MCID: CRT013
MIFTS: 53

Carotid Stenosis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Stenosis

MalaCards integrated aliases for Carotid Stenosis:

Name: Carotid Stenosis 12 55 44 15 73
Carotid Artery Stenosis 12 6 15
Carotid Stenosis, Susceptibility to 13
Stenosis, Carotid Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13001
MeSH 44 D016893
NCIt 50 C95804
SNOMED-CT 68 64586002
UMLS 73 C0007282

Summaries for Carotid Stenosis

MalaCards based summary : Carotid Stenosis, also known as carotid artery stenosis, is related to coronary artery anomaly and amaurosis fugax. An important gene associated with Carotid Stenosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Spinal Cord Injury and Interleukin-4 and 13 signaling. The drugs Clopidogrel and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually... more...

Related Diseases for Carotid Stenosis

Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 30.2 ACE CRP F7 SELP
2 amaurosis fugax 30.1 MMP9 MTHFR
3 peripheral vascular disease 30.0 ACE CRP SELP
4 arteries, anomalies of 29.9 ACE APOE CRP MMP9 SELP TNF
5 carotid artery disease 29.8 ACE APOE CRP MMP1 MMP9
6 vascular dementia 29.7 ACE APOE MTHFR TNF
7 intermittent claudication 29.7 ACE CRP SELP
8 takayasu arteritis 29.6 CRP MMP9 TNF
9 kawasaki disease 29.6 CRP MMP9 TNF
10 kidney disease 29.6 ACE APOE CRP SPP1 TNFRSF11B
11 aortic aneurysm, familial abdominal, 1 29.5 ACE APOE CDKN2B-AS1 CRP MMP1 MMP9
12 chronic kidney failure 29.5 ACE CRP MTHFR SPP1 TNFRSF11B
13 sleep apnea 29.5 ACE APOE CRP S100B TNF
14 arteriosclerosis 29.3 ACE APOE CRP MMP9 SELP SPP1
15 peripheral artery disease 29.3 ACE CDKN2B-AS1 CRP SELP TNFRSF11B
16 vascular disease 29.1 ACE APOE CRP MMP9 MTHFR SELP
17 stroke, ischemic 29.1 ACE APOE CDKN2B-AS1 CRP F7 MTHFR
18 heart disease 28.9 ACE APOE CRP F7 MTHFR S100B
19 ischemic heart disease 28.9 ACE APOE CRP F7 MTHFR TNF
20 cerebrovascular disease 28.9 ACE APOE CRP F7 MMP9 MTHFR
21 moyamoya disease 2 11.4
22 moyamoya disease 5 11.3
23 moyamoya disease 6 with or without achalasia 11.3
24 ischemia 10.3
25 spastic entropion 10.3 MMP1 MMP9
26 chronic actinic dermatitis 10.3 MMP1 MMP9
27 lentigo maligna melanoma 10.2 MMP9 S100B
28 periodontitis, chronic 10.2 MMP1 TNFRSF11B
29 internal hemorrhoid 10.2 MMP1 MMP9
30 chronic meningitis 10.2 CRP MMP9
31 chronic venous insufficiency 10.2 MMP1 MMP9 SELP
32 osteoporotic fracture 10.2 MTHFR TNFRSF11B
33 transient cerebral ischemia 10.2
34 chromoblastomycosis 10.2 MMP1 MMP9
35 moderate and severe traumatic brain injury 10.2 ACE APOE
36 head injury 10.2 APOE S100B
37 aortic disease 10.2 APOE CRP MMP9
38 light chain deposition disease 10.2 MMP1 MMP9
39 odontogenic myxoma 10.2 MMP1 MMP9 S100B
40 preterm premature rupture of the membranes 10.2 CRP MMP1 MMP9
41 uremia 10.2 CRP SPP1 TNFRSF11B
42 mastoiditis 10.2 CRP MTHFR
43 mesenteric vascular occlusion 10.2 F7 MTHFR
44 autoimmune inner ear disease 10.2 MMP9 TNF
45 pyosalpinx 10.1 APOE CRP
46 aortic aneurysm 10.1
47 ischemic neuropathy 10.1 CRP MTHFR
48 varicose veins 10.1 MMP1 MMP9 MTHFR
49 autoimmune myocarditis 10.1 SPP1 TNF
50 drug reaction with eosinophilia and systemic symptoms 10.1 CRP TNF

