CTS1
MCID: CRP001
MIFTS: 66

Carpal Tunnel Syndrome (CTS1)

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Carpal Tunnel Syndrome

MalaCards integrated aliases for Carpal Tunnel Syndrome:

Name: Carpal Tunnel Syndrome 57 12 76 54 29 55 6 43 3 44 15 63 73
Carpal Tunnel Syndrome, Familial 57 13 6 40 73
Cts 57 75 3
Cts1 57 75
Amyotrophy, Thenar, of Carpal Origin 57
Thenar Amyotrophy of Crapal Origin 75
Carpal Tunnel Median Neuropathy 12
Median Neuropathy Carpal Tunnel 75
Familial Carpal Tunnel Syndrome 37
Cts - Carpal Tunnel Syndrome 12
Carpal Tunnel Syndrome 1 75
Median Nerve Entrapment 12

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
carpal tunnel syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 115430
Disease Ontology 12 DOID:12169
ICD10 33 G56.0 G56.00
ICD9CM 35 354.0
MeSH 44 D002349
NCIt 50 C34450
MedGen 42 C0007286
KEGG 37 H00798

Summaries for Carpal Tunnel Syndrome

MedlinePlus : 43 You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. Suddenly, a sharp, piercing pain shoots through the wrist and up your arm. Just a passing cramp? It could be carpal tunnel syndrome. The carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. It contains nerve and tendons. Sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. Symptoms usually start gradually. As they worsen, grasping objects can become difficult. Often, the cause is having a smaller carpal tunnel than other people do. Other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. Women are three times more likely to have carpal tunnel syndrome than men. Early diagnosis and treatment are important to prevent permanent nerve damage. Your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. Treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Carpal Tunnel Syndrome, also known as carpal tunnel syndrome, familial, is related to peripheral nervous system disease and hereditary amyloidosis, and has symptoms including back pain, headache and muscle cramp. An important gene associated with Carpal Tunnel Syndrome is TTR (Transthyretin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Phospholipase-C Pathway. The drugs Lidocaine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and thyroid, and related phenotypes are vitamin b6 deficiency and peripheral neuropathy

CDC : 3 Agriculture

NINDS : 54 Carpal tunnel syndrome (CTS) occurs when  the median nerve, which runs from the forearm into the palm of the hand,  becomes pressed or squeezed at the wrist. The carpal tunnel is a narrow, rigid passageway of ligament and bones at the base of the hand that houses the median nerve and the tendons that bend the fingers. The median nerve provides feeling to the palm side of the thumb and to most of the fingers. Symptoms usually start gradually, with numbness, tingling, weakness, and sometimes pain in the hand and wrist.  CTS makes it difficult for some people to drive, read a book, grasp small objects, or do other tasks. Sometimes no direct cause of CTS can be found; contributing factors include trauma or injury to the wrist that causes swelling, as well as thyroid disease, rheumatoid arthritis, and fluid retention during pregnancy. Women are three times more likely than men to develop carpal tunnel syndrome. The disorder usually occurs only in adults.

UniProtKB/Swiss-Prot : 75 Carpal tunnel syndrome 1: A condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.

PubMed Health : 63 About carpal tunnel syndrome: Most people's hands briefly "fall asleep" every now and then. They then feel numb or tingly. Although this is a little unpleasant, it's usually over very quickly. Carpal tunnel syndrome has similar symptoms – but they keep coming back again and are often painful.The carpal tunnel is a passageway inside of the wrist that is surrounded by bones and connective tissue. It runs along the inner side of the wrist to the base of the hand and is covered by a strong, fibrous band made up of connective tissue, called the flexor retinaculum. The carpal tunnel contains tendons and the median nerve. This nerve is responsible for sensation and movement in the ball of the thumb and some parts of the hand. If the tissue inside the carpal tunnel swells up, it can put pressure on the median nerve, which is what causes carpal tunnel syndrome. The symptoms often go away on their own, but they can sometimes last for quite a long time. There are a number of different treatments that can provide relief.

