MCID: CRT017
MIFTS: 54

Cartilage Disease

Categories: Bone diseases, Ear diseases, Smell/Taste diseases

Aliases & Classifications for Cartilage Disease

MalaCards integrated aliases for Cartilage Disease:

Name: Cartilage Disease 12 15 37 17
Cartilage Diseases 54 43 71
Cartilage Disorders 42
Cartilage Disorder 12
Chondropathy 12
Cartilage 17

Classifications:



External Ids:

Disease Ontology 12 DOID:1222
MeSH 43 D002357
SNOMED-CT 67 50927007
UMLS 71 C0007302

Summaries for Cartilage Disease

MedlinePlus : 42 Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. It also gives shape and support to other parts of your body, such as your ears, nose and windpipe. Healthy cartilage helps you move by allowing your bones to glide over each other. It also protects bones by preventing them from rubbing against each other. Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. It can also lead to joint damage and deformity. Causes of cartilage problems include Tears and injuries, such as sports injuries Genetic factors Other disorders, such as some types of arthritis Osteoarthritis results from breakdown of cartilage. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Cartilage Disease, also known as cartilage diseases, is related to multiple epiphyseal dysplasia and achondroplasia, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Cartilage Disease is COL10A1 (Collagen Type X Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Degradation of the extracellular matrix. The drugs Simvastatin and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are cardiovascular system and cellular

Wikipedia : 74 Cartilage is a resilient and smooth elastic tissue, a rubber-like padding that covers and protects the... more...

Related Diseases for Cartilage Disease

Diseases related to Cartilage Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1097)
# Related Disease Score Top Affiliating Genes
1 multiple epiphyseal dysplasia 32.8 SOX9 COMP COL2A1 ACAN
2 achondroplasia 32.8 SOX9 COMP COL2A1 ACAN
3 tracheomalacia 32.8 SOX9 COL2A1
4 skeletal dysplasias 32.7 COMP COL2A1
5 rheumatoid arthritis 32.7 MMP13 CRP COMP COL2A1 ADAMTS4 ACAN
6 tracheal disease 32.7 SOX9 CRP COL2A1
7 achondrogenesis 32.5 MATN1 COMP COL2A1 COL10A1 ACAN
8 spondyloepiphyseal dysplasia with congenital joint dislocations 32.5 COMP COL2A1 ACAN
9 hypochondroplasia 32.4 IHH COMP COL2A1
10 enchondromatosis, multiple, ollier type 32.4 RUNX2 MMP13 IHH COL2A1 ACAN
11 dyssegmental dysplasia, silverman-handmaker type 32.3 COL2A1 BMP2
12 fibrochondrogenesis 32.0 SOX9 COL2A1 BMP2 ACAN
13 brachyolmia 32.0 SOX9 COL2A1 ACAN
14 synovial chondromatosis 32.0 SOX9 RUNX2 COL2A1 BMP2
15 campomelic dysplasia 31.9 SOX9 SOX6 SOX5 COL2A1 COL10A1 ACAN
16 connective tissue disease 31.7 RUNX2 MMP13 CRP COL2A1 BMP2 ACAN
17 chondromyxoid fibroma 31.5 SOX9 COL10A1
18 chondromalacia 31.5 TNFRSF10A MATN1 CRP COMP ACAN
19 arthropathy 31.4 MMP13 CRP COMP COL2A1 ACAN
20 pseudoachondroplasia 31.2 MATN1 COMP COL2A1 ACAN
21 odontochondrodysplasia 31.2 SOX9 SOX6 SOX5 RUNX2 MATN1 IHH
22 scheuermann disease 30.8 RPL34 COL2A1
23 tendinitis 30.7 MMP13 CRP COMP
24 ankylosis 30.7 RUNX2 CRP BMP2
25 avascular necrosis 30.6 COL2A1 BMP2
26 pyle disease 30.6 RUNX2 COMP COL2A1 COL10A1
27 coxa vara 30.6 MMP13 COL2A1 COL10A1
28 spondyloepiphyseal dysplasia congenita 30.5 COMP COL2A1 COL10A1
29 hypochondrogenesis 30.5 MATN1 COL2A1 ACAN
30 enthesopathy 30.4 CRP ACAN
31 arthritis 30.4 MMP13 CRP COMP COL2A1 ADAMTS5 ADAMTS4
32 clear cell chondrosarcoma 30.3 SOX9 RUNX2
33 spondyloepimetaphyseal dysplasia, strudwick type 30.3 COL2A1 COL10A1
34 bone development disease 30.3 SOX9 RUNX2 IHH COMP COL2A1 COL10A1
35 thanatophoric dysplasia, type i 30.3 IHH COMP COL2A1
36 achondrogenesis, type ii 30.3 MATN1 COMP COL2A1 ACAN
37 periodontitis 30.2 RUNX2 MMP13 CRP
38 stickler syndrome 30.1 SOX9 COL2A1 ACAN
39 spinal stenosis 30.1 RPL34 MMP13 COL2A1 ACAN
40 osteochondrosis 30.1 IHH COL2A1 COL10A1 ACAN
41 chondrodysplasia, grebe type 30.1 SOX5 COL2A1
42 relapsing polychondritis 30.0 MATN1 CRP COMP
43 cleft palate, isolated 30.0 SOX9 RUNX2 IHH COL2A1 BMP2
44 tympanosclerosis 30.0 COL2A1 BMP2
45 otospondylomegaepiphyseal dysplasia 29.9 COMP COL2A1 COL10A1
46 spondyloepimetaphyseal dysplasia, matrilin-3 related 29.9 COMP COL2A1 ACAN
47 brittle bone disorder 29.8 RUNX2 COMP COL2A1 COL10A1 BMP2 ACAN
48 diastrophic dysplasia 29.8 COMP COL2A1 BMP2
49 osteochondritis dissecans 29.7 MMP13 COMP BMP2 ACAN
50 bone disease 29.7 RUNX2 MMP13 COMP COL2A1 COL10A1 BMP2

Graphical network of the top 20 diseases related to Cartilage Disease:



Diseases related to Cartilage Disease

Symptoms & Phenotypes for Cartilage Disease

UMLS symptoms related to Cartilage Disease:


back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Cartilage Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.14 ADAMTS3 BMP2 COL2A1 COMP CRP IHH
2 cellular MP:0005384 10.11 ADAMTS3 ADAMTS5 BMP2 COL10A1 COL2A1 COMP
3 craniofacial MP:0005382 9.97 ADAMTS3 BMP2 COL10A1 COL2A1 IHH RUNX2
4 limbs/digits/tail MP:0005371 9.9 ADAMTS5 BMP2 COL10A1 COL2A1 COMP IHH
5 digestive/alimentary MP:0005381 9.8 ADAMTS3 BMP2 COL2A1 IHH RUNX2 SOX5
6 normal MP:0002873 9.56 ADAMTS4 ADAMTS5 BMP2 COL2A1 COMP SOX5
7 skeleton MP:0005390 9.47 ADAMTS3 ADAMTS4 ADAMTS5 BMP2 COL10A1 COL2A1

Drugs & Therapeutics for Cartilage Disease

Drugs for Cartilage Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 370)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Etanercept Approved, Investigational Phase 4 185243-69-0
3
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
4
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
5 Orange Approved Phase 4
6
Adalimumab Approved Phase 4 331731-18-1 16219006
7
Acetaminophen Approved Phase 4 103-90-2 1983
8
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
9
Liraglutide Approved Phase 4 204656-20-2 44147092
10
Ibuprofen Approved Phase 4 15687-27-1 3672
11
Zinc Approved, Investigational Phase 4 7440-66-6 32051
12
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
13
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
14
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
15
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
16
Tranexamic Acid Approved Phase 4 1197-18-8 5526
17
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
18
Racepinephrine Approved Phase 4 329-65-7 838
19
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
20
Morphine Approved, Investigational Phase 4 57-27-2 5288826
21
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
22
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
23
Deslorelin Investigational, Vet_approved Phase 4 57773-65-6
24 Plasminogen Activator Inhibitor 1 Phase 4
25 Hypolipidemic Agents Phase 4
26 Anticholesteremic Agents Phase 4
27 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
28 Lipid Regulating Agents Phase 4
29 Anti-Inflammatory Agents Phase 4
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4
31 Analgesics, Non-Narcotic Phase 4
32 Cyclooxygenase Inhibitors Phase 4
33 Anesthetics Phase 4
34 Anesthetics, Local Phase 4
35 Diacetylrhein Phase 4
36 Factor VIII Phase 4
37 Antipyretics Phase 4
38
Chondroitin Phase 4 9007-27-6 53477707
39
Rosmarinic acid Phase 4 537-15-5 5281792
40 Platelet Aggregation Inhibitors Phase 4
41 Serine Proteinase Inhibitors Phase 4
42 Incretins Phase 4
43 Hypoglycemic Agents Phase 4
44 Neurotransmitter Agents Phase 4
45 Astringents Phase 4
46 Anesthetics, General Phase 4
47 Adjuvants, Anesthesia Phase 4
48 Anesthetics, Intravenous Phase 4
49 Anesthetics, Dissociative Phase 4
50 Excitatory Amino Acid Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 1030)
# Name Status NCT ID Phase Drugs
1 A Double-blind, Randomized, Post-marketing Surveillance to Evaluate the Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 A Single-Blind Prospective Parallel Control Group Pilot Study to Assess the Effect of Hylan G-F 20 (Synvisc) Supplementation on Cartilage Preservation in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
3 The Influence of Hyaluronic Acid Injection Following Knee Arthroscopy Unknown status NCT02640144 Phase 4 Sodium Hyaluronate 1%;Placebo
4 Random Clinical Trial for Comparison of Efficacy and Safety of Simple Microfracture and Modified Microfracture Using Collagen in the Patients With Knee Cartilage Defects Unknown status NCT02539030 Phase 4
5 This Clinical Trial Evaluated the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Patients With Cartilage Defects in Their Ankles. Unknown status NCT02519881 Phase 4
6 A Post-marketing Surveillance to Evaluate the Efficacy and Safety of CHONDRON (Autologous Cultured Chondrocyte) Through Arthroscopy in Patients With Knee Cartilage Defects Unknown status NCT02539069 Phase 4
7 This Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) in Patients With Cartilage Defects in Their Knees. Unknown status NCT02539056 Phase 4
8 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
9 Intra-Articular Injections of Hyaluronan Versus 20 Ml NaCl Versus Placebo in Treatment of Knee Osteoarthritis: a Randomised, Double-Blind, Placebo Controlled Single Centre Trial. Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
10 A Randomized, Double-blind Study to Evaluate the Efficacy of Iguratimod Versus Placebo in Patients With Rheumatoid Arthritis on Magnetic Resonance Imaging (MRI) Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
11 Validation of a Device for Performing Valgus and Varus Stress X-rays of the Knee Unknown status NCT02444663 Phase 4
12 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN: a Pilot Study Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
13 The Assessment of the Effect of Vitamin D Supplementation on the Serum of AGES and Endothelialy Factors and Gene Expression of Glyoxalase Enzyme and YKL-40 Factor in PBMC Cells in the Patients With Type 2 Diabetes . Unknown status NCT03008057 Phase 4
14 The Effects of Simvastatin in Patients With Chronic Obstructive Pulmonary Disease Unknown status NCT00680641 Phase 4 Simvastatin;Placebo
15 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
16 A Prospective, Multi-Center, Randomized, Single-Blind, Controlled Study Comparing the Trufit CB (Cartilage Bone) Implant to Microfracture for the Treatment of Patients With Single, Isolated Defects of the Knee Completed NCT01246635 Phase 4
17 Platelet-rich Plasma (PRP) vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology: a Randomized Double-blind Controlled Trial Completed NCT01670578 Phase 4
18 Early Post-op. Viscosupplementation After Primary Anterior Cruciate Ligament (ACL) Reconstruction: a Randomized, Placebo Controlled Trial Completed NCT02630407 Phase 4
19 Quantifications of Biochemical Changes of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection Using Novel MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) Techniques Completed NCT01895959 Phase 4 Euflexxa
20 A Prospective, Longitudinal Within-Patient Evaluation of the Effectiveness (Durability) of Carticel® (Autologous Cultured Chondrocytes) Compared to Non-Carticel Surgical Treatment for Articular Cartilage Defects of the Knee. Completed NCT00158613 Phase 4
21 A Randomized, Double Blinded, Parallel Group, Placebo-controlled Clinical Trial to Assess the Protective Effect of JOINS on Cartilage in Knee Osteoarthritis Completed NCT01293955 Phase 4 JOINS 200mg;Placebo
22 Double Blind, Randomized, Multicentre, Placebo Controlled Study to Assess the Efficacy and Safety of Reflex Plus™ in Osteoarthritis Completed NCT02655939 Phase 4
23 Phase 4 Study of Diacerein as Adjuvant to Diclofenac Sodium in Indian Patients of OA Knee Completed NCT01120015 Phase 4 diacerein
24 Adalimumab in Axial Spondyloarthritis. An Investigation of Whole-body MRI, MRI of Sacroiliac Joints and Spine and Soluble Biomarkers of Joint Inflammation and Damage. Completed NCT01029847 Phase 4 Adalimumab;Placebo
25 Efficacy and Safety of the Infiltration of Autologous Plasma Rich in Growth Factors (PRGF) in the Symptomatic Treatment of Knee Osteoarthritis Completed NCT00782197 Phase 4
26 Human Clinical Trial to Investigate the Effects of High Rosmarinic Acid Spearmint Tea on Markers of Pain, Physical Function and Disease Activity in Osteoarthritis of the Knee Completed NCT01380015 Phase 4
27 Effect of Intra-articular Steroids on Structural Progression of Knee OA: A Randomized Controlled Trial Completed NCT01230424 Phase 4 Triamcinolone Acetonide;0.9% Sodium Chloride Injection as Placebo
28 Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis Following Liraglutide Treatment, Investigating the Impact on Inflammation Completed NCT02928679 Phase 4 Liraglutide 3 mg (Saxenda);Liraglutide 3 mg placebo
29 Does Anesthetic Contribute to Symptomatic Relief in Corticosteroid Injections for Knee Osteoarthritis? A Double-Blind Randomized Trial Comparing Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections Completed NCT02576249 Phase 4 Ropivacaine;Normal saline;Methylprednisolone
30 Effect of Interventions on Progression of Knee Osteoarthritis - a Comparison of Effect of Glucosamine/Chondroitin or Diacerin Vs Placebo: Measured by Clinical, Radiological and Biochemical Parameters Completed NCT02178137 Phase 4 Diacerien;Glucosamine/Chondroitin;Placebo
31 Single Center, Randomized, Double-Blind, Placebo-Controlled Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab Completed NCT01144143 Phase 4 Infliximab;Placebo;Standard of Care: Methylprednisolone acetate
32 Phase 4 Study of Glucosamine Sulphate in the Treatment for Chronic Low Back Pain Patients With Degenerative Lumbar MRI Findings Completed NCT00404079 Phase 4 Glucosamine sulphate;Placebo
33 The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial Completed NCT03825133 Phase 4 Hyaluronic Acid
34 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
35 Spa Therapy in Knee Osteoarthritis: Study on Cost/Effectiveness - Cost/Utility and Possible Mechanisms of Action Completed NCT01538043 Phase 4
36 Efficacy and Safety of Intra-Articular Injections of Durolane® in the Treatment of Osteoarthritis in the Knee Completed NCT00731289 Phase 4 hyaluronic acid;triamcinolone
37 Acute Effect of Resistance Training in Inflammatory Markers in Women With Rheumatoid Arthritis Completed NCT02401958 Phase 4
38 Proximal Tibial Open Wedge Osteotomy. Stability and Healing Evaluated in a Clinical Prospective, Randomized Trial Using RSA. Completed NCT00319280 Phase 4
39 The Effect of Alfentanil on the Lower Esophageal Sphincter During Anesthesia Induction - a Study in Volunteers Completed NCT01199458 Phase 4 alfentanil;saline
40 Ultrasound Guidance or Electrical Nerve Stimulation for Interscalene Brachial Plexus Block: a Randomized, Controlled Trial Completed NCT00702416 Phase 4 Ropivacaine;Paracetamol;Morphine;Fentanyl
41 Best Effect of Viscosupplementation With Hyaluronic Acid and Triamcinolone in Patients With Knee Osteoarthritis. Prospective Randomized Study Between Two Different Applications Regimens Completed NCT01824485 Phase 4 viscosupplementation 1+1+1;viscosupplementation 3 at once
42 Multicenter Randomized Controlled Trial for the Treatment of Knee Chondral and Osteochondral Lesions: Marrow Stimulation Techniques vs MaioRegen Completed NCT01282034 Phase 4
43 Patterned Electrical Neuromuscular Stimulation and Therapeutic Exercise for Osteoarthritis of the Knee: Pilot Study Completed NCT00701506 Phase 4
44 Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome Completed NCT03586154 Phase 4 ketamine and bupivacaine injection
45 The Efficacy of Demineralized Bone Matrix and Autogenous Bone Graft in Accelerated Fracture Healing in Closed Tibia Fracture Completed NCT00299052 Phase 4
46 Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section. A Double Blind, Randomized, Placebo Controlled Trial. Completed NCT03068260 Phase 4 Ropivacaine;Saline;Acetaminophen;Ibuprofen 400Mg Tablet / Celebra 100 Mg tablet;Morphine
47 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of 12 Months Subcutaneous Tocilizumab in Rheumatoid Arthritis Phase IV Prospective Multicentrique Study Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
48 Leukocyte-rich PRP vs Leukocyte-poor PRP for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial Recruiting NCT02923700 Phase 4
49 Clinical Outcomes Following Randomization of Steroid Concentration in Patients With Glenohumeral Osteoarthritis Recruiting NCT03586687 Phase 4 Triamcinolone
50 Treatment for Knee Osteoarthritis With Injections of Autologous Concentrated Bone Marrow Aspirate at the Bone-cartilage Interface Via Percutaneous. Pilot Study Active, not recruiting NCT03110666 Phase 4

Search NIH Clinical Center for Cartilage Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


CHONDROITIN SODIUM
Chondroitin Sulfates

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Cartilage Disease cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: cartilage diseases

Genetic Tests for Cartilage Disease

Anatomical Context for Cartilage Disease

MalaCards organs/tissues related to Cartilage Disease:

40
Bone, Bone Marrow, Skin, Thyroid, Heart, Lung, Testes

Publications for Cartilage Disease

Articles related to Cartilage Disease:

(show top 50) (show all 285)
# Title Authors PMID Year
1
Assessment of TNF-α inhibitors in airway involvement of relapsing polychondritis: A systematic review. 42
31689839 2019
2
Tracheobronchial involvement of relapsing polychondritis. 42
31323366 2019
3
ULTRASONOGRAPHIC EVALUATION OF FEMORAL CARTILAGE THICKNESS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME. 42
31363331 2019
4
Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair. 61
31789105 2020
5
DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions. 61
31980739 2020
6
Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes. 61
31918067 2020
7
[Correlation between histone methylation level and pathological development of osteoarthritis]. 61
31955544 2019
8
Identification and expression analysis of microRNAs in tibial growth plate of chicken through thiram toxicity. 61
31873907 2019
9
Defective WNT signaling may protect from articular cartilage deterioration - a quantitative MRI study on subjects with a heterozygous WNT1 mutation. 61
31299386 2019
10
Glutamic acid-based dendritic peptides for scaffold-free cartilage tissue engineering. 61
31521812 2019
11
Yam-Containing Serum Promotes Proliferation and Chondrogenic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells and Synthesis of Glycosaminoglycan. 61
31722364 2019
12
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases. 61
31220958 2019
13
Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies. 61
31455417 2019
14
ADAM8 promotes chondrosarcoma cell migration and invasion by activating the NF-κB/MMP-13 signaling axis. 61
31305294 2019
15
Intra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair. 61
30954618 2019
16
Role of Epigenomics in Bone and Cartilage Disease. 61
30715766 2019
17
Osteoarthritis as an organ disease: from the cradle to the grave. 61
30698270 2019
18
Ligustrazine recovers thiram-induced tibial dyschondroplasia in chickens: Involvement of new molecules modulating integrin beta 3. 61
30388538 2019
19
The Clinical Evidence Behind Biologic Therapies Promoted at Annual Orthopaedic Meetings: A Systematic Review. 61
30455088 2019
20
Arthroscopic Hip Joint Assessment can Impact the Indications for PAO Surgery. 61
31413688 2019
21
Proteomic Identification and Time-Course Monitoring of Secreted Proteins During Expansion of Human Mesenchymal Stem/Stromal in Stirred-Tank Bioreactor. 61
31297369 2019
22
4-Phenylbutyric Acid Reduces Endoplasmic Reticulum Stress in Chondrocytes That Is Caused by Loss of the Protein Disulfide Isomerase ERp57. 61
31781343 2019
23
Pre-Clinical Translation of Second Harmonic Microscopy of Meniscal and Articular Cartilage Using a Prototype Nonlinear Microendoscope. 61
30701146 2019
24
Novel Hybrid Gels Made of High and Low Molecular Weight Hyaluronic Acid Induce Proliferation and Reduce Inflammation in an Osteoarthritis In Vitro Model Based on Human Synoviocytes and Chondrocytes. 61
31179322 2019
25
Treatment of Articular Cartilage Defects: Focus on Tissue Engineering. 61
30348681 2018
26
Articular Cartilage Injuries of the Knee: Patient Health Literacy, Expectations for Management, and Clinical Outcomes. 61
30486654 2018
27
On incorporating osmotic prestretch/prestress in image-driven finite element simulations of cartilage. 61
30031245 2018
28
Cartilage diseases. 61
29803938 2018
29
Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors. 61
29726060 2018
30
Human Engineered Cartilage and Decellularized Matrix as an Alternative to Animal Osteoarthritis Model. 61
30960663 2018
31
Curcumin protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in vitro. 61
29604245 2018
32
Adiponectin Downregulates TNF-α Expression in Degenerated Intervertebral Discs. 61
28767622 2018
33
Radiographic, computed tomographic, and arthroscopic diagnosis of radioulnar incongruence in dogs with medial coronoid disease. 61
29536555 2018
34
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics. 61
28827187 2018
35
miR-27b promotes type II collagen expression by targetting peroxisome proliferator-activated receptor-γ2 during rat articular chondrocyte differentiation. 61
29187585 2018
36
Ghrelin protects against osteoarthritis through interplay with Akt and NF-κB signaling pathways. 61
29070587 2018
37
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development. 61
29402405 2018
38
Different Forms of ER Stress in Chondrocytes Result in Short Stature Disorders and Degenerative Cartilage Diseases: New Insights by Cartilage-Specific ERp57 Knockout Mice. 61
30647818 2018
39
A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system. 61
29440889 2018
40
Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair. 61
30038551 2018
41
Stem Cells in Cartilage Diseases and Repair 2018. 61
30140290 2018
42
Investigating magnetic susceptibility of human knee joint at 7 Tesla. 61
28097689 2017
43
Bone-strengthening pill (BSP) promotes bone cell and chondrocyte repair, and the clinical and experimental study of BSP in the treatment of osteonecrosis of the femoral head. 61
29228594 2017
44
PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies. 61
28317389 2017
45
Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI. 61
28727417 2017
46
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. 61
28929469 2017
47
Advances in Application of Mechanical Stimuli in Bioreactors for Cartilage Tissue Engineering. 61
28463576 2017
48
Regulation of Cartilage Development and Diseases by Transcription Factors. 61
28955690 2017
49
Markers of Bone and Cartilage Turnover. 61
28444666 2017
50
Review: Interventions for Cartilage Disease: Current State-of-the-Art and Emerging Technologies. 61
28294573 2017

Variations for Cartilage Disease

Expression for Cartilage Disease

Search GEO for disease gene expression data for Cartilage Disease.

Pathways for Cartilage Disease

GO Terms for Cartilage Disease

Cellular components related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 MMP13 MATN1 IHH CRP COMP COL2A1
2 extracellular space GO:0005615 9.93 MMP13 MATN1 KRT86 IHH CRP COMP
3 collagen-containing extracellular matrix GO:0062023 9.56 MATN1 COMP COL2A1 COL10A1 ADAMTS5 ADAMTS4
4 collagen trimer GO:0005581 9.5 MMP13 COL2A1 COL10A1
5 extracellular matrix GO:0031012 9.28 MMP13 MATN1 IHH COMP COL2A1 COL10A1

Biological processes related to Cartilage Disease according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 10.07 MMP13 IHH ADAMTS5 ADAMTS4 ADAMTS3 ACAN
2 negative regulation of transcription, DNA-templated GO:0045892 10.06 SOX9 SOX6 SOX5 RUNX2 BMP2
3 regulation of gene expression GO:0010468 9.95 SOX9 SOX6 RUNX2 IHH COMP COL2A1
4 in utero embryonic development GO:0001701 9.93 SOX6 IHH BMP2 ADAMTS3
5 osteoblast differentiation GO:0001649 9.84 RUNX2 IHH BMP2
6 cell fate commitment GO:0045165 9.84 SOX9 SOX6 SOX5 BMP2
7 BMP signaling pathway GO:0030509 9.83 RUNX2 COMP BMP2
8 collagen fibril organization GO:0030199 9.83 COMP COL2A1 ADAMTS3 ACAN
9 chondrocyte differentiation GO:0002062 9.8 SOX9 RUNX2 COL2A1 BMP2
10 extracellular matrix organization GO:0030198 9.8 SOX9 MMP13 MATN1 COMP COL2A1 COL10A1
11 extracellular matrix disassembly GO:0022617 9.79 MMP13 ADAMTS5 ADAMTS4
12 cellular response to transforming growth factor beta stimulus GO:0071560 9.79 SOX9 SOX6 SOX5
13 cellular response to BMP stimulus GO:0071773 9.76 SOX9 RUNX2 COL2A1 BMP2
14 bone mineralization GO:0030282 9.75 MMP13 COMP BMP2
15 endochondral ossification GO:0001958 9.73 RUNX2 MMP13 COL2A1
16 cartilage condensation GO:0001502 9.72 SOX9 COL2A1 ACAN
17 positive regulation of chondrocyte differentiation GO:0032332 9.71 SOX9 SOX6 SOX5 RUNX2
18 proteoglycan metabolic process GO:0006029 9.69 IHH COL2A1 BMP2
19 endocardial cushion morphogenesis GO:0003203 9.67 SOX9 BMP2
20 chondrocyte development GO:0002063 9.67 SOX9 RUNX2 COMP ACAN
21 chondrocyte proliferation GO:0035988 9.65 IHH COMP
22 limb bud formation GO:0060174 9.65 SOX9 COL2A1
23 growth plate cartilage development GO:0003417 9.64 MMP13 COMP
24 notochord development GO:0030903 9.64 SOX9 COL2A1
25 negative regulation of cardiac muscle cell differentiation GO:2000726 9.63 SOX6 BMP2
26 ossification GO:0001503 9.63 SOX9 RUNX2 IHH COMP COL2A1 BMP2
27 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.62 RUNX2 BMP2
28 positive regulation of cartilage development GO:0061036 9.62 SOX9 SOX6 SOX5 BMP2
29 otic vesicle development GO:0071599 9.61 SOX9 COL2A1
30 positive regulation of mesenchymal stem cell differentiation GO:2000741 9.61 SOX9 SOX6 SOX5
31 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.6 RUNX2 BMP2
32 anterior head development GO:0097065 9.58 SOX9 COL2A1
33 chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003413 9.57 SOX9 IHH
34 cartilage development GO:0051216 9.5 SOX9 SOX6 MMP13 IHH COMP COL2A1
35 skeletal system development GO:0001501 9.28 SOX9 RUNX2 IHH COMP COL2A1 COL10A1

Molecular functions related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 TNFRSF10A SOX9 SOX6 SOX5 RUNX2 RPL34
2 calcium ion binding GO:0005509 9.8 MMP13 MATN1 IHH CRP COMP ACAN
3 peptidase activity GO:0008233 9.77 MMP13 IHH ADAMTS5 ADAMTS4 ADAMTS3
4 protease binding GO:0002020 9.61 TNFRSF10A COMP ADAMTS4
5 metallopeptidase activity GO:0008237 9.46 MMP13 ADAMTS5 ADAMTS4 ADAMTS3
6 proteoglycan binding GO:0043394 9.4 COMP COL2A1
7 metalloendopeptidase activity GO:0004222 9.26 MMP13 ADAMTS5 ADAMTS4 ADAMTS3
8 extracellular matrix structural constituent GO:0005201 9.02 MATN1 COMP COL2A1 COL10A1 ACAN

Sources for Cartilage Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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