MCID: CRT013
MIFTS: 50

Carotid Stenosis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Stenosis

MalaCards integrated aliases for Carotid Stenosis:

Name: Carotid Stenosis 12 55 44 15 72
Carotid Artery Stenosis 12 6 15
Stenosis, Carotid Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13001
MeSH 44 D016893
NCIt 50 C95804
SNOMED-CT 68 64586002
UMLS 72 C0007282

Summaries for Carotid Stenosis

MalaCards based summary : Carotid Stenosis, also known as carotid artery stenosis, is related to amaurosis fugax and peripheral vascular disease. An important gene associated with Carotid Stenosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Spinal Cord Injury. The drugs Simvastatin and Desflurane have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

Wikipedia : 75 Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually... more...

Related Diseases for Carotid Stenosis

Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 329)
# Related Disease Score Top Affiliating Genes
1 amaurosis fugax 31.5 MTHFR MMP9
2 peripheral vascular disease 30.5 SELP LPA CRP ACE
3 intermediate coronary syndrome 30.5 SELP CRP ACE
4 coronary stenosis 30.4 CRP APOE ACE
5 aortic aneurysm, familial abdominal, 1 30.3 MMP9 MMP1 CDKN2B-AS1 APOE
6 aortic disease 30.3 MMP9 CRP APOE
7 lipid metabolism disorder 30.2 LPA CRP APOE ACE
8 carotid artery disease 30.2 MMP9 MMP1 LPA CRP APOE ACE
9 aortic valve disease 2 30.0 TNFRSF11B SPP1 CRP ACE
10 proteasome-associated autoinflammatory syndrome 1 29.9 TNF SELP MMP9 CRP
11 intermittent claudication 29.9 SELP CRP ACE
12 generalized atherosclerosis 29.9 SELP CRP APOE ACE
13 coronary artery anomaly 29.9 SELP LPA F7 CRP ACE
14 cerebral atherosclerosis 29.8 MTHFR APOE ACE
15 takayasu arteritis 29.8 TNF MMP9 CRP
16 kawasaki disease 29.7 TNF MMP9 CRP
17 pulmonary disease, chronic obstructive 29.6 TNF MMP9 MMP1 CRP
18 thrombosis 29.6 TFPI SELP MTHFR F7
19 peripheral artery disease 29.6 TNFRSF11B SELP CRP CDKN2B-AS1 ACE
20 end stage renal failure 29.5 TNF CRP ACE
21 atherosclerosis susceptibility 29.2 TNF LPA CRP CDKN2B-AS1 APOE
22 sleep apnea 29.2 TNF S100B CRP APOE ACE
23 hypertension, essential 29.1 SELP LPA CDKN2B-AS1 ACE
24 kidney disease 29.0 TNFRSF11B SPP1 LPA CRP APOE ACE
25 arteries, anomalies of 29.0 TNF SELP MMP9 LPA CRP APOE
26 vascular dementia 28.9 TNF MTHFR APOE ACE
27 arteriosclerosis 28.9 SPP1 SELP MMP9 LPA CRP APOE
28 cerebrovascular disease 28.7 TNF SELP MTHFR MMP9 F7 CRP
29 periodontitis 28.6 TNFRSF11B TNF MMP9 MMP1 CRP CDKN2B-AS1
30 stroke, ischemic 28.5 SELP MTHFR LPA F7 CRP CDKN2B-AS1
31 coronary heart disease 1 28.4 SELP MTHFR LPA CRP CDKN2B-AS1 APOE
32 vascular disease 28.2 TNFRSF11B TNF SELP MTHFR MMP9 LPA
33 diabetes mellitus 28.2 TNF LPA CRP CDKN2B-AS1 ACE
34 heart disease 27.6 TNF SELP S100B MTHFR F7 CRP
35 myocardial infarction 26.2 TNF SELP S100B MTHFR MMP9 LPA
36 moyamoya disease 2 11.6
37 moyamoya disease 5 11.4
38 moyamoya disease 6 with or without achalasia 11.4
39 transient cerebral ischemia 10.8
40 spastic entropion 10.6 MMP9 MMP1
41 chronic actinic dermatitis 10.6 MMP9 MMP1
42 lentigo maligna melanoma 10.6 S100B MMP9
43 periodontitis, chronic 10.6 TNFRSF11B MMP1
44 internal hemorrhoid 10.5 MMP9 MMP1
45 chronic venous insufficiency 10.5 SELP MMP9 MMP1
46 chronic meningitis 10.5 MMP9 CRP
47 moderate and severe traumatic brain injury 10.5 APOE ACE
48 odontogenic myxoma 10.4 S100B MMP9 MMP1
49 chronic enteropathy associated with slco2a1 gene 10.4
50 preterm premature rupture of the membranes 10.4 MMP9 MMP1 CRP

