body Cancer:

(show all 26)
# Title Authors PMID Year
1
Surgical outcomes and factors associated with malignancy in carotid body tumors. 61
33548423 2021
2
Distinct features of malignant carotid body tumors and surgical techniques for challengeable lesions: a case series of 11 patients. 61
31807890 2020
3
Malignant carotid body tumor presenting with myelopathy: case report. 61
26722959 2016
4
[Diagnostic and therapeutic analysis of malignant carotid body tumors]. 61
24854749 2014
5
Giant malignant carotid body tumor in a 40 years old woman: a case report from Gondar University Hospital. 61
24696980 2013
6
Malignant carotid body tumor with systemic metastases. 61
21774445 2011
7
[Clinical and pathological analysis of malignant carotid body tumor]. 61
18959263 2008
8
Multiple osseous metastases of a carotid body tumor in a dog. 61
17409648 2007
9
[Surgery of the carotid artery: a retrospective study of 35 consecutive cases]. 61
16620623 2006
10
Recurrent malignant carotid body tumor: report of one case and review of the literature. 61
16313851 2005
11
Malignant carotid body tumor. 61
14999807 2004
12
Malignant carotid body tumor: a case report. 61
16027492 2004
13
Successful exclusion of a high internal carotid pseudoaneurysm using the Wallgraft endoprosthesis. 61
11907778 2002
14
Malignant carotid body tumors: report of three cases. 61
11201806 2001
15
Malignant carotid body tumor: a case report. 61
11013048 2000
16
[Lymphatic, hepatic and osseous metastasis of a carotid chemodectoma. Apropos of a case]. 61
9773002 1997
17
Characteristics, surgical management, and outcome in 17 carotid body tumors. 61
8955243 1996
18
Total internal carotid artery occlusion by a benign carotid body tumor: a rare occurrence. 61
4017612 1985
19
Malignant carotid body tumor. 61
1158626 1975
20
Malignant carotid body tumor with extradural metastases. 61
5424534 1970
21
Canine malignant carotid body tumor. 61
5461696 1970
22
Excision of malignant carotid body tumor: resection of carotid bifurcation with autogenous vein graft. 61
5347886 1969
23
Malignant carotid body tumor. Report of a case. 61
5778136 1969
24
[Malignant carotid body tumor (chemodectoma malignium)]. 61
5710866 1968
25
Malignant carotid body tumor with mandibular involvement. Report of a case. 61
5239100 1968
26
A MALIGNANT CAROTID BODY TUMOR IN AN AFRICAN. 61
14068964 1963

Variations for Carotid Body Cancer

Expression for Carotid Body Cancer

Search GEO for disease gene expression data for Carotid Body Cancer.

Pathways for Carotid Body Cancer

Pathways related to Carotid Body Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SYP NKX2-1 ENO2 CALCA

GO Terms for Carotid Body Cancer

Cellular components related to Carotid Body Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 VWF TG SST ENO2 CHGA CALCA
2 terminal bouton GO:0043195 8.96 SYP CALCA

Biological processes related to Carotid Body Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to heat GO:0009408 8.96 SST CALCA
2 thyroid gland development GO:0030878 8.62 TG NKX2-1

Molecular functions related to Carotid Body Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 TG SST CALCA

Sources for Carotid Body Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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