CTS1
MCID: CRP001
MIFTS: 67

Carpal Tunnel Syndrome (CTS1)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Carpal Tunnel Syndrome

MalaCards integrated aliases for Carpal Tunnel Syndrome:

Name: Carpal Tunnel Syndrome 56 12 74 25 53 29 54 6 42 43 15 62 17 71 32
Carpal Tunnel Syndrome, Familial 56 13 6 39 71
Cts 56 25 73 17
Amyotrophy, Thenar, of Carpal Origin 56 25
Cts1 56 73
Compression Neuropathy, Carpal Tunnel 25
Entrapment Neuropathy, Carpal Tunnel 25
Thenar Amyotrophy of Crapal Origin 73
Median Neuropathy, Carpal Tunnel 25
Carpal Tunnel Median Neuropathy 12
Distal Median Nerve Compression 25
Median Neuropathy Carpal Tunnel 73
Familial Carpal Tunnel Syndrome 36
Distal Median Nerve Entrapment 25
Cts - Carpal Tunnel Syndrome 12
Carpal Tunnel Syndrome 1 73
Median Nerve Entrapment 12
Carpal Tunnel 25
Carpal Canal 25

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
carpal tunnel syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:12169
OMIM 56 115430
KEGG 36 H00798
ICD9CM 34 354.0
MeSH 43 D002349
NCIt 49 C34450
SNOMED-CT 67 57406009
ICD10 32 G56.0 G56.00
MedGen 41 C0007286
UMLS 71 C0007286 C3468338

Summaries for Carpal Tunnel Syndrome

Genetics Home Reference : 25 Carpal tunnel syndrome is a disorder caused by disturbances in nerve function (neuropathy), leading to pain and numbness or tingling (paresthesia) primarily in the wrist and hand. While carpal tunnel syndrome can occur at any age, it most often affects people between the ages of 40 and 60. In more than half of cases, both hands are affected; however, the severity may vary between hands. When only one hand is affected, it is most often the hand used for writing (the dominant hand). In carpal tunnel syndrome, the pain or paresthesia is usually felt in the wrist, the palm, and the first four fingers of the hand. These signs and symptoms often develop during sleep and are noticeable upon waking. Affected individuals typically shake their hand to get rid of the pain and numbness, a characteristic move known as the flick sign. As the condition advances, the signs and symptoms begin to occur during the day as well. Affected individuals may have difficulty performing manual tasks such as turning doorknobs, fastening buttons, or opening jars. The symptoms of carpal tunnel syndrome may be triggered by certain activities that flex or extend the wrist, such as driving, typing, or holding a telephone. Over time, people with carpal tunnel syndrome can have muscle and nerve wasting (atrophy) in the affected hand and a reduced ability to detect sensations, which can be mistaken for an improvement of symptoms.

MalaCards based summary : Carpal Tunnel Syndrome, also known as carpal tunnel syndrome, familial, is related to neuropathy, hereditary, with liability to pressure palsies and normal pressure hydrocephalus, and has symptoms including seizures, tremor and back pain. An important gene associated with Carpal Tunnel Syndrome is TTR (Transthyretin), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. The drugs Betamethasone and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and breast, and related phenotypes are peripheral neuropathy and constrictive median neuropathy

MedlinePlus : 42 You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. Suddenly, a sharp, piercing pain shoots through the wrist and up your arm. Just a passing cramp? It could be carpal tunnel syndrome. The carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. It contains nerve and tendons. Sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. Symptoms usually start gradually. As they worsen, grasping objects can become difficult. Often, the cause is having a smaller carpal tunnel than other people do. Other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. Women are three times more likely to have carpal tunnel syndrome than men. Early diagnosis and treatment are important to prevent permanent nerve damage. Your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. Treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

NINDS : 53 Carpal tunnel syndrome (CTS) occurs when  the median nerve, which runs from the forearm into the palm of the hand,  becomes pressed or squeezed at the wrist. The carpal tunnel is a narrow, rigid passageway of ligament and bones at the base of the hand that houses the median nerve and the tendons that bend the fingers. The median nerve provides feeling to the palm side of the thumb and to most of the fingers. Symptoms usually start gradually, with numbness, tingling, weakness, and sometimes pain in the hand and wrist.  CTS makes it difficult for some people to drive, read a book, grasp small objects, or do other tasks. Sometimes no direct cause of CTS can be found; contributing factors include trauma or injury to the wrist that causes swelling, as well as thyroid disease, rheumatoid arthritis, and fluid retention during pregnancy. Women are three times more likely than men to develop carpal tunnel syndrome. The disorder usually occurs only in adults.

KEGG : 36 Carpal tunnel syndrome is an entrapment neuropathy of the median nerve characterized by paresthesias in the district of the median nerve. Familial carpal tunnel syndrome is an extremely rare form with bilateral symptom that is frequently associated with inherited systemic disorders such as mucopolysaccharidosis, mucolipidosis, amyloidosis, collagen vascular disease or hereditary liability to pressure palsies. The cause of the disease is the compression of the median nerve by thickened transverse carpal ligament. Mutations in transthyretin, a gene that plays a role in deposition of amyloid, have been reported.

