Carotid Stenosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRT013 MIFTS: 50	Carotid Stenosis Categories: Cardiovascular diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Carotid Stenosis

MalaCards integrated aliases for Carotid Stenosis:

Name: Carotid Stenosis ¹² ⁵⁵ ⁴⁴ ¹⁵ ⁷²

Carotid Artery Stenosis ¹² ⁶ ¹⁵

Stenosis, Carotid Artery ¹²

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13001

MeSH ⁴⁴ D016893

NCIt ⁵⁰ C95804

SNOMED-CT ⁶⁸ 64586002

UMLS ⁷² C0007282

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Summaries for Carotid Stenosis

MalaCards based summary : Carotid Stenosis, also known as carotid artery stenosis, is related to amaurosis fugax and peripheral vascular disease. An important gene associated with Carotid Stenosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Spinal Cord Injury. The drugs Simvastatin and Desflurane have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

Wikipedia : ⁷⁵ Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually... more...

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Related Diseases for Carotid Stenosis

Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 329)

#	Related Disease	Score	Top Affiliating Genes
1	amaurosis fugax	31.5	MTHFR MMP9
2	peripheral vascular disease	30.5	SELP LPA CRP ACE
3	intermediate coronary syndrome	30.5	SELP CRP ACE
4	coronary stenosis	30.4	CRP APOE ACE
5	aortic aneurysm, familial abdominal, 1	30.3	MMP9 MMP1 CDKN2B-AS1 APOE
6	aortic disease	30.3	MMP9 CRP APOE
7	lipid metabolism disorder	30.2	LPA CRP APOE ACE
8	carotid artery disease	30.2	MMP9 MMP1 LPA CRP APOE ACE
9	aortic valve disease 2	30.0	TNFRSF11B SPP1 CRP ACE
10	proteasome-associated autoinflammatory syndrome 1	29.9	TNF SELP MMP9 CRP
11	intermittent claudication	29.9	SELP CRP ACE
12	generalized atherosclerosis	29.9	SELP CRP APOE ACE
13	coronary artery anomaly	29.9	SELP LPA F7 CRP ACE
14	cerebral atherosclerosis	29.8	MTHFR APOE ACE
15	takayasu arteritis	29.8	TNF MMP9 CRP
16	kawasaki disease	29.7	TNF MMP9 CRP
17	pulmonary disease, chronic obstructive	29.6	TNF MMP9 MMP1 CRP
18	thrombosis	29.6	TFPI SELP MTHFR F7
19	peripheral artery disease	29.6	TNFRSF11B SELP CRP CDKN2B-AS1 ACE
20	end stage renal failure	29.5	TNF CRP ACE
21	atherosclerosis susceptibility	29.2	TNF LPA CRP CDKN2B-AS1 APOE
22	sleep apnea	29.2	TNF S100B CRP APOE ACE
23	hypertension, essential	29.1	SELP LPA CDKN2B-AS1 ACE
24	kidney disease	29.0	TNFRSF11B SPP1 LPA CRP APOE ACE
25	arteries, anomalies of	29.0	TNF SELP MMP9 LPA CRP APOE
26	vascular dementia	28.9	TNF MTHFR APOE ACE
27	arteriosclerosis	28.9	SPP1 SELP MMP9 LPA CRP APOE
28	cerebrovascular disease	28.7	TNF SELP MTHFR MMP9 F7 CRP
29	periodontitis	28.6	TNFRSF11B TNF MMP9 MMP1 CRP CDKN2B-AS1
30	stroke, ischemic	28.5	SELP MTHFR LPA F7 CRP CDKN2B-AS1
31	coronary heart disease 1	28.4	SELP MTHFR LPA CRP CDKN2B-AS1 APOE
32	vascular disease	28.2	TNFRSF11B TNF SELP MTHFR MMP9 LPA
33	diabetes mellitus	28.2	TNF LPA CRP CDKN2B-AS1 ACE
34	heart disease	27.6	TNF SELP S100B MTHFR F7 CRP
35	myocardial infarction	26.2	TNF SELP S100B MTHFR MMP9 LPA
36	moyamoya disease 2	11.6
37	moyamoya disease 5	11.4
38	moyamoya disease 6 with or without achalasia	11.4
39	transient cerebral ischemia	10.8
40	spastic entropion	10.6	MMP9 MMP1
41	chronic actinic dermatitis	10.6	MMP9 MMP1
42	lentigo maligna melanoma	10.6	S100B MMP9
43	periodontitis, chronic	10.6	TNFRSF11B MMP1
44	internal hemorrhoid	10.5	MMP9 MMP1
45	chronic venous insufficiency	10.5	SELP MMP9 MMP1
46	chronic meningitis	10.5	MMP9 CRP
47	moderate and severe traumatic brain injury	10.5	APOE ACE
48	odontogenic myxoma	10.4	S100B MMP9 MMP1
49	chronic enteropathy associated with slco2a1 gene	10.4
50	preterm premature rupture of the membranes	10.4	MMP9 MMP1 CRP

