MCID: CRT013
MIFTS: 52

Carotid Stenosis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Stenosis

MalaCards integrated aliases for Carotid Stenosis:

Name: Carotid Stenosis 12 55 44 15 73
Carotid Artery Stenosis 12 6
Carotid Stenosis, Susceptibility to 13
Stenosis, Carotid Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13001
MeSH 44 D016893
NCIt 50 C95804
SNOMED-CT 68 195181000 64586002
UMLS 73 C0007282

Summaries for Carotid Stenosis

MalaCards based summary : Carotid Stenosis, also known as carotid artery stenosis, is related to amaurosis fugax and peripheral vascular disease. An important gene associated with Carotid Stenosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1
Genome-wide association studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD-associated region is adjacent to the two cyclin dependent kinase inhibitors (CDKN)2A and 2B and the last exons of the non-coding RNA,ANRIL.CDKN2A/B and ANRIL (exons 1-2 and 17-18) expression was measured employing RT-PCR.Overall,our results suggest that several CVD-associated SNPs in the 9p21 locus affect the expression of ANRIL,which,in turn modulate cell growth,possibly via CDKN2A/B regulation.
Dysfunction Pattern: Regulation [down-regulated]), and among its related pathways/superpathways are Spinal Cord Injury and TNF signaling pathway. The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually... more...

Related Diseases for Carotid Stenosis

Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 amaurosis fugax 30.7 MMP9 MTHFR
2 peripheral vascular disease 30.2 ACE CRP SELP
3 intermittent claudication 29.9 ACE CRP SELP
4 takayasu arteritis 29.8 CRP MMP9 TNF
5 kawasaki disease 29.7 CRP MMP9 TNF
6 carotid artery disease 29.4 ACE APOE CRP MMP1 MMP9
7 peripheral artery disease 28.7 ACE CDKN2B-AS1 CRP SELP TNFRSF11B
8 ischemic heart disease 28.4 ACE APOE CRP F7 TNF
9 pneumonia 28.4 CRP TNF TREM1
10 heart disease 27.9 ACE APOE CRP F7 MTHFR TNF
11 stroke, ischemic 27.6 ACE APOE CDKN2B-AS1 CRP F7 MTHFR
12 sleep apnea 27.2 ACE APOE CRP ICAM1 S100B TNF
13 arteries, anomalies of 26.8 ACE APOE CRP ICAM1 MMP9 MTHFR
14 vascular disease 26.0 ACE APOE CRP ICAM1 MMP9 MTHFR
15 coronary artery anomaly 25.6 ACE APOE CDKN2B-AS1 CRP F7 ICAM1
16 cerebrovascular disease 25.5 ACE APOE CRP F7 ICAM1 MMP9
17 moyamoya disease 2 11.3
18 moyamoya disease 5 11.1
19 moyamoya disease 6 with achalasia 11.1
20 spastic entropion 10.8 MMP1 MMP9
21 diabetic foot ulcers 10.8 APOE MMP9
22 lentigo maligna melanoma 10.8 MMP9 S100B
23 chronic actinic dermatitis 10.7 MMP1 MMP9
24 osteoporotic fracture 10.7 MTHFR TNFRSF11B
25 moderate and severe traumatic brain injury 10.7 ACE APOE
26 periodontitis, chronic 10.6 MMP1 TNFRSF11B
27 autoimmune inner ear disease 10.6 MMP9 TNF
28 aortic disease 10.6 APOE CRP MMP9
29 odontogenic myxoma 10.6 MMP1 MMP9 S100B
30 uremia 10.5 CRP SPP1 TNFRSF11B
31 chronic meningitis 10.5 CRP MMP9
32 leukomalacia 10.5 SPP1 TNF
33 internal hemorrhoid 10.5 MMP1 MMP9
34 cerebritis 10.5
35 mesenteric vascular occlusion 10.5 F7 MTHFR
36 autoimmune myocarditis 10.4 SPP1 TNF
37 varicose veins 10.4 MMP1 MMP9 MTHFR
38 aortic atherosclerosis 10.4 ACE APOE SPP1
39 hypertensive heart disease 10.4 ACE MMP1 MMP9
40 mastoiditis 10.4 CRP MTHFR
41 exfoliation syndrome 10.4 APOE MMP1 MTHFR
42 portal vein thrombosis 10.4 F7 MTHFR SELP
43 intermediate coronary syndrome 10.4 ACE CRP SELP
44 blood coagulation disease 10.3 F7 MTHFR SELP
45 diverticulitis 10.3 CRP MMP9 TNF
46 ischemic neuropathy 10.3 CRP MTHFR
47 appendicitis 10.3 CRP MMP9 TNF
48 chorioamnionitis 10.3 CRP MMP9 TNF
49 head injury 10.3 APOE S100B
50 systemic scleroderma 10.3 ACE CRP SELP