UniProtKB/Swiss-Prot : 73 Carpal tunnel syndrome 1: A condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.

PubMed Health : 62 About carpal tunnel syndrome: Most people's hands briefly "fall asleep" every now and then. They then feel numb or tingly. Although this is a little unpleasant, it's usually over very quickly. Carpal tunnel syndrome has similar symptoms – but they keep coming back again and are often painful. The carpal tunnel is a passageway inside of the wrist that is surrounded by bones and connective tissue. It runs along the inner side of the wrist to the base of the hand and is covered by a strong, fibrous band made up of connective tissue, called the flexor retinaculum. The carpal tunnel contains tendons and the median nerve. This nerve is responsible for sensation and movement in the ball of the thumb and some parts of the hand. If the tissue inside the carpal tunnel swells up, it can put pressure on the median nerve, which is what causes carpal tunnel syndrome. The symptoms often go away on their own, but they can sometimes last for quite a long time. There are a number of different treatments that can provide relief.

Wikipedia : 74 Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels... more...

More information from OMIM: 115430

Related Diseases for Carpal Tunnel Syndrome

Diseases related to Carpal Tunnel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3559)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary, with liability to pressure palsies 33.5 SH3TC2 PMP22 MPZ
2 normal pressure hydrocephalus 32.4 VEGFA TTR ACE
3 papilledema 32.3 VEGFA IL1RN ACE
4 fallopian tube carcinoma 32.2 VEGFA PGR ESR1
5 vascular dementia 32.1 VEGFA IL6 IL1B ACE
6 median neuropathy 31.9 TTR PMP22 COL5A1
7 mononeuropathy 31.7 TAC1 SH3TC2 PMP22 MPZ
8 neuropathy 31.7 VEGFA SH3TC2 PMP22 MPZ ACE
9 radiculopathy 31.5 TAC1 IL6 CCL2
10 amyloidosis 31.4 TTR INS IL6 IL1RN B2M
11 synovitis 31.1 VEGFA IL6 IL1RN IL1B
12 appendicitis 31.1 IL6 IL1B CCL2
13 fasciitis 30.9 IL6 IL1RN ESR1
14 meningoencephalitis 30.9 TAC1 IL6 B2M
15 arthropathy 30.9 IL6 IL1RN IL1B B2M
16 idiopathic interstitial pneumonia 30.9 VEGFA TGFB1 CCN2 CCL2
17 temporal arteritis 30.8 IL6 IL1RN CCL2
18 peripheral nervous system disease 30.8 VEGFA TTR TAC1 SH3TC2 PMP22 MPZ
19 aortic aneurysm, familial abdominal, 1 30.8 IL6 CCL2 ACE
20 plasma cell neoplasm 30.8 VEGFA TTR IL6 B2M
21 sleep disorder 30.8 INS IL6 ACE
22 dupuytren contracture 30.8 VEGFA TGFB1 IL1B
23 neuromuscular disease 30.7 SH3TC2 PMP22 MPZ IL6
24 foot drop 30.7 PMP22 MPZ
25 sensory peripheral neuropathy 30.7 TAC1 SH3TC2 PMP22 MPZ
26 diabetic neuropathy 30.7 VEGFA PMP22 MPZ INS ACE
27 fibromyalgia 30.7 INS IL6 IL1B CCL2
28 pericardial effusion 30.7 VEGFA TTR IL6 ACE
29 frozen shoulder 30.6 TGFB1 IL1B COL1A1
30 systemic scleroderma 30.6 TGFB1 INS IL6 CCN2 ACE
31 intermediate coronary syndrome 30.6 INS IL6 ACE
32 anthracosis 30.6 TGFB1 IL6 CCL2
33 end stage renal failure 30.6 TGFB1 IL6 IL1RN ACE
34 charcot-marie-tooth disease, demyelinating, type 1a 30.6 SH3TC2 PMP22 MPZ
35 microvascular complications of diabetes 3 30.6 TGFB1 INS CCN2 ACE
36 pleural disease 30.6 VEGFA IL6 IL1B
37 angina pectoris 30.5 INS IL6 ACE
38 uremia 30.5 INS IL6 B2M ACE
39 tuberculous meningitis 30.5 VEGFA TGFB1 CCL2
40 interstitial lung disease 30.5 TGFB1 IL6 IL1B CCL2
41 portal hypertension 30.5 VEGFA TGFB1 INS CCN2 ACE
42 scleroderma, familial progressive 30.5 COL1A1 CCN2
43 osteoarthritis 30.5 TGFB1 IL6 IL1RN IL1B
44 sarcoidosis 1 30.5 IL1RN IL1B CCL2 ACE
45 congestive heart failure 30.5 VEGFA INS IL6 ACE
46 neuritis 30.5 PMP22 MPZ IL6 IL1B CCL2
47 hydronephrosis 30.4 VEGFA TGFB1 IL6 CCL2 B2M
48 peripheral vascular disease 30.4 VEGFA INS IL6 ACE
49 cerebrovascular disease 30.4 TTR INS IL6 ACE
50 polyneuropathy 30.4 VEGFA TTR SH3TC2 PMP22 MPZ INS

