Carotid Body Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Carotid Body Cancer, also known as malignant carotid body paraganglioma, is related to paragangliomas 1 and nonsyndromic paraganglioma. An important gene associated with Carotid Body Cancer is MAP3K13 (Mitogen-Activated Protein Kinase Kinase Kinase 13), and among its related pathways/superpathways are Neuroscience and glycolysis (BioCyc). Affiliated tissues include thyroid, lymph node and brain, and related phenotype is nervous system.

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Related Diseases for Carotid Body Cancer

Diseases related to Carotid Body Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 257)

#	Related Disease	Score	Top Affiliating Genes
1	paragangliomas 1	30.3	SDHD SDHB
2	nonsyndromic paraganglioma	29.9	SDHB CHGA
3	horner's syndrome	29.2	TG SYP SDHD SDHB ENO2
4	paraganglioma	28.2	TG SYP SDHD SDHB NKX2-1 ENO2
5	bladder small cell carcinoma	10.2	SYP ENO2
6	malignant melanocytic neoplasm of the peripheral nerve sheath	10.2	SYP ENO2
7	anal neuroendocrine tumor	10.2	SYP ENO2
8	neuronal intestinal dysplasia, type b	10.2	SYP ENO2
9	optic nerve astrocytoma	10.2	SYP ENO2
10	cloacogenic carcinoma	10.2	SYP ENO2
11	pineal region teratoma	10.2	SYP ENO2
12	extraosseous ewings sarcoma-primitive neuroepithelial tumor	10.2	SYP ENO2
13	bile duct mucinous adenocarcinoma	10.2	SYP ENO2
14	partial cryptophthalmia	10.2	SYP ENO2
15	intracranial primitive neuroectodermal tumor	10.2	SYP ENO2
16	cerebellopontine angle primitive neuroectodermal tumor	10.2	SYP ENO2
17	cerebellar liponeurocytoma	10.2	SYP ENO2
18	frontal lobe neoplasm	10.2	SYP ENO2
19	lipoma of spermatic cord	10.2	SYP ENO2
20	jejunal neoplasm	10.2	SYP ENO2
21	melanotic neuroectodermal tumor	10.2	SYP ENO2
22	paratesticular lipoma	10.2	SYP ENO2
23	prostate small cell carcinoma	10.2	SYP ENO2
24	perivascular tumor	10.2	SYP ENO2
25	central nervous system mesenchymal non-meningothelial tumor	10.2	SYP ENO2
26	ectomesenchymoma	10.2	SYP ENO2
27	myoblastoma	10.2	SYP ENO2
28	spinal cord oligodendroglioma	10.2	SYP ENO2
29	sinonasal undifferentiated carcinoma	10.2	SYP ENO2
30	orbital cancer	10.2	SYP ENO2
31	cerebellar medulloblastoma	10.2	SYP ENO2
32	askin's tumor	10.2	SYP ENO2
33	cystic basal cell carcinoma	10.2	SYP ENO2
34	extraosseous ewing sarcoma	10.2	SYP ENO2
35	small cell osteogenic sarcoma	10.2	SYP ENO2
36	lymphoepithelioma-like carcinoma	10.2	SYP ENO2
37	medulloepithelioma	10.2	SYP ENO2
38	cerebellum cancer	10.2	SYP ENO2
39	paranasal sinus cancer	10.2	SYP ENO2
40	cerebrovascular benign neoplasm	10.2	SYP ENO2
41	pineal gland cancer	10.2	SYP ENO2
42	endobronchial lipoma	10.2	SYP ENO2
43	embryonal tumor with multilayered rosettes, c19mc-altered	10.1	SYP ENO2
44	supratentorial primitive neuroectodermal tumor	10.1	SYP ENO2
45	extraosseous chondrosarcoma	10.1	SYP ENO2
46	differentiating neuroblastoma	10.1	SYP ENO2
47	central nervous system primitive neuroectodermal neoplasm	10.1	SYP ENO2
48	malignant teratoma	10.1	SYP ENO2
49	obstructive hydrocephalus	10.1	SYP ENO2
50	benign ependymoma	10.1	SYP ENO2

