CTS1
MCID: CRP001
MIFTS: 72

Carpal Tunnel Syndrome (CTS1)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Carpal Tunnel Syndrome

MalaCards integrated aliases for Carpal Tunnel Syndrome:

Name: Carpal Tunnel Syndrome 58 12 77 26 55 30 56 6 44 45 15 17 74 3 64
Carpal Tunnel Syndrome, Familial 58 13 6 41 74
Cts 58 26 76 17 3
Amyotrophy, Thenar, of Carpal Origin 58 26
Cts1 58 76
Compression Neuropathy, Carpal Tunnel 26
Entrapment Neuropathy, Carpal Tunnel 26
Thenar Amyotrophy of Crapal Origin 76
Median Neuropathy, Carpal Tunnel 26
Carpal Tunnel Median Neuropathy 12
Distal Median Nerve Compression 26
Median Neuropathy Carpal Tunnel 76
Familial Carpal Tunnel Syndrome 38
Distal Median Nerve Entrapment 26
Cts - Carpal Tunnel Syndrome 12
Carpal Tunnel Syndrome 1 76
Median Nerve Entrapment 12
Carpal Tunnel 26
Carpal Canal 26

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
carpal tunnel syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:12169
OMIM 58 115430
KEGG 38 H00798
ICD9CM 36 354.0
MeSH 45 D002349
NCIt 51 C34450
SNOMED-CT 69 57406009
ICD10 34 G56.0 G56.00
MedGen 43 C0007286

Summaries for Carpal Tunnel Syndrome

MedlinePlus : 44 You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. Suddenly, a sharp, piercing pain shoots through the wrist and up your arm. Just a passing cramp? It could be carpal tunnel syndrome. The carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. It contains nerve and tendons. Sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. Symptoms usually start gradually. As they worsen, grasping objects can become difficult. Often, the cause is having a smaller carpal tunnel than other people do. Other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. Women are three times more likely to have carpal tunnel syndrome than men. Early diagnosis and treatment are important to prevent permanent nerve damage. Your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. Treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Carpal Tunnel Syndrome, also known as carpal tunnel syndrome, familial, is related to peripheral nervous system disease and epicondylitis, and has symptoms including seizures, tremor and back pain. An important gene associated with Carpal Tunnel Syndrome is TTR (Transthyretin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin, and related phenotypes are peripheral neuropathy and constrictive median neuropathy

Genetics Home Reference : 26 Carpal tunnel syndrome is a disorder caused by disturbances in nerve function (neuropathy), leading to pain and numbness or tingling (paresthesia) primarily in the wrist and hand. While carpal tunnel syndrome can occur at any age, it most often affects people between the ages of 40 and 60. In more than half of cases, both hands are affected; however, the severity may vary between hands. When only one hand is affected, it is most often the hand used for writing (the dominant hand).

CDC : 3 The goal of ergonomics (i.e. the scientific study of people at work) is to prevent soft tissue injuries and musculoskeletal disorders (MSDs) caused by sudden or sustained exposure to force, vibration, repetitive motion, and awkward posture. To create an ergonomically sound work environment, NIOSH ergonomists and industrial hygienists recommend designing tasks, work spaces, controls, displays, tools, lighting, and equipment to fit employee’s physical capabilities and limitations. On this page you will find the Musculoskeletal Health Program’s ergonomic recommendations and musculoskeletal health-related research.

NINDS : 55 Carpal tunnel syndrome (CTS) occurs when  the median nerve, which runs from the forearm into the palm of the hand,  becomes pressed or squeezed at the wrist. The carpal tunnel is a narrow, rigid passageway of ligament and bones at the base of the hand that houses the median nerve and the tendons that bend the fingers. The median nerve provides feeling to the palm side of the thumb and to most of the fingers. Symptoms usually start gradually, with numbness, tingling, weakness, and sometimes pain in the hand and wrist.  CTS makes it difficult for some people to drive, read a book, grasp small objects, or do other tasks. Sometimes no direct cause of CTS can be found; contributing factors include trauma or injury to the wrist that causes swelling, as well as thyroid disease, rheumatoid arthritis, and fluid retention during pregnancy. Women are three times more likely than men to develop carpal tunnel syndrome. The disorder usually occurs only in adults.