Graphical network of the top 20 diseases related to Carotid Stenosis:

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Symptoms & Phenotypes for Carotid Stenosis

GenomeRNAi Phenotypes related to Carotid Stenosis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased free cholesterol	GR00340-A-2	8.8	APOE LPA SELP

MGI Mouse Phenotypes related to Carotid Stenosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.28	ACE APOE CRP F7 HABP2 MMP1
2	cardiovascular system	MP:0005385	10.18	ACE APOE CRP F7 MMP9 SELP
3	immune system	MP:0005387	10.18	ACE APOE CRP HABP2 MMP1 MMP9
4	growth/size/body region	MP:0005378	10.16	ACE APOE F7 MMP9 MTHFR SELP
5	integument	MP:0010771	9.97	APOE MMP9 MTHFR S100B SELP SPP1
6	mortality/aging	MP:0010768	9.9	ACE APOE F7 HABP2 MMP9 MTHFR
7	limbs/digits/tail	MP:0005371	9.8	APOE MMP9 MTHFR TFPI TNF TNFRSF11B
8	liver/biliary system	MP:0005370	9.8	ACE APOE HABP2 MTHFR SELP SPP1
9	neoplasm	MP:0002006	9.43	ACE MMP1 MMP9 SPP1 TNF TREM1
10	skeleton	MP:0005390	9.28	APOE F7 MMP9 MTHFR SELP SPP1

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Drugs & Therapeutics for Carotid Stenosis

Drugs for Carotid Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 195)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Simvastatin

