Carotid Stenosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRT013 MIFTS: 50	Carotid Stenosis Categories: Cardiovascular diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Carotid Stenosis

MalaCards integrated aliases for Carotid Stenosis:

Name: Carotid Stenosis ¹² ⁵⁴ ⁴³ ¹⁵ ⁷¹

Carotid Artery Stenosis ¹² ⁶ ¹⁵

Stenosis, Carotid Artery ¹²

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13001

MeSH ⁴³ D016893

NCIt ⁴⁹ C95804

SNOMED-CT ⁶⁷ 64586002

UMLS ⁷¹ C0007282

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Summaries for Carotid Stenosis

MalaCards based summary : Carotid Stenosis, also known as carotid artery stenosis, is related to amaurosis fugax and hypercholesterolemia, familial, 1. An important gene associated with Carotid Stenosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Development VEGF signaling via VEGFR2 - generic cascades. The drugs Simvastatin and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : ⁷⁴ Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually... more...

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Related Diseases for Carotid Stenosis

Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 505)

#	Related Disease	Score	Top Affiliating Genes
1	amaurosis fugax	31.5	MTHFR MMP9
2	hypercholesterolemia, familial, 1	30.8	NOS3 LPA CRP APOE ACE
3	carotid artery disease	30.7	SELP SELE MMP9 MMP1 LPA CRP
4	coronary stenosis	30.6	ICAM1 CRP APOE ACE
5	lipid metabolism disorder	30.6	SELE LPA CRP APOE ACE
6	chlamydia pneumonia	30.6	TNF CRP APOE
7	mitral valve stenosis	30.5	SELP CRP ACE
8	silent myocardial infarction	30.5	LPA CRP ACE
9	atrial fibrillation	30.5	SELP NOS3 CRP ACE
10	central sleep apnea	30.5	NOS3 CRP ACE
11	generalized atherosclerosis	30.4	LPA CRP APOE ACE
12	aortic aneurysm	30.4	MMP9 CRP CDKN2B-AS1 APOE ACE
13	arteriovenous malformation	30.4	TNF MMP9 APOE
14	tolosa-hunt syndrome	30.4	CRP ACE
15	peripheral vascular disease	30.4	VCAM1 SELP SELE NOS3 LPA CRP
16	moyamoya disease 1	30.4	MTHFR MMP9 LPA
17	cholesteatoma of middle ear	30.3	TNFRSF11B MMP9 MMP1 ICAM1
18	arteriosclerosis obliterans	30.3	VCAM1 SELP MMP9 ICAM1
19	familial hyperlipidemia	30.3	LPA CRP APOE ACE
20	intermittent claudication	30.3	SELP CRP ACE
21	retinal vein occlusion	30.3	TNF MTHFR ACE
22	angina pectoris	30.3	NOS3 LPA CRP ACE
23	mitral valve disease	30.3	NOS3 MMP1 CRP ACE
24	neuroretinitis	30.2	CRP ACE
25	intermediate coronary syndrome	30.2	VCAM1 SELP LPA ICAM1 CRP ACE
26	hepatic encephalopathy	30.2	TNF S100B MMP9
27	aortic disease	30.2	MMP9 CRP APOE ACE
28	homocysteinemia	30.2	VCAM1 NOS3 MTHFR CRP APOE
29	microvascular complications of diabetes 5	30.1	VCAM1 NOS3 ICAM1 ACE
30	nonarteritic anterior ischemic optic neuropathy	30.1	NOS3 MTHFR CRP ACE
31	end stage renal failure	30.1	TNF SELP CRP ACE
32	microvascular complications of diabetes 1	30.1	VCAM1 MMP9 ICAM1
33	intracranial aneurysm	30.1	TNF NOS3 CDKN2B-AS1 APOE ACE
34	heart valve disease	30.1	LPA CRP ACE
35	aortic valve disease 2	30.1	TNFRSF11B SPP1 NOS3 LPA CRP ACE
36	colorectal adenoma	30.1	TNF MTHFR MMP9 CRP
37	tetralogy of fallot	30.0	MTHFR MMP9 CRP APOE ACE
38	pulmonary disease, chronic obstructive	30.0	TNF MMP9 MMP1 CRP ACE
39	retinal vascular occlusion	30.0	SELP MTHFR LPA ICAM1 CRP
40	aortic aneurysm, familial abdominal, 1	29.9	TNFRSF11B MMP9 MMP1 CRP CDKN2B-AS1 APOE
41	kawasaki disease	29.9	TNF SELE MMP9 CRP
42	cerebral atherosclerosis	29.8	MTHFR LPA CRP APOE ACE
43	hypothyroidism	29.8	TNFRSF11B TNF LPA CRP APOE ACE
44	migraine with or without aura 1	29.7	TNF NOS3 MTHFR CRP ACE
45	systolic heart failure	29.7	TNF NOS3 MMP9 MMP1 CRP ACE
46	cerebral arterial disease	29.7	S100B NOS3 MMP9 CDKN2B-AS1
47	vasculitis	29.7	VCAM1 TNF SELP SELE ICAM1 CRP
48	patent foramen ovale	29.7	MTHFR LPA F7 CRP ACE
49	retinal vascular disease	29.6	VCAM1 TNF NOS3 MTHFR ICAM1 CRP
50	proteasome-associated autoinflammatory syndrome 1	29.6	VCAM1 TNF SELP SELE MMP9 ICAM1