UniProtKB/Swiss-Prot : 76 Carpal tunnel syndrome 1: A condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.

PubMed Health : 64 About carpal tunnel syndrome: Most people's hands briefly "fall asleep" every now and then. They then feel numb or tingly. Although this is a little unpleasant, it's usually over very quickly. Carpal tunnel syndrome has similar symptoms – but they keep coming back again and are often painful.The carpal tunnel is a passageway inside of the wrist that is surrounded by bones and connective tissue. It runs along the inner side of the wrist to the base of the hand and is covered by a strong, fibrous band made up of connective tissue, called the flexor retinaculum. The carpal tunnel contains tendons and the median nerve. This nerve is responsible for sensation and movement in the ball of the thumb and some parts of the hand. If the tissue inside the carpal tunnel swells up, it can put pressure on the median nerve, which is what causes carpal tunnel syndrome. The symptoms often go away on their own, but they can sometimes last for quite a long time. There are a number of different treatments that can provide relief.

Wikipedia : 77 Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels... more...

Description from OMIM: 115430

Related Diseases for Carpal Tunnel Syndrome

Diseases related to Carpal Tunnel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2474)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 30.7 TTR TAC1 SH3TC2 PSMD9 PMP22 INS
2 epicondylitis 30.6 COL5A1 TAC1
3 mononeuropathy 30.5 TAC1 SH3TC2 PMP22
4 hereditary amyloidosis 30.4 TTR B2M
5 osteoarthritis 30.2 TGFB1 IL6 IL1B
6 nerve compression syndrome 30.2 TTR PSMD9 COL5A1 B2M
7 diabetic neuropathy 30.0 INS PMP22 VEGFA
8 dupuytren contracture 30.0 VEGFA TGFB1 IL1B
9 rheumatoid arthritis 30.0 IL1B IL6 TGFB1 TTR VEGFA
10 interstitial lung disease 29.9 IL1B IL6 TGFB1
11 complex regional pain syndrome 29.9 TAC1 IL6 IL1B
12 burns 29.8 TTR INS IL1B
13 extramedullary plasmacytoma 29.7 B2M IL6
14 peritonitis 29.7 B2M IL1B IL6
15 osteonecrosis of the jaw 29.7 TGFB1 VEGFA
16 al amyloidosis 29.7 B2M TTR
17 brain edema 29.5 IL1B IL6 VEGFA
18 pneumoconiosis 29.4 TGFB1 IL6 IL1B
19 prostatitis 29.4 TGFB1 IL6 IL1B
20 spinal disease 29.4 VEGFA IL6
21 arteries, anomalies of 29.3 VEGFA INS IL6 IL1B
22 sleep apnea 29.3 IL1B IL6 INS
23 acquired immunodeficiency syndrome 29.3 B2M IL1B IL6
24 esophagitis 29.3 IL1B IL6 TGFB1
25 poems syndrome 29.3 VEGFA IL6 IL1B
26 endometriosis 29.3 IL1B IL6 VEGFA
27 bone disease 29.2 B2M IL1B IL6
28 amyloid tumor 29.2 TTR B2M
29 periapical periodontitis 29.2 IL1B IL6
30 meningoencephalitis 29.1 TAC1 IL6 B2M
31 diabetes mellitus, insulin-dependent 29.1 INS IL6 IL1B
32 kidney disease 29.1 TTR TGFB1 INS IL6 B2M
33 tendinopathy 29.1 COL5A1 VEGFA
34 fatty liver disease 29.0 IL1B IL6 INS
35 critical limb ischemia 29.0 IL6 VEGFA
36 primary effusion lymphoma 28.9 IL6 VEGFA
37 intestinal disease 28.8 IL1B IL6 VEGFA
38 chagas disease 28.6 IL1B IL6 TGFB1
39 cytomegalovirus infection 28.6 B2M IL1B IL6
40 large intestine cancer 28.6 IL1B IL6 INS VEGFA
41 viral encephalitis 28.6 VEGFA IL6 IL1B
42 central nervous system disease 28.6 TTR IL6 IL1B
43 ewing sarcoma 28.6 IL1B IL6 INS TGFB1 VEGFA
44 bronchial disease 28.4 IL1B IL6 TAC1
45 chronic kidney failure 28.3 TTR TGFB1 INS IL6 B2M
46 autoimmune disease 28.0 IL1B IL6 INS
47 nervous system disease 27.7 VEGFA TTR INS IL6 IL1B
48 mononeuropathy of the median nerve, mild 12.5
49 colobomatous microphthalmia 11.6
50 acromegaly 11.6

