MCID: CRR001
MIFTS: 30

Carrion's Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Carrion's Disease

MalaCards integrated aliases for Carrion's Disease:

Name: Carrion's Disease 12 15
Oroya Fever 12 58 71
Carrion Disease 12 58
Bartonellosis Due to Bartonella Bacilliformis Infection 58
Bartonella Infections 71

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050398
MESH via Orphanet 44 D001474
ICD10 via Orphanet 33 A44.0
UMLS via Orphanet 72 C0029307 C0348974
Orphanet 58 ORPHA64692
UMLS 71 C0004771 C0029307

Summaries for Carrion's Disease

Disease Ontology : 12 A bartonellosis that results in infection located in endothelial cells or located in red blood cells, has material basis in Bartonella bacilliformis, which is transmitted by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards based summary : Carrion's Disease, also known as oroya fever, is related to cat-scratch disease and bartonellosis. An important gene associated with Carrion's Disease is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1). The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include endothelial cells, red blood cells and endothelial.

Related Diseases for Carrion's Disease

Graphical network of the top 20 diseases related to Carrion's Disease:



Diseases related to Carrion's Disease

Symptoms & Phenotypes for Carrion's Disease

Drugs & Therapeutics for Carrion's Disease

Drugs for Carrion's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3 Anti-Inflammatory Agents Phase 4
4 Hormone Antagonists Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 glucocorticoids Phase 4
7 Hormones Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil

Search NIH Clinical Center for Carrion's Disease

Genetic Tests for Carrion's Disease

Anatomical Context for Carrion's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Carrion's Disease:

19
Endothelial Cells, Red Blood Cells

MalaCards organs/tissues related to Carrion's Disease:

40
Endothelial, Skin, Testes

Publications for Carrion's Disease

Articles related to Carrion's Disease:

(show top 50) (show all 143)
# Title Authors PMID Year
1
Complete Genome Sequence of Bartonella bacilliformis Strain KC584 (ATCC 35686). 61
31896649 2020
2
[About Carrion street and bartonellosis]. 61
31859777 2019
3
Bartonella spp. Bloodstream Infection in a Canadian Family. 61
30589638 2019
4
Carrion's disease: more than a neglected disease. 61
30909982 2019
5
Molecular Detection of Bartonella bacilliformis in Lutzomyia maranonensis in Cajamarca, Peru: A New Potential Vector of Carrion's Disease in Peru? 61
30226144 2018
6
Máxime "Max" Kuczyński: Father of Peruvian Public Health and of the 66th President of Peru. 61
30311725 2018
7
Oroya Fever, Verruga Peruana, and Other Bartonelloses Incidence Rates in Colombia (2009-2013). 61
30648063 2018
8
Seroprevalence and risk factors for infection with Bartonella bacilliformis in Loja province, Ecuador. 61
29941982 2018
9
Research trends in Carrion's disease in the last 60 years. A bibliometric assessment of Latin American scientific production. 61
29525795 2018
10
Carrion's Disease: the Sound of Silence. 61
29187394 2018
11
Utility of Molecular Identification and Quantitation of Bartonella Species with Species-Specific Real-Time PCR for Monitoring Treatment Response: A Case Series. 61
29997699 2018
12
Co-infection with Bartonella bacilliformis and Mycobacterium spp. in a coastal region of Peru. 61
29191209 2017
13
[Update on tegumentary leishmaniasis and carrion's disease vectors in Peru]. 61
29267774 2017
14
Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru. 61
28628613 2017
15
Detection of a Potential New Bartonella Species "Candidatus Bartonella rondoniensis" in Human Biting Kissing Bugs (Reduviidae; Triatominae). 61
28095503 2017
16
Carrion's disease: an eradicable illness? 61
27903286 2016
17
Carrion's disease after blood transfusion. 61
26674821 2016
18
Carrion's Disease: More Than a Sand Fly-Vectored Illness. 61
27736978 2016
19
Succinyl-CoA Synthetase: New Antigen Candidate of Bartonella bacilliformis. 61
27627803 2016
20
Whole-Genome Sequencing of Two Bartonella bacilliformis Strains. 61
27389274 2016
21
Evaluation of PCR Approaches for Detection of Bartonella bacilliformis in Blood Samples. 61
26959642 2016
22
Multi-Locus Sequence Typing of Bartonella bacilliformis DNA Performed Directly from Blood of Patients with Oroya's Fever During a Peruvian Outbreak. 61
26824740 2016
23
Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America? 61
26706684 2015
24
Complete Genome Sequence of Bartonella ancashensis Strain 20.00, Isolated from the Blood of a Patient with Verruga Peruana. 61
26543106 2015
25
Daniel Alcides Carrion (1857-1885) and a history of medical martyrdom. 61
24585618 2015
26
An unidentified cluster of infection in the Peruvian Amazon region. 61
25989173 2015
27
Oroya Fever and Daniel Carrion--A Fatal Quest. 61
26543959 2015
28
Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection. 61
26175727 2015
29
Possible vertical transmission of Bartonella bacilliformis in Peru. 61
25371184 2015
30
Proteins of Bartonella bacilliformis: Candidates for Vaccine Development. 61
26413097 2015
31
Oroya fever and verruga peruana: bartonelloses unique to South America. 61
25032975 2014
32
[Experiences in the prevention and control of Carrión's disease in Peru]. 61
25123877 2014
33
[Human bartonellosis: before and after Daniel Alcides Carrion]. 61
25123884 2014
34
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion's Disease in Amazonas, Peru. 61
24847360 2014
35
Diagnosis of Carrion's disease by direct blood PCR in thin blood smear negative samples. 61
24651298 2014
36
Oroya fever and Daniel Carrion--a fatal quest. 61
24974512 2013
37
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. 61
23409255 2013
38
[Do clinical trials contribute to research development in Peru? How can that be achieved?]. 61
23338640 2012
39
Daniel Carrion's experiment: the use of self-infection in the advance of medicine. 61
22441071 2012
40
Bartonella bacilliformis: a systematic review of the literature to guide the research agenda for elimination. 61
23145188 2012
41
The population structure of Lutzomyia verrucarum (Diptera: Psycodidae), a Bartonella bacilliformis and Leishmania peruviana vector in Peru. 61
22308774 2012
42
Bartonella spp.: throwing light on uncommon human infections. 61
20833105 2011
43
Bartonella infection: treatment and drug resistance. 61
21133691 2010
44
Skin diseases associated with Bartonella infection: facts and controversies. 61
20797506 2010
45
The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes. 61
20548954 2010
46
[Bartonella spp. as a zoonotic pathogens transmitting by blood-feeding arthropods]. 61
20450002 2010
47
Bartonellosis. 61
19362689 2009
48
Human bartonellosis: seroepidemiological and clinical features with an emphasis on data from Brazil - a review. 61
18592096 2008
49
[Cat scratch disease and other human infections caused by Bartonella species]. 61
18578430 2008
50
Isolation and characterization of Bartonella bacilliformis from an expatriate Ecuadorian. 61
18094131 2008

Variations for Carrion's Disease

Expression for Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for Carrion's Disease

GO Terms for Carrion's Disease

Biological processes related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase activity GO:0006469 9.16 WARS1 UBASH3B
2 response to unfolded protein GO:0006986 8.96 HSPE1 HSPD1
3 protein folding GO:0006457 8.8 HSPE1 HSPD1 FKBP9

Sources for Carrion's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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