Graphical network of the top 20 diseases related to Carotid Stenosis:

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Symptoms & Phenotypes for Carotid Stenosis

MGI Mouse Phenotypes related to Carotid Stenosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.3	ACE APOE CRP F7 HABP2 ICAM1
2	growth/size/body region	MP:0005378	10.28	ACE APOE F7 ICAM1 MMP9 MTHFR
3	cardiovascular system	MP:0005385	10.27	ACE APOE CRP F7 ICAM1 MMP9
4	immune system	MP:0005387	10.17	ACE APOE CRP HABP2 ICAM1 MMP1
5	hematopoietic system	MP:0005397	10.14	ACE APOE ICAM1 MMP9 NOS3 SELE
6	integument	MP:0010771	9.91	APOE ICAM1 MMP9 MTHFR S100B SELE
7	liver/biliary system	MP:0005370	9.85	ACE APOE HABP2 MTHFR NOS3 SELE
8	mortality/aging	MP:0010768	9.8	ACE APOE F7 HABP2 ICAM1 MMP9
9	vision/eye	MP:0005391	9.28	APOE ICAM1 MMP9 MTHFR NOS3 SELE

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Drugs & Therapeutics for Carotid Stenosis

Drugs for Carotid Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 186)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Simvastatin

Approved

Phase 4

79902-63-9

54454

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Desflurane

Approved

Phase 4

57041-67-5

42113

Nicotinamide

Approved, Investigational

Phase 4

98-92-0

936

Acetaminophen

Approved

Phase 4

103-90-2

1983

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Evolocumab

Approved

Phase 4

1256937-27-5

Losartan

Approved

Phase 4

114798-26-4

3961

Amlodipine

Approved

Phase 4

88150-42-9

2162

Atorvastatin

Approved

Phase 4

134523-00-5

60823

Remifentanil

Approved

Phase 4

132875-61-7

60815

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

68602 5311068

tannic acid

Approved

Phase 4

1401-55-4

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 4

59-30-3

6037

Niacin

Approved, Investigational, Nutraceutical

Phase 4

59-67-6

938

Melatonin

Approved, Nutraceutical, Vet_approved

Phase 4

73-31-4

896

Calcium

Approved, Nutraceutical

Phase 4

7440-70-2

271

Anesthetics, Inhalation

Phase 4

Micronutrients

Phase 4

Vitamins

Phase 4

Trace Elements

Phase 4

Nutrients

Phase 4

Vitamin B3

Phase 4

Vitamin B Complex

Phase 4

Vitamin B9

Phase 4

Folate

Phase 4

Nicotinic Acids

Phase 4

Antibodies, Monoclonal

Phase 4

Immunoglobulins

Phase 4

Antibodies

Phase 4

Immunologic Factors

Phase 4

Protective Agents

Phase 4

Antioxidants

Phase 4

Hypoglycemic Agents

Phase 4

insulin

Phase 4

Insulin, Globin Zinc

Phase 4

Neurotransmitter Agents

Phase 4

Adrenergic Agents

Phase 4

Hypolipidemic Agents

Phase 4

Anticholesteremic Agents

Phase 4

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 4

Calcium, Dietary

Phase 4

Lipid Regulating Agents

Phase 4

Antimetabolites

Phase 4

Anesthetics

Phase 4

Anti-Arrhythmia Agents

Phase 4

Hormones

Phase 4

Vasodilator Agents

Phase 4

Interventional clinical trials:

