MCID: CRT013
MIFTS: 51

Carotid Stenosis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Stenosis

MalaCards integrated aliases for Carotid Stenosis:

Name: Carotid Stenosis 12 54 44 15 70
Carotid Artery Stenosis 12 6 15
Stenosis, Carotid Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13001
MeSH 44 D016893
NCIt 50 C95804
SNOMED-CT 67 195181000
UMLS 70 C0007282

Summaries for Carotid Stenosis

MalaCards based summary : Carotid Stenosis, also known as carotid artery stenosis, is related to amaurosis fugax and carotid artery disease. An important gene associated with Carotid Stenosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Midazolam and Desflurane have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 73 Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually... more...

Related Diseases for Carotid Stenosis

Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 595)
# Related Disease Score Top Affiliating Genes
1 amaurosis fugax 31.5 MTHFR MMP9
2 carotid artery disease 30.7 SELP SELE REN MMP9 MMP1 CRP
3 lipid metabolism disorder 30.7 SELE CRP APOE ACE
4 branch retinal artery occlusion 30.6 VEGFA MTHFR CRP
5 mild cognitive impairment 30.6 MTHFR APOE ACE
6 facial paralysis 30.6 TNF CRP ACE
7 active peptic ulcer disease 30.6 VWF F7 CRP
8 coronary heart disease 1 30.6 F7 CRP APOE ACE
9 aortic dissection 30.5 SPP1 MMP9 CRP ACE
10 chlamydia pneumonia 30.4 TNF CRP APOE
11 retinal artery occlusion 30.4 VEGFA MTHFR CRP ACE
12 intracranial aneurysm 30.4 TNF CDKN2B-AS1 APOE ACE
13 silent myocardial infarction 30.4 CRP ACE
14 intracranial embolism 30.4 VWF SELP CRP ACE
15 intracranial thrombosis 30.4 VWF SELP MTHFR
16 ischemia 30.4 VEGFA SELP SELE ICAM1 ACE
17 central sleep apnea 30.3 REN CRP ACE
18 arteriosclerosis obliterans 30.3 VCAM1 SELP ICAM1
19 homocysteinemia 30.3 VWF VCAM1 MTHFR CRP APOE
20 angina pectoris 30.2 ICAM1 CRP ACE
21 coronary stenosis 30.2 VWF ICAM1 CRP APOE ACE
22 tolosa-hunt syndrome 30.2 CRP ACE
23 aortic valve disease 2 30.2 VWF SPP1 REN CRP ACE
24 cholesterol embolism 30.2 REN F7 CRP ACE
25 atrial fibrillation 30.2 VWF SELP CRP ACE
26 cholesteatoma of middle ear 30.2 MMP9 MMP1 ICAM1
27 mitral valve disease 30.2 REN MMP1 CRP ACE
28 hepatic encephalopathy 30.2 TNF S100B MMP9
29 intermediate coronary syndrome 30.1 VWF VCAM1 SELP REN CRP ACE
30 systolic heart failure 30.1 TNF MMP9 CRP ACE
31 thrombophilia due to thrombin defect 30.1 VWF MTHFR HABP2
32 retinal vein occlusion 30.1 VEGFA TNF MTHFR ACE
33 retinal vascular disease 30.1 VEGFA TNF REN MTHFR ICAM1 ACE
34 nonarteritic anterior ischemic optic neuropathy 30.1 VEGFA MTHFR CRP ACE
35 peripheral vascular disease 30.1 VWF VEGFA VCAM1 SELP SELE MTHFR
36 cerebral atherosclerosis 30.1 MTHFR CRP APOE ACE
37 central retinal artery occlusion 30.0 VEGFA MTHFR CRP
38 sickle cell disease 30.0 VWF VCAM1 SELP SELE
39 neuroretinitis 30.0 CRP ACE
40 generalized atherosclerosis 30.0 VWF REN CRP APOE ACE
41 aortic valve disease 1 30.0 VWF SPP1 REN MMP9 ACE
42 mitral valve stenosis 30.0 VWF SELP REN CRP ACE
43 aortic disease 30.0 REN MMP9 CRP ACE
44 central retinal vein occlusion 30.0 VWF VEGFA MTHFR
45 moyamoya disease 1 29.9 VWF VEGFA MTHFR MMP9 CRP
46 microvascular complications of diabetes 5 29.9 VEGFA VCAM1 ICAM1 ACE
47 arteries, anomalies of 29.9 VEGFA VCAM1 TNF REN ICAM1 CRP
48 heart valve disease 29.9 VWF REN CRP ACE
49 retinal vascular occlusion 29.9 VEGFA SELP MTHFR ICAM1 CRP
50 brain edema 29.9 VEGFA MMP9 CRP

