Categories: Eye diseases, Rare diseases

Aliases & Classifications for Cataract-Glaucoma

MalaCards integrated aliases for Cataract-Glaucoma:

Name: Cataract-Glaucoma 52
Cataract-Glaucoma Syndrome 58


Orphanet epidemiological data:

cataract-glaucoma syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal;


MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases

External Ids:

ICD10 via Orphanet 33 Q12.0
Orphanet 58 ORPHA162

Summaries for Cataract-Glaucoma

MalaCards based summary : Cataract-Glaucoma, also known as cataract-glaucoma syndrome, is related to cataract and persistent hyperplastic primary vitreous, autosomal recessive. An important gene associated with Cataract-Glaucoma is PITX3 (Paired Like Homeodomain 3). The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cataract-Glaucoma

Graphical network of the top 20 diseases related to Cataract-Glaucoma:

Diseases related to Cataract-Glaucoma

Symptoms & Phenotypes for Cataract-Glaucoma

GenomeRNAi Phenotypes related to Cataract-Glaucoma according to GeneCards Suite gene sharing:

26 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.91 PITX3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.91 ATOH7
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 9.91 ATOH7
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-172 9.91 PITX3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.91 PITX3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.91 OCRL
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.91 PITX3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.91 PITX3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.91 ATOH7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.91 OCRL ATOH7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.91 OCRL PITX3
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.91 OCRL
13 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.6 ATOH7 PITX3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.6 ATOH7
15 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.6 PITX3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.6 PITX3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 PITX3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.6 ATOH7
19 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.6 PITX3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.6 ATOH7
21 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.6 PITX3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.6 PITX3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.6 ATOH7
24 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.6 PITX3
25 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 PITX3
26 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.6 ATOH7 PITX3
27 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.6 PITX3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.6 PITX3
29 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.6 PITX3

MGI Mouse Phenotypes related to Cataract-Glaucoma:

# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 ATOH7 OCRL PITX3
2 vision/eye MP:0005391 8.8 ATOH7 OCRL PITX3

Drugs & Therapeutics for Cataract-Glaucoma

Drugs for Cataract-Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
Ofloxacin Approved Phase 4 82419-36-1 4583
3 Antibiotics, Antitubercular Phase 4
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Renal Agents Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Topoisomerase Inhibitors Phase 4
9 Anti-Infective Agents, Urinary Phase 4
10 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
11 Ophthalmic Solutions Phase 4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
15 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
Pilocarpine Approved, Investigational Phase 3 92-13-7, 54-71-7 5910
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
19 Neurotransmitter Agents Phase 3
20 Anti-Inflammatory Agents Phase 3
21 Hormone Antagonists Phase 3
22 Autonomic Agents Phase 3
23 glucocorticoids Phase 3
24 Hormones Phase 3
25 Protective Agents Phase 3
26 Antiemetics Phase 3
27 Methylprednisolone Acetate Phase 3
28 Neuroprotective Agents Phase 3
29 Gastrointestinal Agents Phase 3
30 Antineoplastic Agents, Hormonal Phase 3
31 Muscarinic Agonists Phase 3
32 Cholinergic Agents Phase 3
33 Pharmaceutical Solutions Phase 3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
35 Endothelial Growth Factors Phase 2
36 Angiogenesis Inhibitors Phase 2
37 Antineoplastic Agents, Immunological Phase 2
38 Mitogens Phase 2
39 Melanocyte-Stimulating Hormones Phase 2
40 beta-endorphin Phase 2
41 Adrenocorticotropic Hormone Phase 2
42 Endorphins Phase 2
Hyaluronic acid Approved, Vet_approved Phase 1 9004-61-9 53477741
44 Adjuvants, Immunologic Phase 1
45 Viscosupplements Phase 1
46 Immunologic Factors Phase 1
Fluticasone Approved, Experimental 90566-53-3 62924
48 Castor
49 Sympathomimetics
50 Adrenergic Agonists