(show top 50) (show all 281)

#	Name	Status	NCT ID	Phase	Drugs
1	Early Warning and Optimization Strategy in Carotid Endarterectomy	Unknown status	NCT01210937	Phase 4
2	Comparison of Staged Angioplasty v.s. Routine Single-stage Stenting (CAS) in the Treatment of Patients With Carotid Artery Stenosis at High Risk of Hyperperfusion (STEP）: A Randomized Controlled Trial	Unknown status	NCT02224209	Phase 4
3	Efficacy of Two Different Pre-Intervention Therapeutic Strategies With Clopidogrel and Atorvastatin for the Prevention of Cerebral Damage During Carotid Artery Stenting. Armyda-Caro Randomized Trial.	Unknown status	NCT01572623	Phase 4	Clopidogrel;Atorvastatin
4	A Randomized Evaluation of Short Term and Long Term Outcome After Endovascular Repair by Stenting of Carotid Artery Stenosis in Patients With Severe (70% and Higher) Asymptomatic Carotid Stenosis	Completed	NCT00772278	Phase 4
5	Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWire™ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System	Completed	NCT00287508	Phase 4
6	Time to Post-Anesthesia Neurological Evaluation and Hemodynamic Stability in Carotid Endarterectomy Comparing Three General Anesthetic Techniques Targeted to a Preset Bispectral Index Value: a Pilot Study	Completed	NCT03996148	Phase 4	Remifentanil, Propofol, and Desflurane;Remifentanil, Dexmedetomidine, and Desflurane;Remifentanil and Desflurane
7	Does the Magnitude of Platelet Inhibition Inversely Correlate With the Number of TCD-detected Microemboli in Asymptomatic Patients Undergoing Carotid Artery Stenting Prior to Cardiac Surgery Who Are Being Pre-treated With 300 mg or 600 mg Loading Dose of Clopidogrel?	Completed	NCT01146301	Phase 4	Clopidogrel
8	A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease	Completed	NCT00178672	Phase 4
9	Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology	Completed	NCT00307307	Phase 4	Niacin/simvastatin compared to simvastatin alone at 2 doses
10	Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit	Completed	NCT01948505	Phase 4	Intravenous acetaminophen;Placebo for IV acetaminophen
11	Comparison the Effect on Cerebral Oxygenation by Sevoflurane-remifentanil or Propofol-remifentanil Anesthesia Using Near-infrared Spectroscopy in Patients Undergoing Carotid Endarterectomy)	Completed	NCT02609087	Phase 4	Sevoflurane;Propofol
12	The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy	Completed	NCT03115034	Phase 4	Melatonin;placebo
13	Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis	Recruiting	NCT03931161	Phase 4	Evolocumab Auto-Injector [Repatha];Placebo Auto-Injector
14	Efficacy of Two Different Doses of Atorvastatin for Prevention of Periprocedural Ischemic Brain Damage in Chinese Patients Undergoing Carotid Artery Stenting (CAS)	Recruiting	NCT03079115	Phase 4	High-dose Atorvastatin;Conventional-dose Atorvastatin
15	The Problem of Insulin Resistance in Patients After Carotid Revascularization	Recruiting	NCT03419767	Phase 4	Melatonin
16	Carotid Endarterectomy Versus Optimal Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis	Terminated	NCT00805311	Phase 4	atorvastatin, aspirin, losartan, amlodipine
17	Phase 4: The Effects of Dexmedetomidine and Remifentanil on Postoperative Hemodynamics and Pain/Opioids in Patients Undergoing Carotid Endarterectomy	Terminated	NCT00335972	Phase 4	Remifentanil;Dexmedetomidine
18	The NexStent® Carotid Stent System: A Post Market Approval Evaluation Study In Conjunction With the FilterWire EZ™ Embolic Protection System	Terminated	NCT00478673	Phase 4
19	Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease	Terminated	NCT01236508	Phase 4
20	PROximal Protection VErsus NON-Protection in Carotid Artery Stenting (PROVENON Study) A Randomized Prospective MRI-based Trial.	Unknown status	NCT01331473	Phase 3
21	Ticlopidine+Ginkgo Biloba Versus Clopidogrel in Clopidogrel Resistant Patients Undergoing Cartoid Artery Stent Placement	Unknown status	NCT02133989	Phase 3	Ticlopidine + Ginko biloba;Clopidogrel
22	The Embolic Protection With Reverse Flow Study of the GORE Neuro Protection System in Carotid Stenting of Subjects At High Risk for Carotid Endarterectomy	Completed	NCT00594100	Phase 3
23	GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (GORE EMBOLDEN)	Completed	NCT00766493	Phase 3
24	Randomized, Double-Blind, Multicenter, Trial to Assess the Effect of High & Low Doses of ZD4522 on Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects With Asymptomatic Carotid Stenosis After 24 Months of Dosing.	Completed	NCT00654394	Phase 3	Rosuvastatin