Graphical network of the top 20 diseases related to Carpal Tunnel Syndrome:



Diseases related to Carpal Tunnel Syndrome

Symptoms & Phenotypes for Carpal Tunnel Syndrome

Human phenotypes related to Carpal Tunnel Syndrome:

31
# Description HPO Frequency HPO Source Accession
1 peripheral neuropathy 31 HP:0009830
2 constrictive median neuropathy 31 HP:0012185
3 reduced circulating vitamin b6 level 31 HP:0008326
4 digital flexor tenosynovitis 31 HP:0012276

Symptoms via clinical synopsis from OMIM:

56
Neuro:
constrictive median neuropathy
tunnel sign

Misc:
responsive to pyridoxine administration
early onset age

Limbs:
digital flexor tenosynovitis
thickened transverse carpal ligament

Lab:
vitamin b6 deficiency

Clinical features from OMIM:

115430

UMLS symptoms related to Carpal Tunnel Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, muscle cramp

MGI Mouse Phenotypes related to Carpal Tunnel Syndrome:

45 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 ACE B2M CCN2 COL1A1 COL5A1 ESR1
2 homeostasis/metabolism MP:0005376 10.41 ACE B2M CCN2 COL1A1 ESR1 IL1B
3 growth/size/body region MP:0005378 10.38 ACE B2M CCN2 COL1A1 COL5A1 ESR1
4 behavior/neurological MP:0005386 10.37 ACE COL1A1 ESR1 IL6 INS MPZ
5 cellular MP:0005384 10.35 B2M CCN2 COL1A1 ESR1 IL1RN IL6
6 mortality/aging MP:0010768 10.34 ACE B2M CCN2 COL1A1 COL5A1 ESR1
7 integument MP:0010771 10.32 B2M CCN2 COL1A1 COL5A1 ESR1 IL1B
8 immune system MP:0005387 10.31 ACE B2M CCL2 COL1A1 ESR1 IL1B
9 hematopoietic system MP:0005397 10.3 ACE B2M COL1A1 ESR1 IL1B IL1RN
10 embryo MP:0005380 10.26 ACE B2M CCN2 COL1A1 COL5A1 ESR1
11 endocrine/exocrine gland MP:0005379 10.25 ACE B2M CCN2 COL1A1 ESR1 IL6
12 digestive/alimentary MP:0005381 10.22 B2M CCN2 COL1A1 ESR1 IL6 INS
13 adipose tissue MP:0005375 10.14 ACE COL1A1 ESR1 IL6 INS MPZ
14 liver/biliary system MP:0005370 10.11 ACE B2M CCN2 COL1A1 ESR1 IL6
15 muscle MP:0005369 10.06 COL1A1 ESR1 IL6 INS PGR PMP22
16 nervous system MP:0003631 10.06 B2M COL1A1 ESR1 IL1B IL6 INS
17 neoplasm MP:0002006 10.02 ACE B2M COL1A1 ESR1 IL1B IL6
18 reproductive system MP:0005389 9.93 ACE B2M COL1A1 ESR1 IL1RN IL6
19 renal/urinary system MP:0005367 9.91 ACE COL1A1 ESR1 IL6 INS TAC1
20 skeleton MP:0005390 9.73 CCN2 COL1A1 ESR1 IL1B IL1RN IL6
21 vision/eye MP:0005391 9.28 CCN2 COL1A1 COL5A1 IL6 INS PMP22

Drugs & Therapeutics for Carpal Tunnel Syndrome

PubMed Health treatment related to Carpal Tunnel Syndrome: 62

Mild to moderate carpal tunnel syndrome can usually be treated with a splint at first. The splint is worn at night to prevent the wrist from bending too far. Doctors may also advise you to avoid activities thought to be related to this condition. Injecting corticosteroids into the carpal tunnel can provide temporary relief, but corticosteroid injections aren't an effective long-term solution. Surgery may also be considered as a treatment . During the operation , the flexor retinaculum that arches across the base of the hand is cut: to reduce pressure on the median nerve . This procedure can make the symptoms go away for good, but it's not always necessary. Other treatments are usually preferred, especially in early stages of the condition. Immediate surgery is only needed in very rare cases of acute carpal tunnel syndrome . Other treatments such as acupuncture , ultrasound therapy , laser therapy or magnetic field therapy may also be recommended. But there is no evidence that they are effective in the treatment of carpal tunnel syndrome . Many people take painkillers to relieve their symptoms – particularly non-steroidal anti-inflammatory drugs (NSAIDs), which are available over-the-counter at pharmacies and drugstores. Taking vitamin B6 products is sometimes also recommended to strengthen the nerves . So far, though, research suggests that neither NSAIDs nor vitamin B6 can provide enough pain relief.

