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MCID: CRT017
MIFTS: 52

Cartilage Disease

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cartilage Disease

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MalaCards integrated aliases for Cartilage Disease:

Name: Cartilage Disease 12 15 37 17
Cartilage Diseases 54 44 70
Cartilage Disorders 42
Cartilage Disorder 12
Chondropathy 12
Cartilage 17

Classifications:

ICD10: 32


External Ids:

Disease Ontology 12 DOID:1222
MeSH 44 D002357
SNOMED-CT 67 50927007
UMLS 70 C0007302
Sources

Summaries for Cartilage Disease

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MedlinePlus : 42 Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. It also gives shape and support to other parts of your body, such as your ears, nose and windpipe. Healthy cartilage helps you move by allowing your bones to glide over each other. It also protects bones by preventing them from rubbing against each other. Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. It can also lead to joint damage and deformity. Causes of cartilage problems include Tears and injuries, such as sports injuries Genetic factors Other disorders, such as some types of arthritis Osteoarthritis results from breakdown of cartilage. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Cartilage Disease, also known as cartilage diseases, is related to multiple epiphyseal dysplasia and achondroplasia, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Cartilage Disease is COL10A1 (Collagen Type X Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Degradation of the extracellular matrix. The drugs Glucosamine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include cartilage, bone and bone marrow, and related phenotypes are cardiovascular system and craniofacial

Disease Ontology : 12 A connective tissue disease that is located in cartilage.

Wikipedia : 73 Cartilage is a resilient and smooth elastic tissue, rubber-like padding that covers and protects the... more...

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Related Diseases for Cartilage Disease

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Diseases related to Cartilage Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1203)
# Related Disease Score Top Affiliating Genes
1 multiple epiphyseal dysplasia 32.2 COMP COL2A1 COL10A1 ACAN
2 achondroplasia 32.1 SOX9 COMP COL2A1 ACAN
3 platyspondylic lethal skeletal dysplasia, torrance type 31.9 COMP COL2A1 COL10A1
4 enchondromatosis, multiple, ollier type 31.8 RUNX2 MMP13 IHH COL2A1 ACAN
5 kashin-beck disease 31.8 TNF IL1B
6 achondrogenesis 31.7 MATN1 COMP COL2A1 COL10A1 ACAN
7 synovial chondromatosis 31.7 SOX9 RUNX2 COL2A1
8 hypochondroplasia 31.7 IHH COL2A1 ACAN
9 spondyloepiphyseal dysplasia with congenital joint dislocations 31.7 COMP COL2A1 ACAN
10 fibrochondrogenesis 31.7 SOX9 COL2A1 ACAN
11 tracheal disease 31.7 SOX9 CRP COL2A1
12 soft tissue sarcoma 31.5 TNF CRP
13 bronchial disease 31.3 TNF IL1B CRP
14 rheumatoid arthritis 31.3 TNF MMP13 IL1B CRP COMP COL2A1
15 connective tissue disease 31.2 TNF RUNX2 MMP13 IL1B CRP COL2A1
16 chondromalacia 31.1 TNFRSF10A TNF MATN1 CRP COMP ACAN
17 pseudoachondroplasia 31.1 MATN1 COMP COL2A1 ACAN
18 otitis media 31.0 TNF IL1B CRP
19 proteasome-associated autoinflammatory syndrome 1 30.9 TNF IL1B CRP
20 patella, chondromalacia of 30.9 COMP COL2A1 ACAN
21 arthropathy 30.9 TNF PRG4 MMP13 IL1B CRP COMP
22 spondylitis 30.9 TNF IL1B CRP
23 bone development disease 30.8 SOX9 RUNX2 IHH COMP COL2A1 COL10A1
24 enthesopathy 30.7 TNF CRP ACAN
25 osteomyelitis 30.7 TNF IL1B CRP
26 metaphyseal dysplasia 30.7 RUNX2 MMP13 COL2A1 COL10A1
27 psoriatic arthritis 30.6 TNF IL1B CRP COMP
28 reactive arthritis 30.5 TNF IL1B CRP COMP
29 spondyloepiphyseal dysplasia congenita 30.5 COMP COL2A1 COL10A1
30 degenerative disc disease 30.5 SOX9 MMP13 ADAMTS5 ADAMTS4 ADAMTS3 ACAN
31 bronchiectasis 30.4 TNF IL1B CRP
32 arthritis 30.4 TNF MMP13 IL1B CRP COMP COL2A1
33 campomelic dysplasia 30.4 SOX9 SOX6 SOX5 RUNX2 MATN1 IHH
34 hypochondrogenesis 30.4 MATN1 COL2A1 ACAN
35 erysipelas 30.3 TNF IL1B CRP
36 coxa vara 30.3 PRG4 MMP13 COL2A1 COL10A1
37 middle ear disease 30.3 TNF IL1B CRP
38 tendinitis 30.3 TNF MMP13 IL1B CRP COMP
39 tenosynovitis 30.3 TNF IL1B CRP
40 spinal stenosis 30.2 MMP13 COL2A1 ACAN
41 pharyngitis 30.2 TNF IL1B CRP
42 osteoporosis 30.1 TNF SOX6 RUNX2 IL1B CRP COL2A1
43 achondrogenesis, type ii 30.1 MATN1 COMP COL2A1 COL10A1 ACAN
44 osteochondrosis 30.1 COMP COL2A1 ACAN
45 exostosis 30.1 MMP13 IHH COL2A1 ADAMTS5 ACAN
46 basal cell carcinoma 30.1 TNF SOX9 MMP13 IL1B IHH
47 exanthem 30.1 TNF IL1B CRP
48 spondylosis 30.1 IL1B CRP ACAN
49 lyme disease 30.0 TNF IL1B CRP
50 bone disease 30.0 TNF RUNX2 MMP13 IL1B COMP COL2A1

