MCID: CTS002
MIFTS: 49

Cat-Scratch Disease

Categories: Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Cat-Scratch Disease

MalaCards integrated aliases for Cat-Scratch Disease:

Name: Cat-Scratch Disease 12 60 45 15 17 74
Cat Scratch Disease 77 54 44 3
Bartonellosis Due to Bartonella Henselae Infection 54 60
Cat Scratch Fever 12 54
Debre's Syndrome 12 74
Foshay-Mollaret Cat Scratch Fever 12
Benign Lymphoreticulosis 12
Debre-Mollaret Syndrome 12
Oroya Fever 74

Characteristics:

Orphanet epidemiological data:

60
cat-scratch disease
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11258
ICD9CM 36 078.3
MeSH 45 D002372
NCIt 51 C84620
SNOMED-CT 69 79974007
ICD10 34 A28.1
MESH via Orphanet 46 D002372
ICD10 via Orphanet 35 A28.1
UMLS via Orphanet 75 C0007361 C0238909
Orphanet 60 ORPHA50839

Summaries for Cat-Scratch Disease

NIH Rare Diseases : 54 Cat scratch disease (CSD) is a bacterial infection that primarily affects the lymph nodes. It is typically caused by the bacteria bartonella (Bartonella henselae). It is usually transmitted by being scratched or bitten by a cat, but rarely, no scratch or bite is involved. Symptoms frequently include the formation of a small bump at the site of the scratch or bite, followed by fever and swollen lymph nodes (lymphadenopathy) within 1-3 weeks. Lymphadenopathy commonly resolves on its own within a few months, but in some cases it may persist for up to 2 years. People with weakened immune systems (and less commonly, people with healthy immune systems) may develop more widespread disease and additional symptoms or neurological complications, which can be severe. In most cases, particularly in children and adolescents, having CSD once means that it cannot occur again. The recurrence of symptoms months after disease onset has been reported in a few adults with CSD. Treatment in mild or moderate cases typically involves medicines or strategies to improve symptoms, such as using fever reducers, pain relievers, or local heat over the affected lymph node(s). In more severe or systemic cases, management may involve lymph node aspiration and/or antibiotics.

MalaCards based summary : Cat-Scratch Disease, also known as cat scratch disease, is related to bartonellosis and reactive arthritis, and has symptoms including abdominal pain, headache and chills. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Allograft rejection and Tuberculosis. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and eye.

Disease Ontology : 12 A bartonellosis that results in infection located in lymph node, has material basis in Bartonella henselae or has material basis in Bartonella clarridgeiae, which are transmitted by scratch or bite of a kitten, or transmitted by contact of animal's saliva with an eye or through broken skin. The infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

MedlinePlus : 44 Cat scratch disease (CSD) is an illness caused by the bacterium Bartonella henselae. Almost half of all cats carry the infection at some point. The infection does not make cats sick. However, the scratch or bite of an infected cat can cause symptoms in people, including Swollen lymph nodes, especially around the head, neck, and upper limbs Fever Headache Fatigue Poor appetite For people with weak immune systems, CSD may cause more serious problems. The best way to avoid CSD is to avoid rough play with cats that could lead to scratches or bites. If you do get a scratch or bite, wash it well with soap and water. If the bite or scratch gets infected or if you have symptoms of CSD, call your doctor. Centers for Disease Control and Prevention

CDC : 3 Bartonella bacteria cause several diseases in humans. The most common is cat scratch disease.

Wikipedia : 77 Cat-scratch disease (CSD) is an infectious disease that results from a scratch or bite of a cat.... more...

Related Diseases for Cat-Scratch Disease

Diseases related to Cat-Scratch Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 bartonellosis 31.9 CORO1A EEA1 HSPD1 HTRA1
2 reactive arthritis 29.6 HSPD1 IFNG
3 chlamydia 29.5 HSPD1 IFNG
4 bone inflammation disease 29.4 IFNG TNFRSF1B
5 neuroretinitis 11.7
6 trench fever 11.6
7 pars planitis 11.6
8 intermediate uveitis 11.6
9 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.3
10 carrion's disease 11.3
11 encephalopathy 10.7
12 lymphadenitis 10.6
13 osteomyelitis 10.6
14 bacillary angiomatosis 10.4
15 status epilepticus 10.4
16 hepatitis 10.3
17 encephalitis 10.3
18 myelitis 10.3
19 purpura 10.3
20 vasculitis 10.3
21 lymphoma 10.3
22 optic neuritis 10.3
23 neuritis 10.3
24 granulomatous hepatitis 10.3
25 splenic abscess 10.3
26 acquired immunodeficiency syndrome 10.3
27 neuropathy 10.3
28 transverse myelitis 10.3
29 retinal detachment 10.2
30 endocarditis 10.2
31 epidural abscess 10.2
32 uveitis 10.2
33 facial paralysis 10.2
34 optic nerve disease 10.2
35 conjunctivitis 10.2
36 breast cancer 10.1
37 systemic lupus erythematosus 10.1
38 arthritis 10.1
39 joint disorders 10.1
40 sarcoma 10.1
41 ornithosis 10.1
42 retinal vasculitis 10.1
43 lyme disease 10.1
44 aseptic meningitis 10.1
45 lymphogranuloma venereum 10.1
46 rhabdomyosarcoma 10.1
47 retinitis 10.1
48 arthropathy 10.1
49 cervical adenitis 10.1
50 suppurative lymphadenitis 10.1

Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to Cat-Scratch Disease

Symptoms & Phenotypes for Cat-Scratch Disease

Symptoms:

12
  • abdominal pain
  • headache
  • chills
  • backache
  • regional lymphadenopathy

UMLS symptoms related to Cat-Scratch Disease:


fever, pruritus

Drugs & Therapeutics for Cat-Scratch Disease

Drugs for Cat-Scratch Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4,Phase 3 83905-01-5 447043 55185
3 Hormones Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 glucocorticoids Phase 4
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
7 Hormone Antagonists Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Anti-Infective Agents Phase 3
10 Gentamicins Phase 3
11 Anti-Bacterial Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo

Search NIH Clinical Center for Cat-Scratch Disease

Cochrane evidence based reviews: cat-scratch disease

Genetic Tests for Cat-Scratch Disease

Anatomical Context for Cat-Scratch Disease

MalaCards organs/tissues related to Cat-Scratch Disease:

42
Lymph Node, Skin, Eye, Breast, Bone, Testes, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Cat-Scratch Disease:

20
Lymph Node

Publications for Cat-Scratch Disease

Articles related to Cat-Scratch Disease:

(show top 50) (show all 854)
# Title Authors Year
1
Femoral bone lesions accompanying cat-scratch disease. ( 29572216 )
2019
2
Chest Imaging of a rare case of cat-scratch disease in a 2-years-old baby. ( 30657130 )
2019
3
A CASE OF CAT SCRATCH DISEASE DIAGNOSED BY INDIRECT FLUORESCENT ANTIBODY ASSAY OF IGM SPECIFIC FOR A JAPANESE STRAIN OF Bartonella henselae. ( 30681547 )
2019
4
Serological and molecular detection of Bartonella henselae in specimens from patients with suspected cat scratch disease in Italy: A comparative study. ( 30735549 )
2019
5
First isolation and genotyping of Bartonella henselae from a cat living with a patient with cat scratch disease in Southeast Europe. ( 30940084 )
2019
6
Typical and Atypical 18FDG PET/CT Findings in Two Cases of Cat Scratch Disease. ( 30985438 )
2019
7
The other cat scratch disease. ( 31012431 )
2019
8
Answer to Photo Quiz: The other cat scratch disease. ( 31012432 )
2019
9
Cat scratch disease during etanercept therapy in a rheumatoid arthritis patient. ( 28256443 )
2018
10
Cat Scratch Disease: Not a Benign Condition. ( 28665750 )
2018
11
Cat scratch disease: U.S. clinicians' experience and knowledge. ( 28707827 )
2018
12
A pediatric case with peripheral facial nerve palsy caused by a granulomatous lesion associated with cat scratch disease. ( 28935172 )
2018
13
Utility of Bartonella henselae IgM Western Blot Bands for Serodiagnosis of Cat Scratch Disease. ( 29093103 )
2018
14
Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis. ( 29239936 )
2018
15
Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. ( 29399138 )
2018
16
Cat-scratch disease: ocular manifestations and treatment outcome. ( 29504674 )
2018
17
Encephalopathy in an adult with cat-scratch disease. ( 29507029 )
2018
18
Bartonella henselae DNA in Seronegative Patients with Cat-Scratch Disease. ( 29664374 )
2018
19
Cat scratch disease presenting as axillary lymphadenopathy and a palpable benign mammary nodule mimicking a carcinoma. ( 29768565 )
2018
20
Osteomyelitis in Cat-Scratch Disease: A Never-Ending Dilemma-A Case Report and Literature Review. ( 29808150 )
2018
21
Cat Scratch Disease in a 1.5-year-old girl - Case report. ( 29936799 )
2018
22
Atypical presentation of cat scratch disease: Parinaud's oculoglandular syndrome with facial nerve paresis. ( 29982178 )
2018
23
Clinical and Radiologic Manifestations of Bone Infection in Children with Cat Scratch Disease. ( 30041935 )
2018
24
Cat-Scratch Disease in an AIDS Patient Presenting with Generalized Lymphadenopathy: An Unusual Presentation with Delayed Diagnosis. ( 30068900 )
2018
25
Multifocal pelvic osteomyelitis in a child associated with a cat-scratch disease: a case report and review of the literature. ( 30092749 )
2018
26
Transverse Myelitis and Guillain-Barré Syndrome Associated with Cat-Scratch Disease, Texas, USA, 2011. ( 30124417 )
2018
27
Skull osteomyelitis as a rare complication of cat scratch disease. ( 30319958 )
2018
28
Parinaud's Oculoglandular Syndrome in Cat Scratch Disease. ( 30380392 )
2018
29
Seronegative cat scratch disease in a patient with systemic lupus erythematosus. ( 30414376 )
2018
30
Lymph node syndrome associated with cat scratch disease in children and adults. ( 30441948 )
2018
31
Effectiveness of antibiotic therapy in pediatric patients with cat scratch disease. ( 30446895 )
2018
32
Cat-scratch disease presenting as parotid gland abscess and aseptic meningitis. ( 27426218 )
2017
33
Disseminated cat-scratch disease presenting as nausea, diarrhea, and weight loss without fever in a heart transplant recipient. ( 28199763 )
2017
34
Cat scratch disease. Onset as epithroclear tumor. ( 28416228 )
2017
35
Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease. ( 28669017 )
2017
36
Detection of Bartonella in cat scratch disease using a single-step PCR assay kit. ( 29068281 )
2017
37
Torticollis and Fever in a Young Boy: A Unique Presentation of Cat-Scratch Disease With Vertebral Osteomyelitis and Epidural Phlegmon. ( 29095386 )
2017
38
Cat Scratch Disease During Adalimumab Therapy: A Case Report. ( 29132747 )
2017
39
CAT SCRATCH DISEASE IMITATING A TOXOCARA GRANULOMA OF THE OPTIC DISK. ( 29176527 )
2017
40
Atypical Cat Scratch Disease With Hepatosplenic Involvement. ( 27484614 )
2017
41
Cat-Scratch Disease: A Pitfall for Lymphoma Evaluation by FDG-PET/CT. ( 27997427 )
2017
42
Corticosteroid Treatment for Prolonged Fever in Hepatosplenic Cat-Scratch Disease: A Case Study. ( 28006985 )
2017
43
The utility of a country-specific Bartonella henselae antigen in an IgM-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease. ( 28029424 )
2017
44
Diverse Clinical Signs of Ocular Involvement in Cat Scratch Disease. ( 28182175 )
2017
45
Status Epilepticus Due to Cat Scratch Disease: Recognition, Diagnosis, and Thoughts on Pathogenesis. ( 25853722 )
2016
46
Disseminated cat-scratch disease: case report and review of the literature. ( 25940800 )
2016
47
Cat scratch disease of the parotid gland. ( 26403943 )
2016
48
Cat scratch disease in an immunosuppressed patient with systemic lupus erythematosus. ( 26453661 )
2016
49
Multiple Renal and Splenic Lesions in Cat Scratch Disease. ( 26567841 )
2016
50
Development of a Highly Specific IgM Enzyme-Linked Immunosorbent Assay for Bartonella henselae Using Refined N-Lauroyl-Sarcosine-Insoluble Proteins for Serodiagnosis of Cat Scratch Disease. ( 26865692 )
2016

Variations for Cat-Scratch Disease

Expression for Cat-Scratch Disease

Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for Cat-Scratch Disease

GO Terms for Cat-Scratch Disease

Cellular components related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 8.8 CORO1A EEA1 HSPD1

Biological processes related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic apoptotic signaling pathway GO:0097191 9.26 IFNG TNFRSF1B
2 positive regulation of interleukin-12 production GO:0032735 9.16 HSPD1 IFNG
3 positive regulation of T cell activation GO:0050870 8.96 CORO1A HSPD1
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 IFNG TNFRSF1B

Sources for Cat-Scratch Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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