MCID: CTR027
MIFTS: 28

Cataract-Glaucoma

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Cataract-Glaucoma

MalaCards integrated aliases for Cataract-Glaucoma:

Name: Cataract-Glaucoma 53
Cataract-Glaucoma Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
cataract-glaucoma syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

ICD10 via Orphanet 34 Q12.0
Orphanet 59 ORPHA162

Summaries for Cataract-Glaucoma

MalaCards based summary : Cataract-Glaucoma, also known as cataract-glaucoma syndrome, is related to cataract and persistent hyperplastic primary vitreous, autosomal recessive. An important gene associated with Cataract-Glaucoma is PITX3 (Paired Like Homeodomain 3). The drugs Ofloxacin and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and kidney, and related phenotypes are reproductive system and vision/eye

Related Diseases for Cataract-Glaucoma

Graphical network of the top 20 diseases related to Cataract-Glaucoma:



Diseases related to Cataract-Glaucoma

Symptoms & Phenotypes for Cataract-Glaucoma

MGI Mouse Phenotypes related to Cataract-Glaucoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 ATOH7 OCRL PITX3
2 vision/eye MP:0005391 8.8 ATOH7 OCRL PITX3

Drugs & Therapeutics for Cataract-Glaucoma

Drugs for Cataract-Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ofloxacin Approved Phase 4 82419-36-1 4583
2
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
3 Antibiotics, Antitubercular Phase 4
4 Anti-Infective Agents Phase 4
5 Anti-Bacterial Agents Phase 4
6 Renal Agents Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Ophthalmic Solutions Phase 4
9 Topoisomerase Inhibitors Phase 4
10 Anti-Infective Agents, Urinary Phase 4
11 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
12
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
13
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
14
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
16
Pilocarpine Approved, Investigational Phase 3 92-13-7, 54-71-7 5910
17
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
18 Neurotransmitter Agents Phase 3
19 Anti-Inflammatory Agents Phase 3
20 glucocorticoids Phase 3
21 Peripheral Nervous System Agents Phase 3
22 Autonomic Agents Phase 3
23 Protective Agents Phase 3
24 Antiemetics Phase 3
25 Gastrointestinal Agents Phase 3
26 Neuroprotective Agents Phase 3
27 Methylprednisolone Acetate Phase 3
28 Antineoplastic Agents, Hormonal Phase 3
29 Prednisolone acetate Phase 3
30 Pharmaceutical Solutions Phase 3
31 Cholinergic Agents Phase 3
32 Muscarinic Agonists Phase 3
33
Bevacizumab Approved, Investigational Phase 2 216974-75-3
34 Angiogenesis Inhibitors Phase 2
35 Mitogens Phase 2
36 Angiogenesis Modulating Agents Phase 2
37 Antineoplastic Agents, Immunological Phase 2
38 Endothelial Growth Factors Phase 2
39 Hormone Antagonists Phase 2
40 Hormones Phase 2
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
42 Adrenocorticotropic Hormone Phase 2
43 beta-endorphin Phase 2
44 Melanocyte-Stimulating Hormones Phase 2
45 Endorphins Phase 2
46
Hyaluronic acid Approved, Vet_approved Phase 1 9004-61-9 53477741
47 Adjuvants, Immunologic Phase 1
48 Immunologic Factors Phase 1
49 Viscosupplements Phase 1
50
Fluticasone Approved, Experimental 90566-53-3 62924

