MCID: CTS002
MIFTS: 49

Cat-Scratch Disease

Categories: Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Cat-Scratch Disease

MalaCards integrated aliases for Cat-Scratch Disease:

Name: Cat-Scratch Disease 12 59 44 15 73
Cat Scratch Disease 76 53 43 3
Bartonellosis Due to Bartonella Henselae Infection 53 59
Cat Scratch Fever 12 53
Debre's Syndrome 12 73
Foshay-Mollaret Cat Scratch Fever 12
Benign Lymphoreticulosis 12
Debre-Mollaret Syndrome 12
Oroya Fever 73

Characteristics:

Orphanet epidemiological data:

59
cat-scratch disease
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11258
ICD10 33 A28.1
ICD9CM 35 078.3
MeSH 44 D002372
NCIt 50 C84620
SNOMED-CT 68 79974007
Orphanet 59 ORPHA50839
MESH via Orphanet 45 D002372
UMLS via Orphanet 74 C0007361 C0238909
ICD10 via Orphanet 34 A28.1

Summaries for Cat-Scratch Disease

MedlinePlus : 43 Cat scratch disease (CSD) is an illness caused by the bacterium Bartonella henselae. Almost half of all cats carry the infection at some point. The infection does not make cats sick. However, the scratch or bite of an infected cat can cause symptoms in people, including Swollen lymph nodes, especially around the head, neck, and upper limbs Fever Headache Fatigue Poor appetite For people with weak immune systems, CSD may cause more serious problems. The best way to avoid CSD is to avoid rough play with cats that could lead to scratches or bites. If you do get a scratch or bite, wash it well with soap and water. If the bite or scratch gets infected or if you have symptoms of CSD, call your doctor. Centers for Disease Control and Prevention

MalaCards based summary : Cat-Scratch Disease, also known as cat scratch disease, is related to bartonellosis and reactive arthritis, and has symptoms including abdominal pain, headache and chills. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Allograft rejection and Tuberculosis. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and eye.

Disease Ontology : 12 A bartonellosis that results in infection located in lymph node, has material basis in Bartonella henselae or has material basis in Bartonella clarridgeiae, which are transmitted by scratch or bite of a kitten, or transmitted by contact of animal's saliva with an eye or through broken skin. The infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

NIH Rare Diseases : 53 Cat scratch disease is an infectious illness caused by the bacteria bartonella (Bartonella henselae). It is believed to be transmitted by cat scratches, bites, or exposure to cat saliva. This self-limiting infectious disease is characterized by a bump or blister at the site of the bite or scratch and swelling and pain in the lymph nodes. Other features may include fatigue, headache, achiness, and fever. Although cat-scratch disease usually subsides without treatment, antibiotic and/or antimicrobial therapy may help speed recovery.

CDC : 3 Bartonella bacteria cause several diseases in humans. The most common is cat scratch disease.

Wikipedia : 76 Cat-scratch disease (CSD) is an infectious disease that results from a scratch or bite of a cat.... more...

Related Diseases for Cat-Scratch Disease

Diseases related to Cat-Scratch Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 bartonellosis 31.7 CORO1A CS EEA1 HSPD1 HTRA1
2 reactive arthritis 29.9 HSPD1 IFNG
3 chlamydia 29.8 HSPD1 IFNG
4 neuroretinitis 11.7
5 trench fever 11.6
6 intermediate uveitis 11.6
7 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.3
8 pars planitis 11.3
9 carrion's disease 11.3
10 encephalopathy 10.7
11 lymphadenitis 10.6
12 osteomyelitis 10.6
13 bacillary angiomatosis 10.4
14 status epilepticus 10.4
15 hepatitis 10.3
16 encephalitis 10.3
17 myelitis 10.3
18 purpura 10.3
19 vasculitis 10.3
20 lymphoma 10.2
21 optic neuritis 10.2
22 neuritis 10.2
23 granulomatous hepatitis 10.2
24 splenic abscess 10.2
25 neuropathy 10.2
26 transverse myelitis 10.2
27 retinal detachment 10.2
28 endocarditis 10.2
29 epidural abscess 10.2
30 uveitis 10.2
31 optic nerve disease 10.2
32 conjunctivitis 10.2
33 acquired immunodeficiency syndrome 10.2
34 systemic lupus erythematosus 10.1
35 arthritis 10.1
36 sarcoma 10.1
37 retinal vasculitis 10.1
38 aseptic meningitis 10.1
39 lymphogranuloma venereum 10.1
40 rhabdomyosarcoma 10.1
41 retinitis 10.1
42 arthropathy 10.1
43 cervical adenitis 10.1
44 suppurative lymphadenitis 10.1
45 lupus erythematosus 10.1
46 meningitis 10.1
47 spotted fever 10.1 HTRA1 IFNG
48 bacterial infectious disease 10.0 HSPD1 IFNG
49 far eastern spotted fever 10.0 HSPD1 IFNG
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 HSPD1 IFNG

Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to Cat-Scratch Disease

Symptoms & Phenotypes for Cat-Scratch Disease

Symptoms:

12
  • abdominal pain
  • headache
  • chills
  • backache
  • regional lymphadenopathy

UMLS symptoms related to Cat-Scratch Disease:


fever, pruritus

Drugs & Therapeutics for Cat-Scratch Disease

Drugs for Cat-Scratch Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Hormone Antagonists Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
6 glucocorticoids Phase 4
7 Hormones Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Gentamicins Phase 3
10 Anti-Bacterial Agents Phase 3
11 Anti-Infective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo

Search NIH Clinical Center for Cat-Scratch Disease

Cochrane evidence based reviews: cat-scratch disease

Genetic Tests for Cat-Scratch Disease

Anatomical Context for Cat-Scratch Disease

MalaCards organs/tissues related to Cat-Scratch Disease:

41
Lymph Node, Skin, Eye, Testes, Bone, Breast, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Cat-Scratch Disease:

19
Lymph Node

Publications for Cat-Scratch Disease

Articles related to Cat-Scratch Disease:

(show top 50) (show all 848)
# Title Authors Year
1
Cat-scratch disease: ocular manifestations and treatment outcome. ( 29504674 )
2018
2
Encephalopathy in an adult with cat-scratch disease. ( 29507029 )
2018
3
Bartonella henselae DNA in Seronegative Patients with Cat-Scratch Disease. ( 29664374 )
2018
4
Cat scratch disease presenting as axillary lymphadenopathy and a palpable benign mammary nodule mimicking a carcinoma. ( 29768565 )
2018
5
Cat Scratch Disease in a 1.5-year-old girl - Case report. ( 29936799 )
2018
6
Cat Scratch Disease ( 29489252 )
2018
7
Utility of Bartonella henselae IgM Western Blot Bands for Serodiagnosis of Cat Scratch Disease. ( 29093103 )
2018
8
Osteomyelitis in Cat-Scratch Disease: A Never-Ending Dilemma-A Case Report and Literature Review. ( 29808150 )
2018
9
Femoral bone lesions accompanying cat-scratch disease. ( 29572216 )
2018
10
Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. ( 29399138 )
2018
11
Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis. ( 29239936 )
2018
12
Atypical presentation of cat scratch disease: Parinaud's oculoglandular syndrome with facial nerve paresis. ( 29982178 )
2018
13
Clinical and Radiologic Manifestations of Bone Infection in Children with Cat Scratch Disease. ( 30041935 )
2018
14
Cat-Scratch Disease in an AIDS Patient Presenting with Generalized Lymphadenopathy: An Unusual Presentation with Delayed Diagnosis. ( 30068900 )
2018
15
Multifocal pelvic osteomyelitis in a child associated with a cat-scratch disease: a case report and review of the literature. ( 30092749 )
2018
16
Transverse Myelitis and Guillain-Barré Syndrome Associated with Cat-Scratch Disease, Texas, USA, 2011. ( 30124417 )
2018
17
Skull osteomyelitis as a rare complication of cat scratch disease. ( 30319958 )
2018
18
Parinaud's Oculoglandular Syndrome in Cat Scratch Disease. ( 30380392 )
2018
19
Seronegative cat scratch disease in a patient with systemic lupus erythematosus. ( 30414376 )
2018
20
Lymph node syndrome associated with cat scratch disease in children and adults. ( 30441948 )
2018
21
Effectiveness of antibiotic therapy in pediatric patients with cat scratch disease. ( 30446895 )
2018
22
Cat scratch disease. Onset as epithroclear tumor. ( 28416228 )
2017
23
Disseminated cat-scratch disease presenting as nausea, diarrhea, and weight loss without fever in a heart transplant recipient. ( 28199763 )
2017
24
Cat scratch disease during etanercept therapy in a rheumatoid arthritis patient. ( 28256443 )
2017
25
Detection of Bartonella in cat scratch disease using a single-step PCR assay kit. ( 29068281 )
2017
26
Torticollis and Fever in a Young Boy: A Unique Presentation of Cat-Scratch Disease With Vertebral Osteomyelitis and Epidural Phlegmon. ( 29095386 )
2017
27
Cat Scratch Disease: Not a Benign Condition. ( 28665750 )
2017
28
Cat Scratch Disease During Adalimumab Therapy: A Case Report. ( 29132747 )
2017
29
Diverse Clinical Signs of Ocular Involvement in Cat Scratch Disease. ( 28182175 )
2017
30
Cat-Scratch Disease: A Pitfall for Lymphoma Evaluation by FDG-PET/CT. ( 27997427 )
2017
31
A pediatric case with peripheral facial nerve palsy caused by a granulomatous lesion associated with cat scratch disease. ( 28935172 )
2017
32
Cat scratch disease: U.S. clinicians' experience and knowledge. ( 28707827 )
2017
33
CAT SCRATCH DISEASE IMITATING A TOXOCARA GRANULOMA OF THE OPTIC DISK. ( 29176527 )
2017
34
Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease. ( 28669017 )
2017
35
Cat Scratch Disease in a Renal Transplant Recipient. ( 27312684 )
2016
36
Development of a Highly Specific IgM Enzyme-Linked Immunosorbent Assay for Bartonella henselae Using Refined N-Lauroyl-Sarcosine-Insoluble Proteins for Serodiagnosis of Cat Scratch Disease. ( 26865692 )
2016
37
Cat-scratch disease presenting as parotid gland abscess and aseptic meningitis. ( 27426218 )
2016
38
Disseminated cat-scratch disease: case report and review of the literature. ( 27077606 )
2016
39
Corticosteroid Treatment for Prolonged Fever in Hepatosplenic Cat-Scratch Disease. ( 28006985 )
2016
40
Cat-Scratch Disease in the United States, 2005-2013. ( 27648778 )
2016
41
Cat-scratch disease with hepatosplenic lesions in two brothers. ( 27051576 )
2016
42
The utility of a country-specific Bartonella henselae antigen in an IgM-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease. ( 28029424 )
2016
43
Disseminated cat-scratch disease in an adult with selective IgA deficiency. ( 27257449 )
2016
44
Cat Scratch Disease: Expanded Spectrum. ( 27843905 )
2016
45
Epitrochlear cat scratch disease: unique imaging features allowing differentiation from other soft tissue masses of the medial arm. ( 27193359 )
2016
46
Atypical Cat Scratch Disease With Hepatosplenic Involvement. ( 27484614 )
2016
47
Thoracic osteomyelitis and epidural abscess formation due to cat scratch disease: case report. ( 27662446 )
2016
48
Cat scratch disease in 9-year-old patient - a case report. ( 27213258 )
2016
49
Multifocal splenic abscesses in immunocompetent adult due to cat-scratch disease. ( 29416305 )
2016
50
Evaluation of Cat Scratch Disease Cases Reported from Turkey between 1996 and 2013 and Review of the Literature. ( 26851430 )
2015

Variations for Cat-Scratch Disease

Expression for Cat-Scratch Disease

Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for Cat-Scratch Disease

GO Terms for Cat-Scratch Disease

Cellular components related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 CORO1A CS EEA1 HSPD1 HTRA1
2 early endosome GO:0005769 8.8 CORO1A EEA1 HSPD1

Biological processes related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic apoptotic signaling pathway GO:0097191 9.26 IFNG TNFRSF1B
2 positive regulation of interleukin-12 production GO:0032735 9.16 HSPD1 IFNG
3 positive regulation of T cell activation GO:0050870 8.96 CORO1A HSPD1
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 IFNG TNFRSF1B

Sources for Cat-Scratch Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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