CTS1
MCID: CRP001
MIFTS: 66

Carpal Tunnel Syndrome (CTS1)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Neuronal diseases
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Aliases & Classifications for Carpal Tunnel Syndrome

MalaCards integrated aliases for Carpal Tunnel Syndrome:

Name: Carpal Tunnel Syndrome 57 11 42 52 75 28 53 5 41 43 14 63 38 16 71 31 33
Carpal Tunnel Syndrome, Familial 57 12 38 71
Cts 57 42 73 16
Carpal Tunnel Syndrome 1 73 28 5
Amyotrophy, Thenar, of Carpal Origin 57 42
Cts1 57 73
Compression Neuropathy, Carpal Tunnel 42
Entrapment Neuropathy, Carpal Tunnel 42
Thenar Amyotrophy of Crapal Origin 73
Median Neuropathy, Carpal Tunnel 42
Carpal Tunnel Median Neuropathy 11
Distal Median Nerve Compression 42
Median Neuropathy Carpal Tunnel 73
Distal Median Nerve Entrapment 42
Cts - Carpal Tunnel Syndrome 11
Median Nerve Entrapment 11
Carpal Tunnel 42
Carpal Canal 42

Characteristics:


Inheritance:

Autosomal dominant 57

OMIM®:

57 (Updated 08-Dec-2022)
Miscellaneous:
age of onset in sixth decade of life


Classifications:



External Ids:

Disease Ontology 11 DOID:12169
OMIM® 57 115430
OMIM Phenotypic Series 57 PS115430
ICD9CM 34 354.0
MeSH 43 D002349
NCIt 49 C34450
SNOMED-CT 68 193126005
ICD10 31 G56.0
MedGen 40 C0007286
ICD11 33 1275186848
UMLS 71 C0007286 C3468338

Summaries for Carpal Tunnel Syndrome

MedlinePlus Genetics: 42 Carpal tunnel syndrome is a disorder caused by disturbances in nerve function (neuropathy), leading to pain and numbness or tingling (paresthesia) primarily in the wrist and hand. While carpal tunnel syndrome can occur at any age, it most often affects people between the ages of 40 and 60. In more than half of cases, both hands are affected; however, the severity may vary between hands. When only one hand is affected, it is most often the hand used for writing (the dominant hand).In carpal tunnel syndrome, the pain or paresthesia is usually felt in the wrist, the palm, and the first four fingers of the hand. These signs and symptoms often develop during sleep and are noticeable upon waking. Affected individuals typically shake their hand to get rid of the pain and numbness, a characteristic move known as the flick sign. As the condition advances, the signs and symptoms begin to occur during the day as well. Affected individuals may have difficulty performing manual tasks such as turning doorknobs, fastening buttons, or opening jars. The symptoms of carpal tunnel syndrome may be triggered by certain activities that flex or extend the wrist, such as driving, typing, or holding a telephone.Over time, people with carpal tunnel syndrome can have muscle and nerve wasting (atrophy) in the affected hand and a reduced ability to detect sensations, which can be mistaken for an improvement of symptoms.

MalaCards based summary: Carpal Tunnel Syndrome, also known as carpal tunnel syndrome, familial, is related to neuropathy, hereditary, with liability to pressure palsies and amyloidosis, and has symptoms including tremor, back pain and headache. An important gene associated with Carpal Tunnel Syndrome is TTR (Transthyretin), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Gabapentin and Nimodipine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, skin and bone, and related phenotypes are peripheral neuropathy and constrictive median neuropathy

MedlinePlus: 41 You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. Suddenly, a sharp, piercing pain shoots through the wrist and up your arm. Just a passing cramp? It could be carpal tunnel syndrome. The carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. It contains nerve and tendons. Sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. Symptoms usually start gradually. As they worsen, grasping objects can become difficult. Often, the cause is having a smaller carpal tunnel than other people do. Other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. Women are three times more likely to have carpal tunnel syndrome than men. Early diagnosis and treatment are important to prevent permanent nerve damage. Your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. Treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

PubMed Health : 63 Carpal tunnel syndrome: Most people's hands briefly "fall asleep" every now and then. They then feel numb or tingly. Although this is a little unpleasant, it's usually over very quickly. Carpal tunnel syndrome has similar symptoms – but they keep coming back again and are often painful. The carpal tunnel is a passageway inside of the wrist that is surrounded by bones and connective tissue. It runs along the inner side of the wrist to the base of the hand and is covered by a strong, fibrous band made up of connective tissue, called the flexor retinaculum. The carpal tunnel contains tendons and the median nerve. This nerve is responsible for sensation and movement in the ball of the thumb and some parts of the hand. If the tissue inside the carpal tunnel swells up, it can put pressure on the median nerve, which is what causes carpal tunnel syndrome. The symptoms often go away on their own, but they can sometimes last for quite a long time. There are a number of different treatments that can provide relief.

NINDS: 52 Carpal tunnel syndrome (CTS) occurs when  the median nerve, which runs from the forearm into the palm of the hand,  becomes pressed or squeezed at the wrist. The carpal tunnel is a narrow, rigid passageway of ligament and bones at the base of the hand that houses the median nerve and the tendons that bend the fingers. The median nerve provides feeling to the palm side of the thumb and to most of the fingers. Symptoms usually start gradually, with numbness, tingling, hand weakness, and sometimes pain in the hand and wrist.  CTS makes it difficult for some people to drive, read a book, grasp small objects, or do other tasks. Sometimes no direct cause of CTS can be found; contributing factors include trauma or injury to the wrist that causes swelling, as well as thyroid disease, rheumatoid arthritis, and fluid retention during pregnancy. Women are three times more likely than men to develop carpal tunnel syndrome. The disorder usually occurs only in adults.

UniProtKB/Swiss-Prot: 73 A condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.

OMIM®: 57 Carpal tunnel syndrome-1 (CTS1) is characterized by hand pain and numbness in the distribution of the median nerve, with onset in the sixth decade of life. Amyloid deposits are observed in synovial tissue of the wrist and in the transverse carpal ligament (Murakami et al., 1994). (115430) (Updated 08-Dec-2022)

Wikipedia: 75 Carpal tunnel syndrome (CTS) is the collection of symptoms and signs associated with median neuropathy... more...

Related Diseases for Carpal Tunnel Syndrome

Diseases in the Carpal Tunnel Syndrome family:

Carpal Tunnel Syndrome 2

Diseases related to Carpal Tunnel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 994)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary, with liability to pressure palsies 32.6 SH3TC2 PMP22 MPZ
2 amyloidosis 32.2 TTR INS IL6 IL1B B2M
3 radiculopathy 32.1 TAC1 IL6 CCL2 ACAN
4 temporal arteritis 31.9 VEGFA IL6 IL1B CCL2 ACE
5 median neuropathy 31.8 TTR PMP22
6 polyneuropathy 31.5 TTR SH3TC2 PMP22 MPZ
7 ulnar neuropathy 31.5 PMP22 MPZ
8 neuropathy 31.4 VEGFA SH3TC2 PMP22 MPZ ACE
9 complex regional pain syndrome 31.2 TAC1 IL6 IL1B
10 microvascular complications of diabetes 1 31.0 VEGFA INS CCN2 CCL2
11 nerve compression syndrome 31.0 TTR TAC1 SH3TC2 PSMD9 PMP22 MPZ
12 paine syndrome 31.0 TAC1 IL6 IL1B COL5A1
13 diabetic polyneuropathy 31.0 VEGFA TAC1 INS IL6 GAP43
14 fibromyalgia 30.9 INS IL6 IL1B CCL2
15 osteoarthritis 30.9 TGFB1 IL6 IL1B COMP ACAN
16 synovitis 30.9 VEGFA IL6 IL1B COMP CCL2 ACAN
17 arthropathy 30.8 IL6 IL1B COMP B2M ACAN
18 mononeuropathy 30.8 TTR TAC1 SH3TC2 PMP22 MPZ IL6
19 serum amyloid a amyloidosis 30.8 TTR IL6 B2M
20 epicondylitis 30.8 VEGFA TGFB1 TAC1 COL5A1 ACAN
21 leprosy 3 30.7 IL6 IL1B CCL2
22 bursitis 30.7 TAC1 IL6 IL1B
23 spondylosis 30.7 TAC1 IL6 IL1B ACAN
24 sarcoidosis 1 30.7 TAC1 IL6 IL1B CCL2 ACE
25 diabetic neuropathy 30.7 VEGFA TAC1 PMP22 MPZ INS ACE
26 tendinitis 30.6 VEGFA TAC1 IL6 IL1B COMP ACAN
27 systemic scleroderma 30.6 VEGFA IL6 IL1B CCN2 CCL2 ACE
28 neuritis 30.5 VEGFA PMP22 MPZ IL6 IL1B CCL2
29 microvascular complications of diabetes 3 30.5 TGFB1 INS CCN2 ACE
30 exanthem 30.5 VEGFA IL6 IL1B ACE
31 sleep disorder 30.5 TAC1 INS IL6 IL1B ACE
32 impotence 30.5 VEGFA TGFB1 TAC1 ACE
33 lipid metabolism disorder 30.5 INS IL6 IL1B CCL2 ACE
34 roussy-levy hereditary areflexic dystasia 30.4 PMP22 MPZ
35 microvascular complications of diabetes 5 30.4 VEGFA INS CCN2 ACE
36 type 1 diabetes mellitus 30.4 VEGFA INS IL6 IL1B B2M ACE
37 alcohol use disorder 30.4 INS IL6 IL1B ACE
38 contact dermatitis 30.4 TAC1 IL6 IL1B
39 chikungunya 30.4 IL6 IL1B CCL2
40 spondyloarthropathy 30.4 IL6 IL1B B2M ACAN
41 demyelinating polyneuropathy 30.4 TTR SH3TC2 PMP22 MPZ IL6
42 psoriatic arthritis 30.4 VEGFA IL6 IL1B COMP
43 arthritis 30.4 TTR IL6 IL1B COMP CCL2 B2M
44 charcot-marie-tooth disease, demyelinating, type 1a 30.3 SH3TC2 PMP22 MPZ
45 sensory peripheral neuropathy 30.3 TAC1 SH3TC2 PMP22 MPZ
46 osteonecrosis 30.3 VEGFA TGFB1 ESR1
47 uremia 30.3 INS IL6 IL1B B2M ACE
48 cellulitis 30.3 INS IL6 IL1B
49 eclampsia 30.3 VEGFA IL6 ACE
50 peripheral nervous system disease 30.3 VEGFA TTR TAC1 SH3TC2 PMP22 MPZ

Graphical network of the top 20 diseases related to Carpal Tunnel Syndrome:



Diseases related to Carpal Tunnel Syndrome

Symptoms & Phenotypes for Carpal Tunnel Syndrome

Human phenotypes related to Carpal Tunnel Syndrome:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 peripheral neuropathy 30 HP:0009830
2 constrictive median neuropathy 30 HP:0012185
3 reduced circulating vitamin b6 level 30 HP:0008326
4 digital flexor tenosynovitis 30 HP:0012276

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Muscle Soft Tissue:
thenar atrophy
amyloid deposits in synovial tissue
amyloid deposits in transverse carpal ligament

Neurologic Peripheral Nervous System:
median nerve compression in carpal tunnel
pain in thumb, index, and middle fingers
paresthesias in thumb, index, and middle fingers
numbness in thumb, index, and middle fingers
absent motor response to electrical stimulation of median nerve
more

Clinical features from OMIM®:

115430 (Updated 08-Dec-2022)

UMLS symptoms related to Carpal Tunnel Syndrome:


tremor; back pain; headache; syncope; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; muscle cramp

GenomeRNAi Phenotypes related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 ACAN ACE B2M CCL2 CCN2 COL5A1
2 no effect GR00402-S-2 10.19 ACAN ACE B2M CCL2 CCN2 COL5A1

MGI Mouse Phenotypes related to Carpal Tunnel Syndrome:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.4 ACAN ACE B2M CCL2 CCN2 COMP
2 nervous system MP:0003631 10.36 ACAN B2M CCL2 ESR1 GAP43 IL1B
3 growth/size/body region MP:0005378 10.35 ACAN ACE B2M CCL2 CCN2 COL5A1
4 cardiovascular system MP:0005385 10.31 ACAN ACE B2M CCL2 CCN2 COL5A1
5 cellular MP:0005384 10.25 ACE B2M CCL2 CCN2 COMP ESR1
6 neoplasm MP:0002006 10.22 ACAN ACE B2M CCL2 ESR1 IL1B
7 muscle MP:0005369 10.22 ACAN CCL2 COMP ESR1 IL6 INS
8 normal MP:0002873 10.21 ACAN CCL2 CCN2 COL5A1 COMP ESR1
9 liver/biliary system MP:0005370 10.21 ACAN ACE B2M CCL2 CCN2 ESR1
10 behavior/neurological MP:0005386 10.18 ACAN ACE CCL2 COMP ESR1 IL6
11 digestive/alimentary MP:0005381 10.16 ACAN B2M CCL2 CCN2 ESR1 IL6
12 renal/urinary system MP:0005367 10.14 ACE ESR1 IL6 INS TAC1 TGFB1
13 immune system MP:0005387 10.1 ACAN ACE B2M CCL2 COMP ESR1
14 skeleton MP:0005390 10 ACAN CCL2 CCN2 COMP ESR1 IL1B
15 mortality/aging MP:0010768 9.86 ACAN ACE B2M CCL2 CCN2 COL5A1
16 vision/eye MP:0005391 9.85 CCL2 CCN2 COL5A1 GAP43 IL6 INS
17 integument MP:0010771 9.4 B2M CCL2 CCN2 COL5A1 ESR1 IL1B

Drugs & Therapeutics for Carpal Tunnel Syndrome

PubMed Health treatment related to Carpal Tunnel Syndrome: 63

Mild to moderate carpal tunnel syndrome can usually be treated with a splint at first. The splint is worn at night to prevent the wrist from bending too far. Doctors may also advise you to avoid activities thought to be related to this condition. Injecting corticosteroids into the carpal tunnel can provide temporary relief, but corticosteroid injections aren't an effective long-term solution. Surgery may also be considered as a treatment . During the operation , the flexor retinaculum that arches across the base of the hand is cut: to reduce pressure on the median nerve . This procedure can make the symptoms go away for good, but it's not always necessary. Other treatments are usually preferred, especially in early stages of the condition. Immediate surgery is only needed in very rare cases of acute carpal tunnel syndrome . Other treatments such as acupuncture , ultrasound therapy , laser therapy or magnetic field therapy may also be recommended. But there is no evidence that they are effective in the treatment of carpal tunnel syndrome . Many people take painkillers to relieve their symptoms – particularly non-steroidal anti-inflammatory drugs (NSAIDs), which are available over-the-counter at pharmacies and drugstores. Taking vitamin B6 products is sometimes also recommended to strengthen the nerves . So far, though, research suggests that neither NSAIDs nor vitamin B6 can provide enough pain relief.

Drugs for Carpal Tunnel Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Vancomycin Approved Phase 4 1404-90-6 14969
5
Cefazolin Approved Phase 4 25953-19-9 33255
6
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
7
Mepivacaine Approved, Vet_approved Phase 4 96-88-8, 1722-62-9 4062
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
11
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
12
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
13
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
14
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
15
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
16
Povidone K30 Approved, Experimental, Withdrawn Phase 4 9003-39-8 6917 131751496
17
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
18
Ibuprofen Approved Phase 4 15687-27-1 3672
19
Acetaminophen Approved Phase 4 103-90-2 1983
20
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 4 14838-15-4, 492-39-7 131954576 4786 26934
21
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
22
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
23
Arginine Approved, Investigational, Nutraceutical Phase 4 74-79-3 6322
24
Lipoic acid Approved, Investigational, Nutraceutical Phase 4 1200-22-2 864 6112
25
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8 5280382 445354
26
Cysteine Approved, Nutraceutical Phase 4 52-90-4 594 5862
27
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
28 Ibuprofen arginine Phase 4
29 Anesthetics, Local Phase 4
30 Anesthetics Phase 4
31 Alpha-lipoic Acid Phase 4
32 Anti-Arrhythmia Agents Phase 4
33 Sodium Channel Blockers Phase 4
34 Diuretics, Potassium Sparing Phase 4
35 Retinol palmitate Phase 4
36 Anti-Anxiety Agents Phase 4
37 Psychotropic Drugs Phase 4
38 Anticonvulsants Phase 4
39 Antibiotics, Antitubercular Phase 4
40 Anti-Bacterial Agents Phase 4
41
Ketorolac Tromethamine Phase 4
42
Methylprednisolone Acetate Phase 4 584547
43 Antioxidants Phase 4
44 Protective Agents Phase 4
45
Triamcinolone hexacetonide Phase 4
46
Triamcinolone diacetate Phase 4
47
Triamcinolone Acetonide Phase 4 6436
48 Antineoplastic Agents, Hormonal Phase 4
49 Neuroprotective Agents Phase 4
50 Antiemetics Phase 4

Interventional clinical trials:

(show top 50) (show all 357)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind, Cross-over Study of Lidocaine Patch 1.8% in Patients With Moderate to Severe Pain From Carpal Tunnel Syndrome Unknown status NCT04245371 Phase 4 Lidocaine 1.8%;Placebo
2 Oral Gabapentin Versus Control in the Treatment of Carpal Tunnel Syndrome Unknown status NCT04285281 Phase 4 Gabapentin oral capsules
3 Pain Reduction and Changes in Upper Limb Function Produced by Over the Counter Oral Ibuprofen Versus the Lack of Treatment, in Carpal Tunnel Syndrome. Unknown status NCT04328805 Phase 4 Ibuprofen tablets
4 Pain Reduction Produced by Physiotherapy, Ibuprofen, and the Absence of Treatment, in Carpal Tunnel Syndrome Unknown status NCT04119739 Phase 4 Ibuprofen
5 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration: Clinical Randomized Trial Unknown status NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
6 Pain Reduction and Changes in Upper Limb Function Produced by Physiotherapy, Ibuprofen Arginine, Gabapentin and the Absence of Treatment, in Carpal Tunnel Syndrome Unknown status NCT04025203 Phase 4 Ibuprofen Arginine;Gabapentin
7 The Association of Alpha Lipoic Acid to the Median Nerve Decompression in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
8 A Prospective Randomized Controlled Clinical Trial Comparing the Extracorporeal Shock Wave and Local Corticosteroid Injection for Carpal Tunnel Syndrome Completed NCT04767724 Phase 4
9 Local Steroid Injection vs Wrist Splinting for Carpal Tunnel Syndrome: A Randomized Clinical Trial Completed NCT02140632 Phase 4
10 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
11 Comparison of the Efficacy of Corticosteroid Injection and Extracorporeal Shock Wave Therapy (ESWT) in Patients With Carpal Tunnel Syndrome; A Prospective Randomized Controlled Trial Completed NCT03792945 Phase 4 local injection
12 Extended Follow-up of a Randomized Placebo-controlled Trial of Local Steroid Injection in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
13 Randomised, Multicentre, Open Label, Parallel Group Pragmatic Clinical Trial of Local Steroid Injection Versus Night Splinting in Mild to Moderate Carpal Tunnel Syndrome (CTS) Completed NCT02038452 Phase 4 Depo-Medrone
14 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome (Cts): A Randomized, Placebo-Controlled Trial With Secondary Bayesian Modification Completed NCT00277563 Phase 4
15 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
16 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
17 Onset and Duration of Forearm Nerve Blockade Performed With a Single Distal Injection Versus Sequential Injections at Distal and Proximal Locations Alongside the Nerves: A Blinded Randomized Completed NCT03649763 Phase 4 Lidocaine;Bupivacaine
18 Length of Postoperative Dressing After Mini-open Carpal Tunnel Release: A Randomized Prospective Comparison Completed NCT01310218 Phase 4
19 Bupivacaine Versus Lidocaine Local Anesthesia in Elective Outpatient Hand Surgery: A Randomized Controlled Trial Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
20 Endoscopic Carpal Tunnel Release, Infection Incidence, and Prophylactic Antibiotics: Indicated or Kick the Habit? Completed NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
21 A Randomized, Controlled Trial Comparing Combination Therapy of Ibuprofen + Acetaminophen Versus Hydrocodone + Acetaminophen for the Treatment of Pain After Carpal Tunnel Surgery Completed NCT01974609 Phase 4 Narcotic;non-narcotic
22 Comparing Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol Administration for Carpal Tunnel Release and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
23 Circumferential Versus Not Circumferential Distribution of Mepivacaine Around the Median and Ulnar Nerves in the Carpal Tunnel Surgery. Randomized Clinical Trial, Double Blinded. Completed NCT01603680 Phase 4
24 The NOR-CACTUS Trial - A Norwegian Trial Comparing Treatment Strategies for Carpal Tunnel Syndrome Recruiting NCT05306548 Phase 4 Injection, Triamcinolone Hexacetonide
25 The Use of N-acetylcysteine Supplementation in Addition to Night Splinting for Treatment of Mild to Moderate Carpal Tunnel Syndrome: A Randomized, Double-blind, Placebo-controlled Trial Recruiting NCT04460521 Phase 4 N-Acetyl cysteine
26 Comparison of the Efficacy of Different Treatment Methods in Patients With Carpal Tunnel Syndrome Recruiting NCT05475808 Phase 4 Wrist local steroid injection
27 The Therapeutic Effect and Quality of Life After Local Injection of Steroid VS. Glucose 5% for Carpal Tunnel Syndrome : Double-blinded Clinical Trial Recruiting NCT05496764 Phase 4 Dexamethasone;Glucose Injection
28 Randomized Controlled Trial of Ultrasound-guided Steroid Injection Versus Wrist Splint in Patients With Carpal Tunnel Syndrome Recruiting NCT04515966 Phase 4 Methylprednisolone Injection [Solu-Medrol]
29 Exparel and Education to Avoid Opioids After Carpal Tunnel Release Recruiting NCT03867539 Phase 4
30 Satisfaction With Pain Relief After Carpal Tunnel Release Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
31 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery: A Randomized, Double Blind Comparison of Acetaminophen/Ibuprofen Versus Acetaminophen/Hydrocodone Terminated NCT02029235 Phase 4 Acetaminophen/Ibuprofen;Acetaminophen/Hydrocodone
32 The Effect of Theraworx Foam on the Cross-sectional Area of the Median Nerve in Patients With Carpal Tunnel Syndrome Withdrawn NCT04017390 Phase 4 Theraworx Foam;Placebo Foam
33 Ultrasound-guided PRP Versus Steroid Injections in Management of Carpal Tunnel Syndrome; a Comparative Study Unknown status NCT04434105 Phase 2, Phase 3 platlet rich plasma (PRP);Triamcinolone Acetonide;Saline
34 Comparison of Local Steroid Injection With Platelet Rich Plasma in the Treatment of Carpal Tunnel Syndrome Unknown status NCT04000932 Phase 3 Local platelet rich plasma (PRP) injection-T-Lab PRP kit;Local steroid injection-Diprospan ®, Schering Plough
35 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Unknown status NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
36 Comparison Results of Carpal Tunnel Release Between Standard Incision and Limited Incision Using PSU Retractor: A Randomized Controlled Trial Unknown status NCT01017471 Phase 3
37 Local Steroid Injection in the Treatment of Idiopathic Carpal Tunnel Syndrome: A Randomized Double-blind Placebo-controlled Trial Among Patients Planned for Surgical Treatment Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
38 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
39 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial. Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
40 Gabapentin for Carpal Tunnel Syndrome: A Randomised Controlled Trial Completed NCT00137735 Phase 3 Gabapentin
41 Effect of Preoperative Gabapentine for Carpal Tunnel Syndrome Completed NCT01632215 Phase 3 Gabapentine
42 The Soft Tissue Injection of Corticosteroid And Local Anaesthetic Study - A Single Site, Non-inferiority Randomised Control Trial Evaluating Pain After Soft Tissue Corticosteroid Injections With and Without Local Anaesthetic Recruiting NCT04253457 Phase 3 1ml of triamcinolone (40mg/1ml)
43 A Randomized, Double-Blind Study Comparing the Safety and Efficacy of the Lidocaine Patch 5% With Placebo in Patients With Pain From Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
44 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
45 A Phase III, Randomized, Open-label Study to Assess the Safety and Efficacy of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
46 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
47 Instiutional Review Board of Chung Shan Medical University Hospital Unknown status NCT00514462 Phase 1, Phase 2
48 Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome, a Preliminary Study Completed NCT00634738 Phase 1, Phase 2
49 Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome: a Preliminary Study. Completed NCT00634699 Phase 1, Phase 2
50 Treatment Efficacy of OMT for Carpal Tunnel Syndrome Completed NCT00394043 Phase 2

Search NIH Clinical Center for Carpal Tunnel Syndrome

Cochrane evidence based reviews: carpal tunnel syndrome

Genetic Tests for Carpal Tunnel Syndrome

Genetic tests related to Carpal Tunnel Syndrome:

# Genetic test Affiliating Genes
1 Carpal Tunnel Syndrome 28
2 Carpal Tunnel Syndrome 1 28 TTR

Anatomical Context for Carpal Tunnel Syndrome

Organs/tissues related to Carpal Tunnel Syndrome:

MalaCards : Thyroid, Skin, Bone, Brain, Spinal Cord, Breast, Cortex

Publications for Carpal Tunnel Syndrome

Articles related to Carpal Tunnel Syndrome:

(show top 50) (show all 11768)
# Title Authors PMID Year
1
Familial carpal tunnel syndrome due to amyloidogenic transthyretin His 114 variant. 62 57 5
8309582 1994
2
DNA rearrangements on both homologues of chromosome 17 in a mildly delayed individual with a family history of autosomal dominant carpal tunnel syndrome. 53 62 57
9973284 1999
3
Familial carpal tunnel syndrome: further evidence for a genetic contribution. 62 57
16433699 2006
4
Hereditary neuropathy with liability to pressure palsies is not a major cause of idiopathic carpal tunnel syndrome. 62 57
11594922 2001
5
Is there a familial carpal tunnel syndrome? An evaluation and literature review. 62 57
9771681 1998
6
Autosomal dominant carpal tunnel syndrome. 62 57
9831348 1998
7
Mutilating hand syndrome in an infant with familial carpal tunnel syndrome. 62 57
9427229 1998
8
Familial carpal-tunnel syndrome presenting in childhood. Report of two cases. 62 57
3597507 1987
9
[Familial thenar amyotrophy of carpal origin]. 62 57
4089404 1985
10
Genetic linkage analysis of the carpal tunnel syndrome. 62 57
4043979 1985
11
Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. 62 57
6961425 1982
12
Familial bilateral carpal tunnel syndrome. 62 57
7241167 1981
13
Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome. 62 57
484522 1979
14
Primary familial bilateral carpal tunnel syndrome. 62 57
464452 1979
15
Survey and new data on treatment with pyridoxine of patients having a clinical syndrome including the carpal tunnel and other defects. 62 57
877401 1977
16
Familial carpal tunnel syndrome with onset in childhood. 62 57
1141922 1975
17
Carpal tunnel syndrome and trigger finger in childhood. 62 57
5773417 1969
18
CARPAL TUNNEL SYNDROME IN CHILDHOOD: REPORT OF A CASE. 62 57
14341079 1965
19
VOLCON: a randomized controlled trial investigating complications and functional outcome of volar plating vs casting of unstable distal radius fractures in patients older than 65 years. 62 41
36443579 2022
20
Dose- and time-dependent effects of collagenase clostridium histolyticum injection on transverse carpal ligament elastic modulus and thickness in vitro. 62 41
36454942 2022
21
Carpal tunnel volume distribution and morphology changes with flexion-extension and radial-ulnar deviation wrist postures. 62 41
36449537 2022
22
Familial occurrence of entrapment neuropathies. 57
444109 1979
23
Improved and effective assays of the glutamic oxaloacetic transaminase by the coenzyme-apoenzyme system (CAS) principle. 57
966077 1976
24
Human deficiencies of vitamin B6. I. Studies on parameters of the assay of the glutamic oxaloacetic transaminase by the CAS principle. 57
1197932 1975
25
Non-senile wild-type transthyretin systemic amyloidosis presenting as bilateral carpal tunnel syndrome. 53 62
18601659 2008
26
A new transthyretin variant (Glu61Gly) associated with cardiomyopathy. 53 62
17453626 2007
27
Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. 53 62
16266291 2005
28
Results of endoscopic management of primary versus recurrent carpal tunnel syndrome in long-term haemodialysis patients. 53 62
15810101 2004
29
Some implications of genetic biomarkers in occupational epidemiology and practice. 53 62
15018031 2004
30