25	The ViVEXX Carotid Revascularization Trial (VIVA) for High Surgical Risk Patients With Extracranial Carotid Artery Stenosis Using the Bard ViVEXX Carotid Stent and Emboshield BareWire Rapid Exchange Embolic Protection System	Completed	NCT00417963	Phase 3
26	Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis	Completed	NCT00190398	Phase 3
27	Treatment of Carotid Stenosis With Carotid Stenting and Neurologic Protection With Pre-Procedure and Follow-Up With MRI DIffusion Imaging and Neuropsychological Testing	Completed	NCT00318851	Phase 3
28	CLEAR-ROAD; a Physician-initiated Carotid Trial Investigating the Efficacy of Endovascular Treatment of Carotid Arterial Disease With the Multi-layer RoadSaver Stent	Completed	NCT02529345	Phase 2, Phase 3
29	Risk Reduction of Symptomatic and Silent Brain Infarctions During Carotid Endarterectomy and Carotid Stenting Due to Ultrasound Activation of Endogenous Fibrinolytic System Using Transcranial Doppler Monitoring	Completed	NCT01591005	Phase 3
30	Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis	Completed	NCT03333330	Phase 3	Visipaque 320 and SonoVue
31	Randomized Controlled Trial Analyzing the Role of Systematic Preoperative Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease	Completed	NCT02260453	Phase 3
32	Multicenter, Open-label Study to Evaluate the Safety and Efficacy (by Blinded Reading) of Contrast-Enhanced Magnetic Resonance Angiography (MRA) After a Single Intravenous Injection of 0.1 mmol/kg Gadobutrol in Subjects With Known or Suspected Vascular Disease of the Supra-aortic Vessels	Completed	NCT01344447	Phase 3	Gadobutrol (Gadovist, BAY86-4875)
33	Prospective, Non-Randomized, Multi-Center, Single-Arm Trial to Assess Safety & Efficacy of the Acculink Carotid Stent System With the Accunet Embolic Protection System in High-Risk Patients With Carotid Artery Lesions.	Completed	NCT00180518	Phase 2, Phase 3
34	Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER)	Completed	NCT00109382	Phase 2, Phase 3	Aspirin;Clopidogrel;Simvastatin
35	Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes	Recruiting	NCT02850081	Phase 3	Statin;Atorvastatin
36	99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques	Not yet recruiting	NCT03630835	Phase 2, Phase 3
37	Abciximab Versus Aspirin for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic >50% Carotid Stenosis: A Pilot Study (ASTERICS)	Terminated	NCT00126139	Phase 3	Abciximab
38	Protection During Carotid Stenting in High Risk Patients With the TriActiv ProGuard System	Terminated	NCT00395785	Phase 2, Phase 3
39	Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy.	Terminated	NCT01415648	Phase 3
40	Randomized, Multicenter, Double-blind, Placebo-controlled, Two-arm Parallel Group Trial of Rimonabant 20-mg od, for Inhibition of Atherosclerosis Progression Assessed by Carotid Artery Intima-media Thickness (CIMT), in Overweight Patients With Additional Risk Factors	Terminated	NCT00228176	Phase 3	Rimonabant;Placebo (for Rimonabant)
41	The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Asymptomatic and Symptomatic Carotid Artery Stenosis - an Open Proof of Concept Study.	Unknown status	NCT00904254	Phase 2
42	Phase 2 Study Randomized Placebo Controlled With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis	Unknown status	NCT01923012	Phase 2	Vitamin K2 (Menaquinone)
43	Tissue Kallikrein Preventing the Restenosis After Stenting of Symptomatic MCA Atherosclerotic Stenosis	Unknown status	NCT01558245	Phase 2	tissue kallikrein
44	Randomized Controlled Clinical Study on Vulnerable Plaque of Carotid Artery With Chinese Herbal and Insects Medicine	Unknown status	NCT03072225	Phase 2	Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
45	Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Phase II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo Controlled Superiority Study With Parallel Groups	Completed	NCT01645306	Phase 2	Revacept;Placebo
46	Recurrent Carotid Stenosis	Completed	NCT00000527	Phase 2	aspirin;dipyridamole
47	Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting	Completed	NCT01654666	Phase 2
48	A Phase 2 Randomized, Double-blind, Placebo-controlled Study of the Effects of VIA-2291, a 5-Lipoxygenase Inhibitor, on Atherosclerotic Plaque and Biomarkers of Vascular Inflammation in Patients With Carotid Stenosis Undergoing Elective Carotid Endarterectomy	Completed	NCT00352417	Phase 2	VIA-2291;Placebo
49	A Double Blind Placebo Controlled Study On The Neuroprotective And Anti-Atherogenic Effects Of Palm TocotrienolRich Fraction(Palm Vitamin E)	Completed	NCT00753532	Phase 2
50	Asymptomatic Carotid Artery Plaque Study (ACAPS)	Completed	NCT00000469	Phase 2	aspirin;lovastatin