Approved

Phase 4

79902-63-9

54454

Desflurane

Approved

Phase 4

57041-67-5

42113

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Nicotinamide

Approved, Investigational

Phase 4

98-92-0

936

Acetaminophen

Approved

Phase 4

103-90-2

1983

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Cilostazol

Approved, Investigational

Phase 4

73963-72-1

2754

Evolocumab

Approved

Phase 4

1256937-27-5

Amlodipine

Approved

Phase 4

88150-42-9

2162

Losartan

Approved

Phase 4

114798-26-4

3961

Atorvastatin

Approved

Phase 4

134523-00-5

60823

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

68602 5311068

Remifentanil

Approved

Phase 4

132875-61-7

60815

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

tannic acid

Approved

Phase 4

1401-55-4

Benzocaine

Approved, Investigational

Phase 4

94-09-7, 1994-09-7

2337

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 4

59-30-3

6037

Niacin

Approved, Investigational, Nutraceutical

Phase 4

59-67-6

938

Melatonin

Approved, Nutraceutical, Vet_approved

Phase 4

73-31-4

896

Calcium

Approved, Nutraceutical

Phase 4

7440-70-2

271

Purinergic P2Y Receptor Antagonists

Phase 4

Purinergic P2 Receptor Antagonists

Phase 4

Anesthetics, Inhalation

Phase 4

Trace Elements

Phase 4

Micronutrients

Phase 4

Vitamins

Phase 4

Nutrients

Phase 4

Vitamin B9

Phase 4

Folate

Phase 4

Vitamin B Complex

Phase 4

Vitamin B3

Phase 4

Nicotinic Acids

Phase 4

Antioxidants

Phase 4

insulin

Phase 4

Insulin, Globin Zinc

Phase 4

Hypoglycemic Agents

Phase 4

Protective Agents

Phase 4

Phosphodiesterase Inhibitors

Phase 4

Respiratory System Agents

Phase 4

Neuroprotective Agents

Phase 4

Anti-Asthmatic Agents

Phase 4

Phosphodiesterase 3 Inhibitors

Phase 4

Bronchodilator Agents

Phase 4

Antibodies

Phase 4

Antibodies, Monoclonal

Phase 4

Immunoglobulins

Phase 4

Immunologic Factors

Phase 4

Adrenergic Agents

Phase 4

Neurotransmitter Agents

Phase 4

Lipid Regulating Agents

Phase 4

Interventional clinical trials:

(show top 50) (show all 272)