Wikipedia : 76 Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels... more...

Description from OMIM: 115430

Related Diseases for Carpal Tunnel Syndrome

Diseases related to Carpal Tunnel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 32.3 PMP22 PSMD9 SH3TC2 TTR
2 hereditary amyloidosis 30.7 B2M TTR
3 mononeuropathy 30.4 PMP22 SH3TC2 TAC1
4 burns 30.4 IL1B TTR
5 epicondylitis 30.4 COL5A1 TAC1
6 prostatitis 30.1 IL1B IL6 TGFB1
7 dupuytren contracture 30.0 IL1B TGFB1 VEGFA
8 peritonitis 29.5 B2M IL1B IL6
9 complex regional pain syndrome 29.2 IL1B IL6 TAC1
10 rheumatoid arthritis 28.6 IL1B IL6 TGFB1 TTR VEGFA
11 osteoarthritis 28.4 ACAN IL1B IL6 TGFB1
12 mononeuropathy of the median nerve, mild 12.3
13 overuse syndrome 11.4
14 acromegaly 11.4
15 paresthesia 11.4
16 repetitive motion disorders 11.4
17 macrodactyly of the hand 11.4
18 repetitive stress injuries 11.4
19 amyloidosis, hereditary, transthyretin-related 11.2
20 lymphangioleiomyomatosis 11.1
21 carney triad 11.1
22 pinched nerve 11.0
23 cerebritis 11.0
24 neuroblastoma 11.0
25 aspergillosis 11.0
26 hydrocephalus 10.9
27 histoplasmosis 10.9
28 adrenocortical carcinoma, hereditary 10.9
29 cauda equina syndrome 10.9
30 swyer-james syndrome 10.9
31 pulmonary coin lesion 10.9
32 pudendal neuralgia 10.9
33 cherubism 10.9
34 hydrocephalus, normal-pressure 10.9
35 brain cancer 10.9
36 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 10.9
37 primary pigmented nodular adrenocortical disease 10.9
38 sialadenitis 10.9
39 bile duct carcinoma 10.9
40 median arcuate ligament syndrome 10.9
41 mounier-kuhn syndrome 10.9
42 subcortical arteriosclerotic encephalopathy 10.9
43 birt-hogg-dube syndrome 10.9
44 amyotrophy, monomelic 10.9
45 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.9
46 infantile myofibromatosis 10.9
47 eastern equine encephalitis 10.9
48 papilledema 10.9
49 olivopontocerebellar atrophy 10.9
50 vascular dementia 10.9

Graphical network of the top 20 diseases related to Carpal Tunnel Syndrome:



Diseases related to Carpal Tunnel Syndrome

Symptoms & Phenotypes for Carpal Tunnel Syndrome

Symptoms via clinical synopsis from OMIM:

57
Neuro:
constrictive median neuropathy
tunnel sign

Misc:
responsive to pyridoxine administration
early onset age

Limbs:
thickened transverse carpal ligament
digital flexor tenosynovitis

Lab:
vitamin b6 deficiency


Clinical features from OMIM:

115430

Human phenotypes related to Carpal Tunnel Syndrome:

32
# Description HPO Frequency HPO Source Accession
1 vitamin b6 deficiency 32 HP:0008326
2 peripheral neuropathy 32 HP:0009830
3 constrictive median neuropathy 32 HP:0012185
4 digital flexor tenosynovitis 32 HP:0012276

UMLS symptoms related to Carpal Tunnel Syndrome:


back pain, headache, muscle cramp, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Carpal Tunnel Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 B2M COL5A1 CTGF IL1B IL6 SH3TC2
2 homeostasis/metabolism MP:0005376 10.07 PMP22 SH3TC2 TGFB1 TTR VEGFA B2M
3 growth/size/body region MP:0005378 10.06 IL1B IL6 PMP22 TGFB1 VEGFA B2M
4 integument MP:0010771 9.97 COL5A1 CTGF IL1B IL6 TAC1 TGFB1
5 mortality/aging MP:0010768 9.96 B2M BGN COL5A1 CTGF IL1B IL6
6 muscle MP:0005369 9.63 BGN IL6 PMP22 SH3TC2 TGFB1 VEGFA
7 skeleton MP:0005390 9.5 BGN CTGF IL1B IL6 SH3TC2 TGFB1
8 vision/eye MP:0005391 9.17 COL5A1 CTGF IL6 PMP22 TGFB1 TTR

