CTRCT25
MCID: CTR121
MIFTS: 28

Cataract 25 (CTRCT25)

Categories: Eye diseases, Fetal diseases, Genetic diseases, Metabolic diseases, Nephrological diseases, Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Cataract 25

MalaCards integrated aliases for Cataract 25:

Name: Cataract 25 56 12 15
Cataract, Central Saccular, with Sutural Opacities 56 13 71
Ctrct25 56 12
Ccsso 56 12
Cataract, Central Saccular, with Sutural Opacities; Ccsso 56
Cataract, Central Pouch-Like, with Sutural Opacities 56
Early-Onset Cataract with Y-Shaped Suture Opacities 12
Central Pouch-Like Cataract with Sutural Opacities 12
Central Saccular Cataract with Sutural Opacities 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110254
OMIM 56 605728
OMIM Phenotypic Series 56 PS116200
ICD10 32 Q12.0
MedGen 41 C1854021
UMLS 71 C1854021

Summaries for Cataract 25

Disease Ontology : 12 A cataract that has material basis in variation in the region 15q21-q22.

MalaCards based summary : Cataract 25, also known as cataract, central saccular, with sutural opacities, is related to early-onset sutural cataract and cataract. An important gene associated with Cataract 25 is CTRCT25 (Cataract, Central Pouch-Like, With Sutural Opacities), and among its related pathways/superpathways are Pathogenic Escherichia coli infection and Regulation of actin dynamics for phagocytic cup formation. Affiliated tissues include eye.

More information from OMIM: 605728 PS116200

Related Diseases for Cataract 25

Diseases in the Cataract family:

Cataract 32, Multiple Types Cataract 7
Cataract 8, Multiple Types Cataract 4, Multiple Types
Cataract 29 Cataract 42
Cataract 20, Multiple Types Cataract 1, Multiple Types
Cataract 30, Multiple Types Cataract 41
Cataract 6, Multiple Types Cataract 5, Multiple Types
Cataract 46, Juvenile-Onset Cataract 40
Cataract 10, Multiple Types Cataract 24
Cataract 3, Multiple Types Cataract 14, Multiple Types
Cataract 9, Multiple Types Cataract 2, Multiple Types
Cataract 31, Multiple Types Cataract 25
Cataract 26, Multiple Types Cataract 27
Cataract 28 Cataract 35
Cataract 22, Multiple Types Cataract 18
Cataract 21, Multiple Types Cataract 23, Multiple Types
Cataract 11, Multiple Types Cataract 33, Multiple Types
Cataract 17, Multiple Types Cataract 12, Multiple Types
Cataract 47 Cataract 34, Multiple Types
Cataract 16, Multiple Types Cataract 36
Cataract 37 Cataract 38
Cataract 39, Multiple Types Cataract 15, Multiple Types
Cataract 19, Multiple Types Cataract 43
Cataract 44 Cataract 45
Cataract 48 Cataract 30
Cataract 33 Cataract Congenital Autosomal Dominant
Cataract, Total Congenital

Diseases related to Cataract 25 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 11, show less)
# Related Disease Score Top Affiliating Genes
1 early-onset sutural cataract 12.0
2 cataract 11.5
3 albinism, oculocutaneous, type ii 9.9 TUBGCP5 NIPA2
4 barbiturate abuse 9.7 WASF3 WASF1
5 dysthymic disorder 9.6 WASF3 WASF1
6 chromosomal disease 9.5 NIPA2 CYFIP1 BACE1
7 chromosome 15q13.3 deletion syndrome 9.4 NIPA2 NIPA1 IGFBP2
8 angelman syndrome 9.4 TUBGCP5 NIPA2 NIPA1 CYFIP1
9 prader-willi syndrome 9.4 TUBGCP5 NIPA2 NIPA1 CYFIP1
10 oppositional defiant disorder 9.4 WASF3 WASF1
11 chromosome 15q11.2 deletion syndrome 8.2 TUBGCP5 TEF NIPA2 NIPA1 IGFBP2 CYFIP1

Graphical network of the top 20 diseases related to Cataract 25:



Diseases related to Cataract 25

Symptoms & Phenotypes for Cataract 25

Clinical features from OMIM:

605728

Drugs & Therapeutics for Cataract 25

Search Clinical Trials , NIH Clinical Center for Cataract 25

Genetic Tests for Cataract 25

Anatomical Context for Cataract 25

MalaCards organs/tissues related to Cataract 25:

40
Eye

Publications for Cataract 25

Articles related to Cataract 25:

(showing 12, show less)
# Title Authors PMID Year
1
A novel form of "central pouchlike" cataract, with sutural opacities, maps to chromosome 15q21-22. 56
11133359 2001
2
Association of Serum 25-Hydroxyl Vitamin D Deficiency and Age-Related Cataract: A Case-Control Study. 61
31143475 2019
3
Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study. 61
27084082 2016
4
Marfan syndrome in an Iranian family: a case series. 61
25031493 2014
5
Risk of retinal detachment after pediatric cataract surgery. 61
24713483 2014
6
A new central-peripheral corneal curvature method for intraocular lens power calculation after excimer laser refractive surgery. 61
23289447 2013
7
[Vogt-Koyanagi-Harada syndrome. Epidemiological, clinical and disease progression aspects. Twenty cases]. 61
10052048 1998
8
Aetiology of childhood cataract in south India. 61
8795375 1996
9
Causes of visual impairment in central Ethiopia. 61
7588655 1995
10
[Intraocular pressure after filtering operation or combined filter-cataract operation]. 61
7666647 1995
11
[A report of 412 consecutive posterior chamber intraocular lens implantations]. 61
8001442 1994
12
[In vivo autofluorescence. Measurements of human crystalline lenses with cataract and normal findings after excitation with monochromatic light]. 61
1304199 1992

Variations for Cataract 25

Expression for Cataract 25

Search GEO for disease gene expression data for Cataract 25.

Pathways for Cataract 25

GO Terms for Cataract 25

Cellular components related to Cataract 25 according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.13 NIPA2 NIPA1 BACE1
2 SCAR complex GO:0031209 8.62 WASF1 CYFIP1

Biological processes related to Cataract 25 according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 lamellipodium assembly GO:0030032 9.37 WASF3 CYFIP1
2 actin filament polymerization GO:0030041 9.32 WASF3 WASF1
3 Rac protein signal transduction GO:0016601 9.26 WASF1 CYFIP1
4 magnesium ion transmembrane transport GO:1903830 9.16 NIPA2 NIPA1
5 magnesium ion transport GO:0015693 8.96 NIPA2 NIPA1
6 positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601 8.62 WASF1 CYFIP1

Molecular functions related to Cataract 25 according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.33 WASF3 WASF1 CYFIP1
2 Rac GTPase binding GO:0048365 8.96 WASF1 CYFIP1
3 magnesium ion transmembrane transporter activity GO:0015095 8.62 NIPA2 NIPA1

Sources for Cataract 25

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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