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to Carotid Stenosis

Symptoms & Phenotypes for Carotid Stenosis

MGI Mouse Phenotypes related to Carotid Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ACE APOE CRP F7 HABP2 MMP1
2 cardiovascular system MP:0005385 10.18 ACE APOE CRP F7 MMP9 SELP
3 immune system MP:0005387 10.18 ACE APOE CRP HABP2 MMP1 MMP9
4 growth/size/body region MP:0005378 10.16 ACE APOE F7 MMP9 MTHFR SELP
5 integument MP:0010771 9.97 APOE MMP9 MTHFR S100B SELP SPP1
6 mortality/aging MP:0010768 9.9 ACE APOE F7 HABP2 MMP9 MTHFR
7 limbs/digits/tail MP:0005371 9.8 APOE MMP9 MTHFR TFPI TNF TNFRSF11B
8 liver/biliary system MP:0005370 9.8 ACE APOE HABP2 MTHFR SELP SPP1
9 neoplasm MP:0002006 9.43 ACE MMP1 MMP9 SPP1 TNF TREM1
10 skeleton MP:0005390 9.32 APOE F7 MMP9 MTHFR SELP SPP1

Drugs & Therapeutics for Carotid Stenosis

Drugs for Carotid Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 181)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 113665-84-2, 120202-66-6 60606
2
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
6
Remifentanil Approved Phase 4 132875-61-7 60815
7
Acetaminophen Approved Phase 4 103-90-2 1983
8
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
9 tannic acid Approved Phase 4,Phase 3
10
Benzocaine Approved, Investigational Phase 4,Phase 3 94-09-7, 1994-09-7 2337
11
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
12
Losartan Approved Phase 4 114798-26-4 3961
13
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
14
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
15
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
16 Atorvastatin Calcium Phase 4,Phase 3,Phase 2,Not Applicable 134523-03-8
17 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
19 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
20 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
21 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Anticholesteremic Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
24 Purinergic P2 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
25 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
26 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
27 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Cytochrome P-450 CYP2C19 Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
30 Protective Agents Phase 4,Phase 2,Not Applicable
31 Central Nervous System Depressants Phase 4,Not Applicable
32 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
33 Analgesics Phase 4,Phase 2,Not Applicable
34 Anesthetics Phase 4,Phase 2,Not Applicable
35 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
36 Antipyretics Phase 4,Phase 2,Not Applicable
37 Bronchodilator Agents Phase 4,Not Applicable
38 Anti-Asthmatic Agents Phase 4,Not Applicable
39 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
40 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
41 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
42 Respiratory System Agents Phase 4,Not Applicable
43 Autonomic Agents Phase 4,Not Applicable
44 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
45 Adrenergic alpha-Agonists Phase 4,Not Applicable
46 Adrenergic Agonists Phase 4,Not Applicable
47 Adrenergic Agents Phase 4,Phase 2,Not Applicable
48 Fluorodeoxyglucose F18 Phase 4
49 Radiopharmaceuticals Phase 4
50 Antioxidants Phase 4,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 236)
# Name Status NCT ID Phase Drugs
1 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
2 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
3 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
4 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
5 Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
6 Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy Completed NCT02609087 Phase 4 Sevoflurane;Propofol
7 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
8 Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study) Completed NCT00287508 Phase 4
9 A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
10 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
11 Insulin Resistance in Patients After Carotid Revascularization Recruiting NCT03419767 Phase 4 Melatonin
12 High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
13 Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Active, not recruiting NCT03248401 Phase 4 Cilostazol;Aspirin
14 Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
15 Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA Terminated NCT00478673 Phase 4
16 The Effects of Dexmedetomidine and Remifentanil on Carotid Patients Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
17 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
18 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting Unknown status NCT01331473 Phase 3
19 EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
20 ViVEXX Carotid Revascularization Trial (VIVA) Completed NCT00417963 Phase 3
21 Carotid Artery Stenting With Protection Registry Completed NCT00318851 Phase 3
22 Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects Completed NCT00654394 Phase 3 Rosuvastatin
23 Gadobutrol Enhanced MRA of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
24 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (EMBOLDEN) Completed NCT00766493 Phase 3
25 SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy Completed NCT01591005 Phase 3
26 GORE Embolic Protection With Reverse Flow Completed NCT00594100 Phase 3
27 Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3
28 IMaging Della PLAcca Carotidea Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
29 Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
30 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
31 ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial" Completed NCT00180518 Phase 2, Phase 3
32 Molecular and Clinical Effects of Green Tea and Fermented Papaya Preparation on Diabetes and Cardiovascular Diseases Completed NCT01248143 Phase 2, Phase 3
33 Clopidogrel Resistance and Embolism in Carotid Artery Stenting Recruiting NCT02133989 Phase 3 Ticlopidine + Ginko biloba;Clopidogrel
34 Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes Recruiting NCT02850081 Phase 3 Statin;Atorvastatin
35 " Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke " Not yet recruiting NCT02841098 Phase 3 Optimal medical therapy alone
36 Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis Terminated NCT00126139 Phase 3 Abciximab
37 Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting Terminated NCT00395785 Phase 2, Phase 3
38 Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy Terminated NCT01415648 Phase 3
39 Atherosclerosis Underlying Development Assessed by Intima-Media Thickness in Patients on Rimonabant Terminated NCT00228176 Phase 3 Rimonabant;Placebo (for Rimonabant)
40 Phase II Randomized Placebo-controlled Study With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis Unknown status NCT01923012 Phase 2 Vitamin K2 (Menaquinone)
41 The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Carotid Artery Stenosis Unknown status NCT00904254 Phase 2
42 Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02) Completed NCT01645306 Phase 2 Revacept;Placebo
43 Recurrent Carotid Stenosis Completed NCT00000527 Phase 2 aspirin;dipyridamole
44 Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting Completed NCT01654666 Phase 2
45 Study Effect of VIA-2291 on Atherosclerotic Vascular Inflammation in Patients Undergoing Elective Carotid Endarterectomy Completed NCT00352417 Phase 2 VIA-2291;Placebo
46 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
47 Neuroprotective and Cardioprotective Effects Of Palm Vitamin E Tocotrienols Completed NCT00753532 Phase 2
48 Ticagrelor Versus Clopidogrel in Carotid Artery Stenting Recruiting NCT02677545 Phase 2 Ticagrelor;Clopidogrel;Aspirin
49 Safety and Efficacy of Low Dosage of Terazosin in Subjects Undergoing Carotid Artery Stenting Recruiting NCT03195673 Phase 2 Terazosin
50 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis Recruiting NCT02667457 Phase 2