Search NIH Clinical Center for Carotid Stenosis

Cochrane evidence based reviews: carotid stenosis

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Genetic Tests for Carotid Stenosis

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Anatomical Context for Carotid Stenosis

MalaCards organs/tissues related to Carotid Stenosis:

⁴⁰

Brain, Heart, Testes, Endothelial, Bone, Kidney, Liver

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Publications for Carotid Stenosis

Articles related to Carotid Stenosis:

(show top 50) (show all 9169)

#	Title	Authors	PMID	Year
1	Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. ⁵⁴ ⁶¹	Cozzolino M...Gallieni M	19221176	2009
2	Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study. ⁵⁴ ⁶¹	Romero JR...Seshadri S	18984437	2008
3	Markers of instability in high-risk carotid plaques are reduced by statins. ⁵⁴ ⁶¹	Kunte H...Harms L	18295103	2008
4	Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP. ⁵⁴ ⁶¹	Stephan S...Vitzthum F	18605956	2008
5	High serum level of matrix metalloproteinase-1 and its rapid surge after intervention in patients with significant carotid atherosclerosis. ⁵⁴ ⁶¹	Wu YW...Kao HL	18218585	2008
6	Metalloproteinase expression in carotid plaque and its correlation with plasma levels before and after carotid endarterectomy. ⁵⁴ ⁶¹	Taurino M...Faraglia V	18166633	2007
7	Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis. ⁵⁴ ⁶¹	Zalba G...Diez J	17194891	2007
8	Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1. ⁵⁴ ⁶¹	Wu YW...Yang WS	17268019	2007
9	Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis. ⁵⁴ ⁶¹	Eldrup N...Nordestgaard BG	17030690	2006
10	Polymorphisms in the PON gene cluster are associated with Alzheimer disease. ⁵⁴ ⁶¹	Erlich PM...MIRAGE Study Group	16319130	2006
11	Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis. ⁵⁴ ⁶¹	McCabe DJ...Brown MM	16107361	2005
12	Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism. ⁵⁴ ⁶¹	Hoppe B...Salama A	15486068	2005
13	Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis. ⁵⁴ ⁶¹	Alvarez B...Matas M	15337875	2004
14	Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells. ⁵⁴ ⁶¹	Kannemeier C...Kanse SM	14977886	2004
15	Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis. ⁵⁴ ⁶¹	Willeit J...Roemisch J	12578864	2003
16	Serial measurement of surface expressions of CD63, P-selectin and CD40 ligand on platelets in atherosclerotic ischemic stroke. A possible role of CD40 ligand on platelets in atherosclerotic ischemic stroke. ⁵⁴ ⁶¹	Cha JK...Kim JW	13130179	2003
17	Thrombocyte activation increases with the degree of carotid artery stenosis. ⁵⁴ ⁶¹	Stolz E...Kaps M	17903894	2002
18	Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. ⁵⁴ ⁶¹	Ghilardi G...Scorza R	12364729	2002
19	Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease. ⁵⁴ ⁶¹	Topic E...Zuntar I	11388660	2001
20	Duplex Criteria for Grading of External Carotid Stenosis. ⁶¹	Shmelev A...Zatina M	31563656	2020
21	Concomitant carotid endarterectomy and aortic valve replacement in a patient with high risk of perioperative stroke. ⁶¹	Saito S...Ushijima T	30443815	2020
22	Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study. ⁶¹	Tancin Lambert A...Aamodt AH	32028277	2020
23	An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models. ⁶¹	Foddis M...Sassi C	31549895	2020
24	Light-induced amaurosis - a case report and brief literature review. ⁶¹	Tsai J...Tsai S	32027984	2020
25	Risk of perioperative neck hematoma in TIA and non-disabling stroke patients with symptomatic carotid artery stenosis undergoing endarterectomy within 14 days from cerebrovascular event. ⁶¹	Roussopoulou A...Vasdekis SN	31811985	2020
26	The impact of pre-operative symptoms on carotid endarterectomy Outcomes: Analysis of the ACS-NSQIP carotid endarterectomy database. ⁶¹	Shah VS...Powers CJ	32019726	2020