Graphical network of the top 20 diseases related to Carpal Tunnel Syndrome:



Diseases related to Carpal Tunnel Syndrome

Symptoms & Phenotypes for Carpal Tunnel Syndrome

Human phenotypes related to Carpal Tunnel Syndrome:

33
# Description HPO Frequency HPO Source Accession
1 peripheral neuropathy 33 HP:0009830
2 constrictive median neuropathy 33 HP:0012185
3 digital flexor tenosynovitis 33 HP:0012276
4 vitamin b6 deficiency 33 HP:0008326

Symptoms via clinical synopsis from OMIM:

58
Neuro:
constrictive median neuropathy
tunnel sign

Misc:
responsive to pyridoxine administration
early onset age

Limbs:
thickened transverse carpal ligament
digital flexor tenosynovitis

Lab:
vitamin b6 deficiency

Clinical features from OMIM:

115430

UMLS symptoms related to Carpal Tunnel Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, muscle cramp

MGI Mouse Phenotypes related to Carpal Tunnel Syndrome:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 B2M COL5A1 IL1B IL6 INS SH3TC2
2 homeostasis/metabolism MP:0005376 10.13 B2M BGN IL1B IL6 INS PMP22
3 behavior/neurological MP:0005386 10.11 BGN IL6 INS PMP22 SH3TC2 TAC1
4 growth/size/body region MP:0005378 10.11 B2M BGN COL5A1 IL1B IL6 INS
5 mortality/aging MP:0010768 10.07 B2M BGN COL5A1 IL1B IL6 INS
6 integument MP:0010771 10.06 B2M BGN COL5A1 IL1B IL6 INS
7 digestive/alimentary MP:0005381 9.95 B2M IL6 INS TGFB1 TTR VEGFA
8 muscle MP:0005369 9.87 BGN IL6 INS PMP22 SH3TC2 TGFB1
9 renal/urinary system MP:0005367 9.73 IL6 INS TAC1 TGFB1 TTR VEGFA
10 reproductive system MP:0005389 9.7 B2M BGN IL6 INS PMP22 TGFB1
11 skeleton MP:0005390 9.5 BGN IL1B IL6 INS SH3TC2 TGFB1
12 vision/eye MP:0005391 9.17 COL5A1 IL6 INS PMP22 TGFB1 TTR

Drugs & Therapeutics for Carpal Tunnel Syndrome

PubMedHealth treatment related to Carpal Tunnel Syndrome: 64

Mild to moderate carpal tunnel syndrome can usually be treated with a splint at first. The splint is worn at night to prevent the wrist from bending too far. Doctors may also advise you to avoid activities thought to be related to this condition.Injecting corticosteroids into the carpal tunnel can provide temporary relief, but corticosteroid injections aren't an effective long-term solution.Surgery may also be considered as a treatment. During the operation, the flexor retinaculum that arches across the base of the hand is cut: to reduce pressure on the median nerve. This procedure can make the symptoms go away for good, but it's not always necessary. Other treatments are usually preferred, especially in early stages of the condition. Immediate surgery is only needed in very rare cases of acute carpal tunnel syndrome.Other treatments such as acupuncture, ultrasound therapy, laser therapy or magnetic field therapy may also be recommended. But there is no evidence that they are effective in the treatment of carpal tunnel syndrome.Many people take painkillers to relieve their symptoms – particularly non-steroidal anti-inflammatory drugs (NSAIDs), which are available over-the-counter at pharmacies and drugstores. Taking vitamin B6 products is sometimes also recommended to strengthen the nerves. So far, though, research suggests that neither NSAIDs nor vitamin B6 can provide enough pain relief.