Search NIH Clinical Center for Carotid Stenosis

Cochrane evidence based reviews: carotid stenosis

Genetic Tests for Carotid Stenosis

Anatomical Context for Carotid Stenosis

MalaCards organs/tissues related to Carotid Stenosis:

41
Brain, Testes, Heart, Liver, Endothelial, Neutrophil, Pituitary

Publications for Carotid Stenosis

Articles related to Carotid Stenosis:

(show top 50) (show all 1957)
# Title Authors Year
1
Symptomatic carotid stenosis and ipsilateral carotid body tumor. ( 29911935 )
2018
2
Carotid stenosis - basing treatment on individual patients' needs. Optimal medical therapy alone or accompanied by stenting or endarterectomy. ( 29064776 )
2018
3
Cyclophilin A: A predictive biomarker of carotid stenosis in cerebral ischemic stroke. ( 29766804 )
2018
4
Comparative analysis of 3D time-resolved contrast-enhanced magnetic resonance angiography, color Doppler ultrasound and digital subtraction angiography in symptomatic carotid stenosis. ( 29434750 )
2018
5
Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial. ( 29861139 )
2018
6
Increased circulating chemerin in patients with advanced carotid stenosis. ( 29653511 )
2018
7
Increased variability of watershed areas in patients with high-grade carotid stenosis. ( 29299616 )
2018
8
The risk of carotid stenosis in head and neck cancer patients after radiation therapy. ( 29706194 )
2018
9
Risk of Stroke or Death Is Associated With the Timing of Carotid Artery Stenting for Symptomatic Carotid Stenosis: A Secondary Data Analysis of the German Statutory Quality Assurance Database. ( 29954748 )
2018
10
Retrospective Study of Hemodynamic Changes Before and After Carotid Stenosis Formation by Vessel Surface Repairing. ( 29615730 )
2018
11
Changes in E-Selectin Levels Predict Carotid Stenosis Progression after Carotid Artery Stenting. ( 29557748 )
2018
12
Carotid Artery Stenting Has a Role in the Management of Asymptomatic Carotid Stenosis, but This Is Currently Small. ( 29390866 )
2018
13
Transatlantic Differences in Management of Carotid Stenosis: BRIDGing the Gap in StrokE Management (BRIDGE) Project. ( 29977441 )
2018
14
Unusual clinical sequalae of Kawasaki disease - symptomatic extracranial Internal carotid stenosis in young adult: A case report. ( 29920397 )
2018
15
Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis. ( 29305337 )
2018
16
Cavernous carotid stenosis following stereotactic radiosurgery for Cushing's disease: A rare complication and review of the literature. ( 29097132 )
2018
17
Neutrophil to Lymphocyte Ratio as a Predictor of Restenosis After Angioplasty and Stenting for Asymptomatic Carotid Stenosis. ( 29940783 )
2018
18
Stroke chameleon (cortical hand syndrome) in a patient with moderate carotid stenosis: a neurological double-trouble. ( 29372407 )
2018
19
Staged carotid artery stenting in patients with severe carotid stenosis: Multicenter experience. ( 29685407 )
2018
20
Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow. ( 29600890 )
2018
21
High intensity signal in the plaque on routine 3D-TOF MRA is associated with ischemic stroke in the patients with low-grade carotid stenosis. ( 29406899 )
2018
22
Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis. ( 29327345 )
2018
23
Risk of Stroke or Death Is Associated With the Timing of Carotid Artery Stenting for Symptomatic Carotid Stenosis: A Secondary Data Analysis of the German Statutory Quality Assurance Database. ( 29588311 )
2018
24
Early Outcomes after Carotid Endarterectomy and Carotid Artery Stenting for Carotid Stenosis in the ACS-NSQIP Database. ( 29922406 )
2018
25
Carotid stenting with proximal cerebral protection in symptomatic low-grade vulnerable recurrent carotid stenosis. ( 29854374 )