27	Blood Flow Pattern Analysis for Carotid Plaque Evaluation. ⁶¹	Shimonaga K...Kurisu K	31810722	2020
28	Surgical repair of radiation-induced carotid stenosis. ⁶¹	Renard R...Koskas F	32035779	2020
29	Microglial Hv1 proton channels promote white matter injuries after chronic hypoperfusion in mice. ⁶¹	Yu Y...Wang W	31769505	2020
30	Safety of simultaneous bilateral carotid artery stenting for bilateral carotid artery stenosis. ⁶¹	Oshita J...Kurisu K	31423862	2020
31	Nationwide Trends in Carotid Endarterectomy and Carotid Artery Stenting in the Post-CREST Era. ⁶¹	Cole TS...Ducruet AF	31847750	2020
32	Contrast-enhanced ultrasound perfusion patterns and serum lipid signatures of vulnerable carotid artery plaque in predicting stroke: A cohort study of carotid stenosis in Chinese patients. ⁶¹	Huang Y...Chen M	32039838	2020
33	The stronger one-sided relative hypoperfusion, the more pronounced ipsilateral spatial attentional bias in patients with asymptomatic carotid stenosis. ⁶¹	Gottler J...Sorg C	30480463	2020
34	Association Between Systemic Inflammation, Carotid Arteriosclerosis, and Autonomic Dysfunction. ⁶¹	Rupprecht S...Schwab M	31093927	2020
35	Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data. ⁶¹	Schindler A...Saam T	31202755	2020
36	Confounding of Cerebral Blood Flow Velocity by Blood Pressure During Breath Holding or Hyperventilation in Transient Ischemic Attack or Stroke. ⁶¹	Webb AJS...Oxford Vascular Study Phenotyped Cohort	31884903	2020
37	Incidence and predictors of calcified cerebral emboli detected in patients who underwent endovascular procedures. ⁶¹	Maeda T...Kohyama S	32036266	2020
38	Symptomatic carotid near-occlusion causes a high risk of recurrent ipsilateral ischemic stroke. ⁶¹	Gu T...Johansson E	31701329	2020
39	A comparison of outcomes of eversion versus conventional carotid endarterectomy: one centre experience. ⁶¹	Maguire SC...Sheehan SJ	31102071	2020
40	Intracranial calcifications under vitamin K antagonists or direct oral anticoagulants: Results from the French VIKING study in older adults. ⁶¹	Annweiler G...SAM group	31883661	2020
41	Awake Sedation With Propofol Attenuates Intraoperative Stress of Carotid Endarterectomy in Regional Anesthesia. ⁶¹	Szabo P...Molnar T	31563659	2020
42	Synchronous versus Staged Carotid Endarterectomy and Coronary Artery Bypass Graft for Patients with Concomitant Severe Coronary and Carotid Artery Stenosis: A Systematic Review and Meta-analysis. ⁶¹	Tzoumas A...Koullias GJ	31629126	2020
43	High-resolution MRI assessed carotid atherosclerotic plaque characteristics comparing men and women with elevated ApoB levels. ⁶¹	Han T...Zhao XQ	32020410	2020
44	Longitudinal tracing of white matter integrity on diffusion tensor imaging in the chronic cerebral ischemia and acute cerebral ischemia. ⁶¹	Liang S...Chen L	31715314	2020
45	What Proportion of Patients Admitted with Stroke or Transient Ischemic Attack May Be Suitable for Newer Cholesterol-Lowering Treatment? ⁶¹	Alakbarzade V...Pereira AC	31732461	2020
46	Transcarotid Artery Revascularization Results in Low Rates of Periprocedural Neurologic Events, Myocardial Infarction, and Death. ⁶¹	Lackey AR...Lal BK	31940109	2020
47	Peak systolic velocity and color aliasing are important in the development of duplex ultrasound criteria for external carotid artery stenosis. ⁶¹	Kronick MD...Moneta GL	31964570	2020
48	Association between Enlarged Perivascular Spaces and Internal Carotid Artery Stenosis: A Study in Patients Diagnosed by Digital Subtraction Angiography. ⁶¹	Shen M...Jiang H	31959503	2020
49	Changes in Carotid Duplex Ultrasound Velocities After Aortic Valve Replacement for Severe Aortic Stenosis. ⁶¹	Shivapour DM...Kim ESH	31267549	2020
50	Predictors and outcomes of stroke after transcatheter aortic valve replacement. ⁶¹	Hatfield SA...Stamou SC	31794084	2020