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to Carotid Stenosis

Symptoms & Phenotypes for Carotid Stenosis

MGI Mouse Phenotypes related to Carotid Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 SELP SPP1 TFPI TNF TREM1 ACE
2 cardiovascular system MP:0005385 10.2 ACE APOE CRP F7 ICAM1 MMP9
3 immune system MP:0005387 10.18 ACE APOE CRP HABP2 ICAM1 MMP1
4 growth/size/body region MP:0005378 10.17 ACE APOE F7 ICAM1 MMP9 MTHFR
5 integument MP:0010771 9.97 APOE ICAM1 MMP9 MTHFR S100B SELP
6 mortality/aging MP:0010768 9.93 TNFRSF11B ACE APOE F7 HABP2 ICAM1
7 limbs/digits/tail MP:0005371 9.73 APOE MMP9 MTHFR TFPI TNF TNFRSF11B
8 neoplasm MP:0002006 9.5 ACE ICAM1 MMP1 MMP9 SPP1 TNF
9 skeleton MP:0005390 9.32 APOE F7 MMP9 MTHFR SELP SPP1

Drugs & Therapeutics for Carotid Stenosis

Drugs for Carotid Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
2
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
6
Acetaminophen Approved Phase 4 103-90-2 1983
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
9
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
10
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
11
Losartan Approved Phase 4 114798-26-4 3961
12
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
13
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
14
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
15 tannic acid Approved, Nutraceutical Phase 4,Phase 3
16 Atorvastatin Calcium Phase 4,Phase 3,Phase 2,Not Applicable 134523-03-8
17 Analgesics Phase 4,Phase 2,Not Applicable
18 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
19 Respiratory System Agents Phase 4,Not Applicable
20 Central Nervous System Depressants Phase 4,Not Applicable
21 Fluorodeoxyglucose F18 Phase 4
22 Adrenergic Agents Phase 4,Phase 2,Not Applicable
23 Adrenergic Agonists Phase 4,Not Applicable
24 Adrenergic alpha-Agonists Phase 4,Not Applicable
25 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
26 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
27 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
28 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
29 Anesthetics Phase 4,Phase 2,Not Applicable
30 Anti-Asthmatic Agents Phase 4,Not Applicable
31 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
32 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
33 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Anticholesteremic Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Protective Agents Phase 4,Phase 2,Not Applicable
37 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
39 Antipyretics Phase 4,Phase 2,Not Applicable
40 Purinergic P2 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
41 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
42 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
43 Radiopharmaceuticals Phase 4
44 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
45 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
46 Autonomic Agents Phase 4,Not Applicable
47 Bronchodilator Agents Phase 4,Not Applicable
48 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
49 Narcotics Phase 4
50 Analgesics, Opioid Phase 4

Interventional clinical trials:

(show top 50) (show all 223)
# Name Status NCT ID Phase Drugs
1 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
2 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
3 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
4 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
5 Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
6 Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy Completed NCT02609087 Phase 4 Sevoflurane;Propofol
7 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
8 Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study) Completed NCT00287508 Phase 4
9 A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
10 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
11 Insulin Resistance in Patients After Carotid Revascularization Recruiting NCT03419767 Phase 4 Melatonin
12 High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
13 Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Recruiting NCT03248401 Phase 4 Cilostazol;Aspirin
14 Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
15 Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA Terminated NCT00478673 Phase 4
16 The Effects of Dexmedetomidine and Remifentanil on Carotid Patients Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
17 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
18 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting Unknown status NCT01331473 Phase 3
19 EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
20 ViVEXX Carotid Revascularization Trial (VIVA) Completed NCT00417963 Phase 3
21 Carotid Artery Stenting With Protection Registry Completed NCT00318851 Phase 3
22 Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects Completed NCT00654394 Phase 3 Rosuvastatin
23 Gadobutrol Enhanced MRA of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
24 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (EMBOLDEN) Completed NCT00766493 Phase 3
25 SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy Completed NCT01591005 Phase 3
26 GORE Embolic Protection With Reverse Flow Completed NCT00594100 Phase 3
27 Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3
28 IMaging Della PLAcca Carotidea Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
29 Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
30 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
31 ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial" Completed NCT00180518 Phase 2, Phase 3
32 Molecular and Clinical Effects of Green Tea and Fermented Papaya Preparation on Diabetes and Cardiovascular Diseases Completed NCT01248143 Phase 2, Phase 3
33 Clopidogrel Resistance and Embolism in Carotid Artery Stenting Recruiting NCT02133989 Phase 3 Ticlopidine + Ginko biloba;Clopidogrel
34 Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes Recruiting NCT02850081 Phase 3 Statin;Atorvastatin
35 " Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke " Not yet recruiting NCT02841098 Phase 3 Optimal medical therapy alone
36 Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis Terminated NCT00126139 Phase 3 Abciximab
37 Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting Terminated NCT00395785 Phase 2, Phase 3
38 Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy Terminated NCT01415648 Phase 3
39 Atherosclerosis Underlying Development Assessed by Intima-Media Thickness in Patients on Rimonabant Terminated NCT00228176 Phase 3 Rimonabant;Placebo (for Rimonabant)
40 Phase II Randomized Placebo-controlled Study With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis Unknown status NCT01923012 Phase 2 Vitamin K2 (Menaquinone)
41 The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Carotid Artery Stenosis Unknown status NCT00904254 Phase 2
42 Recurrent Carotid Stenosis Completed NCT00000527 Phase 2 aspirin;dipyridamole
43 Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting Completed NCT01654666 Phase 2
44 Study Effect of VIA-2291 on Atherosclerotic Vascular Inflammation in Patients Undergoing Elective Carotid Endarterectomy Completed NCT00352417 Phase 2 VIA-2291;Placebo
45 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
46 Neuroprotective and Cardioprotective Effects Of Palm Vitamin E Tocotrienols Completed NCT00753532 Phase 2
47 Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02) Recruiting NCT01645306 Phase 2 Revacept;Placebo
48 Ticagrelor Versus Clopidogrel in Carotid Artery Stenting Recruiting NCT02677545 Phase 2 Ticagrelor;Clopidogrel;Aspirin
49 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis Recruiting NCT02667457 Phase 2
50 New Technologies to Determine Carotid Plaque Vulnerability in Patients With Significant Carotid Plaques Recruiting NCT03335033 Phase 2

Search NIH Clinical Center for Carotid Stenosis

Cochrane evidence based reviews: carotid stenosis

Genetic Tests for Carotid Stenosis

Anatomical Context for Carotid Stenosis

MalaCards organs/tissues related to Carotid Stenosis:

41
Brain, Heart, Endothelial, Eye, Liver, Myeloid, Neutrophil

Publications for Carotid Stenosis

Articles related to Carotid Stenosis:

(show top 50) (show all 690)
# Title Authors Year
1
Symptomatic carotid stenosis and ipsilateral carotid body tumor. ( 29911935 )
2018
2
Carotid stenosis - basing treatment on individual patients' needs. Optimal medical therapy alone or accompanied by stenting or endarterectomy. ( 29064776 )
2018
3
Cyclophilin A: A predictive biomarker of carotid stenosis in cerebral ischemic stroke. ( 29766804 )
2018
4
Comparative analysis of 3D time-resolved contrast-enhanced magnetic resonance angiography, color Doppler ultrasound and digital subtraction angiography in symptomatic carotid stenosis. ( 29434750 )
2018
5
Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial. ( 29861139 )
2018
6
Increased circulating chemerin in patients with advanced carotid stenosis. ( 29653511 )
2018
7
Increased variability of watershed areas in patients with high-grade carotid stenosis. ( 29299616 )
2018
8
The risk of carotid stenosis in head and neck cancer patients after radiation therapy. ( 29706194 )
2018
9
Risk of Stroke or Death Is Associated With the Timing of Carotid Artery Stenting for Symptomatic Carotid Stenosis: A Secondary Data Analysis of the German Statutory Quality Assurance Database. ( 29954748 )
2018
10
Retrospective Study of Hemodynamic Changes Before and After Carotid Stenosis Formation by Vessel Surface Repairing. ( 29615730 )
2018
11
Changes in E-Selectin Levels Predict Carotid Stenosis Progression after Carotid Artery Stenting. ( 29557748 )
2018
12
Carotid Artery Stenting Has a Role in the Management of Asymptomatic Carotid Stenosis, but This Is Currently Small. ( 29390866 )
2018
13
Transatlantic Differences in Management of Carotid Stenosis: BRIDGing the Gap in StrokE Management (BRIDGE) Project. ( 29977441 )
2018
14
Unusual clinical sequalae of Kawasaki disease - symptomatic extracranial Internal carotid stenosis in young adult: A case report. ( 29920397 )
2018
15
Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis. ( 29305337 )
2018
16
Cavernous carotid stenosis following stereotactic radiosurgery for Cushing's disease: A rare complication and review of the literature. ( 29097132 )
2018
17
Neutrophil to Lymphocyte Ratio as a Predictor of Restenosis After Angioplasty and Stenting for Asymptomatic Carotid Stenosis. ( 29940783 )
2018
18
Stroke chameleon (cortical hand syndrome) in a patient with moderate carotid stenosis: a neurological double-trouble. ( 29372407 )
2018
19
Staged carotid artery stenting in patients with severe carotid stenosis: Multicenter experience. ( 29685407 )
2018
20
Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow. ( 29600890 )
2018
21
High intensity signal in the plaque on routine 3D-TOF MRA is associated with ischemic stroke in the patients with low-grade carotid stenosis. ( 29406899 )
2018
22
Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis. ( 29327345 )
2018
23
Risk of Stroke or Death Is Associated With the Timing of Carotid Artery Stenting for Symptomatic Carotid Stenosis: A Secondary Data Analysis of the German Statutory Quality Assurance Database. ( 29588311 )
2018
24
Early Outcomes after Carotid Endarterectomy and Carotid Artery Stenting for Carotid Stenosis in the ACS-NSQIP Database. ( 29922406 )
2018
25
Carotid stenting with proximal cerebral protection in symptomatic low-grade vulnerable recurrent carotid stenosis. ( 29854374 )
2018
26
Factors influencing quality of life in patients followed in the neurosonology laboratory for carotid stenosis. ( 29703211 )
2018
27
Embolic Protection Device in Asymptomatic Carotid Stenosis. ( 29378420 )
2018
28
Accuracy of Carotid Duplex Criteria in Diagnosis of Significant Carotid Stenosis in Asian Patients. ( 29153302 )
2018
29
Emergent treatment of carotid stenosis. A systematic review focused on evidence based medicine. ( 29806753 )
2018
30
Clinical Effect and Cost-Effectiveness of Screening for Asymptomatic Carotid Stenosis: A Markov Model. ( 29636252 )
2018
31
Surgical Treatment of Significant Asymptomatic Carotid Stenosis: for the Motion. ( 28985661 )
2017
32
Carotid Stenosis and Impaired Cognition: The Effect of Intervention. ( 28786896 )
2017
33
Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels. ( 28495179 )
2017
34
Reply to Letter to the Editor "Carotid Endarterectomy Versus Stenting to Treat Carotid Stenosis: There is More to Than Meets the Eye". ( 28742693 )
2017
35
Mesh-covered (Roadsaver) stent as a new treatment modality for symptomatic or high-risk carotid stenosis. ( 28798783 )
2017
36
Increased expression of TFPI in human carotid stenosis. ( 28482260 )
2017
37
Prolonged cerebral circulation time is more associated with symptomatic carotid stenosis than stenosis degree or collateral circulation. ( 28855347 )
2017
38
Influence of Severe Carotid Stenosis on Cognition, Depressive Symptoms and Quality of Life. ( 29238393 )
2017
39
Asymptomatic carotid stenosis is associated with cognitiveA impairment. ( 28712815 )
2017
40
3-Dimensional Ultrasound in Carotid Stenosis Quantitation and Beyond. ( 28734910 )
2017
41
The risk of ischemic events increased in patients with asymptomatic carotid stenosis with decreased cerebrovascular reserve. ( 28716984 )
2017
42
The Impact of Carotid Artery Stenting on Cerebral Perfusion, Functional Connectivity, and Cognition in Severe Asymptomatic Carotid Stenosis Patients. ( 28848495 )
2017
43
Recommendations for Low-Grade Carotid Stenosis Follow-up Based on a Single-Institution Database. ( 28877387 )
2017
44
Pooled RCTs: In symptomatic carotid stenosis, endarterectomy had lower periprocedural risk than stenting. ( 29049764 )
2017
45
Mild Carotid Stenosis with Recurrent Symptoms Triggered by Eating. ( 27989985 )
2017
46
Which patients with asymptomatic carotid stenosis benefit from revascularization? ( 27875340 )
2017
47
Carotid Endarterectomy Versus Carotid Stenting to Treat Carotid Stenosis: There Is More to Than Meets the Eye. ( 28742705 )
2017
48
Symptomatic carotid stenosis: is stenting as safe and effective as carotid endarterectomy? ( 28002121 )
2017
49
Ethnicity, Race, and Post-Operative Stroke Risk among 53,593 Patients with Asymptomatic Carotid Stenosis Undergoing Revascularization. ( 28890012 )
2017
50
Extracranial carotid stenosis: evidence based review. ( 28767806 )
2017