2018
26
Factors influencing quality of life in patients followed in the neurosonology laboratory for carotid stenosis. ( 29703211 )
2018
27
Embolic Protection Device in Asymptomatic Carotid Stenosis. ( 29378420 )
2018
28
Accuracy of Carotid Duplex Criteria in Diagnosis of Significant Carotid Stenosis in Asian Patients. ( 29153302 )
2018
29
Emergent treatment of carotid stenosis. A systematic review focused on evidence based medicine. ( 29806753 )
2018
30
Clinical Effect and Cost-Effectiveness of Screening for Asymptomatic Carotid Stenosis: A Markov Model. ( 29636252 )
2018
31
Value of Internal Carotid Artery Stenosis in the Differential Diagnosis between Invasive Pituitary Adenoma and Invasive Meningioma. ( 29532781 )
2018
32
Mitigation of Stroke Risk in Nonvalvular Atrial Fibrillation Patients With High-Grade Carotid Artery Stenosis. ( 30241669 )
2018
33
Severe carotid stenosis and delay of reperfusion in endovascular stroke treatment: an Interventional Management of Stroke-III study. ( 28156253 )
2018
34
Best Medical Treatment for Patients with Carotid Stenosis: Evidence-Based Medicine or Wishful Thinking? ( 28514872 )
2018
35
Severe contralateral carotid stenosis or occlusion does not have an impact on risk of ipsilateral stroke after carotid endarterectomy. ( 29242067 )
2018
36
Increased platelet count and reticulated platelets in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic signal-negative patient subgroups: results from the HaEmostasis In carotid STenosis (HEIST) study. ( 29476243 )
2018
37
Diagnostic yield of 90-kVp low-tube-voltage carotid and intracerebral CT-angiography: effects on radiation dose, image quality and diagnostic performance for the detection of carotid stenosis. ( 29493282 )
2018
38
Systematic Review and Meta-Analysis of Carotid Artery Stenting Versus Endarterectomy for Carotid Stenosis: A Chronological and Worldwide Study: Erratum. ( 29505545 )
2018
39
Comparison of Measurement and Grading of Carotid Stenosis with Computed Tomography Angiography and Doppler Ultrasound. ( 29522870 )
2018
40
Carotid stenosis with impaired brain flow reserve is associated with an increased risk of stroke in on-pump cardiovascular surgery. ( 29529205 )
2018
41
Carotid DSA based CFD simulation in assessing the patient with asymptomatic carotid stenosis: a preliminary study. ( 29530025 )
2018
42
A clinical study and meta-analysis of carotid stenosis with coexistent intracranial aneurysms. ( 29550249 )
2018
43
Targeting Chemokine Receptor CXCR4 and Translocator Protein for Characterization of High-Risk Plaque in Carotid Stenosis Ex Vivo. ( 30002148 )
2018
44
Dynamic change of carotid intraplaque hemorrhage volume in subjects with mild carotid stenosis. ( 30017272 )
2018
45
How to identify which patients with asymptomatic carotid stenosis could benefit from endarterectomy or stenting. ( 30022795 )
2018
46
Association between low levels of serum miR-638 and atherosclerotic plaque vulnerability in patients with high-grade carotid stenosis. ( 30052155 )
2018
47
Carotid endarterectomy versus carotid stenting or best medical treatment in asymptomatic patients with significant carotid stenosis: A meta-analysis. ( 30057288 )
2018
48
Outcomes of Stenting versus Endarterectomy for Symptomatic Extracranial Carotid Stenosis: A Retrospective Multicenter Study in Korea. ( 30092433 )
2018
49
The correlation of asymmetrical functional connectivity with cognition and reperfusion in carotid stenosis patients. ( 30128286 )
2018
50
Carotid revascularization and medical management for asymptomatic carotid stenosis - Hemodynamics (CREST-H): Study design and rationale. ( 30132751 )
2018

