CIMT2
MCID: CRT085
MIFTS: 25

Carotid Intimal Medial Thickness 2 (CIMT2)

Categories: Genetic diseases

Aliases & Classifications for Carotid Intimal Medial Thickness 2

MalaCards integrated aliases for Carotid Intimal Medial Thickness 2:

Name: Carotid Intimal Medial Thickness 2 58 74
Carotid Intimal Medial Thickness 58 13
Carotid Intimal Medial Thickness Quantitative Trait Locus on Chromosome 12 58
Cimt2 58

Classifications:



External Ids:

OMIM 58 608447
UMLS 74 C1838020

Summaries for Carotid Intimal Medial Thickness 2

MalaCards based summary : Carotid Intimal Medial Thickness 2, also known as carotid intimal medial thickness, is related to carotid intimal medial thickness 1 and hypertension, essential. An important gene associated with Carotid Intimal Medial Thickness 2 is CIMT (Carotid Intimal Medial Thickness). The drugs Probucol and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and endothelial.

Description from OMIM: 608447

Related Diseases for Carotid Intimal Medial Thickness 2

Diseases in the Carotid Intimal Medial Thickness 1 family:

Carotid Intimal Medial Thickness 2

Diseases related to Carotid Intimal Medial Thickness 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 carotid intimal medial thickness 1 12.8
2 hypertension, essential 10.3
3 diabetes mellitus 10.3
4 diabetes mellitus, noninsulin-dependent 10.3
5 chronic kidney failure 10.3
6 glucose intolerance 10.3
7 kidney disease 10.3
8 arteries, anomalies of 10.1
9 systemic lupus erythematosus 10.1
10 aging 10.1
11 coronary heart disease 1 10.1
12 muscle hypertrophy 10.1
13 coronary artery anomaly 10.1
14 thalassemia 10.1
15 heart disease 10.1
16 gestational diabetes 10.1
17 vascular disease 10.1
18 lupus erythematosus 10.1

Graphical network of the top 20 diseases related to Carotid Intimal Medial Thickness 2:



Diseases related to Carotid Intimal Medial Thickness 2

Symptoms & Phenotypes for Carotid Intimal Medial Thickness 2

Clinical features from OMIM:

608447

Drugs & Therapeutics for Carotid Intimal Medial Thickness 2

Drugs for Carotid Intimal Medial Thickness 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Probucol Approved, Investigational Phase 4 23288-49-5 4912
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
4
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
5
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
6
Polyestradiol phosphate Approved Phase 4 28014-46-2
7
Atorvastatin Approved Phase 4 134523-00-5 60823
8 Neuroprotective Agents Phase 4
9 Anticholesteremic Agents Phase 4
10 Antioxidants Phase 4,Phase 2,Phase 3
11 Peripheral Nervous System Agents Phase 4
12 Platelet Aggregation Inhibitors Phase 4
13 Autonomic Agents Phase 4
14 Bronchodilator Agents Phase 4
15 Antipyretics Phase 4
16 Analgesics Phase 4
17 Analgesics, Non-Narcotic Phase 4
18 Phosphodiesterase 3 Inhibitors Phase 4
19 Respiratory System Agents Phase 4
20 Phosphodiesterase Inhibitors Phase 4
21 Fibrinolytic Agents Phase 4
22 Anti-Asthmatic Agents Phase 4
23 Cyclooxygenase Inhibitors Phase 4
24 Vasodilator Agents Phase 4
25 Hypolipidemic Agents Phase 4
26 Antimetabolites Phase 4,Phase 2
27 Antirheumatic Agents Phase 4
28 Protective Agents Phase 4,Phase 2,Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4
30 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
31 Lipid Regulating Agents Phase 4
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
33 Contraceptive Agents Phase 4
34 Estrogens Phase 4
35 Progestins Phase 4
36 Hormones Phase 4,Not Applicable
37 Hormone Antagonists Phase 4,Not Applicable
38 Estradiol 3-benzoate Phase 4
39 Estradiol 17 beta-cypionate Phase 4
40 Estrogens, Conjugated (USP) Phase 4
41 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
42 Lycopene Approved, Investigational Phase 2, Phase 3 502-65-8 53477748
43
Rosiglitazone Approved, Investigational Phase 3 122320-73-4 77999
44
Ramipril Approved Phase 3 87333-19-5 5362129
45
Lutein Approved, Investigational, Nutraceutical Phase 2, Phase 3 127-40-2 6433159
46 Radiation-Protective Agents Phase 2, Phase 3
47
protease inhibitors Phase 3
48 HIV Protease Inhibitors Phase 3
49 Antihypertensive Agents Phase 3
50 Angiotensin-Converting Enzyme Inhibitors Phase 3