Variations for Carotid Stenosis

ClinVar genetic disease variations for Carotid Stenosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RNF213 NM_001256071.2(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 17, 80363699: 80363699
2 RNF213 NM_001256071.2(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 17, 78337499: 78337499

Expression for Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for Carotid Stenosis

GO Terms for Carotid Stenosis

Cellular components related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ACE APOE CRP F7 HABP2 MMP1
2 external side of plasma membrane GO:0009897 9.56 ACE ICAM1 SELP TNF
3 extracellular matrix GO:0031012 9.46 APOE ICAM1 MMP1 MMP9
4 extracellular space GO:0005615 9.44 ACE APOE CRP F7 HABP2 ICAM1

Biological processes related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 ICAM1 MMP1 MMP9 TNF
2 response to lipopolysaccharide GO:0032496 9.67 ICAM1 SELP TFPI TNFRSF11B
3 inflammatory response GO:0006954 9.65 CRP SELP SPP1 TNF TNFRSF11B
4 extracellular matrix disassembly GO:0022617 9.61 MMP1 MMP9 SPP1
5 leukocyte tethering or rolling GO:0050901 9.51 SELP TNF
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.48 APOE TNF
7 negative regulation of blood coagulation GO:0030195 9.46 APOE TFPI
8 negative regulation of lipid storage GO:0010888 9.4 CRP TNF
9 extracellular matrix organization GO:0030198 9.35 ICAM1 MMP9 SPP1 TNF TNFRSF11B
10 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.32 ICAM1 TNF
11 blood coagulation, extrinsic pathway GO:0007598 9.16 F7 TFPI
12 leukocyte migration GO:0050900 9.1 ICAM1 MMP1 MMP9 SELP TNF TREM1

Molecular functions related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.72 CRP F7 HABP2 S100B SELP
2 serine-type endopeptidase activity GO:0004252 9.46 F7 HABP2 MMP1 MMP9
3 peptidase activity GO:0008233 9.35 ACE F7 HABP2 MMP1 MMP9
4 tau protein binding GO:0048156 9.26 APOE S100B
5 endopeptidase activity GO:0004175 8.92 ACE F7 MMP1 MMP9

Sources for Carotid Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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