Drugs for Carpal Tunnel Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 187)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
tannic acid Approved Phase 4 1401-55-4
3
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
4
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
5
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
6
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
7
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
8
lanreotide Approved Phase 4 108736-35-2
9
Somatostatin Approved, Investigational Phase 4 51110-01-1, 38916-34-6 53481605
10
Prilocaine Approved Phase 4 721-50-6 4906
11
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
12
Cefazolin Approved Phase 4 25953-19-9 656510 33255
13
Vancomycin Approved Phase 4 1404-90-6 441141 14969
14
Allantoin Approved Phase 4 97-59-6 204
15
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
16
Racepinephrine Approved Phase 4 329-65-7 838
17
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
18
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
19 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
20
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
21
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
22
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
23
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
24
Ibuprofen Approved Phase 4 15687-27-1 3672
25
Acetaminophen Approved Phase 4 103-90-2 1983
26
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
27
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
28
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
29
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
30
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
31 Anti-Asthmatic Agents Phase 4
32 Betamethasone benzoate Phase 4
33 Betamethasone Valerate Phase 4 2152-44-5
34 Betamethasone sodium phosphate Phase 4
35 Betamethasone-17,21-dipropionate Phase 4
36 Tranquilizing Agents Phase 4
37 Psychotropic Drugs Phase 4
38 Alpha-lipoic Acid Phase 4
39 Antioxidants Phase 4
40 Thioctic Acid Phase 4
41 Neurotransmitter Agents Phase 4
42 Anti-Anxiety Agents Phase 4
43 Ketorolac Tromethamine Phase 4
44 retinol Phase 4
45 Retinol palmitate Phase 4
46 Adjuvants, Anesthesia Phase 4
47 Hypnotics and Sedatives Phase 4
48 GABA Agents Phase 4
49 Anesthetics, General Phase 4
50 Anesthetics, Intravenous Phase 4

Interventional clinical trials:

(show top 50) (show all 283)
# Name Status NCT ID Phase Drugs
1 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration: Clinical Randomized Trial Unknown status NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
2 Randomised, Multicentre, Open Label, Parallel Group Pragmatic Clinical Trial of Local Steroid Injection Versus Night Splinting in Mild to Moderate Carpal Tunnel Syndrome (CTS) Completed NCT02038452 Phase 4 Depo-Medrone
3 The Association of Alpha Lipoic Acid to the Median Nerve Decompression in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
4 Length of Postoperative Dressing After Mini-open Carpal Tunnel Release: A Randomized Prospective Comparison Completed NCT01310218 Phase 4
5 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
6 Comparing Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol Administration for Carpal Tunnel Release and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
7 Onset and Duration of Forearm Nerve Blockade Performed With a Single Distal Injection Versus Sequential Injections at Distal and Proximal Locations Alongside the Nerves: A Blinded Randomized Completed NCT03649763 Phase 4 Lidocaine;Bupivacaine;Lidocaine
8 Circumferential Versus Not Circumferential Distribution of Mepivacaine Around the Median and Ulnar Nerves in the Carpal Tunnel Surgery. Randomized Clinical Trial, Double Blinded. Completed NCT01603680 Phase 4
9 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome (Cts): A Randomized, Placebo-Controlled Trial With Secondary Bayesian Modification Completed NCT00277563 Phase 4
10 Extended Follow-up of a Randomized Placebo-controlled Trial of Local Steroid Injection in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
11 Bupivacaine Versus Lidocaine Local Anesthesia in Elective Outpatient Hand Surgery: A Randomized Controlled Trial Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
12 Local Steroid Injection vs Wrist Splinting for Carpal Tunnel Syndrome: A Randomized Clinical Trial Completed NCT02140632 Phase 4
13 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
14 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
15 A Multicenter, Open, Prospective, Observational Study to Investigate the Effect of Lanreotide Autogel 120 mg on Control of GH and IGF-I Excess and Tumor Shrinkage in Newly Diagnosed Patients With Acromegaly Completed NCT00627796 Phase 4 Lanreotide-Autogel 120 mg
16 Ultrasound-guided Block of the Brachial Plexus Using Prilocaine: Effects of Local-anesthetic Dose Reduction on Parameters of Block Quality and Adverse Effects in Outpatients Completed NCT01309360 Phase 4 midazolam;prilocaine 1%;prilocaine 1%;prilocaine 1%
17 Examining the Efficacy of Low Intensity Low Frequency Surface Acoustic Wave Ultrasound(LILF/SAWU) in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
18 Endoscopic Carpal Tunnel Release, Infection Incidence, and Prophylactic Antibiotics: Indicated or Kick the Habit? Recruiting NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
19 Pain Reduction and Changes in Upper Limb Function Produced by Physiotherapy, Ibuprofen Arginine, Gabapentin and the Absence of Treatment, in Carpal Tunnel Syndrome Recruiting NCT04025203 Phase 4 Ibuprofen Arginine;Gabapentin
20 The Effect of Theraworx Foam on the Cross-sectional Area of the Median Nerve in Patients With Carpal Tunnel Syndrome Recruiting NCT04017390 Phase 4 Theraworx Foam;Placebo Foam
21 Exparel and Education to Avoid Opioids After Carpal Tunnel Release Recruiting NCT03867539 Phase 4
22 A Randomized, Controlled Trial Comparing Combination Therapy of Ibuprofen + Acetaminophen Versus Hydrocodone + Acetaminophen for the Treatment of Pain After Carpal Tunnel Surgery Recruiting NCT01974609 Phase 4 Narcotic;non-narcotic
23 Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture: A Prospective, Randomized Study Recruiting NCT03749616 Phase 4 Ibuprofen;Acetaminophen
24 Pain Reduction Produced by Physiotherapy, Ibuprofen, and the Absence of Treatment, in Carpal Tunnel Syndrome Not yet recruiting NCT04119739 Phase 4 Ibuprofen
25 Comparison of the Efficacy of Corticosteroid Injection and Extracorporeal Shock Wave Therapy (ESWT) in Patients With Carpal Tunnel Syndrome; A Prospective Randomized Controlled Trial Not yet recruiting NCT03792945 Phase 4 local injection
26 Satisfaction With Pain Relief After Carpal Tunnel Release Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
27 A Randomized, Double-blind Controlled Trial of Bupivacaine Extended-release Liposome Injection for Postsurgical Analgesia in Patients Undergoing Open-reduction Internal Fixation of the Distal Radius Terminated NCT02515851 Phase 4 Exparel;Placebo
28 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery: A Randomized, Double Blind Comparison of Acetaminophen/Ibuprofen Versus Acetaminophen/Hydrocodone Terminated NCT02029235 Phase 4 Acetaminophen/Ibuprofen;Acetaminophen/Hydrocodone
29 Comparison Results of Carpal Tunnel Release Between Standard Incision and Limited Incision Using PSU Retractor: A Randomized Controlled Trial Unknown status NCT01017471 Phase 3
30 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Unknown status NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
31 The Effect of Pre-operative and/or Post-operative Electrical Stimulation on Enhancing Regeneration of Peripheral Sensory Nerve Regeneration in Human Hand, a Double Blind Randomized Controlled Study. Unknown status NCT03205124 Phase 2, Phase 3
32 Gabapentin for Carpal Tunnel Syndrome: A Randomised Controlled Trial Completed NCT00137735 Phase 3 Gabapentin
33 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
34 Effect of Preoperative Gabapentine for Carpal Tunnel Syndrome Completed NCT01632215 Phase 3 Gabapentine
35 Local Steroid Injection in the Treatment of Idiopathic Carpal Tunnel Syndrome: A Randomized Double-blind Placebo-controlled Trial Among Patients Planned for Surgical Treatment Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
36 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial. Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
37 Comparison of Local Steroid Injection With Platelet Rich Plasma in the Treatment of Carpal Tunnel Syndrome Recruiting NCT04000932 Phase 3 Local platelet rich plasma (PRP) injection-T-Lab PRP kit;Local steroid injection-Diprospan ®, Schering Plough
38 Assessment of 18F-Florbetaben Whole-body PET Imaging for the Comprehensive Detection of Cardiac and Extracardiac Sites of Amyloid Deposits Not yet recruiting NCT03616496 Phase 3 Neuraceq 300MBq/mL Solution for Injection for PET imaging
39 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
40 A Randomized, Double-Blind Study Comparing the Safety and Efficacy of the Lidocaine Patch 5% With Placebo in Patients With Pain From Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
41 A Phase III, Randomized, Open-label Study to Assess the Safety and Efficacy of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
42 Instiutional Review Board of Chung Shan Medical University Hospital Unknown status NCT00514462 Phase 1, Phase 2
43 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
44 A Prospective, Randomized Trial of Preoperative Lanreotide Treatment in Acromegalic Patients With Macroadenomas Unknown status NCT00993356 Phase 2 Preoperative lanreotide treatment
45 Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome, a Preliminary Study Completed NCT00634738 Phase 1, Phase 2
46 Mechanisms of Neural Mobilization in the Treatment of Chronic Pain Completed NCT00929123 Phase 1, Phase 2
47 Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome: a Preliminary Study. Completed NCT00634699 Phase 1, Phase 2
48 Effectiveness of Alpha Lipoic Acid on Clinical and Electrophysiological Recovery in Patients With Carpal Tunnel Syndrome Surgical Release Completed NCT02382328 Phase 2 alpha lipoic acid;Placebo
49 Ultrasound-assisted Percutaneous Release of Carpal Tunnel Syndrome Completed NCT02514317 Phase 2
50 Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome Completed NCT01093209 Phase 2