Drugs for Carpal Tunnel Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 184)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 302-25-0
2
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 50-24-8 5755
3
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 2921-57-5
6
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
7
Bupivacaine Approved, Investigational Phase 4,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
8
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
9
tannic acid Approved Phase 4 1401-55-4
10
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
11
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
12
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
13
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
14
Cefazolin Approved Phase 4 25953-19-9 656510 33255
15
Vancomycin Approved Phase 4 1404-90-6 441141 14969
16
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
17
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
18
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
19
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
20
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
21
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
22
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
23
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
24
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
25
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-30-3 6037
27
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 2920-86-7
28 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
29 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
31 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Autonomic Agents Phase 4,Phase 2,Phase 3,Not Applicable
33 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
34 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Antiemetics Phase 4,Phase 2,Phase 3,Not Applicable
36 Methylprednisolone Acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
37 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
38 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
39 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Respiratory System Agents Phase 4,Phase 3,Not Applicable
44 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
45 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
48 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Epinephryl borate Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 224)
# Name Status NCT ID Phase Drugs
1 Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
2 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration Active, not recruiting NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
3 Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome Completed NCT02140632 Phase 4
4 Length of Post Operative Dressing After Carpal Tunnel Release Completed NCT01310218 Phase 4
5 Injection Versus Splinting in Carpal Tunnel Syndrome Active, not recruiting NCT02038452 Phase 4 Depo-Medrone
6 Exparel and Education to Avoid Opioids After Carpal Tunnel Release Recruiting NCT03867539 Phase 4
7 Preoperative Antibiotics for Carpal Tunnel Release Surgery Not yet recruiting NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
8 Comparison of the Efficacy of Corticosteroid Injection and ESWT in Patients With CTS Not yet recruiting NCT03792945 Phase 4 local injection
9 Postoperative Alpha Lipoic Acid in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
10 Myofascial Release on Electrophysiological Measures of Pregnant Women With CTS Completed NCT03802448 Phase 4
11 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome Completed NCT00277563 Phase 4
12 Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
13 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
14 Narcotic vs. Non-narcotic Pain Study Protocol Recruiting NCT01974609 Phase 4 Narcotic;non-narcotic
15 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
16 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
17 Onset and Duration of Forearm Nerve Blockade Completed NCT03649763 Phase 4 Lidocaine;Bupivacaine;Lidocaine
18 Distribution Circumferential Versus Non Circumferential of Mepivacaine in the Median and Ulnar Nerves Completed NCT01603680 Phase 4
19 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
20 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery Terminated NCT02029235 Phase 4 Acetaminophen/Ibuprofen;Acetaminophen/Hydrocodone
21 Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture Recruiting NCT03749616 Phase 4 Ibuprofen;Acetaminophen
22 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
23 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Unknown status NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
24 Carpal Tunnel Syndrome Release Using PSU Retractor Unknown status NCT01017471 Phase 3
25 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
26 Gabapentin for Carpal Tunnel Syndrome Completed NCT00137735 Phase 3 Gabapentin
27 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
28 Steroid Injection Treatment of Carpal Tunnel Syndrome Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
29 Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
30 Preoperative Gabapentine for Carpal Tunnel Completed NCT01632215 Phase 3 Gabapentine
31 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
32 A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
33 Efficacy/Safety of Octreotide Acetate in Patients With Uncontrolled Acromegaly Completed NCT00372697 Phase 3 Octreotide acetate 30 mg suspension
34 Assessment of 18F-Florbetaben Whole-body PET for the Detection of Cardiac and Extracardiac Sites of Amyloid Deposits Not yet recruiting NCT03616496 Phase 2, Phase 3 Neuraceq 300MBq/mL Solution for Injection for PET imaging
35 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
36 Carpal Tunnel Syndrome Treated With 830nm Diode Laser Unknown status NCT00514462 Phase 1, Phase 2
37 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
38 A Pilot Study to Evaluate the Effectiveness of Ultrasound Guided Looped Thread Carpal Tunnel Release Completed NCT03476486 Phase 2
39 Fascial Manipulation on the Treatment of Carpal Tunnel Syndrome Completed NCT02495298 Phase 2
40 Botulinum Toxin for Carpal Tunnel Syndrome Active, not recruiting NCT00701233 Phase 2 Botulinum toxin;Corticosteroid injection into Carpal Tunnel
41 Alpha Lipoic Acid on Clinical and Electrophysiological Recovery in Carpal Tunnel Syndrome Undergoing Surgical Release Completed NCT02382328 Phase 2 alpha lipoic acid;Placebo
42 Percutaneous Treatment of Carpal Tunnel Syndrome With Scan Completed NCT02514317 Phase 2
43 The Treatment of the Median Nerve for the Elimination of the Symptoms Associated With the Carpal Tunnel Syndrome Completed NCT00634738 Phase 1, Phase 2
44 Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome Completed NCT00991068 Phase 2 Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch
45 Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome Completed NCT01093209 Phase 2
46 Treatment Efficacy of OMT for Carpal Tunnel Syndrome Completed NCT00394043 Phase 2
47 BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome Completed NCT02070302 Phase 2 Botulinum Toxin Type A;Placebo
48 The Treatment of Carpal Tunnel Syndrome Using Thumb Pressure Along the Median Nerve Completed NCT00634699 Phase 1, Phase 2
49 Acupuncture for Carpal Tunnel Syndrome Completed NCT00000394 Phase 2
50 Mechanisms of Neural Mobilization in the Treatment of Chronic Pain Completed NCT00929123 Phase 1, Phase 2