Sources

Genes for Carotid Stenosis

Genes related to Carotid Stenosis (0 elite genes):

(show all 26)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CDKN2B-AS1	CDKN2B Antisense RNA 1	RNA Gene	153.95	Experimental evidence: Regulation ³⁸ DISEASES inferred ¹⁵	22178423
2	HABP2	Hyaluronan Binding Protein 2	Protein Coding	20.26	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12578864 18605956 14977886 (more) 15486068
3	MMP9	Matrix Metallopeptidase 9	Protein Coding	18.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18166633 17030690 15337875 (more) 17194891 18295103 18984437
4	SELP	Selectin P	Protein Coding	16.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	13130179 17903894 16107361
5	MMP1	Matrix Metallopeptidase 1	Protein Coding	14.99	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18218585 12364729 17268019 (more) 19221176
6	CRP	C-Reactive Protein	Protein Coding	13.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	APOE	Apolipoprotein E	Protein Coding	13.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	LPA	Lipoprotein(A)	Protein Coding	13.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	ACE	Angiotensin I Converting Enzyme	Protein Coding	13.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	12.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	S100B	S100 Calcium Binding Protein B	Protein Coding	12.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	SERPINA12	Serpin Family A Member 12	Protein Coding	12.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	NOS3	Nitric Oxide Synthase 3	Protein Coding	12.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	12.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	12.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	F7	Coagulation Factor VII	Protein Coding	12.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	SELE	Selectin E	Protein Coding	12.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	12.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	TNF	Tumor Necrosis Factor	Protein Coding	12.15	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	SPP1	Secreted Phosphoprotein 1	Protein Coding	12.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	12.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	TFPI	Tissue Factor Pathway Inhibitor	Protein Coding	12.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	REN	Renin	Protein Coding	12.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	11.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
25	MPO	Myeloperoxidase	Protein Coding	11.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
26	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	11.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Carotid Stenosis

ClinVar genetic disease variations for Carotid Stenosis:

⁶ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	RNF213	NM_001256071.3(RNF213):c.11659A>G (p.Lys3887Glu)	SNV	Uncertain significance	523426	rs1555673862	17:78337499-78337499	17:80363699-80363699