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Combined Phacoemulsification and Glaucoma Implant Surgery Versus Combined Phacoemulsification and Trabeculectomy: A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
2 A Study of the Glaukos Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. Completed NCT00326014 Phase 4
3 A Comparison of Three Different Formulations of Topical Prednisolone Acetate 1% for Control of Post Glaucoma and/or Cataract Surgery Inflammation. Completed NCT00345046 Phase 4 Pred Forte;EconoPred Plus;Prednisolone Acetate
4 Phase 4 Study on Effectiveness of Topical 0.5% Levofloxacin on Reduction of Preoperative Conjunctival Flora in Patients Scheduled for Intraocular Surgery Completed NCT00491049 Phase 4 0.5% levofloxacin eye drops
5 A Prospective, Controlled, Multicenter Post-Approval Study Of The Glaukos® iStent® Trabecular Micro-Bypass Stent System In Conjunction With Cataract Surgery Active, not recruiting NCT01841450 Phase 4
6 A Prospective Evaluation of Mild to Moderate Open-Angle Glaucoma Subjects With Cataract Treated With Cataract Surgery Plus One Trabecular Micro-bypass Stent and One Suprachoroidal Stent Not yet recruiting NCT03255785 Phase 4
7 A Study of the Glaukos Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. Completed NCT00323284 Phase 3
8 A Prospective, Randomized, Controlled, Parallel Groups, Multicenter Clinical Investigation Of The Trabecular Micro-Bypass Stent Model GTS400 In Conjunction With Cataract Surgery Completed NCT00721968 Phase 3
9 A Prospective, Randomized, Controlled, Parallel Groupos, Multicenter Clinical Investigation of the Glaukos Trabecular Micro-bypass Stent Model GTS400 in Conjunction With Cataract Surgery Completed NCT01052558 Phase 3
10 A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Kahook Dual Blade Surgery Recruiting NCT03933631 Phase 3 Pilocarpine;Prednisolone;Ofloxacin
11 A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Trabectome Surgery Recruiting NCT04005079 Phase 3 Pilocarpine;Ofloxacin;Prednisolone
12 A Prospective, Multi-Center Evaluation of the Hydrus Aqueous Implant (Standard and Low-Profile) for Lowering Intraocular Pressure (IOP) in Subjects With Mild to Advanced Primary Open Angle Glaucoma (POAG) With or Without a Cataract Completed NCT03065036 Phase 1, Phase 2 prestudy topical glaucoma medications
13 Evaluation of the Pain and Visual Outcome Associated With Location of Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
14 An Open Label, Multi-centered, Randomized Phase 2 Study to Evaluate the Safety, Tolerability and Bioactivity of Subcutaneous ACTH GeL in PAtients With Scleritis: The ATLAS Study Recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
15 An Open Two-center Study Evaluating the Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy in Patients With Open Angle Glaucoma and Cataract Completed NCT01887873 Phase 1
16 Outcome of Small Pupil Phacotrabeculectomy in Persons With Glaucoma and Cataract Unknown status NCT00434707
17 To Check the Efficacy and Saftey of Combined Ex-PRESS Implantation Alone or With Phacoemulsification for Glaucoma Associated With Cataract Unknown status NCT02209961
18 Comparison of Safety and Efficacy of Canaloplasty and Non-penetrating Deep Sclerectomy Combined With Phacoemulsification to Treat Glaucoma and Cataract. A Randomised, Prospective Study. Unknown status NCT01726543
19 To Compare Visual Field Impairment in Conventional Double Frequency Nd: YAG Panretinal Photocoagulation With PASCAL Panretinal Photocoagulation Unknown status NCT01023113
20 Glaukos® iStent® Trabecular Micro-Bypass Stent System In Conjunction With Cataract Surgery Postmarket Registry Completed NCT01841437
21 Special Drug Use Investigation for ADOAIR Metered-dose Inhaler (Pediatric) Completed NCT01332422 Salmeterol and Fluticasone
22 Effectiveness of Selective Laser Trabeculoplasty (SLT) After Failed Phacoemulsification Cataract Extraction Combined With Eximer Laser Trabeculectomy (Phaco-ELT) in Open Angle Glaucoma and Ocular Hypertension Completed NCT02434250
23 A Prospective, Multi-Center, Randomized Controlled Trial to Evaluate the Safety and Effectiveness of the Hydrus Implant for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery. Completed NCT01818115
24 A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Newly Diagnosed Open Angle Glaucoma and Subjects Diagnosed With Ocular Hypertension Completed NCT00326066
25 Comparison of Combined Phacotrabeculectomy and Trabeculectomy Only in the Treatment of Primary Angle-closure Glaucoma Completed NCT01298635
26 Comparison Between OCT Nerve Fiber Layer and Ganglion Cell Complex Parameters Following Cataract Extraction in Patients With or Without Primary Open Angle Glaucoma Completed NCT03889652
27 Study of the Safety and Effectiveness of the OculusGenTM Collagen Matrix Implant as an Aid in Phacotrabeculectomy Surgery Completed NCT00477685
28 Longtime Efficiency of Combined Cataract-Surgery and Excimer-Laser-Trabeculotomy or Trabectome in Glaucoma Surgery Completed NCT01194310
29 A Prospective, Randomized, Comparative, MultiCenter Clinical Study to Assess the Safety and Effectiveness of the Transcend CyPass Glaucoma Implant in Patients With Open Angle Glaucoma Undergoing Cataract Surgery Completed NCT01085357
30 A Novel Prophylactic Peripheral Iridectomy Prevents Aphakic Angle-closure Glaucoma After Congenital Cataract Surgery Completed NCT03610295
31 Antibiotic Susceptibility of Conjunctival Bacterial Isolates From Refractive Surgery Patients Completed NCT00707005
32 Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy Completed NCT00695747
33 Autoimmune Dysregulation in Pigmentary Glaucoma Completed NCT00280345
34 A Randomized, Double-Masked Clinical Trial of Phacoemulsification Compared With Phacoemulsification and Micro-Bypass Stent Implantation in Patients With POAG Completed NCT00847158
35 Lower Femtosecond Laser Energy Levels Lead to Better Visual Recovery After Small-incision Lenticule Extraction for Myopia Completed NCT03111160
36 Comparison of Safety and Efficacy of Three Variants of Canaloplasty: Ab-externo, Ab-interno and Minicanaloplasty Combined With Phacoemulsification to Treat Glaucoma and Cataract. A Randomised, Prospective Study. Recruiting NCT02908633
37 Prospective, Multi‐Center, Post‐Market Study of Use of the OMNI® Surgical System in Combination With Cataract Extraction in Open Angle Glaucoma Recruiting NCT03861169
38 A Randomised Controlled Trial of Cataract Surgery Versus Combined Cataract Surgery With Insertion of iStent Inject® Recruiting NCT03106181
39 Evaluation of the Xen Implant in Glaucoma Surgery Recruiting NCT03733600
40 A Double-masked, Randomized, Cross-over Comparative Study of Novel Myopia Control Designed Lens (Test Lens) Versus Single Vision Lens (SVL; Control) Recruiting NCT04048148
41 Anterior Segment Changes Before and After Uneventful Combined Phaco-Trabeculectomy by Using Optical Coherence Tomography (OCT) Recruiting NCT03626675
42 A Prospective Evaluation of Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery Active, not recruiting NCT01455467
43 A Prospective, Randomized, Single-Masked, Controlled, Parallel Groups, Multicenter Clinical Investigation of the Glaukos® Trabecular Micro-Bypass Stent Model GTS400 Using the G2-M-IS Injector System in Conjunction With Cataract Surgery Active, not recruiting NCT01461291
44 A Prospective, Randomized, Single-Masked, Controlled, Parallel Groups, Multicenter Clinical Investigation of the Glaukos® Suprachoroidal Stent Model G3 In Conjunction With Cataract Surgery Active, not recruiting NCT01461278
45 A Prospective, Randomized, Multi-Center, Open-Label Trial Comparing a Novel Goniotomy Procedure and an Ab Interno Trabecular Bypass Device in the Treatment of Mild to Moderate Glaucoma in Patients Undergoing Cataract Extraction Active, not recruiting NCT02784249
46 A Prospective, Multicenter, Randomized Comparison of the Hydrus Microstent to the iStent for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery Active, not recruiting NCT02024464
47 The Safety and Effectiveness of the Hydrus Aqueous Implant for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery, A Prospective, Multicenter, Randomized, Controlled Clinical Trial Active, not recruiting NCT01539239
48 Post Approval Study of the CyPass System in Patients With Primary Open Angle Glaucoma Undergoing Cataract Surgery Active, not recruiting NCT03273907
49 Frequency Of Eye Problems In Type 2 Diabetes With Chronic Kidney Disease Not yet recruiting NCT03330054
50 Adrenocorticotrophic Hormone (ACTH) for the Treatment of Sarcoid Uveitis Not yet recruiting NCT03473964 H.P. Acthar gel

