Cat-Scratch Disease

Categories: Immune diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Cat-Scratch Disease

MalaCards integrated aliases for Cat-Scratch Disease:

Name: Cat-Scratch Disease 12 58 44 15 17 70 32
Cat Scratch Disease 73 20 42 3
Bartonellosis Due to Bartonella Henselae Infection 20 58
Cat Scratch Fever 12 20
Debre's Syndrome 12 70
Foshay-Mollaret Cat Scratch Fever 12
Benign Lymphoreticulosis 12
Debre-Mollaret Syndrome 12
Oroya Fever 70


Orphanet epidemiological data:

cat-scratch disease
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;


Orphanet: 58  
Rare infectious diseases

External Ids:

Disease Ontology 12 DOID:11258
ICD9CM 34 078.3
MeSH 44 D002372
NCIt 50 C84620
SNOMED-CT 67 123319006
ICD10 32 A28.1
MESH via Orphanet 45 D002372
ICD10 via Orphanet 33 A28.1
UMLS via Orphanet 71 C0007361 C0238909
Orphanet 58 ORPHA50839
UMLS 70 C0007361 C0029307 C0543786

Summaries for Cat-Scratch Disease

GARD : 20 Cat scratch disease (CSD) is a bacterial infection that primarily affects the lymph nodes. It is typically caused by the bacteria bartonella ( Bartonella henselae ). It is usually transmitted by being scratched or bitten by a cat, but rarely, no scratch or bite is involved. Symptoms frequently include the formation of a small bump at the site of the scratch or bite, followed by fever and swollen lymph nodes (lymphadenopathy) within 1-3 weeks. Lymphadenopathy commonly resolves on its own within a few months, but in some cases it may persist for up to 2 years. People with weakened immune systems (and less commonly, people with healthy immune systems) may develop more widespread disease and additional symptoms or neurological complications, which can be severe. In most cases, particularly in children and adolescents, having CSD once means that it cannot occur again. The recurrence of symptoms months after disease onset has been reported in a few adults with CSD. Treatment in mild or moderate cases typically involves medicines or strategies to improve symptoms, such as using fever reducers, pain relievers, or local heat over the affected lymph node(s). In more severe or systemic cases, management may involve lymph node aspiration and/or antibiotics.

MalaCards based summary : Cat-Scratch Disease, also known as cat scratch disease, is related to neuroretinitis and endocarditis, and has symptoms including abdominal pain, headache and chills. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA Serine Peptidase 1). The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, eye and skin.

Disease Ontology : 12 A bartonellosis that results in infection located in lymph node, has material basis in Bartonella henselae or has material basis in Bartonella clarridgeiae, which are transmitted by scratch or bite of a kitten, or transmitted by contact of animal's saliva with an eye or through broken skin. The infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

MedlinePlus : 42 Cat scratch disease (CSD) is an illness caused by the bacterium Bartonella henselae. Almost half of all cats carry the infection at some point. The infection does not make cats sick. However, the scratch or bite of an infected cat can cause symptoms in people, including Swollen lymph nodes, especially around the head, neck, and upper limbs Fever Headache Fatigue Poor appetite For people with weak immune systems, CSD may cause more serious problems. The best way to avoid CSD is to avoid rough play with cats that could lead to scratches or bites. If you do get a scratch or bite, wash it well with soap and water. If the bite or scratch gets infected or if you have symptoms of CSD, call your doctor. Centers for Disease Control and Prevention

CDC : 3 Cat-scratch disease (CSD) is a bacterial infection spread by cats. The disease spreads when an infected cat licks a person's open wound, or bites or scratches a person hard enough to break the surface of the skin. About three to 14 days after the skin is broken, a mild infection can occur at the site of the scratch or bite. The infected area may appear swollen and red with round, raised lesions and can have pus. The infection can feel warm or painful. A person with CSD may also have a fever, headache, poor appetite, and exhaustion. Later, the person's lymph nodes closest to the original scratch or bite can become swollen, tender, or painful.

Wikipedia : 73 Cat-scratch disease (CSD) or felinosis is an infectious disease that most often results from a scratch... more...

Related Diseases for Cat-Scratch Disease

Diseases related to Cat-Scratch Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)
# Related Disease Score Top Affiliating Genes
1 neuroretinitis 31.7 CS CRP CD4 ACE
2 endocarditis 31.2 HTRA1 HSPD1 CRP
3 ornithosis 30.8 HTRA1 CRP
4 bacillary angiomatosis 30.7 PPP1R14A HTRA1 HSPD1 CS CD4
5 epidural abscess 30.7 CRP CD4
6 splenic abscess 30.7 CRP CD4
7 chlamydia 30.7 HTRA1 HSPD1 CRP
8 granulomatous hepatitis 30.7 CRP CD4 ACE
9 carrion's disease 30.6 PPP1R14A HSPD1 CS
10 suppurative lymphadenitis 30.6 CRP CD4
11 cervical adenitis 30.6 HSPD1 CRP CD4
12 optic papillitis 30.6 CRP CD4 ACE
13 choroiditis 30.5 HTRA1 CD4 ACE
14 inclusion conjunctivitis 30.5 HTRA1 HSPD1
15 chorioretinitis 30.4 CRP CD4 ACE
16 lymph node tuberculosis 30.4 CRP CD4
17 bacterial infectious disease 30.4 HSPD1 CRP CD4
18 exanthem 30.3 CRP CD4 ACE
19 disease by infectious agent 30.3 TNFRSF8 HSPD1 CRP CD4
20 iridocyclitis 30.3 CRP CD4 ACE
21 constrictive pericarditis 30.3 CRP ACE
22 relapsing fever 30.2 HSPD1 CRP
23 retinal vasculitis 30.2 CD4 ACE
24 orbital granuloma 30.2 CRP ACE
25 sarcoidosis 1 30.2 CRP CD4 ACE
26 papilledema 30.2 CRP CD4 ACE
27 facial paralysis 30.2 CRP CD4 ACE
28 syphilis 30.2 CRP CD4 ACE
29 lymphangitis 30.1 CRP CD4
30 urethritis 30.1 HSPD1 CRP CD4
31 lymph node disease 30.0 HSPD1 CRP CD4
32 kawasaki disease 30.0 HSPD1 CRP CD4
33 panuveitis 29.8 CRP CD4 ACE
34 ehrlichiosis 29.8 HSPD1 CD4 ANKRD46
35 bartonellosis 29.8 TNFRSF8 PPP1R14A HTRA1 HSPD1 EXOSC5 CS
36 urticaria 29.8 CRP CD4 ACE
37 tularemia 29.7 HSPD1 CD4
38 pars planitis 11.2
39 intermediate uveitis 11.2
40 lymphadenitis 11.0
41 osteomyelitis 10.8
42 angiomatosis 10.8
43 encephalopathy 10.8
44 erythema nodosum 10.7
45 uveitis 10.6
46 retinal detachment 10.6
47 neuritis 10.5
48 status epilepticus 10.5
49 retinitis 10.5
50 encephalitis 10.5

Graphical network of the top 20 diseases related to Cat-Scratch Disease:

Diseases related to Cat-Scratch Disease

Symptoms & Phenotypes for Cat-Scratch Disease


  • abdominal pain
  • headache
  • chills
  • backache
  • regional lymphadenopathy

UMLS symptoms related to Cat-Scratch Disease:

fever; pruritus

Drugs & Therapeutics for Cat-Scratch Disease

Drugs for Cat-Scratch Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

# Name Status Phase Clinical Trials Cas Number PubChem Id
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
Azithromycin Approved Phase 3 83905-01-5 55185 447043
3 Anti-Bacterial Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Gentamicins Phase 3

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis: A Randomized Controlled Study Recruiting NCT03132116 Phase 3 gentamicin;placebo

Search NIH Clinical Center for Cat-Scratch Disease

Cochrane evidence based reviews: cat-scratch disease

Genetic Tests for Cat-Scratch Disease

Anatomical Context for Cat-Scratch Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Cat-Scratch Disease:

Lymph Node

MalaCards organs/tissues related to Cat-Scratch Disease:

Lymph Node, Eye, Skin, Bone, Bone Marrow, Kidney, Lung

Publications for Cat-Scratch Disease

Articles related to Cat-Scratch Disease:

(show top 50) (show all 1806)
# Title Authors PMID Year
Think about cats in acute vision loss. 42 61
33444310 2021
Bartonella Neuroretinitis. 42
33705615 2021
Shoulder Pain in a Weight-lifting Adolescent Athlete: A Zoonotic Etiology. 42
33306513 2020
Clinical profile and visual outcome of intraocular inflammation associated with cat-scratch disease in Japanese patients. 61
33797675 2021
Epidemiological of cat scratch disease among inpatients in the Spanish health system (1997-2015). 61
33118059 2021
Systemic Cat-Scratch Disease: a "Troublesome" Diagnosis. 61
33230057 2021
Bartonella henselae Antibodies in Serum and Oral Fluid Specimens from Cats. 61
33799577 2021
Bartonella henselae IgM seropositivity in both adult and pediatric patients with diverse clinical conditions in Turkey. 61
33661136 2021
Hemorrhage and Rupture of an Unusual Benign Liver Lesion in Pregnancy: A Case Report. 61
33746452 2021
Hepatosplenic Bartonellosis in an Immunocompetent Teenager: An Atypical Presentation of Cat-Scratch Disease. 61
33717753 2021
Molecular and Serological Survey of the Cat-Scratch Disease Agent (Bartonella henselae) in Free-Ranging Leopardus geoffroyi and Leopardus wiedii (Carnivora: Felidae) From Pampa Biome, Brazil. 61
32974747 2021
[Cat-scratch disease with multiple bone involvement]. 61
33458999 2021
Infections in Patients with Chronic Granulomatous Disease Treated with Tumor Necrosis Factor Alpha Blockers for Inflammatory Complications. 61
33150502 2021
[Cat scratch disease]. 61
33449053 2021
Cat Scratch Disease: The First Case Report in Republic of North Macedonia. 61
33500373 2020
Detection of Bartonella sp. in ticks and their small mammal hosts in mangrove forests of Peninsular Malaysia. 61
33612746 2020
Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome. 61
33389938 2020
Ocular complications of cat scratch disease. 61
32122915 2020
Bartonella neuroretinitis (cat-scratch disease). 61
32546517 2020
Cat Scratch Disease Presenting as Fever of Unknown Origin Is a Unique Clinical Syndrome. 61
31758684 2020
Cat-Scratch Disease Masquerading as C3 Glomerulonephritis. 61
33305138 2020
Molecular detection of Bartonella henselae, Bartonella clarridgeiae and Rickettsia felis in cat and dog fleas in Tenerife, Canary Islands, Spain. 61
33207065 2020
Pediatric Bartonella henselae Infection: The Role of Serologic Diagnosis and a Proposed Clinical Approach for Suspected Acute Disease in the Immunocompetent Child. 61
32826721 2020
Combined Application of Immunohistochemistry and Warthin-Starry Silver Stain on the Pathologic Diagnosis of Cat Scratch Disease. 61
31913159 2020
Hepatosplenic cat scratch disease: The usefulness of liver biopsy. 61
33230753 2020
[Binocular Asymmetric Manifestation of Cat-Scratch Disease Due to Bartonella Henselae Infection in an Immunosuppressed Patient]. 61
33242882 2020
Bartonella hanselae retinitis patient evaluated with multimodal retinal exams. 61
33292796 2020
The clinical spectrum of ocular bartonellosis: a retrospective study at a tertiary centre in Malaysia. 61
33191467 2020
Transmission of Bartonella henselae within Rhipicephalus sanguineus: Data on the Potential Vector Role of the Tick. 61
33001978 2020
"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses. 61
32470708 2020
Cat-scratch Disease in the Pediatric Population: 6 Years of Evaluation and Follow-up in a Public Hospital in Chile. 61
32404788 2020
The flea's knees: A unique presentation of cat scratch disease. 61
33129648 2020
Effectiveness of Magnetic Resonance Imaging Examination for the Diagnosis of Pediatric Cat-scratch Disease. 61
32936600 2020
Improved diagnosis of cat-scratch disease with an IgM enzyme-linked immunosorbent assay for Bartonella henselae using N-lauroyl-sarcosine-insoluble protein antigen. 61
32437955 2020
Corrigendum to "Lack of restricted diffusion in MR imaging as a potential differentiating tool of reactive lymph node in cat scratch disease from lymphoma or abscess" [Radiology Case Reports 15 (2020) 1180-1183]. 61
32774581 2020
Serosurvey of IgG Antibodies against Bartonella henselae and Rickettsia typhi in the Population of Attica, Greece. 61
32947795 2020
Erythema Nodosum: An Unusual Clinical Manifestation of Oropharyngeal Tularemia. 61
33123422 2020
Neuroretinitis caused by Bartonella henselae in Gipuzkoa, 2014-2019. 61
32950265 2020
Bartonella henselae encephalopathy in a paediatric patient: A case report and treatment review. 61
32419222 2020
[Bartonella henselae with atypical infection and neuroretinitis in a pediatric unit: report of three cases]. 61
33399668 2020
Lack of restricted diffusion in MR imaging as a potential differentiating tool of reactive lymph node in cat scratch disease from lymphoma or abscess. 61
32547675 2020
Granulomatous inflammation in lymph nodes of the head and neck-a retrospective analysis of causes in a population with very low incidence of tuberculosis. 61
32681498 2020
Parinaud's Oculoglandular Syndrome: A Case in an Adult with Flea-Borne Typhus and a Review. 61
32751142 2020
Cat Scratch Disease Is an Entity Often Diagnosed in Breast Imaging Department During Axillary Lymph Node Assessment. 61
32821616 2020
Atypical Manifestations of Cat-Scratch Disease, United States, 2005-2014. 61
32568056 2020
[Cat-scratch disease]. 61
32779899 2020
Cat scratch disease causing encephalitis. 61
32675979 2020
Detection of Flea-Borne Pathogens from Cats and Fleas in a Maltese Shelter. 61
32267802 2020
Long-term outcome of surgical excision for treatment of cervicofacial granulomatous lymphadenitis in children. 61
32144570 2020
Disseminated Cat Scratch Disease in Pediatric Patients in Hawai'i. 61
32490388 2020

Variations for Cat-Scratch Disease

Expression for Cat-Scratch Disease

Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for Cat-Scratch Disease

GO Terms for Cat-Scratch Disease

Biological processes related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell activation GO:0050870 8.62 HSPD1 CD4

Sources for Cat-Scratch Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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