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to Carotid Stenosis

Symptoms & Phenotypes for Carotid Stenosis

GenomeRNAi Phenotypes related to Carotid Stenosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.8 APOE LPA SELP

MGI Mouse Phenotypes related to Carotid Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ACE APOE CRP F7 HABP2 MMP1
2 cardiovascular system MP:0005385 10.18 ACE APOE CRP F7 MMP9 SELP
3 immune system MP:0005387 10.18 ACE APOE CRP HABP2 MMP1 MMP9
4 growth/size/body region MP:0005378 10.16 ACE APOE F7 MMP9 MTHFR SELP
5 integument MP:0010771 9.97 APOE MMP9 MTHFR S100B SELP SPP1
6 mortality/aging MP:0010768 9.9 ACE APOE F7 HABP2 MMP9 MTHFR
7 limbs/digits/tail MP:0005371 9.8 APOE MMP9 MTHFR TFPI TNF TNFRSF11B
8 liver/biliary system MP:0005370 9.8 ACE APOE HABP2 MTHFR SELP SPP1
9 neoplasm MP:0002006 9.43 ACE MMP1 MMP9 SPP1 TNF TREM1
10 skeleton MP:0005390 9.28 APOE F7 MMP9 MTHFR SELP SPP1

Drugs & Therapeutics for Carotid Stenosis

Drugs for Carotid Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 195)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Desflurane Approved Phase 4 57041-67-5 42113
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
7
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
8
Evolocumab Approved Phase 4 1256937-27-5
9
Amlodipine Approved Phase 4 88150-42-9 2162
10
Losartan Approved Phase 4 114798-26-4 3961
11
Atorvastatin Approved Phase 4 134523-00-5 60823
12
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
13
Remifentanil Approved Phase 4 132875-61-7 60815
14
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
15
tannic acid Approved Phase 4 1401-55-4
16
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
17
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
18
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
19
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
20
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
21 Purinergic P2Y Receptor Antagonists Phase 4
22 Purinergic P2 Receptor Antagonists Phase 4
23 Anesthetics, Inhalation Phase 4
24 Trace Elements Phase 4
25 Micronutrients Phase 4
26 Vitamins Phase 4
27 Nutrients Phase 4
28 Vitamin B9 Phase 4
29 Folate Phase 4
30 Vitamin B Complex Phase 4
31 Vitamin B3 Phase 4
32 Nicotinic Acids Phase 4
33 Antioxidants Phase 4
34 insulin Phase 4
35 Insulin, Globin Zinc Phase 4
36 Hypoglycemic Agents Phase 4
37 Protective Agents Phase 4
38 Phosphodiesterase Inhibitors Phase 4
39 Respiratory System Agents Phase 4
40 Neuroprotective Agents Phase 4
41 Anti-Asthmatic Agents Phase 4
42 Phosphodiesterase 3 Inhibitors Phase 4
43 Bronchodilator Agents Phase 4
44 Antibodies Phase 4
45 Antibodies, Monoclonal Phase 4
46 Immunoglobulins Phase 4
47 Immunologic Factors Phase 4
48 Adrenergic Agents Phase 4
49 Neurotransmitter Agents Phase 4
50 Lipid Regulating Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 272)
# Name Status NCT ID Phase Drugs
1 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
2 Comparison of Staged Angioplasty v.s. Routine Single-stage Stenting (CAS) in the Treatment of Patients With Carotid Artery Stenosis at High Risk of Hyperperfusion (STEP): A Randomized Controlled Trial Unknown status NCT02224209 Phase 4
3 Efficacy of Two Different Pre-Intervention Therapeutic Strategies With Clopidogrel and Atorvastatin for the Prevention of Cerebral Damage During Carotid Artery Stenting. Armyda-Caro Randomized Trial. Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
4 A Randomized Evaluation of Short Term and Long Term Outcome After Endovascular Repair by Stenting of Carotid Artery Stenosis in Patients With Severe (70% and Higher) Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