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to Carotid Stenosis

Symptoms & Phenotypes for Carotid Stenosis

MGI Mouse Phenotypes related to Carotid Stenosis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ACE APOE CRP F7 HABP2 ICAM1
2 cardiovascular system MP:0005385 10.34 ACE APOE CRP F7 ICAM1 MMP9
3 growth/size/body region MP:0005378 10.32 ACE APOE F7 ICAM1 MMP9 MTHFR
4 immune system MP:0005387 10.28 ACE APOE CRP HABP2 ICAM1 MMP1
5 hematopoietic system MP:0005397 10.23 ACE APOE ICAM1 MMP9 REN SELE
6 mortality/aging MP:0010768 10.13 ACE APOE F7 HABP2 ICAM1 MMP9
7 integument MP:0010771 10.07 APOE ICAM1 MMP9 MTHFR S100B SELE
8 liver/biliary system MP:0005370 10.02 ACE APOE HABP2 MTHFR SELE SELP
9 neoplasm MP:0002006 9.7 ACE ICAM1 MMP1 MMP9 SPP1 TNF
10 no phenotypic analysis MP:0003012 9.5 APOE F7 MTHFR TNF VCAM1 VEGFA
11 vision/eye MP:0005391 9.32 ACE APOE ICAM1 MMP9 MTHFR SELE

Drugs & Therapeutics for Carotid Stenosis

Drugs for Carotid Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 160)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Desflurane Approved Phase 4 57041-67-5 42113
3
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
4
Acetaminophen Approved Phase 4 103-90-2 1983
5
Evolocumab Approved Phase 4 1256937-27-5
6
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
7
Atorvastatin Approved Phase 4 134523-00-5 60823
8
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
9
Remifentanil Approved Phase 4 132875-61-7 60815
10
tannic acid Approved Phase 4 1401-55-4
11
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
12
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
13
Amlodipine Approved Phase 4 88150-42-9 2162
14
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
15
Losartan Approved Phase 4 114798-26-4 3961
16
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
17 insulin Phase 4
18 Insulin, Globin Zinc Phase 4
19 Antioxidants Phase 4
20 Purinergic P2Y Receptor Antagonists Phase 4
21 Anesthetics, General Phase 4
22 Anesthetics, Intravenous Phase 4
23 Anesthetics, Inhalation Phase 4
24 Vasodilator Agents Phase 4
25 Analgesics, Non-Narcotic Phase 4
26 Fibrinolytic Agents Phase 4
27 Analgesics Phase 4
28 Antirheumatic Agents Phase 4
29 Cyclooxygenase Inhibitors Phase 4
30 Anti-Inflammatory Agents Phase 4
31 Antipyretics Phase 4
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4
33 Neurotransmitter Agents Phase 4
34 Anticholesteremic Agents Phase 4
35 Antimetabolites Phase 4
36 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
37 Lipid Regulating Agents Phase 4
38 Calcium, Dietary Phase 4
39 Hypolipidemic Agents Phase 4
40 Adrenergic Agents Phase 4
41 Adrenergic alpha-Agonists Phase 4
42 Adrenergic Agonists Phase 4
43 Narcotics Phase 4
44 Hypnotics and Sedatives Phase 4
45 Analgesics, Opioid Phase 4
46 Fluorodeoxyglucose F18 Phase 4
47 Anti-Arrhythmia Agents Phase 4
48 Antihypertensive Agents Phase 4
49 Giapreza Phase 4
50 Angiotensinogen Phase 4

Interventional clinical trials:

(show top 50) (show all 235)
# Name Status NCT ID Phase Drugs
1 The Problem of Insulin Resistance in Patients After Carotid Revascularization Unknown status NCT03419767 Phase 4 Melatonin
2 Comparison of Staged Angioplasty v.s. Routine Single-stage Stenting (CAS) in the Treatment of Patients With Carotid Artery Stenosis at High Risk of Hyperperfusion (STEP): A Randomized Controlled Trial Unknown status NCT02224209 Phase 4
3 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
4 Efficacy of Two Different Pre-Intervention Therapeutic Strategies With Clopidogrel and Atorvastatin for the Prevention of Cerebral Damage During Carotid Artery Stenting. Armyda-Caro Randomized Trial. Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
5 A Randomized Evaluation of Short Term and Long Term Outcome After Endovascular Repair by Stenting of Carotid Artery Stenosis in Patients With Severe (70% and Higher) Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
6 The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
7 Time to Post-Anesthesia Neurological Evaluation and Hemodynamic Stability in Carotid Endarterectomy Comparing Three General Anesthetic Techniques Targeted to a Preset Bispectral Index Value: a Pilot Study Completed NCT03996148 Phase 4 Remifentanil, Propofol, and Desflurane;Remifentanil, Dexmedetomidine, and Desflurane;Remifentanil and Desflurane
8 Co-administration of Dexmedetomidine in Carotid Endarterectomy (CEA) With Intraoperative SSEP and MEP Monitoring: A Single-centre Prospective Randomized Controlled Trial Completed NCT04662177 Phase 4 Dexmedetomidine
9 Does the Magnitude of Platelet Inhibition Inversely Correlate With the Number of TCD-detected Microemboli in Asymptomatic Patients Undergoing Carotid Artery Stenting Prior to Cardiac Surgery Who Are Being Pre-treated With 300 mg or 600 mg Loading Dose of Clopidogrel? Completed NCT01146301 Phase 4 Clopidogrel
10 Comparison the Effect on Cerebral Oxygenation by Sevoflurane-remifentanil or Propofol-remifentanil Anesthesia Using Near-infrared Spectroscopy in Patients Undergoing Carotid Endarterectomy) Completed NCT02609087 Phase 4 Sevoflurane;Propofol
11 Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWire™ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System Completed NCT00287508 Phase 4
12 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
13 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
14 Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis Recruiting NCT03931161 Phase 4 Evolocumab Auto-Injector [Repatha];Placebo Auto-Injector
15 Efficacy of Two Different Doses of Atorvastatin for Prevention of Periprocedural Ischemic Brain Damage in Chinese Patients Undergoing Carotid Artery Stenting (CAS) Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
16 Study of Lipids Inside the Carotid With Evolocumab: A Randomized Trial of Evolocumab on Carotid Artery Atherosclerotic Plaque Morphology Prior to Carotid EndArterectomy (SLICE-CEA CardioLink-8 Study) Recruiting NCT04539223 Phase 4 Evolocumab
17 Phase 4: The Effects of Dexmedetomidine and Remifentanil on Postoperative Hemodynamics and Pain/Opioids in Patients Undergoing Carotid Endarterectomy Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
18 Carotid Endarterectomy Versus Optimal Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
19 The NexStent® Carotid Stent System: A Post Market Approval Evaluation Study In Conjunction With the FilterWire EZ™ Embolic Protection System Terminated NCT00478673 Phase 4
20 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
21 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting (PROVENON Study) A Randomized Prospective MRI-based Trial. Unknown status NCT01331473 Phase 3
22 Ticlopidine+Ginkgo Biloba Versus Clopidogrel in Clopidogrel Resistant Patients Undergoing Cartoid Artery Stent Placement Unknown status NCT02133989 Phase 3 Ticlopidine + Ginko biloba;Clopidogrel
23 The Embolic Protection With Reverse Flow Study of the GORE Neuro Protection System in Carotid Stenting of Subjects At High Risk for Carotid Endarterectomy Completed NCT00594100 Phase 3
24 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (GORE EMBOLDEN) Completed NCT00766493 Phase 3
25 Treatment of Carotid Stenosis With Carotid Stenting and Neurologic Protection With Pre-Procedure and Follow-Up With MRI DIffusion Imaging and Neuropsychological Testing Completed NCT00318851 Phase 3