#	Name	Status	NCT ID	Phase	Drugs
1	Early Warning and Optimization Strategy in Carotid Endarterectomy	Unknown status	NCT01210937	Phase 4
2	Comparison of Staged Angioplasty v.s. Routine Single-stage Stenting (CAS) in the Treatment of Patients With Carotid Artery Stenosis at High Risk of Hyperperfusion (STEP）: A Randomized Controlled Trial	Unknown status	NCT02224209	Phase 4
3	Efficacy of Two Different Pre-Intervention Therapeutic Strategies With Clopidogrel and Atorvastatin for the Prevention of Cerebral Damage During Carotid Artery Stenting. Armyda-Caro Randomized Trial.	Unknown status	NCT01572623	Phase 4	Clopidogrel;Atorvastatin
4	A Randomized Evaluation of Short Term and Long Term Outcome After Endovascular Repair by Stenting of Carotid Artery Stenosis in Patients With Severe (70% and Higher) Asymptomatic Carotid Stenosis	Completed	NCT00772278	Phase 4
5	Time to Post-Anesthesia Neurological Evaluation and Hemodynamic Stability in Carotid Endarterectomy Comparing Three General Anesthetic Techniques Targeted to a Preset Bispectral Index Value: a Pilot Study	Completed	NCT03996148	Phase 4	Remifentanil, Propofol, and Desflurane;Remifentanil, Dexmedetomidine, and Desflurane;Remifentanil and Desflurane
6	Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWire™ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System	Completed	NCT00287508	Phase 4
7	Does the Magnitude of Platelet Inhibition Inversely Correlate With the Number of TCD-detected Microemboli in Asymptomatic Patients Undergoing Carotid Artery Stenting Prior to Cardiac Surgery Who Are Being Pre-treated With 300 mg or 600 mg Loading Dose of Clopidogrel?	Completed	NCT01146301	Phase 4	Clopidogrel
8	A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease	Completed	NCT00178672	Phase 4
9	Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology	Completed	NCT00307307	Phase 4	Niacin/simvastatin compared to simvastatin alone at 2 doses
10	Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit	Completed	NCT01948505	Phase 4	Intravenous acetaminophen;Placebo for IV acetaminophen
11	Comparison the Effect on Cerebral Oxygenation by Sevoflurane-remifentanil or Propofol-remifentanil Anesthesia Using Near-infrared Spectroscopy in Patients Undergoing Carotid Endarterectomy)	Completed	NCT02609087	Phase 4	Sevoflurane;Propofol
12	The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy	Completed	NCT03115034	Phase 4	Melatonin;placebo
13	Efficacy of Two Different Doses of Atorvastatin for Prevention of Periprocedural Ischemic Brain Damage in Chinese Patients Undergoing Carotid Artery Stenting (CAS)	Recruiting	NCT03079115	Phase 4	High-dose Atorvastatin;Conventional-dose Atorvastatin
14	The Problem of Insulin Resistance in Patients After Carotid Revascularization	Recruiting	NCT03419767	Phase 4	Melatonin
15	Effect of Cilostazol on In-stent Restenosis After Carotid Artery Stenting; Multi-center, Prospective, Randomized, Open-label Blind-endpoint Trial	Active, not recruiting	NCT01261234	Phase 4	Cilostazol or Non-Cilostazol
16	Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis	Not yet recruiting	NCT03931161	Phase 4	Evolocumab Auto-Injector [Repatha];Placebo Auto-Injector
17	Carotid Endarterectomy Versus Optimal Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis	Terminated	NCT00805311	Phase 4	atorvastatin, aspirin, losartan, amlodipine
18	Phase 4: The Effects of Dexmedetomidine and Remifentanil on Postoperative Hemodynamics and Pain/Opioids in Patients Undergoing Carotid Endarterectomy	Terminated	NCT00335972	Phase 4	Remifentanil;Dexmedetomidine
19	The NexStent® Carotid Stent System: A Post Market Approval Evaluation Study In Conjunction With the FilterWire EZ™ Embolic Protection System	Terminated	NCT00478673	Phase 4
20	Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease	Terminated	NCT01236508	Phase 4
21	PROximal Protection VErsus NON-Protection in Carotid Artery Stenting (PROVENON Study) A Randomized Prospective MRI-based Trial.	Unknown status	NCT01331473	Phase 3
22	Ticlopidine+Ginkgo Biloba Versus Clopidogrel in Clopidogrel Resistant Patients Undergoing Cartoid Artery Stent Placement	Unknown status	NCT02133989	Phase 3	Ticlopidine + Ginko biloba;Clopidogrel
23	The Embolic Protection With Reverse Flow Study of the GORE Neuro Protection System in Carotid Stenting of Subjects At High Risk for Carotid Endarterectomy	Completed	NCT00594100	Phase 3
24	GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (GORE EMBOLDEN)	Completed	NCT00766493	Phase 3
25	Randomized, Double-Blind, Multicenter, Trial to Assess the Effect of High & Low Doses of ZD4522 on Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects With Asymptomatic Carotid Stenosis After 24 Months of Dosing.	Completed	NCT00654394	Phase 3	Rosuvastatin
