MCID: CTS002
MIFTS: 50

Cat-Scratch Disease

Categories: Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Cat-Scratch Disease

MalaCards integrated aliases for Cat-Scratch Disease:

Name: Cat-Scratch Disease 12 59 44 15 73
Cat Scratch Disease 76 53 43 3
Bartonellosis Due to Bartonella Henselae Infection 53 59
Cat Scratch Fever 12 53
Debre's Syndrome 12 73
Foshay-Mollaret Cat Scratch Fever 12
Benign Lymphoreticulosis 12
Debre-Mollaret Syndrome 12
Oroya Fever 73

Characteristics:

Orphanet epidemiological data:

59
cat-scratch disease
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11258
ICD10 33 A28.1
ICD9CM 35 078.3
MeSH 44 D002372
NCIt 50 C84620
Orphanet 59 ORPHA50839
MESH via Orphanet 45 D002372
UMLS via Orphanet 74 C0007361 C0238909
ICD10 via Orphanet 34 A28.1

Summaries for Cat-Scratch Disease

MedlinePlus : 43 Cat scratch disease (CSD) is an illness caused by the bacterium Bartonella henselae. Almost half of all cats carry the infection at some point. The infection does not make cats sick. However, the scratch or bite of an infected cat can cause symptoms in people, including Swollen lymph nodes, especially around the head, neck, and upper limbs Fever Headache Fatigue Poor appetite For people with weak immune systems, CSD may cause more serious problems. The best way to avoid CSD is to avoid rough play with cats that could lead to scratches or bites. If you do get a scratch or bite, wash it well with soap and water. If the bite or scratch gets infected or if you have symptoms of CSD, call your doctor. Centers for Disease Control and Prevention

MalaCards based summary : Cat-Scratch Disease, also known as cat scratch disease, is related to neuroretinitis and carrion's disease, and has symptoms including regional lymphadenopathy, headache and chills. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Tuberculosis. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lymph node and skin.

Disease Ontology : 12 A bartonellosis that results in infection located in lymph node, has material basis in Bartonella henselae or has material basis in Bartonella clarridgeiae, which are transmitted by scratch or bite of a kitten, or transmitted by contact of animal's saliva with an eye or through broken skin. The infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

NIH Rare Diseases : 53 Cat scratch disease is an infectious illness caused by the bacteria bartonella (Bartonella henselae). It is believed to be transmitted by cat scratches, bites, or exposure to cat saliva. This self-limiting infectious disease is characterized by a bump or blister at the site of the bite or scratch and swelling and pain in the lymph nodes. Other features may include fatigue, headache, achiness, and fever. Although cat-scratch disease usually subsides without treatment, antibiotic and/or antimicrobial therapy may help speed recovery.

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Wikipedia : 76 Cat-scratch disease (CSD) is a common and usually benign infectious disease caused by the bacterium... more...

Related Diseases for Cat-Scratch Disease

Diseases related to Cat-Scratch Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 neuroretinitis 32.6 CD40LG CS
2 carrion's disease 32.2 CD40LG HSPD1
3 ehrlichiosis 30.3 CD40LG HSPD1
4 bartonellosis 30.2 CD40LG CS EEA1 HSPD1 HTRA1
5 q fever 30.2 CD40LG IFNG
6 brucellosis 30.1 CD40LG IFNG
7 lyme disease 30.1 CD40LG HSPD1
8 toxoplasmosis 30.0 CD40LG IFNG
9 meningitis 30.0 CD40LG IFNG
10 reactive arthritis 29.9 HSPD1 IFNG
11 acquired immunodeficiency syndrome 29.9 CD40LG IFNG
12 chlamydia 29.4 CD40LG HSPD1 IFNG
13 trench fever 11.4
14 intermediate uveitis 11.4
15 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.1
16 pars planitis 11.1
17 post-vaccinal encephalitis 10.6 CD40LG HTRA1
18 osteomyelitis 10.5
19 encephalopathy 10.4
20 angiomatosis 10.4
21 spotted fever 10.4 HTRA1 IFNG
22 african tick-bite fever 10.4 CD40LG IFNG
23 hepatitis 10.4
24 lymphadenitis 10.4
25 retinitis 10.4
26 sporotrichosis 10.4 CD40LG IFNG
27 fallopian tube disease 10.4 CD40LG HSPD1
28 cutaneous lupus erythematosus 10.4 CD40LG EEA1
29 salpingitis 10.4 CD40LG HSPD1
30 urethritis 10.4 CD40LG HSPD1
31 buruli ulcer 10.4 CD40LG IFNG
32 human granulocytic anaplasmosis 10.4 CD40LG HSPD1
33 primary systemic mycosis 10.4 CD40LG IFNG
34 coccidiosis 10.4 CD40LG IFNG
35 hemorrhagic fever 10.4 CD40LG IFNG
36 endocardium disease 10.3 CD40LG HSPD1
37 lichen disease 10.3 CD40LG IFNG
38 plasmodium vivax malaria 10.3 CD40LG IFNG
39 hepatitis e 10.3 CD40LG IFNG
40 hypersensitivity reaction type iv disease 10.3 CD40LG IFNG
41 pelvic inflammatory disease 10.3 CD40LG HSPD1
42 bacillary angiomatosis 10.3
43 opportunistic mycosis 10.3 CD40LG IFNG
44 vernal conjunctivitis 10.3 CD40LG IFNG
45 echinococcosis 10.3 CD40LG IFNG
46 status epilepticus 10.3
47 dengue hemorrhagic fever 10.3 CD40LG IFNG
48 far eastern spotted fever 10.3 HSPD1 IFNG
49 mumps 10.3 CD40LG IFNG
50 human immunodeficiency virus infectious disease 10.2 CD40LG IFNG

Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to Cat-Scratch Disease

Symptoms & Phenotypes for Cat-Scratch Disease

Symptoms:

12
  • regional lymphadenopathy
  • headache
  • chills
  • backache
  • abdominal pain

UMLS symptoms related to Cat-Scratch Disease:


fever, pruritus

Drugs & Therapeutics for Cat-Scratch Disease

Drugs for Cat-Scratch Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 glucocorticoids Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Gentamicins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo

Search NIH Clinical Center for Cat-Scratch Disease

Cochrane evidence based reviews: cat-scratch disease

Genetic Tests for Cat-Scratch Disease

Anatomical Context for Cat-Scratch Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Cat-Scratch Disease:

19
Lymph Node

MalaCards organs/tissues related to Cat-Scratch Disease:

41
Lymph Node, Skin, Eye, Bone, Testes, Breast, Liver

Publications for Cat-Scratch Disease

Articles related to Cat-Scratch Disease:

(show top 50) (show all 576)
# Title Authors Year
1
Cat-scratch disease: ocular manifestations and treatment outcome. ( 29504674 )
2018
2
Encephalopathy in an adult with cat-scratch disease. ( 29507029 )
2018
3
Bartonella henselae DNA in Seronegative Patients with Cat-Scratch Disease. ( 29664374 )
2018
4
Cat scratch disease presenting as axillary lymphadenopathy and a palpable benign mammary nodule mimicking a carcinoma. ( 29768565 )
2018
5
Cat Scratch Disease in a 1.5-year-old girl - Case report. ( 29936799 )
2018
6
Cat Scratch Disease ( 29489252 )
2018
7
Utility of Bartonella henselae IgM Western Blot Bands for Serodiagnosis of Cat Scratch Disease. ( 29093103 )
2018
8
Osteomyelitis in Cat-Scratch Disease: A Never-Ending Dilemma-A Case Report and Literature Review. ( 29808150 )
2018
9
Femoral bone lesions accompanying cat-scratch disease. ( 29572216 )
2018
10
Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. ( 29399138 )
2018
11
Cat scratch disease. Onset as epithroclear tumor. ( 28416228 )
2017
12
Disseminated cat-scratch disease presenting as nausea, diarrhea, and weight loss without fever in a heart transplant recipient. ( 28199763 )
2017
13
Cat scratch disease during etanercept therapy in a rheumatoid arthritis patient. ( 28256443 )
2017
14
Detection of Bartonella in cat scratch disease using a single-step PCR assay kit. ( 29068281 )
2017
15
Torticollis and Fever in a Young Boy: A Unique Presentation of Cat-Scratch Disease With Vertebral Osteomyelitis and Epidural Phlegmon. ( 29095386 )
2017
16
Cat Scratch Disease: Not a Benign Condition. ( 28665750 )
2017
17
Cat Scratch Disease During Adalimumab Therapy: A Case Report. ( 29132747 )
2017
18
Diverse Clinical Signs of Ocular Involvement in Cat Scratch Disease. ( 28182175 )
2017
19
Cat-Scratch Disease: A Pitfall for Lymphoma Evaluation by FDG-PET/CT. ( 27997427 )
2017
20
A pediatric case with peripheral facial nerve palsy caused by a granulomatous lesion associated with cat scratch disease. ( 28935172 )
2017
21
Cat scratch disease: U.S. clinicians' experience and knowledge. ( 28707827 )
2017
22
CAT SCRATCH DISEASE IMITATING A TOXOCARA GRANULOMA OF THE OPTIC DISK. ( 29176527 )
2017
23
Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease. ( 28669017 )
2017
24
Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis. ( 29239936 )
2017
25
Cat Scratch Disease in a Renal Transplant Recipient. ( 27312684 )
2016
26
Development of a Highly Specific IgM Enzyme-Linked Immunosorbent Assay for Bartonella henselae Using Refined N-Lauroyl-Sarcosine-Insoluble Proteins for Serodiagnosis of Cat Scratch Disease. ( 26865692 )
2016
27
Cat-scratch disease presenting as parotid gland abscess and aseptic meningitis. ( 27426218 )
2016
28
Disseminated cat-scratch disease: case report and review of the literature. ( 27077606 )
2016
29
Corticosteroid Treatment for Prolonged Fever in Hepatosplenic Cat-Scratch Disease. ( 28006985 )
2016
30
Cat-Scratch Disease in the United States, 2005-2013. ( 27648778 )
2016
31
Cat-scratch disease with hepatosplenic lesions in two brothers. ( 27051576 )
2016
32
The utility of a country-specific Bartonella henselae antigen in an IgM-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease. ( 28029424 )
2016
33
Disseminated cat-scratch disease in an adult with selective IgA deficiency. ( 27257449 )
2016
34
Cat Scratch Disease: Expanded Spectrum. ( 27843905 )
2016
35
Epitrochlear cat scratch disease: unique imaging features allowing differentiation from other soft tissue masses of the medial arm. ( 27193359 )
2016
36
Atypical Cat Scratch Disease With Hepatosplenic Involvement. ( 27484614 )
2016
37
Thoracic osteomyelitis and epidural abscess formation due to cat scratch disease: case report. ( 27662446 )
2016
38
Cat scratch disease in 9-year-old patient - a case report. ( 27213258 )
2016
39
Evaluation of Cat Scratch Disease Cases Reported from Turkey between 1996 and 2013 and Review of the Literature. ( 26851430 )
2015
40
Hepatosplenic Cat-Scratch Disease in Children and the Positive Contribution of 18F-FDG Imaging. ( 26164171 )
2015
41
Cat scratch disease in an immunosuppressed patient with systemic lupus erythematosus. ( 26453661 )
2015
42
Posterior segment involvement in cat-scratch disease: A case series. ( 26545331 )
2015
43
Cat-scratch disease presenting as a solitary splenic abscess in an elderly man. ( 25804947 )
2015
44
Atypical manifestation of cat-scratch disease: isolated epigastric pain in an immunocompetent, 12-year-old child. ( 26273467 )
2015
45
Disseminated cat-scratch disease: case report and review of the literature. ( 25940800 )
2015
46
Persistent cat scratch disease requiring surgical excision in a patient with MPGN. ( 25963015 )
2015
47
Cat scratch disease during infliximab therapy: a case report and literature review. ( 25547623 )
2015
48
Progressive Cat Scratch Disease Despite Antimicrobial Therapy. ( 26407443 )
2015
49
Hepatosplenic Abscesses and Osteomyelitis of the Spine in an Immunocompetent Adult with Cat Scratch Disease. ( 26576306 )
2015
50
Multiple Renal and Splenic Lesions in a Child with Cat Scratch Disease. ( 26567841 )
2015

Variations for Cat-Scratch Disease

Expression for Cat-Scratch Disease

Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for Cat-Scratch Disease

Pathways related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 CD40LG IFNG
2 11.18 CORO1A EEA1 HSPD1 IFNG
3
Show member pathways
11.12 CD40LG IFNG
4 11.05 CS HSPD1
5 10.85 CD40LG IFNG
6 10.47 CD40LG IFNG

GO Terms for Cat-Scratch Disease

Cellular components related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 CORO1A CS EEA1 HSPD1 HTRA1
2 early endosome GO:0005769 8.8 CORO1A EEA1 HSPD1

Biological processes related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.32 CD40LG CORO1A
2 B cell proliferation GO:0042100 9.26 CD40LG HSPD1
3 positive regulation of T cell activation GO:0050870 9.16 CORO1A HSPD1
4 positive regulation of interleukin-10 production GO:0032733 8.96 CD40LG HSPD1
5 positive regulation of interleukin-12 production GO:0032735 8.8 CD40LG HSPD1 IFNG

Sources for Cat-Scratch Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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