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MCID: CRT017
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Cartilage Disease

Categories: Bone diseases, Muscle diseases
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Aliases & Classifications for Cartilage Disease

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MalaCards integrated aliases for Cartilage Disease:

Name: Cartilage Disease 11 14 36 16
Cartilage Diseases 53 43 71
Cartilage 16 75
Cartilage Disorders 41
Cartilage Disorder 11
Chondropathy 11

Classifications:

MalaCards categories:
Anatomical: Bone diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:1222
MeSH 43 D002357
SNOMED-CT 68 50927007
UMLS 71 C0007302
Sources

Summaries for Cartilage Disease

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MedlinePlus: 41 Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. It also gives shape and support to other parts of your body, such as your ears, nose and windpipe. Healthy cartilage helps you move by allowing your bones to glide over each other. It also protects bones by preventing them from rubbing against each other. Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. It can also lead to joint damage and deformity. Causes of cartilage problems include : Tears and injuries, such as sports injuries Genetic factors Other disorders, such as some types of arthritis Osteoarthritis results from breakdown of cartilage. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary: Cartilage Disease, also known as cartilage diseases, is related to multiple epiphyseal dysplasia and achondroplasia, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Cartilage Disease is COL10A1 (Collagen Type X Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Collagen chain trimerization. The drugs Acetaminophen and Glucosamine have been mentioned in the context of this disorder. Affiliated tissues include cartilage, bone marrow and bone, and related phenotypes are limbs/digits/tail and growth/size/body region

Disease Ontology: 11 A connective tissue disease that is located in cartilage.

Wikipedia: 75 Cartilage is a resilient and smooth type of connective tissue. In tetrapods, it covers and protects the... more...
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Related Diseases for Cartilage Disease

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Diseases related to Cartilage Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1573)
# Related Disease Score Top Affiliating Genes
1 multiple epiphyseal dysplasia 32.3 COMP COL2A1 COL10A1 ACAN
2 achondroplasia 32.2 SOX9 COMP COL2A1 ACAN
3 achondrogenesis 32.0 COMP COL2A1 COL10A1 ACAN
4 kniest dysplasia 32.0 COMP COL2A1 COL10A1
5 enchondromatosis, multiple, ollier type 32.0 SOX9 RUNX2 MMP13 IHH COL2A1 ACAN
6 platyspondylic lethal skeletal dysplasia, torrance type 31.9 COMP COL2A1 COL10A1
7 chondrocalcinosis 31.9 MMP3 IL1B CRP
8 kashin-beck disease 31.9 TNF IL1B COL2A1
9 achondrogenesis, type ii 31.7 COMP COL2A1 COL10A1 ACAN
10 hypochondroplasia 31.7 SOX9 IHH COL2A1 COL10A1 ACAN
11 metatropic dysplasia 31.6 SOX9 RUNX2 COL2A1 ACAN
12 fibrochondrogenesis 31.6 SOX9 GDF5 COL2A1 ACAN
13 spondyloepiphyseal dysplasia with congenital joint dislocations 31.6 IHH COMP COL2A1 ACAN
14 campomelic dysplasia 31.5 SOX9 RUNX2 IHH COL2A1 COL10A1 ACAN
15 acromesomelic dysplasia 31.4 IHH GDF5 COL2A1 COL10A1 ACAN
16 pseudoachondroplasia 31.3 COMP COL2A1 ACAN
17 chondromalacia 31.3 UBA1 TNF IL1B CRP COMP COL2A1
18 spondyloarthropathy 1 31.0 TNF MMP3 IL1B CRP
19 proteasome-associated autoinflammatory syndrome 1 31.0 TNF IL1B CRP
20 ankylosis 31.0 TNF RUNX2 CRP
21 spondylitis 30.9 TNF IL1B CRP
22 rheumatoid arthritis 30.9 TNF PRG4 MMP3 MMP13 IL1B CRP
23 bone development disease 30.8 SOX9 RUNX2 MIR140 IHH GDF5 COMP
24 juvenile rheumatoid arthritis 30.8 TNF IL1B CRP
25 osteomyelitis 30.8 TNF IL1B CRP
26 reactive arthritis 30.7 TNF CRP COMP
27 metaphyseal dysplasia 30.7 RUNX2 MMP13 COL2A1 COL10A1
28 arthritis 30.7 TNF MMP3 MMP13 IL1B CRP COMP
29 cleft palate, isolated 30.6 SOX9 RUNX2 MIR140 IHH COL2A1
30 thanatophoric dysplasia, type i 30.6 IHH COMP COL2A1
31 bronchiectasis 30.6 TNF IL1B CRP
32 septic arthritis 30.6 TNF MMP3 MMP13 IL1B CRP ACAN
33 psoriatic arthritis 30.6 TNF MMP3 IL1B CRP COMP
34 spondyloepiphyseal dysplasia congenita 30.5 COMP COL2A1 COL10A1
35 common cold 30.4 TNF IL1B CRP
36 middle ear disease 30.4 TNF IL1B CRP
37 erysipelas 30.4 TNF IL1B CRP
38 back pain 30.4 MMP3 IL1B CRP
39 basal cell carcinoma 30.3 TNF MMP3 MMP13 MIR140 IHH
40 scoliosis 30.3 SOX9 RUNX2 MMP3 MMP13 COMP COL2A1
41 aspiration pneumonia 30.3 TNF IL1B CRP
42 hypochondrogenesis 30.3 COMP COL2A1 COL10A1 ACAN
43 chickenpox 30.3 TNF IL1B CRP
44 coxa vara 30.3 PRG4 MMP13 COL2A1 COL10A1
45 bone disease 30.3 TNF RUNX2 MMP13 MIR140 GDF5 COMP
46 pain agnosia 30.3 TNF IL1B CRP
47 connective tissue disease 30.3 TNF SOX9 RUNX2 MMP3 MMP13 MIR140
48 anterior uveitis 30.3 TNF IL1B CRP
49 hydrarthrosis 30.2 MMP3 ADAMTS5
50 pharyngitis 30.2 TNF IL1B CRP

