MCID: CTR176
MIFTS: 15

Cataract, Age-Related Nuclear

Categories: Eye diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Cataract, Age-Related Nuclear

MalaCards integrated aliases for Cataract, Age-Related Nuclear:

Name: Cataract, Age-Related Nuclear 56 71
Nuclear Sclerosis of the Lens 56

Characteristics:

OMIM:

56
Inheritance:
autosomal recessive gene accounts for 35% of variability


HPO:

31
cataract, age-related nuclear:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 56 601371
MedGen 41 C1832423
SNOMED-CT via HPO 68 258211005 53889007
UMLS 71 C1832423

Summaries for Cataract, Age-Related Nuclear

MalaCards based summary : Cataract, Age-Related Nuclear, also known as nuclear sclerosis of the lens, is related to cataract. The drug Dipivefrin has been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is nuclear cataract.

More information from OMIM: 601371

Related Diseases for Cataract, Age-Related Nuclear

Diseases in the Early-Onset Nuclear Cataract family:

Cataract, Age-Related Nuclear Autosomal Recessive Nonsyndromic Congenital Nuclear Cataract

Diseases related to Cataract, Age-Related Nuclear via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cataract 10.0

Symptoms & Phenotypes for Cataract, Age-Related Nuclear

Human phenotypes related to Cataract, Age-Related Nuclear:

31
# Description HPO Frequency HPO Source Accession
1 nuclear cataract 31 HP:0100018

Symptoms via clinical synopsis from OMIM:

56
Eyes:
nuclear sclerosis of the lens

Clinical features from OMIM:

601371

Drugs & Therapeutics for Cataract, Age-Related Nuclear

Drugs for Cataract, Age-Related Nuclear (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved 52365-63-6 3105

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Krypton-Argon Regression of Neovascularization Study (KARNS) Completed NCT00000153 Phase 3
2 A Prospective Randomized Controlled Clinical Trial Comparing the Intra-operative Effects, Safety, Efficacy and Performance of Two Commercially Available Laser Systems in Patients Undergoing Femtosecond Laser-Assisted Cataract Surgery. Completed NCT01878838

Search NIH Clinical Center for Cataract, Age-Related Nuclear

Genetic Tests for Cataract, Age-Related Nuclear

Anatomical Context for Cataract, Age-Related Nuclear

MalaCards organs/tissues related to Cataract, Age-Related Nuclear:

40
Eye

Publications for Cataract, Age-Related Nuclear

Articles related to Cataract, Age-Related Nuclear:

# Title Authors PMID Year
1
Statin use and the long-term risk of incident cataract: the Blue Mountains Eye Study. 56
17386279 2007
2
Statin use and incident nuclear cataract. 56
16788130 2006
3
Genetic etiology of nuclear cataract: evidence for a major gene. 56
8291558 1993
4
Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes. 61
19854833 2009
5
Inhibition of crystallin ascorbylation by nucleophilic compounds in the hSVCT2 mouse model of lenticular aging. 61
18421088 2008
6
Copper foreign body in the lens without damage of iris and lens capsule. 61
17503000 2007
7
[Pars plana vitrectomy for idiopathic vitreous floaters]. 61
16175483 2005
8
"Glaucoma affecting each crystalline lens": a long-lost manuscript by Dr. William Mackenzie. 61
10906384 2000
9
Histopathological findings of X-linked retinoschisis with neovascular glaucoma. 61
10664045 2000
10
Phacoemulsification and intraocular lens implantation in a patient with Mooren's ulcer. 61
9304642 1997

Variations for Cataract, Age-Related Nuclear

Expression for Cataract, Age-Related Nuclear

Search GEO for disease gene expression data for Cataract, Age-Related Nuclear.

Pathways for Cataract, Age-Related Nuclear

GO Terms for Cataract, Age-Related Nuclear

Sources for Cataract, Age-Related Nuclear

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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