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
2 Kronos Early Estrogen Prevention Study (KEEPS) Unknown status NCT00154180 Phase 4 Conjugated equine estrogens 0.45 mg/day;Transdermal estradiol, 50 mcg/day;Micronized progesterone, 200 mg/day x 12 d/month;CEE , progesterone, estradiol patch or placebo for each;CEE, progesterone, transdermal patch or the placebo
3 Lupus Atherosclerosis Prevention Study Completed NCT00120887 Phase 4 Atorvastatin
4 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
5 Effects of Lutein Supplementation on Subclinical Atherosclerosis Completed NCT01534533 Phase 2, Phase 3
6 The Study of Atherosclerosis With Ramipril and Rosiglitazone Completed NCT00140647 Phase 3 Ramipril;Rosiglitazone
7 The Fish and Fruit Study: Trial of Fish and Fruit to Improve Survival of Aboriginal People With End Stage Renal Disease Completed NCT00192543 Phase 3
8 Improving Stroke Rehabilitation: Spacing Effect and D-cycloserine Completed NCT00720759 Phase 2 D-cycloserine + distributed treatment;Placebo + distributed treatment
9 A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese Unknown status NCT01208116
10 Ultrasound Assessment of the Carotid Intimal Medial Thickness in Obese Subjects; Weight Loss Completed NCT02954627
11 Latinos Understanding the Need for Adherence Completed NCT02955238 Not Applicable
12 Sex Differences in Vascular Markers of Stroke Risk Completed NCT00681681
13 Progression of Sub-Clinical Atherosclerosis Completed NCT00241787
14 Effects of Growth Hormone Releasing Hormone in HIV Completed NCT01263717 Not Applicable tesamorelin;placebo
15 Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy Enrolling by invitation NCT02694094
16 Cardiovascular Risk Markers in Veterans With Post Traumatic Stress Disorder Terminated NCT01650220
17 Adult Growth Hormone Deficiency and Cardiovascular Risk Terminated NCT00720902 Not Applicable Growth hormone releasing hormone (GHRH) and arginine

Search NIH Clinical Center for Carotid Intimal Medial Thickness 2

Genetic Tests for Carotid Intimal Medial Thickness 2

Anatomical Context for Carotid Intimal Medial Thickness 2

MalaCards organs/tissues related to Carotid Intimal Medial Thickness 2:

42
Heart, Kidney, Endothelial

Publications for Carotid Intimal Medial Thickness 2

Articles related to Carotid Intimal Medial Thickness 2:

(show all 45)
# Title Authors Year
1
No Association of Genetic Markers with Carotid Intimal Medial Thickness in I^-Thalassemia Major Patients. ( 29441217 )
2018
2
Study of carotid intimal medial thickness in essential hypertension with or without left ventricular hypertrophy. ( 29063904 )
2017
3
Assessment of Increase in Aortic and Carotid Intimal Medial Thickness in Type 1 Diabetic Patients. ( 28028403 )
2016
4
Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes. ( 25968430 )
2015
5
Correlation of carotid intimal-medial thickness with estimated glomerular filtration rate and cardiovascular risk factors in chronic kidney disease. ( 24821154 )
2014
6
Correlation of serum phosphate with carotid intimal-medial thickness in chronic kidney disease patients. ( 24574625 )
2014
7
Carotid intimal-medial thickness in active professional American football players aged 23 to 35 years. ( 22196775 )
2012
8
Association of glycated hemoglobin with carotid intimal medial thickness in Asian Indians with normal glucose tolerance. ( 22795336 )
2012
9
Endothelial Function and Carotid Intimal Medial Thickness in Asymptomatic Subjects With and Without Cardiovascular Risk Factors. ( 28348684 )
2012
10
Carotid intimal-medial thickness is not increased in women with previous gestational diabetes mellitus. ( 22111041 )
2011
11
Effects of statins on progression of carotid atherosclerosis as measured by carotid intimal--medial thickness: a meta-analysis of randomized controlled trials. ( 20472815 )
2010
12
Adiponectin and carotid intimal medial thickness in subjects with and without glucose intolerance (CURES-82). ( 20105040 )
2010
13
Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathology. ( 19679833 )
2010
14
Absence of relation between depressive symptoms and carotid intimal medial thickness in the Baltimore Longitudinal Study of Aging. ( 18842746 )
2009
15
The relationship between race, cigarette smoking and carotid intimal medial thickness in systemic lupus erythematosus. ( 19861342 )
2009
16
Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular disease. ( 19644063 )
2009
17
Association of common carotid intimal medial thickness (CCA-IMT) with risk factors of atherosclerosis in patients with type 2 diabetes mellitus. ( 19750850 )
2009
18
Coronary calcification is more predictive of carotid intimal medial thickness in black compared to white middle aged men. ( 17350026 )
2008
19
[The relationship between the effect of amlodipine on carotid intimal-medial thickness and angiotensin converting enzyme genotypes in elderly hypertensive patients]. ( 19100063 )
2008
20
Association of high sensitivity C-reactive protein (hsCRP) and tumour necrosis factor-alpha (TNF-alpha) with carotid intimal medial thickness in subjects with different grades of glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURES-31). ( 18328265 )
2008
21
Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). ( 17531588 )
2007
22
Comparison of intensive and low-dose atorvastatin therapy in the reduction of carotid intimal-medial thickness in patients with coronary heart disease. ( 17344325 )
2007
23
Prediction of major adverse cardiovascular events by age-normalized carotid intimal medial thickness. ( 16233899 )
2006
24
Utility of carotid intimal medial thickness as a screening tool for evaluation of coronary artery disease in pre-transplant end stage renal disease. ( 17102544 )
2006
25
Insulin resistance/compensatory hyperinsulinemia predict carotid intimal medial thickness in patients with essential hypertension. ( 16399488 )
2006
26
Carotid intimal medial thickness in human immunodeficiency virus-infected women: effects of protease inhibitor use, cardiac risk factors, and the metabolic syndrome. ( 17003092 )
2006
27
Association between the ankle-brachial index and carotid intimal medial thickness in the Rancho Bernardo Study. ( 17027581 )
2006
28
Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study. ( 16430904 )
2006
29
Adolescent obesity is associated with high ambulatory blood pressure and increased carotid intimal-medial thickness. ( 16291358 )
2005
30
Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study. ( 14963283 )
2004
31
Cardiovascular risk assessment in individual patients from carotid intimal-medial thickness measurements. ( 15068748 )
2004
32
Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness. ( 15073382 )
2004
33
Usefulness of carotid intimal medial thickness and flow-mediated dilation in a preventive cardiovascular practice. ( 12804739 )
2003
34
Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus. ( 12598080 )
2003
35
C-reactive protein and carotid intimal medial thickness in a community population. ( 12006917 )
2002
36
Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: The Muscatine Study. ( 11733400 )
2001
37
Lack of association of insulin resistance and carotid intimal medial thickness in non-diabetic Asian Indian subjects. ( 11757080 )
2001
38
Role of carotid intimal-medial thickness in assessment of pre-clinical atherosclerosis. ( 11084778 )
2000
39
Increased carotid intimal-medial thickness and coronary calcification are related in young and middle-aged adults. The Muscatine study. ( 10458720 )
1999
40
Serum homocysteine, MTHFR gene polymorphism, and carotid intimal-medial thickness in NIDDM subjects. ( 10500310 )
1999
41
Endogenous androgens and carotid intimal-medial thickness in women. ( 10372702 )
1999
42
Carotid intimal-medial thickness and stiffness are not affected by hypercholesterolemia in uncomplicated essential hypertension. ( 10559027 )
1999
43
The effect of cholesterol reduction with fluvastatin on aortic compliance, coronary calcification and carotid intimal-medial thickness: a pilot study. ( 9816550 )
1998
44
Assessment of temporal bias in longitudinal measurements of carotid intimal-medial thickness in the Asymptomatic Carotid Artery Progression Study (ACAPS). ACAPS Research Group. ( 8795167 )
1996
45
Spatial distribution of carotid intimal-medial thickness as measured by B-mode ultrasonography. ( 8073462 )
1994

Variations for Carotid Intimal Medial Thickness 2

Expression for Carotid Intimal Medial Thickness 2

Search GEO for disease gene expression data for Carotid Intimal Medial Thickness 2.

Pathways for Carotid Intimal Medial Thickness 2

GO Terms for Carotid Intimal Medial Thickness 2

Sources for Carotid Intimal Medial Thickness 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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