Search NIH Clinical Center for Carpal Tunnel Syndrome

Cochrane evidence based reviews: carpal tunnel syndrome

Genetic Tests for Carpal Tunnel Syndrome

Genetic tests related to Carpal Tunnel Syndrome:

# Genetic test Affiliating Genes
1 Carpal Tunnel Syndrome 29 TTR

Anatomical Context for Carpal Tunnel Syndrome

MalaCards organs/tissues related to Carpal Tunnel Syndrome:

40
Testes, Bone, Breast, Thyroid, Lung, Kidney, Heart

Publications for Carpal Tunnel Syndrome

Articles related to Carpal Tunnel Syndrome:

(show top 50) (show all 8191)
# Title Authors PMID Year
1
Familial carpal tunnel syndrome due to amyloidogenic transthyretin His 114 variant. 61 56 6
8309582 1994
2
DNA rearrangements on both homologues of chromosome 17 in a mildly delayed individual with a family history of autosomal dominant carpal tunnel syndrome. 54 61 56
9973284 1999
3
Familial carpal tunnel syndrome: further evidence for a genetic contribution. 61 56
16433699 2006
4
Hereditary neuropathy with liability to pressure palsies is not a major cause of idiopathic carpal tunnel syndrome. 61 56
11594922 2001
5
Is there a familial carpal tunnel syndrome? An evaluation and literature review. 61 56
9771681 1998
6
Autosomal dominant carpal tunnel syndrome. 61 56
9831348 1998
7
Mutilating hand syndrome in an infant with familial carpal tunnel syndrome. 61 56
9427229 1998
8
Familial carpal-tunnel syndrome presenting in childhood. Report of two cases. 61 56
3597507 1987
9
[Familial thenar amyotrophy of carpal origin]. 61 56
4089404 1985
10
Genetic linkage analysis of the carpal tunnel syndrome. 61 56
4043979 1985
11
Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. 61 56
6961425 1982
12
Familial bilateral carpal tunnel syndrome. 61 56
7241167 1981
13
Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome. 61 56
484522 1979
14
Primary familial bilateral carpal tunnel syndrome. 61 56
464452 1979
15
Familial carpal tunnel syndrome with onset in childhood. 61 56
1141922 1975
16
CARPAL TUNNEL SYNDROME IN CHILDHOOD: REPORT OF A CASE. 61 56
14341079 1965
17
Polydeoxyribonucleotide injection in the treatment of patients with carpal tunnel syndrome: Retrospective preliminary study. 61 42
31593124 2019
18
Effect of extracorporeal shockwave therapy on carpal tunnel syndrome: A systematic review and meta-analysis of randomized controlled trials. 61 42
31415424 2019
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Efficacy of laser acupuncture for carpal tunnel syndrome: A study protocol for a prospective double-blind randomized controlled trial. 61 42
31348263 2019
20
Familial occurrence of entrapment neuropathies. 56
444109 1979
21
Survey and new data on treatment with pyridoxine of patients having a clinical syndrome including the carpal tunnel and other defects. 56
877401 1977
22
Improved and effective assays of the glutamic oxaloacetic transaminase by the coenzyme-apoenzyme system (CAS) principle. 56
966077 1976
23
Human deficiencies of vitamin B6. I. Studies on parameters of the assay of the glutamic oxaloacetic transaminase by the CAS principle. 56
1197932 1975
24
Non-senile wild-type transthyretin systemic amyloidosis presenting as bilateral carpal tunnel syndrome. 54 61
18601659 2008
25
A new transthyretin variant (Glu61Gly) associated with cardiomyopathy. 54 61
17453626 2007
26
Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. 54 61
16266291 2005
27
Results of endoscopic management of primary versus recurrent carpal tunnel syndrome in long-term haemodialysis patients. 54 61
15810101 2004
28
Some implications of genetic biomarkers in occupational epidemiology and practice. 54 61
15018031 2004
29
Assessment of the scientific basis for genetic testing of railroad workers with carpal tunnel syndrome. 54 61
12802212 2003
30
A transthyretin mutation (Tyr78Phe) associated with peripheral neuropathy, carpal tunnel syndrome and skin amyloidosis. 54 61
12762139 2003
31
[Hereditary amyloidoses associated with transthyretin mutations]. 54 61
12376880 2002
32
Familial amyloid polyneuropathy in a Spanish family with a transthyretin deletion (deltaVal 122) presenting with carpal tunnel syndrome. 54 61
11140845 2000
33
[Metabolic and nutritional neuropathies]. 54 61
10853552 2000
34
[Amyloidosis and renal failure]. 54 61
10592739 1999
35
[Usefulness of magnetic resonance imaging of the wrist for the early diagnosis of dialysis-related amyloidosis]. 54 61
10077983 1999
36
Serum beta 2-microglobulin levels in patients chronically dialyzed with CA-210 versus CT-190 dialysis membranes. 54 61
9481434 1998
37
Apolipoprotein E and alpha 1-antichymotrypsin in dialysis-related amyloidosis. 54 61
9350687 1997
38
[Dynamic change of beta 2-microglobulin in hemodialysis]. 54 61
9387629 1996
39
Diagnostic aspects of beta 2-microglobulin amyloidosis. 54 61
8804016 1996
40
Detection of modified beta 2-microglobulin (beta 2m) from amyloid deposits in tenosynovial tissue of carpal tunnel syndrome (CTS) 54 61
7955417 1994
41
Amyloid and peripheral nervous system disease. 54 61
8187375 1994
42
Carpal tunnel syndrome: a major complication in hemodialysis patients. 54 61
7973484 1994
43
[Clinical and genetic heterogeneity in familial amyloidotic polyneuropathy associated with variant transthyretin]. 54 61
8411724 1993
44
[Computerized tomography and conventional radiography in the diagnosis of destructive spondyloarthropathy. Our experience with 30 patients undergoing periodic hemodialysis]. 54 61
1494670 1992
45
Familial amyloidotic polyneuropathy presenting with carpal tunnel syndrome and a new transthyretin mutation, asparagine 70. 54 61
1436517 1992
46
Cystic radiolucencies of carpal bones, distal radius and ulna as a marker for dialysis-associated amyloid osteoarthropathy. 54 61
1436294 1992
47
New mutant gene (transthyretin Arg 58) in cases with hereditary polyneuropathy detected by non-isotope method of single-strand conformation polymorphism analysis. 54 61
1656975 1991
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[Rheumatologic complications and amyloidosis in dialysis patients]. 54 61
2183342 1990
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Comparison of Magnetic Resonance Imaging and Ultrasonography in Diagnosing and Grading Carpal Tunnel Syndrome: A Prospective Study. 61
31126663 2020
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MRI criteria for diagnosis and predicting severity of carpal tunnel syndrome. 61
31396669 2020

