MCID: CRT017
MIFTS: 54

Cartilage Disease

Categories: Bone diseases, Ear diseases, Smell/Taste diseases

Aliases & Classifications for Cartilage Disease

MalaCards integrated aliases for Cartilage Disease:

Name: Cartilage Disease 12 15 37 17
Cartilage Diseases 54 43 71
Cartilage Disorders 42
Cartilage Disorder 12
Chondropathy 12
Cartilage 17

Classifications:



External Ids:

Disease Ontology 12 DOID:1222
MeSH 43 D002357
SNOMED-CT 67 50927007
UMLS 71 C0007302

Summaries for Cartilage Disease

MedlinePlus : 42 Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. It also gives shape and support to other parts of your body, such as your ears, nose and windpipe. Healthy cartilage helps you move by allowing your bones to glide over each other. It also protects bones by preventing them from rubbing against each other. Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. It can also lead to joint damage and deformity. Causes of cartilage problems include Tears and injuries, such as sports injuries Genetic factors Other disorders, such as some types of arthritis Osteoarthritis results from breakdown of cartilage. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Cartilage Disease, also known as cartilage diseases, is related to enchondromatosis, multiple, ollier type and multiple epiphyseal dysplasia, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Cartilage Disease is COL10A1 (Collagen Type X Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Degradation of the extracellular matrix. The drugs Simvastatin and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 74 Cartilage is a resilient and smooth elastic tissue, a rubber-like padding that covers and protects the... more...

Related Diseases for Cartilage Disease

Diseases related to Cartilage Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1194)
# Related Disease Score Top Affiliating Genes
1 enchondromatosis, multiple, ollier type 33.0 RUNX2 MMP13 COL2A1 ACAN
2 multiple epiphyseal dysplasia 33.0 SOX9 COMP COL2A1 ACAN
3 achondroplasia 32.9 SOX9 COMP COL2A1 ACAN
4 achondrogenesis 32.6 MATN1 COMP COL2A1 COL10A1 ACAN
5 spondyloepiphyseal dysplasia with congenital joint dislocations 32.6 COMP COL2A1 ACAN
6 fibrochondrogenesis 32.6 SOX9 COL2A1 ACAN
7 tracheal disease 32.6 SOX9 CRP COL2A1
8 otospondylomegaepiphyseal dysplasia, autosomal recessive 32.6 COMP COL2A1 COL10A1
9 synovial chondromatosis 32.6 SOX9 RUNX2 COL2A1
10 skeletal dysplasias 32.6 COMP COL2A1
11 kashin-beck disease 32.5 TNF IL1B COL2A1
12 systemic onset juvenile idiopathic arthritis 32.5 TNF IL1B
13 platyspondylic lethal skeletal dysplasia, torrance type 32.3 COMP COL2A1 COL10A1
14 rheumatoid arthritis 32.3 TNF MMP13 IL1B CRP COMP COL2A1
15 nose disease 31.8 TNF IL1B CRP
16 connective tissue disease 31.7 TNF RUNX2 MMP13 IL1B CRP COL2A1
17 campomelic dysplasia 31.7 SOX9 SOX6 SOX5 MATN1 COL2A1 COL10A1
18 odontochondrodysplasia 31.4 SOX9 SOX6 SOX5 RUNX2 MMP13 MATN1
19 bone development disease 31.4 SOX9 RUNX2 COMP COL2A1 COL10A1 ACAN
20 pseudoachondroplasia 31.3 MATN1 COMP COL2A1 ACAN
21 chondromalacia 31.3 TNFRSF10A TNF MATN1 CRP COMP ACAN
22 alcoholic hepatitis 31.2 TNF IL1B CRP
23 ankylosis 31.0 TNF RUNX2 CRP
24 septic arthritis 31.0 TNF IL1B CRP
25 bronchial disease 30.9 TNF IL1B CRP
26 arthropathy 30.9 TNF MMP13 IL1B CRP COMP COL2A1
27 proteasome-associated autoinflammatory syndrome 1 30.9 TNF IL1B CRP
28 metaphyseal dysplasia 30.7 RUNX2 MMP13 COL2A1 COL10A1
29 coxa vara 30.7 MMP13 COL2A1 COL10A1
30 spondyloepiphyseal dysplasia congenita 30.7 COMP COL2A1 COL10A1
31 hypochondrogenesis 30.7 MATN1 COL2A1 ACAN
32 achondrogenesis, type ii 30.6 MATN1 COMP COL2A1
33 osteochondrosis 30.6 SOX9 COL2A1 ACAN
34 psoriatic arthritis 30.5 TNF IL1B CRP COMP
35 reactive arthritis 30.5 TNF IL1B CRP COMP
36 erysipelas 30.4 TNF IL1B CRP
37 middle ear disease 30.4 TNF IL1B CRP
38 pharyngitis 30.2 TNF IL1B CRP
39 tendinitis 30.2 TNF MMP13 IL1B CRP COMP
40 spinal stenosis 30.2 RPL34 MMP13 COL2A1 ACAN
41 brittle bone disorder 30.2 SOX9 RUNX2 COL2A1 ADAMTS4 ACAN
42 exostosis 30.2 MMP13 COL2A1 ACAN
43 relapsing polychondritis 30.1 MATN1 CRP COMP
44 bronchiectasis 30.1 TNF IL1B CRP
45 myeloma, multiple 30.1 TNFRSF10A TNF RUNX2 IL1B CRP
46 pericarditis 30.1 TNF IL1B CRP
47 spondylolisthesis 30.0 RPL34 CRP ACAN
48 lyme disease 30.0 TNF IL1B CRP
49 brachydactyly 30.0 RUNX2 COMP COL2A1 ACAN
50 degenerative disc disease 30.0 SOX9 RPL34 MMP13 ADAMTS5 ADAMTS4 ADAMTS3