Graphical network of the top 20 diseases related to Cartilage Disease:



Diseases related to Cartilage Disease
Sources

Symptoms & Phenotypes for Cartilage Disease

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UMLS symptoms related to Cartilage Disease:


back pain; sciatica; muscle cramp

MGI Mouse Phenotypes related to Cartilage Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 10.18 ACAN ADAMTS5 COL10A1 COL2A1 COMP GDF5
2 growth/size/body region MP:0005378 10.17 ACAN ADAMTS3 COL10A1 COL2A1 COMP GDF5
3 craniofacial MP:0005382 9.96 ACAN ADAMTS3 COL10A1 COL2A1 IHH IL1B
4 cardiovascular system MP:0005385 9.93 ACAN ADAMTS3 COL2A1 COMP CRP IHH
5 immune system MP:0005387 9.77 ACAN ADAMTS3 ADAMTS5 COL10A1 COL2A1 COMP
6 skeleton MP:0005390 9.55 ACAN ADAMTS3 ADAMTS4 ADAMTS5 COL10A1 COL2A1
Sources

Drugs & Therapeutics for Cartilage Disease

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Drugs for Cartilage Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Glucosamine Approved, Investigational Phase 4 3416-24-8 318324 439213
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
5
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
6
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
7
Denosumab Approved Phase 4 615258-40-7
8 Fibrin Tissue Adhesive Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Antipyretics Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Cyclooxygenase 2 Inhibitors Phase 4
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Analgesics, Non-Narcotic Phase 4
15
Chondroitin Phase 4 9007-27-6 14389182
16 Adjuvants, Immunologic Phase 4
17 Viscosupplements Phase 4
18 Immunologic Factors Phase 4
19 Protective Agents Phase 4
20 Anti-Arrhythmia Agents Phase 4
21 Sodium Channel Blockers Phase 4
22 Anesthetics, Local Phase 4
23 Anesthetics Phase 4
24 Diuretics, Potassium Sparing Phase 4
25 Antiviral Agents Phase 4
26 Anti-Infective Agents Phase 4
27 Epinephryl borate Phase 4
28 Expectorants Phase 4
29 Antidotes Phase 4
30 N-monoacetylcystine Phase 4
31 Respiratory System Agents Phase 4
32 Antioxidants Phase 4
33 Pharmaceutical Solutions Phase 4
34
Adalimumab Approved, Experimental Phase 3 331731-18-1
35
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 4112 126941
36
Alfacalcidol Approved, Nutraceutical Phase 3 41294-56-8 5282181
37
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 3 67-97-0, 1406-16-2 5280795 10883523
38 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
39 Vitamins Phase 3
40 Trace Elements Phase 3
41 Calciferol Phase 3
42 Hydroxycholecalciferols Phase 3
43 Micronutrients Phase 3
44 Cola Phase 3
45 Shark Cartilage Phase 3
46
Coal tar Approved Phase 1, Phase 2 8007-45-2
47
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850 155817470
48
Ceftriaxone Approved Phase 2 73384-59-5 5479530
49
Tranexamic acid Approved Phase 2 1197-18-8 5526
50
Losartan Approved Phase 1, Phase 2 114798-26-4 3961

Interventional clinical trials:

(show top 50) (show all 352)
# Name Status NCT ID Phase Drugs
1 A Double-blind, Randomized, Post-marketing Surveillance to Evaluate the Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 The Influence of Hyaluronic Acid Injection Following Knee Arthroscopy Unknown status NCT02640144 Phase 4 Sodium Hyaluronate 1%;Placebo
3 Random Clinical Trial for Comparison of Efficacy and Safety of Simple Microfracture and Modified Microfracture Using Collagen in the Patients With Knee Cartilage Defects Unknown status NCT02539030 Phase 4
4 Immunodeficiency in Cartilage-hair Hypoplasia: Correlation With Pulmonary Disease, Infections and Malignancy Unknown status NCT02383797 Phase 4
5 This Clinical Trial Evaluated the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Patients With Cartilage Defects in Their Ankles. Unknown status NCT02519881 Phase 4
6 A Single-Blind Prospective Parallel Control Group Pilot Study to Assess the Effect of Hylan G-F 20 (Synvisc) Supplementation on Cartilage Preservation in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
7 A Post-marketing Surveillance to Evaluate the Efficacy and Safety of CHONDRON (Autologous Cultured Chondrocyte) Through Arthroscopy in Patients With Knee Cartilage Defects Unknown status NCT02539069 Phase 4
8 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN: a Pilot Study Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
9 This Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) in Patients With Cartilage Defects in Their Knees. Unknown status NCT02539056 Phase 4
10 A Prospective, Longitudinal Within-Patient Evaluation of the Effectiveness (Durability) of Carticel® (Autologous Cultured Chondrocytes) Compared to Non-Carticel Surgical Treatment for Articular Cartilage Defects of the Knee. Completed NCT00158613 Phase 4
11 Effect of Platelet Rich Plasma ( PRP ) Applied During Knee Arthroscopy on Pain, Function and Quality of Life - A RCT With a Follow up of 12 Months Completed NCT02189408 Phase 4
12 Quantifications of Biochemical Changes of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection Using Novel MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) Techniques Completed NCT01895959 Phase 4 Euflexxa
13 The Level of Cartilage Oligomeric Matrix Protein (COMP) and Urinary C-Terminal Telopeptides of Type II Collagen (uCTX-II) After Prolotherapy Intervention and The Functional Outcome in Patient With Knee Osteoarthritis Completed NCT04557943 Phase 4 Prolotherapy;Sodium Hyaluronate
14 Treatment for Knee Osteoarthritis With Injections of Autologous Concentrated Bone Marrow Aspirate at the Bone-cartilage Interface Via Percutaneous. Pilot Study Completed NCT03110666 Phase 4
15 Leukocyte-rich PRP vs Leukocyte-poor PRP for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial Completed NCT02923700 Phase 4
16 A Randomized, Double Blinded, Parallel Group, Placebo-controlled Clinical Trial to Assess the Protective Effect of JOINS on Cartilage in Knee Osteoarthritis Completed NCT01293955 Phase 4 JOINS 200mg;Placebo
17 Platelet-rich Plasma (PRP) vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology: a Randomized Double-blind Controlled Trial Completed NCT01670578 Phase 4
18 Prevention of Cartilage Cell Death Following a Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC) Recruiting NCT03652753 Phase 4 N-acetylcysteine;Saline
19 A Phase IV Randomized, Single-Blind Trial of Liposomal Bupivacaine (Exparel®) for Pain Control in Costal Cartilage Harvest Recruiting NCT05285566 Phase 4 Exparel;Xylocaine
20 Single Dose Subcutaneous Injections of Denosumab for Patients Underwent Cemented Total Knee Arthroplasty. A Randomized Controlled Study on the Effects on Bone Microarchitecture, Skeletal Muscle, Cartilage and Synovium Not yet recruiting NCT05559268 Phase 4 Denosumab 60 MG/ML Injectable Solution [Prolia];Placebo
21 Comparison of the Treatment Results of Knee Osteoarthritis Using Adipose Tissue Mesenchymal Stromal Cells Derived Through Enzymatic Digestion and Mechanically Fragmented Adipose Tissue Not yet recruiting NCT04675359 Phase 4
22 Randomized Evaluation of BST-CarGel Versus Microfracture Alone On Recovery From Distal Femoral Cartilage Lesions Terminated NCT02981355 Phase 4
23 Magnetic Resonance Imaging and Clinical Outcomes After Three Different Treatments for Articular Cartilage Lesions Concomitant With Partial Meniscectomy Terminated NCT00613535 Phase 4
24 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
25 A Phase III Clinical Trial to Evaluate the Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle for 18 Months Unknown status NCT02537067 Phase 3 CHONDRON
26 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
27 A Prospective, Randomized, Open-label, Parallel-group, Multi-center Study to Demonstrate the Superiority of MACI® Versus Arthroscopic Microfracture for the Treatment of Symptomatic Articular Cartilage Defects of the Femoral Condyle Including the Trochlea. Completed NCT00719576 Phase 3
