Aliases & Classifications for Cartilage Disease

MalaCards integrated aliases for Cartilage Disease:

Name: Cartilage Disease 38 12 15
Cartilage Diseases 55 44 73
Cartilage Disorders 43
Cartilage Disorder 12
Chondropathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1222
MeSH 44 D002357
SNOMED-CT 68 50927007
UMLS 73 C0007302

Summaries for Cartilage Disease

MedlinePlus : 43 Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. It also gives shape and support to other parts of your body, such as your ears, nose and windpipe. Healthy cartilage helps you move by allowing your bones to glide over each other. It also protects bones by preventing them from rubbing against each other. Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. It can also lead to joint damage and deformity. Causes of cartilage problems include Tears and injuries, such as sports injuries Genetic factors Other disorders, such as some types of arthritis Osteoarthritis results from breakdown of cartilage. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Cartilage Disease, also known as cartilage diseases, is related to osteochondritis dissecans and relapsing polychondritis, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Cartilage Disease is COL10A1 (Collagen Type X Alpha 1 Chain), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM proteoglycans. The drugs Hyaluronic acid and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow, and related phenotypes are cellular and immune system

Wikipedia : 76 Cartilage is a resilient and smooth elastic tissue, a rubber-like padding that covers and protects the... more...

Related Diseases for Cartilage Disease

Diseases related to Cartilage Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 osteochondritis dissecans 30.3 ACAN COMP
2 relapsing polychondritis 30.3 COMP CRP
3 osteoarthritis 29.8 ACAN COL2A1 COMP
4 chondromalacia 28.7 COMP GSTO1 IL1RN SMUG1 TET2 TNFRSF10A
5 coxa vara 10.2 COL10A1 COL2A1
6 spondyloepimetaphyseal dysplasia, strudwick type 10.2 COL10A1 COL2A1
7 legg-calve-perthes disease 10.2
8 pyle disease 10.2 COL10A1 COL2A1
9 achondrogenesis, type ia 10.2 ACAN COL2A1
10 simpson-golabi-behmel syndrome, type 1 10.2 ACAN COL2A1
11 spondyloepiphyseal dysplasia with congenital joint dislocations 10.2 ACAN COL2A1
12 spondylocarpotarsal synostosis syndrome 10.2 COL10A1 COL2A1
13 bone deterioration disease 10.2 ACAN COL2A1
14 ischemic bone disease 10.1 ACAN COL2A1
15 palindromic rheumatism 10.1 CRP TNFRSF10A
16 cryopyrin-associated periodic syndrome 10.1 CRP IL1RN
17 skeletal dysplasias 10.1 COL2A1 COMP
18 acute cholangitis 10.1 CRP IL1RN
19 hyper-igd syndrome 10.1 CRP IL1RN
20 schnitzler syndrome 10.1 CRP IL1RN
21 tenosynovitis 10.1 COMP CRP
22 tendinitis 10.1 COMP CRP
23 metaphyseal chondrodysplasia, schmid type 10.1 COL10A1 COMP
24 spinal stenosis 10.1 ACAN COL2A1
25 kniest dysplasia 10.1 COL2A1 COMP
26 bone chondrosarcoma 10.1 ACAN COMP
27 diastrophic dysplasia 10.1 COL2A1 COMP
28 malignant acrospiroma 10.1 COL2A1 SMUG1
29 bone structure disease 10.1 ACAN COL2A1
30 gastrointestinal tuberculosis 10.1 CRP SMUG1
31 aortitis 10.1 CRP SMUG1
32 patella, chondromalacia of 10.1 COMP GSTO1
33 adult-onset still's disease 10.1 CRP IL1RN
34 premature chromatid separation trait 10.1
35 pulmonary aspergilloma 10.1 CRP SMUG1
36 tuberculous peritonitis 10.1 CRP SMUG1
37 xanthogranulomatous pyelonephritis 10.1 CRP SMUG1
38 lemierre's syndrome 10.1 CRP SMUG1
39 endocardium disease 10.1 CRP SMUG1
40 intermittent explosive disorder 10.1 CRP SMUG1
41 epiphyseal dysplasia, multiple, 1 10.1 ACAN COMP
42 exanthem 10.1 CRP IL1RN
43 bone disease 10.1 ACAN COL10A1 COL2A1
44 osteochondrosis 10.1
45 kienbock's disease 10.1
46 epiphysiolysis of the hip 10.1
47 pseudoachondroplasia 10.1 ACAN COMP
48 achondroplasia 10.1 ACAN COMP
49 reactive arthritis 10.0 COMP CRP
50 spondyloepiphyseal dysplasia congenita 10.0 COL10A1 COL2A1 COMP

Graphical network of the top 20 diseases related to Cartilage Disease:



Diseases related to Cartilage Disease

Symptoms & Phenotypes for Cartilage Disease

UMLS symptoms related to Cartilage Disease:


back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Cartilage Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 COL10A1 COL2A1 COMP IL1RN SMUG1 TET2
2 immune system MP:0005387 9.17 COL10A1 COL2A1 COMP CRP IL1RN TET2

Drugs & Therapeutics for Cartilage Disease

Drugs for Cartilage Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 9004-61-9 53477741
2 Pharmaceutical Solutions Phase 4,Phase 1,Not Applicable
3 Immunologic Factors Phase 4,Phase 2,Phase 1,Not Applicable
4 Adjuvants, Immunologic Phase 4,Phase 2,Not Applicable
5 Viscosupplements Phase 4,Phase 2,Not Applicable
6 Protective Agents Phase 4,Phase 2,Phase 1,Not Applicable
7
Ketoprofen Approved, Vet_approved Phase 3 22071-15-4 3825
8 Fibrin Tissue Adhesive Phase 3,Phase 2,Not Applicable
9 Anesthetics Phase 2, Phase 3,Not Applicable
10 Peripheral Nervous System Agents Phase 3
11 Analgesics, Non-Narcotic Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Analgesics Phase 3,Not Applicable
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Cyclooxygenase Inhibitors Phase 3
16 Antirheumatic Agents Phase 3,Phase 1,Phase 2
17 Mitogens Phase 3,Not Applicable
18
Aldesleukin Approved Phase 2,Phase 1 85898-30-2, 110942-02-4
19
Vidarabine Approved, Investigational Phase 2 24356-66-9 32326 21704
20
Fludarabine Approved Phase 2 75607-67-9, 21679-14-1 30751
21
Cyclophosphamide Approved, Investigational Phase 2,Phase 1 6055-19-2, 50-18-0 2907
22
Mesna Approved, Investigational Phase 2,Phase 1 3375-50-6 598
23
Cisplatin Approved Phase 1, Phase 2 15663-27-1 2767 441203 84093
24 Antiviral Agents Phase 2,Phase 1,Not Applicable
25 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
26 Coagulants Phase 1, Phase 2,Early Phase 1
27 Anticoagulants Phase 1, Phase 2
28 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
29 Immunosuppressive Agents Phase 2,Phase 1
30 Antineoplastic Agents, Alkylating Phase 2,Phase 1
31 Antimetabolites, Antineoplastic Phase 2,Phase 1
32 Antimetabolites Phase 2,Phase 1
33 Anti-HIV Agents Phase 2,Phase 1
34 Anti-Retroviral Agents Phase 2,Phase 1
35 Alkylating Agents Phase 2,Phase 1
36 Immunoglobulins Phase 1, Phase 2
37 Antibodies Phase 1, Phase 2
38 Antibodies, Monoclonal Phase 1, Phase 2
39
Abatacept Approved Phase 1 332348-12-6 10237
40
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
41
Carboplatin Approved Phase 1 41575-94-4 10339178 38904 498142
42
Etoposide Approved Phase 1 33419-42-0 36462
43
Gemcitabine Approved Phase 1 95058-81-4 60750
44 Daminozide Phase 1 1596-84-5
45 Vaccines Phase 1
46 Antineoplastic Agents, Phytogenic Phase 1
47 Albumin-Bound Paclitaxel Phase 1
48 Antimitotic Agents Phase 1
49 Topoisomerase Inhibitors Phase 1
50 Etoposide phosphate Phase 1

Interventional clinical trials:

(show top 50) (show all 136)
# Name Status NCT ID Phase Drugs
1 the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle Unknown status NCT02519881 Phase 4
2 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
3 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
4 Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology Completed NCT01670578 Phase 4
5 Smith & Nephew's European Trufit Study Completed NCT01246635 Phase 4
6 Radiofrequency-Based Debridement vs. Mechanical Debridement for the Treatment of Articular Cartilage Lesions Not yet recruiting NCT03678948 Phase 4
7 Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD) Withdrawn NCT01283737 Phase 4
8 Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional Microfracture Unknown status NCT01498029 Phase 3
9 Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle Unknown status NCT02537067 Phase 3 CHONDRON
10 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
11 Effects of CHONDRON (Autologous Chondrocytes) With Ankle Cartilage Defect Completed NCT01050816 Phase 3
12 Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee Completed NCT00719576 Phase 3
13 Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect Completed NCT01626677 Phase 3
14 Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain Completed NCT00351104 Phase 3 Ketoprofen Topical Patch 20%
15 Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury Completed NCT00765700 Phase 3 Topical Ketoprofen 10% Cream;Topical Placebo Cream
16 Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis Completed NCT00352625 Phase 3 Ketoprofen Topical Patch 20%
17 A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects. Completed NCT02993510 Phase 3
18 A Study of MACI in Patients Aged 10 to <17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Recruiting NCT03588975 Phase 3
19 NOVOCART 3D Treatment Following Microfracture Failure Recruiting NCT03219307 Phase 3
20 Confirmatory Study of NeoCart in Knee Cartilage Repair Active, not recruiting NCT01066702 Phase 3
21 Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects Active, not recruiting NCT01656902 Phase 3 NOVOCART® 3D plus
22 ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782 Phase 2, Phase 3
23 Neocartilage Implant to Treat Cartilage Lesions of the Knee Terminated NCT01400607 Phase 3
24 Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis Terminated NCT00426985 Phase 3 Ketoprofen Topical Patch 20%
25 Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
26 Platelet Rich Plasma Injection for Knee Pain Completed NCT01747018 Phase 1, Phase 2
27 Mesenchymal Stem Cells in Knee Cartilage Injuries Completed NCT02118519 Phase 2
28 Effect of Autologous Peripheral Blood Stem Cell Treatment on Articular Cartilage Regeneration Completed NCT01076673 Phase 2 Hyaluronic Acid
29 Study to Prevent Cartilage Damage Following Acute Knee Injury. Completed NCT00332254 Phase 1, Phase 2 Anakinra
30 Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects Completed NCT01733186 Phase 1, Phase 2
31 Adult Stem Cell Therapy for Repairing Articular Cartilage in Gonarthrosis Completed NCT01227694 Phase 1, Phase 2
32 Efficacy and Safety Study of Intra-Articular Injections of Autologous Peripheral Blood Stem Cells Following Subchondral Drilling Surgery for the Treatment of Articular Cartilage Injury in the Knee Recruiting NCT03101163 Phase 2
33 Iovance Alliance: LN-145 Across Multiple Tumor Types Recruiting NCT03449108 Phase 2 Cyclophosphamide;Fludarabine;IL-2;Mesna
34 Study to Evaluate the Safety and Tolerability of Avelumab in Combination With Other Anti-Cancer Therapies in Patients With Advanced Malignancies Recruiting NCT03217747 Phase 1, Phase 2 Avelumab;Utomilumab;PF-04518600;Cisplatin
35 Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects Active, not recruiting NCT02855073 Phase 2 Sodium Hyaluronate
36 Tocilizumab for Relapsing Polychondritis Withdrawn NCT01104480 Phase 2 Tocilizumab
37 Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects Unknown status NCT00885729 Phase 1
38 Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect Completed NCT02291926 Phase 1
39 Tissue Engineered Nasal Cartilage for Reconstruction of the Alar Lobule Completed NCT01242618 Phase 1
40 Autologous Transplantation of Mesenchymal Stem Cells (MSCs) and Scaffold in Full-thickness Articular Cartilage Completed NCT00850187 Phase 1
41 Study on the Safety of Abatacept in Relapsing Polychondritis Completed NCT01272856 Phase 1 Abatacept
42 Study of Adoptive Immunotherapy Using Autologous CD8+ NY-ESO-1-Specific T Cells and the NY-ESO-1 Immunostimulatory Agents LV305 or CMB305 For Patients With Sarcoma Recruiting NCT03450122 Phase 1 Cyclophosphamide
43 TAK228 With Carbo and Taxol in Advanced Malignancies Recruiting NCT03430882 Phase 1 TAK-228;Paclitaxel;Carboplatin
44 Ex-Vivo Expanded Allogeneic NK Cells For The Treatment Of Pediatric Solid Tumors Recruiting NCT03420963 Phase 1 Cyclophosphamide;Etoposide;Mesna
45 Study to Evaluate the Safety and Tolerability of IACS-010759 in Subjects With Advanced Solid Tumors and Lymphoma Recruiting NCT03291938 Phase 1 IACS-010759
46 Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases Recruiting NCT03093909 Phase 1 Gemcitabine
47 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Suspended NCT02949414 Phase 1
48 Lenvatinib and Capecitabine in Patients With Advanced Malignancies Withdrawn NCT02915172 Phase 1 Lenvatinib;Capecitabine
49 Laryngomalacia Study Withdrawn NCT01782560 Phase 1 Omeprazole;Placebo
50 Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions Unknown status NCT02770209 Not Applicable

Search NIH Clinical Center for Cartilage Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Cartilage Disease cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: cartilage diseases

Genetic Tests for Cartilage Disease

Anatomical Context for Cartilage Disease

MalaCards organs/tissues related to Cartilage Disease:

41
Bone, Skin, Bone Marrow

Publications for Cartilage Disease

Articles related to Cartilage Disease:

(show all 32)
# Title Authors Year
1
A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system. ( 29440889 )
2018
2
Cartilage diseases. ( 29803938 )
2018
3
Stem Cells in Cartilage Diseases and Repair 2018. ( 30140290 )
2018
4
Nonoperative Options for Management of Articular Cartilage Disease. ( 28577705 )
2017
5
PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies. ( 28317389 )
2017
6
Review: Interventions for Cartilage Disease: Current State-of-the-Art and Emerging Technologies. ( 28294573 )
2017
7
The cytokinome in osteoarthritis, a new paradigm in diagnosis and prognosis of cartilage disease. ( 28002903 )
2016
8
Epigenetics of cartilage diseases. ( 26723856 )
2016
9
Runx2 and microRNA regulation in bone and cartilage diseases. ( 27526290 )
2016
10
Biological knee reconstruction for combined malalignment, meniscal deficiency, and articular cartilage disease. ( 25442661 )
2015
11
Acoustic emission diagnosis for human joint cartilage diseases. ( 26899013 )
2015
12
Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra. ( 25264131 )
2014
13
Autologous bone marrow concentrate: review and application of a novel intra-articular orthobiologic for cartilage disease. ( 24113698 )
2013
14
Clinical use of bone marrow, bone marrow concentrate, and expanded bone marrow mesenchymal stem cells in cartilage disease. ( 23030230 )
2013
15
Is cartilage sGAG content related to early changes in cartilage disease? Implications for interpretation of dGEMRIC. ( 22334095 )
2012
16
Don't hedge your bets: hedgehog signaling as a central mediator of endochondral bone development and cartilage diseases. ( 21308758 )
2011
17
The role of physical forces in the management of bone and cartilage diseases and bone consolidation. ( 21970922 )
2011
18
Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla. ( 20633680 )
2010
19
Arthroscopy vs. MRI for a detailed assessment of cartilage disease in osteoarthritis: diagnostic value of MRI in clinical practice. ( 20406481 )
2010
20
Yet more evidence that osteoarthritis is not a cartilage disease. ( 16973787 )
2006
21
Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. ( 16980220 )
2006
22
Neonatal retroviral vector-mediated hepatic gene therapy reduces bone, joint, and cartilage disease in mucopolysaccharidosis VII mice and dogs. ( 15110316 )
2004
23
Fabrication and characterization of nonplanar microelectrode array circuits for use in arthroscopic diagnosis of cartilage diseases. ( 15605864 )
2004
24
The molecular genetics of inherited cartilage disease. ( 11680678 )
2001
25
The pathophysiology of cartilage diseases. ( 17986978 )
2001
26
MRI techniques in early stages of cartilage disease. ( 11041156 )
2000
27
Magnetic resonance imaging of articular cartilage and evaluation of cartilage disease. ( 11041154 )
2000
28
Subchondral bone and cartilage disease: a rediscovered functional unit. ( 11041152 )
2000
29
New genetic treatment for bone and cartilage disease. ( 7657001 )
1995
30
Type II collagen mutations in rare and common cartilage diseases. ( 8024727 )
1994
31
The control of expression of type II collagen: relevance to cartilage disease. ( 1567552 )
1992
32
Delayed formation of proteoglycan aggregate structures in human articular cartilage disease states. ( 7442801 )
1980

Variations for Cartilage Disease

Expression for Cartilage Disease

Search GEO for disease gene expression data for Cartilage Disease.

Pathways for Cartilage Disease

Pathways related to Cartilage Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.11 ACAN COL10A1 COL2A1 COMP
2 11.01 ACAN COMP
3 10.94 ACAN COL10A1 COL2A1
4 10.36 ACAN COL2A1 COMP

GO Terms for Cartilage Disease

Cellular components related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 ACAN COL10A1 COL2A1 COMP CRP IL1RN
2 extracellular matrix GO:0031012 9.26 ACAN COL10A1 COL2A1 COMP
3 collagen-containing extracellular matrix GO:0062023 8.92 ACAN COL10A1 COL2A1 COMP

Biological processes related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 9.26 ACAN COL2A1
2 extracellular matrix organization GO:0030198 9.26 ACAN COL10A1 COL2A1 COMP
3 cartilage condensation GO:0001502 9.16 ACAN COL2A1
4 skeletal system development GO:0001501 8.92 ACAN COL10A1 COL2A1 COMP

Molecular functions related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL10A1 COL2A1
2 extracellular matrix structural constituent GO:0005201 8.92 ACAN COL10A1 COL2A1 COMP

Sources for Cartilage Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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