26	The ViVEXX Carotid Revascularization Trial (VIVA) for High Surgical Risk Patients With Extracranial Carotid Artery Stenosis Using the Bard ViVEXX Carotid Stent and Emboshield BareWire Rapid Exchange Embolic Protection System	Completed	NCT00417963	Phase 3
27	Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis	Completed	NCT00190398	Phase 3
28	Treatment of Carotid Stenosis With Carotid Stenting and Neurologic Protection With Pre-Procedure and Follow-Up With MRI DIffusion Imaging and Neuropsychological Testing	Completed	NCT00318851	Phase 3
29	CLEAR-ROAD; a Physician-initiated Carotid Trial Investigating the Efficacy of Endovascular Treatment of Carotid Arterial Disease With the Multi-layer RoadSaver Stent	Completed	NCT02529345	Phase 2, Phase 3
30	Risk Reduction of Symptomatic and Silent Brain Infarctions During Carotid Endarterectomy and Carotid Stenting Due to Ultrasound Activation of Endogenous Fibrinolytic System Using Transcranial Doppler Monitoring	Completed	NCT01591005	Phase 3
31	Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis	Completed	NCT03333330	Phase 3	Visipaque 320 and SonoVue
32	Randomized Controlled Trial Analyzing the Role of Systematic Preoperative Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease	Completed	NCT02260453	Phase 3
33	Multicenter, Open-label Study to Evaluate the Safety and Efficacy (by Blinded Reading) of Contrast-Enhanced Magnetic Resonance Angiography (MRA) After a Single Intravenous Injection of 0.1 mmol/kg Gadobutrol in Subjects With Known or Suspected Vascular Disease of the Supra-aortic Vessels	Completed	NCT01344447	Phase 3	Gadobutrol (Gadovist, BAY86-4875)
34	Prospective, Non-Randomized, Multi-Center, Single-Arm Trial to Assess Safety & Efficacy of the Acculink Carotid Stent System With the Accunet Embolic Protection System in High-Risk Patients With Carotid Artery Lesions.	Completed	NCT00180518	Phase 2, Phase 3
35	Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER)	Completed	NCT00109382	Phase 2, Phase 3	Aspirin;Clopidogrel;Simvastatin
36	Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes	Recruiting	NCT02850081	Phase 3	Statin;Atorvastatin
37	99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques	Not yet recruiting	NCT03630835	Phase 2, Phase 3
38	Abciximab Versus Aspirin for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic >50% Carotid Stenosis: A Pilot Study (ASTERICS)	Terminated	NCT00126139	Phase 3	Abciximab
39	Protection During Carotid Stenting in High Risk Patients With the TriActiv ProGuard System	Terminated	NCT00395785	Phase 2, Phase 3
40	Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy.	Terminated	NCT01415648	Phase 3
41	Randomized, Multicenter, Double-blind, Placebo-controlled, Two-arm Parallel Group Trial of Rimonabant 20-mg od, for Inhibition of Atherosclerosis Progression Assessed by Carotid Artery Intima-media Thickness (CIMT), in Overweight Patients With Additional Risk Factors	Terminated	NCT00228176	Phase 3	Rimonabant;Placebo (for Rimonabant)
42	The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Asymptomatic and Symptomatic Carotid Artery Stenosis - an Open Proof of Concept Study.	Unknown status	NCT00904254	Phase 2
43	Phase 2 Study Randomized Placebo Controlled With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis	Unknown status	NCT01923012	Phase 2	Vitamin K2 (Menaquinone)
44	Tissue Kallikrein Preventing the Restenosis After Stenting of Symptomatic MCA Atherosclerotic Stenosis	Unknown status	NCT01558245	Phase 2	tissue kallikrein
45	Randomized Controlled Clinical Study on Vulnerable Plaque of Carotid Artery With Chinese Herbal and Insects Medicine	Unknown status	NCT03072225	Phase 2	Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
46	Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Phase II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo Controlled Superiority Study With Parallel Groups	Completed	NCT01645306	Phase 2	Revacept;Placebo
47	Recurrent Carotid Stenosis	Completed	NCT00000527	Phase 2	aspirin;dipyridamole
48	Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting	Completed	NCT01654666	Phase 2
49	A Phase 2 Randomized, Double-blind, Placebo-controlled Study of the Effects of VIA-2291, a 5-Lipoxygenase Inhibitor, on Atherosclerotic Plaque and Biomarkers of Vascular Inflammation in Patients With Carotid Stenosis Undergoing Elective Carotid Endarterectomy	Completed	NCT00352417	Phase 2	VIA-2291;Placebo
50	A Double Blind Placebo Controlled Study On The Neuroprotective And Anti-Atherogenic Effects Of Palm TocotrienolRich Fraction(Palm Vitamin E)	Completed	NCT00753532	Phase 2

Search NIH Clinical Center for Carotid Stenosis

Cochrane evidence based reviews: carotid stenosis

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Genetic Tests for Carotid Stenosis

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Anatomical Context for Carotid Stenosis

MalaCards organs/tissues related to Carotid Stenosis:

⁴¹

Brain, Heart, Testes, Endothelial, Bone, Kidney, Neutrophil

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Publications for Carotid Stenosis

Articles related to Carotid Stenosis:

(show top 50) (show all 8955)

#	Title	Authors	PMID	Year
1	Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. ⁹ ³⁸	Cozzolino M...Gallieni M	19221176	2009
2	Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study. ⁹ ³⁸	Romero JR...Seshadri S	18984437	2008
3	Markers of instability in high-risk carotid plaques are reduced by statins. ⁹ ³⁸	Kunte H...Harms L	18295103	2008
4	Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP. ⁹ ³⁸	Stephan S...Vitzthum F	18605956	2008
5	High serum level of matrix metalloproteinase-1 and its rapid surge after intervention in patients with significant carotid atherosclerosis. ⁹ ³⁸	Wu YW...Kao HL	18218585	2008
6	Metalloproteinase expression in carotid plaque and its correlation with plasma levels before and after carotid endarterectomy. ⁹ ³⁸	Taurino M...Faraglia V	18166633	2007
7	Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis. ⁹ ³⁸	Zalba G...Diez J	17194891	2007
8	Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1. ⁹ ³⁸	Wu YW...Yang WS	17268019	2007
9	Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis. ⁹ ³⁸	Eldrup N...Nordestgaard BG	17030690	2006
10	Polymorphisms in the PON gene cluster are associated with Alzheimer disease. ⁹ ³⁸	Erlich PM...MIRAGE Study Group	16319130	2006
11	Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis. ⁹ ³⁸	McCabe DJ...Brown MM	16107361	2005
12	Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism. ⁹ ³⁸	Hoppe B...Salama A	15486068	2005
13	Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis. ⁹ ³⁸	Alvarez B...Matas M	15337875	2004
14	Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells. ⁹ ³⁸	Kannemeier C...Kanse SM	14977886	2004
15	Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis. ⁹ ³⁸	Willeit J...Roemisch J	12578864	2003
16	Serial measurement of surface expressions of CD63, P-selectin and CD40 ligand on platelets in atherosclerotic ischemic stroke. A possible role of CD40 ligand on platelets in atherosclerotic ischemic stroke. ⁹ ³⁸	Cha JK...Kim JW	13130179	2003
17	Thrombocyte activation increases with the degree of carotid artery stenosis. ⁹ ³⁸	Stolz E...Kaps M	17903894	2002
18	Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. ⁹ ³⁸	Ghilardi G...Scorza R	12364729	2002
19	Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease. ⁹ ³⁸	Topic E...Zuntar I	11388660	2001
20	Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion. ³⁸	Yasuda K...Takahashi R	31201815	2019
21	Influence of vessel morphology and variations on technical and clinical success in mechanical thrombectomy: -In vivo and in vitro analyses. ³⁸	Hopf-Jensen S...Muller-Hulsbeck S	31254561	2019
22	dl-3-n-butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion. ³⁸	Han QY...Han LJ	31334611	2019
23	Cardiac surgery in the presence of chronic internal carotid artery occlusion. ³⁸	Lescan M...Schlensak C	30904987	2019
24	Cumulative incidence of restenosis in the endovascular treatment of extracranial carotid artery stenosis: a meta-analysis. ³⁸	Clavel P...Marin B	30705056	2019
25	Association between gender and stoke recurrence in ischemic stroke patients with high-grade carotid artery stenosis. ³⁸	Chen CY...Huang WY	31213380	2019
26	Carotid Artery Stenting Using a Closed-Cell Stent-in-Stent Technique for Unstable Plaque. ³⁸	Myouchin K...Kichikawa K	31074315	2019
