MCID: CRR001
MIFTS: 36

Carrion's Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Carrion's Disease

MalaCards integrated aliases for Carrion's Disease:

Name: Carrion's Disease 12 15
Oroya Fever 12 59 72
Carrion Disease 12 59
Bartonellosis Due to Bartonella Bacilliformis Infection 59
Bartonella Infections 72

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050398
MESH via Orphanet 45 D001474
ICD10 via Orphanet 34 A44.0
UMLS via Orphanet 73 C0029307 C0348974
Orphanet 59 ORPHA64692
UMLS 72 C0004771 C0029307

Summaries for Carrion's Disease

Disease Ontology : 12 A bartonellosis that results in infection located in endothelial cells or located in red blood cells, has material basis in Bartonella bacilliformis, which is transmitted by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards based summary : Carrion's Disease, also known as oroya fever, is related to bartonellosis and malaria. An important gene associated with Carrion's Disease is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, skin and testes.

Related Diseases for Carrion's Disease

Diseases related to Carrion's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 bartonellosis 31.7 HSPE1 HSPD1 ASXL3
2 malaria 26.6 MT-CYB IL15 HMOX1 GYPB GYPA CXCL9
3 cat-scratch disease 11.4
4 sennetsu fever 10.7 HSPE1 HSPD1
5 chancroid 10.6 HSPE1 HSPD1
6 leukodystrophy, hypomyelinating, 4 10.5 HSPE1 HSPD1
7 sparganosis 10.5 MT-ND4 MT-CYB
8 vulvovaginitis 10.4 HSPD1 CCL11
9 acrodermatitis chronica atrophicans 10.3 CXCL10 CD40LG
10 leber optic atrophy 10.3 MT-ND4 MT-CYB
11 mitochondrial encephalomyopathy 10.3 MT-ND4 MT-CYB HSPD1
12 pneumocystosis 10.3 MT-CYB GYPA CD40LG
13 mitochondrial myopathy 10.2 MT-ND4 MT-CYB HSPD1
14 deficiency anemia 10.2
15 japanese spotted fever 10.2 CXCL10 CCL11
16 acute retrobulbar neuritis 10.2 MT-ND4 MT-CYB
17 ocular motor apraxia 10.2
18 rocky mountain spotted fever 10.2
19 spotted fever 10.2
20 orchitis 10.2
21 kala-azar 1 10.1
22 salmonellosis 10.1
23 bacterial infectious disease 10.1
24 glucosephosphate dehydrogenase deficiency 10.1
25 hemolytic anemia 10.1
26 leishmaniasis 10.1
27 cytokine deficiency 10.1
28 encephalopathy 10.1
29 acute chest syndrome 10.0 HMOX1 CD40LG
30 eosinophilic gastritis 10.0 IL15 CCL11
31 cryptosporidiosis 10.0 CXCL10 CD40LG CCL11
32 endotheliitis 9.9 CXCL9 CXCL10
33 sydenham chorea 9.9 CXCL9 CXCL10
34 anemia, autoimmune hemolytic 9.9 GYPA CD40LG
35 opsoclonus-myoclonus syndrome 9.8 CXCL9 CXCL10
36 viral infectious disease 9.8 IL15 CXCL10 CD40LG
37 pulmonary disease, chronic obstructive 9.7 HMOX1 CXCL10 CCL11
38 immunodeficiency with hyper-igm, type 2 9.6 CXCL9 CXCL10 CD40LG
39 night blindness, congenital stationary, type 1a 9.6 CXCL9 CXCL10 CCL11
40 mycobacterium tuberculosis 1 9.5 HSPE1 HSPD1 CXCL9 CXCL10
41 epidermolysis bullosa simplex, dowling-meara type 9.5 CXCL9 CXCL10
42 mycosis fungoides 9.4 IL15 CXCL9 CXCL10

Graphical network of the top 20 diseases related to Carrion's Disease:



Diseases related to Carrion's Disease

Symptoms & Phenotypes for Carrion's Disease

Drugs & Therapeutics for Carrion's Disease

Drugs for Carrion's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3 glucocorticoids Phase 4
4 Hormones Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Antineoplastic Agents, Hormonal Phase 4
7 Hormone Antagonists Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil

Search NIH Clinical Center for Carrion's Disease

Genetic Tests for Carrion's Disease

Anatomical Context for Carrion's Disease

MalaCards organs/tissues related to Carrion's Disease:

41
Endothelial, Skin, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Carrion's Disease:

19
Endothelial Cells, Red Blood Cells

Publications for Carrion's Disease

Articles related to Carrion's Disease:

(show top 50) (show all 141)
# Title Authors PMID Year
1
Bartonella spp. Bloodstream Infection in a Canadian Family. 38
30589638 2019
2
Carrion's disease: more than a neglected disease. 38
30909982 2019
3
Molecular Detection of Bartonella bacilliformis in Lutzomyia maranonensis in Cajamarca, Peru: A New Potential Vector of Carrion's Disease in Peru? 38
30226144 2018
4
Máxime "Max" Kuczyński: Father of Peruvian Public Health and of the 66th President of Peru. 38
30311725 2018
5
Oroya Fever, Verruga Peruana, and Other Bartonelloses Incidence Rates in Colombia (2009-2013). 38
30648063 2018
6
Seroprevalence and risk factors for infection with Bartonella bacilliformis in Loja province, Ecuador. 38
29941982 2018
7
Research trends in Carrion's disease in the last 60 years. A bibliometric assessment of Latin American scientific production. 38
29525795 2018
8
Carrion's Disease: the Sound of Silence. 38
29187394 2018
9
Utility of Molecular Identification and Quantitation of Bartonella Species with Species-Specific Real-Time PCR for Monitoring Treatment Response: A Case Series. 38
29997699 2018
10
Co-infection with Bartonella bacilliformis and Mycobacterium spp. in a coastal region of Peru. 38
29191209 2017
11
[Update on tegumentary leishmaniasis and carrion's disease vectors in Peru]. 38
29267774 2017
12
Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru. 38
28628613 2017
13
Detection of a Potential New Bartonella Species "Candidatus Bartonella rondoniensis" in Human Biting Kissing Bugs (Reduviidae; Triatominae). 38
28095503 2017
14
Carrion's disease: an eradicable illness? 38
27903286 2016
15
Carrion's disease after blood transfusion. 38
26674821 2016
16
Carrion's Disease: More Than a Sand Fly-Vectored Illness. 38
27736978 2016
17
Succinyl-CoA Synthetase: New Antigen Candidate of Bartonella bacilliformis. 38
27627803 2016
18
Whole-Genome Sequencing of Two Bartonella bacilliformis Strains. 38
27389274 2016
19
Evaluation of PCR Approaches for Detection of Bartonella bacilliformis in Blood Samples. 38
26959642 2016
20
Multi-Locus Sequence Typing of Bartonella bacilliformis DNA Performed Directly from Blood of Patients with Oroya's Fever During a Peruvian Outbreak. 38
26824740 2016
21
Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America? 38
26706684 2015
22
Complete Genome Sequence of Bartonella ancashensis Strain 20.00, Isolated from the Blood of a Patient with Verruga Peruana. 38
26543106 2015
23
Daniel Alcides Carrion (1857-1885) and a history of medical martyrdom. 38
24585618 2015
24
An unidentified cluster of infection in the Peruvian Amazon region. 38
25989173 2015
25
Oroya Fever and Daniel Carrion--A Fatal Quest. 38
26543959 2015
26
Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection. 38
26175727 2015
27
Possible vertical transmission of Bartonella bacilliformis in Peru. 38
25371184 2015
28
Proteins of Bartonella bacilliformis: Candidates for Vaccine Development. 38
26413097 2015
29
Oroya fever and verruga peruana: bartonelloses unique to South America. 38
25032975 2014
30
[Experiences in the prevention and control of Carrión's disease in Peru]. 38
25123877 2014
31
[Human bartonellosis: before and after Daniel Alcides Carrion]. 38
25123884 2014
32
Diagnosis of Carrion's disease by direct blood PCR in thin blood smear negative samples. 38
24651298 2014
33
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion's Disease in Amazonas, Peru. 38
24847360 2014
34
Oroya fever and Daniel Carrion--a fatal quest. 38
24974512 2013
35
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. 38
23409255 2013
36
[Do clinical trials contribute to research development in Peru? How can that be achieved?]. 38
23338640 2012
37
Daniel Carrion's experiment: the use of self-infection in the advance of medicine. 38
22441071 2012
38
Bartonella bacilliformis: a systematic review of the literature to guide the research agenda for elimination. 38
23145188 2012
39
The population structure of Lutzomyia verrucarum (Diptera: Psycodidae), a Bartonella bacilliformis and Leishmania peruviana vector in Peru. 38
22308774 2012
40
Bartonella spp.: throwing light on uncommon human infections. 38
20833105 2011
41
Bartonella infection: treatment and drug resistance. 38
21133691 2010
42
Skin diseases associated with Bartonella infection: facts and controversies. 38
20797506 2010
43
The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes. 38
20548954 2010
44
[Bartonella spp. as a zoonotic pathogens transmitting by blood-feeding arthropods]. 38
20450002 2010
45
Bartonellosis. 38
19362689 2009
46
Human bartonellosis: seroepidemiological and clinical features with an emphasis on data from Brazil - a review. 38
18592096 2008
47
[Cat scratch disease and other human infections caused by Bartonella species]. 38
18578430 2008
48
Isolation and characterization of Bartonella bacilliformis from an expatriate Ecuadorian. 38
18094131 2008
49
Immunological response in cases of complicated and uncomplicated bartonellosis during pregnancy. 38
18026643 2007
50
Molecular mechanisms of resistance to antibiotics in Bartonella bacilliformis. 38
17449882 2007

Variations for Carrion's Disease

Expression for Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for Carrion's Disease

GO Terms for Carrion's Disease

Cellular components related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 IL15 HSPD1 HMOX1 CXCL9 CXCL10 CD40LG

Biological processes related to Carrion's Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 IL15 CXCL9 CXCL10 CD40LG CCL11
2 chemotaxis GO:0006935 9.71 CXCL9 CXCL10 CCL11
3 cell-cell signaling GO:0007267 9.67 IL15 CXCL9 CXCL10 ADORA2A
4 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.63 CXCL9 CXCL10 ADORA2A
5 neutrophil chemotaxis GO:0030593 9.61 CXCL9 CXCL10 CCL11
6 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.55 CXCL9 CXCL10
7 positive regulation of interleukin-12 production GO:0032735 9.52 HSPD1 CD40LG
8 positive regulation of interleukin-10 production GO:0032733 9.51 HSPD1 CD40LG
9 chemokine-mediated signaling pathway GO:0070098 9.5 CXCL9 CXCL10 CCL11
10 leukocyte chemotaxis GO:0030595 9.49 CXCL9 CXCL10
11 negative regulation of neuron apoptotic process GO:0043524 9.48 HMOX1 ADORA2A
12 response to hypoxia GO:0001666 9.33 MT-ND4 MT-CYB HMOX1
13 cellular response to heat GO:0034605 9.26 HMOX1 CXCL10
14 inflammatory response GO:0006954 9.1 IL15 CXCL9 CXCL10 CD40LG CCL11 ADORA2A
15 electron transport coupled proton transport GO:0015990 8.96 MT-ND4 MT-CYB

Molecular functions related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.56 VSIR HSPD1 HMOX1 ADORA2A
2 chemokine activity GO:0008009 9.33 CXCL9 CXCL10 CCL11
3 cytokine activity GO:0005125 9.02 IL15 CXCL9 CXCL10 CD40LG CCL11
4 CXCR3 chemokine receptor binding GO:0048248 8.96 CXCL9 CXCL10

Sources for Carrion's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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