CTS1
MCID: CRP001
MIFTS: 71

Carpal Tunnel Syndrome (CTS1)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Carpal Tunnel Syndrome

MalaCards integrated aliases for Carpal Tunnel Syndrome:

Name: Carpal Tunnel Syndrome 58 12 77 26 55 30 56 6 44 3 45 15 64 17 74
Carpal Tunnel Syndrome, Familial 58 13 6 41 74
Cts 58 26 76 3 17
Amyotrophy, Thenar, of Carpal Origin 58 26
Cts1 58 76
Compression Neuropathy, Carpal Tunnel 26
Entrapment Neuropathy, Carpal Tunnel 26
Thenar Amyotrophy of Crapal Origin 76
Median Neuropathy, Carpal Tunnel 26
Carpal Tunnel Median Neuropathy 12
Distal Median Nerve Compression 26
Median Neuropathy Carpal Tunnel 76
Familial Carpal Tunnel Syndrome 38
Distal Median Nerve Entrapment 26
Cts - Carpal Tunnel Syndrome 12
Carpal Tunnel Syndrome 1 76
Median Nerve Entrapment 12
Carpal Tunnel 26
Carpal Canal 26

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
carpal tunnel syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:12169
OMIM 58 115430
KEGG 38 H00798
ICD9CM 36 354.0
MeSH 45 D002349
NCIt 51 C34450
SNOMED-CT 69 57406009
ICD10 34 G56.0 G56.00
MedGen 43 C0007286

Summaries for Carpal Tunnel Syndrome

MedlinePlus : 44 You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. Suddenly, a sharp, piercing pain shoots through the wrist and up your arm. Just a passing cramp? It could be carpal tunnel syndrome. The carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. It contains nerve and tendons. Sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. Symptoms usually start gradually. As they worsen, grasping objects can become difficult. Often, the cause is having a smaller carpal tunnel than other people do. Other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. Women are three times more likely to have carpal tunnel syndrome than men. Early diagnosis and treatment are important to prevent permanent nerve damage. Your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. Treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Carpal Tunnel Syndrome, also known as carpal tunnel syndrome, familial, is related to peripheral nervous system disease and epicondylitis, and has symptoms including seizures, tremor and back pain. An important gene associated with Carpal Tunnel Syndrome is TTR (Transthyretin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Prednisolone phosphate and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and thyroid, and related phenotypes are peripheral neuropathy and constrictive median neuropathy

Genetics Home Reference : 26 Carpal tunnel syndrome is a disorder caused by disturbances in nerve function (neuropathy), leading to pain and numbness or tingling (paresthesia) primarily in the wrist and hand. While carpal tunnel syndrome can occur at any age, it most often affects people between the ages of 40 and 60. In more than half of cases, both hands are affected; however, the severity may vary between hands. When only one hand is affected, it is most often the hand used for writing (the dominant hand).

CDC : 3 The goal of ergonomics (i.e. the scientific study of people at work) is to prevent soft tissue injuries and musculoskeletal disorders (MSDs) caused by sudden or sustained exposure to force, vibration, repetitive motion, and awkward posture. To create an ergonomically sound work environment, NIOSH ergonomists and industrial hygienists recommend designing tasks, work spaces, controls, displays, tools, lighting, and equipment to fit employee’s physical capabilities and limitations. On this page you will find the Musculoskeletal Health Program’s ergonomic recommendations and musculoskeletal health-related research.

NINDS : 55 Carpal tunnel syndrome (CTS) occurs when  the median nerve, which runs from the forearm into the palm of the hand,  becomes pressed or squeezed at the wrist. The carpal tunnel is a narrow, rigid passageway of ligament and bones at the base of the hand that houses the median nerve and the tendons that bend the fingers. The median nerve provides feeling to the palm side of the thumb and to most of the fingers. Symptoms usually start gradually, with numbness, tingling, weakness, and sometimes pain in the hand and wrist.  CTS makes it difficult for some people to drive, read a book, grasp small objects, or do other tasks. Sometimes no direct cause of CTS can be found; contributing factors include trauma or injury to the wrist that causes swelling, as well as thyroid disease, rheumatoid arthritis, and fluid retention during pregnancy. Women are three times more likely than men to develop carpal tunnel syndrome. The disorder usually occurs only in adults.