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Combined Phacoemulsification and Glaucoma Implant Surgery Versus Combined Phacoemulsification and Trabeculectomy: A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
2 A Study of the Glaukos Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. Completed NCT00326014 Phase 4
3 A Comparison of Three Different Formulations of Topical Prednisolone Acetate 1% for Control of Post Glaucoma and/or Cataract Surgery Inflammation. Completed NCT00345046 Phase 4 Pred Forte;EconoPred Plus;Prednisolone Acetate
4 Phase 4 Study on Effectiveness of Topical 0.5% Levofloxacin on Reduction of Preoperative Conjunctival Flora in Patients Scheduled for Intraocular Surgery Completed NCT00491049 Phase 4 0.5% levofloxacin eye drops
5 A Prospective, Controlled, Multicenter Post-Approval Study Of The Glaukos® iStent® Trabecular Micro-Bypass Stent System In Conjunction With Cataract Surgery Active, not recruiting NCT01841450 Phase 4
6 A Prospective Evaluation of Mild to Moderate Open-Angle Glaucoma Subjects With Cataract Treated With Cataract Surgery Plus One Trabecular Micro-bypass Stent and One Suprachoroidal Stent Not yet recruiting NCT03255785 Phase 4
7 A Study of the Glaukos Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. Completed NCT00323284 Phase 3
8 A Prospective, Randomized, Controlled, Parallel Groupos, Multicenter Clinical Investigation of the Glaukos Trabecular Micro-bypass Stent Model GTS400 in Conjunction With Cataract Surgery Completed NCT01052558 Phase 3
9 A Prospective, Randomized, Controlled, Parallel Groups, Multicenter Clinical Investigation Of The Trabecular Micro-Bypass Stent Model GTS400 In Conjunction With Cataract Surgery Completed NCT00721968 Phase 3
10 A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Trabectome Surgery Recruiting NCT04005079 Phase 3 Pilocarpine;Ofloxacin;Prednisolone
11 A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Kahook Dual Blade Surgery Enrolling by invitation NCT03933631 Phase 3 Pilocarpine;Prednisolone;Ofloxacin
12 A Prospective, Multi-Center Evaluation of the Hydrus Aqueous Implant (Standard and Low-Profile) for Lowering Intraocular Pressure (IOP) in Subjects With Mild to Advanced Primary Open Angle Glaucoma (POAG) With or Without a Cataract Completed NCT03065036 Phase 1, Phase 2 prestudy topical glaucoma medications
13 Evaluation of the Pain and Visual Outcome Associated With Location of Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
14 An Open Label, Multi-centered, Randomized Phase 2 Study to Evaluate the Safety, Tolerability and Bioactivity of Subcutaneous ACTH GeL in PAtients With Scleritis: The ATLAS Study Recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
15 An Open Two-center Study Evaluating the Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy in Patients With Open Angle Glaucoma and Cataract Completed NCT01887873 Phase 1
16 Comparison of Safety and Efficacy of Three Variants of Canaloplasty: Ab-externo, Ab-interno and Minicanaloplasty Combined With Phacoemulsification to Treat Glaucoma and Cataract. A Randomised, Prospective Study. Unknown status NCT02908633
17 Outcome of Small Pupil Phacotrabeculectomy in Persons With Glaucoma and Cataract Unknown status NCT00434707
18 To Check the Efficacy and Saftey of Combined Ex-PRESS Implantation Alone or With Phacoemulsification for Glaucoma Associated With Cataract Unknown status NCT02209961
19 Frequency Of Eye Problems In Type 2 Diabetes With Chronic Kidney Disease Unknown status NCT03330054
20 Comparison of Safety and Efficacy of Canaloplasty and Non-penetrating Deep Sclerectomy Combined With Phacoemulsification to Treat Glaucoma and Cataract. A Randomised, Prospective Study. Unknown status NCT01726543
21 To Compare Visual Field Impairment in Conventional Double Frequency Nd: YAG Panretinal Photocoagulation With PASCAL Panretinal Photocoagulation Unknown status NCT01023113
22 Glaukos® iStent® Trabecular Micro-Bypass Stent System In Conjunction With Cataract Surgery Postmarket Registry Completed NCT01841437
23 Special Drug Use Investigation for ADOAIR Metered-dose Inhaler (Pediatric) Completed NCT01332422 Salmeterol and Fluticasone
24 Effectiveness of Selective Laser Trabeculoplasty (SLT) After Failed Phacoemulsification Cataract Extraction Combined With Eximer Laser Trabeculectomy (Phaco-ELT) in Open Angle Glaucoma and Ocular Hypertension Completed NCT02434250