Drugs & Therapeutics for Carpal Tunnel Syndrome

PubMedHealth treatment related to Carpal Tunnel Syndrome: 63

Mild to moderate carpal tunnel syndrome can usually be treated with a splint at first. The splint is worn at night to prevent the wrist from bending too far. Doctors may also advise you to avoid activities thought to be related to this condition.Injecting corticosteroids into the carpal tunnel can provide temporary relief, but corticosteroid injections aren't an effective long-term solution.Surgery may also be considered as a treatment. During the operation, the flexor retinaculum that arches across the base of the hand is cut: to reduce pressure on the median nerve. This procedure can make the symptoms go away for good, but it's not always necessary. Other treatments are usually preferred, especially in early stages of the condition. Immediate surgery is only needed in very rare cases of acute carpal tunnel syndrome.Other treatments such as acupuncture, ultrasound therapy, laser therapy or magnetic field therapy may also be recommended. But there is no evidence that they are effective in the treatment of carpal tunnel syndrome.Many people take painkillers to relieve their symptoms – particularly non-steroidal anti-inflammatory drugs (NSAIDs), which are available over-the-counter at pharmacies and drugstores. Taking vitamin B6 products is sometimes also recommended to strengthen the nerves. So far, though, research suggests that neither NSAIDs nor vitamin B6 can provide enough pain relief.