28 An Investigator Clinical Trial to Observe Effects of CHONDRON (Autologous Chondrocytes) for 12 Months in Patients With Ankle Cartilage Defect Completed NCT01050816 Phase 3
29 Matrix-encapsulated Arthroscopic Autologous Chondrocyte Implantation Versus Microfractures for Articular Cartilage Regeneration. Randomised Clinical Trial. Completed NCT01947374 Phase 3
30 Autologous Conditioned Serum: Functional and Clinical Results Using a Novel Disease Modifying Agent for the Management of Knee Osteoarthritis Completed NCT03850080 Phase 2, Phase 3 Autologous Conditioned Serum
31 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
32 Prospective Multicenter Randomized Controlled Trial of ChondroCelect® (Via Autologous Chondrocyte Implantation) vs Microfracture (as Procedure) in the Repair of Symptomatic Cartilaginous Defects of the Femoral Condyles Completed NCT00414700 Phase 3 ChondroCelect implantation
33 Randomized, Open-Label, Multi-Center and Phase 3 Clinical Trial to Compare the Efficacy and Safety of Cartistem® and Microfracture in Patients With Knee Articular Cartilage Injury or Defect Completed NCT01041001 Phase 3
34 Long Term Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Completed NCT01626677 Phase 3
35 Prospective, Randomised, Open Label, Multicentre Phase-III Clinical Trial to Compare the Efficacy and Safety of the Treatment With the Autologous Chondrocyte Transplantation Product co.Don Chondrosphere (ACT3D-CS) With Microfracture in Subjects With Cartilage Defects of the Knee With a Defect Size Between 1 an 4 cm2 Completed NCT01222559 Phase 3 co.don chondrosphere®
36 A Single Center, Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Clinical Trial to Evaluate the Sensitivity of Magnetic Resonance Imaging to Detect Change in Cartilage Structure and Composition in 30 Participants Diagnosed With Osteoarthritis of the Knee and Treated With Collagen Hydrolysate Completed NCT00536302 Phase 2, Phase 3
37 Resurfacing Articular Cartilage With Mesenchymal Stem Cells Transplantation in Patients With Knee Joint Osteoarthritis Affected by Rheumatoid Arthritis: Randomized Triple Blind Clinical Trial Phase II/III (ACRCT) Completed NCT01873625 Phase 2, Phase 3
38 Role of Vitamin D (Alphacalcidol) Supplement to Reduce Pain and Cartilage Oligomeric Matrix Protein Serum Levels in Geriatric Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Study Completed NCT04405960 Phase 3 Alfacalcidol 1 MCG Oral Capsule;Sugar pill
39 Phase III Evaluation Of Benefin Shark Cartilage In Patients With Advanced Cancer Completed NCT00026117 Phase 3 BenFin
40 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
41 Safety and Efficacy of NOVOCART 3D in the Treatment of Articular Cartilage Defects Following Failure on Microfracture Recruiting NCT03219307 Phase 3
42 A Phase 3, Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART 3D Compared ot Microfracture in the Treatment of Articular Cartilage Defects Recruiting NCT01957722 Phase 3
43 Randomized Controlled Trial Comparing Clinical Outcomes of Instant MSC Product Accompanying Autologous Chondron Transplantation (IMPACT) for Focal Articular Cartilage Lesions of the Knee to Conservative Treatment Recruiting NCT04236739 Phase 3 Instant MSC Product accompanying Autologous Chondron Transplantation
44 A Prospective Randomized Controlled Multicenter Phase-III Clinical Study to Evaluate the Safety and Effectiveness of NOVOCART® 3D Plus Compared to the Standard Procedure Microfracture in the Treatment of Articular Cartilage Defects of the Knee Active, not recruiting NCT01656902 Phase 3 NOVOCART® 3D plus
45 A Multi-Center, Active-Controlled, Open-Label, Phase III Trial to Compare the Efficacy and Safety for Treatment of Autologous Chondrocytes Implantation With CartiLife Versus Microfracture for Patients With Knee Chondral Defects Active, not recruiting NCT05051332 Phase 3 Autologous Chondrocyte Implantation (CartiLife®)
46 Prospective, Multicenter, Single-arm Phase III Clinical Trial to Evaluate the Efficacy and Safety of NOVOCART® Inject Plus in the Treatment of Cartilage Defects of the Knee Active, not recruiting NCT03319797 Phase 3 NOVOCART® Inject plus
47 Randomized Controlled Trial to Evaluate the Efficacy of a Neocartilage Implant in the Management of ICRS Grade 3 to 4 Articular Cartilage Lesions of the Knee Terminated NCT01400607 Phase 3
48 Delayed Gadolinium-enhanced Magnetic Resonance (MR) Imaging of Cartilage - A Pilot Study to Measure the Effect of Adalimumab Plus MTX Versus Placebo Plus MTX on Cartilage in Early RA Patients Terminated NCT02150473 Phase 3 Adalimumab;Placebo
49 A Randomized Comparison of NeoCart to Microfracture for the Repair of Articular Cartilage Injuries in the Knee Terminated NCT01066702 Phase 3
50 Evaluation of the Composite of Cancellous and Demineralized Bone Plug (CR-Plug) for Repair of Focal Cartilage Lesions in the Femoral Condyle Terminated NCT00793104 Phase 3