25 A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Newly Diagnosed Open Angle Glaucoma and Subjects Diagnosed With Ocular Hypertension Completed NCT00326066
26 A Prospective, Multi-Center, Randomized Controlled Trial to Evaluate the Safety and Effectiveness of the Hydrus Implant for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery. Completed NCT01818115
27 Comparison of Combined Phacotrabeculectomy and Trabeculectomy Only in the Treatment of Primary Angle-closure Glaucoma Completed NCT01298635
28 A Prospective, Multicenter, Randomized Comparison of the Hydrus Microstent to the iStent for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery Completed NCT02024464
29 Comparison Between OCT Nerve Fiber Layer and Ganglion Cell Complex Parameters Following Cataract Extraction in Patients With or Without Primary Open Angle Glaucoma Completed NCT03889652
30 A Prospective, Randomized, Comparative, MultiCenter Clinical Study to Assess the Safety and Effectiveness of the Transcend CyPass Glaucoma Implant in Patients With Open Angle Glaucoma Undergoing Cataract Surgery Completed NCT01085357
31 Study of the Safety and Effectiveness of the OculusGenTM Collagen Matrix Implant as an Aid in Phacotrabeculectomy Surgery Completed NCT00477685
32 Longtime Efficiency of Combined Cataract-Surgery and Excimer-Laser-Trabeculotomy or Trabectome in Glaucoma Surgery Completed NCT01194310
33 A Novel Prophylactic Peripheral Iridectomy Prevents Aphakic Angle-closure Glaucoma After Congenital Cataract Surgery Completed NCT03610295
34 Antibiotic Susceptibility of Conjunctival Bacterial Isolates From Refractive Surgery Patients Completed NCT00707005
35 Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy Completed NCT00695747
36 Autoimmune Dysregulation in Pigmentary Glaucoma Completed NCT00280345
37 A Randomized, Double-Masked Clinical Trial of Phacoemulsification Compared With Phacoemulsification and Micro-Bypass Stent Implantation in Patients With POAG Completed NCT00847158
38 Lower Femtosecond Laser Energy Levels Lead to Better Visual Recovery After Small-incision Lenticule Extraction for Myopia Completed NCT03111160
39 Prospective, Multi‐Center, Post‐Market Study of Use of the OMNI® Surgical System in Combination With Cataract Extraction in Open Angle Glaucoma Recruiting NCT03861169
40 A Randomised Controlled Trial of Cataract Surgery Versus Combined Cataract Surgery With Insertion of iStent Inject® Recruiting NCT03106181
41 Lncidence of Sub-clinical Cystoid Macular Edema After Cataract Surgery Recruiting NCT04161963
42 Evaluation of the Xen Implant in Glaucoma Surgery Recruiting NCT03733600
43 A Double-masked, Randomized, Cross-over Comparative Study of Novel Myopia Control Designed Lens (Test Lens) Versus Single Vision Lens (SVL; Control) Recruiting NCT04048148
44 Anterior Segment Changes Before and After Uneventful Combined Phaco-Trabeculectomy by Using Optical Coherence Tomography (OCT) Recruiting NCT03626675
45 A Prospective Evaluation of Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery Active, not recruiting NCT01455467
46 A Prospective, Randomized, Single-Masked, Controlled, Parallel Groups, Multicenter Clinical Investigation of the Glaukos® Trabecular Micro-Bypass Stent Model GTS400 Using the G2-M-IS Injector System in Conjunction With Cataract Surgery Active, not recruiting NCT01461291
47 A Prospective, Randomized, Single-Masked, Controlled, Parallel Groups, Multicenter Clinical Investigation of the Glaukos® Suprachoroidal Stent Model G3 In Conjunction With Cataract Surgery Active, not recruiting NCT01461278
48 A Prospective, Randomized, Multi-Center, Open-Label Trial Comparing a Novel Goniotomy Procedure and an Ab Interno Trabecular Bypass Device in the Treatment of Mild to Moderate Glaucoma in Patients Undergoing Cataract Extraction Active, not recruiting NCT02784249
49 The Safety and Effectiveness of the Hydrus Aqueous Implant for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery, A Prospective, Multicenter, Randomized, Controlled Clinical Trial Active, not recruiting NCT01539239
50 Post Approval Study of the CyPass System in Patients With Primary Open Angle Glaucoma Undergoing Cataract Surgery Active, not recruiting NCT03273907

Search NIH Clinical Center for Cataract-Glaucoma

Genetic Tests for Cataract-Glaucoma

Anatomical Context for Cataract-Glaucoma

MalaCards organs/tissues related to Cataract-Glaucoma:

Eye, Testes, Kidney, Endothelial

Publications for Cataract-Glaucoma

Articles related to Cataract-Glaucoma:

(show top 50) (show all 356)
# Title Authors PMID Year
Epidemiology of Congenital Rubella Syndrome (CRS) in India, 2016-18, based on data from sentinel surveillance. 61
32012162 2020
Automated extraction of ophthalmic surgery outcomes from the electronic health record. 61
31706228 2020
Wireless, passive strain sensor in a doughnut-shaped contact lens for continuous non-invasive self-monitoring of intraocular pressure. 61
31825423 2020
NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy. 61
32019187 2020
Long-term outcomes of penetrating keratoplasty for corneal complications of herpes zoster ophthalmicus. 61
30733209 2019
Biallelic Deletion of Pxdn in Mice Leads to Anophthalmia and Severe Eye Malformation. 61
31817535 2019
Hypotonia and delayed motor development as an early presentation of Lowe syndrome: case report and literature review. 61
30501482 2019
One-Year Outcomes of Second-Generation Trabecular Micro-Bypass Stents (iStent Inject) Implantation with Cataract Surgery in Different Glaucoma Subtypes and Severities. 61
31538316 2019
Relationship between refractive correction, visual symptoms, and optical device selection for low-vision patients in Taiwan. 61
31787520 2019
Complications and adverse events of plaque brachytherapy for ocular melanoma. 61
31523242 2019
Impact of Visual Impairment and Blindness on Quality of Life of Patients in Owerri, Imo State, Nigeria. 61
31619898 2019
Perioperative considerations and anesthesia management in patients with obstructive sleep apnea undergoing ophthalmic surgery. 61
31174989 2019
Relationships between Hearing Loss and the Prevalences of Cataract, Glaucoma, Diabetic Retinopathy, and Age-Related Macular Degeneration in Korea. 61
31336642 2019
Frequency of Ocular Diseases in Infants at a Tertiary Care Hospital. 61
31179661 2019
[Perioperative Anti-inflammatory Treatment in Glaucoma Surgery]. 61
31096283 2019
A rare cause of familial exogenous Cushing syndrome. 61
31198763 2019
Patient-oriented mobile applications in ophthalmology. 61
30168194 2019
Circular RNAs: Novel Promising Biomarkers in Ocular Diseases. 61
31171902 2019
Outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing, a 16-year experience. 61
31496763 2019
Anterior chamber angle in aniridia with and without glaucoma. 61
31496636 2019
[Features of the course of anterior uveitis associated with HLA-B27 antigen]. 61
31691649 2019
Magrabi ICO Cameroon Eye Institute, Yaoundé, Cameroon: Ophthalmology Subspecialty Patient Care and Training Center in Central Africa. 61
30240727 2019
Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases. 61
30891116 2019
Pattern of Childhood Uveitis in Egypt. 61
30148647 2019
The use of patient-reported outcome research in modern ophthalmology: impact on clinical trials and routine clinical practice. 61
30774489 2019
[Who visits an ophthalmologist and how often? Results of the German nationwide adult health survey (DEGS1)]. 61
29110124 2018
Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders. 61
30591791 2018
Evaluation of content and cost of traditional eye medication in a resource-poor country - Implications for eye care practice and policy. 61
30417853 2018
Prevalence and associated factors of low vision and blindness among patients attending St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. 61
30176841 2018
Three-dimensional tubule formation assay as therapeutic screening model for ocular microvascular disorders. 61
29743587 2018
Ultraviolet radiation oxidative stress affects eye health. 61
29603665 2018
Comparison of outcomes and complications of deep anterior lamellar keratoplasty and penetrating keratoplasty performed in a large group of patients with keratoconus. 61
28534231 2018
Regenerating Eye Tissues to Preserve and Restore Vision. 61
29859174 2018
Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis. 61
29699563 2018
Burden of vision loss associated with eye disease in China 1990-2020: findings from the Global Burden of Disease Study 2015. 61
28607177 2018
Projection of Eye Disease Burden in Singapore. 61
29493707 2018
Ophthalmological finding in a patient with lowe syndrome. 61
30650973 2018
Prevalence of visual impairment and related factors in Nangarhar Province of Afghanistan: a cross sectional study. 61
30588432 2018
Clinical Characteristics of Wolfram Syndrome in Chinese Population and a Novel Frameshift Mutation in WFS1. 61
29483894 2018
Which dose of bevacizumab is more effective for the treatment of aggressive posterior retinopathy of prematurity: lower or higher dose? 61
29538588 2018
Comparison of success rates in eye drop instillation between sitting position and supine position. 61
30235323 2018
Public awareness of common eye diseases in Jordan. 61
28969614 2017
The role and therapeutic potential of melatonin in age-related ocular diseases. 61
28658514 2017
Clinical Spectrum of HLA-B27-associated Ocular Inflammation. 61
27428361 2017
Clinical Features and Prognostic Factors in Presumed Ocular Tuberculosis. 61
28157425 2017
The association between nuclear receptors and ocular diseases. 61
28187442 2017
Therapeutic targets of renin-angiotensin system in ocular disorders. 61
28367520 2017
Smartphones, tele-ophthalmology, and VISION 2020. 61
29259912 2017
Timed up and go test combined with self-rated multifactorial questionnaire on falls risk and sociodemographic factors predicts falls among community-dwelling older adults better than the timed up and go test on its own. 61
29138571 2017
Prevalence of diagnosed ocular disease in veterans with serious mental illness. 61
27796250 2016

Variations for Cataract-Glaucoma

Expression for Cataract-Glaucoma

Search GEO for disease gene expression data for Cataract-Glaucoma.

Pathways for Cataract-Glaucoma

GO Terms for Cataract-Glaucoma

Sources for Cataract-Glaucoma

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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