Graphical network of the top 20 diseases related to Cartilage Disease:



Diseases related to Cartilage Disease
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Symptoms & Phenotypes for Cartilage Disease

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UMLS symptoms related to Cartilage Disease:


back pain; sciatica; muscle cramp

MGI Mouse Phenotypes related to Cartilage Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 ADAMTS3 COL2A1 COMP CRP IHH IL1B
2 craniofacial MP:0005382 9.96 ADAMTS3 COL10A1 COL2A1 IHH IL1B RUNX2
3 limbs/digits/tail MP:0005371 9.9 ADAMTS5 COL10A1 COL2A1 COMP IHH MMP13
4 no phenotypic analysis MP:0003012 9.5 ADAMTS4 IHH MATN1 RUNX2 SOX9 TNF
5 skeleton MP:0005390 9.5 ADAMTS3 ADAMTS4 ADAMTS5 COL10A1 COL2A1 COMP
Sources

Drugs & Therapeutics for Cartilage Disease

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Drugs for Cartilage Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 153)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
5
Morphine Approved, Investigational Phase 4 57-27-2 5288826
6
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
7 Hylan Phase 4
8
Chondroitin Phase 4 9007-27-6 14389182
9 Cyclooxygenase 2 Inhibitors Phase 4
10 Cyclooxygenase Inhibitors Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Analgesics Phase 4
13 Antipyretics Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Narcotics Phase 4
16 Anesthetics, General Phase 4
17 Anesthetics, Intravenous Phase 4
18 Anesthetics, Local Phase 4
19 Daminozide Phase 4 1596-84-5
20 Protective Agents Phase 4
21 Pharmaceutical Solutions Phase 4
22 Vaccines Phase 4
23 Antiviral Agents Phase 4
24 Anti-Infective Agents Phase 4
25 Respiratory System Agents Phase 4
26 Antidotes Phase 4
27 Antioxidants Phase 4
28 N-monoacetylcystine Phase 4
29 Expectorants Phase 4
30
Adalimumab Approved, Experimental Phase 3 331731-18-1 16219006
31
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
32
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
33
Alfacalcidol Approved, Nutraceutical Phase 3 41294-56-8 5282181
34 Anesthetics Phase 3
35 Cola Phase 3
36 Hydroxycholecalciferols Phase 3
37 Trace Elements Phase 3
38 Micronutrients Phase 3
39 Calciferol Phase 3
40 Shark Cartilage Phase 3
41 Calcium, Dietary Phase 2, Phase 3
42
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
43
Coal tar Approved Phase 1, Phase 2 8007-45-2
44
Tranexamic Acid Approved Phase 2 1197-18-8 5526
45 Strawberry Approved Phase 1, Phase 2
46
Losartan Approved Phase 1, Phase 2 114798-26-4 3961
47
Angiotensin II Approved, Investigational Phase 1, Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198
48
Fisetin Experimental Phase 1, Phase 2 528-48-3
49 Fibrin Tissue Adhesive Phase 1, Phase 2
50 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 400)
# Name Status NCT ID Phase Drugs
1 A Double-blind, Randomized, Post-marketing Surveillance to Evaluate the Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 The Influence of Hyaluronic Acid Injection Following Knee Arthroscopy Unknown status NCT02640144 Phase 4 Sodium Hyaluronate 1%;Placebo
3 Random Clinical Trial for Comparison of Efficacy and Safety of Simple Microfracture and Modified Microfracture Using Collagen in the Patients With Knee Cartilage Defects Unknown status NCT02539030 Phase 4
4 This Clinical Trial Evaluated the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Patients With Cartilage Defects in Their Ankles. Unknown status NCT02519881 Phase 4
5 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN: a Pilot Study Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
6 This Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) in Patients With Cartilage Defects in Their Knees. Unknown status NCT02539056 Phase 4
7 A Post-marketing Surveillance to Evaluate the Efficacy and Safety of CHONDRON (Autologous Cultured Chondrocyte) Through Arthroscopy in Patients With Knee Cartilage Defects Unknown status NCT02539069 Phase 4
8 Leukocyte-rich PRP vs Leukocyte-poor PRP for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial Unknown status NCT02923700 Phase 4
9 A Single-Blind Prospective Parallel Control Group Pilot Study to Assess the Effect of Hylan G-F 20 (Synvisc) Supplementation on Cartilage Preservation in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
10 A Randomized, Double Blinded, Parallel Group, Placebo-controlled Clinical Trial to Assess the Protective Effect of JOINS on Cartilage in Knee Osteoarthritis Completed NCT01293955 Phase 4 JOINS 200mg;Placebo
11 Platelet-rich Plasma (PRP) vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology: a Randomized Double-blind Controlled Trial Completed NCT01670578 Phase 4
12 A Prospective, Longitudinal Within-Patient Evaluation of the Effectiveness (Durability) of Carticel® (Autologous Cultured Chondrocytes) Compared to Non-Carticel Surgical Treatment for Articular Cartilage Defects of the Knee. Completed NCT00158613 Phase 4
13 The Level of Cartilage Oligomeric Matrix Protein (COMP) and Urinary C-Terminal Telopeptides of Type II Collagen (uCTX-II) After Prolotherapy Intervention and The Functional Outcome in Patient With Knee Osteoarthritis Completed NCT04557943 Phase 4 Prolotherapy;Sodium Hyaluronate
14 Quantifications of Biochemical Changes of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection Using Novel MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) Techniques Completed NCT01895959 Phase 4 Euflexxa
15 Ultrasound Guidance or Electrical Nerve Stimulation for Interscalene Brachial Plexus Block: a Randomized, Controlled Trial Completed NCT00702416 Phase 4 Ropivacaine;Paracetamol;Morphine;Fentanyl
16 Multicenter Randomized Controlled Trial for the Treatment of Knee Chondral and Osteochondral Lesions: Marrow Stimulation Techniques vs MaioRegen Completed NCT01282034 Phase 4
17 Randomized Trial of Bupivacaine as Adjuvant for Post-operative Pain in Mohs Micrographic Surgery Recruiting NCT04362566 Phase 4 Bupivacaine
18 Immunodeficiency in Cartilage-hair Hypoplasia: Correlation With Pulmonary Disease, Infections and Malignancy Active, not recruiting NCT02383797 Phase 4
19 Prevention of Cartilage Cell Death Following a Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC) Active, not recruiting NCT03652753 Phase 4 N-acetylcysteine;Saline
20 Treatment for Knee Osteoarthritis With Injections of Autologous Concentrated Bone Marrow Aspirate at the Bone-cartilage Interface Via Percutaneous. Pilot Study Active, not recruiting NCT03110666 Phase 4
21 Magnetic Resonance Imaging and Clinical Outcomes After Three Different Treatments for Articular Cartilage Lesions Concomitant With Partial Meniscectomy Terminated NCT00613535 Phase 4
22 Randomized Evaluation of BST-CarGel Versus Microfracture Alone On Recovery From Distal Femoral Cartilage Lesions Terminated NCT02981355 Phase 4
23 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
24 A Phase III Clinical Trial to Evaluate the Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle for 18 Months Unknown status NCT02537067 Phase 3 CHONDRON
25 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
26 A Pilot Study for Efficacy of BST-CarGel as an Adjunct to Microfracture for the Treatment of Chondral Lesions of the Hip: a Case Control Study Unknown status NCT02540200 Phase 3
27 An Investigator Clinical Trial to Observe Effects of CHONDRON (Autologous Chondrocytes) for 12 Months in Patients With Ankle Cartilage Defect Completed NCT01050816 Phase 3
28 A Prospective, Randomized, Open-label, Parallel-group, Multi-center Study to Demonstrate the Superiority of MACI® Versus Arthroscopic Microfracture for the Treatment of Symptomatic Articular Cartilage Defects of the Femoral Condyle Including the Trochlea. Completed NCT00719576 Phase 3
29 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
30 Randomized, Open-Label, Multi-Center and Phase 3 Clinical Trial to Compare the Efficacy and Safety of Cartistem® and Microfracture in Patients With Knee Articular Cartilage Injury or Defect Completed NCT01041001 Phase 3
31 Prospective, Randomised, Open Label, Multicentre Phase-III Clinical Trial to Compare the Efficacy and Safety of the Treatment With the Autologous Chondrocyte Transplantation Product co.Don Chondrosphere (ACT3D-CS) With Microfracture in Subjects With Cartilage Defects of the Knee With a Defect Size Between 1 an 4 cm2 Completed NCT01222559 Phase 3 co.don chondrosphere®
32 Prospective Multicenter Randomized Controlled Trial of ChondroCelect® (Via Autologous Chondrocyte Implantation) vs Microfracture (as Procedure) in the Repair of Symptomatic Cartilaginous Defects of the Femoral Condyles Completed NCT00414700 Phase 3 ChondroCelect implantation
33 Matrix-encapsulated Arthroscopic Autologous Chondrocyte Implantation Versus Microfractures for Articular Cartilage Regeneration. Randomised Clinical Trial. Completed NCT01947374 Phase 3
34 Role of Vitamin D (Alphacalcidol) Supplement to Reduce Pain and Cartilage Oligomeric Matrix Protein Serum Levels in Geriatric Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Study Completed NCT04405960 Phase 3 Alfacalcidol 1 MCG Oral Capsule;Sugar pill
35 A Single Center, Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Clinical Trial to Evaluate the Sensitivity of Magnetic Resonance Imaging to Detect Change in Cartilage Structure and Composition in 30 Participants Diagnosed With Osteoarthritis of the Knee and Treated With Collagen Hydrolysate Completed NCT00536302 Phase 2, Phase 3
36 Phase III Evaluation Of Benefin Shark Cartilage In Patients With Advanced Cancer Completed NCT00026117 Phase 3 BenFin
37 Resurfacing Articular Cartilage With Mesenchymal Stem Cells Transplantation in Patients With Knee Joint Osteoarthritis Affected by Rheumatoid Arthritis: Randomized Triple Blind Clinical Trial Phase II/III (ACRCT) Completed NCT01873625 Phase 2, Phase 3
38 Phase 3 Study Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty Completed NCT00560664 Phase 3
39 A Study to Evaluate the Effectiveness and Safety of an Implant in the Treatment of Osteoarthritis of the Great Toe Completed NCT00969969 Phase 3
40 Long Term Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Completed NCT01626677 Phase 3
41 Sellick Maneuver Evaluation in Rapid Sequence Induction of General Anesthesia Non Inferiority Trial Completed NCT02080754 Phase 3
42 A Post Approval Study to Evaluate the Safety and Effectiveness of Cartiva Implant in the Treatment of First Metatarsophalangeal Joint Osteoarthritis as Compared to a Control Completed NCT02978573 Phase 3
43 The Role of Spreader Flaps in Preventing of Nasal Obstruction in Primary Rhinoplasty: A Randomized-controlled Trial. Completed NCT01907243 Phase 3
44 Evaluation of Regenerative Medicine Treatment Outcomes With Amniotic Fluid for Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
45 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
46 Safety and Efficacy of NOVOCART 3D in the Treatment of Articular Cartilage Defects Following Failure on Microfracture Recruiting NCT03219307 Phase 3
47 Randomized Controlled Trial Comparing Clinical Outcomes of Instant MSC Product Accompanying Autologous Chondron Transplantation (IMPACT) for Focal Articular Cartilage Lesions of the Knee to Conservative Treatment Recruiting NCT04236739 Phase 3 Instant MSC Product accompanying Autologous Chondron Transplantation
48 A Phase 3, Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART 3D Compared ot Microfracture in the Treatment of Articular Cartilage Defects Recruiting NCT01957722 Phase 3
49 Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Otitis Media Recruiting NCT04761562 Phase 2, Phase 3 Platelet- and extracellular vesicle-rich plasma
50 A Prospective Randomized Controlled Multicenter Phase-III Clinical Study to Evaluate the Safety and Effectiveness of NOVOCART® 3D Plus Compared to the Standard Procedure Microfracture in the Treatment of Articular Cartilage Defects of the Knee Active, not recruiting NCT01656902 Phase 3 NOVOCART® 3D plus

Search NIH Clinical Center for Cartilage Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :


CHONDROITIN SODIUM
Chondroitin Sulfates

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Cartilage Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cartilage Disease:
A scaold seeded with chondrocytes and bone marrow-derived mononuclear cells for cartilage defects
ChondroArt, chondrocytes for damaged cartilage
Cultivated chondrocytes for treatment of cartilage defects in the knee
NeoCart, collagen scaffold seeded with chondrocytes for knee defect
Embryonic/Adult Cultured Cells Related to Cartilage Disease:
Bone marrow-derived mononuclear cells (family) PMIDs: 23489921
Chondrocytes (ChondroArt) PMIDs: 12097986 24258021
Chondrocyte progenitor cells

Cochrane evidence based reviews: cartilage diseases

Sources

Genetic Tests for Cartilage Disease

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Anatomical Context for Cartilage Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Cartilage Disease:

19
Cartilage

MalaCards organs/tissues related to Cartilage Disease:

40
Bone, Bone Marrow, Thyroid, Skin, Heart, Lung, Kidney
Sources

Publications for Cartilage Disease

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Articles related to Cartilage Disease:

(show top 50) (show all 315)
# Title Authors PMID Year
1
A tri-component knee plug for the 3rd generation of autologous chondrocyte implantation. 42
33046760 2020
2
Compensation claims after knee cartilage surgery is rare. A registry-based study from Scandinavia from 2010 to 2015. 42
32384890 2020
3
Periostin interaction with discoidin domain receptor-1 (DDR1) promotes cartilage degeneration. 42
32330138 2020
4
Articular Cartilage Injuries of the Knee: Patient Health Literacy, Expectations for Management, and Clinical Outcomes. 61
30486654 2021
5
Real-Time Quantification of Cartilage Degeneration by GAG-Targeted Cationic Nanoparticles for Efficient Therapeutic Monitoring in Living Mice. 61
33538605 2021
6
The role of stromal cell-derived factor 1 on cartilage development and disease. 61
33253889 2021
7
Comparative anatomy and morphology of the knee in translational models for articular cartilage disorders. Part II: Small animals. 61
33129976 2021
8
Glutathione-S-transferase A3 protein suppresses thiram-induced tibial dyschondroplasia by regulating prostaglandin-related genes expression. 61
33129574 2021
9
Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives. 61
33629260 2021
10
Lipid metabolism in cartilage and its diseases: a concise review of the research progress. 61
33638344 2021
11
Chondrogenesis of human amniotic fluid stem cells in Chitosan-Xanthan scaffold for cartilage tissue engineering. 61
33542256 2021
12
An Update on the Role of Leptin in the Immuno-Metabolism of Cartilage. 61
33673730 2021
13
Quantifying the hydroxyapatite orientation near the ossification front in a piglet femoral condyle using X-ray diffraction tensor tomography. 61
33495539 2021
14
Cartilage Tissue and Therapeutic Strategies for Cartilage Repair. 61
32520688 2021
15
Cartilage Disease of the Patellofemoral Joint: Realignment, Restoration, Replacement. 61
33438917 2021
16
Incidence of concomitant chondral/osteochondral lesions in acute ankle fractures and their effect on clinical outcome: a systematic review and meta-analysis. 61
33128607 2021
17
Extrusion-based printing of chitosan scaffolds and their in vitro characterization for cartilage tissue engineering. 61
32853616 2020
18
Curcumin ameliorates IL-1β-induced apoptosis by activating autophagy and inhibiting the NF-κB signaling pathway in rat primary articular chondrocytes. 61
33377585 2020
19
Mesenchymal stem cells: amazing remedies for bone and cartilage defects. 61
33225992 2020
20
Full wave 3D inverse scattering transmission ultrasound tomography in the presence of high contrast. 61
33214569 2020
21
Gelatin Microsphere for Cartilage Tissue Engineering: Current and Future Strategies. 61
33086577 2020
22
T1rho and T2 mapping of ankle cartilage of female and male ballet dancers. 61
32028774 2020
23
Mesenchymal stromal cells for articular cartilage repair: preclinical studies. 61
32852776 2020
24
Small Non-Coding RNAome of Ageing Chondrocytes. 61
32784773 2020
25
Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF-κB signaling pathway inhibition. 61
32112120 2020
26
Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the "kidney governing bone" theory. 61
32295616 2020
27
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis. 61
32200258 2020
28
Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes. 61
31918067 2020
29
Ganglioside GM3 Up-Regulate Chondrogenic Differentiation by Transform Growth Factor Receptors. 61
32183071 2020
30
Platelet rich plasma for treatment of osteochondral lesions of the talus: A systematic review of clinical trials. 61
32071508 2020
31
Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis. 61
32092942 2020
32
Identification and expression analysis of microRNAs in tibial growth plate of chicken through thiram toxicity. 61
31873907 2020
33
Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair. 61
31789105 2020
34
Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy. 61
32117924 2020
35
Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats. 61
32211385 2020
36
Yam-Containing Serum Promotes Proliferation and Chondrogenic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells and Synthesis of Glycosaminoglycan. 61
31722364 2020
37
DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions. 61
31980739 2020
38
Recent Progress in 3D Printing of Elastic and High-Strength Hydrogels for the Treatment of Osteochondral and Cartilage Diseases. 61
33330436 2020
39
[Correlation between histone methylation level and pathological development of osteoarthritis]. 61
31955544 2019
40
Defective WNT signaling may protect from articular cartilage deterioration - a quantitative MRI study on subjects with a heterozygous WNT1 mutation. 61
31299386 2019
41
Glutamic acid-based dendritic peptides for scaffold-free cartilage tissue engineering. 61
31521812 2019
42
Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies. 61
31455417 2019
43
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases. 61
31220958 2019
44
ADAM8 promotes chondrosarcoma cell migration and invasion by activating the NF-κB/MMP-13 signaling axis. 61
31305294 2019
45
Intra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair. 61
30954618 2019
46
Role of Epigenomics in Bone and Cartilage Disease. 61
30715766 2019
47
Arthroscopic Hip Joint Assessment can Impact the Indications for PAO Surgery. 61
31413688 2019
48
Pre-Clinical Translation of Second Harmonic Microscopy of Meniscal and Articular Cartilage Using a Prototype Nonlinear Microendoscope. 61
30701146 2019
49
The Clinical Evidence Behind Biologic Therapies Promoted at Annual Orthopaedic Meetings: A Systematic Review. 61
30455088 2019
50
Ligustrazine recovers thiram-induced tibial dyschondroplasia in chickens: Involvement of new molecules modulating integrin beta 3. 61
30388538 2019
Sources

Variations for Cartilage Disease

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Expression for Cartilage Disease

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Search GEO for disease gene expression data for Cartilage Disease.
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Pathways for Cartilage Disease

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Pathways related to Cartilage Disease according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.53 TNFRSF10A TNF SOX9 SOX6 SOX5 PRG4
2
Degradation of the extracellular matrix 65
Show member pathways
 12.26 MMP13 MATN1 COMP COL2A1 COL10A1 ADAMTS5
3
Diseases of glycosylation 65
Show member pathways
 11.92 ADAMTS5 ADAMTS4 ADAMTS3 ACAN
4
Spinal Cord Injury 1
11.73 TNF SOX9 IL1B COL2A1 ACAN
5
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.61 SOX9 SOX6 SOX5 RUNX2 COL2A1 ACAN
6
O-glycosylation of TSR domain-containing proteins 65
Show member pathways
 11.59 ADAMTS5 ADAMTS4 ADAMTS3
7
Dendritic Cells Developmental Lineage Pathway 64
11.57 TNF RUNX2 IL1B
8
ECM proteoglycans 65
11.44 MATN1 COMP ACAN
9
Malaria 36
11.37 TNF IL1B COMP
10
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.31 TNF RUNX2 IL1B
11
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 23
11.2 RUNX2 MMP13 IHH
12
Endochondral Ossification 1
11.18 SOX9 SOX6 SOX5 RUNX2 MMP13 IHH
13
Articular Cartilage Extracellular Matrix Pathway 64
11.14 COMP COL2A1 ACAN
14
G-protein signaling_Rap2B regulation pathway 23
10.75 TNF PRG4 IL1B COL2A1 COL10A1 ACAN
Sources

GO Terms for Cartilage Disease

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Cellular components related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10 TNF MMP13 IL1B IHH CRP COMP
2 extracellular region GO:0005576 10 TNF PRG4 MMP13 MATN1 IL1B IHH
3 collagen-containing extracellular matrix GO:0062023 9.61 PRG4 MATN1 COMP COL2A1 COL10A1 ADAMTS5
4 collagen trimer GO:0005581 9.5 MMP13 COL2A1 COL10A1
5 extracellular matrix GO:0031012 9.32 MMP13 MATN1 IHH COMP COL2A1 COL10A1

Biological processes related to Cartilage Disease according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 10.08 MMP13 IHH ADAMTS5 ADAMTS4 ADAMTS3 ACAN
2 positive regulation of gene expression GO:0010628 10.07 TNF SOX9 RUNX2 IL1B CRP
3 regulation of gene expression GO:0010468 10 SOX9 RUNX2 IHH COMP COL2A1
4 central nervous system development GO:0007417 9.88 SOX9 SOX6 COL2A1 ACAN
5 ossification GO:0001503 9.85 SOX9 RUNX2 IHH COMP COL2A1
6 cellular response to mechanical stimulus GO:0071260 9.84 TNFRSF10A SOX9 IL1B
7 cell fate commitment GO:0045165 9.82 SOX9 SOX6 SOX5
8 extracellular matrix disassembly GO:0022617 9.82 MMP13 ADAMTS5 ADAMTS4
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.8 SOX9 SOX6 SOX5
10 collagen fibril organization GO:0030199 9.8 COMP COL2A1 ADAMTS3 ACAN
11 protein kinase B signaling GO:0043491 9.74 TNF SOX9 IL1B
12 cellular response to BMP stimulus GO:0071773 9.73 SOX9 RUNX2 COL2A1
13 chondrocyte differentiation GO:0002062 9.73 SOX9 SOX6 SOX5 RUNX2 MATN1 COL2A1
14 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.72 TNF IL1B COL2A1
15 cartilage condensation GO:0001502 9.72 SOX9 SOX6 SOX5 COL2A1 ACAN
16 chondrocyte development GO:0002063 9.71 SOX9 RUNX2 COMP ACAN
17 endochondral ossification GO:0001958 9.7 RUNX2 MMP13 COL2A1
18 cartilage development GO:0051216 9.7 SOX9 SOX6 SOX5 MMP13 IHH COMP
19 positive regulation of cartilage development GO:0061036 9.69 SOX9 SOX6 SOX5
20 chondrocyte proliferation GO:0035988 9.68 IHH COMP
21 positive regulation of neuroinflammatory response GO:0150078 9.68 TNF IL1B
22 limb bud formation GO:0060174 9.67 SOX9 COL2A1
23 positive regulation of chondrocyte differentiation GO:0032332 9.67 SOX9 SOX6 SOX5 RUNX2
24 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
25 notochord development GO:0030903 9.66 SOX9 COL2A1
26 negative regulation of lipid storage GO:0010888 9.65 TNF CRP
27 growth plate cartilage development GO:0003417 9.65 MMP13 COMP
28 vascular endothelial growth factor production GO:0010573 9.65 TNF IL1B ADAMTS3
29 proteoglycan metabolic process GO:0006029 9.64 IHH COL2A1
30 otic vesicle development GO:0071599 9.63 SOX9 COL2A1
31 positive regulation of chondrocyte proliferation GO:1902732 9.62 SOX9 COMP
32 positive regulation of fever generation GO:0031622 9.62 TNF IL1B
33 chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003413 9.61 SOX9 IHH
34 positive regulation of mesenchymal stem cell differentiation GO:2000741 9.61 SOX9 SOX6 SOX5
35 anterior head development GO:0097065 9.59 SOX9 COL2A1
36 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
37 skeletal system development GO:0001501 9.56 SOX9 RUNX2 IHH COMP COL2A1 COL10A1
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IL1B
39 extracellular matrix organization GO:0030198 9.36 TNF SOX9 MMP13 MATN1 COMP COL2A1

Molecular functions related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.88 MMP13 MATN1 IHH CRP COMP ACAN
2 peptidase activity GO:0008233 9.83 MMP13 IHH ADAMTS5 ADAMTS4 ADAMTS3
3 metallopeptidase activity GO:0008237 9.67 MMP13 ADAMTS5 ADAMTS4 ADAMTS3
4 metalloendopeptidase activity GO:0004222 9.62 MMP13 ADAMTS5 ADAMTS4 ADAMTS3
5 protease binding GO:0002020 9.56 TNFRSF10A TNF COMP ADAMTS4
6 transcription regulatory region sequence-specific DNA binding GO:0000976 9.55 TNF SOX9 SOX6 SOX5 RUNX2
7 proximal promoter sequence-specific DNA binding GO:0000987 9.26 SOX9 SOX6 SOX5 RUNX2
8 extracellular matrix structural constituent GO:0005201 9.02 MATN1 COMP COL2A1 COL10A1 ACAN
Sources

Sources for Cartilage Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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