Graphical network of the top 20 diseases related to Cartilage Disease:



Diseases related to Cartilage Disease

Symptoms & Phenotypes for Cartilage Disease

UMLS symptoms related to Cartilage Disease:


back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Cartilage Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ADAMTS3 COL2A1 COMP CRP IL1B MMP13
2 growth/size/body region MP:0005378 10.03 ADAMTS3 ADAMTS4 COL10A1 COL2A1 COMP IL1B
3 craniofacial MP:0005382 9.97 ADAMTS3 COL10A1 COL2A1 IL1B RUNX2 SOX5
4 immune system MP:0005387 9.9 ADAMTS3 ADAMTS5 COL10A1 COL2A1 COMP CRP
5 limbs/digits/tail MP:0005371 9.65 ADAMTS5 COL10A1 COL2A1 COMP MMP13 RUNX2
6 skeleton MP:0005390 9.47 ADAMTS3 ADAMTS4 ADAMTS5 COL10A1 COL2A1 COMP

Drugs & Therapeutics for Cartilage Disease

Drugs for Cartilage Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 356)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Etanercept Approved, Investigational Phase 4 185243-69-0
3
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
4 Orange Approved Phase 4
5
Adalimumab Approved Phase 4 331731-18-1 16219006
6
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
7
Acetaminophen Approved Phase 4 103-90-2 1983
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
10
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
11
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
12 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
13
Ibuprofen Approved Phase 4 15687-27-1 3672
14
Zinc Approved, Investigational Phase 4 7440-66-6 32051
15
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
16
Liraglutide Approved Phase 4 204656-20-2 44147092
17
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
18
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
19
tannic acid Approved Phase 4 1401-55-4
20
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
21
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
22
Ifosfamide Approved Phase 4 3778-73-2 3690
23
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
24
Desflurane Approved Phase 4 57041-67-5 42113
25
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
26
Tranexamic Acid Approved Phase 4 1197-18-8 5526
27
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
28
Racepinephrine Approved Phase 4 329-65-7 838
29
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
30
Morphine Approved, Investigational Phase 4 57-27-2 5288826
31
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
32
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
33 Hypolipidemic Agents Phase 4
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
35 Lipid Regulating Agents Phase 4
36 Anticholesteremic Agents Phase 4
37 Ergocalciferols Phase 4
38 Vitamin D2 Phase 4
39 Analgesics, Non-Narcotic Phase 4
40 Cyclooxygenase Inhibitors Phase 4
41 Anti-Inflammatory Agents Phase 4
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4
43
protease inhibitors Phase 4
44 HIV Protease Inhibitors Phase 4
45 Antipyretics Phase 4
46
Chondroitin Phase 4 9007-27-6 53477707
47 Serine Proteinase Inhibitors Phase 4
48 Platelet Aggregation Inhibitors Phase 4
49
Rosmarinic acid Phase 4 537-15-5 5281792
50 Methylprednisolone Acetate Phase 4

Interventional clinical trials:

(show top 50) (show all 1122)
# Name Status NCT ID Phase Drugs
1 A Double-blind, Randomized, Post-marketing Surveillance to Evaluate the Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 A Single-Blind Prospective Parallel Control Group Pilot Study to Assess the Effect of Hylan G-F 20 (Synvisc) Supplementation on Cartilage Preservation in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
3 The Influence of Hyaluronic Acid Injection Following Knee Arthroscopy Unknown status NCT02640144 Phase 4 Sodium Hyaluronate 1%;Placebo
4 Random Clinical Trial for Comparison of Efficacy and Safety of Simple Microfracture and Modified Microfracture Using Collagen in the Patients With Knee Cartilage Defects Unknown status NCT02539030 Phase 4
5 This Clinical Trial Evaluated the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Patients With Cartilage Defects in Their Ankles. Unknown status NCT02519881 Phase 4
6 A Post-marketing Surveillance to Evaluate the Efficacy and Safety of CHONDRON (Autologous Cultured Chondrocyte) Through Arthroscopy in Patients With Knee Cartilage Defects Unknown status NCT02539069 Phase 4
7 This Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) in Patients With Cartilage Defects in Their Knees. Unknown status NCT02539056 Phase 4
8 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
9 Intra-Articular Injections of Hyaluronan Versus 20 Ml NaCl Versus Placebo in Treatment of Knee Osteoarthritis: a Randomised, Double-Blind, Placebo Controlled Single Centre Trial. Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
10 A Randomized, Double-blind Study to Evaluate the Efficacy of Iguratimod Versus Placebo in Patients With Rheumatoid Arthritis on Magnetic Resonance Imaging (MRI) Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
11 Validation of a Device for Performing Valgus and Varus Stress X-rays of the Knee Unknown status NCT02444663 Phase 4
12 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN: a Pilot Study Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
13 The Effects of Simvastatin in Patients With Chronic Obstructive Pulmonary Disease Unknown status NCT00680641 Phase 4 Simvastatin;Placebo
14 The Assessment of the Effect of Vitamin D Supplementation on the Serum of AGES and Endothelialy Factors and Gene Expression of Glyoxalase Enzyme and YKL-40 Factor in PBMC Cells in the Patients With Type 2 Diabetes . Unknown status NCT03008057 Phase 4
15 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
16 A Prospective, Multi-Center, Randomized, Single-Blind, Controlled Study Comparing the Trufit CB (Cartilage Bone) Implant to Microfracture for the Treatment of Patients With Single, Isolated Defects of the Knee Completed NCT01246635 Phase 4
17 Platelet-rich Plasma (PRP) vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology: a Randomized Double-blind Controlled Trial Completed NCT01670578 Phase 4
18 Early Post-op. Viscosupplementation After Primary Anterior Cruciate Ligament (ACL) Reconstruction: a Randomized, Placebo Controlled Trial Completed NCT02630407 Phase 4
19 Quantifications of Biochemical Changes of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection Using Novel MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) Techniques Completed NCT01895959 Phase 4 Euflexxa
20 A Prospective, Longitudinal Within-Patient Evaluation of the Effectiveness (Durability) of Carticel® (Autologous Cultured Chondrocytes) Compared to Non-Carticel Surgical Treatment for Articular Cartilage Defects of the Knee. Completed NCT00158613 Phase 4
21 A Randomized, Double Blinded, Parallel Group, Placebo-controlled Clinical Trial to Assess the Protective Effect of JOINS on Cartilage in Knee Osteoarthritis Completed NCT01293955 Phase 4 JOINS 200mg;Placebo
22 Double Blind, Randomized, Multicentre, Placebo Controlled Study to Assess the Efficacy and Safety of Reflex Plus™ in Osteoarthritis Completed NCT02655939 Phase 4
23 Phase 4 Study of Diacerein as Adjuvant to Diclofenac Sodium in Indian Patients of OA Knee Completed NCT01120015 Phase 4 diacerein
24 Adalimumab in Axial Spondyloarthritis. An Investigation of Whole-body MRI, MRI of Sacroiliac Joints and Spine and Soluble Biomarkers of Joint Inflammation and Damage. Completed NCT01029847 Phase 4 Adalimumab;Placebo
25 Efficacy and Safety of the Infiltration of Autologous Plasma Rich in Growth Factors (PRGF) in the Symptomatic Treatment of Knee Osteoarthritis Completed NCT00782197 Phase 4
26 Efficacy of Bone Marrow Aspirate Concentrate Compared With Platelet Rich Plasma for the Treatment of Symptomatic Knee Osteoarthritis: A Randomized, Controlled Clinical Trial Completed NCT03289416 Phase 4
27 Human Clinical Trial to Investigate the Effects of High Rosmarinic Acid Spearmint Tea on Markers of Pain, Physical Function and Disease Activity in Osteoarthritis of the Knee Completed NCT01380015 Phase 4
28 Effect of Intra-articular Steroids on Structural Progression of Knee OA: A Randomized Controlled Trial Completed NCT01230424 Phase 4 Triamcinolone Acetonide;0.9% Sodium Chloride Injection as Placebo
29 Does Anesthetic Contribute to Symptomatic Relief in Corticosteroid Injections for Knee Osteoarthritis? A Double-Blind Randomized Trial Comparing Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections Completed NCT02576249 Phase 4 Ropivacaine;Normal saline;Methylprednisolone
30 Phase 4 Study of Glucosamine Sulphate in the Treatment for Chronic Low Back Pain Patients With Degenerative Lumbar MRI Findings Completed NCT00404079 Phase 4 Glucosamine sulphate;Placebo
31 Single Center, Randomized, Double-Blind, Placebo-Controlled Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab Completed NCT01144143 Phase 4 Infliximab;Placebo;Standard of Care: Methylprednisolone acetate
32 Effect of Interventions on Progression of Knee Osteoarthritis - a Comparison of Effect of Glucosamine/Chondroitin or Diacerin Vs Placebo: Measured by Clinical, Radiological and Biochemical Parameters Completed NCT02178137 Phase 4 Diacerien;Glucosamine/Chondroitin;Placebo
33 Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis Following Liraglutide Treatment, Investigating the Impact on Inflammation Completed NCT02928679 Phase 4 Liraglutide 3 mg (Saxenda);Liraglutide 3 mg placebo
34 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
35 The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial Completed NCT03825133 Phase 4 Hyaluronic Acid
36 Spa Therapy in Knee Osteoarthritis: Study on Cost/Effectiveness - Cost/Utility and Possible Mechanisms of Action Completed NCT01538043 Phase 4
37 Acute Effect of Resistance Training in Inflammatory Markers in Women With Rheumatoid Arthritis Completed NCT02401958 Phase 4
38 The Effect of Alfentanil on the Lower Esophageal Sphincter During Anesthesia Induction - a Study in Volunteers Completed NCT01199458 Phase 4 alfentanil;saline
39 Proximal Tibial Open Wedge Osteotomy. Stability and Healing Evaluated in a Clinical Prospective, Randomized Trial Using RSA. Completed NCT00319280 Phase 4
40 Efficacy and Safety of Intra-Articular Injections of Durolane® in the Treatment of Osteoarthritis in the Knee Completed NCT00731289 Phase 4 hyaluronic acid;triamcinolone
41 Ultrasound Guidance or Electrical Nerve Stimulation for Interscalene Brachial Plexus Block: a Randomized, Controlled Trial Completed NCT00702416 Phase 4 Ropivacaine;Paracetamol;Morphine;Fentanyl
42 Best Effect of Viscosupplementation With Hyaluronic Acid and Triamcinolone in Patients With Knee Osteoarthritis. Prospective Randomized Study Between Two Different Applications Regimens Completed NCT01824485 Phase 4 viscosupplementation 1+1+1;viscosupplementation 3 at once
43 Multicenter Randomized Controlled Trial for the Treatment of Knee Chondral and Osteochondral Lesions: Marrow Stimulation Techniques vs MaioRegen Completed NCT01282034 Phase 4
44 Patterned Electrical Neuromuscular Stimulation and Therapeutic Exercise for Osteoarthritis of the Knee: Pilot Study Completed NCT00701506 Phase 4
45 Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome Completed NCT03586154 Phase 4 ketamine and bupivacaine injection
46 The Efficacy of Demineralized Bone Matrix and Autogenous Bone Graft in Accelerated Fracture Healing in Closed Tibia Fracture Completed NCT00299052 Phase 4
47 Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section. A Double Blind, Randomized, Placebo Controlled Trial. Completed NCT03068260 Phase 4 Ropivacaine;Saline;Acetaminophen;Ibuprofen 400Mg Tablet / Celebra 100 Mg tablet;Morphine
48 Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule Recruiting NCT04223583 Phase 4 Anlotinib Hydrochloride
49 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of 12 Months Subcutaneous Tocilizumab in Rheumatoid Arthritis Phase IV Prospective Multicentrique Study Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
50 Leukocyte-rich PRP vs Leukocyte-poor PRP for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial Recruiting NCT02923700 Phase 4

