CIMT2
MCID: CRT085
MIFTS: 24

Carotid Intimal Medial Thickness 2 (CIMT2)

Categories: Genetic diseases

Aliases & Classifications for Carotid Intimal Medial Thickness 2

MalaCards integrated aliases for Carotid Intimal Medial Thickness 2:

Name: Carotid Intimal Medial Thickness 2 56 71
Carotid Intimal Medial Thickness 56 13
Carotid Intimal Medial Thickness Quantitative Trait Locus on Chromosome 12 56
Cimt2 56

Classifications:



External Ids:

OMIM 56 608447
UMLS 71 C1838020

Summaries for Carotid Intimal Medial Thickness 2

MalaCards based summary : Carotid Intimal Medial Thickness 2, also known as carotid intimal medial thickness, is related to carotid intimal medial thickness 1 and glucose intolerance. An important gene associated with Carotid Intimal Medial Thickness 2 is CIMT (Carotid Intimal Medial Thickness). The drugs Progesterone and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney.

More information from OMIM: 608447

Related Diseases for Carotid Intimal Medial Thickness 2

Graphical network of the top 20 diseases related to Carotid Intimal Medial Thickness 2:



Diseases related to Carotid Intimal Medial Thickness 2

Symptoms & Phenotypes for Carotid Intimal Medial Thickness 2

Clinical features from OMIM:

608447

Drugs & Therapeutics for Carotid Intimal Medial Thickness 2

Drugs for Carotid Intimal Medial Thickness 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Polyestradiol phosphate Approved Phase 4 28014-46-2
4 Estradiol 17 beta-cypionate Phase 4
5 Progestins Phase 4
6 Hormone Antagonists Phase 4
7 Estradiol 3-benzoate Phase 4
8 Estrogens Phase 4
9 Contraceptive Agents Phase 4
10 Estrogens, Conjugated (USP) Phase 4
11
Simvastatin Approved Phase 3 79902-63-9 54454
12 Angiotensin-Converting Enzyme Inhibitors Phase 3
13 HIV Protease Inhibitors Phase 3
14 Lipid Regulating Agents Phase 3
15
protease inhibitors Phase 3
16 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
17 Anticholesteremic Agents Phase 3
18 Hypolipidemic Agents Phase 3
19 Antimetabolites Phase 3
20
Liraglutide Approved 204656-20-2 44147092
21
chloroquine Approved, Investigational, Vet_approved 54-05-7 2719
22 Nutrients
23 Anti-Infective Agents
24 Chloroquine diphosphate 50-63-5
25 Antiparasitic Agents
26 Amebicides
27 Antiprotozoal Agents
28 Antirheumatic Agents
29 Antimalarials
30 Hormones

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Effects of Estrogen Replacement on Atherosclerosis Progression in Recently Menopausal Women Unknown status NCT00154180 Phase 4 Conjugated equine estrogens 0.45 mg/day;Transdermal estradiol, 50 mcg/day;Micronized progesterone, 200 mg/day x 12 d/month;CEE , progesterone, estradiol patch or placebo for each;CEE, progesterone, transdermal patch or the placebo
2 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
3 Stop Atherosclerosis in Native Diabetics Study (SANDS) Completed NCT00047424 Phase 3 simvastatin;ACE inhibitors
4 A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese Unknown status NCT01208116
5 Fat Redistribution and Metabolic Change in HIV Infection (FRAM) Unknown status NCT00331448
6 Epidemiology of Carotid Artery Atherosclerosis in Youth Completed NCT00005397
7 Ultrasound Assessment of the Carotid Intimal Medial Thickness in Obese Subjects Following a Significant Weight Loss Completed NCT02954627
8 Progression of Sub-Clinical Atherosclerosis Completed NCT00241787
9 Molecular Epidemiology of Myocardial Infarction and Stroke in Older Adults - Ancillary to CHS Completed NCT00078429
10 Coronary Calcification Progression Study Completed NCT00006526
11 CV Disease in Adolescents With Type 2 Diabetes Completed NCT00114998
12 Atherosclerosis, Plaque and CVD in Communities Completed NCT00091754
13 San Diego Partnership to Reduce Diabetes & Cardiovascular Disease in Latinos Completed NCT02955238
14 Genotoxic Stress, Atherosclerosis, and Metabolic Syndrome- Aim 3 Completed NCT00455403 Chloroquine;Placebo Comparator
15 Assessment of Cardiovascular Risk Markers in GH Deficient Patients With Nonsecreting Pituitary Adenomas Terminated NCT00646308

Search NIH Clinical Center for Carotid Intimal Medial Thickness 2

Genetic Tests for Carotid Intimal Medial Thickness 2

Anatomical Context for Carotid Intimal Medial Thickness 2

MalaCards organs/tissues related to Carotid Intimal Medial Thickness 2:

40
Heart, Endothelial, Kidney, Pituitary, Liver, Bone, Breast

Publications for Carotid Intimal Medial Thickness 2

Articles related to Carotid Intimal Medial Thickness 2:

(show top 50) (show all 194)
# Title Authors PMID Year
1
Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12. 61 56
14730480 2004
2
Small Dense Low-Density Lipoprotein Cholesterol and Carotid Intimal Medial Thickness Progression. 61
32281547 2020
3
Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib. 61
32087417 2020
4
Interactive Relations Across Dimensions of Interpersonal-Level Discrimination and Depressive Symptoms to Carotid Intimal-Medial Thickening in African Americans. 61
31738316 2020
5
Correlative Study of HbA1c in Non Diabetic NAFLD with Carotid Intimal Medial Thickness and Abdominal Fat Indices. 61
31979805 2020
6
Osteopontin for Early Detection of Microvascular and Macrovascular Type 1 Diabetic Complication. 61
32010387 2019
7
Comparison between central and ambulatory blood pressure measurements in early detection of end organ damage: a single-center prospective non-randomized controlled trial. 61
31659522 2019
8
Association of serum proprotein convertase subtilisin/kexin type 9 with early atherosclerosis in newly diagnosed type 2 diabetes mellitus. 61
31133497 2019
9
The effectiveness of high-resolution ultrasound in the assessment of the carotid intima-media thickness for postirradiated neck. 61
30683992 2019
10
The Utility of the Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Assay in Detecting Abnormalities in Lipid Metabolism and Cardiovascular Risk in an HIV-Infected South African Cohort. 61
31686546 2019
11
PeRiodontal Treatment to Eliminate Minority Inequality and Rural Disparities in Stroke (PREMIERS): A Multicenter, Randomized, Controlled Study. 61
32159164 2019
12
Aortic, carotid intima-media thickness and flow- mediated dilation as markers of early atherosclerosis in a cohort of pediatric patients with rheumatic diseases. 61
29022136 2018
13
Late-Life Depressive Symptoms as Partial Mediators in the Associations between Subclinical Cardiovascular Disease with Onset of Mild Cognitive Impairment and Dementia. 61
29254675 2018
14
Target Organ Damage and Target Systolic Blood Pressure in Clinical Practice: The Campania Salute Network. 61
29566163 2018
15
No Association of Genetic Markers with Carotid Intimal Medial Thickness in β-Thalassemia Major Patients. 61
29441217 2018
16
Markers of subclinical atherosclerotic disease in HIV-infected individuals. 61
29568549 2018
17
Study of carotid intimal medial thickness in essential hypertension with or without left ventricular hypertrophy. 61
29063904 2017
18
Residual atherosclerotic cardiovascular disease risk in statin-treated adults: The Multi-Ethnic Study of Atherosclerosis. 61
28754224 2017
19
Carotid atherosclerosis promotes the progression of Alzheimer's disease: A three-year prospective study. 61
28810593 2017
20
Association between dairy intake, lipids and vascular structure and function in diabetes. 61
28572881 2017
21
Distributions of Subclinical Cardiovascular Disease in a Socioeconomically and Racially Diverse Sample. 61
28235961 2017
22
Chronic kidney disease - determinants of progression and cardiovascular risk. PROGREDIR cohort study: design and methods. 61
28443950 2017
23
Cardiovascular Health among Black and White Breast Cancer Patients Initiating Aromatase Inhibitor Therapy. 61
27779346 2017
24
Hepatic steatosis is associated with cardiometabolic risk in a rural Indian population: A prospective cohort study. 61
27723535 2016