UniProtKB/Swiss-Prot : 76 Carpal tunnel syndrome 1: A condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.

PubMed Health : 64 About carpal tunnel syndrome: Most people's hands briefly "fall asleep" every now and then. They then feel numb or tingly. Although this is a little unpleasant, it's usually over very quickly. Carpal tunnel syndrome has similar symptoms – but they keep coming back again and are often painful.The carpal tunnel is a passageway inside of the wrist that is surrounded by bones and connective tissue. It runs along the inner side of the wrist to the base of the hand and is covered by a strong, fibrous band made up of connective tissue, called the flexor retinaculum. The carpal tunnel contains tendons and the median nerve. This nerve is responsible for sensation and movement in the ball of the thumb and some parts of the hand. If the tissue inside the carpal tunnel swells up, it can put pressure on the median nerve, which is what causes carpal tunnel syndrome. The symptoms often go away on their own, but they can sometimes last for quite a long time. There are a number of different treatments that can provide relief.

Wikipedia : 77 Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels... more...

Description from OMIM: 115430

Related Diseases for Carpal Tunnel Syndrome

Diseases related to Carpal Tunnel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2529)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 30.7 IL6 INS PMP22 PSMD9 SH3TC2 TAC1
2 epicondylitis 30.6 COL5A1 TAC1
3 mononeuropathy 30.5 PMP22 SH3TC2 TAC1
4 hereditary amyloidosis 30.4 B2M TTR
5 nerve compression syndrome 30.3 B2M COL5A1 PSMD9 TTR
6 osteoarthritis 30.2 IL1B IL6 TGFB1
7 diabetic neuropathy 30.0 INS PMP22 VEGFA
8 dupuytren contracture 30.0 IL1B TGFB1 VEGFA
9 rheumatoid arthritis 30.0 IL1B IL6 TGFB1 TTR VEGFA
10 interstitial lung disease 30.0 IL1B IL6 TGFB1
11 complex regional pain syndrome 29.9 IL1B IL6 TAC1
12 burns 29.8 IL1B INS TTR
13 al amyloidosis 29.8 B2M TTR
14 extramedullary plasmacytoma 29.8 B2M IL6
15 osteonecrosis of the jaw 29.8 TGFB1 VEGFA
16 peritonitis 29.7 B2M IL1B IL6
17 brain edema 29.5 IL1B IL6 VEGFA
18 prostatitis 29.5 IL1B IL6 TGFB1
19 pneumoconiosis 29.5 IL1B IL6 TGFB1
20 spinal disease 29.4 IL6 VEGFA
21 ascaris lumbricoides infection 29.4 IL1B IL6
22 acquired immunodeficiency syndrome 29.4 B2M IL1B IL6
23 esophagitis 29.4 IL1B IL6 TGFB1
24 sleep apnea 29.3 IL1B IL6 INS
25 poems syndrome 29.3 IL1B IL6 VEGFA
26 endometriosis 29.3 IL1B IL6 VEGFA
27 bone disease 29.3 B2M IL1B IL6
28 amyloid tumor 29.2 B2M TTR
29 periapical periodontitis 29.2 IL1B IL6
30 meningoencephalitis 29.2 B2M IL6 TAC1
31 tendinopathy 29.1 COL5A1 VEGFA
32 kidney disease 29.1 B2M IL6 INS TGFB1 TTR
33 arteries, anomalies of 29.1 IL1B IL6 INS VEGFA
34 fatty liver disease 29.0 IL1B IL6 INS
35 critical limb ischemia 29.0 IL6 VEGFA
36 primary effusion lymphoma 29.0 IL6 VEGFA
37 intestinal disease 28.8 IL1B IL6 VEGFA
38 chagas disease 28.7 IL1B IL6 TGFB1
39 cytomegalovirus infection 28.7 B2M IL1B IL6
40 large intestine cancer 28.6 IL1B IL6 INS VEGFA
41 viral encephalitis 28.6 IL1B IL6 VEGFA
42 ewing sarcoma 28.6 IL1B IL6 INS TGFB1 VEGFA
43 central nervous system disease 28.6 IL1B IL6 TTR
44 chronic kidney failure 28.4 B2M IL6 INS TGFB1 TTR
45 bronchial disease 28.4 IL1B IL6 TAC1
46 autoimmune disease 28.1 IL1B IL6 INS
47 nervous system disease 27.7 IL1B IL6 INS TTR VEGFA
48 mononeuropathy of the median nerve, mild 12.5
49 amyloidosis, hereditary, transthyretin-related 11.7
50 acromegaly 11.6

Graphical network of the top 20 diseases related to Carpal Tunnel Syndrome:



Diseases related to Carpal Tunnel Syndrome

Symptoms & Phenotypes for Carpal Tunnel Syndrome

Human phenotypes related to Carpal Tunnel Syndrome:

33
# Description HPO Frequency HPO Source Accession
1 peripheral neuropathy 33 HP:0009830
2 constrictive median neuropathy 33 HP:0012185
3 digital flexor tenosynovitis 33 HP:0012276
4 reduced circulating vitamin b6 level 33 HP:0008326

Symptoms via clinical synopsis from OMIM:

58
Neuro:
constrictive median neuropathy
tunnel sign

Misc:
responsive to pyridoxine administration
early onset age

Limbs:
thickened transverse carpal ligament
digital flexor tenosynovitis

Lab:
vitamin b6 deficiency

Clinical features from OMIM:

115430

UMLS symptoms related to Carpal Tunnel Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, muscle cramp

MGI Mouse Phenotypes related to Carpal Tunnel Syndrome:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 B2M COL5A1 IL1B IL6 INS SH3TC2
2 homeostasis/metabolism MP:0005376 10.13 B2M BGN IL1B IL6 INS PMP22
3 behavior/neurological MP:0005386 10.11 BGN IL6 INS PMP22 SH3TC2 TAC1
4 growth/size/body region MP:0005378 10.11 B2M BGN COL5A1 IL1B IL6 INS
5 mortality/aging MP:0010768 10.07 B2M BGN COL5A1 IL1B IL6 INS
6 integument MP:0010771 10.06 B2M BGN COL5A1 IL1B IL6 INS
7 digestive/alimentary MP:0005381 9.95 B2M IL6 INS TGFB1 TTR VEGFA
8 muscle MP:0005369 9.87 BGN IL6 INS PMP22 SH3TC2 TGFB1
9 renal/urinary system MP:0005367 9.73 IL6 INS TAC1 TGFB1 TTR VEGFA
10 reproductive system MP:0005389 9.7 B2M BGN IL6 INS PMP22 TGFB1
11 skeleton MP:0005390 9.5 BGN IL1B IL6 INS SH3TC2 TGFB1
12 vision/eye MP:0005391 9.17 COL5A1 IL6 INS PMP22 TGFB1 TTR

Drugs & Therapeutics for Carpal Tunnel Syndrome

PubMedHealth treatment related to Carpal Tunnel Syndrome: 64

Mild to moderate carpal tunnel syndrome can usually be treated with a splint at first. The splint is worn at night to prevent the wrist from bending too far. Doctors may also advise you to avoid activities thought to be related to this condition.Injecting corticosteroids into the carpal tunnel can provide temporary relief, but corticosteroid injections aren't an effective long-term solution.Surgery may also be considered as a treatment. During the operation, the flexor retinaculum that arches across the base of the hand is cut: to reduce pressure on the median nerve. This procedure can make the symptoms go away for good, but it's not always necessary. Other treatments are usually preferred, especially in early stages of the condition. Immediate surgery is only needed in very rare cases of acute carpal tunnel syndrome.Other treatments such as acupuncture, ultrasound therapy, laser therapy or magnetic field therapy may also be recommended. But there is no evidence that they are effective in the treatment of carpal tunnel syndrome.Many people take painkillers to relieve their symptoms – particularly non-steroidal anti-inflammatory drugs (NSAIDs), which are available over-the-counter at pharmacies and drugstores. Taking vitamin B6 products is sometimes also recommended to strengthen the nerves. So far, though, research suggests that neither NSAIDs nor vitamin B6 can provide enough pain relief.

Drugs for Carpal Tunnel Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 184)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 302-25-0
2
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 50-24-8 5755
4
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 2921-57-5
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 83-43-2 6741
6
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
7
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
8
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
9
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
10
tannic acid Approved Phase 4 1401-55-4
11
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
12
Bupivacaine Approved, Investigational Phase 4,Phase 1,Early Phase 1,Not Applicable 38396-39-3, 2180-92-9 2474
13
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
14
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
15
Cefazolin Approved Phase 4 25953-19-9 33255 656510
16
Vancomycin Approved Phase 4 1404-90-6 14969 441141
17
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
18
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
19
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
20
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
21
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
22
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
23
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
24
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
25
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-30-3 6037
27
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 2920-86-7
28 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
29 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
32 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
33 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
35 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
36 Antiemetics Phase 4,Phase 2,Phase 3,Not Applicable
37 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable
38 Autonomic Agents Phase 4,Phase 2,Phase 3,Not Applicable
39 Methylprednisolone Acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
40 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
43 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
46 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Narcotics Phase 4,Phase 2
49 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Analgesics, Opioid Phase 4,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 230)
# Name Status NCT ID Phase Drugs
1 Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
2 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration Active, not recruiting NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
3 Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome Completed NCT02140632 Phase 4
4 Length of Post Operative Dressing After Carpal Tunnel Release Completed NCT01310218 Phase 4
5 Injection Versus Splinting in Carpal Tunnel Syndrome Active, not recruiting NCT02038452 Phase 4 Depo-Medrone
6 Exparel and Education to Avoid Opioids After Carpal Tunnel Release Recruiting NCT03867539 Phase 4
7 Preoperative Antibiotics for Carpal Tunnel Release Surgery Recruiting NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
8 Comparison of the Efficacy of Corticosteroid Injection and ESWT in Patients With CTS Not yet recruiting NCT03792945 Phase 4 local injection
9 Postoperative Alpha Lipoic Acid in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
10 Myofascial Release on Electrophysiological Measures of Pregnant Women With CTS Completed NCT03802448 Phase 4
11 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome Completed NCT00277563 Phase 4
12 Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
13 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
14 Narcotic vs. Non-narcotic Pain Study Protocol Recruiting NCT01974609 Phase 4 Narcotic;non-narcotic
15 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
16 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
17 Onset and Duration of Forearm Nerve Blockade Completed NCT03649763 Phase 4 Lidocaine;Bupivacaine;Lidocaine
18 Distribution Circumferential Versus Non Circumferential of Mepivacaine in the Median and Ulnar Nerves Completed NCT01603680 Phase 4
19 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
20 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery Terminated NCT02029235 Phase 4 Acetaminophen/Ibuprofen;Acetaminophen/Hydrocodone
21 Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture Recruiting NCT03749616 Phase 4 Ibuprofen;Acetaminophen
22 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
23 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Unknown status NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
24 Carpal Tunnel Syndrome Release Using PSU Retractor Unknown status NCT01017471 Phase 3
25 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
26 Gabapentin for Carpal Tunnel Syndrome Completed NCT00137735 Phase 3 Gabapentin
27 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
28 Steroid Injection Treatment of Carpal Tunnel Syndrome Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
29 Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
30 Preoperative Gabapentine for Carpal Tunnel Completed NCT01632215 Phase 3 Gabapentine
31 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
32 A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
33 Efficacy/Safety of Octreotide Acetate in Patients With Uncontrolled Acromegaly Completed NCT00372697 Phase 3 Octreotide acetate 30 mg suspension
34 Assessment of 18F-Florbetaben Whole-body PET for the Detection of Cardiac and Extracardiac Sites of Amyloid Deposits Not yet recruiting NCT03616496 Phase 2, Phase 3 Neuraceq 300MBq/mL Solution for Injection for PET imaging
35 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
36 Carpal Tunnel Syndrome Treated With 830nm Diode Laser Unknown status NCT00514462 Phase 1, Phase 2
37 Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Unknown status NCT03111186 Phase 2 Oxycodone Hcl 5Mg;Ibuprofen 400 mg;Acetaminophen 650 mg
38 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
39 A Pilot Study to Evaluate the Effectiveness of Ultrasound Guided Looped Thread Carpal Tunnel Release Completed NCT03476486 Phase 2
40 Fascial Manipulation on the Treatment of Carpal Tunnel Syndrome Completed NCT02495298 Phase 2
41 Botulinum Toxin for Carpal Tunnel Syndrome Withdrawn NCT00701233 Phase 2 Botulinum toxin;Corticosteroid injection into Carpal Tunnel
42 Alpha Lipoic Acid on Clinical and Electrophysiological Recovery in Carpal Tunnel Syndrome Undergoing Surgical Release Completed NCT02382328 Phase 2 alpha lipoic acid;Placebo
43 Percutaneous Treatment of Carpal Tunnel Syndrome With Scan Completed NCT02514317 Phase 2
44 The Treatment of the Median Nerve for the Elimination of the Symptoms Associated With the Carpal Tunnel Syndrome Completed NCT00634738 Phase 1, Phase 2
45 Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome Completed NCT00991068 Phase 2 Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch
46 Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome Completed NCT01093209 Phase 2
47 Treatment Efficacy of OMT for Carpal Tunnel Syndrome Completed NCT00394043 Phase 2
48 BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome Completed NCT02070302 Phase 2 Botulinum Toxin Type A;Placebo
49 Acupuncture for Carpal Tunnel Syndrome Completed NCT00000394 Phase 2
50 The Treatment of Carpal Tunnel Syndrome Using Thumb Pressure Along the Median Nerve Completed NCT00634699 Phase 1, Phase 2

Search NIH Clinical Center for Carpal Tunnel Syndrome

Cochrane evidence based reviews: carpal tunnel syndrome

Genetic Tests for Carpal Tunnel Syndrome

Genetic tests related to Carpal Tunnel Syndrome:

# Genetic test Affiliating Genes
1 Carpal Tunnel Syndrome 30 TTR

Anatomical Context for Carpal Tunnel Syndrome

MalaCards organs/tissues related to Carpal Tunnel Syndrome:

42
Testes, Bone, Thyroid, Heart, Breast, Brain, Liver

Publications for Carpal Tunnel Syndrome

Articles related to Carpal Tunnel Syndrome:

(show top 50) (show all 3278)
# Title Authors Year
1
Prospective evaluation of finger two-point discrimination and carpal tunnel syndrome among women with breast cancer receiving adjuvant aromatase inhibitor therapy. ( 31079282 )
2019
2
Solitary Calcified Nodules as the Cause of Carpal Tunnel Syndrome: Two Case Reports and Literature Reviews. ( 30930838 )
2019
3
Can we accurately predict nerve conduction study outcome using a carpal tunnel syndrome questionnaire? ( 30935878 )
2019
4
Flexor Tenosynovectomy for Recurrent Carpal Tunnel Syndrome: A Retrospective Case Series of 108 Hands. ( 30939941 )
2019
5
Increased Risk of Coronary Artery Disease in People with a Previous Diagnosis of Carpal Tunnel Syndrome: A Nationwide Retrospective Population-Based Case-Control Study. ( 30941360 )
2019
6
Comparison of Ultrasound-Guided Versus Landmark-Based Corticosteroid Injection for Carpal Tunnel Syndrome: A Prospective Randomized Trial. ( 30947825 )
2019
7
Carpal tunnel syndrome and spinal canal stenosis: harbingers of transthyretin amyloid cardiomyopathy? ( 30953182 )
2019
8
Practice patterns in the conservative treatment of carpal tunnel syndrome: Survey results from members of the American Society of Hand Therapy. ( 30956070 )
2019
9
Timing of extracorporeal shock wave therapy in rabbits with carpal tunnel syndrome. ( 30964964 )
2019
10
Sonographic follow-up after endoscopic carpal tunnel release for severe carpal tunnel syndrome: a one-year neuroanatomical prospective observational study. ( 30967143 )
2019
11
The Effects of Nerve and Tendon Gliding Exercises Combined with Low-level Laser or Ultrasound Therapy in Carpal Tunnel Syndrome. ( 30967707 )
2019
12
Management of Recalcitrant Carpal Tunnel Syndrome. ( 30973521 )
2019
13
Acupuncture and Related Interventions for the Treatment of Symptoms Associated with Carpal Tunnel Syndrome: Summary of a Cochrane Review. ( 30975514 )
2019
14
Diagnostic Accuracy of Ultrasound Parameters in Carpal Tunnel Syndrome: Additional Criteria for Diagnosis. ( 30993769 )
2019
15
Does insurance coverage affect use of tests and treatments for working age individuals with carpal tunnel syndrome in the United States? Analysis of the National Ambulatory Medical Care Survey (2005-2014). ( 31002811 )
2019
16
The diagnostic value of clinical examinations when diagnosing carpal tunnel syndrome assisted by nerve conduction studies. ( 30396816 )
2019
17
Hand anthropometry in patients with carpal tunnel syndrome: a case-control study with a matched control group of healthy volunteers. ( 29802717 )
2019
18
Carpal Tunnel Syndrome: Evaluation of the Effects of Low-Level Laser Therapy With Ultrasound Strain Imaging. ( 29892976 )
2019
19
Variation in Nonsurgical Services for Carpal Tunnel Syndrome Across a Large Integrated Health Care System. ( 30579690 )
2019
20
Cold effect in median nerve conductions in clinical carpal tunnel syndrome with normal nerve conduction studies. ( 30538080 )
2019
21
Clinical Care Redesign to Improve Value in Carpal Tunnel Syndrome: A Before-and-After Implementation Study. ( 30502930 )
2019
22
Cost-Effectiveness Evaluation of Manual Physical Therapy Versus Surgery for Carpal Tunnel Syndrome: Evidence From a Randomized Clinical Trial. ( 30501389 )
2019
23
Revision surgery in carpal tunnel syndrome: a retrospective study comparing the Canaletto® device alone versus a combination of Canaletto® and Dynavisc® gel. ( 30472072 )
2019
24
Ultrasound, Clinical, and Electrophysiological Findings in Persistent Carpal Tunnel Syndrome. ( 30468290 )
2019
25
Observational pilot study of patients with carpal tunnel syndrome treated with Nucleo CMP Forte™. ( 30451573 )
2019
26
Recurrence of carpal tunnel syndrome in isolated non-syndromic macrodactyly: DTI examination of a giant median nerve. ( 30343441 )
2019
27
Nerve hydrodissection for carpal tunnel syndrome: A prospective, randomized, double-blind, controlled trial. ( 30339737 )
2019
28
Is manual therapy based on neurodynamic techniques effective in the treatment of carpal tunnel syndrome? A randomized controlled trial. ( 30306805 )
2019
29
Trifid Median Nerve: A Rare Variant in a Patient With Carpal Tunnel Syndrome. ( 30277913 )
2019
30
Sonographic Findings Associated With Carpal Tunnel Syndrome. ( 30241975 )
2019
31
Median Nerve Ultrasonography Measurements Correlate With Electrodiagnostic Carpal Tunnel Syndrome Severity. ( 30216244 )
2019
32
Utilization of Electrodiagnostic Testing for Carpal Tunnel Syndrome by General Practitioners Prior to Hand Surgery Consultation. ( 30188191 )
2019
33
Acute exacerbation of carpal tunnel syndrome after Radiesse® injection for hand rejuvenation. ( 30183067 )
2019
34
The relationship of pain on the upper extremity functions and quality of life in patients with carpal tunnel syndrome. ( 30149437 )
2019
35
Prevalence of carpal tunnel syndrome presenting with symptoms in an ulnar nerve distribution: A prospective study. ( 30051917 )
2019
36
Platelet-rich plasma injections for carpal tunnel syndrome: a systematic and comprehensive review. ( 30022241 )
2019
37
Diffusion tensor imaging findings of the median nerve before and after carpal tunnel corticosteroid injection in patients with carpal tunnel syndrome: a preliminary study. ( 29979105 )
2019
38
Ultrasonography for the Diagnosis of Carpal Tunnel Syndrome in Diabetic Patients: Missing the Mark? ( 29966141 )
2019
39
Mental and Physical Health Disparities in Patients With Carpal Tunnel Syndrome Living With High Levels of Social Deprivation. ( 29945843 )
2019
40
Thumb Opposition Recovery Following Surgery for Severe Carpal Tunnel Syndrome: A Clinical, Radiological, and Electrophysiological Pilot Study. ( 29934085 )
2019
41
Outcomes of Endoscopic Carpal Tunnel Release With Ring Finger Flexor Digitorum Superficialis Opponensplasty in Severe Carpal Tunnel Syndrome. ( 31072662 )
2019
42
Al-hijamah (wet cupping therapy of prophetic medicine) as a novel alternative to surgery for carpal tunnel syndrome. ( 31056546 )
2019
43
Treatment of carpal tunnel syndrome: Surgery or more conservative management? ( 31049992 )
2019
44
Influence of Clinical, Psychological and Psychophysical Variables on Long-term Treatment Outcomes in Carpal Tunnel Syndrome: Evidence from a Randomized Clinical Trial. ( 31046185 )
2019
45
The comparison of limited-incision versus standard-incision in treatment of carpal tunnel syndrome: A meta-analysis of randomized controlled trials. ( 31045782 )
2019
46
Carpal Malalignment as a Predictor of Delayed Carpal Tunnel Syndrome after Colles' Fracture. ( 31044126 )
2019
47
Pseudo carpal tunnel syndrome due to incomplete pure sensory stroke. ( 31041613 )
2019
48
Focal myokymia in carpal tunnel syndrome. ( 31041139 )
2019
49
Hand Pain and Sensory Deficits: Carpal Tunnel Syndrome. ( 31039690 )
2019
50
Carpal Tunnel Syndrome: Treating Hand Pain and Numbness. ( 31039689 )
2019