Drugs for Carpal Tunnel Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 157)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 137-58-6 3676
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
4
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
5
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
6
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
7
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
8
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
9
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
10
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3 56-12-2 119
11
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
12
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
13
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
14
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
15
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
16
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
17
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
20 tannic acid Approved, Nutraceutical Phase 4
21 Antiemetics Phase 4,Phase 2,Phase 3,Not Applicable
22 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
24 Autonomic Agents Phase 4,Phase 2,Phase 3,Not Applicable
25 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
26 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
27 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Methylprednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
31 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3,Not Applicable
32 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
35 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3,Not Applicable
36 Prednisolone phosphate Phase 4,Phase 2,Phase 3,Not Applicable
37 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
42 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
43 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Anticonvulsants Phase 4,Phase 3,Not Applicable
47 Antimanic Agents Phase 4,Phase 3,Not Applicable
48 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
50 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 190)
# Name Status NCT ID Phase Drugs
1 Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
2 Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome Completed NCT02140632 Phase 4
3 Length of Post Operative Dressing After Carpal Tunnel Release Completed NCT01310218 Phase 4
4 Postoperative Alpha Lipoic Acid in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
5 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome Completed NCT00277563 Phase 4
6 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
7 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
8 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
9 Distribution Circumferential Versus Non Circumferential of Mepivacaine in the Median and Ulnar Nerves Completed NCT01603680 Phase 4
10 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
11 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
12 Narcotic vs. Non-narcotic Pain Study Protocol Recruiting NCT01974609 Phase 4 Narcotic;non-narcotic
13 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration Active, not recruiting NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
14 Injection Versus Splinting in Carpal Tunnel Syndrome Active, not recruiting NCT02038452 Phase 4 Depo-Medrone
15 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery Enrolling by invitation NCT02029235 Phase 4 Acetaminophen/Hydrocodone;Acetaminophen/Ibuprofen
16 Preoperative Antibiotics for Carpal Tunnel Release Surgery Not yet recruiting NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
17 Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
18 Carpal Tunnel Syndrome Release Using PSU Retractor Unknown status NCT01017471 Phase 3
19 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
20 Gabapentin for Carpal Tunnel Syndrome Completed NCT00137735 Phase 3 Gabapentin
21 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
22 Steroid Injection Treatment of Carpal Tunnel Syndrome Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
23 Preoperative Gabapentine for Carpal Tunnel Completed NCT01632215 Phase 3 Gabapentine
24 Efficacy/Safety of Octreotide Acetate in Patients With Uncontrolled Acromegaly Completed NCT00372697 Phase 3 Octreotide acetate 30 mg suspension
25 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Not yet recruiting NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
26 Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
27 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
28 A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
29 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
30 Carpal Tunnel Syndrome Treated With 830nm Diode Laser Unknown status NCT00514462 Phase 1, Phase 2
31 A Pilot Study to Evaluate the Effectiveness of Ultrasound Guided Looped Thread Carpal Tunnel Release Completed NCT03476486 Phase 2
32 Fascial Manipulation on the Treatment of Carpal Tunnel Syndrome Completed NCT02495298 Phase 2
33 Alpha Lipoic Acid on Clinical and Electrophysiological Recovery in Carpal Tunnel Syndrome Undergoing Surgical Release Completed NCT02382328 Phase 2 alpha lipoic acid;Placebo
34 Percutaneous Treatment of Carpal Tunnel Syndrome With Scan Completed NCT02514317 Phase 2
35 The Treatment of the Median Nerve for the Elimination of the Symptoms Associated With the Carpal Tunnel Syndrome Completed NCT00634738 Phase 1, Phase 2
36 Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome Completed NCT00991068 Phase 2 Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch
37 Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome Completed NCT01093209 Phase 2
38 Treatment Efficacy of OMT for Carpal Tunnel Syndrome Completed NCT00394043 Phase 2
39 BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome Completed NCT02070302 Phase 2 Botulinum Toxin Type A;Placebo
40 The Treatment of Carpal Tunnel Syndrome Using Thumb Pressure Along the Median Nerve Completed NCT00634699 Phase 1, Phase 2
41 Acupuncture for Carpal Tunnel Syndrome Completed NCT00000394 Phase 2
42 Mechanisms of Neural Mobilization in the Treatment of Chronic Pain Completed NCT00929123 Phase 1, Phase 2
43 Acute Human Study: StimRouter for Peripheral Nerve Stimulation of Discrete Peripheral Nerves Completed NCT00665132 Phase 1, Phase 2
44 Minocycline to Reduce Pain After Carpal Tunnel Release Completed NCT02051296 Phase 2 Minocycline;placebo
45 Sham Device, Pill Placebo or Treatment For Arm Pain Completed NCT00029497 Phase 2 Amitriptyline
46 Effect of Kinesiotaping for the Treatment of Hormone-induced Myalgia in Women Given Breast Cancer Survivors Completed NCT02406794 Phase 1, Phase 2 Neuromuscular taping
47 Influence of Pronator Teres Release on Treatment of Median Nerve Compression Neuropathy Recruiting NCT01562860 Phase 2
48 Botulinum Toxin for Carpal Tunnel Syndrome Active, not recruiting NCT00701233 Phase 2 Botulinum toxin;Corticosteroid injection into Carpal Tunnel
49 Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Not yet recruiting NCT03111186 Phase 2 Oxycodone Hcl 5Mg;Ibuprofen 400 mg;Acetaminophen 650 mg
50 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2

Search NIH Clinical Center for Carpal Tunnel Syndrome

Cochrane evidence based reviews: carpal tunnel syndrome

Genetic Tests for Carpal Tunnel Syndrome

Genetic tests related to Carpal Tunnel Syndrome:

# Genetic test Affiliating Genes
1 Carpal Tunnel Syndrome 29 TTR

Anatomical Context for Carpal Tunnel Syndrome

MalaCards organs/tissues related to Carpal Tunnel Syndrome:

41
Testes, Bone, Thyroid, Skin, Breast, Brain, Heart

Publications for Carpal Tunnel Syndrome

Articles related to Carpal Tunnel Syndrome:

(show top 50) (show all 1053)
# Title Authors Year
1
AAOS Appropriate Use Criteria: Management of Carpal Tunnel Syndrome. ( 29432365 )
2018
2
Carpal tunnel syndrome prevalence: an evaluation of workers at a raw poultry processing plant. ( 29873286 )
2018
3
Occurrence of bifid median nerve in healthy and carpal tunnel syndrome patients. ( 29413456 )
2018
4
HOW DO BOARD-CERTIFIED HAND SURGEONS MANAGE CARPAL TUNNEL SYNDROME? A NATIONAL SURVEY. ( 29977145 )
2018
5
A prognostic model for the patient reported outcome of surgical treatment of carpal tunnel syndrome. ( 29981160 )
2018
6
Diagnosis and Treatment of Carpal Tunnel Syndrome in Low-prevalence Circumstances. ( 29952784 )
2018
7
Topiramate-induced Neuropathy Mimicking Carpal Tunnel Syndrome: A Case Report. ( 29430500 )
2018
8
What types of treatment are provided for patients with Carpal Tunnel Syndrome? A retrospective analysis of commercial insurance. ( 29452295 )
2018
9
Management of Carpal Tunnel Syndrome. ( 29420323 )
2018
10
Ultrasonography for the Diagnosis of Carpal Tunnel Syndrome in Diabetic Patients: Missing the Mark? ( 29966141 )
2018
11
Are Carpal Tunnel Syndrome and Regional Degenerative Osteoarthritis Linked? Results of a Case-Control Study. ( 29409410 )
2018
12
Effect of Alpha-Lipoic Acid on Clinical and Neurophysiologic Recovery of Carpal Tunnel Syndrome: A Double-Blind, Randomized Clinical Trial. ( 29356576 )
2018
13
Intrasynovial spindle cell lipoma of the deep flexor of the middle finger causing intermittent carpal tunnel syndrome-case report and review of the literature. ( 29429014 )
2018
14
Median nerve ultrasound in carpal tunnel syndrome with normal electrodiagnostic tests. ( 29949031 )
2018
15
Comparison of splinting and Kinesio taping in the treatment of carpal tunnel syndrome: a prospective randomized study. ( 29948355 )
2018
16
Bilateral carpal tunnel syndrome - A review. ( 28992938 )
2018
17
Carpal tunnel syndrome after an electrical injury: a case report and review of literature. ( 29899196 )
2018
18
Ultrasound carpal tunnel syndrome: additional criteria for diagnosis. ( 28859853 )
2018
19
Effect of Polydeoxyribonucleotide Injection in a Patient with Carpal Tunnel Syndrome: A Case Report. ( 29373371 )
2018
20
Carpal Tunnel Syndrome: Evaluation of the Effects of Low-Level Laser Therapy With Ultrasound Strain Imaging. ( 29892976 )
2018
21
A Prospective Comparison of Diagnostic Tools for the Diagnosis of Carpal Tunnel Syndrome. ( 29935774 )
2018
22
Sonographic assessment of carpal tunnel syndrome in diabetic patients with and without polyneuropathy. ( 29901629 )
2018
23
Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: a prospective randomized controlled trial. ( 29370788 )
2018
24
Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trial. ( 29433485 )
2018
25
Translation and Validation of the Persian Version the Boston Carpal Tunnel Syndrome Questionnaire. ( 29430499 )
2018
26
Diffusion tensor imaging findings of the median nerve before and after carpal tunnel corticosteroid injection in patients with carpal tunnel syndrome: a preliminary study. ( 29979105 )
2018
27
Author Correction to: L-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome: Effects on Nerve Protection, Hand Function and Pain. ( 29441455 )