Sources

Expression for Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Sources

Pathways for Carotid Stenosis

Pathways related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.64	VCAM1 SPP1 MMP9 MMP1 ICAM1
2	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁴	12.28	VCAM1 SELE NOS3 ICAM1
3	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.13	TNF MTHFR ICAM1 F7 CRP APOE
4	Cell adhesion molecules (CAMs) ³⁶	12.04	VCAM1 SELP SELE ICAM1
5	Spinal Cord Injury ¹	11.92	TNF SELP MMP9 ICAM1
6	Interleukin-4 and 13 signaling ⁶⁵	11.91	VCAM1 TNF MMP9 MMP1 ICAM1
7	TNF signaling pathway ³⁶	11.88	VCAM1 TNF SELE MMP9 ICAM1
8	Fluid shear stress and atherosclerosis ³⁶	11.88	VCAM1 TNF SELE NOS3 MMP9 ICAM1
9	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.77	VCAM1 TNF SELE NOS3 ICAM1
10	Glucocorticoid receptor regulatory network ¹	11.69	SELE MMP1 ICAM1
11	Lung fibrosis ¹	11.55	TNF SPP1 MMP9
12	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.45	TNFRSF11B TNF SPP1 APOE
13	Thromboxane A2 receptor signaling ¹	11.43	VCAM1 SELE NOS3 ICAM1
14	Cell adhesion_Cell-matrix glycoconjugates ²²	11.32	SELE MMP9 MMP1
15	African trypanosomiasis ³⁶	11.27	VCAM1 TNF SELE ICAM1
16	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	11.26	NOS3 MMP9 MMP1
17	Malaria ³⁶	11.25	VCAM1 TNF SELP SELE ICAM1
18	A-beta Pathways: Uptake and Degradation ⁶⁴	11.21	MMP9 APOE ACE
19	amb2 Integrin signaling ¹	11.03	TNF SELP MMP9 LPA ICAM1
20	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	10.9	VCAM1 TNF SELE MMP9 MMP1 ICAM1
21	LDL Oxidation in Atherogenesis ⁶³	10.89	VCAM1 TNF ICAM1

Sources

GO Terms for Carotid Stenosis

Cellular components related to Carotid Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.77	TNFRSF11B TNF SPP1 SERPINA12 S100B MMP9
2	external side of plasma membrane	GO:0009897	9.55	VCAM1 TNF SELP ICAM1 ACE
3	extracellular space	GO:0005615	9.5	VCAM1 TNFRSF11B TNF SPP1 SERPINA12 SELP

Biological processes related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	9.95	MMP9 MMP1 LPA HABP2 F7 ACE
2	inflammatory response	GO:0006954	9.91	TNF SPP1 SELP SELE CRP
3	cell adhesion	GO:0007155	9.91	VCAM1 SPP1 SELP SELE ICAM1 HABP2
4	response to hypoxia	GO:0001666	9.8	VCAM1 MTHFR ICAM1 F7
5	cytokine-mediated signaling pathway	GO:0019221	9.8	VCAM1 TNF MMP9 MMP1 ICAM1
6	leukocyte migration	GO:0050900	9.77	TNF SELP SELE MMP1 ICAM1
7	response to lipopolysaccharide	GO:0032496	9.72	VCAM1 SELP SELE NOS3 ICAM1
8	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO:0007157	9.56	VCAM1 SELP SELE ICAM1
9	negative regulation of lipid storage	GO:0010888	9.54	TNF CRP
10	negative regulation of platelet activation	GO:0010544	9.52	NOS3 APOE
11	membrane to membrane docking	GO:0022614	9.46	VCAM1 ICAM1
12	leukocyte cell-cell adhesion	GO:0007159	9.46	VCAM1 SELP SELE ICAM1
13	leukocyte tethering or rolling	GO:0050901	9.26	VCAM1 TNF SELP SELE
14	extracellular matrix organization	GO:0030198	9.17	VCAM1 TNFRSF11B TNF SPP1 MMP9 MMP1

Molecular functions related to Carotid Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activity	GO:0008233	9.63	MMP9 MMP1 LPA HABP2 F7 ACE
2	sialic acid binding	GO:0033691	9.32	SELP SELE
3	oligosaccharide binding	GO:0070492	9.26	SELP SELE
4	endopeptidase activity	GO:0004175	9.26	MMP9 MMP1 F7 ACE
5	serine-type endopeptidase activity	GO:0004252	9.02	MMP9 MMP1 LPA HABP2 F7

Sources

Sources for Carotid Stenosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia