MCID: CRT013
MIFTS: 50

Carotid Stenosis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Carotid Stenosis

MalaCards integrated aliases for Carotid Stenosis:

Name: Carotid Stenosis 12 54 43 15 71
Carotid Artery Stenosis 12 6 15
Stenosis, Carotid Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13001
MeSH 43 D016893
NCIt 49 C95804
SNOMED-CT 67 64586002
UMLS 71 C0007282

Summaries for Carotid Stenosis

MalaCards based summary : Carotid Stenosis, also known as carotid artery stenosis, is related to amaurosis fugax and intracranial embolism. An important gene associated with Carotid Stenosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Development VEGF signaling via VEGFR2 - generic cascades. The drugs Simvastatin and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 74 Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually... more...

Related Diseases for Carotid Stenosis

Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 521)
# Related Disease Score Top Affiliating Genes
1 amaurosis fugax 31.5 MTHFR MMP9
2 intracranial embolism 30.9 SELP CRP ACE
3 hypercholesterolemia, familial, 1 30.9 NOS3 LPA CRP APOE ACE
4 carotid artery disease 30.8 SELP SELE MMP9 MMP1 LPA CRP
5 chlamydia pneumonia 30.7 TNF CRP APOE
6 coronary stenosis 30.7 ICAM1 CRP APOE ACE
7 lipid metabolism disorder 30.7 SELE LPA CRP APOE ACE
8 intermediate coronary syndrome 30.6 VCAM1 SELP LPA CRP ACE
9 mitral valve stenosis 30.6 SELP CRP ACE
10 atrial fibrillation 30.6 SELP NOS3 CRP ACE
11 silent myocardial infarction 30.6 LPA CRP ACE
12 central sleep apnea 30.6 NOS3 CRP ACE
13 retinal artery occlusion 30.5 MTHFR ICAM1 CRP ACE
14 cholesterol embolism 30.5 F7 CRP ACE
15 arteriosclerosis obliterans 30.5 VCAM1 SELP ICAM1
16 arteriovenous malformation 30.5 TNF MMP9 APOE
17 aortic aneurysm 30.5 MMP9 CRP CDKN2B-AS1 APOE ACE
18 generalized atherosclerosis 30.5 LPA CRP APOE ACE
19 aortic valve disease 2 30.5 TNFRSF11B SPP1 LPA CRP ACE
20 retinal vein occlusion 30.5 TNF MTHFR ACE
21 tolosa-hunt syndrome 30.4 CRP ACE
22 cholesteatoma of middle ear 30.4 TNFRSF11B MMP9 MMP1 ICAM1
23 moyamoya disease 1 30.4 MTHFR MMP9 LPA
24 angina pectoris 30.4 NOS3 LPA CRP ACE
25 familial hyperlipidemia 30.4 LPA CRP APOE ACE
26 mitral valve disease 30.4 NOS3 MMP1 CRP ACE
27 intermittent claudication 30.4 SELP CRP ACE
28 neuroretinitis 30.3 CRP ACE
29 intracranial aneurysm 30.3 TNF NOS3 CDKN2B-AS1 APOE ACE
30 hepatic encephalopathy 30.3 TNF S100B MMP9
31 allergic hypersensitivity disease 30.3 VCAM1 TNF SELE ICAM1
32 microvascular complications of diabetes 5 30.3 VCAM1 NOS3 ICAM1 ACE
33 nonarteritic anterior ischemic optic neuropathy 30.3 NOS3 MTHFR CRP ACE
34 aortic disease 30.2 MMP9 CRP APOE ACE
35 end stage renal disease 30.2 TNF NOS3 CRP ACE
36 arteries, anomalies of 30.2 VCAM1 TNF NOS3 LPA ICAM1 CRP
37 peripheral vascular disease 30.2 VCAM1 SELP SELE NOS3 MTHFR LPA
38 colorectal adenoma 30.2 TNF MTHFR MMP9 CRP
39 pulmonary disease, chronic obstructive 30.2 TNF MMP9 MMP1 CRP ACE
40 migraine without aura 30.2 TNF S100B MTHFR
41 microvascular complications of diabetes 1 30.2 VCAM1 MMP9 ICAM1
42 systolic heart failure 30.1 TNF NOS3 MMP9 CRP ACE
43 homocysteinemia 30.1 VCAM1 NOS3 MTHFR LPA CRP APOE
44 tetralogy of fallot 30.1 MTHFR MMP9 CRP APOE ACE
45 kawasaki disease 30.1 TNF SELE MMP9 CRP
46 retinal vascular occlusion 30.0 SELP MTHFR LPA ICAM1 CRP
47 deficiency anemia 30.0 TNF SELP CRP ACE
48 patent foramen ovale 30.0 MTHFR LPA CRP ACE
49 aortic aneurysm, familial abdominal, 1 30.0 TNFRSF11B MMP9 MMP1 CRP CDKN2B-AS1 APOE
50 vasculitis 30.0 VCAM1 TNF SELP SELE ICAM1 CRP

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to Carotid Stenosis

Symptoms & Phenotypes for Carotid Stenosis

MGI Mouse Phenotypes related to Carotid Stenosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 ACE APOE CRP F7 HABP2 ICAM1
2 growth/size/body region MP:0005378 10.28 ACE APOE F7 ICAM1 MMP9 MTHFR
3 cardiovascular system MP:0005385 10.27 ACE APOE CRP F7 ICAM1 MMP9
4 immune system MP:0005387 10.17 ACE APOE CRP HABP2 ICAM1 MMP1
5 hematopoietic system MP:0005397 10.14 ACE APOE ICAM1 MMP9 NOS3 SELE
6 integument MP:0010771 9.91 APOE ICAM1 MMP9 MTHFR S100B SELE
7 liver/biliary system MP:0005370 9.85 ACE APOE HABP2 MTHFR NOS3 SELE
8 mortality/aging MP:0010768 9.8 ACE APOE F7 HABP2 ICAM1 MMP9
9 vision/eye MP:0005391 9.28 APOE ICAM1 MMP9 MTHFR NOS3 SELE

Drugs & Therapeutics for Carotid Stenosis

Drugs for Carotid Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 179)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
3
Desflurane Approved Phase 4 57041-67-5 42113
4
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
7
Evolocumab Approved Phase 4 1256937-27-5
8
Amlodipine Approved Phase 4 88150-42-9 2162
9
Losartan Approved Phase 4 114798-26-4 3961
10
Atorvastatin Approved Phase 4 134523-00-5 60823
11
Remifentanil Approved Phase 4 132875-61-7 60815
12
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
13
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
14
tannic acid Approved Phase 4 1401-55-4
15
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
17
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
18
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
19 Protective Agents Phase 4
20 Anesthetics, General Phase 4
21 Anesthetics, Intravenous Phase 4
22 Anesthetics, Inhalation Phase 4
23 Antioxidants Phase 4
24 Vitamin B Complex Phase 4
25 Nicotinic Acids Phase 4
26 Vitamin B3 Phase 4
27 Folate Phase 4
28 Vitamin B9 Phase 4
29 Adrenergic Agents Phase 4
30 Neurotransmitter Agents Phase 4
31 Lipid Regulating Agents Phase 4
32 Hypolipidemic Agents Phase 4
33 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
34 Anticholesteremic Agents Phase 4
35 Calcium, Dietary Phase 4
36 Antimetabolites Phase 4
37 Hormones Phase 4
38 Anti-Arrhythmia Agents Phase 4
39 Vasodilator Agents Phase 4
40 calcium channel blockers Phase 4
41 Fluorodeoxyglucose F18 Phase 4
42 Adrenergic alpha-Agonists Phase 4
43 Narcotics Phase 4
44 Hypnotics and Sedatives Phase 4
45 Adrenergic Agonists Phase 4
46 Analgesics, Opioid Phase 4
47 Radiopharmaceuticals Phase 4
48
Calcium Nutraceutical Phase 4 7440-70-2 271
49
Ticlopidine Approved Phase 3 55142-85-3 5472
50
Clopidogrel Approved Phase 2, Phase 3 113665-84-2, 120202-66-6 60606

Interventional clinical trials:

(show top 50) (show all 297)
# Name Status NCT ID Phase Drugs
1 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
2 Comparison of Staged Angioplasty v.s. Routine Single-stage Stenting (CAS) in the Treatment of Patients With Carotid Artery Stenosis at High Risk of Hyperperfusion (STEP): A Randomized Controlled Trial Unknown status NCT02224209 Phase 4
3 Efficacy of Two Different Pre-Intervention Therapeutic Strategies With Clopidogrel and Atorvastatin for the Prevention of Cerebral Damage During Carotid Artery Stenting. Armyda-Caro Randomized Trial. Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
4 The Problem of Insulin Resistance in Patients After Carotid Revascularization Unknown status NCT03419767 Phase 4 Melatonin
5 A Randomized Evaluation of Short Term and Long Term Outcome After Endovascular Repair by Stenting of Carotid Artery Stenosis in Patients With Severe (70% and Higher) Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
6 Time to Post-Anesthesia Neurological Evaluation and Hemodynamic Stability in Carotid Endarterectomy Comparing Three General Anesthetic Techniques Targeted to a Preset Bispectral Index Value: a Pilot Study Completed NCT03996148 Phase 4 Remifentanil, Propofol, and Desflurane;Remifentanil, Dexmedetomidine, and Desflurane;Remifentanil and Desflurane
7 Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWire™ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System Completed NCT00287508 Phase 4
8 Does the Magnitude of Platelet Inhibition Inversely Correlate With the Number of TCD-detected Microemboli in Asymptomatic Patients Undergoing Carotid Artery Stenting Prior to Cardiac Surgery Who Are Being Pre-treated With 300 mg or 600 mg Loading Dose of Clopidogrel? Completed NCT01146301 Phase 4 Clopidogrel
9 A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
10 Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
11 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
12 Comparison the Effect on Cerebral Oxygenation by Sevoflurane-remifentanil or Propofol-remifentanil Anesthesia Using Near-infrared Spectroscopy in Patients Undergoing Carotid Endarterectomy) Completed NCT02609087 Phase 4 Sevoflurane;Propofol
13 The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
14 Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis Recruiting NCT03931161 Phase 4 Evolocumab Auto-Injector [Repatha];Placebo Auto-Injector
15 Efficacy of Two Different Doses of Atorvastatin for Prevention of Periprocedural Ischemic Brain Damage in Chinese Patients Undergoing Carotid Artery Stenting (CAS) Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
16 Carotid Endarterectomy Versus Optimal Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
17 Phase 4: The Effects of Dexmedetomidine and Remifentanil on Postoperative Hemodynamics and Pain/Opioids in Patients Undergoing Carotid Endarterectomy Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
18 The NexStent® Carotid Stent System: A Post Market Approval Evaluation Study In Conjunction With the FilterWire EZ™ Embolic Protection System Terminated NCT00478673 Phase 4
19 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
20 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting (PROVENON Study) A Randomized Prospective MRI-based Trial. Unknown status NCT01331473 Phase 3
21 Ticlopidine+Ginkgo Biloba Versus Clopidogrel in Clopidogrel Resistant Patients Undergoing Cartoid Artery Stent Placement Unknown status NCT02133989 Phase 3 Ticlopidine + Ginko biloba;Clopidogrel
22 The Embolic Protection With Reverse Flow Study of the GORE Neuro Protection System in Carotid Stenting of Subjects At High Risk for Carotid Endarterectomy Completed NCT00594100 Phase 3
23 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (GORE EMBOLDEN) Completed NCT00766493 Phase 3
24 Randomized, Double-Blind, Multicenter, Trial to Assess the Effect of High & Low Doses of ZD4522 on Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects With Asymptomatic Carotid Stenosis After 24 Months of Dosing. Completed NCT00654394 Phase 3 Rosuvastatin
25 The ViVEXX Carotid Revascularization Trial (VIVA) for High Surgical Risk Patients With Extracranial Carotid Artery Stenosis Using the Bard ViVEXX Carotid Stent and Emboshield BareWire Rapid Exchange Embolic Protection System Completed NCT00417963 Phase 3