2018
28
Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records. ( 29921681 )
2018
29
Thumb Opposition Recovery Following Surgery for Severe Carpal Tunnel Syndrome: A Clinical, Radiological, and Electrophysiological Pilot Study. ( 29934085 )
2018
30
Short-term clinical outcome of orthosis alone vs combination of orthosis, nerve, and tendon gliding exercises and ultrasound therapy for treatment of carpal tunnel syndrome. ( 29426574 )
2018
31
The effectiveness of splinting and surgery on sleep disturbance in carpal tunnel syndrome. ( 28872412 )
2018
32
Diagnosis of carpal tunnel syndrome. ( 29894306 )
2018
33
A Median Nerve Anterior Transposition Procedure for Multi-Recurrent Hemodialysis-Related Carpal Tunnel Syndrome. ( 29409425 )
2018
34
Effectiveness of ultrasound-guided vs direct approach corticosteroid injections for carpal tunnel syndrome: A double-blind randomized controlled trial. ( 29355292 )
2018
35
Mental and Physical Health Disparities in Patients With Carpal Tunnel Syndrome Living With High Levels of Social Deprivation. ( 29945843 )
2018
36
Different doses of steroid injection in elderly patients with carpal tunnel syndrome: a triple-blind, randomized, controlled trial. ( 29403268 )
2018
37
Efficacy of dietary supplement with nutraceutical composed combined with extremely-low-frequency electromagnetic fields in carpal tunnel syndrome. ( 29950763 )
2018
38
Predicting Clinical Outcome After Surgical Treatment inA Patients With Carpal Tunnel Syndrome. ( 29945840 )
2018
39
The role of electrophysiological examination in the diagnosis of carpal tunnel syndrome: Analysis of 2516 patients. ( 29888720 )
2018
40
Blocking fibrotic signaling in fibroblasts from patients with carpal tunnel syndrome. ( 28294324 )
2018
41
Evidence-Based Medicine: Current Evidence in the Diagnosis and Management of Carpal Tunnel Syndrome. ( 28654613 )
2017
42
Effectiveness of Lavendula stoechas essential oil in treatment of mild to moderate carpal tunnel syndrome: A randomized controlled trial. ( 28803691 )
2017
43
A repeated carpal tunnel syndrome due to tophaceous gout in flexor tendon: A case report. ( 28248892 )
2017
44
The Incidence of Complex Regional Pain Syndrome in Simultaneous Surgical Treatment of Carpal Tunnel Syndrome and Dupuytren Contracture. ( 28691512 )
2017
45
The comparison between effectiveness of ultrasound guided corticosteroid injection above versus below the median nerve in mild to moderate carpal tunnel syndrome: A randomized controlled trial. ( 29232214 )
2017
46
Teaching NeuroImages: Sonographic detection of intraneural perineurioma in therapy-refractory carpal tunnel syndrome. ( 28265045 )
2017
47
Plexiform neurofibroma as a cause of carpal tunnel syndrome in a radial deficiency patient. ( 28554231 )
2017
48
Treatment of mild to moderate carpal tunnel syndrome in patients with diabetic neuropathy using low level laser therapy versus ultrasound controlled comparative study. ( 28856107 )
2017
49
Bifid median nerve and carpal tunnel syndrome: an uncommon anatomical variation. ( 28447963 )
2017
50
Carpal Tunnel Syndrome and Trigger Wrist Caused by Localized Amyloidosis: A Case Report. ( 29117820 )
2017