25
Assessment of Increase in Aortic and Carotid Intimal Medial Thickness in Type 1 Diabetic Patients. 61
28028403 2016
26
Subclinical carotid atherosclerosis and neurocognitive function in an urban population. 61
27092741 2016
27
Development and Validation of Risk Prediction Models for Cardiovascular Events in Black Adults: The Jackson Heart Study Cohort. 61
27437649 2016
28
Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years. 61
26940919 2016
29
Nonalcoholic fatty liver disease and carotid artery atherosclerosis in children and adults: a meta-analysis. 61
26193052 2015
30
Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes. 61
25968430 2015
31
The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada. 61
26239008 2015
32
The expression of p66shc in peripheral blood monocytes is increased in patients with coronary heart disease and correlated with endothelium-dependent vasodilatation. 61
24676406 2015
33
Association between red blood cell distribution width (RDW) and carotid artery atherosclerosis (CAS) in patients with primary ischemic stroke. 61
25957866 2015
34
Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. 61
25271088 2015
35
Effects of age and smoking on endothelial function assessed by quantitative cardiovascular magnetic resonance in the peripheral and central vasculature. 61
25884943 2015
36
Meta-analysis of the effects of lifestyle modifications on coronary and carotid atherosclerotic burden. 61
25465939 2015
37
An evaluation of coronary atherosclerosis using coronary CT in subjects with asymptomatic carotid lesions. 61
25147763 2014
38
Is There Any Relationship between Joint Destruction and Carotid Intima-media Thickness in Patients with Rheumatoid Arthritis? 61
25140104 2014
39
Correlation of carotid intimal-medial thickness with estimated glomerular filtration rate and cardiovascular risk factors in chronic kidney disease. 61
24821154 2014
40
Potential anti-atherosclerotic effects of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus. 61
24390468 2014
41
Comparison of carotid intima-media thickness in pediatric patients with metabolic syndrome, heterozygous familial hyperlipidemia and normals. 61
24955251 2014
42
Correlation of serum phosphate with carotid intimal-medial thickness in chronic kidney disease patients. 61
24574625 2014
43
Effects of GH on body composition and cardiovascular risk markers in young men with abdominal obesity. 61
23824419 2013
44
The relationship between pediatric nonalcoholic fatty liver disease and cardiovascular risk factors and increased risk of atherosclerosis in obese children. 61
22875138 2013
45
Low Bone Mass is Associated with Increased Carotid Intima Media Thickness in Men with Type 2 Diabetes Mellitus. 61
23861625 2013
46
Bone Mineral Density as a Predictor of Atherosclerosis and Arterial Wall Stiffness in Obese African-American Women. 61
23381741 2012
47
Carotid atherosclerosis and prospective risk of dementia. 61
23103489 2012
48
Association of glycated hemoglobin with carotid intimal medial thickness in Asian Indians with normal glucose tolerance. 61
22795336 2012
49
Endothelial Function and Carotid Intimal Medial Thickness in Asymptomatic Subjects With and Without Cardiovascular Risk Factors. 61
28348684 2012
50
Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: the multi-ethnic study of atherosclerosis. 61
22628436 2012

Variations for Carotid Intimal Medial Thickness 2

Expression for Carotid Intimal Medial Thickness 2

Search GEO for disease gene expression data for Carotid Intimal Medial Thickness 2.

Pathways for Carotid Intimal Medial Thickness 2

GO Terms for Carotid Intimal Medial Thickness 2

Sources for Carotid Intimal Medial Thickness 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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