MCID: CRR001
MIFTS: 36

Carrion's Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Carrion's Disease

MalaCards integrated aliases for Carrion's Disease:

Name: Carrion's Disease 12 15
Oroya Fever 12 59 3 73
Carrion Disease 12 59
Bartonellosis Due to Bartonella Bacilliformis Infection 59
Bartonella Infections 73

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050398
Orphanet 59 ORPHA64692
MESH via Orphanet 45 D001474
UMLS via Orphanet 74 C0029307 C0348974
ICD10 via Orphanet 34 A44.0
ICD10 33 A44.9

Summaries for Carrion's Disease

Disease Ontology : 12 A bartonellosis that results in infection located in endothelial cells or located in red blood cells, has material basis in Bartonella bacilliformis, which is transmitted by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards based summary : Carrion's Disease, also known as oroya fever, is related to bartonellosis and cat-scratch disease. An important gene associated with Carrion's Disease is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions and Lung fibrosis. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include endothelial, skin and endothelial cells or.

CDC : 3 Bartonella bacteria cause several diseases in humans. The most common is cat scratch disease.

Wikipedia : 76 Oroya fever or Carrion''s disease is an infectious disease produced by Bartonella bacilliformis... more...

Related Diseases for Carrion's Disease

Graphical network of the top 20 diseases related to Carrion's Disease:



Diseases related to Carrion's Disease

Symptoms & Phenotypes for Carrion's Disease

Drugs & Therapeutics for Carrion's Disease

Drugs for Carrion's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
4
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
5
Nevirapine Approved Phase 4 129618-40-2 4463
6
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
7 Hormone Antagonists Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Antiviral Agents Phase 4,Phase 3
14 Nucleic Acid Synthesis Inhibitors Phase 4
15 HIV Protease Inhibitors Phase 4,Phase 3
16 Anti-HIV Agents Phase 4,Phase 3
17 Cytochrome P-450 CYP3A Inducers Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4
19 Anti-Infective Agents Phase 4,Phase 3
20 Atazanavir Sulfate Phase 4
21 Reverse Transcriptase Inhibitors Phase 4
22 Anti-Retroviral Agents Phase 4,Phase 3
23 Cytochrome P-450 CYP3A Inhibitors Phase 4
24
protease inhibitors Phase 4,Phase 3
25 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
26
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
27 tannic acid Approved Phase 3
28
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
29
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
30
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
31
Fosamprenavir Approved Phase 3 226700-79-4 131536
32 Peripheral Nervous System Agents Phase 3
33 Analgesics Phase 3
34 Interleukin-2 Phase 3
35 Analgesics, Non-Narcotic Phase 3
36 Gentamicins Phase 3
37 Anti-Bacterial Agents Phase 3
38 Immunoglobulins
39 Antibodies
40 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
3 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
4 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
5 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
6 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
7 Bartonella in Liver Transplant Patients Recruiting NCT02595710

Search NIH Clinical Center for Carrion's Disease

Genetic Tests for Carrion's Disease

Anatomical Context for Carrion's Disease

MalaCards organs/tissues related to Carrion's Disease:

41
Endothelial, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Carrion's Disease:

19
Endothelial Cells Or

Publications for Carrion's Disease

Articles related to Carrion's Disease:

(show all 48)
# Title Authors Year
1
Carrion's Disease: the Sound of Silence. ( 29187394 )
2018
2
Research trends in Carrion's disease in the last 60 years. A bibliometric assessment of Latin American scientific production. ( 29525795 )
2018
3
Molecular Detection of Bartonella bacilliformis in Lutzomyia maranonensis in Cajamarca, Peru: A New Potential Vector of Carrion's Disease in Peru? ( 30226144 )
2018
4
Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru. ( 28628613 )
2017
5
Carrion's disease: an eradicable illness? ( 27903286 )
2016
6
Carrion's Disease: More Than a Sand Fly-Vectored Illness. ( 27736978 )
2016
7
Carrion's disease after blood transfusion. ( 26674821 )
2015
8
Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America? ( 26706684 )
2015
9
Oroya Fever and Daniel Carrion--A Fatal Quest. ( 26543959 )
2015
10
Diagnosis of Carrion's disease by direct blood PCR in thin blood smear negative samples. ( 24651298 )
2014
11
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion's Disease in Amazonas, Peru. ( 24847360 )
2014
12
Oroya fever and verruga peruana: bartonelloses unique to South America. ( 25032975 )
2014
13
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. ( 23409255 )
2013
14
Oroya fever and Daniel Carrion--a fatal quest. ( 24974512 )
2013
15
Carrion's disease (Bartonellosis bacilliformis) confirmed by histopathology in the High Forest of Peru. ( 15286824 )
2004
16
Population genetic analysis of Bartonella bacilliformis isolates from areas of peru where Carrion's disease is endemic and epidemic. ( 15297516 )
2004
17
Bartonelosis (Carrion's Disease) in the pediatric population of Peru: an overview and update. ( 15798808 )
2004
18
An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998. ( 10463692 )
1999
19
An epidemic of Oroya fever in the Peruvian Andes. ( 2316791 )
1990
20
Histology, immunohistochemistry, and ultrastructure of the verruga in Carrion's disease. ( 2428261 )
1986
21
A case of Carrion's disease associated with human sacrifice from the Huari culture of Southern Peru. ( 4606100 )
1974
22
Pathogenesis of the verruga of Carrion's disease. Ultrastructural studies. ( 5060580 )
1972
23
Daniel Carrión and Oroya fever. ( 4950363 )
1971
24
Carrion's disease treated with chloromycetin. ( 24540616 )
1951
25
A study of 22 cases of Carrion's disease with intercurrent malaria. ( 15392068 )
1949
26
Intercurrent infections of Carrion's disease observed in Peru. ( 18859832 )
1948
27
Bartonella bacilliformis anemia (Oroya fever); a study of 30 cases. ( 18875365 )
1948
28
The treatment of Carrion's disease with large transfusions. ( 20284814 )
1947
29
Penicillin therapy in human bartonellosis (Carrion's disease). ( 21007299 )
1945
30
The Bartonella and Related Parasites in Man and Animals (Oroya Fever and Verruga peruviana): (Section of Tropical Diseases and Parasitology). ( 19989875 )
1934
31
ETIOLOGY OF OROYA FEVER : XIV. THE INSECT VECTORS OF CARRION'S DISEASE. ( 19869598 )
1929
32
ETIOLOGY OF OROYA FEVER : XV. EFFECT OF IMMUNE SERUM ON THE COURSE OF BARTONELLA BACILLIFORMIS INFECTION IN MACACUS RHESUS. ( 19869628 )
1929
33
ETIOLOGY OF OROYA FEVER : XVI. VERRUGA IN THE DOG AND THE DONKEY. ( 19869639 )
1929
34
ETIOLOGY OF OROYA FEVER : X. COMPARATIVE STUDIES OF DIFFERENT STRAINS OF BARTONELLA BACILLIFORMIS, WITH SPECIAL REFERENCE TO THE RELATIONSHIP BETWEEN THE CLINICAL TYPES OF CARRION'S DISEASE AND THE VIRULENCE OF THE INFECTING ORGANISM. ( 19869408 )
1928
35
ETIOLOGY OF OROYA FEVER : XII. INFLUENCE OF MALARIAL INFECTION (PLASMODIUM INUI?), SPLENECTOMY, OR BOTH, UPON EXPERIMENTAL CARRION'S DISEASE IN MONKEYS. ( 19869445 )
1928
36
PHLEBOTOMUS AND OROYA FEVER AND VERRUGA PERUANA. ( 17806840 )
1928
37
ETIOLOGY OF OROYA FEVER : IX. BACTERIUM PERUVIANUM, N. SP., A SECONDARY INVADER OF THE LESIONS OF VERRUGA PERUANA. ( 19869395 )
1928
38
ETIOLOGY OF OROYA FEVER : XI. COMPARISON OF BARTONELLA BACILLIFORMIS AND BARTONELLA MURIS. CULTIVATION OF BACTERIUM MURIUM, N. SP. ( 19869409 )
1928
39
ETIOLOGY OF OROYA FEVER : XIII. CHEMOTHERAPY IN EXPERIMENTAL BARTONELLA BACILLIFORMIS INFECTION. ( 19869508 )
1928
40
ETIOLOGY OF OROYA FEVER : VI. PATHOLOGICAL CHANGES OBSERVED IN ANIMALS EXPERIMENTALLY INFECTED WITH BARTONELLA BACILLIFORMIS. THE DISTRIBUTION OF THE PARASITES IN THE TISSUES. ( 19869264 )
1927
41
ETIOLOGY OF OROYA FEVER : VII. THE RESPONSE OF THE SKIN OF MACACUS RHESUS AND ANTHROPOID APES TO INOCULATION WITH BARTONELLA BACILLIFORMIS. ( 19869265 )
1927
42
ETIOLOGY OF OROYA FEVER : VIII. EXPERIMENTS ON CROSS-IMMUNITY BETWEEN OROYA FEVER AND VERRUGA PERUANA. ( 19869288 )
1927
43
A PRELIMINARY REPORT ON THE CULTIVATION OF THE MICROBE OF OROYA FEVER. ( 17741819 )
1926
44
ETIOLOGY OF OROYA FEVER : I. CULTIVATION OF BARTONELLA BACILLIFORMIS. ( 19869166 )
1926
45
ETIOLOGY OF OROYA FEVER : II. VIABILITY OF BARTONELLA BACILLIFORMIS IN CULTURES AND IN THE PRESERVED BLOOD AND AN EXCISED NODULE OF MACACUS RHESUS. ( 19869204 )
1926
46
ETIOLOGY OF OROYA FEVER : III. THE BEHAVIOR OF BARTONELLA BACILLIFORMIS IN MACACUS RHESUS. ( 19869217 )
1926
47
ETIOLOGY OF OROYA FEVER : IV. THE EFFECT OF INOCULATION OF ANTHROPOID APES WITH BARTONELLA BACILLIFORMIS. ( 19869218 )
1926
48
ETIOLOGY OF OROYA FEVER : V. THE EXPERIMENTAL TRANSMISSION OF BARTONELLA BACILLIFORMIS BY TICKS (DERMACENTOR ANDERSONI). ( 19869219 )
1926

Variations for Carrion's Disease

Expression for Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for Carrion's Disease

GO Terms for Carrion's Disease

Cellular components related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL11 CXCL10 CXCL9 EGF HMOX1 HSPD1

Biological processes related to Carrion's Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.84 CCL11 CXCL10 CXCL9 IL15
2 inflammatory response GO:0006954 9.73 CCL11 CXCL10 CXCL9 IL15
3 chemotaxis GO:0006935 9.65 CCL11 CXCL10 CXCL9
4 negative regulation of smooth muscle cell proliferation GO:0048662 9.55 HMOX1 IL15
5 response to ethanol GO:0045471 9.54 MT-CYB MT-ND4 OGG1
6 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.52 CXCL10 CXCL9
7 ERK1 and ERK2 cascade GO:0070371 9.51 CCL11 EGF
8 neutrophil chemotaxis GO:0030593 9.5 CCL11 CXCL10 CXCL9
9 response to light stimulus GO:0009416 9.49 DYNLRB1 OGG1
10 leukocyte chemotaxis GO:0030595 9.46 CXCL10 CXCL9
11 chemokine-mediated signaling pathway GO:0070098 9.43 CCL11 CXCL10 CXCL9
12 positive regulation of cAMP-mediated signaling GO:0043950 9.4 CXCL10 CXCL9
13 cellular response to heat GO:0034605 9.33 CXCL10 HMOX1 HSPD1
14 response to hypoxia GO:0001666 9.26 HMOX1 HSPD1 MT-CYB MT-ND4
15 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-ND4

Molecular functions related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CCL11 CXCL10 CXCL9 IL15
2 chemokine activity GO:0008009 9.13 CCL11 CXCL10 CXCL9
3 CXCR3 chemokine receptor binding GO:0048248 8.62 CXCL10 CXCL9
4 protein binding GO:0005515 10.1 ARF6 CCL11 CXCL10 CXCL9 DYNLRB1 EGF

Sources for Carrion's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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