Variations for Carpal Tunnel Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Carpal Tunnel Syndrome:

75
# Symbol AA change Variation ID SNP ID
1 TTR p.Tyr134His VAR_007598 rs121918088

ClinVar genetic disease variations for Carpal Tunnel Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh37 Chromosome 18, 29178618: 29178618
2 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh38 Chromosome 18, 31598655: 31598655
3 TTR NM_000371.3(TTR): c.400T> C (p.Tyr134His) single nucleotide variant Pathogenic rs121918088 GRCh37 Chromosome 18, 29178594: 29178594
4 TTR NM_000371.3(TTR): c.400T> C (p.Tyr134His) single nucleotide variant Pathogenic rs121918088 GRCh38 Chromosome 18, 31598631: 31598631

Expression for Carpal Tunnel Syndrome

Search GEO for disease gene expression data for Carpal Tunnel Syndrome.

Pathways for Carpal Tunnel Syndrome

Pathways related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 B2M IL1B IL6 PSMD9 TGFB1 VEGFA
2
Show member pathways
12.88 ACAN COL5A1 CTGF IL6 TGFB1
3
Show member pathways
12.62 B2M COL5A1 IL1B IL6 TGFB1 VEGFA
4
Show member pathways
12.56 ACAN BGN COL5A1 TGFB1 TTR
5
Show member pathways
12.53 CTGF IL1B IL6 TGFB1
6 11.95 IL1B IL6 TAC1 VEGFA
7
Show member pathways
11.91 CTGF IL1B IL6 TGFB1
8 11.9 IL6 TGFB1 VEGFA
9 11.78 IL1B IL6 TGFB1
10 11.73 IL1B IL6 TGFB1
11 11.7 ACAN IL1B IL6 TGFB1
12 11.61 IL1B IL6 TGFB1 VEGFA
13 11.6 IL1B IL6 TGFB1
14 11.54 ACAN TGFB1 VEGFA
15
Show member pathways
11.51 IL1B IL6 VEGFA
16 11.46 ACAN BGN TGFB1
17 11.45 IL1B IL6 TGFB1 VEGFA
18 11.38 IL6 TGFB1 VEGFA
19 11.34 IL1B IL6 TGFB1
20 11.31 IL6 TGFB1 VEGFA
21 11.21 IL1B IL6 TGFB1 VEGFA
22 11.02 IL1B IL6 TGFB1
23 10.72 CTGF IL1B IL6 TGFB1

GO Terms for Carpal Tunnel Syndrome

Cellular components related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 B2M BGN COL5A1 CTGF IL1B IL6
2 Golgi lumen GO:0005796 9.5 ACAN BGN TGFB1
3 extracellular matrix GO:0031012 9.46 ACAN BGN COL5A1 TGFB1
4 secretory granule GO:0030141 9.43 IL1B TGFB1 VEGFA
5 extracellular region GO:0005576 9.36 ACAN B2M BGN COL5A1 CTGF IL1B

Biological processes related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.86 IL1B IL6 PMP22 TGFB1
2 inflammatory response GO:0006954 9.84 IL1B IL6 TAC1 TGFB1
3 positive regulation of cell proliferation GO:0008284 9.8 CTGF IL1B IL6 TGFB1 VEGFA
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 IL1B IL6 TGFB1
5 extracellular matrix organization GO:0030198 9.67 ACAN BGN COL5A1 TTR
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 IL6 TGFB1 VEGFA
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.61 IL6 TGFB1 VEGFA
8 positive regulation of collagen biosynthetic process GO:0032967 9.58 CTGF TGFB1
9 positive regulation of protein complex assembly GO:0031334 9.57 TGFB1 VEGFA
10 positive regulation of protein phosphorylation GO:0001934 9.56 CTGF IL1B TGFB1 VEGFA
11 positive regulation of gene expression GO:0010628 9.55 CTGF IL1B IL6 TGFB1 VEGFA
12 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.52 TGFB1 VEGFA
13 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.51 IL1B VEGFA
14 positive regulation of cell division GO:0051781 9.5 IL1B TGFB1 VEGFA
15 positive regulation of histone acetylation GO:0035066 9.49 IL1B TGFB1
16 positive regulation of acute inflammatory response GO:0002675 9.48 IL6 TAC1
17 cytokine-mediated signaling pathway GO:0019221 9.35 BGN IL1B IL6 TGFB1 VEGFA
18 regulation of signaling receptor activity GO:0010469 9.1 CTGF IL1B IL6 TGFB1 TTR VEGFA

Molecular functions related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.5 COL5A1 CTGF VEGFA
2 integrin binding GO:0005178 9.43 COL5A1 CTGF IL1B
3 extracellular matrix structural constituent GO:0005201 9.33 ACAN BGN COL5A1
4 cytokine activity GO:0005125 9.26 IL1B IL6 TGFB1 VEGFA
5 growth factor activity GO:0008083 8.92 CTGF IL6 TGFB1 VEGFA

Sources for Carpal Tunnel Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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