Graphical network of the top 20 diseases related to Carotid Body Cancer:

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Symptoms & Phenotypes for Carotid Body Cancer

MGI Mouse Phenotypes related to Carotid Body Cancer:

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#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.17	CHGA ENO2 MAP3K13 NKX2-1 SDHD SYP

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Drugs & Therapeutics for Carotid Body Cancer

Search Clinical Trials, NIH Clinical Center for Carotid Body Cancer

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Genetic Tests for Carotid Body Cancer

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Anatomical Context for Carotid Body Cancer

Organs/tissues related to Carotid Body Cancer:

MalaCards : Thyroid, Lymph Node, Brain

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Publications for Carotid Body Cancer

Articles related to Carotid Body Cancer:

(show all 34)

#	Title	Authors	PMID	Year
1	[A case of cervical lymph node metastasis after carotid body tumor surgery]. ⁶²	Lv H...Wang Z	35822369	2022
2	The characteristics of carotid body tumors in high-altitude region: Analysis from a single center. ⁶²	Wang YH...Wu JY	33813973	2022
3	Surgical outcomes and factors associated with malignancy in carotid body tumors. ⁶²	Zhang W...Fu W	33548423	2021
4	Metastatic Acetabular Fracture: A Rare Disease Presentation of Recurrent Head and Neck Paraganglioma. ⁶²	Patchana T...Gnass RD	32399330	2020
5	Distinct features of malignant carotid body tumors and surgical techniques for challengeable lesions: a case series of 11 patients. ⁶²	Gu G...Zheng Y	31807890	2020
6	Malignant carotid body tumor presenting with myelopathy: case report. ⁶²	Jeevan DS...Hillard VH	26722959	2016
7	Persistent Asymmetric Brain MIBG Activity Related to a Cerebrovascular Infarct. ⁶²	Bai X...Zhuang H	26571441	2016
8	[Diagnostic and therapeutic analysis of malignant carotid body tumors]. ⁶²	Lian L...Li Y	24854749	2014
9	Giant malignant carotid body tumor in a 40 years old woman: a case report from Gondar University Hospital. ⁶²	Amsalu A...Tesfaye W	24696980	2013
10	Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy. ⁶²	Williamson J...Ingrams D	22032730	2012
11	Malignant carotid body tumor with systemic metastases. ⁶²	Nishijima H...Sugasawa M	21774445	2011
12	[Clinical and pathological analysis of malignant carotid body tumor]. ⁶²	Zhang WC...Wu YS	18959263	2008
13	Multiple osseous metastases of a carotid body tumor in a dog. ⁶²	Okajima M...Nishida K	17409648	2007
14	[Surgery of the carotid artery: a retrospective study of 35 consecutive cases]. ⁶²	Zhang ZY...Fan XD	16620623	2006
15	Recurrent malignant carotid body tumor: report of one case and review of the literature. ⁶²	Zheng JW...Zhang ZY	16313851	2005
16	Malignant carotid body tumor. ⁶²	Carroll W...Stringer S	14999807	2004
17	Malignant carotid body tumor: a case report. ⁶²	Uguz MZ...Gokce H	16027492	2004
18	[Malignant carotid paraganglioma. A case report]. ⁶²	Righini Ch...Reyt E	12916282	2003
19	Successful exclusion of a high internal carotid pseudoaneurysm using the Wallgraft endoprosthesis. ⁶²	Ellis PK...Barros D'Sa AA	11907778	2002
20	Malignant carotid body tumors: report of three cases. ⁶²	Pacheco-Ojeda L	11201806	2001
21	Malignant carotid body tumor: a case report. ⁶²	Dias Da Silva A...Rich N	11013048	2000
22	[Lymphatic, hepatic and osseous metastasis of a carotid chemodectoma. Apropos of a case]. ⁶²	Defraigne JO...Limet R	9773002	1997
23	Characteristics, surgical management, and outcome in 17 carotid body tumors. ⁶²	Mitchell RO...Lambert GE	8955243	1996
24	Total internal carotid artery occlusion by a benign carotid body tumor: a rare occurrence. ⁶²	Sacher M...Biller HF	4017612	1985
25	Metastatic carotid body paraganglioma in von Hippel-Lindau disease. An electron microscopic study. ⁶²	Hull MT...Walker PD	6896135	1982
26	Malignant carotid body paraganglioma: light and electron microscopic study of the tumor and its metastases. ⁶²	Robertson DI...Cooney TP	7448701	1980
27	Malignant carotid body tumor. ⁶²	Martinson FD	1158626	1975
28	Malignant carotid body tumor with extradural metastases. ⁶²	Whimster WF...Masson AF	5424534	1970
29	Canine malignant carotid body tumor. ⁶²	Sander CH...Whitenack DL	5461696	1970
30	Excision of malignant carotid body tumor: resection of carotid bifurcation with autogenous vein graft. ⁶²	Jones EW...Gonzalez LL	5347886	1969
31	Malignant carotid body tumor. Report of a case. ⁶²	Bestler JM...Toomey JM	5778136	1969
32	[Malignant carotid body tumor (chemodectoma malignium)]. ⁶²	Stanulla H...Stanulla A	5710866	1968
33	Malignant carotid body tumor with mandibular involvement. Report of a case. ⁶²	Werner PE...McSwain B	5239100	1968
34	A MALIGNANT CAROTID BODY TUMOR IN AN AFRICAN. ⁶²	HUTT MS...MODY NJ	14068964	1963

