Carpal Tunnel Syndrome (CTS1)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Carpal Tunnel Syndrome

MalaCards integrated aliases for Carpal Tunnel Syndrome:

Name: Carpal Tunnel Syndrome 57 12 76 54 29 55 6 43 3 44 15 63 73
Carpal Tunnel Syndrome, Familial 57 13 6 40 73
Cts 57 75 3
Cts1 57 75
Amyotrophy, Thenar, of Carpal Origin 57
Thenar Amyotrophy of Crapal Origin 75
Carpal Tunnel Median Neuropathy 12
Median Neuropathy Carpal Tunnel 75
Familial Carpal Tunnel Syndrome 37
Cts - Carpal Tunnel Syndrome 12
Carpal Tunnel Syndrome 1 75
Median Nerve Entrapment 12



autosomal dominant


carpal tunnel syndrome:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 57 115430
Disease Ontology 12 DOID:12169
ICD10 33 G56.0 G56.00
ICD9CM 35 354.0
MeSH 44 D002349
NCIt 50 C34450
SNOMED-CT 68 57406009
MedGen 42 C0007286
KEGG 37 H00798

Summaries for Carpal Tunnel Syndrome

MedlinePlus : 43 You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. Suddenly, a sharp, piercing pain shoots through the wrist and up your arm. Just a passing cramp? It could be carpal tunnel syndrome. The carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. It contains nerve and tendons. Sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. Symptoms usually start gradually. As they worsen, grasping objects can become difficult. Often, the cause is having a smaller carpal tunnel than other people do. Other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. Women are three times more likely to have carpal tunnel syndrome than men. Early diagnosis and treatment are important to prevent permanent nerve damage. Your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. Treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Carpal Tunnel Syndrome, also known as carpal tunnel syndrome, familial, is related to peripheral nervous system disease and epicondylitis, and has symptoms including seizures, tremor and back pain. An important gene associated with Carpal Tunnel Syndrome is TTR (Transthyretin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Prednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and thyroid, and related phenotypes are peripheral neuropathy and constrictive median neuropathy

Genetics Home Reference : 25 Carpal tunnel syndrome is a disorder caused by disturbances in nerve function (neuropathy), leading to pain and numbness or tingling (paresthesia) primarily in the wrist and hand. While carpal tunnel syndrome can occur at any age, it most often affects people between the ages of 40 and 60. In more than half of cases, both hands are affected; however, the severity may vary between hands. When only one hand is affected, it is most often the hand used for writing (the dominant hand).

CDC : 3 The goal of ergonomics (i.e. the scientific study of people at work) is to prevent soft tissue injuries and musculoskeletal disorders (MSDs) caused by sudden or sustained exposure to force, vibration, repetitive motion, and awkward posture. To create an ergonomically sound work environment, NIOSH ergonomists and industrial hygienists recommend designing tasks, work spaces, controls, displays, tools, lighting, and equipment to fit employee’s physical capabilities and limitations. On this page you will find the Musculoskeletal Health Program’s ergonomic recommendations and musculoskeletal health-related research.

NINDS : 54 Carpal tunnel syndrome (CTS) occurs when  the median nerve, which runs from the forearm into the palm of the hand,  becomes pressed or squeezed at the wrist. The carpal tunnel is a narrow, rigid passageway of ligament and bones at the base of the hand that houses the median nerve and the tendons that bend the fingers. The median nerve provides feeling to the palm side of the thumb and to most of the fingers. Symptoms usually start gradually, with numbness, tingling, weakness, and sometimes pain in the hand and wrist.  CTS makes it difficult for some people to drive, read a book, grasp small objects, or do other tasks. Sometimes no direct cause of CTS can be found; contributing factors include trauma or injury to the wrist that causes swelling, as well as thyroid disease, rheumatoid arthritis, and fluid retention during pregnancy. Women are three times more likely than men to develop carpal tunnel syndrome. The disorder usually occurs only in adults.

UniProtKB/Swiss-Prot : 75 Carpal tunnel syndrome 1: A condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.

PubMed Health : 63 About carpal tunnel syndrome: Most people's hands briefly "fall asleep" every now and then. They then feel numb or tingly. Although this is a little unpleasant, it's usually over very quickly. Carpal tunnel syndrome has similar symptoms – but they keep coming back again and are often painful.The carpal tunnel is a passageway inside of the wrist that is surrounded by bones and connective tissue. It runs along the inner side of the wrist to the base of the hand and is covered by a strong, fibrous band made up of connective tissue, called the flexor retinaculum. The carpal tunnel contains tendons and the median nerve. This nerve is responsible for sensation and movement in the ball of the thumb and some parts of the hand. If the tissue inside the carpal tunnel swells up, it can put pressure on the median nerve, which is what causes carpal tunnel syndrome. The symptoms often go away on their own, but they can sometimes last for quite a long time. There are a number of different treatments that can provide relief.

Wikipedia : 76 Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels... more...

Description from OMIM: 115430

Related Diseases for Carpal Tunnel Syndrome

Diseases related to Carpal Tunnel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2347)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 31.4 TTR TAC1 SH3TC2 PSMD9 PMP22 INS
2 epicondylitis 30.6 COL5A1 TAC1
3 mononeuropathy 30.5 TAC1 SH3TC2 PMP22
4 arthritis 30.3 ACAN IL1B IL6 TGFB1
5 nerve compression syndrome 30.3 TTR PSMD9 COL5A1 B2M
6 hereditary amyloidosis 30.2 B2M TTR
7 complex regional pain syndrome 30.1 TAC1 IL6 IL1B
8 rheumatoid arthritis 30.0 VEGFA TTR TGFB1 IL6 IL1B
9 diabetic neuropathy 30.0 VEGFA PMP22 INS
10 dupuytren contracture 30.0 IL1B TGFB1 VEGFA
11 osteoarthritis 29.9 ACAN IL1B IL6 TGFB1
12 interstitial lung disease 29.7 IL1B IL6 TGFB1
13 peritonitis 29.7 B2M IL1B IL6
14 extramedullary plasmacytoma 29.6 B2M IL6
15 sleep apnea 29.6 IL1B IL6 INS
16 brain edema 29.5 VEGFA IL6 IL1B
17 arteries, anomalies of 29.5 VEGFA INS IL6 IL1B
18 pneumoconiosis 29.5 TGFB1 IL6 IL1B
19 al amyloidosis 29.5 B2M TTR
20 prostatitis 29.4 TGFB1 IL6 IL1B
21 kidney disease 29.4 TTR TGFB1 INS IL6 B2M
22 bone disease 29.4 IL6 IL1B B2M ACAN
23 poems syndrome 29.4 VEGFA IL6 IL1B
24 spinal disease 29.3 IL6 VEGFA
25 acquired immunodeficiency syndrome 29.3 B2M IL1B IL6
26 esophagitis 29.3 TGFB1 IL6 IL1B
27 osteonecrosis of the jaw 29.3 TGFB1 VEGFA
28 paraneoplastic syndromes 29.3 IL1B IL6
29 meningoencephalitis 29.2 TAC1 IL6 B2M
30 endometriosis 29.1 IL1B IL6 VEGFA
31 asthma 29.1 IL1B IL6 INS TAC1 TGFB1
32 bone inflammation disease 29.0 IL6 IL1B ACAN
33 fatty liver disease 29.0 IL1B IL6 INS
34 amyloid tumor 29.0 B2M TTR
35 ewing sarcoma 29.0 IL1B IL6 INS TGFB1 VEGFA
36 tendinopathy 29.0 COL5A1 VEGFA
37 periapical periodontitis 28.9 IL1B IL6
38 intestinal disease 28.9 IL1B IL6 VEGFA
39 leishmaniasis 28.9 IL1B IL6 TGFB1
40 chagas disease 28.7 IL1B IL6 TGFB1
41 cytomegalovirus infection 28.7 B2M IL1B IL6
42 central nervous system disease 28.6 IL1B IL6 TTR
43 bronchial disease 28.6 TAC1 IL6 IL1B
44 chronic kidney failure 28.3 TTR TGFB1 INS IL6 B2M
45 nervous system disease 28.1 VEGFA TTR INS IL6 IL1B
46 mononeuropathy of the median nerve, mild 12.4
47 acromegaly 11.5
48 neuropathy, hereditary, with liability to pressure palsies 11.5
49 overuse syndrome 11.5
50 paresthesia 11.5

Graphical network of the top 20 diseases related to Carpal Tunnel Syndrome:

Diseases related to Carpal Tunnel Syndrome

Symptoms & Phenotypes for Carpal Tunnel Syndrome

Symptoms via clinical synopsis from OMIM:

constrictive median neuropathy
tunnel sign

responsive to pyridoxine administration
early onset age

thickened transverse carpal ligament
digital flexor tenosynovitis

vitamin b6 deficiency

Clinical features from OMIM:


Human phenotypes related to Carpal Tunnel Syndrome:

# Description HPO Frequency HPO Source Accession
1 peripheral neuropathy 32 HP:0009830
2 constrictive median neuropathy 32 HP:0012185
3 digital flexor tenosynovitis 32 HP:0012276
4 vitamin b6 deficiency 32 HP:0008326

UMLS symptoms related to Carpal Tunnel Syndrome:

seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, muscle cramp

MGI Mouse Phenotypes related to Carpal Tunnel Syndrome:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 B2M COL5A1 IL1B IL6 INS SH3TC2
2 homeostasis/metabolism MP:0005376 10.13 B2M BGN IL1B IL6 INS PMP22
3 growth/size/body region MP:0005378 10.11 B2M BGN COL5A1 IL1B IL6 INS
4 mortality/aging MP:0010768 10.07 B2M BGN COL5A1 IL1B IL6 INS
5 integument MP:0010771 10.06 B2M BGN COL5A1 IL1B IL6 INS
6 digestive/alimentary MP:0005381 9.95 B2M IL6 INS TGFB1 TTR VEGFA
7 muscle MP:0005369 9.87 BGN IL6 INS PMP22 SH3TC2 TGFB1
8 renal/urinary system MP:0005367 9.73 IL6 INS TAC1 TGFB1 TTR VEGFA
9 reproductive system MP:0005389 9.7 B2M BGN IL6 INS PMP22 TGFB1
10 skeleton MP:0005390 9.5 BGN IL1B IL6 INS SH3TC2 TGFB1
11 vision/eye MP:0005391 9.17 COL5A1 IL6 INS PMP22 TGFB1 TTR

Drugs & Therapeutics for Carpal Tunnel Syndrome

PubMedHealth treatment related to Carpal Tunnel Syndrome: 63

Mild to moderate carpal tunnel syndrome can usually be treated with a splint at first. The splint is worn at night to prevent the wrist from bending too far. Doctors may also advise you to avoid activities thought to be related to this condition.Injecting corticosteroids into the carpal tunnel can provide temporary relief, but corticosteroid injections aren't an effective long-term solution.Surgery may also be considered as a treatment. During the operation, the flexor retinaculum that arches across the base of the hand is cut: to reduce pressure on the median nerve. This procedure can make the symptoms go away for good, but it's not always necessary. Other treatments are usually preferred, especially in early stages of the condition. Immediate surgery is only needed in very rare cases of acute carpal tunnel syndrome.Other treatments such as acupuncture, ultrasound therapy, laser therapy or magnetic field therapy may also be recommended. But there is no evidence that they are effective in the treatment of carpal tunnel syndrome.Many people take painkillers to relieve their symptoms – particularly non-steroidal anti-inflammatory drugs (NSAIDs), which are available over-the-counter at pharmacies and drugstores. Taking vitamin B6 products is sometimes also recommended to strengthen the nerves. So far, though, research suggests that neither NSAIDs nor vitamin B6 can provide enough pain relief.

Drugs for Carpal Tunnel Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 50-24-8 5755
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 302-25-0
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 2921-57-5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 83-43-2 6741
Bupivacaine Approved, Investigational Phase 4,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
7 tannic acid Approved Phase 4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
Vancomycin Approved Phase 4 1404-90-6 14969 441141
Cefazolin Approved Phase 4 25953-19-9 656510 33255
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3 56-12-2 119
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 2920-86-7
26 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
27 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
29 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
30 Autonomic Agents Phase 4,Phase 2,Phase 3,Not Applicable
31 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
33 Antiemetics Phase 4,Phase 2,Phase 3,Not Applicable
34 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
35 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable
39 Methylprednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
40 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
41 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
43 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
46 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Respiratory System Agents Phase 4,Phase 3,Not Applicable
48 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
50 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 218)
# Name Status NCT ID Phase Drugs
1 Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
2 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration Active, not recruiting NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
3 Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome Completed NCT02140632 Phase 4
4 Length of Post Operative Dressing After Carpal Tunnel Release Completed NCT01310218 Phase 4
5 Injection Versus Splinting in Carpal Tunnel Syndrome Active, not recruiting NCT02038452 Phase 4 Depo-Medrone
6 Preoperative Antibiotics for Carpal Tunnel Release Surgery Not yet recruiting NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
7 Comparison of the Efficacy of Corticosteroid Injection and ESWT in Patients With CTS Not yet recruiting NCT03792945 Phase 4 local injection
8 Postoperative Alpha Lipoic Acid in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
9 Myofascial Release on Electrophysiological Measures of Pregnant Women With CTS Completed NCT03802448 Phase 4
10 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome Completed NCT00277563 Phase 4
11 Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
12 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
13 Narcotic vs. Non-narcotic Pain Study Protocol Recruiting NCT01974609 Phase 4 Narcotic;non-narcotic
14 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
15 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
16 Onset and Duration of Forearm Nerve Blockade Recruiting NCT03649763 Phase 4 Lidocaine;Bupivacaine;Lidocaine
17 Distribution Circumferential Versus Non Circumferential of Mepivacaine in the Median and Ulnar Nerves Completed NCT01603680 Phase 4
18 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
19 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery Terminated NCT02029235 Phase 4 Acetaminophen/Ibuprofen;Acetaminophen/Hydrocodone
20 Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture Recruiting NCT03749616 Phase 4 Ibuprofen;Acetaminophen
21 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
22 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Unknown status NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
23 Carpal Tunnel Syndrome Release Using PSU Retractor Unknown status NCT01017471 Phase 3
24 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
25 Gabapentin for Carpal Tunnel Syndrome Completed NCT00137735 Phase 3 Gabapentin
26 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
27 Steroid Injection Treatment of Carpal Tunnel Syndrome Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
28 Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
29 Preoperative Gabapentine for Carpal Tunnel Completed NCT01632215 Phase 3 Gabapentine
30 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
31 A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
32 Efficacy/Safety of Octreotide Acetate in Patients With Uncontrolled Acromegaly Completed NCT00372697 Phase 3 Octreotide acetate 30 mg suspension
33 Assessment of 18F-Florbetaben Whole-body PET for the Detection of Cardiac and Extracardiac Sites of Amyloid Deposits Not yet recruiting NCT03616496 Phase 2, Phase 3 Neuraceq 300MBq/mL Solution for Injection for PET imaging
34 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
35 Carpal Tunnel Syndrome Treated With 830nm Diode Laser Unknown status NCT00514462 Phase 1, Phase 2
36 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
37 A Pilot Study to Evaluate the Effectiveness of Ultrasound Guided Looped Thread Carpal Tunnel Release Completed NCT03476486 Phase 2
38 Fascial Manipulation on the Treatment of Carpal Tunnel Syndrome Completed NCT02495298 Phase 2
39 Botulinum Toxin for Carpal Tunnel Syndrome Active, not recruiting NCT00701233 Phase 2 Botulinum toxin;Corticosteroid injection into Carpal Tunnel
40 Alpha Lipoic Acid on Clinical and Electrophysiological Recovery in Carpal Tunnel Syndrome Undergoing Surgical Release Completed NCT02382328 Phase 2 alpha lipoic acid;Placebo
41 Percutaneous Treatment of Carpal Tunnel Syndrome With Scan Completed NCT02514317 Phase 2
42 The Treatment of the Median Nerve for the Elimination of the Symptoms Associated With the Carpal Tunnel Syndrome Completed NCT00634738 Phase 1, Phase 2
43 Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome Completed NCT00991068 Phase 2 Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch
44 Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome Completed NCT01093209 Phase 2
45 Treatment Efficacy of OMT for Carpal Tunnel Syndrome Completed NCT00394043 Phase 2
46 BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome Completed NCT02070302 Phase 2 Botulinum Toxin Type A;Placebo
47 The Treatment of Carpal Tunnel Syndrome Using Thumb Pressure Along the Median Nerve Completed NCT00634699 Phase 1, Phase 2
48 Acupuncture for Carpal Tunnel Syndrome Completed NCT00000394 Phase 2
49 Mechanisms of Neural Mobilization in the Treatment of Chronic Pain Completed NCT00929123 Phase 1, Phase 2
50 Influence of Pronator Teres Release on Treatment of Median Nerve Compression Neuropathy Recruiting NCT01562860 Phase 2

Search NIH Clinical Center for Carpal Tunnel Syndrome

Cochrane evidence based reviews: carpal tunnel syndrome

Genetic Tests for Carpal Tunnel Syndrome

Genetic tests related to Carpal Tunnel Syndrome:

# Genetic test Affiliating Genes
1 Carpal Tunnel Syndrome 29 TTR

Anatomical Context for Carpal Tunnel Syndrome

MalaCards organs/tissues related to Carpal Tunnel Syndrome:

Testes, Bone, Thyroid, Skin, Breast, Brain, Kidney

Publications for Carpal Tunnel Syndrome

Articles related to Carpal Tunnel Syndrome:

(show top 50) (show all 1864)
# Title Authors Year
AAOS Appropriate Use Criteria: Management of Carpal Tunnel Syndrome. ( 29432365 )
Carpal tunnel syndrome prevalence: an evaluation of workers at a raw poultry processing plant. ( 29873286 )
Occurrence of bifid median nerve in healthy and carpal tunnel syndrome patients. ( 29413456 )
A prognostic model for the patient reported outcome of surgical treatment of carpal tunnel syndrome. ( 29981160 )
Diagnosis and Treatment of Carpal Tunnel Syndrome in Low-prevalence Circumstances. ( 29952784 )
Topiramate-induced Neuropathy Mimicking Carpal Tunnel Syndrome: A Case Report. ( 29430500 )
What types of treatment are provided for patients with Carpal Tunnel Syndrome? A retrospective analysis of commercial insurance. ( 29452295 )
Management of Carpal Tunnel Syndrome. ( 29420323 )
Ultrasonography for the Diagnosis of Carpal Tunnel Syndrome in Diabetic Patients: Missing the Mark? ( 29966141 )
Are Carpal Tunnel Syndrome and Regional Degenerative Osteoarthritis Linked? Results of a Case-Control Study. ( 29409410 )
Effect of Alpha-Lipoic Acid on Clinical and Neurophysiologic Recovery of Carpal Tunnel Syndrome: A Double-Blind, Randomized Clinical Trial. ( 29356576 )
Intrasynovial spindle cell lipoma of the deep flexor of the middle finger causing intermittent carpal tunnel syndrome-case report and review of the literature. ( 29429014 )
Median nerve ultrasound in carpal tunnel syndrome with normal electrodiagnostic tests. ( 29949031 )
Comparison of splinting and Kinesio taping in the treatment of carpal tunnel syndrome: a prospective randomized study. ( 29948355 )
Bilateral carpal tunnel syndrome - A review. ( 28992938 )
Carpal tunnel syndrome after an electrical injury: a case report and review of literature. ( 29899196 )
Ultrasound carpal tunnel syndrome: additional criteria for diagnosis. ( 28859853 )
Effect of Polydeoxyribonucleotide Injection in a Patient with Carpal Tunnel Syndrome: A Case Report. ( 29373371 )
Carpal Tunnel Syndrome: Evaluation of the Effects of Low-Level Laser Therapy With Ultrasound Strain Imaging. ( 29892976 )
A Prospective Comparison of Diagnostic Tools for the Diagnosis of Carpal Tunnel Syndrome. ( 29935774 )
Sonographic assessment of carpal tunnel syndrome in diabetic patients with and without polyneuropathy. ( 29901629 )
Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: a prospective randomized controlled trial. ( 29370788 )
Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trial. ( 29433485 )
Translation and Validation of the Persian Version the Boston Carpal Tunnel Syndrome Questionnaire. ( 29430499 )
Diffusion tensor imaging findings of the median nerve before and after carpal tunnel corticosteroid injection in patients with carpal tunnel syndrome: a preliminary study. ( 29979105 )
Author Correction to: L-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome: Effects on Nerve Protection, Hand Function and Pain. ( 29441455 )
Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records. ( 29921681 )
Thumb Opposition Recovery Following Surgery for Severe Carpal Tunnel Syndrome: A Clinical, Radiological, and Electrophysiological Pilot Study. ( 29934085 )
Short-term clinical outcome of orthosis alone vs combination of orthosis, nerve, and tendon gliding exercises and ultrasound therapy for treatment of carpal tunnel syndrome. ( 29426574 )
The effectiveness of splinting and surgery on sleep disturbance in carpal tunnel syndrome. ( 28872412 )
Diagnosis of carpal tunnel syndrome. ( 29894306 )
A Median Nerve Anterior Transposition Procedure for Multi-Recurrent Hemodialysis-Related Carpal Tunnel Syndrome. ( 29409425 )
Effectiveness of ultrasound-guided vs direct approach corticosteroid injections for carpal tunnel syndrome: A double-blind randomized controlled trial. ( 29355292 )
Mental and Physical Health Disparities in Patients With Carpal Tunnel Syndrome Living With High Levels of Social Deprivation. ( 29945843 )
Different doses of steroid injection in elderly patients with carpal tunnel syndrome: a triple-blind, randomized, controlled trial. ( 29403268 )
Efficacy of dietary supplement with nutraceutical composed combined with extremely-low-frequency electromagnetic fields in carpal tunnel syndrome. ( 29950763 )
Carpal Tunnel Syndrome Caused by Intraneural Lipoma of the Median Nerve and Arteriovenous Malformation. ( 29731590 )
Arthropathy-like findings and a carpal tunnel syndrome as the presenting features of Scheie syndrome: Three cases from the same family. ( 30511553 )
Carpal Tunnel Syndrome and Flexor Tendon Rupture in the Wrist with Asymptomatic Scapholunate Advanced Collapse: A Case Report. ( 30428801 )
Which Factors Affect the Rate of Surgery Performed in Patients with Carpal Tunnel Syndrome? ( 30428804 )
Modeling Nerve Compression in Carpal Tunnel Syndrome. ( 30441668 )
Clinical relevance commentary in response to: Intrarater and inter-rater reliability of a handheld dynamometric technique to quantify palmar thumb abduction strength in individuals with and without carpal tunnel syndrome. ( 30449388 )
Observational pilot study of patients with carpal tunnel syndrome treated with Nucleo CMP Forte™. ( 30451573 )
Ultrasound, Clinical, and Electrophysiological Findings in Persistent Carpal Tunnel Syndrome. ( 30468290 )
Revision surgery in carpal tunnel syndrome: a retrospective study comparing the Canaletto® device alone versus a combination of Canaletto® and Dynavisc® gel. ( 30472072 )
Comments on "Utilization of Electrodiagnostic Testing for Carpal Tunnel Syndrome by General Practitioners Prior to Hand Surgery Consultation". ( 30486676 )
The Association Between Concomitant Ulnar Nerve Compression at the Elbow and Carpal Tunnel Syndrome. ( 30499347 )
Cost-Effectiveness Evaluation of Manual Physical Therapy Versus Surgery for Carpal Tunnel Syndrome: Evidence From a Randomized Clinical Trial. ( 30501389 )
Carpal Tunnel Syndrome: Retrospective Analysis of 60 Consecutive Cases of Ambulatory Surgical Treatment With Local Anesthesia. ( 30501506 )

Variations for Carpal Tunnel Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Carpal Tunnel Syndrome:

# Symbol AA change Variation ID SNP ID
1 TTR p.Tyr134His VAR_007598 rs121918088

ClinVar genetic disease variations for Carpal Tunnel Syndrome:

# Gene Variation Type Significance SNP ID Assembly Location
1 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh37 Chromosome 18, 29178618: 29178618
2 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh38 Chromosome 18, 31598655: 31598655
3 TTR NM_000371.3(TTR): c.400T> C (p.Tyr134His) single nucleotide variant Pathogenic rs121918088 GRCh37 Chromosome 18, 29178594: 29178594
4 TTR NM_000371.3(TTR): c.400T> C (p.Tyr134His) single nucleotide variant Pathogenic rs121918088 GRCh38 Chromosome 18, 31598631: 31598631
5 TTR NM_000371.3(TTR): c.122G> A (p.Arg41Gln) single nucleotide variant Uncertain significance rs879254269 GRCh38 Chromosome 18, 31592948: 31592948
6 TTR NM_000371.3(TTR): c.122G> A (p.Arg41Gln) single nucleotide variant Uncertain significance rs879254269 GRCh37 Chromosome 18, 29172911: 29172911

Expression for Carpal Tunnel Syndrome

Search GEO for disease gene expression data for Carpal Tunnel Syndrome.

Pathways for Carpal Tunnel Syndrome

Pathways related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
5 11.99 IL1B IL6 TAC1 VEGFA
Show member pathways
11.95 IL6 INS TGFB1
7 11.93 IL6 INS TGFB1
Show member pathways
11.92 IL1B IL6 TGFB1
Show member pathways
11.9 ACAN IL1B IL6
10 11.88 IL6 INS TGFB1 VEGFA
11 11.78 IL6 INS VEGFA
12 11.78 ACAN IL1B IL6 TGFB1
13 11.76 IL1B IL6 TGFB1
14 11.73 IL1B IL6 TGFB1 VEGFA
15 11.65 IL1B IL6 INS TGFB1
16 11.64 IL1B IL6 TGFB1
17 11.6 IL1B IL6 TGFB1
19 11.55 IL1B IL6 TGFB1 VEGFA
20 11.53 IL1B IL6 TGFB1
Show member pathways
11.52 IL1B IL6 VEGFA
22 11.47 ACAN BGN TGFB1
23 11.41 IL1B IL6 TGFB1 VEGFA
24 11.39 IL6 TGFB1 VEGFA
25 11.36 IL1B IL6 TGFB1
26 11.07 IL1B IL6 TGFB1
27 10.88 ACAN COL5A1 IL1B IL6 TGFB1
28 10.61 IL6 INS TGFB1 VEGFA

GO Terms for Carpal Tunnel Syndrome

Cellular components related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.67 B2M COL5A1 IL6 INS
2 extracellular matrix GO:0031012 9.65 ACAN BGN COL5A1 TGFB1 VEGFA
3 collagen-containing extracellular matrix GO:0062023 9.62 ACAN BGN COL5A1 TGFB1
4 extracellular space GO:0005615 9.61 B2M COL5A1 IL1B IL6 INS TAC1
5 secretory granule GO:0030141 9.58 IL1B TGFB1 VEGFA
6 Golgi lumen GO:0005796 9.46 ACAN BGN INS TGFB1
7 extracellular region GO:0005576 9.36 ACAN B2M BGN COL5A1 IL1B IL6

Biological processes related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.92 IL1B IL6 PMP22 TGFB1
2 inflammatory response GO:0006954 9.88 IL1B IL6 TAC1 TGFB1
3 positive regulation of cell proliferation GO:0008284 9.85 IL1B IL6 INS TGFB1 VEGFA
4 cytokine-mediated signaling pathway GO:0019221 9.81 IL1B IL6 TGFB1 VEGFA
5 positive regulation of cell migration GO:0030335 9.73 IL1B INS TGFB1 VEGFA
6 wound healing GO:0042060 9.7 IL1B INS TGFB1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 IL6 TGFB1 VEGFA
8 cellular protein metabolic process GO:0044267 9.67 B2M IL6 INS TTR
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.65 IL6 TGFB1 VEGFA
10 positive regulation of gene expression GO:0010628 9.65 IL1B IL6 INS TGFB1 VEGFA
11 extracellular matrix organization GO:0030198 9.62 ACAN BGN COL5A1 TTR
12 positive regulation of protein autophosphorylation GO:0031954 9.61 INS VEGFA
13 response to vitamin D GO:0033280 9.61 IL1B TGFB1
14 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.6 TGFB1 VEGFA
15 positive regulation of histone acetylation GO:0035066 9.59 IL1B TGFB1
16 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.58 IL1B VEGFA
17 negative regulation of lipid catabolic process GO:0050995 9.57 IL1B INS
18 positive regulation of cellular protein metabolic process GO:0032270 9.56 INS TGFB1
19 positive regulation of glial cell proliferation GO:0060252 9.55 IL1B IL6
20 positive regulation of acute inflammatory response GO:0002675 9.54 IL6 TAC1
21 positive regulation of neuroinflammatory response GO:0150078 9.4 IL1B IL6
22 positive regulation of cell division GO:0051781 9.33 IL1B TGFB1 VEGFA
23 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.26 IL1B IL6 INS TGFB1
24 regulation of signaling receptor activity GO:0010469 9.1 IL1B IL6 INS TGFB1 TTR VEGFA

Molecular functions related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.33 ACAN BGN COL5A1
2 extracellular matrix structural constituent conferring compression resistance GO:0030021 8.96 ACAN BGN
3 cytokine activity GO:0005125 8.92 IL1B IL6 TGFB1 VEGFA

Sources for Carpal Tunnel Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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