5 Time to Post-Anesthesia Neurological Evaluation and Hemodynamic Stability in Carotid Endarterectomy Comparing Three General Anesthetic Techniques Targeted to a Preset Bispectral Index Value: a Pilot Study Completed NCT03996148 Phase 4 Remifentanil, Propofol, and Desflurane;Remifentanil, Dexmedetomidine, and Desflurane;Remifentanil and Desflurane
6 Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWire™ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System Completed NCT00287508 Phase 4
7 Does the Magnitude of Platelet Inhibition Inversely Correlate With the Number of TCD-detected Microemboli in Asymptomatic Patients Undergoing Carotid Artery Stenting Prior to Cardiac Surgery Who Are Being Pre-treated With 300 mg or 600 mg Loading Dose of Clopidogrel? Completed NCT01146301 Phase 4 Clopidogrel
8 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
9 Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
10 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
11 Comparison the Effect on Cerebral Oxygenation by Sevoflurane-remifentanil or Propofol-remifentanil Anesthesia Using Near-infrared Spectroscopy in Patients Undergoing Carotid Endarterectomy) Completed NCT02609087 Phase 4 Sevoflurane;Propofol
12 The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
13 Efficacy of Two Different Doses of Atorvastatin for Prevention of Periprocedural Ischemic Brain Damage in Chinese Patients Undergoing Carotid Artery Stenting (CAS) Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
14 The Problem of Insulin Resistance in Patients After Carotid Revascularization Recruiting NCT03419767 Phase 4 Melatonin
15 Effect of Cilostazol on In-stent Restenosis After Carotid Artery Stenting; Multi-center, Prospective, Randomized, Open-label Blind-endpoint Trial Active, not recruiting NCT01261234 Phase 4 Cilostazol or Non-Cilostazol
16 Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis Not yet recruiting NCT03931161 Phase 4 Evolocumab Auto-Injector [Repatha];Placebo Auto-Injector
17 Carotid Endarterectomy Versus Optimal Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
18 Phase 4: The Effects of Dexmedetomidine and Remifentanil on Postoperative Hemodynamics and Pain/Opioids in Patients Undergoing Carotid Endarterectomy Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
19 The NexStent® Carotid Stent System: A Post Market Approval Evaluation Study In Conjunction With the FilterWire EZ™ Embolic Protection System Terminated NCT00478673 Phase 4
20 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
21 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting (PROVENON Study) A Randomized Prospective MRI-based Trial. Unknown status NCT01331473 Phase 3
22 Ticlopidine+Ginkgo Biloba Versus Clopidogrel in Clopidogrel Resistant Patients Undergoing Cartoid Artery Stent Placement Unknown status NCT02133989 Phase 3 Ticlopidine + Ginko biloba;Clopidogrel
23 The Embolic Protection With Reverse Flow Study of the GORE Neuro Protection System in Carotid Stenting of Subjects At High Risk for Carotid Endarterectomy Completed NCT00594100 Phase 3
24 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (GORE EMBOLDEN) Completed NCT00766493 Phase 3
25 Randomized, Double-Blind, Multicenter, Trial to Assess the Effect of High & Low Doses of ZD4522 on Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects With Asymptomatic Carotid Stenosis After 24 Months of Dosing. Completed NCT00654394 Phase 3 Rosuvastatin
26 The ViVEXX Carotid Revascularization Trial (VIVA) for High Surgical Risk Patients With Extracranial Carotid Artery Stenosis Using the Bard ViVEXX Carotid Stent and Emboshield BareWire Rapid Exchange Embolic Protection System Completed NCT00417963 Phase 3
27 Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
28 Treatment of Carotid Stenosis With Carotid Stenting and Neurologic Protection With Pre-Procedure and Follow-Up With MRI DIffusion Imaging and Neuropsychological Testing Completed NCT00318851 Phase 3
29 CLEAR-ROAD; a Physician-initiated Carotid Trial Investigating the Efficacy of Endovascular Treatment of Carotid Arterial Disease With the Multi-layer RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
30 Risk Reduction of Symptomatic and Silent Brain Infarctions During Carotid Endarterectomy and Carotid Stenting Due to Ultrasound Activation of Endogenous Fibrinolytic System Using Transcranial Doppler Monitoring Completed NCT01591005 Phase 3
31 Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
32 Randomized Controlled Trial Analyzing the Role of Systematic Preoperative Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3
33 Multicenter, Open-label Study to Evaluate the Safety and Efficacy (by Blinded Reading) of Contrast-Enhanced Magnetic Resonance Angiography (MRA) After a Single Intravenous Injection of 0.1 mmol/kg Gadobutrol in Subjects With Known or Suspected Vascular Disease of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
34 Prospective, Non-Randomized, Multi-Center, Single-Arm Trial to Assess Safety & Efficacy of the Acculink Carotid Stent System With the Accunet Embolic Protection System in High-Risk Patients With Carotid Artery Lesions. Completed NCT00180518 Phase 2, Phase 3
35 Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER) Completed NCT00109382 Phase 2, Phase 3 Aspirin;Clopidogrel;Simvastatin
36 Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes Recruiting NCT02850081 Phase 3 Statin;Atorvastatin
37 99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques Not yet recruiting NCT03630835 Phase 2, Phase 3
38 Abciximab Versus Aspirin for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic >50% Carotid Stenosis: A Pilot Study (ASTERICS) Terminated NCT00126139 Phase 3 Abciximab
39 Protection During Carotid Stenting in High Risk Patients With the TriActiv ProGuard System Terminated NCT00395785 Phase 2, Phase 3
40 Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy. Terminated NCT01415648 Phase 3
41 Randomized, Multicenter, Double-blind, Placebo-controlled, Two-arm Parallel Group Trial of Rimonabant 20-mg od, for Inhibition of Atherosclerosis Progression Assessed by Carotid Artery Intima-media Thickness (CIMT), in Overweight Patients With Additional Risk Factors Terminated NCT00228176 Phase 3 Rimonabant;Placebo (for Rimonabant)
42 The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Asymptomatic and Symptomatic Carotid Artery Stenosis - an Open Proof of Concept Study. Unknown status NCT00904254 Phase 2
43 Phase 2 Study Randomized Placebo Controlled With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis Unknown status NCT01923012 Phase 2 Vitamin K2 (Menaquinone)
44 Tissue Kallikrein Preventing the Restenosis After Stenting of Symptomatic MCA Atherosclerotic Stenosis Unknown status NCT01558245 Phase 2 tissue kallikrein
45 Randomized Controlled Clinical Study on Vulnerable Plaque of Carotid Artery With Chinese Herbal and Insects Medicine Unknown status NCT03072225 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
46 Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Phase II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo Controlled Superiority Study With Parallel Groups Completed NCT01645306 Phase 2 Revacept;Placebo
47 Recurrent Carotid Stenosis Completed NCT00000527 Phase 2 aspirin;dipyridamole
48 Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting Completed NCT01654666 Phase 2
49 A Phase 2 Randomized, Double-blind, Placebo-controlled Study of the Effects of VIA-2291, a 5-Lipoxygenase Inhibitor, on Atherosclerotic Plaque and Biomarkers of Vascular Inflammation in Patients With Carotid Stenosis Undergoing Elective Carotid Endarterectomy Completed NCT00352417 Phase 2 VIA-2291;Placebo
50 A Double Blind Placebo Controlled Study On The Neuroprotective And Anti-Atherogenic Effects Of Palm TocotrienolRich Fraction(Palm Vitamin E) Completed NCT00753532 Phase 2

Search NIH Clinical Center for Carotid Stenosis

Cochrane evidence based reviews: carotid stenosis

Genetic Tests for Carotid Stenosis

Anatomical Context for Carotid Stenosis

MalaCards organs/tissues related to Carotid Stenosis:

41
Brain, Heart, Testes, Endothelial, Bone, Kidney, Neutrophil

Publications for Carotid Stenosis

Articles related to Carotid Stenosis:

(show top 50) (show all 8955)
# Title Authors PMID Year
1
Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. 9 38
19221176 2009
2
Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study. 9 38
18984437 2008
3
Markers of instability in high-risk carotid plaques are reduced by statins. 9 38
18295103 2008
4
Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP. 9 38
18605956 2008
5
High serum level of matrix metalloproteinase-1 and its rapid surge after intervention in patients with significant carotid atherosclerosis. 9 38
18218585 2008
6
Metalloproteinase expression in carotid plaque and its correlation with plasma levels before and after carotid endarterectomy. 9 38
18166633 2007
7
Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis. 9 38
17194891 2007
8
Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1. 9 38
17268019 2007
9
Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis. 9 38
17030690 2006
10
Polymorphisms in the PON gene cluster are associated with Alzheimer disease. 9 38
16319130 2006
11
Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis. 9 38
16107361 2005
12
Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism. 9 38
15486068 2005
13
Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis. 9 38
15337875 2004
14
Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells. 9 38
14977886 2004
15
Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis. 9 38
12578864 2003
16
Serial measurement of surface expressions of CD63, P-selectin and CD40 ligand on platelets in atherosclerotic ischemic stroke. A possible role of CD40 ligand on platelets in atherosclerotic ischemic stroke. 9 38
13130179 2003
17
Thrombocyte activation increases with the degree of carotid artery stenosis. 9 38
17903894 2002
18
Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. 9 38
12364729 2002
19
Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease. 9 38
11388660 2001
20
Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion. 38
31201815 2019
21
Influence of vessel morphology and variations on technical and clinical success in mechanical thrombectomy: -In vivo and in vitro analyses. 38
31254561 2019
22
dl-3-n-butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion. 38
31334611 2019
23
Cardiac surgery in the presence of chronic internal carotid artery occlusion. 38
30904987 2019
24
Cumulative incidence of restenosis in the endovascular treatment of extracranial carotid artery stenosis: a meta-analysis. 38
30705056 2019
25
Association between gender and stoke recurrence in ischemic stroke patients with high-grade carotid artery stenosis. 38
31213380 2019
26
Carotid Artery Stenting Using a Closed-Cell Stent-in-Stent Technique for Unstable Plaque. 38
31074315 2019
27
The relationship between the carotid and coronary artery stenosis: a study based on angiography. 38
31131734 2019
28
Postoperative ischemic events in patients undergoing carotid artery stenting using algorithmic selection for embolic protection. 38
30971186 2019
29
Protective Role of Levetiracetam Against Cognitive Impairment And Brain White Matter Damage in Mouse prolonged Cerebral Hypoperfusion. 38
31302262 2019
30
Carotid artery stenting: an update. 38
31436557 2019
31
Central Retinal Artery Occlusion Associated with Carotid Artery Occlusion. 38
31403098 2019
32
Why randomized controlled trials do not always reflect reality. 38
30878256 2019
33
Novel Application of Transcarotid Artery Stenting With Dynamic Flow Reversal for Treatment of Symptomatic Tandem Carotid Artery Lesions Via an Ascending Aorta to Common Carotid Artery Bypass Graft. 38
31416402 2019
34
Stenting or Surgery for Carotid Stenosis? The Largest Trial in the World Nears Completion. 38
31164270 2019
35
Secular Trends in Procedural Stroke or Death Risks of Stenting Versus Endarterectomy for Symptomatic Carotid Stenosis. 38
31378071 2019
36
Management of Radiation Induced Carotid Stenosis in Head and Neck Cancer. 38
31146165 2019
37
Timing of Carotid Endarterectomy for Symptomatic Carotid Stenosis: A Snapshot of Current Trends and Systematic Review of Literature on Changing Paradigm towards Early Surgery. 38
30799491 2019
38
Carotid Duplex Velocity Criteria Recommended by the Society of Radiologists in Ultrasound and Endorsed by the Intersocietal Accreditation Commission Lacks Predictive Ability for Identifying High Grade Carotid Artery Stenosis. 38
31394249 2019
39
Factors Associated with Hospital Dependent Delay to Carotid Endarterectomy in the Dutch Audit for Carotid Interventions. 38
31395431 2019
40
Non-Contrast-Enhanced Carotid MRA: Clinical Evaluation of a Novel Ungated Radial Quiescent-Interval Slice-Selective MRA at 1.5T. 38
31395666 2019
41
Ischaemic Stroke and the Echocardiographic "Bubble Study": Are We Screening the Right Patients? 38
30131285 2019
42
Evaluating the effectiveness and safety of the carotid Casper-RX stent for tandem lesions in acute ischemic stroke. 38
30514733 2019
43
Carotid artery stenting is safe and effective for symptomatic patients with acute coronary syndrome. 38
31410994 2019
44
IL-33/IL-33R in various types of carotid artery atherosclerotic lesions. 38
31132589 2019
45
Carotid Endarterectomy Outcomes in the Elderly: A Canadian Institutional Experience. 38
30802579 2019
46
Carotid Plaque Positron Emission Tomography Imaging and Cerebral Ischemic Disease. 38
31272325 2019
47
Assessment of long-term survival and stroke after carotid endarterectomy and carotid stenting in patients older than 80 years. 38
30837178 2019
48
The effect of clinical coronary disease severity on outcomes of carotid endarterectomy with and without combined coronary bypass. 38
31401112 2019
49
Efficacy and Safety of Rivaroxaban Versus Aspirin in Embolic Stroke of Undetermined Source and Carotid Atherosclerosis. 38
31401971 2019
50
[TanshinoneⅡA attenuates carotid artery atherosclerosis by deactivating mast cells in adventitia]. 38
31434435 2019

