MCID: CRT017
MIFTS: 54

Cartilage Disease

Categories: Bone diseases, Ear diseases, Smell/Taste diseases

Aliases & Classifications for Cartilage Disease

MalaCards integrated aliases for Cartilage Disease:

Name: Cartilage Disease 12 15 38 17
Cartilage Diseases 55 44 72
Cartilage Disorders 43
Cartilage Disorder 12
Chondropathy 12
Cartilage 17

Classifications:



External Ids:

Disease Ontology 12 DOID:1222
MeSH 44 D002357
SNOMED-CT 68 50927007
UMLS 72 C0007302

Summaries for Cartilage Disease

MedlinePlus : 43 Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. It also gives shape and support to other parts of your body, such as your ears, nose and windpipe. Healthy cartilage helps you move by allowing your bones to glide over each other. It also protects bones by preventing them from rubbing against each other. Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. It can also lead to joint damage and deformity. Causes of cartilage problems include Tears and injuries, such as sports injuries Genetic factors Other disorders, such as some types of arthritis Osteoarthritis results from breakdown of cartilage. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Cartilage Disease, also known as cartilage diseases, is related to enchondromatosis, multiple, ollier type and kniest dysplasia, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Cartilage Disease is COL10A1 (Collagen Type X Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Degradation of the extracellular matrix. The drugs Simvastatin and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 75 Cartilage is a resilient and smooth elastic tissue, a rubber-like padding that covers and protects the... more...

Related Diseases for Cartilage Disease

Diseases related to Cartilage Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1103)
# Related Disease Score Top Affiliating Genes
1 enchondromatosis, multiple, ollier type 32.9 IHH ACAN
2 kniest dysplasia 32.8 COMP COL2A1
3 multiple epiphyseal dysplasia 32.7 COMP COL2A1 ACAN
4 synovial chondromatosis 32.7 SOX9 COL2A1
5 spondyloepiphyseal dysplasia with congenital joint dislocations 32.7 COL2A1 ACAN
6 skeletal dysplasias 32.6 COMP COL2A1
7 achondroplasia 32.6 SOX9 COMP ACAN
8 achondrogenesis, type ia 32.5 COL2A1 ACAN
9 campomelic dysplasia 32.2 SOX9 SOX5 COL2A1
10 chondromyxoid fibroma 31.9 SOX9 COL10A1
11 arthropathy 31.4 CRP COMP ACAN
12 chondromalacia 31.3 TNFRSF10A IL1RN COMP
13 arthritis 31.2 IL1RN COL2A1 ACAN
14 degenerative disc disease 31.1 SOX9 ACAN
15 pyle disease 31.1 COL2A1 COL10A1
16 bone development disease 31.0 SOX9 IHH COMP COL2A1
17 pseudoachondroplasia 31.0 COMP ACAN
18 coxa vara 30.8 COL2A1 COL10A1
19 bone disease 30.8 COL2A1 COL10A1 ACAN
20 tendinitis 30.7 CRP COMP
21 epiphyseal dysplasia, multiple, 1 30.7 COMP ACAN
22 spondyloepimetaphyseal dysplasia, strudwick type 30.6 COL2A1 COL10A1
23 metaphyseal chondrodysplasia, schmid type 30.4 COMP COL10A1
24 tenosynovitis 30.3 CRP COMP
25 reactive arthritis 30.3 CRP COMP
26 spinal stenosis 30.2 COL2A1 ACAN
27 hypochondrogenesis 30.1 COMP COL2A1 ACAN
28 osteochondritis dissecans 30.1 COMP ACAN
29 achondrogenesis, type ii 30.1 COMP COL2A1 ACAN
30 diastrophic dysplasia 30.1 COMP COL2A1
31 relapsing polychondritis 30.0 CRP COMP
32 osteoarthritis 30.0 SOX9 COMP COL2A1 ACAN
33 brachydactyly 29.9 IHH COMP COL2A1
34 exanthem 29.7 IL1RN CRP
35 spondyloepiphyseal dysplasia congenita 29.7 IHH COMP COL2A1 COL10A1
36 pericarditis 29.6 IL1RN CRP
37 transient arthritis 29.5 TNFRSF10A COMP ACAN
38 synovitis 29.3 IL1RN CRP COMP
39 brucellosis 29.1 IL1RN CRP
40 bone inflammation disease 28.2 TNFRSF10A SOX9 IL1RN CRP COMP COL2A1
41 cartilage-hair hypoplasia 12.8
42 laryngeal cartilage cancer 12.4
43 cartilage-hair hypoplasia - anauxetic dysplasia spectrum disorders 12.4
44 ossified ear cartilages 12.4
45 cartilage cancer 12.3
46 keutel syndrome 12.1
47 metaphyseal dysplasia without hypotrichosis 12.1
48 rheumatoid arthritis 12.0
49 odontochondrodysplasia 12.0
50 magic syndrome 12.0

Graphical network of the top 20 diseases related to Cartilage Disease:



Diseases related to Cartilage Disease

Symptoms & Phenotypes for Cartilage Disease

UMLS symptoms related to Cartilage Disease:


back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Cartilage Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 COL2A1 COMP CRP IHH IL1RN SOX5
2 growth/size/body region MP:0005378 9.76 COL10A1 COL2A1 COMP IHH IL1RN SOX5
3 craniofacial MP:0005382 9.73 COL10A1 COL2A1 IHH SOX5 SOX6 SOX9
4 limbs/digits/tail MP:0005371 9.5 COL10A1 COL2A1 COMP IHH SOX5 SOX6
5 skeleton MP:0005390 9.23 COL10A1 COL2A1 COMP IHH IL1RN SOX5

Drugs & Therapeutics for Cartilage Disease

Drugs for Cartilage Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 387)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Etanercept Approved, Investigational Phase 4 185243-69-0
3
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
4
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
5 Orange Approved Phase 4
6
Adalimumab Approved Phase 4 331731-18-1 16219006
7
Acetaminophen Approved Phase 4 103-90-2 1983
8
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
9
Ibuprofen Approved Phase 4 15687-27-1 3672
10
Liraglutide Approved Phase 4 204656-20-2 44147092
11
Zinc Approved, Investigational Phase 4 7440-66-6 32051
12
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
13
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
14
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
15
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
16
Tranexamic Acid Approved Phase 4 1197-18-8 5526
17
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
18
Morphine Approved, Investigational Phase 4 57-27-2 5288826
19
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
20
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
21
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
22 Deslorelin Investigational, Vet_approved Phase 4 57773-65-6
23 Vaccines Phase 4
24 Lipid Regulating Agents Phase 4
25 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
26 Hypolipidemic Agents Phase 4
27 Anticholesteremic Agents Phase 4
28 Plasminogen Activator Inhibitor 1 Phase 4
29 Anesthetics Phase 4
30 Anti-Inflammatory Agents Phase 4
31 Analgesics, Non-Narcotic Phase 4
32 Cyclooxygenase Inhibitors Phase 4
33 Anti-Inflammatory Agents, Non-Steroidal Phase 4
34 Anesthetics, Local Phase 4
35 Diacetylrhein Phase 4
36 Calcium, Dietary Phase 4
37 Factor VIII Phase 4
38
Chondroitin Phase 4 9007-27-6 53477707
39 Antipyretics Phase 4
40 Serine Proteinase Inhibitors Phase 4
41
Rosmarinic acid Phase 4 537-15-5 5281792
42 Platelet Aggregation Inhibitors Phase 4
43 Neurotransmitter Agents Phase 4
44 Incretins Phase 4
45 Hypoglycemic Agents Phase 4
46 Astringents Phase 4
47 Anesthetics, Intravenous Phase 4
48 Anesthetics, General Phase 4
49 Adjuvants, Anesthesia Phase 4
50 Excitatory Amino Acid Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 971)
# Name Status NCT ID Phase Drugs
1 Random Clinical Trial for Comparison of Efficacy and Safety of Simple Microfracture and Modified Microfracture Using Collagen in the Patients With Knee Cartilage Defects Unknown status NCT02539030 Phase 4
2 This Clinical Trial Evaluated the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Patients With Cartilage Defects in Their Ankles. Unknown status NCT02519881 Phase 4
3 A Double-blind, Randomized, Post-marketing Surveillance to Evaluate the Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
4 Immunodeficiency in Cartilage-hair Hypoplasia: Correlation With Pulmonary Disease, Infections and Malignancy Unknown status NCT02383797 Phase 4
5 A Single-Blind Prospective Parallel Control Group Pilot Study to Assess the Effect of Hylan G-F 20 (Synvisc) Supplementation on Cartilage Preservation in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
6 The Influence of Hyaluronic Acid Injection Following Knee Arthroscopy Unknown status NCT02640144 Phase 4 Sodium Hyaluronate 1%;Placebo
7 A Post-marketing Surveillance to Evaluate the Efficacy and Safety of CHONDRON (Autologous Cultured Chondrocyte) Through Arthroscopy in Patients With Knee Cartilage Defects Unknown status NCT02539069 Phase 4
8 This Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) in Patients With Cartilage Defects in Their Knees. Unknown status NCT02539056 Phase 4
9 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
10 Intra-Articular Injections of Hyaluronan Versus 20 Ml NaCl Versus Placebo in Treatment of Knee Osteoarthritis: a Randomised, Double-Blind, Placebo Controlled Single Centre Trial. Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
11 A Randomized, Double-blind Study to Evaluate the Efficacy of Iguratimod Versus Placebo in Patients With Rheumatoid Arthritis on Magnetic Resonance Imaging (MRI) Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
12 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN: a Pilot Study Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
13 Validation of a Device for Performing Valgus and Varus Stress X-rays of the Knee Unknown status NCT02444663 Phase 4
14 The Effects of Simvastatin in Patients With Chronic Obstructive Pulmonary Disease Unknown status NCT00680641 Phase 4 Simvastatin;Placebo
15 The Assessment of the Effect of Vitamin D Supplementation on the Serum of AGES and Endothelialy Factors and Gene Expression of Glyoxalase Enzyme and YKL-40 Factor in PBMC Cells in the Patients With Type 2 Diabetes . Unknown status NCT03008057 Phase 4
16 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
17 A Prospective, Multi-Center, Randomized, Single-Blind, Controlled Study Comparing the Trufit CB (Cartilage Bone) Implant to Microfracture for the Treatment of Patients With Single, Isolated Defects of the Knee Completed NCT01246635 Phase 4
18 Platelet-rich Plasma (PRP) vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology: a Randomized Double-blind Controlled Trial Completed NCT01670578 Phase 4
19 Early Post-op. Viscosupplementation After Primary Anterior Cruciate Ligament (ACL) Reconstruction: a Randomized, Placebo Controlled Trial Completed NCT02630407 Phase 4
20 Quantifications of Biochemical Changes of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection Using Novel MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) Techniques Completed NCT01895959 Phase 4 Euflexxa
21 A Randomized, Double Blinded, Parallel Group, Placebo-controlled Clinical Trial to Assess the Protective Effect of JOINS on Cartilage in Knee Osteoarthritis Completed NCT01293955 Phase 4 JOINS 200mg;Placebo
22 Double Blind, Randomized, Multicentre, Placebo Controlled Study to Assess the Efficacy and Safety of Reflex Plus™ in Osteoarthritis Completed NCT02655939 Phase 4
23 Phase 4 Study of Diacerein as Adjuvant to Diclofenac Sodium in Indian Patients of OA Knee Completed NCT01120015 Phase 4 diacerein
24 Adalimumab in Axial Spondyloarthritis. An Investigation of Whole-body MRI, MRI of Sacroiliac Joints and Spine and Soluble Biomarkers of Joint Inflammation and Damage. Completed NCT01029847 Phase 4 Adalimumab;Placebo
25 Efficacy and Safety of the Infiltration of Autologous Plasma Rich in Growth Factors (PRGF) in the Symptomatic Treatment of Knee Osteoarthritis Completed NCT00782197 Phase 4
26 Human Clinical Trial to Investigate the Effects of High Rosmarinic Acid Spearmint Tea on Markers of Pain, Physical Function and Disease Activity in Osteoarthritis of the Knee Completed NCT01380015 Phase 4
27 Effect of Intra-articular Steroids on Structural Progression of Knee OA: A Randomized Controlled Trial Completed NCT01230424 Phase 4 Triamcinolone Acetonide;0.9% Sodium Chloride Injection as Placebo
28 Phase 4 Study of Glucosamine Sulphate in the Treatment for Chronic Low Back Pain Patients With Degenerative Lumbar MRI Findings Completed NCT00404079 Phase 4 Glucosamine sulphate;Placebo
29 Single Center, Randomized, Double-Blind, Placebo-Controlled Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab Completed NCT01144143 Phase 4 Infliximab;Placebo;Standard of Care: Methylprednisolone acetate
30 Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis Following Liraglutide Treatment, Investigating the Impact on Inflammation Completed NCT02928679 Phase 4 Liraglutide 3 mg (Saxenda);Liraglutide 3 mg placebo
31 Effect of Interventions on Progression of Knee Osteoarthritis - a Comparison of Effect of Glucosamine/Chondroitin or Diacerin Vs Placebo: Measured by Clinical, Radiological and Biochemical Parameters Completed NCT02178137 Phase 4 Diacerien;Glucosamine/Chondroitin;Placebo
32 Does Anesthetic Contribute to Symptomatic Relief in Corticosteroid Injections for Knee Osteoarthritis? A Double-Blind Randomized Trial Comparing Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections Completed NCT02576249 Phase 4 Ropivacaine;Normal saline;Methylprednisolone
33 The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial Completed NCT03825133 Phase 4 Hyaluronic Acid
34 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
35 Spa Therapy in Knee Osteoarthritis: Study on Cost/Effectiveness - Cost/Utility and Possible Mechanisms of Action Completed NCT01538043 Phase 4
36 Efficacy and Safety of Intra-Articular Injections of Durolane® in the Treatment of Osteoarthritis in the Knee Completed NCT00731289 Phase 4 hyaluronic acid;triamcinolone
37 The Effect of Alfentanil on the Lower Esophageal Sphincter During Anesthesia Induction - a Study in Volunteers Completed NCT01199458 Phase 4 alfentanil;saline
38 Acute Effect of Resistance Training in Inflammatory Markers in Women With Rheumatoid Arthritis Completed NCT02401958 Phase 4
39 Proximal Tibial Open Wedge Osteotomy. Stability and Healing Evaluated in a Clinical Prospective, Randomized Trial Using RSA. Completed NCT00319280 Phase 4
40 Ultrasound Guidance or Electrical Nerve Stimulation for Interscalene Brachial Plexus Block: a Randomized, Controlled Trial Completed NCT00702416 Phase 4 Ropivacaine;Paracetamol;Morphine;Fentanyl
41 Best Effect of Viscosupplementation With Hyaluronic Acid and Triamcinolone in Patients With Knee Osteoarthritis. Prospective Randomized Study Between Two Different Applications Regimens Completed NCT01824485 Phase 4 viscosupplementation 1+1+1;viscosupplementation 3 at once
42 Patterned Electrical Neuromuscular Stimulation and Therapeutic Exercise for Osteoarthritis of the Knee: Pilot Study Completed NCT00701506 Phase 4
43 Multicenter Randomized Controlled Trial for the Treatment of Knee Chondral and Osteochondral Lesions: Marrow Stimulation Techniques vs MaioRegen Completed NCT01282034 Phase 4
44 Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome Completed NCT03586154 Phase 4 ketamine and bupivacaine injection
45 The Efficacy of Demineralized Bone Matrix and Autogenous Bone Graft in Accelerated Fracture Healing in Closed Tibia Fracture Completed NCT00299052 Phase 4
46 Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section. A Double Blind, Randomized, Placebo Controlled Trial. Completed NCT03068260 Phase 4 Ropivacaine;Saline;Acetaminophen;Ibuprofen 400Mg Tablet / Celebra 100 Mg tablet;Morphine
47 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of 12 Months Subcutaneous Tocilizumab in Rheumatoid Arthritis Phase IV Prospective Multicentrique Study Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
48 Clinical Outcomes Following Randomization of Steroid Concentration in Patients With Glenohumeral Osteoarthritis Recruiting NCT03586687 Phase 4 Triamcinolone
49 Leukocyte-rich PRP vs Leukocyte-poor PRP for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial Recruiting NCT02923700 Phase 4
50 Treatment for Knee Osteoarthritis With Injections of Autologous Concentrated Bone Marrow Aspirate at the Bone-cartilage Interface Via Percutaneous. Pilot Study Active, not recruiting NCT03110666 Phase 4

Search NIH Clinical Center for Cartilage Disease

Inferred drug relations via UMLS 72 / NDF-RT 51 :


CHONDROITIN SODIUM
Chondroitin Sulfates

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Cartilage Disease cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: cartilage diseases

Genetic Tests for Cartilage Disease

Anatomical Context for Cartilage Disease

MalaCards organs/tissues related to Cartilage Disease:

41
Bone, Bone Marrow, Skin, Testes, Thyroid, Brain, Eye

Publications for Cartilage Disease

Articles related to Cartilage Disease:

(show top 50) (show all 276)
# Title Authors PMID Year
1
Correlation between the AMADEUS score and preoperative clinical patient-reported outcome measurements (PROMs) in patients undergoing matrix-induced autologous chondrocyte implantation (MACI). 17
30902098 2019
2
The Role of Orthobiologics in the Management of Osteoarthritis and Focal Cartilage Defects. 17
30889253 2019
3
pNNS-Conjugated Chitosan Mediated IGF-1 and miR-140 Overexpression in Articular Chondrocytes Improves Cartilage Repair. 17
31016187 2019
4
ADAM8 promotes chondrosarcoma cell migration and invasion by activating the NF-κB/MMP-13 signaling axis. 38
31305294 2019
5
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases. 38
31220958 2019
6
Defective WNT signaling may protect from articular cartilage deterioration - a quantitative MRI study on subjects with a heterozygous WNT1 mutation. 38
31299386 2019
7
Intra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair. 38
30954618 2019
8
Role of Epigenomics in Bone and Cartilage Disease. 38
30715766 2019
9
Osteoarthritis as an organ disease: from the cradle to the grave. 38
30698270 2019
10
Ligustrazine recovers thiram-induced tibial dyschondroplasia in chickens: Involvement of new molecules modulating integrin beta 3. 38
30388538 2019
11
Arthroscopic Hip Joint Assessment can Impact the Indications for PAO Surgery. 38
31413688 2019
12
The Clinical Evidence Behind Biologic Therapies Promoted at Annual Orthopaedic Meetings: A Systematic Review. 38
30455088 2019
13
Novel Hybrid Gels Made of High and Low Molecular Weight Hyaluronic Acid Induce Proliferation and Reduce Inflammation in an Osteoarthritis In Vitro Model Based on Human Synoviocytes and Chondrocytes. 38
31179322 2019
14
Proteomic Identification and Time-Course Monitoring of Secreted Proteins During Expansion of Human Mesenchymal Stem/Stromal in Stirred-Tank Bioreactor. 38
31297369 2019
15
Pre-Clinical Translation of Second Harmonic Microscopy of Meniscal and Articular Cartilage Using a Prototype Nonlinear Microendoscope. 38
30701146 2019
16
Treatment of Articular Cartilage Defects: Focus on Tissue Engineering. 38
30348681 2018
17
Articular Cartilage Injuries of the Knee: Patient Health Literacy, Expectations for Management, and Clinical Outcomes. 38
30486654 2018
18
On incorporating osmotic prestretch/prestress in image-driven finite element simulations of cartilage. 38
30031245 2018
19
Cartilage diseases. 38
29803938 2018
20
Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors. 38
29726060 2018
21
Human Engineered Cartilage and Decellularized Matrix as an Alternative to Animal Osteoarthritis Model. 38
30960663 2018
22
Curcumin protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in vitro. 38
29604245 2018
23
Adiponectin Downregulates TNF-α Expression in Degenerated Intervertebral Discs. 38
28767622 2018
24
Radiographic, computed tomographic, and arthroscopic diagnosis of radioulnar incongruence in dogs with medial coronoid disease. 38
29536555 2018
25
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics. 38
28827187 2018
26
Ghrelin protects against osteoarthritis through interplay with Akt and NF-κB signaling pathways. 38
29070587 2018
27
miR-27b promotes type II collagen expression by targetting peroxisome proliferator-activated receptor-γ2 during rat articular chondrocyte differentiation. 38
29187585 2018
28
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development. 38
29402405 2018
29
Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair. 38
30038551 2018
30
A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system. 38
29440889 2018
31
Stem Cells in Cartilage Diseases and Repair 2018. 38
30140290 2018
32
Different Forms of ER Stress in Chondrocytes Result in Short Stature Disorders and Degenerative Cartilage Diseases: New Insights by Cartilage-Specific ERp57 Knockout Mice. 38
30647818 2018
33
Investigating magnetic susceptibility of human knee joint at 7 Tesla. 38
28097689 2017
34
Bone-strengthening pill (BSP) promotes bone cell and chondrocyte repair, and the clinical and experimental study of BSP in the treatment of osteonecrosis of the femoral head. 38
29228594 2017
35
PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies. 38
28317389 2017
36
Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI. 38
28727417 2017
37
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. 38
28929469 2017
38
Advances in Application of Mechanical Stimuli in Bioreactors for Cartilage Tissue Engineering. 38
28463576 2017
39
Regulation of Cartilage Development and Diseases by Transcription Factors. 38
28955690 2017
40
Markers of Bone and Cartilage Turnover. 38
28444666 2017
41
Imaging of Cartilage in the Athlete. 38
28577704 2017
42
Nonoperative Options for Management of Articular Cartilage Disease. 38
28577705 2017
43
Review: Interventions for Cartilage Disease: Current State-of-the-Art and Emerging Technologies. 38
28294573 2017
44
Applications of Tissue Engineering in Joint Arthroplasty: Current Concepts Update. 38
28577777 2017
45
CK2.1, a bone morphogenetic protein receptor type Ia mimetic peptide, repairs cartilage in mice with destabilized medial meniscus. 38
28420447 2017
46
Microdrilling Surgery Augmented With Intra-articular Bone Marrow Aspirate Concentrate, Platelet-Rich Plasma, and Hyaluronic Acid: A Technique for Cartilage Repair in the Knee. 38
28409101 2017
47
Transcriptional control of chondrocyte specification and differentiation. 38
27771362 2017
48
Comparative Clinical Observation of Arthroscopic Microfracture in the Presence and Absence of a Stromal Vascular Fraction Injection for Osteoarthritis. 38
28170179 2017
49
SOX9 and the many facets of its regulation in the chondrocyte lineage. 38
27128146 2017
50
Effect of intra-articular administration of superparamagnetic iron oxide nanoparticles (SPIONs) for MRI assessment of the cartilage barrier in a large animal model. 38
29287105 2017

