MCID: CTR027
MIFTS: 20

Cataract-Glaucoma

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Cataract-Glaucoma

MalaCards integrated aliases for Cataract-Glaucoma:

Name: Cataract-Glaucoma 54
Cataract-Glaucoma Syndrome 60

Characteristics:

Orphanet epidemiological data:

60
cataract-glaucoma syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

ICD10 via Orphanet 35 Q12.0
Orphanet 60 ORPHA162

Summaries for Cataract-Glaucoma

MalaCards based summary : Cataract-Glaucoma, also known as cataract-glaucoma syndrome, is related to cataract and persistent hyperplastic primary vitreous, autosomal recessive. An important gene associated with Cataract-Glaucoma is PITX3 (Paired Like Homeodomain 3). Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Cataract-Glaucoma

Diseases related to Cataract-Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 9, show less)
# Related Disease Score Top Affiliating Genes
1 cataract 30.4 OCRL PITX3
2 persistent hyperplastic primary vitreous, autosomal recessive 11.4
3 armfield x-linked mental retardation syndrome 11.2
4 lowe oculocerebrorenal syndrome 11.2
5 fuchs' heterochromic uveitis 11.2
6 macular degeneration, age-related, 1 10.1
7 microvascular complications of diabetes 5 10.0
8 morgagni cataract 10.0
9 lens disease 9.5 OCRL PITX3

Graphical network of the top 20 diseases related to Cataract-Glaucoma:



Diseases related to Cataract-Glaucoma

Symptoms & Phenotypes for Cataract-Glaucoma

GenomeRNAi Phenotypes related to Cataract-Glaucoma according to GeneCards Suite gene sharing:

27 (showing 29, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.9 ATOH7 PITX3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.9 OCRL
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.9 ATOH7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.9 OCRL
5 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.9 PITX3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.9 OCRL
7 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.9 ATOH7
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.9 PITX3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.9 PITX3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.9 PITX3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.9 ATOH7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.9 ATOH7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.9 PITX3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.9 PITX3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.9 ATOH7
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.9 PITX3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.9 PITX3 OCRL
18 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.9 OCRL
19 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.9 PITX3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.9 OCRL
21 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.9 PITX3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.9 PITX3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.9 PITX3
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.5 ATOH7
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.5 OCRL
26 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.5 ATOH7
27 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.5 ATOH7 OCRL
28 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.5 ATOH7
29 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.5 OCRL

MGI Mouse Phenotypes related to Cataract-Glaucoma:

47 (showing 2, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 ATOH7 OCRL PITX3
2 vision/eye MP:0005391 8.8 ATOH7 OCRL PITX3

Drugs & Therapeutics for Cataract-Glaucoma

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 Comparison of Phacotrabeculectomy and Trabeculectomy in the Treatment of Primary Angle-closure Glaucoma (PACG) Completed NCT01298635 Not Applicable
2 A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration Terminated NCT02479386 Not Applicable

Search NIH Clinical Center for Cataract-Glaucoma

Genetic Tests for Cataract-Glaucoma

Anatomical Context for Cataract-Glaucoma

MalaCards organs/tissues related to Cataract-Glaucoma:

42
Eye

Publications for Cataract-Glaucoma

Articles related to Cataract-Glaucoma:

(showing 16, show less)
# Title Authors Year
1
Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome. ( 27193151 )
2016
2
Combined cataract-glaucoma surgery using the intracanalicular Eyepass glaucoma implant: first clinical results of a prospective pilot study. ( 18242448 )
2008
3
Knowledge about cataract, glaucoma, and age related macular degeneration in the Hong Kong Chinese population. ( 12234882 )
2002
4
Circumferential perilimbal anesthesia for combined cataract glaucoma surgery. ( 10100254 )
1999
5
A prospective randomized comparison of two techniques of combined cataract-glaucoma surgery. ( 10541897 )
1999
6
Cataract, glaucoma and season of birth amongst patients born on the Indian subcontinent. ( 10218303 )
1998
7
Combined cataract/glaucoma procedures in patients on chronic miotics. ( 8259258 )
1993
8
A new technique for combined cataract/glaucoma procedures in patients on chronic miotics. ( 8351096 )
1993
9
Combined cataract-glaucoma surgery using the THC:YAG (holmium) laser ab interno without gonioscopy. ( 1436972 )
1992
10
Combined cataract-glaucoma operation and its complications with the 7-S-intraocular lens. ( 3595960 )
1987
11
The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. ( 7444756 )
1980
12
Combined simultaneous cataract glaucoma surgery. ( 360803 )
1978
13
Combined cataract-glaucoma operation. ( 1070879 )
1976
14
The partial-punch: a new combined cataract-glaucoma operation. ( 1264419 )
1976
15
A simultaneous cataract-glaucoma operation. ( 13712279 )
1960
16
Miscellaneous ophthalmic surgery, including two techniques of keratoplasty, cataract, glaucoma, keratectomies and muscles. ( 20261921 )
1947

Variations for Cataract-Glaucoma

Expression for Cataract-Glaucoma

Search GEO for disease gene expression data for Cataract-Glaucoma.

Pathways for Cataract-Glaucoma

GO Terms for Cataract-Glaucoma

Sources for Cataract-Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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