26 Randomized, Double-Blind, Multicenter, Trial to Assess the Effect of High & Low Doses of ZD4522 on Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects With Asymptomatic Carotid Stenosis After 24 Months of Dosing. Completed NCT00654394 Phase 3 Rosuvastatin
27 The ViVEXX Carotid Revascularization Trial (VIVA) for High Surgical Risk Patients With Extracranial Carotid Artery Stenosis Using the Bard ViVEXX Carotid Stent and Emboshield BareWire Rapid Exchange Embolic Protection System Completed NCT00417963 Phase 3
28 Risk Reduction of Symptomatic and Silent Brain Infarctions During Carotid Endarterectomy and Carotid Stenting Due to Ultrasound Activation of Endogenous Fibrinolytic System Using Transcranial Doppler Monitoring Completed NCT01591005 Phase 3
29 Prospective, Non-Randomized, Multi-Center, Single-Arm Trial to Assess Safety & Efficacy of the Acculink Carotid Stent System With the Accunet Embolic Protection System in High-Risk Patients With Carotid Artery Lesions. Completed NCT00180518 Phase 2, Phase 3
30 Randomized Controlled Trial Analyzing the Role of Systematic Preoperative Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3
31 Multicenter, Open-label Study to Evaluate the Safety and Efficacy (by Blinded Reading) of Contrast-Enhanced Magnetic Resonance Angiography (MRA) After a Single Intravenous Injection of 0.1 mmol/kg Gadobutrol in Subjects With Known or Suspected Vascular Disease of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
32 Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
33 Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
34 Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes Recruiting NCT02850081 Phase 3 Statin;Atorvastatin
35 Protection During Carotid Stenting in High Risk Patients With the TriActiv ProGuard System Terminated NCT00395785 Phase 2, Phase 3
36 Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy. Terminated NCT01415648 Phase 3
37 Abciximab Versus Aspirin for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic >50% Carotid Stenosis: A Pilot Study (ASTERICS) Terminated NCT00126139 Phase 3 Abciximab
38 Randomized, Multicenter, Double-blind, Placebo-controlled, Two-arm Parallel Group Trial of Rimonabant 20-mg od, for Inhibition of Atherosclerosis Progression Assessed by Carotid Artery Intima-media Thickness (CIMT), in Overweight Patients With Additional Risk Factors Terminated NCT00228176 Phase 3 Rimonabant;Placebo (for Rimonabant)
39 The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Asymptomatic and Symptomatic Carotid Artery Stenosis - an Open Proof of Concept Study. Unknown status NCT00904254 Phase 2
40 A Pilot Study Assessing the Safety and Efficacy of Low Dosage of Terazosin in Subjects Undergoing Carotid Artery Stenting Unknown status NCT03195673 Phase 2 Terazosin
41 Phase 2 Study Randomized Placebo Controlled With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis Unknown status NCT01923012 Phase 2 Vitamin K2 (Menaquinone)
42 Randomized Controlled Clinical Study on Vulnerable Plaque of Carotid Artery With Chinese Herbal and Insects Medicine Unknown status NCT03072225 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
43 Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting Completed NCT01654666 Phase 2
44 Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Phase II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo Controlled Superiority Study With Parallel Groups Completed NCT01645306 Phase 2 Revacept;Placebo
45 A Phase 2 Randomized, Double-blind, Placebo-controlled Study of the Effects of VIA-2291, a 5-Lipoxygenase Inhibitor, on Atherosclerotic Plaque and Biomarkers of Vascular Inflammation in Patients With Carotid Stenosis Undergoing Elective Carotid Endarterectomy Completed NCT00352417 Phase 2 VIA-2291;Placebo
46 Recurrent Carotid Stenosis Completed NCT00000527 Phase 2 aspirin;dipyridamole
47 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
48 Assessment of Unstable Carotid Plaque Using PET and MR Imaging in Patient Referred to Endarterectomy: The CAROTEP Study Recruiting NCT03353103 Phase 2 Sodium fluoride F-18 PET imaging
49 Prevention of Cerebral Ischaemia in Stent Treatment for Carotid Artery Stenosis - A Randomised Multi-centre Phase II Trial Comparing Ticagrelor Versus Clopidogrel With Outcome Assessment on MRI (PRECISE-MRI) Recruiting NCT02677545 Phase 2 Ticagrelor;Clopidogrel;Aspirin
50 Amyloid Deposition and Preexisting Vulnerable Carotid Plaque Features Predicting Cognitive Improvement After Surgery Recruiting NCT03068442 Phase 2 Imaging with flutemetamol F 18 PET/CT