Search NIH Clinical Center for Carpal Tunnel Syndrome

Cochrane evidence based reviews: carpal tunnel syndrome

Genetic Tests for Carpal Tunnel Syndrome

Genetic tests related to Carpal Tunnel Syndrome:

# Genetic test Affiliating Genes
1 Carpal Tunnel Syndrome 30 TTR

Anatomical Context for Carpal Tunnel Syndrome

MalaCards organs/tissues related to Carpal Tunnel Syndrome:

42
Testes, Bone, Skin, Thyroid, Breast, Brain, Heart

Publications for Carpal Tunnel Syndrome

Articles related to Carpal Tunnel Syndrome:

(show top 50) (show all 3240)
# Title Authors Year
1
Assessment of manual dysfunction in occupationally active women with carpal tunnel syndrome. ( 30860206 )
2019
2
Sleep disturbance and response to surgical decompression in patients with carpal tunnel syndrome: a prospective randomized pilot comparison of open versus endoscopic release. ( 30889160 )
2019
3
Factors determining the effectiveness of conservative treatment in patients with carpal tunnel syndrome. ( 30900696 )
2019
4
Prevalence of carpal tunnel syndrome symptoms among dentists working in Riyadh. ( 30905925 )
2019
5
The Effectiveness of Ultrasound-Guided Steroid Injection Combined with Miniscalpel-Needle Release in the Treatment of Carpal Tunnel Syndrome vs. Steroid Injection Alone: A Randomized Controlled Study. ( 30915366 )
2019
6
Nerve hydrodissection for carpal tunnel syndrome: A prospective, randomized, double-blind, controlled trial. ( 30339737 )
2019
7
Revision surgery in carpal tunnel syndrome: a retrospective study comparing the Canaletto® device alone versus a combination of Canaletto® and Dynavisc® gel. ( 30472072 )
2019
8
Cost-Effectiveness Evaluation of Manual Physical Therapy Versus Surgery for Carpal Tunnel Syndrome: Evidence From a Randomized Clinical Trial. ( 30501389 )
2019
9
Carpal tunnel syndrome due to hibernoma of the wrist: Case report. ( 30528551 )
2019
10
Correction to: Aromatase inhibitor-induced carpal tunnel syndrome: prevalence in daily practice. ( 30535957 )
2019
11
Variation in Nonsurgical Services for Carpal Tunnel Syndrome Across a Large Integrated Health Care System. ( 30579690 )
2019
12
Acetyl-L-Carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome: A Double-Blind, Randomized, Controlled Trial. ( 30589790 )
2019
13
Histopathologic Evaluation of Flexor Tenosynovium in Recurrent Carpal Tunnel Syndrome. ( 30589791 )
2019
14
The Use of Neuromuscular Ultrasound and NCS/EMG Testing in the Differential Diagnosis of Carpal Tunnel Syndrome and Radiculopathy. ( 30601727 )
2019
15
Local effects of acupuncture on the median and ulnar nerves in patients with carpal tunnel syndrome: a pilot mechanistic study protocol. ( 30611294 )
2019
16
Familial occurrence of carpal tunnel syndrome. ( 30620043 )
2019
17
Acute atraumatic carpal tunnel syndrome due to flexor tendon rupture following palmar plate osteosynthesis in a patient taking rivaroxaban. ( 30631915 )
2019
18
False-Positive Rates for Nerve Conduction Studies and Ultrasound in Patients Without Clinical Signs and Symptoms of Carpal Tunnel Syndrome. ( 30635201 )
2019
19
Role of Ultrasound to Monitor Patients With Carpal Tunnel Syndrome Treated With a Local Corticosteroid. ( 30653694 )
2019
20
Comparing Diagnostic and Treatment Recommendations of Carpal Tunnel Syndrome Available on the Internet With AAOS Clinical Practice Guidelines. ( 30654676 )
2019
21
Quantitative evaluation of hand motor function using a gyrosensor in mild and moderate carpal tunnel syndrome. ( 30677150 )
2019
22
Is manual therapy based on neurodynamic techniques effective in the treatment of carpal tunnel syndrome? A randomized controlled trial. ( 30688098 )
2019
23
"Carpal tunnel syndrome:" A bibliometric study of 35 years of research. ( 30688235 )