26 Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
27 Treatment of Carotid Stenosis With Carotid Stenting and Neurologic Protection With Pre-Procedure and Follow-Up With MRI DIffusion Imaging and Neuropsychological Testing Completed NCT00318851 Phase 3
28 CLEAR-ROAD; a Physician-initiated Carotid Trial Investigating the Efficacy of Endovascular Treatment of Carotid Arterial Disease With the Multi-layer RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
29 Risk Reduction of Symptomatic and Silent Brain Infarctions During Carotid Endarterectomy and Carotid Stenting Due to Ultrasound Activation of Endogenous Fibrinolytic System Using Transcranial Doppler Monitoring Completed NCT01591005 Phase 3
30 Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
31 Randomized Controlled Trial Analyzing the Role of Systematic Preoperative Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3
32 Multicenter, Open-label Study to Evaluate the Safety and Efficacy (by Blinded Reading) of Contrast-Enhanced Magnetic Resonance Angiography (MRA) After a Single Intravenous Injection of 0.1 mmol/kg Gadobutrol in Subjects With Known or Suspected Vascular Disease of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
33 Prospective, Non-Randomized, Multi-Center, Single-Arm Trial to Assess Safety & Efficacy of the Acculink Carotid Stent System With the Accunet Embolic Protection System in High-Risk Patients With Carotid Artery Lesions. Completed NCT00180518 Phase 2, Phase 3
34 Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER) Completed NCT00109382 Phase 2, Phase 3 Aspirin;Clopidogrel;Simvastatin
35 Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes Recruiting NCT02850081 Phase 3 Statin;Atorvastatin
36 99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques Not yet recruiting NCT03630835 Phase 2, Phase 3
37 Protection During Carotid Stenting in High Risk Patients With the TriActiv ProGuard System Terminated NCT00395785 Phase 2, Phase 3
38 Abciximab Versus Aspirin for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic >50% Carotid Stenosis: A Pilot Study (ASTERICS) Terminated NCT00126139 Phase 3 Abciximab
39 Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy. Terminated NCT01415648 Phase 3
40 Randomized, Multicenter, Double-blind, Placebo-controlled, Two-arm Parallel Group Trial of Rimonabant 20-mg od, for Inhibition of Atherosclerosis Progression Assessed by Carotid Artery Intima-media Thickness (CIMT), in Overweight Patients With Additional Risk Factors Terminated NCT00228176 Phase 3 Rimonabant;Placebo (for Rimonabant)
41 The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Asymptomatic and Symptomatic Carotid Artery Stenosis - an Open Proof of Concept Study. Unknown status NCT00904254 Phase 2
42 Phase 2 Study Randomized Placebo Controlled With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis Unknown status NCT01923012 Phase 2 Vitamin K2 (Menaquinone)
43 Tissue Kallikrein Preventing the Restenosis After Stenting of Symptomatic MCA Atherosclerotic Stenosis Unknown status NCT01558245 Phase 2 tissue kallikrein
44 Randomized Controlled Clinical Study on Vulnerable Plaque of Carotid Artery With Chinese Herbal and Insects Medicine Unknown status NCT03072225 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
45 Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Phase II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo Controlled Superiority Study With Parallel Groups Completed NCT01645306 Phase 2 Revacept;Placebo
46 Recurrent Carotid Stenosis Completed NCT00000527 Phase 2 aspirin;dipyridamole
47 Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting Completed NCT01654666 Phase 2
48 A Phase 2 Randomized, Double-blind, Placebo-controlled Study of the Effects of VIA-2291, a 5-Lipoxygenase Inhibitor, on Atherosclerotic Plaque and Biomarkers of Vascular Inflammation in Patients With Carotid Stenosis Undergoing Elective Carotid Endarterectomy Completed NCT00352417 Phase 2 VIA-2291;Placebo
49 A Double Blind Placebo Controlled Study On The Neuroprotective And Anti-Atherogenic Effects Of Palm TocotrienolRich Fraction(Palm Vitamin E) Completed NCT00753532 Phase 2
50 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin

Search NIH Clinical Center for Carotid Stenosis

Cochrane evidence based reviews: carotid stenosis

Genetic Tests for Carotid Stenosis

Anatomical Context for Carotid Stenosis

MalaCards organs/tissues related to Carotid Stenosis:

40
Brain, Heart, Testes, Endothelial, Bone, Kidney, Neutrophil

Publications for Carotid Stenosis

Articles related to Carotid Stenosis:

(show top 50) (show all 9343)
# Title Authors PMID Year
1
Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. 54 61
19221176 2009
2
Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study. 54 61
18984437 2008
3
Markers of instability in high-risk carotid plaques are reduced by statins. 61 54
18295103 2008
4
High serum level of matrix metalloproteinase-1 and its rapid surge after intervention in patients with significant carotid atherosclerosis. 54 61
18218585 2008
5
Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP. 61 54
18605956 2008
6
Metalloproteinase expression in carotid plaque and its correlation with plasma levels before and after carotid endarterectomy. 61 54
18166633 2007
7
Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis. 54 61
17194891 2007
8
Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1. 61 54
17268019 2007
9
Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis. 61 54
17030690 2006
10
Polymorphisms in the PON gene cluster are associated with Alzheimer disease. 61 54
16319130 2006
11
Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis. 61 54
16107361 2005
12
Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism. 61 54
15486068 2005
13
Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis. 61 54
15337875 2004
14
Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells. 61 54
14977886 2004
15
Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis. 61 54
12578864 2003
16
Serial measurement of surface expressions of CD63, P-selectin and CD40 ligand on platelets in atherosclerotic ischemic stroke. A possible role of CD40 ligand on platelets in atherosclerotic ischemic stroke. 61 54
13130179 2003
17
Thrombocyte activation increases with the degree of carotid artery stenosis. 61 54
17903894 2002
18
Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. 61 54
12364729 2002
19
Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease. 61 54
11388660 2001
20
Quantitative susceptibility mapping of carotid plaques using nonlinear total field inversion: Initial experience in patients with significant carotid stenosis. 61
32141644 2020
21
Propensity-Matched Outcomes of Transcarotid Artery Revascularization Versus Carotid Endarterectomy. 61
32222590 2020
22
Haptoglobin genotype 2-2 associated with atherosclerosis in patients with ischemic stroke. 61
32439379 2020
23
Older age and duration of exposure to type 2 diabetes in selective screening of asymptomatic carotid artery stenosis for primary stroke prevention-A single institution experience. 61
31744790 2020
24
Can Carotid Endarterectomy be Performed Safely within 14 days after Intravenous Thrombolysis for Acute Stroke? 61
31918038 2020
25
Choroidal thickness in patients with cardiovascular disease: A review. 61
31923478 2020
26
Diagnostic accuracy of various EEG changes during carotid endarterectomy to detect 30-day perioperative stroke: A systematic review. 61
32403063 2020
27
Stroke Prevention: A Lifetime of Lessons. 61
32498662 2020
28
Multifocal arterial disease: clinical implications and management. 61
32371620 2020
29
Mild carotid stenosis creates gradual, progressive, lifelong brain, and eye damage: An experimental laboratory rat model. 61
31891180 2020
30
Light-Induced Amaurosis-A Case Report and Brief Literature Review. 61
32027984 2020
31
Identification of patients with carotid stenosis using natural language processing. 61
32103365 2020
32
Asymptomatic carotid stenosis revisited with nose to the grindstone. 61
32259620 2020
33
Retinal artery occlusion does not portend an increased risk of stroke. 61
31843299 2020
34
Irregularity of Carotid Plaque Surface Predicts Subsequent Vascular Event: A MRI Study. 61
31944452 2020
35
A systematic review and meta-analysis of complication rates after carotid procedures performed by different specialties. 61
32139311 2020
36
Treatment of Carotid Restenosis Using Transcarotid Revascularization. 61
32394802 2020
37
Endovascular Repair of Carotid Artery Pseudoaneurysm using Transcarotid Artery Revascularization Flow Reversal Technique. 61
31926273 2020
38
Safety and Feasibility of Simultaneous Transcarotid Revascularization With Flow Reversal and Coronary Artery Bypass Grafting for Concomitant Carotid Artery Stenosis and Coronary Artery Disease. 61
32319354 2020
39
The Impact of the Affordable Care Act Medicaid Expansion on Vascular Surgery. 61
31923598 2020
40
A Systematic Review and Updated Metaanalysis for Carotid Near-Occlusion. 61
31706996 2020
41
Defining the threshold surgeon volume associated with improved patient outcomes for carotid endarterectomy. 61
32085960 2020
42
Epidemiological Analysis of Carotid Artery Stenosis Intervention during 10 years in the Public Health System in the Largest City in Brazil: Stenting Has Been More Common than Endarterectomy. 61
31931132 2020
43
Simultaneous internal carotid artery stenosis and ipsilateral anterior communicating artery saccular aneurysm treatment: a case report. 61
32461781 2020
44
Relevance of Distal Arterial Collapse in Stenting of Atherosclerotic Near-Occlusion of the Carotid Artery. 61
32499248 2020
45
Long-term Mortality after Carotid Stenting. 61
32526358 2020
46
Increased Serum CRP-Albumin Ratio Is Independently Associated With Severity of Carotid Artery Stenosis. 61
32527139 2020
47
Evolution of Stroke Thrombectomy Techniques to Optimize First-Pass Complete Reperfusion. 61
32419724 2020
48
Ultrasound risk marker variability in symptomatic carotid plaque: impact on risk reclassification and association with temporal variation pattern. 61
32144637 2020
49
Emergent Carotid Endarterectomy with Open Thrombectomy for Acute Carotid Stent Occlusion. 61
32142949 2020
50
Circulating miR-106b-5p serves as a diagnostic biomarker for asymptomatic carotid artery stenosis and predicts the occurrence of cerebral ischemic events. 61
32558619 2020

