MCID: CTR027
MIFTS: 21

Cataract-Glaucoma

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Cataract-Glaucoma

MalaCards integrated aliases for Cataract-Glaucoma:

Name: Cataract-Glaucoma 20
Cataract-Glaucoma Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
cataract-glaucoma syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases


External Ids:

ICD10 via Orphanet 33 Q12.0
Orphanet 58 ORPHA162

Summaries for Cataract-Glaucoma

MalaCards based summary : Cataract-Glaucoma, also known as cataract-glaucoma syndrome, is related to cataract and microphthalmia. An important gene associated with Cataract-Glaucoma is PITX3 (Paired Like Homeodomain 3). Affiliated tissues include eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cataract-Glaucoma

Graphical network of the top 20 diseases related to Cataract-Glaucoma:



Diseases related to Cataract-Glaucoma

Symptoms & Phenotypes for Cataract-Glaucoma

GenomeRNAi Phenotypes related to Cataract-Glaucoma according to GeneCards Suite gene sharing:

26 (show all 33)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 10.02 ATOH7 PITX3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.02 PITX3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 10.02 ATOH7
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-151 10.02 PITX3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 10.02 ATOH7
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 10.02 PITX3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 10.02 ATOH7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 10.02 PITX3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.02 OCRL
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 10.02 PITX3
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 10.02 ATOH7
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 10.02 ATOH7
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 10.02 PITX3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 10.02 ATOH7 PITX3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.6 OCRL
16 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.6 OCRL
17 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.6 OCRL
18 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 PITX3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.6 PITX3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.6 PITX3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.6 PITX3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.6 PITX3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.6 PITX3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.6 PITX3
25 Increased shRNA abundance (Z-score > 2) GR00366-A-59 9.6 OCRL
26 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.6 OCRL
27 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.6 OCRL
28 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 PITX3
29 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.6 OCRL
30 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.6 OCRL
31 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.6 PITX3
32 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.6 PITX3
33 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.6 PITX3

MGI Mouse Phenotypes related to Cataract-Glaucoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 ATOH7 OCRL PITX3
2 vision/eye MP:0005391 8.8 ATOH7 OCRL PITX3

Drugs & Therapeutics for Cataract-Glaucoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Study - ES 900 - 2020-2 Completed NCT04392349

Search NIH Clinical Center for Cataract-Glaucoma

Genetic Tests for Cataract-Glaucoma

Anatomical Context for Cataract-Glaucoma

MalaCards organs/tissues related to Cataract-Glaucoma:

40
Eye

Publications for Cataract-Glaucoma

Articles related to Cataract-Glaucoma:

(show top 50) (show all 377)
# Title Authors PMID Year
1
The outcome of surgical treatment in advanced glaucoma. 61
32654827 2021
2
Morphometric analysis of the lens in human aniridia and mouse Small eye. 61
33248069 2021
3
Internet Search Engine Queries of Common Causes of Blindness and Low Vision in the United States. 61
33039374 2021
4
Proportion, Causes and Associated Factors of Blindness Among Adult Patients Attending Tertiary Eye Care and Training Center in Ethiopia. 61
33688291 2021
5
Outcome of vision screening by community health workers at immunization outlets in Nigeria to support access to early visual evaluation in children aged 0-2 years. 61
33767959 2021
6
Relationship between refractive correction, visual symptoms, and optical device selection for low-vision patients in Taiwan. 61
31787520 2020
7
Ophthalmologic Diseases in Kidney Transplant Recipients: A Single-Center Prospective Study. 61
32402454 2020
8
Inactive bowel movement and stroke are associated with increased risks of mild cognitive impairment among community-living Singapore elderly. 61
32903214 2020
9
Variations and trends in global disease burden of age-related macular degeneration: 1990-2017. 61
32833305 2020
10
Smoking Is Associated with Higher Intraocular Pressure Regardless of Glaucoma: A Retrospective Study of 12.5 Million Patients Using the Intelligent Research in Sight (IRIS®) Registry. 61
33008558 2020
11
Effect of intracameral phenylephrine 1.0%-ketorolac 0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia after cataract surgery. 61
32541407 2020
12
Ocular complications and prophylactic strategies in Stickler syndrome: a systematic literature review. 61
32316871 2020
13
Biomarkers of inflammation and oxidative stress in ophthalmic disorders. 61
32046582 2020
14
Erratum to: Cataract, glaucoma, possible Marfan syndrome, and conception aspirations. 61
32358297 2020
15
High-Density Lipoprotein Cholesterol in Age-Related Ocular Diseases. 61
32331355 2020
16
Effect of intracameral phenylephrine/ketorolac 1.0%/0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia following cataract surgery. 61
32221152 2020
17
Epidemiology of Congenital Rubella Syndrome (CRS) in India, 2016-18, based on data from sentinel surveillance. 61
32012162 2020
18
[Capabilities of remote laser homeostasis of the conjunctiva and sclera]. 61
32366069 2020
19
Automated extraction of ophthalmic surgery outcomes from the electronic health record. 61
31706228 2020
20
Assessment of low-vault cases with an implantable collamer lens. 61
33147267 2020
21
Contrast-Sensitivity Function and Photo Stress-Recovery Time in Prediabetes. 61
32982530 2020
22
NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy. 61
32019187 2020
23
[Prevalence of ophthalmic diseases in the population older than 50 years]. 61
32504485 2020
24
Wireless, passive strain sensor in a doughnut-shaped contact lens for continuous non-invasive self-monitoring of intraocular pressure. 61
31825423 2020
25
Consultation Section: Glaucoma. Cataract, glaucoma, possible Marfan syndrome, and conception aspirations. 61
32050248 2020
26
Pathogenesis and Prevention of Worsening Axial Elongation in Pathological Myopia. 61
32256044 2020
27
Long-term outcomes of penetrating keratoplasty for corneal complications of herpes zoster ophthalmicus. 61
30733209 2019
28
Hypotonia and delayed motor development as an early presentation of Lowe syndrome: case report and literature review. 61
30501482 2019
29
Biallelic Deletion of Pxdn in Mice Leads to Anophthalmia and Severe Eye Malformation. 61
31817535 2019
30
One-Year Outcomes of Second-Generation Trabecular Micro-Bypass Stents (iStent Inject) Implantation with Cataract Surgery in Different Glaucoma Subtypes and Severities. 61
31538316 2019
31
Complications and adverse events of plaque brachytherapy for ocular melanoma. 61
31523242 2019
32
Perioperative considerations and anesthesia management in patients with obstructive sleep apnea undergoing ophthalmic surgery. 61
31174989 2019
33
Impact of Visual Impairment and Blindness on Quality of Life of Patients in Owerri, Imo State, Nigeria. 61
31619898 2019
34
Relationships between Hearing Loss and the Prevalences of Cataract, Glaucoma, Diabetic Retinopathy, and Age-Related Macular Degeneration in Korea. 61
31336642 2019
35
Frequency of Ocular Diseases in Infants at a Tertiary Care Hospital. 61
31179661 2019
36
[Perioperative Anti-inflammatory Treatment in Glaucoma Surgery]. 61
31096283 2019
37
A rare cause of familial exogenous Cushing syndrome. 61
31198763 2019
38
Patient-oriented mobile applications in ophthalmology. 61
30168194 2019
39
Circular RNAs: Novel Promising Biomarkers in Ocular Diseases. 61
31171902 2019
40
Outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing, a 16-year experience. 61
31496763 2019
41
Anterior chamber angle in aniridia with and without glaucoma. 61
31496636 2019
42
Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases. 61
30891116 2019
43
Magrabi ICO Cameroon Eye Institute, Yaoundé, Cameroon: Ophthalmology Subspecialty Patient Care and Training Center in Central Africa. 61
30240727 2019
44
[Features of the course of anterior uveitis associated with HLA-B27 antigen]. 61
31691649 2019
45
Pattern of Childhood Uveitis in Egypt. 61
30148647 2019
46
The use of patient-reported outcome research in modern ophthalmology: impact on clinical trials and routine clinical practice. 61
30774489 2019
47
[Who visits an ophthalmologist and how often? Results of the German nationwide adult health survey (DEGS1)]. 61
29110124 2018
48
Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders. 61
30591791 2018
49
Evaluation of content and cost of traditional eye medication in a resource-poor country - Implications for eye care practice and policy. 61
30417853 2018
50
Prevalence and associated factors of low vision and blindness among patients attending St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. 61
30176841 2018

Variations for Cataract-Glaucoma

Expression for Cataract-Glaucoma

Search GEO for disease gene expression data for Cataract-Glaucoma.

Pathways for Cataract-Glaucoma

GO Terms for Cataract-Glaucoma

Molecular functions related to Cataract-Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific double-stranded DNA binding GO:1990837 8.62 PITX3 ATOH7

Sources for Cataract-Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....