MCID: CRR001
MIFTS: 30

Carrion's Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Carrion's Disease

MalaCards integrated aliases for Carrion's Disease:

Name: Carrion's Disease 12 15
Oroya Fever 12 58 71
Carrion Disease 12 58
Bartonellosis Due to Bartonella Bacilliformis Infection 58
Bartonella Infections 71

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050398
MESH via Orphanet 44 D001474
ICD10 via Orphanet 33 A44.0
UMLS via Orphanet 72 C0029307 C0348974
Orphanet 58 ORPHA64692
UMLS 71 C0004771 C0029307

Summaries for Carrion's Disease

Disease Ontology : 12 A bartonellosis that results in infection located in endothelial cells or located in red blood cells, has material basis in Bartonella bacilliformis, which is transmitted by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards based summary : Carrion's Disease, also known as oroya fever, is related to cat-scratch disease and bartonellosis. An important gene associated with Carrion's Disease is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1). The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include endothelial cells, red blood cells and endothelial.

Related Diseases for Carrion's Disease

Graphical network of the top 20 diseases related to Carrion's Disease:



Diseases related to Carrion's Disease

Symptoms & Phenotypes for Carrion's Disease

Drugs & Therapeutics for Carrion's Disease

Drugs for Carrion's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043 55185
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4
4 glucocorticoids Phase 4
5 Hormone Antagonists Phase 4
6 Antineoplastic Agents, Hormonal Phase 4
7 Hormones Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil

Search NIH Clinical Center for Carrion's Disease

Genetic Tests for Carrion's Disease

Anatomical Context for Carrion's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Carrion's Disease:

19
Endothelial Cells, Red Blood Cells

MalaCards organs/tissues related to Carrion's Disease:

40
Endothelial, Skin, Testes

Publications for Carrion's Disease

Articles related to Carrion's Disease:

(show top 50) (show all 141)
# Title Authors PMID Year
1
Bartonella spp. Bloodstream Infection in a Canadian Family. 61
30589638 2019
2
Carrion's disease: more than a neglected disease. 61
30909982 2019
3
Molecular Detection of Bartonella bacilliformis in Lutzomyia maranonensis in Cajamarca, Peru: A New Potential Vector of Carrion's Disease in Peru? 61
30226144 2018
4
Máxime "Max" Kuczyński: Father of Peruvian Public Health and of the 66th President of Peru. 61
30311725 2018
5
Oroya Fever, Verruga Peruana, and Other Bartonelloses Incidence Rates in Colombia (2009-2013). 61
30648063 2018
6
Seroprevalence and risk factors for infection with Bartonella bacilliformis in Loja province, Ecuador. 61
29941982 2018
7
Research trends in Carrion's disease in the last 60 years. A bibliometric assessment of Latin American scientific production. 61
29525795 2018
8
Carrion's Disease: the Sound of Silence. 61
29187394 2018
9
Utility of Molecular Identification and Quantitation of Bartonella Species with Species-Specific Real-Time PCR for Monitoring Treatment Response: A Case Series. 61
29997699 2018
10
Co-infection with Bartonella bacilliformis and Mycobacterium spp. in a coastal region of Peru. 61
29191209 2017
11
[Update on tegumentary leishmaniasis and carrion's disease vectors in Peru]. 61
29267774 2017
12
Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru. 61
28628613 2017
13
Detection of a Potential New Bartonella Species "Candidatus Bartonella rondoniensis" in Human Biting Kissing Bugs (Reduviidae; Triatominae). 61
28095503 2017
14
Carrion's disease: an eradicable illness? 61
27903286 2016
15
Carrion's disease after blood transfusion. 61
26674821 2016
16
Carrion's Disease: More Than a Sand Fly-Vectored Illness. 61
27736978 2016
17
Succinyl-CoA Synthetase: New Antigen Candidate of Bartonella bacilliformis. 61
27627803 2016
18
Whole-Genome Sequencing of Two Bartonella bacilliformis Strains. 61
27389274 2016
19
Evaluation of PCR Approaches for Detection of Bartonella bacilliformis in Blood Samples. 61
26959642 2016
20
Multi-Locus Sequence Typing of Bartonella bacilliformis DNA Performed Directly from Blood of Patients with Oroya's Fever During a Peruvian Outbreak. 61
26824740 2016
21
Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America? 61
26706684 2015
22
Complete Genome Sequence of Bartonella ancashensis Strain 20.00, Isolated from the Blood of a Patient with Verruga Peruana. 61
26543106 2015
23
Daniel Alcides Carrion (1857-1885) and a history of medical martyrdom. 61
24585618 2015
24
An unidentified cluster of infection in the Peruvian Amazon region. 61
25989173 2015
25
Oroya Fever and Daniel Carrion--A Fatal Quest. 61
26543959 2015
26
Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection. 61
26175727 2015
27
Possible vertical transmission of Bartonella bacilliformis in Peru. 61
25371184 2015
28
Proteins of Bartonella bacilliformis: Candidates for Vaccine Development. 61
26413097 2015
29
Oroya fever and verruga peruana: bartonelloses unique to South America. 61
25032975 2014
30
[Human bartonellosis: before and after Daniel Alcides Carrion]. 61
25123884 2014
31
[Experiences in the prevention and control of Carrión's disease in Peru]. 61
25123877 2014
32
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion's Disease in Amazonas, Peru. 61
24847360 2014
33
Diagnosis of Carrion's disease by direct blood PCR in thin blood smear negative samples. 61
24651298 2014
34
Oroya fever and Daniel Carrion--a fatal quest. 61
24974512 2013
35
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. 61
23409255 2013
36
[Do clinical trials contribute to research development in Peru? How can that be achieved?]. 61
23338640 2012
37
Daniel Carrion's experiment: the use of self-infection in the advance of medicine. 61
22441071 2012
38
Bartonella bacilliformis: a systematic review of the literature to guide the research agenda for elimination. 61
23145188 2012
39
The population structure of Lutzomyia verrucarum (Diptera: Psycodidae), a Bartonella bacilliformis and Leishmania peruviana vector in Peru. 61
22308774 2012
40
Bartonella spp.: throwing light on uncommon human infections. 61
20833105 2011
41
Bartonella infection: treatment and drug resistance. 61
21133691 2010
42
Skin diseases associated with Bartonella infection: facts and controversies. 61
20797506 2010
43
The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes. 61
20548954 2010
44
[Bartonella spp. as a zoonotic pathogens transmitting by blood-feeding arthropods]. 61
20450002 2010
45
Bartonellosis. 61
19362689 2009
46
Human bartonellosis: seroepidemiological and clinical features with an emphasis on data from Brazil - a review. 61
18592096 2008
47
[Cat scratch disease and other human infections caused by Bartonella species]. 61
18578430 2008
48
Isolation and characterization of Bartonella bacilliformis from an expatriate Ecuadorian. 61
18094131 2008
49
Immunological response in cases of complicated and uncomplicated bartonellosis during pregnancy. 61
18026643 2007
50
Molecular mechanisms of resistance to antibiotics in Bartonella bacilliformis. 61
17449882 2007

Variations for Carrion's Disease

Expression for Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for Carrion's Disease

GO Terms for Carrion's Disease

Biological processes related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase activity GO:0006469 9.16 WARS1 UBASH3B
2 response to unfolded protein GO:0006986 8.96 HSPE1 HSPD1
3 protein folding GO:0006457 8.8 HSPE1 HSPD1 FKBP9

Sources for Carrion's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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