2019
24
Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies. ( 30688308 )
2019
25
Carpal tunnel release with versus without flexor retinaculum reconstruction for carpal tunnel syndrome at short- and long-term follow up-A meta-analysis of randomized controlled trials. ( 30689656 )
2019
26
Tendencies in the Post-surgical Approach for Carpal Tunnel Syndrome. Current Clinical Practice. ( 30691948 )
2019
27
The effects of cupping therapy as a new approach in the physiotherapeutic management of carpal tunnel syndrome. ( 30697914 )
2019
28
Unprecedented recurrence of carpal tunnel syndrome by metaplastic synovial cyst in the carpal tunnel. ( 30704837 )
2019
29
Short term effectiveness of platelet-rich plasma in carpal tunnel syndrome: A controlled study. ( 30707787 )
2019
30
A Comparative Multimetric Assessment of English and Spanish Carpal Tunnel Syndrome Materials. ( 30739070 )
2019
31
Recurrent and persistent carpal tunnel syndrome: predicting clinical outcome of revision surgery. ( 30771785 )
2019
32
Mycobacterium szulgai infection as a cause of carpal tunnel syndrome in a patient who kept a Mississippi mud turtle. ( 30786809 )
2019
33
The comparison of the effectiveness between different doses of local methylprednisolone injection versus triamcinolone in Carpal Tunnel Syndrome: a double-blind clinical trial. ( 30787634 )
2019
34
Role of Biomechanical Factors in Resolution of Carpal Tunnel Syndrome among a Population of Workers. ( 30789447 )
2019
35
Association between multiple trigger fingers, systemic diseases and carpal tunnel syndrome: A multivariate analysis. ( 30795997 )
2019
36
The controversy of the normal values of ultrasonography in carpal tunnel syndrome: diagnostic accuracy of wrist-dependent CSA revisited. ( 30796623 )
2019
37
Incidence of referred carpal tunnel syndrome and carpal tunnel release surgery in the general population: Increase over time and regional variations. ( 30798784 )
2019
38
Can ultrasound imaging be used for the diagnosis of carpal tunnel syndrome in diabetic patients? A systemic review and network meta-analysis. ( 30805796 )
2019
39
Effects of Exercise and Enzyme Therapy in Early Occupational Carpal Tunnel Syndrome: A Preliminary Study. ( 30809548 )
2019
40
Prognostic factors for response to treatment by corticosteroid injection or surgery in carpal tunnel syndrome (PaLMS study): a prospective multi-centre cohort study. ( 30815889 )
2019
41
A Comparison of PROMIS Physical Function and Pain Interference Scores in Patients With Carpal Tunnel Syndrome: Research Collection Versus Routine Clinical Collection. ( 30818982 )
2019
42
Quality of Randomized Controlled Trials for Surgical Treatment of Carpal Tunnel Syndrome: A Systematic Review. ( 30822284 )
2019
43
A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. ( 30833571 )
2019
44
Electrophysiologic severity of carpal tunnel syndrome in diabetic patients of the Saudi population. ( 30842396 )
2019
45
Optimal Ultrasonographic Measurements for Diagnosing Carpal Tunnel Syndrome in Patients With Diabetic Sensorimotor Polyneuropathy: A Case-Control Study. ( 30852870 )
2019
46
A Comparison of 6 Diagnostic Tests for Carpal Tunnel Syndrome Using Latent Class Analysis. ( 30854901 )
2019
47
Upper extremity disability is associated with pain intensity and grip strength in women with bilateral idiopathic carpal tunnel syndrome. ( 30856127 )
2019
48
A case of herpes zoster infection mimicking carpal tunnel syndrome. ( 30860133 )
2019
49
Reliability of two-point discrimination test in carpal tunnel syndrome patients. ( 29482409 )
2019
50
Hand anthropometry in patients with carpal tunnel syndrome: a case-control study with a matched control group of healthy volunteers. ( 29802717 )
2019

Variations for Carpal Tunnel Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Carpal Tunnel Syndrome:

76
# Symbol AA change Variation ID SNP ID
1 TTR p.Tyr134His VAR_007598 rs121918088

ClinVar genetic disease variations for Carpal Tunnel Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh37 Chromosome 18, 29178618: 29178618
2 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh38 Chromosome 18, 31598655: 31598655
3 TTR NM_000371.3(TTR): c.400T> C (p.Tyr134His) single nucleotide variant Pathogenic rs121918088 GRCh37 Chromosome 18, 29178594: 29178594
4 TTR NM_000371.3(TTR): c.400T> C (p.Tyr134His) single nucleotide variant Pathogenic rs121918088 GRCh38 Chromosome 18, 31598631: 31598631
5 TTR NM_000371.3(TTR): c.122G> A (p.Arg41Gln) single nucleotide variant Uncertain significance rs879254269 GRCh38 Chromosome 18, 31592948: 31592948
6 TTR NM_000371.3(TTR): c.122G> A (p.Arg41Gln) single nucleotide variant Uncertain significance rs879254269 GRCh37 Chromosome 18, 29172911: 29172911

Expression for Carpal Tunnel Syndrome

Search GEO for disease gene expression data for Carpal Tunnel Syndrome.

Pathways for Carpal Tunnel Syndrome

Pathways related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 B2M IL1B IL6 PSMD9 TGFB1 VEGFA
2
Show member pathways
12.78 B2M IL1B IL6 TGFB1 VEGFA
3 12.59 IL1B INS TGFB1 VEGFA
4
Show member pathways
12.57 BGN COL5A1 TGFB1 TTR
5 12.02 IL6 TGFB1 VEGFA
6 11.97 IL1B IL6 TAC1 VEGFA
7
Show member pathways
11.93 IL6 INS TGFB1
8
Show member pathways
11.91 B2M COL5A1 IL1B IL6 INS TGFB1
9 11.9 IL6 INS TGFB1
10
Show member pathways
11.89 IL1B IL6 TGFB1
11 11.86 IL6 INS TGFB1 VEGFA
12 11.85 IL1B IL6 TGFB1
13 11.74 IL6 INS VEGFA
14 11.73 IL1B IL6 TGFB1 VEGFA
15 11.72 IL1B IL6 TGFB1
16 11.65 IL1B IL6 INS TGFB1
17 11.59 IL1B IL6 TGFB1
18 11.56 IL1B IL6 TGFB1
19 11.56 IL1B IL6 TGFB1 VEGFA
20 11.5 IL1B IL6 TGFB1
21
Show member pathways
11.49 IL1B IL6 VEGFA
22 11.42 IL1B IL6 TGFB1 VEGFA
23 11.38 IL6 TGFB1 VEGFA
24 11.34 IL1B IL6 TGFB1
25 11.05 TGFB1 VEGFA
26 11.04 IL1B IL6 TGFB1
27 10.94 IL6 INS TGFB1 VEGFA

GO Terms for Carpal Tunnel Syndrome

Cellular components related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 B2M COL5A1 IL1B IL6 INS TAC1
2 extracellular matrix GO:0031012 9.56 BGN COL5A1 TGFB1 VEGFA
3 Golgi lumen GO:0005796 9.54 BGN INS TGFB1
4 secretory granule GO:0030141 9.5 IL1B TGFB1 VEGFA