27	The relationship between the carotid and coronary artery stenosis: a study based on angiography. ³⁸	Wang L...He X	31131734	2019
28	Postoperative ischemic events in patients undergoing carotid artery stenting using algorithmic selection for embolic protection. ³⁸	Kawabata Y...Tsukahara T	30971186	2019
29	Protective Role of Levetiracetam Against Cognitive Impairment And Brain White Matter Damage in Mouse prolonged Cerebral Hypoperfusion. ³⁸	Inaba T...Urabe T	31302262	2019
30	Carotid artery stenting: an update. ³⁸	Spiliopoulos S...Brountzos E	31436557	2019
31	Central Retinal Artery Occlusion Associated with Carotid Artery Occlusion. ³⁸	Weymouth W...Pedersen C	31403098	2019
32	Why randomized controlled trials do not always reflect reality. ³⁸	Paraskevas KI...Veith FJ	30878256	2019
33	Novel Application of Transcarotid Artery Stenting With Dynamic Flow Reversal for Treatment of Symptomatic Tandem Carotid Artery Lesions Via an Ascending Aorta to Common Carotid Artery Bypass Graft. ³⁸	Donde NN...Motaganahalli RL	31416402	2019
34	Stenting or Surgery for Carotid Stenosis? The Largest Trial in the World Nears Completion. ³⁸	Halliday A...Bulbulia R	31164270	2019
35	Secular Trends in Procedural Stroke or Death Risks of Stenting Versus Endarterectomy for Symptomatic Carotid Stenosis. ³⁸	Muller MD...Bonati LH	31378071	2019
36	Management of Radiation Induced Carotid Stenosis in Head and Neck Cancer. ³⁸	Trojanowski P...Jargiello T	31146165	2019
37	Timing of Carotid Endarterectomy for Symptomatic Carotid Stenosis: A Snapshot of Current Trends and Systematic Review of Literature on Changing Paradigm towards Early Surgery. ³⁸	Savardekar AR...Sun H	30799491	2019
38	Carotid Duplex Velocity Criteria Recommended by the Society of Radiologists in Ultrasound and Endorsed by the Intersocietal Accreditation Commission Lacks Predictive Ability for Identifying High Grade Carotid Artery Stenosis. ³⁸	Arous EJ...Schanzer A	31394249	2019
39	Factors Associated with Hospital Dependent Delay to Carotid Endarterectomy in the Dutch Audit for Carotid Interventions. ³⁸	Kuhrij LS...de Borst GJ	31395431	2019
40	Non-Contrast-Enhanced Carotid MRA: Clinical Evaluation of a Novel Ungated Radial Quiescent-Interval Slice-Selective MRA at 1.5T. ³⁸	Peters S...Salehi Ravesh M	31395666	2019
41	Ischaemic Stroke and the Echocardiographic "Bubble Study": Are We Screening the Right Patients? ³⁸	Maggiore P...McQuillan B	30131285	2019
42	Evaluating the effectiveness and safety of the carotid Casper-RX stent for tandem lesions in acute ischemic stroke. ³⁸	Bartolini B...Saliou G	30514733	2019
43	Carotid artery stenting is safe and effective for symptomatic patients with acute coronary syndrome. ³⁸	Casana R...Parati G	31410994	2019
44	IL-33/IL-33R in various types of carotid artery atherosclerotic lesions. ³⁸	Stankovic M...Lukic ML	31132589	2019
45	Carotid Endarterectomy Outcomes in the Elderly: A Canadian Institutional Experience. ³⁸	Doonan RJ...Gill HL	30802579	2019
46	Carotid Plaque Positron Emission Tomography Imaging and Cerebral Ischemic Disease. ³⁸	Chaker S...Gupta A	31272325	2019
47	Assessment of long-term survival and stroke after carotid endarterectomy and carotid stenting in patients older than 80 years. ³⁸	Mazzaccaro D...Nano G	30837178	2019
48	The effect of clinical coronary disease severity on outcomes of carotid endarterectomy with and without combined coronary bypass. ³⁸	Wang LJ...Clouse WD	31401112	2019
49	Efficacy and Safety of Rivaroxaban Versus Aspirin in Embolic Stroke of Undetermined Source and Carotid Atherosclerosis. ³⁸	Ntaios G...NAVIGATE ESUS Investigators	31401971	2019
50	[TanshinoneⅡA attenuates carotid artery atherosclerosis by deactivating mast cells in adventitia]. ³⁸	Sun WL...Gao YX	31434435	2019