Search NIH Clinical Center for Cataract-Glaucoma

Genetic Tests for Cataract-Glaucoma

Anatomical Context for Cataract-Glaucoma

MalaCards organs/tissues related to Cataract-Glaucoma:

41
Eye, Testes, Kidney, Endothelial

Publications for Cataract-Glaucoma

Articles related to Cataract-Glaucoma:

(show top 50) (show all 343)
# Title Authors PMID Year
1
Perioperative considerations and anesthesia management in patients with obstructive sleep apnea undergoing ophthalmic surgery. 38
31174989 2019
2
Relationships between Hearing Loss and the Prevalences of Cataract, Glaucoma, Diabetic Retinopathy, and Age-Related Macular Degeneration in Korea. 38
31336642 2019
3
Frequency of Ocular Diseases in Infants at a Tertiary Care Hospital. 38
31179661 2019
4
[Perioperative Anti-inflammatory Treatment in Glaucoma Surgery]. 38
31096283 2019
5
A rare cause of familial exogenous Cushing syndrome. 38
31198763 2019
6
Patient-oriented mobile applications in ophthalmology. 38
30168194 2019
7
Long-term outcomes of penetrating keratoplasty for corneal complications of herpes zoster ophthalmicus. 38
30733209 2019
8
Circular RNAs: Novel Promising Biomarkers in Ocular Diseases. 38
31171902 2019
9
Magrabi ICO Cameroon Eye Institute, Yaoundé, Cameroon: Ophthalmology Subspecialty Patient Care and Training Center in Central Africa. 38
30240727 2019
10
Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases. 38
30891116 2019
11
The use of patient-reported outcome research in modern ophthalmology: impact on clinical trials and routine clinical practice. 38
30774489 2019
12
[Who visits an ophthalmologist and how often? Results of the German nationwide adult health survey (DEGS1)]. 38
29110124 2018
13
Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders. 38
30591791 2018
14
Hypotonia and delayed motor development as an early presentation of Lowe syndrome: case report and literature review. 38
30501482 2018
15
Evaluation of content and cost of traditional eye medication in a resource-poor country - Implications for eye care practice and policy. 38
30417853 2018
16
Prevalence and associated factors of low vision and blindness among patients attending St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. 38
30176841 2018
17
Three-dimensional tubule formation assay as therapeutic screening model for ocular microvascular disorders. 38
29743587 2018
18
Pattern of Childhood Uveitis in Egypt. 38
30148647 2018
19
Ultraviolet radiation oxidative stress affects eye health. 38
29603665 2018
20
Comparison of outcomes and complications of deep anterior lamellar keratoplasty and penetrating keratoplasty performed in a large group of patients with keratoconus. 38
28534231 2018
21
Regenerating Eye Tissues to Preserve and Restore Vision. 38
29859174 2018
22
Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis. 38
29699563 2018
23
Burden of vision loss associated with eye disease in China 1990-2020: findings from the Global Burden of Disease Study 2015. 38
28607177 2018
24
Projection of Eye Disease Burden in Singapore. 38
29493707 2018
25
Ophthalmological finding in a patient with lowe syndrome. 38
30650973 2018
26
Prevalence of visual impairment and related factors in Nangarhar Province of Afghanistan: a cross sectional study. 38
30588432 2018
27
Clinical Characteristics of Wolfram Syndrome in Chinese Population and a Novel Frameshift Mutation in WFS1. 38
29483894 2018
28
Which dose of bevacizumab is more effective for the treatment of aggressive posterior retinopathy of prematurity: lower or higher dose? 38
29538588 2018
29
Comparison of success rates in eye drop instillation between sitting position and supine position. 38
30235323 2018
30
Public awareness of common eye diseases in Jordan. 38
28969614 2017
31
The role and therapeutic potential of melatonin in age-related ocular diseases. 38
28658514 2017
32
Clinical Spectrum of HLA-B27-associated Ocular Inflammation. 38
27428361 2017
33
Clinical Features and Prognostic Factors in Presumed Ocular Tuberculosis. 38
28157425 2017
34
The association between nuclear receptors and ocular diseases. 38
28187442 2017
35
Therapeutic targets of renin-angiotensin system in ocular disorders. 38
28367520 2017
36
Smartphones, tele-ophthalmology, and VISION 2020. 38
29259912 2017
37
Timed up and go test combined with self-rated multifactorial questionnaire on falls risk and sociodemographic factors predicts falls among community-dwelling older adults better than the timed up and go test on its own. 38
29138571 2017
38
Prevalence of diagnosed ocular disease in veterans with serious mental illness. 38
27796250 2016
39
Poor mental health status and its associations with demographic characteristics and chronic diseases in Chinese elderly. 38
27539269 2016
40
Ocular disease and driving. 38
27156178 2016
41
Effectiveness of UK optometric enhanced eye care services: a realist review of the literature. 38
27580754 2016
42
Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome. 38
27193151 2016
43
Determination of Serum Ceruloplasmin Concentration in Patients with Primary Open Angle Glaucoma with Cataract and Patients with Cataract Only: A Pilot Study. 38
27109647 2016
44
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model. 38
27077753 2016
45
Randomized Trial Comparing Amniotic Membrane Transplantation with Lamellar Corneal Graft for the Treatment of Corneal Thinning. 38
26807898 2016
46
Association of Socioeconomic Status with Eye Health Among Women With and Without Diabetes. 38
26666895 2016
47
Sociodemographic status of severely disabled and visually impaired elderly people in Turkey. 38
26840162 2016
48
Ultra-small algal chitosan ocular nanoparticles with iron-binding milk protein prevents the toxic effects of carbendazim pesticide. 38
26700462 2016
49
Eye Care Disparities and Health-Related Consequences in Elderly Patients with Age-Related Eye Disease. 38
27116323 2016
50
Aging and Vision. 38
26427437 2016

Variations for Cataract-Glaucoma

Expression for Cataract-Glaucoma

Search GEO for disease gene expression data for Cataract-Glaucoma.

Pathways for Cataract-Glaucoma

GO Terms for Cataract-Glaucoma

Sources for Cataract-Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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