Search NIH Clinical Center for Cartilage Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


CHONDROITIN SODIUM
Chondroitin Sulfates

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Cartilage Disease cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: cartilage diseases

Genetic Tests for Cartilage Disease

Anatomical Context for Cartilage Disease

MalaCards organs/tissues related to Cartilage Disease:

40
Bone, Bone Marrow, Testes, Skin, Thyroid, Brain, Eye

Publications for Cartilage Disease

Articles related to Cartilage Disease:

(show top 50) (show all 294)
# Title Authors PMID Year
1
Supraglottoplasty in Neonates under One Month of Age. 42
31875410 2020
2
Focal metallic inlay resurfacing prosthesis in articular cartilage defects: short-term results of 118 patients and 2 different implants. 42
31748883 2020
3
Which Is More Effective for Minimally Invasive Pectus Repair: Epidural or Paravertebral Block? 42
31742471 2020
4
Cartilage tissue and therapeutic strategies for cartilage repair. 61
32520688 2020
5
Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the "kidney governing bone" theory. 61
32295616 2020
6
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis. 61
32200258 2020
7
Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF-κB signaling pathway inhibition. 61
32112120 2020
8
Ganglioside GM3 Up-Regulate Chondrogenic Differentiation by Transform Growth Factor Receptors. 61
32183071 2020
9
Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes. 61
31918067 2020
10
Platelet rich plasma for treatment of osteochondral lesions of the talus: A systematic review of clinical trials. 61
32071508 2020
11
Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair. 61
31789105 2020
12
Identification and expression analysis of microRNAs in tibial growth plate of chicken through thiram toxicity. 61
31873907 2020
13
Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis. 61
32092942 2020
14
Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats. 61
32211385 2020
15
DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions. 61
31980739 2020
16
Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy. 61
32117924 2020
17
[Correlation between histone methylation level and pathological development of osteoarthritis]. 61
31955544 2019
18
Yam-Containing Serum Promotes Proliferation and Chondrogenic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells and Synthesis of Glycosaminoglycan. 61
31722364 2019
19
Defective WNT signaling may protect from articular cartilage deterioration - a quantitative MRI study on subjects with a heterozygous WNT1 mutation. 61
31299386 2019
20
Glutamic acid-based dendritic peptides for scaffold-free cartilage tissue engineering. 61
31521812 2019
21
Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies. 61
31455417 2019
22
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases. 61
31220958 2019
23
ADAM8 promotes chondrosarcoma cell migration and invasion by activating the NF-κB/MMP-13 signaling axis. 61
31305294 2019
24
Intra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair. 61
30954618 2019
25
Role of Epigenomics in Bone and Cartilage Disease. 61
