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MCID: CRT017
MIFTS: 48

Cartilage Disease

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cartilage Disease

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MalaCards integrated aliases for Cartilage Disease:

Name: Cartilage Disease 38 12 15
Cartilage Diseases 55 44 73
Cartilage Disorders 43
Cartilage Disorder 12
Chondropathy 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Cartilage Disease

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MedlinePlus : 43 Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. It also gives shape and support to other parts of your body, such as your ears, nose and windpipe. Healthy cartilage helps you move by allowing your bones to glide over each other. It also protects bones by preventing them from rubbing against each other. Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. It can also lead to joint damage and deformity. Causes of cartilage problems include Tears and injuries, such as sports injuries Genetic factors Other disorders, such as some types of arthritis Osteoarthritis results from breakdown of cartilage. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Cartilage Disease, also known as cartilage diseases, is related to osteochondritis dissecans and osteoarthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Cartilage Disease is COL10A1 (Collagen Type X Alpha 1 Chain), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM proteoglycans. The drugs Hyaluronic acid and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow, and related phenotypes are cellular and immune system

Wikipedia : 76 Cartilage is a resilient and smooth elastic tissue, a rubber-like padding that covers and protects the... more...

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Related Diseases for Cartilage Disease

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Diseases related to Cartilage Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 osteochondritis dissecans 29.7 ACAN COMP
2 osteoarthritis 29.0 ACAN COL2A1 COMP
3 spondyloepimetaphyseal dysplasia, strudwick type 10.7 COL10A1 COL2A1
4 coxa vara 10.7 COL10A1 COL2A1
5 pyle disease 10.7 COL10A1 COL2A1
6 achondrogenesis, type ia 10.5 ACAN COL2A1
7 folic acid deficiency anemia 10.5 CRP TET2
8 palindromic rheumatism 10.5 CRP TNFRSF10A
9 ischemic bone disease 10.4 ACAN COL2A1
10 spondyloepiphyseal dysplasia with congenital joint dislocations 10.4 ACAN COL2A1
11 bone deterioration disease 10.4 ACAN COL2A1
12 ovarian squamous cell carcinoma 10.4 CRP SMUG1
13 aortitis 10.4 CRP SMUG1
14 pulmonary aspergilloma 10.4 CRP SMUG1
15 tuberculous peritonitis 10.4 CRP SMUG1
16 spinal stenosis 10.3 ACAN COL2A1
17 lemierre's syndrome 10.3 CRP SMUG1
18 lipid pneumonia 10.3 CRP SMUG1
19 xanthogranulomatous pyelonephritis 10.3 CRP SMUG1
20 intermittent explosive disorder 10.3 CRP SMUG1
21 endocardium disease 10.3 CRP SMUG1
22 bone structure disease 10.3 ACAN COL2A1
23 cryopyrin-associated periodic syndrome 10.3 CRP IL1RN
24 acute cholangitis 10.3 CRP IL1RN
25 hyper-igd syndrome 10.3 CRP IL1RN
26 adult-onset still's disease 10.2 CRP IL1RN
27 bone disease 10.2 ACAN COL10A1 COL2A1
28 thrombocytosis 10.1 CRP TET2
29 exanthem 10.1 CRP IL1RN
30 legg-calve-perthes disease 10.1
31 kniest dysplasia 10.0 COL2A1 COMP
32 central nervous system vasculitis 10.0 CRP SMUG1 TNFRSF10A
33 diastrophic dysplasia 10.0 COL2A1 COMP
34 tendinitis 10.0 COMP CRP
35 skeletal tuberculosis 10.0 CRP SMUG1 TNFRSF10A
36 relapsing polychondritis 10.0 COMP CRP
37 brucellosis 10.0 CRP IL1RN
38 hypersensitivity reaction type iv disease 9.9 IL1RN SMUG1
39 skeletal dysplasias 9.9 COL2A1 COMP
40 familial mediterranean fever 9.8 CRP IL1RN
41 reactive arthritis 9.8 COMP CRP
42 pseudoachondroplasia 9.8 ACAN COMP
43 spondyloepiphyseal dysplasia congenita 9.8 COL10A1 COL2A1 COMP
44 autoinflammation, lipodystrophy, and dermatosis syndrome 9.8 CRP IL1RN
45 bone development disease 9.8 COL2A1 COMP
46 arthritis 9.7 ACAN COL2A1 IL1RN
47 spondylitis 9.6 CRP IL1RN
48 achondroplasia 9.6 ACAN COMP
49 achondrogenesis, type ii 9.6 ACAN COL2A1 COMP
50 joint disorders 9.6

Graphical network of the top 20 diseases related to Cartilage Disease:



Diseases related to Cartilage Disease
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Symptoms & Phenotypes for Cartilage Disease

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UMLS symptoms related to Cartilage Disease:


back pain, muscle cramp, sciatica

MGI Mouse Phenotypes related to Cartilage Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 COL10A1 COL2A1 COMP IL1RN SMUG1 TET2
2 immune system MP:0005387 9.17 COL10A1 COL2A1 COMP CRP IL1RN TET2
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Drugs & Therapeutics for Cartilage Disease

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Drugs for Cartilage Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 9004-61-9 53477741
2 Pharmaceutical Solutions Phase 4,Phase 1
3 Adjuvants, Immunologic Phase 4,Phase 2,Not Applicable
4 Protective Agents Phase 4,Phase 2,Phase 1,Not Applicable
5 Viscosupplements Phase 4,Phase 2,Not Applicable
6
Ketoprofen Approved, Vet_approved Phase 3 22071-15-4 3825
7 Fibrin Tissue Adhesive Phase 3,Phase 2,Not Applicable
8 Anesthetics Phase 2, Phase 3,Not Applicable
9 Analgesics Phase 3,Not Applicable
10 Analgesics, Non-Narcotic Phase 3
11 Anti-Inflammatory Agents Phase 3
12 Anti-Inflammatory Agents, Non-Steroidal Phase 3
13 Antirheumatic Agents Phase 3,Phase 1,Phase 2
14 Cyclooxygenase Inhibitors Phase 3
15 Peripheral Nervous System Agents Phase 3
16 Mitogens Phase 3,Not Applicable
17
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
18 Anticoagulants Phase 1, Phase 2
19 Coagulants Phase 1, Phase 2,Early Phase 1
20 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
21 Antibodies Phase 1, Phase 2
22 Antibodies, Monoclonal Phase 1, Phase 2
23 Immunoglobulins Phase 1, Phase 2
24
Abatacept Approved Phase 1 332348-12-6 10237
25
Gemcitabine Approved Phase 1 95058-81-4 60750
26
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
27
Etoposide Approved Phase 1 33419-42-0 36462
28
Mesna Approved, Investigational Phase 1 3375-50-6 598
29 Anti-Infective Agents Phase 1,Not Applicable
30 Antiviral Agents Phase 1,Not Applicable
31 Daminozide Phase 1 1596-84-5
32 Immunosuppressive Agents Phase 1
33 Antimetabolites Phase 1
34 Antimetabolites, Antineoplastic Phase 1
35 Proton Pump Inhibitors Phase 1,Not Applicable
36 Alkylating Agents Phase 1
37 Antineoplastic Agents, Alkylating Phase 1
38 Antineoplastic Agents, Phytogenic Phase 1
39 Etoposide phosphate Phase 1
40 Topoisomerase Inhibitors Phase 1
41
Acyclovir Approved Not Applicable 59277-89-3 2022
42
Povidone-iodine Approved Not Applicable 25655-41-8
43
Interferon beta-1a Approved, Investigational 145258-61-3 6438354
44
Menthol Approved Not Applicable 2216-51-5 16666
45
Tranexamic Acid Approved Early Phase 1 1197-18-8 5526
46
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
47
Acetaminophen Approved Not Applicable 103-90-2 1983
48
Codeine Approved, Illicit Not Applicable 76-57-3 5284371
49
Ethanol Approved Not Applicable 64-17-5 702
50
Ibuprofen Approved Not Applicable 15687-27-1 3672

Interventional clinical trials:

(show top 50) (show all 131)
# Name Status NCT ID Phase Drugs
1 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
3 Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology Completed NCT01670578 Phase 4
4 Smith & Nephew's European Trufit Study Completed NCT01246635 Phase 4
5 the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle Recruiting NCT02519881 Phase 4
6 Post-op Treatment With Hyaluronic Acid Injections Terminated NCT01256788 Phase 4
7 Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD) Withdrawn NCT01283737 Phase 4
8 Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional Microfracture Unknown status NCT01498029 Phase 3
9 Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle Unknown status NCT02537067 Phase 3 CHONDRON
10 The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects Unknown status NCT00891501 Phase 2, Phase 3
11 Effects of CHONDRON (Autologous Chondrocytes) With Ankle Cartilage Defect Completed NCT01050816 Phase 3
12 Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee Completed NCT00719576 Phase 3
13 Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect Completed NCT01626677 Phase 3
14 Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain Completed NCT00351104 Phase 3 Ketoprofen Topical Patch 20%
15 Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury Completed NCT00765700 Phase 3 Topical Ketoprofen 10% Cream;Topical Placebo Cream
16 Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis Completed NCT00352625 Phase 3 Ketoprofen Topical Patch 20%
17 A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects. Completed NCT02993510 Phase 3
18 Confirmatory Study of NeoCart in Knee Cartilage Repair Active, not recruiting NCT01066702 Phase 3
19 Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects Active, not recruiting NCT01656902 Phase 3 NOVOCART® 3D plus
20 ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782 Phase 2, Phase 3
21 NOVOCART 3D Treatment Following Microfracture Failure Not yet recruiting NCT03219307 Phase 3
22 Neocartilage Implant to Treat Cartilage Lesions of the Knee Terminated NCT01400607 Phase 3
23 Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis Terminated NCT00426985 Phase 3 Ketoprofen Topical Patch 20%
24 Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects Unknown status NCT02855073 Phase 2 Sodium Hyaluronate
25 Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
26 Platelet Rich Plasma Injection for Knee Pain Completed NCT01747018 Phase 1, Phase 2
27 Mesenchymal Stem Cells in Knee Cartilage Injuries Completed NCT02118519 Phase 2
28 Effect of Autologous Peripheral Blood Stem Cell Treatment on Articular Cartilage Regeneration Completed NCT01076673 Phase 2 Hyaluronic Acid
29 Study to Prevent Cartilage Damage Following Acute Knee Injury. Completed NCT00332254 Phase 1, Phase 2 Anakinra
30 Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects Completed NCT01733186 Phase 1, Phase 2
31 Adult Stem Cell Therapy for Repairing Articular Cartilage in Gonarthrosis Completed NCT01227694 Phase 1, Phase 2
32 Efficacy and Safety Study of Intra-Articular Injections of Autologous Peripheral Blood Stem Cells Following Subchondral Drilling Surgery for the Treatment of Articular Cartilage Injury in the Knee Recruiting NCT03101163 Phase 2
33 Iovance Alliance: LN-145 Across Multiple Tumor Types Recruiting NCT03449108 Phase 2 Cyclophosphamide;Fludarabine;IL-2;Mesna
34 Study to Evaluate the Safety and Tolerability of Avelumab in Combination With Other Anti-Cancer Therapies in Patients With Advanced Malignancies Recruiting NCT03217747 Phase 1, Phase 2 Avelumab;Utomilumab;PF-04518600;Cisplatin
35 Tocilizumab for Relapsing Polychondritis Withdrawn NCT01104480 Phase 2 Tocilizumab
36 Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects Unknown status NCT00885729 Phase 1
37 Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect Completed NCT02291926 Phase 1
38 Tissue Engineered Nasal Cartilage for Reconstruction of the Alar Lobule Completed NCT01242618 Phase 1
39 Autologous Transplantation of Mesenchymal Stem Cells (MSCs) and Scaffold in Full-thickness Articular Cartilage Completed NCT00850187 Phase 1
40 Study on the Safety of Abatacept in Relapsing Polychondritis Completed NCT01272856 Phase 1 Abatacept
41 TAK228 With Carbo and Taxol in Advanced Malignancies Recruiting NCT03430882 Phase 1 TAK-228;Paclitaxel;Carboplatin
42 Study to Evaluate the Safety and Tolerability of IACS-010759 in Subjects With Advanced Solid Tumors and Lymphoma Recruiting NCT03291938 Phase 1 IACS-010759
43 Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases Recruiting NCT03093909 Phase 1 Gemcitabine
44 Study of Adoptive Immunotherapy Using Autologous CD8+ NY-ESO-1-Specific T Cells and the NY-ESO-1 Immunostimulatory Agents LV305 or CMB305 For Patients With Sarcoma Not yet recruiting NCT03450122 Phase 1 Cyclophosphamide
45 Ex-Vivo Expanded Allogeneic NK Cells For The Treatment Of Pediatric Solid Tumors Not yet recruiting NCT03420963 Phase 1 Cyclophosphamide;Etoposide;Mesna
46 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Suspended NCT02949414 Phase 1
47 Lenvatinib and Capecitabine in Patients With Advanced Malignancies Withdrawn NCT02915172 Phase 1 Lenvatinib;Capecitabine
48 Laryngomalacia Study Withdrawn NCT01782560 Phase 1 Omeprazole;Placebo
49 Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions Unknown status NCT02770209 Not Applicable
50 Prevalence of Chondromalacia Patella Among Adolescent Dancers - Correlation Between Symptoms and Sonography Findings Unknown status NCT02606942

Search NIH Clinical Center for Cartilage Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Cartilage Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cartilage Disease:
A sca?old seeded with chondrocytes and bone marrow-derived mononuclear cells for cartilage defects
ChondroArt
Cultivated chondrocytes for treatment of cartilage defects in the knee
NeoCart, collagen scaffold seeded with chondrocytes for knee defect
Embryonic/Adult Cultured Cells Related to Cartilage Disease:
Bone marrow-derived mononuclear cells (family) PMIDs: 23489921
Chondrocytes (ChondroArt PMIDs: 12097986 24258021
Chondrocyte progenitor cells

Cochrane evidence based reviews: cartilage diseases

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Genetic Tests for Cartilage Disease

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Anatomical Context for Cartilage Disease

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MalaCards organs/tissues related to Cartilage Disease:

41
Bone, Skin, Bone Marrow, T Cells, Lung, Nk Cells
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Publications for Cartilage Disease

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Articles related to Cartilage Disease:

(show all 20)
# Title Authors Year
1
Nonoperative Options for Management of Articular Cartilage Disease. ( 28577705 )
2017
2
PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies. ( 28317389 )
2017
3
Review: Interventions for Cartilage Disease: Current State-of-the-Art and Emerging Technologies. ( 28294573 )
2017
4
The cytokinome in osteoarthritis, a new paradigm in diagnosis and prognosis of cartilage disease. ( 28002903 )
2016
5
Biological knee reconstruction for combined malalignment, meniscal deficiency, and articular cartilage disease. ( 25442661 )
2015
6
Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra. ( 25264131 )
2014
7
Autologous bone marrow concentrate: review and application of a novel intra-articular orthobiologic for cartilage disease. ( 24113698 )
2013
8
Clinical use of bone marrow, bone marrow concentrate, and expanded bone marrow mesenchymal stem cells in cartilage disease. ( 23030230 )
2013
9
Is cartilage sGAG content related to early changes in cartilage disease? Implications for interpretation of dGEMRIC. ( 22334095 )
2012
10
Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla. ( 20633680 )
2010
11
Arthroscopy vs. MRI for a detailed assessment of cartilage disease in osteoarthritis: diagnostic value of MRI in clinical practice. ( 20406481 )
2010
12
Yet more evidence that osteoarthritis is not a cartilage disease. ( 16973787 )
2006
13
Neonatal retroviral vector-mediated hepatic gene therapy reduces bone, joint, and cartilage disease in mucopolysaccharidosis VII mice and dogs. ( 15110316 )
2004
14
The molecular genetics of inherited cartilage disease. ( 11680678 )
2001
15
MRI techniques in early stages of cartilage disease. ( 11041156 )
2000
16
Magnetic resonance imaging of articular cartilage and evaluation of cartilage disease. ( 11041154 )
2000
17
Subchondral bone and cartilage disease: a rediscovered functional unit. ( 11041152 )
2000
18
New genetic treatment for bone and cartilage disease. ( 7657001 )
1995
19
The control of expression of type II collagen: relevance to cartilage disease. ( 1567552 )
1992
20
Delayed formation of proteoglycan aggregate structures in human articular cartilage disease states. ( 7442801 )
1980
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Variations for Cartilage Disease

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Expression for Cartilage Disease

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Search GEO for disease gene expression data for Cartilage Disease.
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Pathways for Cartilage Disease

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Pathways related to Cartilage Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 66
Show member pathways
 12.11 ACAN COL10A1 COL2A1 COMP
2
ECM proteoglycans 66
11.01 ACAN COMP
3
Endochondral Ossification 1
10.94 ACAN COL10A1 COL2A1
4
Articular Cartilage Extracellular Matrix Pathway 65
10.36 ACAN COL2A1 COMP
Sources

GO Terms for Cartilage Disease

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Cellular components related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 COL2A1 COMP CRP IL1RN KRT86
2 extracellular region GO:0005576 9.43 ACAN COL10A1 COL2A1 COMP CRP IL1RN
3 extracellular matrix GO:0031012 8.8 ACAN COL2A1 COMP

Biological processes related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.26 ACAN COL10A1 COL2A1 COMP
2 collagen catabolic process GO:0030574 9.16 COL10A1 COL2A1
3 skeletal system development GO:0001501 8.92 ACAN COL10A1 COL2A1 COMP

Molecular functions related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.65 ACAN COL10A1 COL2A1 COMP CRP IL1RN
2 extracellular matrix structural constituent GO:0005201 8.8 ACAN COL2A1 COMP
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Sources for Cartilage Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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