MCID: CDQ001
MIFTS: 40

Cauda Equina Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Cauda Equina Syndrome

MalaCards integrated aliases for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 12 53 15 73
Polyradiculopathy 44 73
Cauda Equina 55

Classifications:



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Disease Ontology 12 DOID:11577
ICD10 33 G83.4
ICD9CM 35 344.6
MeSH 44 D011128
NCIt 50 C35436
UMLS 73 C0392548

Summaries for Cauda Equina Syndrome

NIH Rare Diseases : 53 Cauda equina syndrome (CES) refers to a group of symptoms that occur when nerves in the cauda equina (a collection of nerve roots that spread out from the bottom of the spinal cord) become compressed or damaged. These nerves roots connect the central nervous system and peripheral nervous system. CES can lead to pain, numbness, and weakness in the lower back, pelvic area and legs; "foot drop"; problems with bowel or bladder control; sexual dysfunction; and even paralysis. CES is considered a medical emergency and requires hospitalization. Therefore, people with unexplained onset of symptoms should seek medical attention as soon as possible and consult with a neurologist or neurosurgeon.  CES is most commonly caused by a herniated disk in the lumbar spine. Other causes of CES may include a birth abnormality (such as spina bifida), a spinal infection or tumor, trauma or injury to the lower back, spinal stenosis, a spinal arteriovenous malformation, and complications after spinal surgery. CES can be difficult to diagnose since symptoms vary and they may mimic other conditions. Tests that may be used to diagnose CES include MRI, CT scan, and myelogram (a special type of X-ray of the spinal canal). Treatment usually targets the underlying cause of CES (removing the cause of nerve pressure) and most often involves urgent surgery to prevent permanent neurologic impairment. How well a person recovers from CES often depends on the underlying cause and how promptly they are treated. Symptoms are more likely to improve or go away if the cause is identified quickly and treatment begins right away. Some people have significant improvement of symptoms and quality of life after treatment. However, others may have permanent neurologic impairment, chronic pain, and/or mental health problems due to the impact of symptoms on social life and relationships.

MalaCards based summary : Cauda Equina Syndrome, also known as polyradiculopathy, is related to cauda equina neoplasm and cauda equina intradural extramedullary astrocytoma. An important gene associated with Cauda Equina Syndrome is NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1), and among its related pathways/superpathways is Adipogenesis. The drugs Chloroprocaine and Procaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, testes and bone, and related phenotype is limbs/digits/tail.

Disease Ontology : 12 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia : 76 Cauda equina syndrome (CES) is a condition due to damage to the bundle of nerves below the end of the... more...

Related Diseases for Cauda Equina Syndrome

Diseases related to Cauda Equina Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 cauda equina neoplasm 12.6
2 cauda equina intradural extramedullary astrocytoma 12.3
3 polyradiculopathy 12.2
4 spinal disease 11.2
5 astroblastoma 11.2
6 chronic polyradiculoneuritis 11.0
7 spondylitis 10.6
8 spondyloarthropathy 1 10.6
9 lymphoma 10.4
10 arachnoiditis 10.4
11 spinal stenosis 10.3
12 lipomatosis 10.2
13 meningitis 10.2
14 epidural abscess 10.2
15 b-cell lymphomas 10.2
16 thrombosis 10.2
17 arachnoid cysts 10.2
18 ependymoma 10.2
19 aneurysm 10.2
20 back pain 10.2
21 leukemia 10.1
22 sarcoma 10.1
23 aortic aneurysm, familial abdominal, 1 10.1
24 spinal arachnoiditis 10.1
25 spondylolisthesis 10.1
26 hydrocephalus 10.1
27 aortic aneurysm 10.1
28 radiculopathy 10.1
29 neuropathy 10.0
30 peroneal nerve paralysis 10.0 ALDH5A1 PMP22
31 small cell cancer of the lung 10.0
32 lung cancer 10.0
33 chordoma 10.0
34 aging 10.0
35 arteriovenous fistula 10.0
36 hemangioma 10.0
37 meningocele 10.0
38 arteriovenous malformation 10.0
39 cervicitis 10.0
40 myelitis 10.0
41 myxopapillary ependymoma 10.0
42 paget's disease of bone 10.0
43 bacterial meningitis 10.0
44 ewing's family of tumors 10.0
45 glioblastoma 10.0
46 tarlov cysts 10.0
47 breast cancer 9.8
48 chiari malformation type i 9.8
49 epidermoid cysts 9.8
50 glioma susceptibility 1 9.8

Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to Cauda Equina Syndrome

Symptoms & Phenotypes for Cauda Equina Syndrome

MGI Mouse Phenotypes related to Cauda Equina Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 BMP2 EGR2 NR1D1 PMP22

Drugs & Therapeutics for Cauda Equina Syndrome

Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chloroprocaine Approved 133-16-4 8612
2
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
3 Anesthetics
4 Anesthetics, Local
5 Central Nervous System Depressants
6 Peripheral Nervous System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
2 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056 Not Applicable
3 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328 Not Applicable
4 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
5 Characteristics of Back Pain Callers Completed NCT03474068
6 BLB Study Back or Leg Pain and Bladder Symptoms Study Recruiting NCT03325374
7 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression Not yet recruiting NCT03529708 Not Applicable
8 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Withdrawn NCT02806167 Not Applicable

Search NIH Clinical Center for Cauda Equina Syndrome

Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

Anatomical Context for Cauda Equina Syndrome

MalaCards organs/tissues related to Cauda Equina Syndrome:

41
Spinal Cord, Testes, Bone, B Cells, Breast, Lung, T Cells

Publications for Cauda Equina Syndrome

Articles related to Cauda Equina Syndrome:

(show top 50) (show all 566)
# Title Authors Year
1
Cauda equina syndrome during pregnancy: A condition to consider. ( 29929101 )
2018
2
Concomitant mycotic abdominal aortic aneurysm and lumbartuberculous spondylitis with cauda equina syndrome: a rare condition - a case report and literature review. ( 29479482 )
2018
3
Cauda equina syndrome following an uneventful spinal anesthesia in a patient undergoing drainage of the Bartholin abscess: A case report. ( 29742719 )
2018
4
Neurological recovery after traumatic Cauda Equina syndrome due to glass fragments: An unusual case. ( 29350375 )
2018
5
Large central lumbar disc herniation causing acute cauda equina syndrome with loss of evoked potentials during prone positioning for surgery. ( 29629233 )
2018
6
Time to implement a national referral pathway for suspected cauda equina syndrome: review and outcome of 250 referrals. ( 29607679 )
2018
7
Dural Ectasia and Cauda Equina Syndrome: A Rare Complication of Long-standing Fusion. ( 29682062 )
2018
8
Outcomes reported after surgery for Cauda Equina Syndrome: A Systematic Literature Review. ( 29432394 )
2018
9
Influence of timing of surgery on Cauda equina syndrome: Outcomes at a national spinal centre. ( 29657470 )
2018
10
Epidemiology of cauda equina syndrome. What changed until 2015. ( 29367915 )
2018
11
Time Factor and Disc Herniation Size: Are They Really Predictive for Outcome of Urinary Dysfunction in Patients With Cauda Equina Syndrome? ( 29425362 )
2018
12
Quantifying the clinical aspects of the cauda equina syndrome - The Cauda Scale (TCS). ( 29519166 )
2018
13
Metastatic biphasic pleural mesothelioma presenting with cauda equina syndrome. ( 29977434 )
2018
14
Assessment and management of cauda equina syndrome. ( 29935940 )
2018
15
Acute cauda equina syndrome following orthopedic procedures as a result of epidural anesthesia. ( 29721359 )
2018
16
An Unusual Cause of Cauda Equina Syndrome: Lumbar Epidural Venous Engorgement. ( 29904039 )
2018
17
Cauda equina syndrome secondary to leptomeningeal metastases from recurrent primary peritoneal carcinoma. ( 29515655 )
2018
18
Lumbar spinal canal MRI diameter is smaller in herniated disc cauda equina syndrome patients. ( 29023556 )
2017
19
Obesity and spinal epidural lipomatosis in cauda equina syndrome. ( 28756300 )
2017
20
Cauda Equina Syndrome Due to Lumbar Disc Herniation: a Review of Literature. ( 29341941 )
2017
21
Prediction of the outcome of bladder dysfunction based on electrically induced reflex findings in patients with cauda equina syndrome: A retrospective study. ( 28538420 )
2017
22