5 endoplasmic reticulum lumen GO:0005788 9.46 B2M COL5A1 IL6 INS
6 extracellular region GO:0005576 9.32 B2M BGN COL5A1 IL1B IL6 INS

Biological processes related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.91 IL1B IL6 PMP22 TGFB1
2 inflammatory response GO:0006954 9.84 IL1B IL6 TAC1 TGFB1
3 positive regulation of cell proliferation GO:0008284 9.83 IL1B IL6 INS TGFB1 VEGFA
4 cytokine-mediated signaling pathway GO:0019221 9.78 IL1B IL6 TGFB1 VEGFA
5 positive regulation of cell migration GO:0030335 9.71 IL1B INS TGFB1 VEGFA
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 IL6 TGFB1 VEGFA
7 negative regulation of neurogenesis GO:0050768 9.63 IL1B IL6
8 positive regulation of protein complex assembly GO:0031334 9.63 TGFB1 VEGFA
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.63 IL6 TGFB1 VEGFA
10 positive regulation of protein localization to nucleus GO:1900182 9.62 INS TGFB1
11 cellular protein metabolic process GO:0044267 9.62 B2M IL6 INS TTR
12 positive regulation of protein autophosphorylation GO:0031954 9.61 INS VEGFA
13 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.59 TGFB1 VEGFA
14 positive regulation of histone acetylation GO:0035066 9.58 IL1B TGFB1
15 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.58 IL1B VEGFA
16 negative regulation of lipid catabolic process GO:0050995 9.57 IL1B INS
17 positive regulation of cellular protein metabolic process GO:0032270 9.56 INS TGFB1
18 positive regulation of glial cell proliferation GO:0060252 9.55 IL1B IL6
19 positive regulation of gene expression GO:0010628 9.55 IL1B IL6 INS TGFB1 VEGFA
20 positive regulation of acute inflammatory response GO:0002675 9.52 IL6 TAC1
21 wound healing GO:0042060 9.51 INS TGFB1
22 positive regulation of cell division GO:0051781 9.43 IL1B TGFB1 VEGFA
23 positive regulation of neuroinflammatory response GO:0150078 9.37 IL1B IL6
24 response to immobilization stress GO:0035902 9.32 TGFB1
25 response to vitamin D GO:0033280 9.3 TGFB1
26 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.26 IL1B IL6 INS TGFB1
27 regulation of signaling receptor activity GO:0010469 9.1 IL1B IL6 INS TGFB1 TTR VEGFA

Molecular functions related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL6 TGFB1 VEGFA
2 cytokine activity GO:0005125 8.92 IL1B IL6 TGFB1 VEGFA

Sources for Carpal Tunnel Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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