Search NIH Clinical Center for Carotid Stenosis

Cochrane evidence based reviews: carotid stenosis

Genetic Tests for Carotid Stenosis

Anatomical Context for Carotid Stenosis

MalaCards organs/tissues related to Carotid Stenosis:

40
Brain, Heart, Endothelial, Bone, Kidney, Smooth Muscle, Neutrophil

Publications for Carotid Stenosis

Articles related to Carotid Stenosis:

(show top 50) (show all 9780)
# Title Authors PMID Year
1
Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. 54 61
19221176 2009
2
Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study. 61 54
18984437 2008
3
Markers of instability in high-risk carotid plaques are reduced by statins. 61 54
18295103 2008
4
Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP. 54 61
18605956 2008
5
High serum level of matrix metalloproteinase-1 and its rapid surge after intervention in patients with significant carotid atherosclerosis. 61 54
18218585 2008
6
Metalloproteinase expression in carotid plaque and its correlation with plasma levels before and after carotid endarterectomy. 61 54
18166633 2007
7
Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis. 61 54
17194891 2007
8
Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1. 61 54
17268019 2007
9
Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis. 61 54
17030690 2006
10
Polymorphisms in the PON gene cluster are associated with Alzheimer disease. 54 61
16319130 2006
11
Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis. 54 61
16107361 2005
12
Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism. 54 61
15486068 2005
13
Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis. 61 54
15337875 2004
14
Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells. 54 61
14977886 2004
15
Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis. 61 54
12578864 2003
16
Serial measurement of surface expressions of CD63, P-selectin and CD40 ligand on platelets in atherosclerotic ischemic stroke. A possible role of CD40 ligand on platelets in atherosclerotic ischemic stroke. 61 54
13130179 2003
17
Thrombocyte activation increases with the degree of carotid artery stenosis. 61 54
17903894 2002
18
Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. 54 61
12364729 2002
19
Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease. 61 54
11388660 2001
20
Dysregulation of lncRNA SNHG1/miR-145 axis affects the biological function of human carotid artery smooth muscle cells as a mechanism of carotid artery restenosis. 61
33777187 2021
21
Diagnostic Yield of Neck CT Angiography in Young Adults With Anterior Circulation Ischemic Stroke: A Community Based Study. 61
33791054 2021
22
Effects of Neck Radiation on Result of Doppler Sonography of Carotid Arteries in Head and Neck Cancer Patients. 61
33461025 2021
23
Patients with atherosclerotic peripheral arterial disease have a high risk of lung cancer: Systematic review and meta-analysis of literature. 61
33752847 2021
24
Evaluation of the interrater and intermethod agreement of the German multiparametric ultrasound criteria for the grading of internal carotid artery stenosis. 61
32945912 2021
25
Evaluation of the discussion of late effects and screening recommendations in survivors of adolescent and young adult (AYA) lymphoma. 61
32767044 2021
26
Carotid Revascularization Improves Cognition in Patients With Asymptomatic Carotid Artery Stenosis and Cognitive Decline. Greater Improvement in Younger Patients With More Disordered Neuropsychological Performance. 61
33461024 2021
27
[Asymptomatic carotid stenosis: What is new?] 61
33780986 2021
28
Procedural benefit for asymptomatic carotid stenosis is wishful thinking. 61
33766250 2021
29
A balanced approach is warranted for patients with asymptomatic carotid stenosis. 61
33766251 2021
30
[Webinar for S3 guideline "diagnosis, treatment, and aftercare of extracranial carotid stenosis"]. 61
33792754 2021
31
Effectiveness and safety of dual-layer stents in carotid artery disease: a systematic review. 61
33337115 2021
32
Peripheral Vascular Resistance in Cerebral Arteries in Patients With Carotid Atherosclerosis - Substudy Results of the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients With the Carotid Bifurcation Plaque Study (ANTIQUE). 61
33792942 2021
33
Relationship between the abdominal aortic diameter and carotid atherosclerosis in middle-aged patients without established atherosclerotic cardiovascular diseases. 61
33463974 2021
34
Carotid webs management in symptomatic patients. 61
32889072 2021
35
Significance of concurrent ipsilateral intracranial carotid artery stenosis in carotid revascularization. 61
33647731 2021
36
Factors associated with hemodynamic instability following carotid artery stenting. 61
33706060 2021
37
Ficolin-2 serum levels predict the occurrence of acute coronary syndrome in patients with severe carotid artery stenosis. 61
33513354 2021
38
Carotid Endarterectomy and Stenting in a Chinese Population: Safety Outcome of the Revascularization of Extracranial Carotid Artery Stenosis Trial. 61
32686047 2021
39
A Less Frequent Etiology of Limb Shaking Syndrome: A Severe Middle Cerebral Artery Stenosis. 61
33497937 2021
40
Carotid Endarterectomy is often not Possible after an Unheralded Stroke: Unheralded Stroke in Carotid Artery Stenosis. 61
33429239 2021
41
Predictors of Carotid Artery Stenting-Induced Hemodynamic Instability. 61
33779409 2021
42
Investigation of macular and optic nerve head structural changes using spectral domain optical coherence tomography in internal carotid artery stenosis. 61
33170420 2021
43
Case Report: Combined Ischemic Optic Neuropathy and Central Retinal Artery Occlusion after Starting Hemodialysis. 61
33633019 2021
44
Carotid stenosis, stroke, and carotid artery revascularization. 61
33744381 2021
45
Hemorrhagic Plaques in Mild Carotid Stenosis: The Risk of Stroke. 61
32799939 2021
46
Bilateral Cerebral Hyperperfusion Syndrome Following Carotid Artery Stenting in Stroke - A Case Report. 61
33333479 2021
47
Association between estimated glomerular filtration rate and clinical outcomes in ischemic stroke patients with high-grade carotid artery stenosis. 61
33740899 2021
48
Association of Carotid Artery Endothelial Signal Intensity Gradient with Unilateral Large Artery Ischemic Stroke. 61
33756458 2021
49
Predictive Model of Early Neurological Deterioration in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study. 61
33387889 2021
50
Carotid endarterectomy with concomitant distal endovascular intervention is associated with increased rates of stroke and death. 61
32707384 2021

Variations for Carotid Stenosis

ClinVar genetic disease variations for Carotid Stenosis:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 RNF213-AS1 , RNF213 NM_001256071.3(RNF213):c.11659A>G (p.Lys3887Glu) SNV Uncertain significance 523426 rs1555673862 GRCh37: 17:78337499-78337499
GRCh38: 17:80363699-80363699

Expression for Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for Carotid Stenosis