Variations for Carpal Tunnel Syndrome

ClinVar genetic disease variations for Carpal Tunnel Syndrome:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TTR NM_000371.3(TTR):c.148G>A (p.Val50Met)SNV Pathogenic 13417 rs28933979 18:29172937-29172937 18:31592974-31592974
2 TTR NM_000371.3(TTR):c.424G>A (p.Val142Ile)SNV Pathogenic 13426 rs76992529 18:29178618-29178618 18:31598655-31598655
3 TTR NM_000371.3(TTR):c.400T>C (p.Tyr134His)SNV Pathogenic 13449 rs121918088 18:29178594-29178594 18:31598631-31598631
4 TTR NM_000371.3(TTR):c.250T>C (p.Phe84Leu)SNV Pathogenic/Likely pathogenic 13453 rs121918091 18:29175132-29175132 18:31595169-31595169
5 TTR NM_000371.3(TTR):c.122G>A (p.Arg41Gln)SNV Uncertain significance 246463 rs879254269 18:29172911-29172911 18:31592948-31592948
6 TTR NM_000371.3(TTR):c.280G>C (p.Asp94His)SNV Uncertain significance 181695 rs730881164 18:29175162-29175162 18:31595199-31595199

UniProtKB/Swiss-Prot genetic disease variations for Carpal Tunnel Syndrome:

73
# Symbol AA change Variation ID SNP ID
1 TTR p.Tyr134His VAR_007598 rs121918088

Expression for Carpal Tunnel Syndrome

Search GEO for disease gene expression data for Carpal Tunnel Syndrome.

Pathways for Carpal Tunnel Syndrome

Pathways related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 VEGFA TGFB1 IL6 IL1B ESR1 COL5A1
2
Show member pathways
13.27 VEGFA TGFB1 PSMD9 IL6 IL1RN IL1B
3
Show member pathways
12.97 TGFB1 INS IL6 CCN2 CCL2 ACE
4
Show member pathways
12.76 VEGFA TGFB1 INS IL6 IL1B COL5A1
5
Show member pathways
12.58 VEGFA TGFB1 PGR ESR1 COL1A1
6
Show member pathways
12.25 INS IL6 IL1B CCL2
7 12.22 VEGFA TGFB1 ESR1 COL1A1
8 12.12 VEGFA TAC1 IL6 IL1RN IL1B
9 11.99 VEGFA TGFB1 INS IL6
10 11.93 TGFB1 IL6 IL1B CCL2
11 11.83 TGFB1 IL6 IL1B COL1A1
12 11.82 VEGFA TGFB1 IL6 IL1B CCL2
13 11.74 TGFB1 INS IL6 IL1B COL1A1
14 11.67 TGFB1 IL6 IL1B
15 11.62 VEGFA TGFB1 IL6 IL1B CCL2
16
Show member pathways
11.57 VEGFA IL6 IL1B
17 11.47 VEGFA TGFB1 IL6
18 11.46 TGFB1 IL6 IL1B CCL2
19 11.42 IL6 IL1RN IL1B CCL2
20 11.41 IL6 IL1B COL1A1
21 11.4 TGFB1 IL6 IL1RN IL1B CCL2
22 11.39 VEGFA TGFB1 INS IL6
23 11.17 TGFB1 IL6 IL1B
24 11.15 TGFB1 IL6 IL1B CCN2 CCL2
25 11.1 VEGFA TGFB1 IL6 IL1B COL1A1 CCL2
26 10.94 TGFB1 IL6 IL1B COL5A1 COL1A1 CCN2