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Genes for Carotid Body Cancer

Genes related to Carotid Body Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MAP3K13	Mitogen-Activated Protein Kinase Kinase Kinase 13	Protein Coding	5.8	DISEASES inferred ¹⁴
2	SYP	Synaptophysin	Protein Coding	5.41	DISEASES inferred ¹⁴
3	ENO2	Enolase 2	Protein Coding	5.33	DISEASES inferred ¹⁴
4	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	5.07	DISEASES inferred ¹⁴
5	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	4.64	DISEASES inferred ¹⁴
6	NKX2-1	NK2 Homeobox 1	Protein Coding	3.27	DISEASES inferred ¹⁴
7	CHGA	Chromogranin A	Protein Coding	3.08	DISEASES inferred ¹⁴
8	TG	Thyroglobulin	Protein Coding	2.97	DISEASES inferred ¹⁴

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Variations for Carotid Body Cancer

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Expression for Carotid Body Cancer

Search GEO for disease gene expression data for Carotid Body Cancer.

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Pathways for Carotid Body Cancer

Pathways related to Carotid Body Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ³	11.86	SYP NKX2-1 ENO2
2	glycolysis (BioCyc) ⁶¹ Show member pathways Aerobic glycolysis ⁷⁴ glycolysis ⁶¹ Glycolysis and gluconeogenesis ⁷⁴ Glycolysis and gluconeogenesis (short map) ²² glycolysis III (from glucose) ⁶¹ homolactic fermentation ⁶¹ Manipulation of host energy metabolism ⁶⁶	11.46	SDHD SDHB ENO2
3	Mitochondrial complex II assembly ⁷⁴ Show member pathways aerobic respiration I (cytochrome c) ⁶¹	9.7	SDHD SDHB

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GO Terms for Carotid Body Cancer

Cellular components related to Carotid Body Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.92	SDHD SDHB

Biological processes related to Carotid Body Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	thyroid gland development	GO:0030878	9.26	TG NKX2-1
2	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	8.92	SDHD SDHB

Molecular functions related to Carotid Body Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ubiquinone binding	GO:0048039	9.26	SDHD SDHB
2	succinate dehydrogenase (ubiquinone) activity	GO:0008177	8.92	SDHD SDHB

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Sources for Carotid Body Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CRT001 MIFTS: 27	Carotid Body Cancer Categories: Cancer diseases, Cardiovascular diseases	Data Licensing For inquiries, contact: [email protected]
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