CIMT2
MCID: CRT085
MIFTS: 25

Carotid Intimal Medial Thickness 2 (CIMT2)

Categories: Genetic diseases

Aliases & Classifications for Carotid Intimal Medial Thickness 2

MalaCards integrated aliases for Carotid Intimal Medial Thickness 2:

Name: Carotid Intimal Medial Thickness 2 57 72
Carotid Intimal Medial Thickness 57 13
Carotid Intimal Medial Thickness Quantitative Trait Locus on Chromosome 12 57
Cimt2 57

Classifications:



External Ids:

OMIM 57 608447
UMLS 72 C1838020

Summaries for Carotid Intimal Medial Thickness 2

MalaCards based summary : Carotid Intimal Medial Thickness 2, also known as carotid intimal medial thickness, is related to carotid intimal medial thickness 1 and glucose intolerance. An important gene associated with Carotid Intimal Medial Thickness 2 is CIMT (Carotid Intimal Medial Thickness). The drugs Simvastatin and HIV Protease Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney.

More information from OMIM: 608447

Related Diseases for Carotid Intimal Medial Thickness 2

Graphical network of the top 20 diseases related to Carotid Intimal Medial Thickness 2:



Diseases related to Carotid Intimal Medial Thickness 2

Symptoms & Phenotypes for Carotid Intimal Medial Thickness 2

Clinical features from OMIM:

608447

Drugs & Therapeutics for Carotid Intimal Medial Thickness 2

Drugs for Carotid Intimal Medial Thickness 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 3 79902-63-9 54454
2 HIV Protease Inhibitors Phase 3
3 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
4 Angiotensin-Converting Enzyme Inhibitors Phase 3
5 Lipid Regulating Agents Phase 3
6 Hypolipidemic Agents Phase 3
7
protease inhibitors Phase 3
8 Anticholesteremic Agents Phase 3
9 Antimetabolites Phase 3
10
Liraglutide Approved 204656-20-2 44147092
11
chloroquine Approved, Investigational, Vet_approved 54-05-7 2719
12 Incretins
13 Nutrients
14 Hypoglycemic Agents
15 Analgesics
16 Anti-Inflammatory Agents
17 Analgesics, Non-Narcotic
18 Antiparasitic Agents
19 Anti-Infective Agents
20 Chloroquine diphosphate 50-63-5
21 Peripheral Nervous System Agents
22 Anthelmintics
23 Antiprotozoal Agents
24 Anti-Inflammatory Agents, Non-Steroidal
25 Antimalarials
26 Antirheumatic Agents
27 Hormones
28 Hormone Antagonists
29 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
2 Stop Atherosclerosis in Native Diabetics Study (SANDS) Completed NCT00047424 Phase 3 simvastatin;ACE inhibitors
3 A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese Unknown status NCT01208116
4 Fat Redistribution and Metabolic Change in HIV Infection (FRAM) Unknown status NCT00331448
5 Epidemiology of Carotid Artery Atherosclerosis in Youth Completed NCT00005397
6 Ultrasound Assessment of the Carotid Intimal Medial Thickness in Obese Subjects Following a Significant Weight Loss Completed NCT02954627
7 Progression of Sub-Clinical Atherosclerosis Completed NCT00241787
8 Coronary Calcification Progression Study Completed NCT00006526
9 Molecular Epidemiology of Myocardial Infarction and Stroke in Older Adults - Ancillary to CHS Completed NCT00078429
10 CV Disease in Adolescents With Type 2 Diabetes Completed NCT00114998
11 Atherosclerosis, Plaque and CVD in Communities Completed NCT00091754
12 San Diego Partnership to Reduce Diabetes & Cardiovascular Disease in Latinos Completed NCT02955238
13 Genotoxic Stress, Atherosclerosis, and Metabolic Syndrome- Aim 3 Active, not recruiting NCT00455403 Chloroquine;Placebo Comparator
14 Assessment of Cardiovascular Risk Markers in GH Deficient Patients With Nonsecreting Pituitary Adenomas Terminated NCT00646308

Search NIH Clinical Center for Carotid Intimal Medial Thickness 2

Genetic Tests for Carotid Intimal Medial Thickness 2

Anatomical Context for Carotid Intimal Medial Thickness 2

MalaCards organs/tissues related to Carotid Intimal Medial Thickness 2:

41
Heart, Endothelial, Kidney, Pituitary, Liver, Bone, Breast

Publications for Carotid Intimal Medial Thickness 2

Articles related to Carotid Intimal Medial Thickness 2:

(show top 50) (show all 186)
# Title Authors PMID Year
1
Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12. 38 8
14730480 2004
2
Association of serum proprotein convertase subtilisin/kexin type 9 with early atherosclerosis in newly diagnosed type 2 diabetes mellitus. 38
31133497 2019
3
The effectiveness of high-resolution ultrasound in the assessment of the carotid intima-media thickness for postirradiated neck. 38
30683992 2019
4
Aortic, carotid intima-media thickness and flow- mediated dilation as markers of early atherosclerosis in a cohort of pediatric patients with rheumatic diseases. 38
29022136 2018
5
Target Organ Damage and Target Systolic Blood Pressure in Clinical Practice: The Campania Salute Network. 38
29566163 2018
6
Late-Life Depressive Symptoms as Partial Mediators in the Associations between Subclinical Cardiovascular Disease with Onset of Mild Cognitive Impairment and Dementia. 38
29254675 2018
7
No Association of Genetic Markers with Carotid Intimal Medial Thickness in β-Thalassemia Major Patients. 38
29441217 2018
8
Markers of subclinical atherosclerotic disease in HIV-infected individuals. 38
29568549 2018
9
Study of carotid intimal medial thickness in essential hypertension with or without left ventricular hypertrophy. 38
29063904 2017
10
Residual atherosclerotic cardiovascular disease risk in statin-treated adults: The Multi-Ethnic Study of Atherosclerosis. 38
28754224 2017
11
Carotid atherosclerosis promotes the progression of Alzheimer's disease: A three-year prospective study. 38
28810593 2017
12
Association between dairy intake, lipids and vascular structure and function in diabetes. 38
28572881 2017
13
Distributions of Subclinical Cardiovascular Disease in a Socioeconomically and Racially Diverse Sample. 38
28235961 2017
14
Chronic kidney disease - determinants of progression and cardiovascular risk. PROGREDIR cohort study: design and methods. 38
28443950 2017
15
Cardiovascular Health among Black and White Breast Cancer Patients Initiating Aromatase Inhibitor Therapy. 38
27779346 2017
16
Hepatic steatosis is associated with cardiometabolic risk in a rural Indian population: A prospective cohort study. 38
27723535 2016
17
Assessment of Increase in Aortic and Carotid Intimal Medial Thickness in Type 1 Diabetic Patients. 38
28028403 2016
18
Subclinical carotid atherosclerosis and neurocognitive function in an urban population. 38
27092741 2016
19
Development and Validation of Risk Prediction Models for Cardiovascular Events in Black Adults: The Jackson Heart Study Cohort. 38
27437649 2016
20
Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years. 38
26940919 2016
21
Nonalcoholic fatty liver disease and carotid artery atherosclerosis in children and adults: a meta-analysis. 38
26193052 2015
22
Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes. 38
25968430 2015
23
The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada. 38
26239008 2015
24
The expression of p66shc in peripheral blood monocytes is increased in patients with coronary heart disease and correlated with endothelium-dependent vasodilatation. 38
24676406 2015
25
Association between red blood cell distribution width (RDW) and carotid artery atherosclerosis (CAS) in patients with primary ischemic stroke. 38
25957866 2015
26
Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. 38
25271088 2015
27
Effects of age and smoking on endothelial function assessed by quantitative cardiovascular magnetic resonance in the peripheral and central vasculature. 38
25884943 2015
28
Meta-analysis of the effects of lifestyle modifications on coronary and carotid atherosclerotic burden. 38
25465939 2015
29
An evaluation of coronary atherosclerosis using coronary CT in subjects with asymptomatic carotid lesions. 38
25147763 2014
30
Is There Any Relationship between Joint Destruction and Carotid Intima-media Thickness in Patients with Rheumatoid Arthritis? 38
25140104 2014
31
Correlation of carotid intimal-medial thickness with estimated glomerular filtration rate and cardiovascular risk factors in chronic kidney disease. 38
24821154 2014
32
Potential anti-atherosclerotic effects of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus. 38
24390468 2014
33
Comparison of carotid intima-media thickness in pediatric patients with metabolic syndrome, heterozygous familial hyperlipidemia and normals. 38
24955251 2014
34
Correlation of serum phosphate with carotid intimal-medial thickness in chronic kidney disease patients. 38
24574625 2014
35
Effects of GH on body composition and cardiovascular risk markers in young men with abdominal obesity. 38
23824419 2013
36
The relationship between pediatric nonalcoholic fatty liver disease and cardiovascular risk factors and increased risk of atherosclerosis in obese children. 38
22875138 2013
37
Low Bone Mass is Associated with Increased Carotid Intima Media Thickness in Men with Type 2 Diabetes Mellitus. 38
23861625 2013
38
Bone Mineral Density as a Predictor of Atherosclerosis and Arterial Wall Stiffness in Obese African-American Women. 38
23381741 2012
39
Carotid atherosclerosis and prospective risk of dementia. 38
23103489 2012
40
Association of glycated hemoglobin with carotid intimal medial thickness in Asian Indians with normal glucose tolerance. 38
22795336 2012
41
Endothelial Function and Carotid Intimal Medial Thickness in Asymptomatic Subjects With and Without Cardiovascular Risk Factors. 38
28348684 2012
42
Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: the multi-ethnic study of atherosclerosis. 38
22628436 2012
43
Quantification of atherosclerotic plaque activity and vascular inflammation using [18-F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). 38
22588186 2012
44
Carotid intimal-medial thickness in active professional American football players aged 23 to 35 years. 38
22196775 2012
45
Body composition, C-reactive protein, carotid artery remodeling and subclinical atherosclerosis in a general Taiwanese population. 38
22205174 2012
46
Impact of subclinical atherosclerosis on cardiovascular disease events in individuals with metabolic syndrome and diabetes: the multi-ethnic study of atherosclerosis. 38
21844289 2011
47
Carotid intimal-medial thickness is not increased in women with previous gestational diabetes mellitus. 38
22111041 2011
48
Oxidative stress, endothelial function, carotid artery intimal thickness and their correlates among chronic peritoneal dialysis patients. 38
22022087 2011
49
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. 38
21778438 2011
50
Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosis. 38
21505504 2011

Variations for Carotid Intimal Medial Thickness 2

Expression for Carotid Intimal Medial Thickness 2

Search GEO for disease gene expression data for Carotid Intimal Medial Thickness 2.

Pathways for Carotid Intimal Medial Thickness 2

GO Terms for Carotid Intimal Medial Thickness 2

Sources for Carotid Intimal Medial Thickness 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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