GO Terms for Carpal Tunnel Syndrome

Cellular components related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 VEGFA TTR TGFB1 TAC1 INS IL6
2 endoplasmic reticulum lumen GO:0005788 9.72 INS IL6 COL5A1 COL1A1 B2M
3 extracellular matrix GO:0031012 9.65 VEGFA TGFB1 COL5A1 COL1A1 CCN2
4 extracellular space GO:0005615 9.47 VEGFA TTR TGFB1 TAC1 INS IL6
5 secretory granule GO:0030141 9.46 VEGFA TGFB1 IL1B COL1A1

Biological processes related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.06 IL6 IL1RN IL1B CCL2 B2M
2 positive regulation of transcription, DNA-templated GO:0045893 10.05 TGFB1 PSMD9 IL6 IL1B ESR1 COL1A1
3 signal transduction GO:0007165 10.02 VEGFA TTR TGFB1 PGR INS IL6
4 positive regulation of cell proliferation GO:0008284 10.01 VEGFA TGFB1 INS IL6 IL1B CCN2
5 cellular protein metabolic process GO:0044267 9.95 TTR INS IL6 B2M
6 cell-cell signaling GO:0007267 9.95 TAC1 PGR INS IL1B
7 positive regulation of protein phosphorylation GO:0001934 9.91 VEGFA TGFB1 IL1B CCN2
8 cellular response to lipopolysaccharide GO:0071222 9.91 IL6 IL1RN IL1B CCL2
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 TGFB1 INS IL6 IL1B
10 positive regulation of cell migration GO:0030335 9.85 VEGFA TGFB1 INS IL1B COL1A1
11 positive regulation of gene expression GO:0010628 9.85 VEGFA TGFB1 INS IL6 IL1B CCN2
12 cellular response to mechanical stimulus GO:0071260 9.83 TGFB1 IL1B COL1A1
13 cellular response to organic cyclic compound GO:0071407 9.81 TGFB1 IL1B CCL2
14 positive regulation of interleukin-6 production GO:0032755 9.8 IL6 IL1RN IL1B
15 myelination GO:0042552 9.79 TGFB1 PMP22 MPZ
16 response to estradiol GO:0032355 9.78 TGFB1 ESR1 COL1A1 CCN2
17 positive regulation of cell division GO:0051781 9.76 VEGFA TGFB1 IL1B
18 inflammatory response GO:0006954 9.73 TGFB1 TAC1 IL6 IL1RN IL1B CCL2
19 protein kinase B signaling GO:0043491 9.72 TGFB1 IL1B CCL2
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 TGFB1 IL1B CCL2
21 positive regulation of vascular endothelial growth factor production GO:0010575 9.69 TGFB1 IL6 IL1B
22 negative regulation of neurogenesis GO:0050768 9.67 IL6 IL1B B2M
23 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.64 TGFB1 ESR1
24 collagen biosynthetic process GO:0032964 9.64 COL5A1 COL1A1
25 neutrophil mediated immunity GO:0002446 9.63 IL6 ACE
26 cytokine-mediated signaling pathway GO:0019221 9.63 VEGFA TGFB1 IL6 IL1RN IL1B CCL2
27 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.6 IL6 IL1RN
28 connective tissue development GO:0061448 9.59 TGFB1 CCN2
29 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.56 VEGFA ACE
30 negative regulation of gap junction assembly GO:1903597 9.43 IL1B ACE
31 negative regulation of gene expression GO:0010629 9.43 VEGFA TGFB1 PGR ESR1 CCN2 ACE
32 mononuclear cell proliferation GO:0032943 9.4 TGFB1 ACE
33 positive regulation of epithelial to mesenchymal transition GO:0010718 8.92 TGFB1 IL6 IL1B COL1A1

Molecular functions related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 VEGFA TTR TGFB1 PGR INS ESR1
2 growth factor activity GO:0008083 9.46 VEGFA TGFB1 IL6 CCN2
3 cytokine activity GO:0005125 9.1 VEGFA TGFB1 IL6 IL1RN IL1B CCL2

Sources for Carpal Tunnel Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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