Sources

Genes for Carotid Stenosis

Genes related to Carotid Stenosis (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CDKN2B-AS1	CDKN2B Antisense RNA 1	RNA Gene	150	Experimental evidence: Regulation ³⁹	22178423
2	HABP2	Hyaluronan Binding Protein 2	Protein Coding	29.95	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12578864 18605956 14977886 (more) 15486068
3	MMP9	Matrix Metallopeptidase 9	Protein Coding	27.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	18166633 17030690 15337875 (more) 17194891 18295103 18984437
4	SELP	Selectin P	Protein Coding	25.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	13130179 17903894 16107361
5	MMP1	Matrix Metallopeptidase 1	Protein Coding	24.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	18218585 12364729 17268019 (more) 19221176
6	CRP	C-Reactive Protein	Protein Coding	22.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	S100B	S100 Calcium Binding Protein B	Protein Coding	22.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	LPA	Lipoprotein(A)	Protein Coding	22.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	21.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	F7	Coagulation Factor VII	Protein Coding	21.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	SPP1	Secreted Phosphoprotein 1	Protein Coding	21.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	APOE	Apolipoprotein E	Protein Coding	21.17	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	TFPI	Tissue Factor Pathway Inhibitor	Protein Coding	20.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	ACE	Angiotensin I Converting Enzyme	Protein Coding	20.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	TNF	Tumor Necrosis Factor	Protein Coding	20.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	20.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Carotid Stenosis

ClinVar genetic disease variations for Carotid Stenosis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	GRCh37 Pos	GRCh38 Pos
1	RNF213	NM_001256071.3(RNF213): c.11659A> G (p.Lys3887Glu)	single nucleotide variant	Uncertain significance	rs1555673862	17:78337499-78337499	17:80363699-80363699

Sources

Expression for Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Sources

Pathways for Carotid Stenosis

Pathways related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.89	TNF MTHFR F7 CRP APOE
2	Spinal Cord Injury ¹	11.75	TNF SELP MMP9
3	Interleukin-4 and 13 signaling ⁶⁶	11.69	TNF MMP9 MMP1
4	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.58	TNF MMP9 MMP1
5	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.34	TNF MMP9 MMP1
6	Lung fibrosis ¹	11.3	TNF SPP1 MMP9
7	A-beta Pathways: Uptake and Degradation ⁶⁵	10.94	MMP9 APOE ACE
8	amb2 Integrin signaling ¹	10.94	TNF SELP MMP9 LPA
9	Overview of nanoparticle effects ¹	10.79	TNF CRP
10	Syndecan-1-mediated signaling events ¹	10.71	MMP9 MMP1
11	Osteoclast Signaling ¹	10.64	TNFRSF11B SPP1
12	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.58	TNFRSF11B TNF SPP1 APOE

Sources

GO Terms for Carotid Stenosis

Cellular components related to Carotid Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.73	TNFRSF11B TNF TFPI SPP1 SELP S100B
2	extracellular region	GO:0005576	9.47	TREM1 TNFRSF11B TNF TFPI SPP1 S100B
3	extracellular matrix	GO:0031012	9.46	TNFRSF11B MMP9 MMP1 APOE

Biological processes related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	9.67	TNF CDKN2B-AS1 APOE ACE
2	proteolysis	GO:0006508	9.63	MMP9 MMP1 LPA HABP2 F7 ACE
3	extracellular matrix organization	GO:0030198	9.56	TNFRSF11B TNF SPP1 MMP9
4	regulation of neuronal synaptic plasticity	GO:0048168	9.49	S100B APOE
5	leukocyte tethering or rolling	GO:0050901	9.48	TNF SELP
6	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.46	TNF APOE
7	negative regulation of blood coagulation	GO:0030195	9.43	TFPI APOE
8	low-density lipoprotein particle remodeling	GO:0034374	9.4	LPA APOE
9	negative regulation of lipid storage	GO:0010888	9.32	TNF CRP
10	blood coagulation, extrinsic pathway	GO:0007598	8.96	TFPI F7
11	leukocyte migration	GO:0050900	8.92	TREM1 TNF SELP MMP1

Molecular functions related to Carotid Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium ion binding	GO:0005509	9.65	SELP S100B HABP2 F7 CRP
2	peptidase activity	GO:0008233	9.63	MMP9 MMP1 LPA HABP2 F7 ACE
3	serine-type endopeptidase activity	GO:0004252	9.35	MMP9 MMP1 LPA HABP2 F7
4	tau protein binding	GO:0048156	9.32	S100B APOE
5	endopeptidase activity	GO:0004175	8.92	MMP9 MMP1 F7 ACE

Sources

Sources for Carotid Stenosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia