MCID: CRR001
MIFTS: 42

Carrion's Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Carrion's Disease

MalaCards integrated aliases for Carrion's Disease:

Name: Carrion's Disease 12 3 15
Oroya Fever 12 60 3 74
Carrion Disease 12 60
Bartonellosis Due to Bartonella Bacilliformis Infection 60
Bartonella Infections 74

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050398
ICD10 34 A44.9
MESH via Orphanet 46 D001474
ICD10 via Orphanet 35 A44.0
UMLS via Orphanet 75 C0029307 C0348974
Orphanet 60 ORPHA64692

Summaries for Carrion's Disease

Disease Ontology : 12 A bartonellosis that results in infection located in endothelial cells or located in red blood cells, has material basis in Bartonella bacilliformis, which is transmitted by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards based summary : Carrion's Disease, also known as oroya fever, is related to bartonellosis and malaria. An important gene associated with Carrion's Disease is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions and Lung fibrosis. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and skin.

CDC : 3 Bartonella bacteria cause several diseases in humans. The most common is cat scratch disease.

Wikipedia : 77 Oroya fever or Carrion''s disease is an infectious disease produced by Bartonella bacilliformis... more...

Related Diseases for Carrion's Disease

Graphical network of the top 20 diseases related to Carrion's Disease:



Diseases related to Carrion's Disease

Symptoms & Phenotypes for Carrion's Disease

Drugs & Therapeutics for Carrion's Disease

Drugs for Carrion's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4,Phase 3 83905-01-5 447043 55185
3
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
4
Nevirapine Approved Phase 4 129618-40-2 4463
5
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
6
Tenofovir Approved, Experimental, Investigational Phase 4 147127-20-6 464205
7 Hormones Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 glucocorticoids Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
11 Hormone Antagonists Phase 4
12 Anti-Inflammatory Agents Phase 4
13
protease inhibitors Phase 4,Phase 3
14 Cytochrome P-450 Enzyme Inhibitors Phase 4
15 Antiviral Agents Phase 4,Phase 3
16 HIV Protease Inhibitors Phase 4,Phase 3
17 Atazanavir Sulfate Phase 4
18 Reverse Transcriptase Inhibitors Phase 4
19 Anti-HIV Agents Phase 4,Phase 3
20 Anti-Retroviral Agents Phase 4,Phase 3
21 Cytochrome P-450 CYP3A Inhibitors Phase 4
22 Anti-Infective Agents Phase 4,Phase 3
23 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
24 Cytochrome P-450 CYP3A Inducers Phase 4
25 Nucleic Acid Synthesis Inhibitors Phase 4
26
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
27
tannic acid Approved Phase 3 1401-55-4
28
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
29
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
30
Fosamprenavir Approved Phase 3 226700-79-4 131536
31
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
32 Analgesics, Non-Narcotic Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Interleukin-2 Phase 3
35 Analgesics Phase 3
36 Gentamicins Phase 3
37 Anti-Bacterial Agents Phase 3
38 Immunoglobulins
39 Antibodies
40 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
3 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
4 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
5 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
6 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
7 Bartonella in Liver Transplant Patients Recruiting NCT02595710

Search NIH Clinical Center for Carrion's Disease

Genetic Tests for Carrion's Disease

Anatomical Context for Carrion's Disease

MalaCards organs/tissues related to Carrion's Disease:

42
Endothelial, Liver, Skin, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Carrion's Disease:

20
Endothelial Cells Or

Publications for Carrion's Disease

Articles related to Carrion's Disease:

(show top 50) (show all 62)
# Title Authors Year
1
Carrion's disease: more than a neglected disease. ( 30909982 )
2019
2
Carrion's Disease: the Sound of Silence. ( 29187394 )
2018
3
Research trends in Carrion's disease in the last 60 years. A bibliometric assessment of Latin American scientific production. ( 29525795 )
2018
4
Molecular Detection of Bartonella bacilliformis in Lutzomyia maranonensis in Cajamarca, Peru: A New Potential Vector of Carrion's Disease in Peru? ( 30226144 )
2018
5
Oroya Fever, Verruga Peruana, and Other Bartonelloses Incidence Rates in Colombia (2009-2013). ( 30648063 )
2018
6
Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru. ( 28628613 )
2017
7
Carrion's disease: an eradicable illness? ( 27903286 )
2016
8
Carrion's disease after blood transfusion. ( 26674821 )
2016
9
Carrion's Disease: More Than a Sand Fly-Vectored Illness. ( 27736978 )
2016
10
Colonization of Lutzomyia verrucarum and Lutzomyia longipalpis Sand Flies (Diptera: Psychodidae) by Bartonella bacilliformis, the Etiologic Agent of Carrión's Disease. ( 26436553 )
2015
11
Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America? ( 26706684 )
2015
12
Oroya Fever and Daniel Carrion--A Fatal Quest. ( 26543959 )
2015
13
Diagnosis of Carrion's disease by direct blood PCR in thin blood smear negative samples. ( 24651298 )
2014
14
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion's Disease in Amazonas, Peru. ( 24847360 )
2014
15
Oroya fever and verruga peruana: bartonelloses unique to South America. ( 25032975 )
2014
16
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. ( 23409255 )
2013
17
Oroya fever and Daniel Carrion--a fatal quest. ( 24974512 )
2013
18
Carrion's disease (Bartonellosis bacilliformis) confirmed by histopathology in the High Forest of Peru. ( 15286824 )
2004
19
Population genetic analysis of Bartonella bacilliformis isolates from areas of peru where Carrion's disease is endemic and epidemic. ( 15297516 )
2004
20
Bartonelosis (Carrion's Disease) in the pediatric population of Peru: an overview and update. ( 15798808 )
2004
21
Carrión's disease: an altitude-associated infectious disease. ( 14656265 )
2003
22
Nationalism, Carrión's disease and medical geography in the Peruvian Andes. ( 15584200 )
2003
23
Bartonellosis (Carrión's disease) in the modern era. ( 11512081 )
2001
24
An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998. ( 10463692 )
1999
25
Tropical medicine and bacteriology in Boston and Peru: studies of Carrión's disease in the early twentieth century. ( 8757718 )
1996
26
Daniel Carrión and Carrión's disease. ( 1742572 )
1991
27
An epidemic of Oroya fever in the Peruvian Andes. ( 2316791 )
1990
28
Histology, immunohistochemistry, and ultrastructure of the verruga in Carrion's disease. ( 2428261 )
1986
29
A case of Carrion's disease associated with human sacrifice from the Huari culture of Southern Peru. ( 4606100 )
1974
30
Pathogenesis of the verruga of Carrion's disease. Ultrastructural studies. ( 5060580 )
1972
31
Daniel Carrión and Oroya fever. ( 4950363 )
1971
32
A history of bartonellosis (Carrión's disease). ( 4876803 )
1968
33
Treatment of the acute febrile phase of Carrión's disease with chloramphenicol. ( 14376776 )
1955
34
Carrión's disease. I. Studies on plants claimed to be reservoirs of Bartonella bacilliformis. ( 13065631 )
1953
35
Carrión's disease. II. Presence of Bartonella bacilliformis in the peripheral blood of patients with the benign form. ( 13065632 )
1953
36
Carrión's disease. III. Experimental infection of squirrels. ( 13065633 )
1953
37
Carrion's disease treated with chloromycetin. ( 24540616 )
1951
38
A study of 22 cases of Carrion's disease with intercurrent malaria. ( 15392068 )
1949
39
Clinical manifestations of Carrión's disease. ( 15393033 )
1949
40
Intercurrent infections of Carrion's disease observed in Peru. ( 18859832 )
1948
41
Bartonella bacilliformis anemia (Oroya fever); a study of 30 cases. ( 18875365 )
1948
42
The treatment of Carrion's disease with large transfusions. ( 20284814 )
1947
43
Penicillin therapy in human bartonellosis (Carrion's disease). ( 21007299 )
1945
44
The Bartonella and Related Parasites in Man and Animals (Oroya Fever and Verruga peruviana): (Section of Tropical Diseases and Parasitology). ( 19989875 )
1934
45
ETIOLOGY OF OROYA FEVER : XIV. THE INSECT VECTORS OF CARRION'S DISEASE. ( 19869598 )
1929
46
ETIOLOGY OF OROYA FEVER : XV. EFFECT OF IMMUNE SERUM ON THE COURSE OF BARTONELLA BACILLIFORMIS INFECTION IN MACACUS RHESUS. ( 19869628 )
1929
47
ETIOLOGY OF OROYA FEVER : XVI. VERRUGA IN THE DOG AND THE DONKEY. ( 19869639 )
1929
48
ETIOLOGY OF OROYA FEVER : X. COMPARATIVE STUDIES OF DIFFERENT STRAINS OF BARTONELLA BACILLIFORMIS, WITH SPECIAL REFERENCE TO THE RELATIONSHIP BETWEEN THE CLINICAL TYPES OF CARRION'S DISEASE AND THE VIRULENCE OF THE INFECTING ORGANISM. ( 19869408 )
1928
49
ETIOLOGY OF OROYA FEVER : XII. INFLUENCE OF MALARIAL INFECTION (PLASMODIUM INUI?), SPLENECTOMY, OR BOTH, UPON EXPERIMENTAL CARRION'S DISEASE IN MONKEYS. ( 19869445 )
1928
50
PHLEBOTOMUS AND OROYA FEVER AND VERRUGA PERUANA. ( 17806840 )
1928

Variations for Carrion's Disease

Expression for Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for Carrion's Disease

GO Terms for Carrion's Disease

Cellular components related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL11 CXCL10 CXCL9 EGF HMOX1 HSPD1

Biological processes related to Carrion's Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.83 CCL11 CXCL10 CXCL9 IL15
2 inflammatory response GO:0006954 9.71 CCL11 CXCL10 CXCL9 IL15
3 chemotaxis GO:0006935 9.63 CCL11 CXCL10 CXCL9
4 negative regulation of smooth muscle cell proliferation GO:0048662 9.54 HMOX1 IL15
5 response to ethanol GO:0045471 9.54 MT-CYB MT-ND4 OGG1
6 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.51 CXCL10 CXCL9
7 neutrophil chemotaxis GO:0030593 9.5 CCL11 CXCL10 CXCL9
8 ERK1 and ERK2 cascade GO:0070371 9.49 CCL11 EGF
9 response to light stimulus GO:0009416 9.48 DYNLRB1 OGG1
10 leukocyte chemotaxis GO:0030595 9.43 CXCL10 CXCL9
11 chemokine-mediated signaling pathway GO:0070098 9.43 CCL11 CXCL10 CXCL9
12 cellular response to heat GO:0034605 9.16 CXCL10 HMOX1
13 response to hypoxia GO:0001666 9.13 HMOX1 MT-CYB MT-ND4
14 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-ND4

Molecular functions related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CCL11 CXCL10 CXCL9 IL15
2 chemokine activity GO:0008009 9.13 CCL11 CXCL10 CXCL9
3 CXCR3 chemokine receptor binding GO:0048248 8.62 CXCL10 CXCL9
4 protein binding GO:0005515 10.1 ARF6 CCL11 CXCL10 CXCL9 DYNLRB1 EGF

Sources for Carrion's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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