MCID: CRR001
MIFTS: 40

Carrion's Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Carrion's Disease

MalaCards integrated aliases for Carrion's Disease:

Name: Carrion's Disease 12 15
Oroya Fever 12 59 3 73
Carrion Disease 12 59
Bartonellosis Due to Bartonella Bacilliformis Infection 59
Bartonella Infections 73

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050398
Orphanet 59 ORPHA64692
MESH via Orphanet 45 D001474
UMLS via Orphanet 74 C0029307 C0348974
ICD10 via Orphanet 34 A44.0
ICD10 33 A44.9
UMLS 73 C0029307

Summaries for Carrion's Disease

Disease Ontology : 12 A bartonellosis that results in infection located in endothelial cells or located in red blood cells, has material basis in Bartonella bacilliformis, which is transmitted by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards based summary : Carrion's Disease, also known as oroya fever, is related to cat-scratch disease and sennetsu fever. An important gene associated with Carrion's Disease is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include endothelial cells or, endothelial and liver.

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Wikipedia : 76 Oroya fever or Carrion\'s disease is an infectious disease produced by Bartonella bacilliformis... more...

Related Diseases for Carrion's Disease

Graphical network of the top 20 diseases related to Carrion's Disease:



Diseases related to Carrion's Disease

Symptoms & Phenotypes for Carrion's Disease

Drugs & Therapeutics for Carrion's Disease

Drugs for Carrion's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
4
Nevirapine Approved Phase 4 129618-40-2 4463
5
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Anti-HIV Agents Phase 4,Phase 3
13 Anti-Infective Agents Phase 4,Phase 3
14 Anti-Retroviral Agents Phase 4,Phase 3
15 Antiviral Agents Phase 4,Phase 3
16 Atazanavir Sulfate Phase 4
17 Cytochrome P-450 CYP3A Inducers Phase 4
18 Cytochrome P-450 CYP3A Inhibitors Phase 4
19 Cytochrome P-450 Enzyme Inhibitors Phase 4
20 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
21 HIV Protease Inhibitors Phase 4,Phase 3
22 Nucleic Acid Synthesis Inhibitors Phase 4
23
protease inhibitors Phase 4,Phase 3
24 Reverse Transcriptase Inhibitors Phase 4
25
Tenofovir Phase 4 147127-20-6 464205
26
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
27
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
28
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
29
Fosamprenavir Approved Phase 3 226700-79-4 131536
30
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
31 tannic acid Approved, Nutraceutical Phase 3
32 Analgesics Phase 3
33 Analgesics, Non-Narcotic Phase 3
34 Interleukin-2 Phase 3
35 Peripheral Nervous System Agents Phase 3
36 Anti-Bacterial Agents Phase 3
37 Gentamicins Phase 3
38 Antibodies
39 Immunoglobulins
40 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
3 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
4 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
5 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
6 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
7 Bartonella in Liver Transplant Patients Recruiting NCT02595710

Search NIH Clinical Center for Carrion's Disease

Genetic Tests for Carrion's Disease

Anatomical Context for Carrion's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Carrion's Disease:

19
Endothelial Cells Or

MalaCards organs/tissues related to Carrion's Disease:

41
Endothelial, Liver

Publications for Carrion's Disease

Articles related to Carrion's Disease:

(show all 23)
# Title Authors Year
1
Carrion's Disease: the Sound of Silence. ( 29187394 )
2018
2
Research trends in Carrion's disease in the last 60 years. A bibliometric assessment of Latin American scientific production. ( 29525795 )
2018
3
Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru. ( 28628613 )
2017
4
Carrion's disease: an eradicable illness? ( 27903286 )
2016
5
Carrion's Disease: More Than a Sand Fly-Vectored Illness. ( 27736978 )
2016
6
Carrion's disease after blood transfusion. ( 26674821 )
2015
7
Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America? ( 26706684 )
2015
8
Diagnosis of Carrion's disease by direct blood PCR in thin blood smear negative samples. ( 24651298 )
2014
9
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion's Disease in Amazonas, Peru. ( 24847360 )
2014
10
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. ( 23409255 )
2013
11
Carrion's disease (Bartonellosis bacilliformis) confirmed by histopathology in the High Forest of Peru. ( 15286824 )
2004
12
Population genetic analysis of Bartonella bacilliformis isolates from areas of peru where Carrion's disease is endemic and epidemic. ( 15297516 )
2004
13
Bartonelosis (Carrion's Disease) in the pediatric population of Peru: an overview and update. ( 15798808 )
2004
14
Histology, immunohistochemistry, and ultrastructure of the verruga in Carrion's disease. ( 2428261 )
1986
15
A case of Carrion's disease associated with human sacrifice from the Huari culture of Southern Peru. ( 4606100 )
1974
16
Pathogenesis of the verruga of Carrion's disease. Ultrastructural studies. ( 5060580 )
1972
17
Carrion's disease treated with chloromycetin. ( 24540616 )
1951
18
A study of 22 cases of Carrion's disease with intercurrent malaria. ( 15392068 )
1949
19
Intercurrent infections of Carrion's disease observed in Peru. ( 18859832 )
1948
20
The treatment of Carrion's disease with large transfusions. ( 20284814 )
1947
21
Penicillin therapy in human bartonellosis (Carrion's disease). ( 21007299 )
1945
22
ETIOLOGY OF OROYA FEVER : XIV. THE INSECT VECTORS OF CARRION'S DISEASE. ( 19869598 )
1929
23
ETIOLOGY OF OROYA FEVER : X. COMPARATIVE STUDIES OF DIFFERENT STRAINS OF BARTONELLA BACILLIFORMIS, WITH SPECIAL REFERENCE TO THE RELATIONSHIP BETWEEN THE CLINICAL TYPES OF CARRION'S DISEASE AND THE VIRULENCE OF THE INFECTING ORGANISM. ( 19869408 )
1928

Variations for Carrion's Disease

Expression for Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for Carrion's Disease

GO Terms for Carrion's Disease

Cellular components related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 CCL11 CD40LG CXCL10 CXCL9 EGF HMOX1

Biological processes related to Carrion's Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 CCL11 CD40LG CXCL10 CXCL9 IL15
2 response to ethanol GO:0045471 9.63 MT-CYB MT-ND4 OGG1
3 regulation of signaling receptor activity GO:0010469 9.55 CCL11 CD40LG CXCL10 CXCL9 IL15
4 positive regulation of leukocyte chemotaxis GO:0002690 9.49 CXCL10 CXCL9
5 positive regulation of interleukin-10 production GO:0032733 9.48 CD40LG HSPD1
6 positive regulation of cAMP-mediated signaling GO:0043950 9.43 CXCL10 CXCL9
7 chemokine-mediated signaling pathway GO:0070098 9.43 CCL11 CXCL10 CXCL9
8 positive regulation of cAMP metabolic process GO:0030816 9.4 CXCL10 CXCL9
9 T cell chemotaxis GO:0010818 9.37 CXCL10 CXCL9
10 inflammatory response GO:0006954 9.35 CCL11 CD40LG CXCL10 CXCL9 IL15
11 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-ND4

Molecular functions related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL11 CXCL10 CXCL9
2 CXCR chemokine receptor binding GO:0045236 9.26 CXCL10 CXCL9
3 cytokine activity GO:0005125 9.02 CCL11 CD40LG CXCL10 CXCL9 IL15
4 CXCR3 chemokine receptor binding GO:0048248 8.96 CXCL10 CXCL9

Sources for Carrion's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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