Assessment of the scientific basis for genetic testing of railroad workers with carpal tunnel syndrome. 53 62
12802212 2003
31
A transthyretin mutation (Tyr78Phe) associated with peripheral neuropathy, carpal tunnel syndrome and skin amyloidosis. 53 62
12762139 2003
32
[Hereditary amyloidoses associated with transthyretin mutations]. 53 62
12376880 2002
33
Familial amyloid polyneuropathy in a Spanish family with a transthyretin deletion (deltaVal 122) presenting with carpal tunnel syndrome. 53 62
11140845 2000
34
[Metabolic and nutritional neuropathies]. 53 62
10853552 2000
35
[Amyloidosis and renal failure]. 53 62
10592739 1999
36
[Usefulness of magnetic resonance imaging of the wrist for the early diagnosis of dialysis-related amyloidosis]. 53 62
10077983 1999
37
Serum beta 2-microglobulin levels in patients chronically dialyzed with CA-210 versus CT-190 dialysis membranes. 53 62
9481434 1998
38
Apolipoprotein E and alpha 1-antichymotrypsin in dialysis-related amyloidosis. 53 62
9350687 1997
39
[Dynamic change of beta 2-microglobulin in hemodialysis]. 53 62
9387629 1996
40
Diagnostic aspects of beta 2-microglobulin amyloidosis. 53 62
8804016 1996
41
Detection of modified beta 2-microglobulin (beta 2m) from amyloid deposits in tenosynovial tissue of carpal tunnel syndrome (CTS) 53 62
7955417 1994
42
Amyloid and peripheral nervous system disease. 53 62
8187375 1994
43
Carpal tunnel syndrome: a major complication in hemodialysis patients. 53 62
7973484 1994
44
[Clinical and genetic heterogeneity in familial amyloidotic polyneuropathy associated with variant transthyretin]. 53 62
8411724 1993
45
[Computerized tomography and conventional radiography in the diagnosis of destructive spondyloarthropathy. Our experience with 30 patients undergoing periodic hemodialysis]. 53 62
1494670 1992
46
Familial amyloidotic polyneuropathy presenting with carpal tunnel syndrome and a new transthyretin mutation, asparagine 70. 53 62
1436517 1992
47
Cystic radiolucencies of carpal bones, distal radius and ulna as a marker for dialysis-associated amyloid osteoarthropathy. 53 62
1436294 1992
48
New mutant gene (transthyretin Arg 58) in cases with hereditary polyneuropathy detected by non-isotope method of single-strand conformation polymorphism analysis. 53 62
1656975 1991
49
[Rheumatologic complications and amyloidosis in dialysis patients]. 53 62
2183342 1990
50
Spatial Relationship of the Median Nerve and Transverse Carpal Ligament in Asymptomatic Hands. 62
36416297 2023

Variations for Carpal Tunnel Syndrome

ClinVar genetic disease variations for Carpal Tunnel Syndrome:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TTR NM_000371.4(TTR):c.424G>A (p.Val142Ile) SNV Pathogenic
13426 rs76992529 GRCh37: 18:29178618-29178618
GRCh38: 18:31598655-31598655
2 TTR NM_000371.4(TTR):c.148G>A (p.Val50Met) SNV Pathogenic
13417 rs28933979 GRCh37: 18:29172937-29172937
GRCh38: 18:31592974-31592974
3 TTR NM_000371.4(TTR):c.250T>C (p.Phe84Leu) SNV Pathogenic
13453 rs121918091 GRCh37: 18:29175132-29175132
GRCh38: 18:31595169-31595169
4 TTR NM_000371.4(TTR):c.400T>C (p.Tyr134His) SNV Pathogenic
13449 rs121918088 GRCh37: 18:29178594-29178594
GRCh38: 18:31598631-31598631
5 TTR NM_000371.4(TTR):c.122G>A (p.Arg41Gln) SNV Uncertain Significance
246463 rs879254269 GRCh37: 18:29172911-29172911
GRCh38: 18:31592948-31592948
6 TTR NM_000371.4(TTR):c.280G>C (p.Asp94His) SNV Uncertain Significance
181695 rs730881164 GRCh37: 18:29175162-29175162
GRCh38: 18:31595199-31595199

UniProtKB/Swiss-Prot genetic disease variations for Carpal Tunnel Syndrome:

73
# Symbol AA change Variation ID SNP ID
1 TTR p.Tyr134His VAR_007598 rs121918088

Expression for Carpal Tunnel Syndrome

Search GEO for disease gene expression data for Carpal Tunnel Syndrome.