Variations for Carotid Stenosis

ClinVar genetic disease variations for Carotid Stenosis:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 RNF213 NM_001256071.3(RNF213):c.11659A>G (p.Lys3887Glu)SNV Uncertain significance 523426 rs1555673862 17:78337499-78337499 17:80363699-80363699

Expression for Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for Carotid Stenosis

Pathways related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 VCAM1 SPP1 MMP9 MMP1 ICAM1
2
Show member pathways
12.28 VCAM1 SELE NOS3 ICAM1
3
Show member pathways
12.13 TNF MTHFR ICAM1 F7 CRP APOE
4 12.04 VCAM1 SELP SELE ICAM1
5 11.91 VCAM1 TNF MMP9 MMP1 ICAM1
6 11.9 TNF SELP MMP9 ICAM1
7 11.88 VCAM1 TNF SELE MMP9 ICAM1
8 11.88 VCAM1 TNF SELE NOS3 MMP9 ICAM1
9 11.77 VCAM1 TNF SELE NOS3 ICAM1
10 11.69 SELE MMP1 ICAM1
11 11.55 TNF SPP1 MMP9
12 11.45 TNFRSF11B TNF SPP1 APOE
13 11.43 VCAM1 SELE NOS3 ICAM1
14 11.32 SELE MMP9 MMP1
15 11.27 VCAM1 TNF SELE ICAM1
16 11.26 NOS3 MMP9 MMP1
17 11.25 VCAM1 TNF SELP SELE ICAM1
18 11.22 MMP9 APOE ACE
19 11.03 TNF SELP MMP9 LPA ICAM1
20
Show member pathways
10.9 VCAM1 TNF SELE MMP9 MMP1 ICAM1
21 10.89 VCAM1 TNF ICAM1

GO Terms for Carotid Stenosis

Cellular components related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNFRSF11B TNF SPP1 SERPINA12 S100B MMP9
2 external side of plasma membrane GO:0009897 9.55 VCAM1 TNF SELP ICAM1 ACE
3 extracellular space GO:0005615 9.5 VCAM1 TNFRSF11B TNF SPP1 SERPINA12 SELP

Biological processes related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.91 VCAM1 SPP1 SELP SELE ICAM1 HABP2
2 inflammatory response GO:0006954 9.89 TNF SPP1 SELP SELE CRP
3 proteolysis GO:0006508 9.88 MMP9 MMP1 LPA HABP2 F7 ACE
4 response to lipopolysaccharide GO:0032496 9.78 SELP SELE NOS3 ICAM1
5 cytokine-mediated signaling pathway GO:0019221 9.77 VCAM1 TNF MMP9 MMP1 ICAM1
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.72 TNF SERPINA12 SELP
7 leukocyte migration GO:0050900 9.72 TNF SELP SELE MMP1 ICAM1
8 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.56 VCAM1 SELP SELE ICAM1
9 negative regulation of lipid storage GO:0010888 9.54 TNF CRP
10 negative regulation of platelet activation GO:0010544 9.52 NOS3 APOE
11 positive regulation of leukocyte tethering or rolling GO:1903238 9.51 SELP SELE
12 membrane to membrane docking GO:0022614 9.46 VCAM1 ICAM1
13 leukocyte cell-cell adhesion GO:0007159 9.46 VCAM1 SELP SELE ICAM1
14 leukocyte tethering or rolling GO:0050901 9.26 VCAM1 TNF SELP SELE
15 extracellular matrix organization GO:0030198 9.17 VCAM1 TNFRSF11B TNF SPP1 MMP9 MMP1

Molecular functions related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.63 MMP9 MMP1 LPA HABP2 F7 ACE
2 oligosaccharide binding GO:0070492 9.26 SELP SELE
3 endopeptidase activity GO:0004175 9.26 MMP9 MMP1 F7 ACE
4 serine-type endopeptidase activity GO:0004252 9.02 MMP9 MMP1 LPA HABP2 F7

Sources for Carotid Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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