30715766 2019
26
Ligustrazine recovers thiram-induced tibial dyschondroplasia in chickens: Involvement of new molecules modulating integrin beta 3. 61
30388538 2019
27
Osteoarthritis as an organ disease: from the cradle to the grave. 61
30698270 2019
28
The Clinical Evidence Behind Biologic Therapies Promoted at Annual Orthopaedic Meetings: A Systematic Review. 61
30455088 2019
29
Novel Hybrid Gels Made of High and Low Molecular Weight Hyaluronic Acid Induce Proliferation and Reduce Inflammation in an Osteoarthritis In Vitro Model Based on Human Synoviocytes and Chondrocytes. 61
31179322 2019
30
4-Phenylbutyric Acid Reduces Endoplasmic Reticulum Stress in Chondrocytes That Is Caused by Loss of the Protein Disulfide Isomerase ERp57. 61
31781343 2019
31
Proteomic Identification and Time-Course Monitoring of Secreted Proteins During Expansion of Human Mesenchymal Stem/Stromal in Stirred-Tank Bioreactor. 61
31297369 2019
32
Pre-Clinical Translation of Second Harmonic Microscopy of Meniscal and Articular Cartilage Using a Prototype Nonlinear Microendoscope. 61
30701146 2019
33
Arthroscopic Hip Joint Assessment can Impact the Indications for PAO Surgery. 61
31413688 2019
34
Treatment of Articular Cartilage Defects: Focus on Tissue Engineering. 61
30348681 2018
35
Articular Cartilage Injuries of the Knee: Patient Health Literacy, Expectations for Management, and Clinical Outcomes. 61
30486654 2018
36
Cartilage diseases. 61
29803938 2018
37
On incorporating osmotic prestretch/prestress in image-driven finite element simulations of cartilage. 61
30031245 2018
38
Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors. 61
29726060 2018
39
Human Engineered Cartilage and Decellularized Matrix as an Alternative to Animal Osteoarthritis Model. 61
30960663 2018
40
Curcumin protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in vitro. 61
29604245 2018
41
Adiponectin Downregulates TNF-α Expression in Degenerated Intervertebral Discs. 61
28767622 2018
42
Radiographic, computed tomographic, and arthroscopic diagnosis of radioulnar incongruence in dogs with medial coronoid disease. 61
29536555 2018
43
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics. 61
28827187 2018
44
Ghrelin protects against osteoarthritis through interplay with Akt and NF-κB signaling pathways. 61
29070587 2018
45
miR-27b promotes type II collagen expression by targetting peroxisome proliferator-activated receptor-γ2 during rat articular chondrocyte differentiation. 61
29187585 2018
46
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development. 61
29402405 2018
47
A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system. 61
29440889 2018
48
Different Forms of ER Stress in Chondrocytes Result in Short Stature Disorders and Degenerative Cartilage Diseases: New Insights by Cartilage-Specific ERp57 Knockout Mice. 61
30647818 2018
49
Stem Cells in Cartilage Diseases and Repair 2018. 61
30140290 2018
50
Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair. 61
30038551 2018

Variations for Cartilage Disease

Expression for Cartilage Disease

Search GEO for disease gene expression data for Cartilage Disease.

Pathways for Cartilage Disease

GO Terms for Cartilage Disease

Cellular components related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 TNF MMP13 MATN1 IL1B CRP COMP
2 extracellular space GO:0005615 9.93 TNF MMP13 MATN1 KRT86 IL1B CRP
3 collagen-containing extracellular matrix GO:0062023 9.56 MATN1 COMP COL2A1 COL10A1 ADAMTS5 ADAMTS4
4 collagen trimer GO:0005581 9.5 MMP13 COL2A1 COL10A1
5 extracellular matrix GO:0031012 9.28 MMP13 MATN1 COMP COL2A1 COL10A1 ADAMTS5

Biological processes related to Cartilage Disease according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.04 TNF SOX9 RUNX2 IL1B CRP
2 regulation of gene expression GO:0010468 9.98 SOX9 SOX6 RUNX2 COMP COL2A1
3 central nervous system development GO:0007417 9.88 SOX9 SOX6 COL2A1 ACAN
4 cellular response to mechanical stimulus GO:0071260 9.83 TNFRSF10A SOX9 IL1B
5 cell fate commitment GO:0045165 9.81 SOX9 SOX6 SOX5
6 ossification GO:0001503 9.8 SOX9 RUNX2 COMP COL2A1
7 cartilage development GO:0051216 9.8 SOX9 SOX6 SOX5 MMP13 COMP COL2A1
8 skeletal system development GO:0001501 9.8 SOX9 RUNX2 COMP COL2A1 COL10A1 ADAMTS4
9 extracellular matrix disassembly GO:0022617 9.79 MMP13 ADAMTS5 ADAMTS4
10 cellular response to transforming growth factor beta stimulus GO:0071560 9.79 SOX9 SOX6 SOX5
11 collagen fibril organization GO:0030199 9.76 COMP COL2A1 ADAMTS3 ACAN
12 protein kinase B signaling GO:0043491 9.73 TNF SOX9 IL1B
13 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.72 TNF IL1B COL2A1
14 cellular response to BMP stimulus GO:0071773 9.71 SOX9 RUNX2 COL2A1
15 chondrocyte development GO:0002063 9.71 SOX9 RUNX2 COMP ACAN
16 endochondral ossification GO:0001958 9.69 RUNX2 MMP13 COL2A1
17 positive regulation of chemokine biosynthetic process GO:0045080 9.67 TNF IL1B
18 positive regulation of chondrocyte differentiation GO:0032332 9.67 SOX9 SOX6 SOX5 RUNX2
19 positive regulation of neuroinflammatory response GO:0150078 9.66 TNF IL1B
20 limb bud formation GO:0060174 9.66 SOX9 COL2A1
21 notochord development GO:0030903 9.65 SOX9 COL2A1
22 positive regulation of cartilage development GO:0061036 9.65 SOX9 SOX6 SOX5
23 negative regulation of lipid storage GO:0010888 9.64 TNF CRP
24 growth plate cartilage development GO:0003417 9.64 MMP13 COMP
25 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
26 otic vesicle development GO:0071599 9.62 SOX9 COL2A1
27 positive regulation of chondrocyte proliferation GO:1902732 9.61 SOX9 COMP
28 positive regulation of mesenchymal stem cell differentiation GO:2000741 9.61 SOX9 SOX6 SOX5
29 anterior head development GO:0097065 9.6 SOX9 COL2A1
30 positive regulation of fever generation GO:0031622 9.59 TNF IL1B
31 sequestering of triglyceride GO:0030730 9.57 TNF IL1B
32 cartilage condensation GO:0001502 9.55 SOX9 SOX6 SOX5 COL2A1 ACAN
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IL1B
34 chondrocyte differentiation GO:0002062 9.43 SOX9 SOX6 SOX5 RUNX2 MATN1 COL2A1
35 extracellular matrix organization GO:0030198 9.36 TNF SOX9 MMP13 MATN1 COMP COL2A1

Molecular functions related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 TNFRSF10A TNF SOX9 SOX6 SOX5 RUNX2
2 transcription regulatory region DNA binding GO:0044212 9.67 TNF SOX9 SOX6 RUNX2
3 metallopeptidase activity GO:0008237 9.56 MMP13 ADAMTS5 ADAMTS4 ADAMTS3
4 metalloendopeptidase activity GO:0004222 9.46 MMP13 ADAMTS5 ADAMTS4 ADAMTS3
5 protease binding GO:0002020 9.26 TNFRSF10A TNF COMP ADAMTS4
6 extracellular matrix structural constituent GO:0005201 9.02 MATN1 COMP COL2A1 COL10A1 ACAN

Sources for Cartilage Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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