Pathways related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 VWF VEGFA VCAM1 TNF MMP9 MMP1
2
Show member pathways
13.05 VCAM1 TNF SPP1 SELP SELE MMP9
3
Show member pathways
12.67 VCAM1 SPP1 MMP9 MMP1 ICAM1
4
Show member pathways
12.32 VEGFA VCAM1 SELE ICAM1
5
Show member pathways
12.13 TNF MTHFR ICAM1 F7 CRP APOE
6 12.11 VEGFA TNF MMP9 MMP1
7
Show member pathways
12.06 VWF VCAM1 SPP1 ICAM1
8 12.03 VCAM1 SELP SELE ICAM1
9 11.9 TNF SELP MMP9 ICAM1
10 11.9 VCAM1 TNF SELE MMP9 ICAM1
11 11.88 VEGFA VCAM1 TNF SELE MMP9 ICAM1
12 11.78 VEGFA TNF MMP1 ICAM1
13 11.77 VEGFA VCAM1 TNF SELE ICAM1
14 11.73 SELE MMP1 ICAM1
15 11.66 VEGFA MMP9 MMP1
16 11.61 VCAM1 TNF ICAM1
17 11.59 VEGFA SPP1 MMP9
18 11.57 TNF SPP1 MMP9
19 11.49 VEGFA VCAM1 TNF MMP9 MMP1 ICAM1
20 11.46 TNF SELP MMP9 ICAM1
21 11.41 TNF SPP1 APOE
22 11.41 VCAM1 SELE ICAM1
23 11.31 SELE MMP9 MMP1
24 11.3 VCAM1 TNF SELE ICAM1
25 11.25 VCAM1 TNF SELP SELE ICAM1
26 11.22 MMP9 APOE ACE
27
Show member pathways
10.97 VEGFA VCAM1 TNF SELE MMP9 MMP1
28 10.87 VCAM1 TNF ICAM1

GO Terms for Carotid Stenosis

Cellular components related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 VWF VEGFA TNF SPP1 SERPINA12 S100B
2 external side of plasma membrane GO:0009897 9.72 VCAM1 TNF SELP ICAM1 ACE
3 collagen-containing extracellular matrix GO:0062023 9.65 VWF MMP9 ICAM1 F7 APOE
4 extracellular matrix GO:0031012 9.55 VWF VEGFA MMP9 MMP1 APOE
5 extracellular space GO:0005615 9.55 VWF VEGFA VCAM1 TNF SPP1 SERPINA12

Biological processes related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10 VWF VCAM1 SPP1 SELP SELE ICAM1
2 proteolysis GO:0006508 9.99 REN MMP9 MMP1 HABP2 F7 ACE
3 inflammatory response GO:0006954 9.96 TNF SPP1 SELP SELE CRP
4 negative regulation of gene expression GO:0010629 9.89 VEGFA TNF CDKN2B-AS1 APOE ACE
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 VEGFA TNF ICAM1 APOE
6 cytokine-mediated signaling pathway GO:0019221 9.85 VEGFA VCAM1 TNF MMP9 MMP1 ICAM1
7 response to hypoxia GO:0001666 9.83 VEGFA VCAM1 MTHFR ICAM1 F7
8 response to lipopolysaccharide GO:0032496 9.8 VCAM1 SELP SELE REN ICAM1
9 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.78 VEGFA TNF SERPINA12 SELP
10 positive regulation of protein complex assembly GO:0031334 9.72 VEGFA TNF MMP1
11 leukocyte migration GO:0050900 9.63 TNF SELP SELE MMP9 MMP1 ICAM1
12 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.62 VCAM1 SELP SELE ICAM1
13 cellular response to UV-A GO:0071492 9.59 MMP9 MMP1
14 negative regulation of lipid storage GO:0010888 9.58 TNF CRP
15 positive regulation of leukocyte tethering or rolling GO:1903238 9.57 SELP SELE
16 leukocyte cell-cell adhesion GO:0007159 9.56 VCAM1 SELP SELE ICAM1
17 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.54 VEGFA ACE
18 membrane to membrane docking GO:0022614 9.52 VCAM1 ICAM1
19 leukocyte tethering or rolling GO:0050901 9.26 VCAM1 TNF SELP SELE
20 extracellular matrix organization GO:0030198 9.17 VWF VCAM1 TNF SPP1 MMP9 MMP1

Molecular functions related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 MMP9 MMP1 HABP2 F7
2 integrin binding GO:0005178 9.46 VWF VCAM1 SPP1 ICAM1
3 peptidase activity GO:0008233 9.43 REN MMP9 MMP1 HABP2 F7 ACE
4 endopeptidase activity GO:0004175 9.02 REN MMP9 MMP1 F7 ACE

Sources for Carotid Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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