CTRCT28
MCID: CTR157
MIFTS: 23

Cataract 28 (CTRCT28)

Categories: Eye diseases, Fetal diseases, Genetic diseases, Metabolic diseases, Nephrological diseases, Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Cataract 28

MalaCards integrated aliases for Cataract 28:

Name: Cataract 28 56 12 15
Cataract, Age-Related Cortical, 1 56 71
Age-Related Cortical Cataract 1 12 13
Ctrct28 56 12
Arcc1 56 12
Cataract 28, Age-Related Cortical, Susceptibility to 56
Cataract, Age-Related Cortical, 1; Arcc1 56
Cataract 28, Age-Related Cortical 56

Classifications:



External Ids:

Disease Ontology 12 DOID:0110244
OMIM 56 609026
OMIM Phenotypic Series 56 PS116200
MedGen 41 C1836942
UMLS 71 C1836942

Summaries for Cataract 28

OMIM : 56 Age-related cataracts are one of the leading causes of visual impairment and blindness among the elderly worldwide. Among age-related cataracts, cortical opacities rank as the second most common type (Iyengar et al., 2004). The preferred title/symbol of this entry was formerly 'Cataract, Age-Related Cortical, 1; ARCC1.' (609026)

MalaCards based summary : Cataract 28, also known as cataract, age-related cortical, 1, is related to cataract and cataract 32, multiple types. An important gene associated with Cataract 28 is CTRCT28 (Cataract 28). Affiliated tissues include eye.

Disease Ontology : 12 A cataract that has material basis in variation in the region 6p12-q12.

Related Diseases for Cataract 28

Diseases in the Cataract family:

Cataract 32, Multiple Types Cataract 7
Cataract 8, Multiple Types Cataract 4, Multiple Types
Cataract 29 Cataract 42
Cataract 20, Multiple Types Cataract 1, Multiple Types
Cataract 30, Multiple Types Cataract 41
Cataract 6, Multiple Types Cataract 5, Multiple Types
Cataract 40 Cataract 10, Multiple Types
Cataract 24 Cataract 3, Multiple Types
Cataract 14, Multiple Types Cataract 9, Multiple Types
Cataract 2, Multiple Types Cataract 31, Multiple Types
Cataract 25 Cataract 26, Multiple Types
Cataract 27 Cataract 28
Cataract 35 Cataract 22, Multiple Types
Cataract 18 Cataract 21, Multiple Types
Cataract 23, Multiple Types Cataract 11, Multiple Types
Cataract 33, Multiple Types Cataract 17, Multiple Types
Cataract 12, Multiple Types Cataract 47
Cataract 34, Multiple Types Cataract 16, Multiple Types
Cataract 36 Cataract 37
Cataract 38 Cataract 39, Multiple Types
Cataract 15, Multiple Types Cataract 19, Multiple Types
Cataract 43 Cataract 44
Cataract 45 Cataract 48
Cataract 30 Cataract 33
Cataract Congenital Autosomal Dominant Cataract, Total Congenital

Diseases related to Cataract 28 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cataract 30.3 TMEM114 SLC16A12 LIM2 CTRCT28 CRYAA
2 cataract 32, multiple types 9.9 TMEM114 CRYAA
3 cataract 16, multiple types 9.9 TMEM114 CRYAA
4 triosephosphate isomerase deficiency 9.9 TPI1 CRYAA
5 salivary gland disease 9.6 TPI1 GUK1
6 cataract 44 9.6 LIM2 CRYAA
7 cataract 6, multiple types 9.5 TMEM114 GUK1 CRYAA ARCN1
8 galactosemia ii 8.9 TMEM114 SLC16A12 LIM2 CRYAA
9 axenfeld-rieger syndrome, type 3 8.9 TMEM114 SLC16A12 LIM2 CRYAA

Graphical network of the top 20 diseases related to Cataract 28:



Diseases related to Cataract 28

Symptoms & Phenotypes for Cataract 28

Clinical features from OMIM:

609026

Drugs & Therapeutics for Cataract 28

Search Clinical Trials , NIH Clinical Center for Cataract 28

Genetic Tests for Cataract 28

Anatomical Context for Cataract 28

MalaCards organs/tissues related to Cataract 28:

40
Eye

Publications for Cataract 28

Articles related to Cataract 28:

(show all 12)
# Title Authors PMID Year
1
Statin use and the long-term risk of incident cataract: the Blue Mountains Eye Study. 56
17386279 2007
2
Cortical, but not posterior subcapsular, cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors. 56
15629823 2005
3
Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. 56
15452352 2004
4
Prevalence and Predictors of Ocular Complications in Obstructive Sleep Apnea Patients: A Cross-sectional Case-control Study. 61
31908685 2019
5
[Study of vitreomacular interface in patients with pseudophakia by means of spectral optical coherence tomography]. 61
27600894 2016
6
Predictors of damage and survival in patients with Wegener's granulomatosis: analysis of 50 patients. 61
20008921 2010
7
[Causes of visual loss in uveitis]. 61
19877547 2009
8
Long-term results of low-dose proton beam therapy for circumscribed choroidal hemangiomas. 61
18997642 2009
9
[Effects of matrix metalloproteinase-3, osteopontin, and tissue inhibitor of metalloproteinase-1 in the formation of cataract]. 61
17062942 2006
10
[A study on the treatment of secondary glaucoma due to intumescent senile cataract]. 61
11770405 2001
11
[The effect of the pseudoexfoliative syndrome on the evolution and treatment of pseudoexfoliative glaucoma and senile cataract]. 61
8962851 1996
12
Ophthalmic complications following megavoltage irradiation of the nasal and paranasal cavities in dogs. 61
3102420 1987

Variations for Cataract 28

Expression for Cataract 28

Search GEO for disease gene expression data for Cataract 28.

Pathways for Cataract 28

GO Terms for Cataract 28

Biological processes related to Cataract 28 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retrograde vesicle-mediated transport, Golgi to ER GO:0006890 8.62 KLC1 ARCN1

Molecular functions related to Cataract 28 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.62 LIM2 CRYAA

Sources for Cataract 28

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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