Search NIH Clinical Center for Cartilage Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


CHONDROITIN SODIUM
Chondroitin Sulfates

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Cartilage Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cartilage Disease:
A scaold seeded with chondrocytes and bone marrow-derived mononuclear cells for cartilage defects
ChondroArt, chondrocytes for damaged cartilage
Cultivated chondrocytes for treatment of cartilage defects in the knee
NeoCart, collagen scaffold seeded with chondrocytes for knee defect
Embryonic/Adult Cultured Cells Related to Cartilage Disease:
Bone marrow-derived mononuclear cells (family) PMIDs: 23489921
Chondrocytes (ChondroArt) PMIDs: 12097986 24258021
Chondrocyte progenitor cells

Cochrane evidence based reviews: cartilage diseases

Sources

Genetic Tests for Cartilage Disease

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Sources

Anatomical Context for Cartilage Disease

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Organs/tissues related to Cartilage Disease:

FMA: Cartilage
MalaCards : Bone Marrow, Bone, Skin, Thyroid, Trachea, Skeletal Muscle, Endothelial
Sources

Publications for Cartilage Disease

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Articles related to Cartilage Disease:

(show top 50) (show all 30542)
# Title Authors PMID Year
1
Relationship between Outerbridge Scale and Chondropathy Femorotibial Joint in Relation to Gender and Age-The Use of 1.5T and 3.0T MRI Scanners. 62 41
36422173 2022
2
The regulatory activities of MALAT1 in the development of bone and cartilage diseases. 62 41
36452326 2022
3
Two phenotypes of chronic recurrent multifocal osteomyelitis with different patterns of bone involvement. 41
36456962 2022
4
Deletions in the COL10A1 gene are not associated with skeletal changes in dogs. 53 62
16845471 2006
5
Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia. 53 62
15880705 2005
6
Position of single amino acid substitutions in the collagen triple helix determines their effect on structure of collagen fibrils. 53 62
15522781 2004
7
Bone/cartilage targeted hydrogel: Strategies and applications. 62
36406248 2023
8
Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction. 62
36474659 2023
9
Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field. 62
36263100 2023
10
"Genetic scissors" CRISPR/Cas9 genome editing cutting-edge biocarrier technology for bone and cartilage repair. 62
36263098 2023
11
High frame rate deformation analysis of knee cartilage by spiral dualMRI and relaxation mapping. 62
36300860 2023
12
Dynamic Deformation Calculation of Articular Cartilage and Cells Using Resonance-Driven Laser Scanning Microscopy. 62
36000913 2023
13
Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product. 62
35846847 2023
14
Nanoengineered hydrogels as 3D biomimetic extracellular matrix with injectable and sustained delivery capability for cartilage regeneration. 62
35600973 2023
15
Thyroid Cartilage Compression Causing Bow Hunter's Syndrome. 62
35152775 2023
16
Systematic review of articular cartilage derived chondroprogenitors for cartilage repair in animal models. 62
36387762 2023
17
A robust, low swelling, and lipid-lubricated hydrogel for bionic articular cartilage substitute. 62
36088692 2023
18
Decellularization of Articular Cartilage: A Hydrochloric Acid-Based Strategy. 62
36355300 2023
19
Minimum design requirements for a poroelastic mimic of articular cartilage. 62
36343521 2023
20
Articular Cartilage Imaging in the Context of the Superficial Chondrocyte Spatial Organization (SCSO) as a Surrogate Marker for Functional Pathology. 62
36355297 2023
21
Thermogelling hydrogel charge and lower critical solution temperature influence cellular infiltration and tissue integration in an ex vivo cartilage explant model. 62
36053984 2023
22
The Expression of αvβ3 and Osteopontin in Osteoarthritic Knee Cartilage and Their Correlations With Disease Severity and Chondrocyte Senescence. 62
36121292 2023
23
Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy. 62
36355289 2023
24
Cartilage Tissue Engineering: An Introduction. 62
36355280 2023
25
A Mouse Model of Acute Cartilage Injury and Repair. 62
36355303 2023
26
Articular Cartilage Chondroprogenitors: Isolation and Directed Differentiation. 62
36355283 2023
27
Histological Preparation and Evaluation of Cartilage Specimens. 62
36355296 2023
28
Isolation of Chondrons from Hyaline Cartilage. 62
36355282 2023
29
Purification and Isolation of Proteins from Hyaline Cartilage. 62
36355295 2023
30
Unconfined Compression Experimental Protocol for Cartilage Explants and Hydrogel Constructs: From Sample Preparation to Mechanical Characterization. 62
36355298 2023
31
The catabolic-to-anabolic shift seen in the canine osteoarthritic cartilage treated with knee joint distraction occurs after the distraction period. 62
36313973 2023
32
Towards a load bearing hydrogel: A proof of principle in the use of osmotic pressure for biomimetic cartilage constructs. 62
36371992 2023
33
Uniparental parthenogenetic embryonic stem cell derivatives adaptable for bone and cartilage regeneration. 62
36228838 2023
34
The role of hypertrophic chondrocytes in regulation of the cartilage-to-bone transition in fracture healing. 62
36105852 2022
35
Effectiveness of Absorbable Plates for the Treatment of Nasal Septal Cartilage Fractures. 62
36416690 2022
36
Differential gene co-expression network analyses reveal novel molecules associated with transcriptional dysregulation of key biological processes in osteoarthritis knee cartilage. 62
36474801 2022
37
Associations of human femoral condyle cartilage structure and composition with viscoelastic and constituent-specific material properties at different stages of osteoarthritis. 62
36442429 2022
38
Molecular crosstalk between articular cartilage, meniscus, synovium, and subchondral bone in osteoarthritis. 62
36464496 2022
39
280 mT static magnetic field promotes the growth of postpartum condylar cartilage. 62
36469671 2022
40
Autologous Costal Cartilage Grafting for a Large Osteochondral Lesion of the Femoral Head: A 1-Year Single-Arm Study with 2 Additional Years of Follow-up. 62
36325763 2022
41
Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis. 62
36302323 2022
42
Whole-genome RNA sequencing identifies distinct transcriptomic profiles in impingement cartilage between patients with femoroacetabular impingement and hip osteoarthritis. 62
36463522 2022
43
Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering. 62
36420054 2022
44
Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels. 62
36388453 2022
45
Magnetic resonance imaging predictors (cartilage, osteophytes and meniscus) of prevalent and 3-year incident medial and lateral tibiofemoral knee joint tenderness and patellofemoral grind. 62
36456949 2022
46
Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism. 62
36178309 2022
47
Scaffold-free Tracheal Engineering via a Modular Strategy Based on Cartilage and Epithelium Sheets. 62
36461102 2022
48
Rongjin Niantong Fang ameliorates cartilage degeneration by regulating the SDF-1/CXCR4-p38MAPK signalling pathway. 62
36428240 2022
49
The role of Platelet-Rich Plasma (PRP) intraarticular injections in restoring articular cartilage of osteoarthritic knees. A systematic review and meta-analysis. 62
36474791 2022
50
Characterization of intra-tissue strain fields in articular cartilage explants during post-loading recovery using high frequency ultrasound. 62
36375264 2022
Sources

Variations for Cartilage Disease

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Sources

Expression for Cartilage Disease

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Search GEO for disease gene expression data for Cartilage Disease.
Sources

Pathways for Cartilage Disease

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Pathways related to Cartilage Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.67 TNF SOX9 PRG4 IL1B IHH GDF5
2
Collagen chain trimerization 66
Show member pathways
 12.67 MMP3 MMP13 COL2A1 COL10A1 ADAMTS3
3
Extracellular matrix organization 66
Show member pathways
 12.3 MMP3 MMP13 GDF5 COMP COL2A1 COL10A1
4
ECM proteoglycans 66
Show member pathways
 12.02 COMP COL2A1 COL10A1 ACAN
5
Matrix metalloproteinases 74
Show member pathways
 11.75 TNF MMP3 MMP13
6
Spinal cord injury 74
11.72 TNF SOX9 IL1B COL2A1 ACAN
7
Dendritic Cells Developmental Lineage Pathway 65
11.6 TNF RUNX2 IL1B
8
Mesenchymal Stem Cells and Lineage-specific Markers 65
11.53 ACAN COL2A1 GDF5 RUNX2 SOX9
10
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.5 IL1B MMP3 TNF
11
Cell adhesion_ECM remodeling 22
11.47 MMP3 MMP13 COL2A1
12
Endochondral ossification 74
Show member pathways
 11.38 SOX9 RUNX2 MMP13 IHH COL2A1 COL10A1
13
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.31 TNF RUNX2 IL1B
14
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.22 RUNX2 MMP13 IHH
15
Articular Cartilage Extracellular Matrix 65
11.17 COMP COL2A1 ACAN
16
Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway 74
11.06 IL1B MMP3 TNF
17
Oligodendrocyte specification and differentiation, leading to myelin components for CNS 74
10.99 TNF SOX9 IL1B
18
G-protein signaling_Rap2B regulation pathway 22
10.77 TNF PRG4 IL1B GDF5 COL2A1 COL10A1
Sources

GO Terms for Cartilage Disease

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Cellular components related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.3 ACAN ADAMTS3 ADAMTS4 ADAMTS5 COL10A1 COL2A1
2 collagen-containing extracellular matrix GO:0062023 10.16 PRG4 COMP COL2A1 COL10A1 ADAMTS5 ADAMTS4
3 extracellular space GO:0005615 10.12 ADAMTS3 ADAMTS4 ADAMTS5 COL10A1 COL2A1 COMP
4 extracellular matrix GO:0031012 9.62 MMP3 MMP13 IHH COMP COL2A1 COL10A1

Biological processes related to Cartilage Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.36 TNF SOX9 RUNX2 MIR140 IL1B CRP
2 proteolysis GO:0006508 10.29 MMP3 MMP13 IHH ADAMTS5 ADAMTS4 ADAMTS3
3 collagen catabolic process GO:0030574 10.08 ADAMTS3 MMP13 MMP3
4 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.05 TNF IL1B COL2A1
5 cellular response to BMP stimulus GO:0071773 10.04 COL2A1 RUNX2 SOX9
6 extracellular matrix disassembly GO:0022617 10.03 MMP3 MMP13 ADAMTS5 ADAMTS4
7 endochondral ossification GO:0001958 10.02 RUNX2 MMP13 COL2A1
8 negative regulation of chondrocyte differentiation GO:0032331 10 GDF5 IHH SOX9
9 collagen fibril organization GO:0030199 10 COMP COL2A1 ADAMTS3 ACAN
10 positive regulation of chondrocyte differentiation GO:0032332 9.95 GDF5 RUNX2 SOX9
11 negative regulation of mesenchymal cell apoptotic process GO:2001054 9.92 SOX9 GDF5
12 anterior head development GO:0097065 9.9 SOX9 COL2A1
13 positive regulation of fever generation GO:0031622 9.89 TNF IL1B
14 cartilage condensation GO:0001502 9.89 SOX9 COL2A1 ACAN
15 chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003413 9.88 SOX9 IHH
16 ossification GO:0001503 9.88 SOX9 RUNX2 IHH COMP COL2A1
17 cartilage development GO:0051216 9.87 SOX9 IHH GDF5 COMP COL2A1
18 sequestering of triglyceride GO:0030730 9.86 TNF IL1B
19 vascular endothelial growth factor production GO:0010573 9.85 TNF IL1B ADAMTS3
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.84 TNF IL1B
21 skeletal system development GO:0001501 9.83 ACAN ADAMTS4 COL10A1 COL2A1 COMP IHH
22 chondrocyte differentiation GO:0002062 9.81 SOX9 RUNX2 IHH GDF5 COL2A1
23 otic vesicle development GO:0071599 9.79 SOX9 COL2A1
24 chondrocyte development GO:0002063 9.73 ACAN COMP RUNX2 SOX9
25 extracellular matrix organization GO:0030198 9.55 TNF SOX9 MMP3 MMP13 COL2A1 COL10A1

Molecular functions related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.92 COMP COL2A1 COL10A1 ACAN
2 endopeptidase activity GO:0004175 9.86 MMP3 MMP13 ADAMTS5 ADAMTS3
3 peptidase activity GO:0008233 9.85 ADAMTS3 ADAMTS4 ADAMTS5 IHH MMP13 MMP3
4 metalloendopeptidase activity GO:0004222 9.65 MMP3 MMP13 ADAMTS5 ADAMTS4 ADAMTS3
5 metallopeptidase activity GO:0008237 9.23 MMP3 MMP13 ADAMTS5 ADAMTS4 ADAMTS3
Sources

Sources for Cartilage Disease

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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