Variations for Carpal Tunnel Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Carpal Tunnel Syndrome:

76
# Symbol AA change Variation ID SNP ID
1 TTR p.Tyr134His VAR_007598 rs121918088

ClinVar genetic disease variations for Carpal Tunnel Syndrome:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 TTR NM_000371.3(TTR): c.148G> A (p.Val50Met) single nucleotide variant Pathogenic rs28933979 GRCh37 Chromosome 18, 29172937: 29172937
2 TTR NM_000371.3(TTR): c.148G> A (p.Val50Met) single nucleotide variant Pathogenic rs28933979 GRCh38 Chromosome 18, 31592974: 31592974
3 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh37 Chromosome 18, 29178618: 29178618
4 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh38 Chromosome 18, 31598655: 31598655
5 TTR NM_000371.3(TTR): c.400T> C (p.Tyr134His) single nucleotide variant Pathogenic rs121918088 GRCh37 Chromosome 18, 29178594: 29178594
6 TTR NM_000371.3(TTR): c.400T> C (p.Tyr134His) single nucleotide variant Pathogenic rs121918088 GRCh38 Chromosome 18, 31598631: 31598631
7 TTR NM_000371.3(TTR): c.250T> C (p.Phe84Leu) single nucleotide variant Pathogenic/Likely pathogenic rs121918091 GRCh37 Chromosome 18, 29175132: 29175132
8 TTR NM_000371.3(TTR): c.250T> C (p.Phe84Leu) single nucleotide variant Pathogenic/Likely pathogenic rs121918091 GRCh38 Chromosome 18, 31595169: 31595169
9 TTR NM_000371.3(TTR): c.280G> C (p.Asp94His) single nucleotide variant Uncertain significance rs730881164 GRCh38 Chromosome 18, 31595199: 31595199
10 TTR NM_000371.3(TTR): c.280G> C (p.Asp94His) single nucleotide variant Uncertain significance rs730881164 GRCh37 Chromosome 18, 29175162: 29175162
11 TTR NM_000371.3(TTR): c.122G> A (p.Arg41Gln) single nucleotide variant Uncertain significance rs879254269 GRCh38 Chromosome 18, 31592948: 31592948
12 TTR NM_000371.3(TTR): c.122G> A (p.Arg41Gln) single nucleotide variant Uncertain significance rs879254269 GRCh37 Chromosome 18, 29172911: 29172911

Expression for Carpal Tunnel Syndrome

Search GEO for disease gene expression data for Carpal Tunnel Syndrome.

Pathways for Carpal Tunnel Syndrome

Pathways related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 B2M IL1B IL6 PSMD9 TGFB1 VEGFA
2
Show member pathways
12.78 B2M IL1B IL6 TGFB1 VEGFA
3 12.59 IL1B INS TGFB1 VEGFA
4
Show member pathways
12.57 BGN COL5A1 TGFB1 TTR
5 12.02 IL6 TGFB1 VEGFA
6 11.97 IL1B IL6 TAC1 VEGFA
7
Show member pathways
11.93 IL6 INS TGFB1
8
Show member pathways
11.91 B2M COL5A1 IL1B IL6 INS TGFB1
9 11.9 IL6 INS TGFB1
10
Show member pathways
11.89 IL1B IL6 TGFB1
11 11.86 IL6 INS TGFB1 VEGFA
12 11.85 IL1B IL6 TGFB1
13 11.74 IL6 INS VEGFA
14 11.73 IL1B IL6 TGFB1 VEGFA
15 11.72 IL1B IL6 TGFB1
16 11.65 IL1B IL6 INS TGFB1
17 11.59 IL1B IL6 TGFB1
18 11.56 IL1B IL6 TGFB1
19 11.56 IL1B IL6 TGFB1 VEGFA
20 11.5 IL1B IL6 TGFB1
21
Show member pathways
11.49 IL1B IL6 VEGFA
22 11.42 IL1B IL6 TGFB1 VEGFA
23 11.38 IL6 TGFB1 VEGFA
24 11.34 IL1B IL6 TGFB1
25 11.05 TGFB1 VEGFA
26 11.04 IL1B IL6 TGFB1
27 10.94 IL6 INS TGFB1 VEGFA

GO Terms for Carpal Tunnel Syndrome

Cellular components related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 B2M COL5A1 IL1B IL6 INS TAC1
2 extracellular matrix GO:0031012 9.56 BGN COL5A1 TGFB1 VEGFA
3 Golgi lumen GO:0005796 9.54 BGN INS TGFB1
4 secretory granule GO:0030141 9.5 IL1B TGFB1 VEGFA
5 endoplasmic reticulum lumen GO:0005788 9.46 B2M COL5A1 IL6 INS
6 extracellular region GO:0005576 9.32 B2M BGN COL5A1 IL1B IL6 INS

Biological processes related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.91 IL1B IL6 PMP22 TGFB1
2 inflammatory response GO:0006954 9.84 IL1B IL6 TAC1 TGFB1
3 positive regulation of cell proliferation GO:0008284 9.83 IL1B IL6 INS TGFB1 VEGFA
4 cytokine-mediated signaling pathway GO:0019221 9.78 IL1B IL6 TGFB1 VEGFA
5 positive regulation of cell migration GO:0030335 9.71 IL1B INS TGFB1 VEGFA
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 IL6 TGFB1 VEGFA
7 negative regulation of neurogenesis GO:0050768 9.63 IL1B IL6
8 positive regulation of protein complex assembly GO:0031334 9.63 TGFB1 VEGFA
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.63 IL6 TGFB1 VEGFA
10 positive regulation of protein localization to nucleus GO:1900182 9.62 INS TGFB1
11 cellular protein metabolic process GO:0044267 9.62 B2M IL6 INS TTR
12 positive regulation of protein autophosphorylation GO:0031954 9.61 INS VEGFA
13 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.59 TGFB1 VEGFA
14 positive regulation of histone acetylation GO:0035066 9.58 IL1B TGFB1
15 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.58 IL1B VEGFA
16 negative regulation of lipid catabolic process GO:0050995 9.57 IL1B INS
17 positive regulation of cellular protein metabolic process GO:0032270 9.56 INS TGFB1
18 positive regulation of glial cell proliferation GO:0060252 9.55 IL1B IL6
19 positive regulation of gene expression GO:0010628 9.55 IL1B IL6 INS TGFB1 VEGFA
20 positive regulation of acute inflammatory response GO:0002675 9.52 IL6 TAC1
21 wound healing GO:0042060 9.51 INS TGFB1
22 positive regulation of cell division GO:0051781 9.43 IL1B TGFB1 VEGFA
23 positive regulation of neuroinflammatory response GO:0150078 9.37 IL1B IL6
24 response to immobilization stress GO:0035902 9.32 TGFB1
25 response to vitamin D GO:0033280 9.3 TGFB1
26 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.26 IL1B IL6 INS TGFB1
27 regulation of signaling receptor activity GO:0010469 9.1 IL1B IL6 INS TGFB1 TTR VEGFA

Molecular functions related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL6 TGFB1 VEGFA
2 cytokine activity GO:0005125 8.92 IL1B IL6 TGFB1 VEGFA

Sources for Carpal Tunnel Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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