Variations for Carotid Stenosis

ClinVar genetic disease variations for Carotid Stenosis:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 RNF213 NM_001256071.3(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance rs1555673862 17:78337499-78337499 17:80363699-80363699

Expression for Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for Carotid Stenosis

GO Terms for Carotid Stenosis

Cellular components related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNFRSF11B TNF TFPI SPP1 SELP S100B
2 extracellular region GO:0005576 9.47 TREM1 TNFRSF11B TNF TFPI SPP1 S100B
3 extracellular matrix GO:0031012 9.46 TNFRSF11B MMP9 MMP1 APOE

Biological processes related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.67 TNF CDKN2B-AS1 APOE ACE
2 proteolysis GO:0006508 9.63 MMP9 MMP1 LPA HABP2 F7 ACE
3 extracellular matrix organization GO:0030198 9.56 TNFRSF11B TNF SPP1 MMP9
4 regulation of neuronal synaptic plasticity GO:0048168 9.49 S100B APOE
5 leukocyte tethering or rolling GO:0050901 9.48 TNF SELP
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 TNF APOE
7 negative regulation of blood coagulation GO:0030195 9.43 TFPI APOE
8 low-density lipoprotein particle remodeling GO:0034374 9.4 LPA APOE
9 negative regulation of lipid storage GO:0010888 9.32 TNF CRP
10 blood coagulation, extrinsic pathway GO:0007598 8.96 TFPI F7
11 leukocyte migration GO:0050900 8.92 TREM1 TNF SELP MMP1

Molecular functions related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.65 SELP S100B HABP2 F7 CRP
2 peptidase activity GO:0008233 9.63 MMP9 MMP1 LPA HABP2 F7 ACE
3 serine-type endopeptidase activity GO:0004252 9.35 MMP9 MMP1 LPA HABP2 F7
4 tau protein binding GO:0048156 9.32 S100B APOE
5 endopeptidase activity GO:0004175 8.92 MMP9 MMP1 F7 ACE

Sources for Carotid Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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