Pathways for Carpal Tunnel Syndrome

Pathways related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 VEGFA TGFB1 IL6 IL1B ESR1 COL5A1
2
Show member pathways
13.76 VEGFA TTR TGFB1 PSMD9 IL6 IL1B
3 13.74 VEGFA TGFB1 TAC1 PSMD9 INS IL6
4
Show member pathways
13.26 VEGFA TGFB1 PSMD9 IL6 IL1B CCL2
5
Show member pathways
12.99 TGFB1 INS IL6 CCN2 CCL2 ACE
6
Show member pathways
12.68 TTR TGFB1 COMP COL5A1 ACAN
7 12.48 VEGFA TGFB1 INS IL6 IL1B CCN2
8
Show member pathways
12.13 TGFB1 COMP COL5A1 ACAN
9 12.09 IL1B IL6 TAC1 VEGFA
10 12.01 VEGFA TGFB1 INS IL6
11 11.86 TGFB1 INS IL6 IL1B
12
Show member pathways
11.81 TGFB1 IL6 IL1B
13 11.81 CCL2 IL6 TGFB1 VEGFA
14 11.8 VEGFA TGFB1 IL6 IL1B CCL2
15 11.79 TGFB1 INS IL6 ACAN
16 11.76 VEGFA TGFB1 IL1B COL5A1
17 11.71 TGFB1 IL6 IL1B
18
Show member pathways
11.69 VEGFA IL6 CCL2
19 11.67 TGFB1 IL6 IL1B
20
Show member pathways
11.62 IL1B IL6 VEGFA
21 11.62 TGFB1 IL6 ESR1 CCL2
22 11.56 ESR1 IL6 INS
23 11.54 VEGFA TGFB1 IL6
24 11.52 VEGFA TGFB1 CCN2
25 11.45 IL6 IL1B CCL2
26 11.44 INS IL6 CCL2
27 11.43 VEGFA TGFB1 IL6 IL1B CCL2
28 11.39 VEGFA TGFB1 INS IL6
29 11.23 IL6 IL1B CCL2
30 11.21 TGFB1 IL6 IL1B
31 11.17 SH3TC2 PMP22 MPZ
32 11.16 VEGFA TGFB1 IL6
33 11.16 TGFB1 IL6 IL1B GAP43 CCL2 ACAN
34 11.15 TGFB1 IL6 IL1B CCN2 CCL2
35 11 VEGFA IL6 IL1B CCL2
36 10.88 ACAN CCL2 CCN2 COL5A1 IL1B IL6
37 10.71 TGFB1 IL6 IL1B
38 10.67 CCL2 IL6

GO Terms for Carpal Tunnel Syndrome

Cellular components related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 ACAN ACE B2M CCL2 CCN2 COL5A1
2 extracellular matrix GO:0031012 9.93 VEGFA TGFB1 COMP COL5A1 CCN2 ACAN
3 extracellular space GO:0005615 9.74 VEGFA TTR TGFB1 TAC1 INS IL6

Biological processes related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TGFB1 IL1B CCL2
2 tendon development GO:0035989 9.73 COMP COL5A1
3 negative regulation of neurogenesis GO:0050768 9.73 B2M IL1B IL6
4 positive regulation of vascular endothelial growth factor production GO:0010575 9.72 TGFB1 IL6 IL1B
5 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.71 VEGFA ACE
6 response to laminar fluid shear stress GO:0034616 9.67 TGFB1 ACE
7 positive regulation of receptor signaling pathway via STAT GO:1904894 9.65 TGFB1 IL6
8 negative regulation of gap junction assembly GO:1903597 9.46 IL1B ACE
9 negative regulation of gene expression GO:0010629 9.4 VEGFA TGFB1 INS ESR1 CCN2 ACE
10 connective tissue development GO:0061448 9.37 TGFB1 CCN2
11 mononuclear cell proliferation GO:0032943 9.13 TGFB1 ACE

Molecular functions related to Carpal Tunnel Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 VEGFA TGFB1 IL6 IL1B CCL2

Sources for Carpal Tunnel Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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