Conus Medullaris Arachnoid Cyst Presenting as Cauda Equina Syndrome. ( 29114289 )
2017
23
Cauda Equina Syndrome Due To Dural Sac Shift with Engorgement of the Epidural Venous Plexus: Rare Complication After Lumbar Microdiscectomy. ( 28546122 )
2017
24
Leptomeningeal Carcinomatosis Presenting as Cauda Equina Syndrome. ( 28904471 )
2017
25
Neisseria meningitidis subdural empyema causing acute cauda equina syndrome. ( 28653638 )
2017
26
Acute flaccid paraparesis (cauda equina syndrome) in a patient with Bardet-Biedl syndrome. ( 28566787 )
2017
27
Anterior lumbar discectomy and fusion for acute cauda equina syndrome caused by recurrent disc prolapse: report of 3 cases. ( 28708040 )
2017
28
Cauda equina syndrome caused by filum terminale lipoma: magnetic resonance imaging features and surgical treatment. ( 28444101 )
2017
29
Unusual cauda equina syndrome due to multifocal ependymoma infiltrated by lymphoma. ( 29354750 )
2017
30
Early cauda equina syndrome (CESE). ( 28478686 )
2017
31
Editorial. Use of anterior lumbar discectomy and interbody fusion in the management of recurrent lumbar disc herniation and cauda equina syndrome. ( 28708042 )
2017
32
Incomplete cauda equina syndrome secondary to haemorrhage within a Tarlov cyst. ( 28784878 )
2017
33
Dengue fever presenting as cauda equina syndrome. ( 28739570 )
2017
34
Neurosurgeon or spinal surgeon - who should treat cauda equina syndrome? ( 28637116 )
2017
35
Analysis of clinical and neurological outcomes in patients with cauda equina syndrome caused by acute lumbar disc herniation: a retrospective-prospective study. ( 29137416 )
2017
36
Elsberg syndrome: A rarely recognized cause of cauda equina syndrome and lower thoracic myelitis. ( 28534040 )
2017
37
Guidelines for cauda equina syndrome. Red flags and white flags. Systematic review and implications for triage. ( 28637110 )
2017
38
Misplacement of Stent Into Epidural Venous Plexus With Resultant Cauda Equina Syndrome and Open Surgical Treatment: A Case Report. ( 29211872 )
2017
39
Idiopathic Spinal Epidural Lipomatosis Causing Cauda Equina Syndrome. ( 29849325 )
2017
40
The lived experience of Cauda Equina Syndrome: a qualitative analysis. ( 28786413 )
2017
41
Erratum: Against the odds: extraordinary recovery from complete cauda equina syndrome following L3 fracture. Time still matters. ( 28503318 )
2017
42
A Good Short-term Outcome in Delayed Decompression of Cauda Equina Syndrome in<i>Klebsiella pneumoniae</i>Spinal Epidural Abscess: A Case Report. ( 29021888 )
2017
43
Cauda Equina Syndrome in a Lactating Mother - A Safe Treatment Approach. ( 28969225 )
2017
44
Contained ruptured abdominal aortic aneurysm presenting as cauda equina syndrome. ( 28062419 )
2017
45
Cauda Equina Syndrome Due to Vigorous Back Massage With Spinal Manipulation in a Patient With Pre-Existing Lumbar Disc Herniation: A Case Report and Literature Review. ( 28796647 )
2017
46
Definitions of traumatic conus medullaris and cauda equina syndrome: a systematic literature review. ( 28534496 )
2017
47
Persistent cauda equina syndrome after caudal epidural injection under severe spinal stenosis: a case report. ( 28652808 )
2017
48
Erratum: Management of neglected sacral fracture with cauda equina syndrome: report of two cases with review of literature. ( 28067337 )
2016
49
Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. ( 27891041 )
2016
50
Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine. ( 26882861 )
2016

Variations for Cauda Equina Syndrome

Expression for Cauda Equina Syndrome

Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for Cauda Equina Syndrome

Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.74 BMP2 EGR2

GO Terms for Cauda Equina Syndrome

Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.43 BMP2 EGR2 NR1D1
2 myelination GO:0042552 9.16 EGR2 PMP22
3 peripheral nervous system development GO:0007422 8.96 EGR2 PMP22
4 respiratory electron transport chain GO:0022904 8.62 ALDH5A1 MT-CO3

Sources for Cauda Equina Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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