Variations for Carotid Stenosis

ClinVar genetic disease variations for Carotid Stenosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RNF213 NM_001256071.2(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 17, 80363699: 80363699
2 RNF213 NM_001256071.2(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 17, 78337499: 78337499

Expression for Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for Carotid Stenosis

GO Terms for Carotid Stenosis

Cellular components related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ACE APOE CRP F7 HABP2 MMP9
2 extracellular matrix GO:0031012 9.46 APOE MMP1 MMP9 TNFRSF11B
3 extracellular region GO:0005576 9.44 ACE APOE CRP F7 HABP2 MMP1

Biological processes related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 ACE F7 HABP2 MMP1 MMP9
2 inflammatory response GO:0006954 9.8 CRP SELP SPP1 TNF
3 negative regulation of gene expression GO:0010629 9.62 ACE APOE CDKN2B-AS1 TNF
4 positive regulation of synaptic transmission GO:0050806 9.51 S100B TNF
5 regulation of neuronal synaptic plasticity GO:0048168 9.48 APOE S100B
6 extracellular matrix organization GO:0030198 9.46 MMP9 SPP1 TNF TNFRSF11B
7 leukocyte tethering or rolling GO:0050901 9.43 SELP TNF
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.4 APOE TNF
9 negative regulation of blood coagulation GO:0030195 9.37 APOE TFPI
10 negative regulation of lipid storage GO:0010888 9.26 CRP TNF
11 leukocyte migration GO:0050900 9.02 MMP1 MMP9 SELP TNF TREM1
12 blood coagulation, extrinsic pathway GO:0007598 8.96 F7 TFPI

Molecular functions related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.65 CRP F7 HABP2 S100B SELP
2 serine-type endopeptidase activity GO:0004252 9.46 F7 HABP2 MMP1 MMP9
3 low-density lipoprotein particle receptor binding GO:0050750 9.37 APOE CRP
4 peptidase activity GO:0008233 9.35 ACE F7 HABP2 MMP1 MMP9
5 tau protein binding GO:0048156 9.32 APOE S100B
6 endopeptidase activity GO:0004175 8.92 ACE F7 MMP1 MMP9

Sources for Carotid Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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