Variations for Cartilage Disease

Expression for Cartilage Disease

Search GEO for disease gene expression data for Cartilage Disease.

Pathways for Cartilage Disease

GO Terms for Cartilage Disease

Cellular components related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 IL1RN IHH CRP COMP COL2A1 COL10A1
2 extracellular space GO:0005615 9.5 KRT86 IL1RN IHH CRP COMP COL2A1
3 collagen-containing extracellular matrix GO:0062023 9.46 COMP COL2A1 COL10A1 ACAN
4 extracellular matrix GO:0031012 9.02 IHH COMP COL2A1 COL10A1 ACAN

Biological processes related to Cartilage Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.8 SOX6 COMP COL2A1
2 negative regulation of apoptotic process GO:0043066 9.79 SOX9 IHH COMP
3 central nervous system development GO:0007417 9.74 SOX9 COL2A1 ACAN
4 ossification GO:0001503 9.71 SOX9 IHH COL2A1
5 cell fate commitment GO:0045165 9.67 SOX9 SOX6 SOX5
6 cellular response to transforming growth factor beta stimulus GO:0071560 9.65 SOX9 SOX6 SOX5
7 collagen fibril organization GO:0030199 9.63 COL2A1 ACAN
8 chondrocyte differentiation GO:0002062 9.63 SOX9 COL2A1
9 cellular response to BMP stimulus GO:0071773 9.62 SOX9 COL2A1
10 oligodendrocyte differentiation GO:0048709 9.61 SOX9 SOX6
11 positive regulation of mesenchymal cell proliferation GO:0002053 9.6 SOX9 IHH
12 tissue homeostasis GO:0001894 9.59 SOX9 COL2A1
13 cell fate specification GO:0001708 9.58 SOX9 IHH
14 chondrocyte development GO:0002063 9.58 SOX9 ACAN
15 positive regulation of chondrocyte differentiation GO:0032332 9.58 SOX9 SOX6 SOX5
16 notochord development GO:0030903 9.56 SOX9 COL2A1
17 cartilage development GO:0051216 9.56 SOX9 SOX6 IHH COL2A1
18 limb bud formation GO:0060174 9.55 SOX9 COL2A1
19 extracellular matrix organization GO:0030198 9.55 SOX9 COMP COL2A1 COL10A1 ACAN
20 cartilage condensation GO:0001502 9.54 SOX9 COL2A1 ACAN
21 proteoglycan metabolic process GO:0006029 9.52 IHH COL2A1
22 otic vesicle development GO:0071599 9.51 SOX9 COL2A1
23 positive regulation of cartilage development GO:0061036 9.5 SOX9 SOX6 SOX5
24 anterior head development GO:0097065 9.46 SOX9 COL2A1
25 chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003413 9.43 SOX9 IHH
26 positive regulation of mesenchymal stem cell differentiation GO:2000741 9.13 SOX9 SOX6 SOX5
27 skeletal system development GO:0001501 9.1 SOX9 IHH COMP COL2A1 COL10A1 ACAN

Molecular functions related to Cartilage Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.9 TNFRSF10A SOX9 SOX6 SOX5 KRT86 IL1RN
2 calcium ion binding GO:0005509 9.56 IHH CRP COMP ACAN
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL2A1 COL10A1
4 extracellular matrix structural constituent GO:0005201 8.92 COMP COL2A1 COL10A1 ACAN

Sources for Cartilage Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
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