MCID: CDQ001
MIFTS: 44

Cauda Equina Syndrome

Categories: Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cauda Equina Syndrome

MalaCards integrated aliases for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 12 53 15 73
Polyradiculopathy 44 73
Cauda Equina 55

Classifications:



External Ids:

Disease Ontology 12 DOID:11577
ICD10 33 G83.4
ICD9CM 35 344.6
MeSH 44 D011128
NCIt 50 C35436
SNOMED-CT 68 89356000

Summaries for Cauda Equina Syndrome

NIH Rare Diseases : 53 Cauda equina syndrome (CES) refers to a group of symptoms that occur when nerves in the cauda equina (a collection of nerve roots that spread out from the bottom of the spinal cord) become compressed or damaged. These nerves roots connect the central nervous system and peripheral nervous system. CES can lead to pain, numbness, and weakness in the lower back, pelvic area and legs; "foot drop"; problems with bowel or bladder control; sexual dysfunction; and even paralysis. CES is considered a medical emergency and requires hospitalization. Therefore, people with unexplained onset of symptoms should seek medical attention as soon as possible and consult with a neurologist or neurosurgeon.  CES is most commonly caused by a herniated disk in the lumbar spine. Other causes of CES may include a birth abnormality (such as spina bifida), a spinal infection or tumor, trauma or injury to the lower back, spinal stenosis, a spinal arteriovenous malformation, and complications after spinal surgery. CES can be difficult to diagnose since symptoms vary and they may mimic other conditions. Tests that may be used to diagnose CES include MRI, CT scan, and myelogram (a special type of X-ray of the spinal canal). Treatment usually targets the underlying cause of CES (removing the cause of nerve pressure) and most often involves urgent surgery to prevent permanent neurologic impairment. How well a person recovers from CES often depends on the underlying cause and how promptly they are treated. Symptoms are more likely to improve or go away if the cause is identified quickly and treatment begins right away. Some people have significant improvement of symptoms and quality of life after treatment. However, others may have permanent neurologic impairment, chronic pain, and/or mental health problems due to the impact of symptoms on social life and relationships.

MalaCards based summary : Cauda Equina Syndrome, also known as polyradiculopathy, is related to tooth disease and charcot-marie-tooth disease, demyelinating, type 1b. An important gene associated with Cauda Equina Syndrome is NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1), and among its related pathways/superpathways are Brain-Derived Neurotrophic Factor (BDNF) signaling pathway and Adipogenesis. The drugs Procaine and Chloroprocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, testes and bone, and related phenotype is limbs/digits/tail.

Disease Ontology : 12 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia : 76 Cauda equina syndrome (CES) is a condition due to damage to the bundle of nerves below the end of the... more...

Related Diseases for Cauda Equina Syndrome

Diseases related to Cauda Equina Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 tooth disease 29.8 EGR2 PMP22
2 charcot-marie-tooth disease, demyelinating, type 1b 29.7 EGR2 PMP22
3 cauda equina neoplasm 12.7
4 cauda equina intradural extramedullary astrocytoma 12.4
5 polyradiculopathy 12.4
6 spinal disease 11.4
7 astroblastoma 11.4
8 chronic polyradiculoneuritis 11.1
9 spondylitis 10.8
10 spondyloarthropathy 1 10.8
11 lymphoma 10.5
12 spinal stenosis 10.4
13 lipomatosis 10.4
14 hemangioblastoma 10.4
15 arachnoiditis 10.4
16 capillary hemangioma 10.4
17 thrombosis 10.3
18 epidural abscess 10.3
19 spondylosis 10.3
20 neurofibroma 10.3
21 clear cell meningioma 10.3
22 plexiform neurofibroma 10.3
23 b-cell lymphomas 10.3
24 meningitis 10.3
25 arachnoid cysts 10.3
26 ependymoma 10.3
27 neurilemmoma 10.3
28 sarcoma 10.3
29 lymphosarcoma 10.2
30 aortic aneurysm, familial abdominal, 1 10.2
31 spondylolisthesis 10.2
32 hydrocephalus 10.2
33 aortic aneurysm 10.2
34 syringomyelia 10.2
35 histiocytosis 10.2
36 neuropathy 10.1
37 small cell cancer of the lung 10.1
38 spinal arachnoiditis 10.1
39 lung cancer 10.1
40 chordoma 10.1
41 arteriovenous fistula 10.1
42 hemangioma 10.1
43 leukemia 10.1
44 meningocele 10.1
45 arteriovenous malformation 10.1
46 gaucher's disease 10.1
47 myelitis 10.1
48 radiculopathy 10.1
49 myxopapillary ependymoma 10.1
50 paget's disease of bone 10.1

Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to Cauda Equina Syndrome

Symptoms & Phenotypes for Cauda Equina Syndrome

MGI Mouse Phenotypes related to Cauda Equina Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 BMP2 EGR2 NR1D1 PMP22

Drugs & Therapeutics for Cauda Equina Syndrome

Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
2
Chloroprocaine Approved 133-16-4 8612
3 Anesthetics, Local
4 Anesthetics
5 Central Nervous System Depressants
6 Peripheral Nervous System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
2 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056 Not Applicable
3 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328 Not Applicable
4 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
5 Characteristics of Back Pain Attendances at ED Completed NCT03762174
6 Characteristics of Back Pain Callers Completed NCT03474068
7 BLB Study Back or Leg Pain and Bladder Symptoms Study Recruiting NCT03325374
8 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression Not yet recruiting NCT03529708 Not Applicable
9 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Withdrawn NCT02806167 Not Applicable

Search NIH Clinical Center for Cauda Equina Syndrome

Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

Anatomical Context for Cauda Equina Syndrome

MalaCards organs/tissues related to Cauda Equina Syndrome:

41
Spinal Cord, Testes, Bone, B Cells, Lung, Breast, Myeloid

Publications for Cauda Equina Syndrome

Articles related to Cauda Equina Syndrome:

(show top 50) (show all 623)
# Title Authors Year
1
Cauda equina syndrome during pregnancy: A condition to consider. ( 29929101 )
2018
2
Concomitant mycotic abdominal aortic aneurysm and lumbartuberculous spondylitis with cauda equina syndrome: a rare condition - a case report and literature review. ( 29479482 )
2018
3
Cauda equina syndrome following an uneventful spinal anesthesia in a patient undergoing drainage of the Bartholin abscess: A case report. ( 29742719 )
2018
4
Neurological recovery after traumatic Cauda Equina syndrome due to glass fragments: An unusual case. ( 29350375 )
2018
5
Large central lumbar disc herniation causing acute cauda equina syndrome with loss of evoked potentials during prone positioning for surgery. ( 29629233 )
2018
6
Time to implement a national referral pathway for suspected cauda equina syndrome: review and outcome of 250 referrals. ( 29607679 )
2018
7
Dural Ectasia and Cauda Equina Syndrome: A Rare Complication of Long-standing Fusion. ( 29682062 )
2018
8
Outcomes reported after surgery for Cauda Equina Syndrome: A Systematic Literature Review. ( 29432394 )
2018
9
Influence of timing of surgery on Cauda equina syndrome: Outcomes at a national spinal centre. ( 29657470 )
2018
10
Epidemiology of cauda equina syndrome. What changed until 2015. ( 29367915 )
2018
11
Time Factor and Disc Herniation Size: Are They Really Predictive for Outcome of Urinary Dysfunction in Patients With Cauda Equina Syndrome? ( 29425362 )
2018
12
Quantifying the clinical aspects of the cauda equina syndrome - The Cauda Scale (TCS). ( 29519166 )
2018
13
Metastatic biphasic pleural mesothelioma presenting with cauda equina syndrome. ( 29977434 )
2018
14
Assessment and management of cauda equina syndrome. ( 29935940 )
2018
15
Acute cauda equina syndrome following orthopedic procedures as a result of epidural anesthesia. ( 29721359 )
2018
16
An Unusual Cause of Cauda Equina Syndrome: Lumbar Epidural Venous Engorgement. ( 29904039 )
2018
17
Cauda equina syndrome secondary to leptomeningeal metastases from recurrent primary peritoneal carcinoma. ( 29515655 )
2018
18
Outcomes Following Surgical Management of Cauda Equina Syndrome: Does Race Matter? ( 28434102 )
2018
19
Cauda equina syndrome secondary to neurolymphomatosis: Case report and literature review. ( 28941783 )
2018
20
Posterior Epidural Migration of a Lumbar Disc Herniation Causing Cauda Equina Syndrome: A Case Report. ( 30087815 )
2018
21
Cauda equina syndrome in a patient diagnosed with type 1 Gaucher disease: a rare case. ( 30094495 )
2018
22
Lumbar Arthroplasty Core Herniation Presenting With Cauda Equina Syndrome: Case Report of a Rare Complication. ( 30099564 )
2018
23
Epidural venous plexus engorgement due to inferior vena cava thrombosis resulting in cauda equina syndrome: Case report and literature review. ( 30105127 )
2018
24
Surgical Intervention for Cauda Equina Syndrome in the Second and Third Trimesters of Pregnancy: A Report of Three Cases. ( 30211711 )
2018
25
The clinical features and outcome of scan-negative and scan-positive cases in suspected cauda equina syndrome: a retrospective study of 276 patients. ( 30298195 )
2018
26
Bladder Recovery Patterns in Patients with Complete Cauda Equina Syndrome: A Single-Center Study. ( 30322260 )
2018
27
Cauda equina syndrome-the questions. ( 30374638 )
2018
28
Lumbar Intraspinal Osteolipoma Presenting as Cauda Equina Syndrome: A Case Report and Review of Literature. ( 30425872 )
2018
29
Does the Surgical Timing and Decompression Alone or Fusion Surgery in Lumbar Stenosis Influence Outcome in Cauda Equina Syndrome? ( 30472822 )
2018
30
Understanding cauda equina syndrome: protocol for a UK multicentre prospective observational cohort study. ( 30552283 )
2018
31
Acute polyradiculopathy secondary to idelalisib in Relapsed Classical Hodgkin's lymphoma. ( 30191811 )
2018
32
Management of chronic inflammatory demyelinating polyradiculopathy. ( 30045075 )
2018
33
Diagnostic usefulness of plexus MRI in chronic inflammatory demyelinating polyradiculopathy without electrodiagnostic criteria of demyelination. ( 30431216 )
2018
34
Lumbar spinal canal MRI diameter is smaller in herniated disc cauda equina syndrome patients. ( 29023556 )
2017
35
Obesity and spinal epidural lipomatosis in cauda equina syndrome. ( 28756300 )
2017
36
Cauda Equina Syndrome Due to Lumbar Disc Herniation: a Review of Literature. ( 29341941 )
2017
37
Prediction of the outcome of bladder dysfunction based on electrically induced reflex findings in patients with cauda equina syndrome: A retrospective study. ( 28538420 )
2017
38
Conus Medullaris Arachnoid Cyst Presenting as Cauda Equina Syndrome. ( 29114289 )
2017
39
Cauda Equina Syndrome Due To Dural Sac Shift with Engorgement of the Epidural Venous Plexus: Rare Complication After Lumbar Microdiscectomy. ( 28546122 )
2017
40
Leptomeningeal Carcinomatosis Presenting as Cauda Equina Syndrome. ( 28904471 )
2017
41
Neisseria meningitidis subdural empyema causing acute cauda equina syndrome. ( 28653638 )
2017
42
Acute flaccid paraparesis (cauda equina syndrome) in a patient with Bardet-Biedl syndrome. ( 28566787 )
2017
43
Anterior lumbar discectomy and fusion for acute cauda equina syndrome caused by recurrent disc prolapse: report of 3 cases. ( 28708040 )
2017
44
Cauda equina syndrome caused by filum terminale lipoma: magnetic resonance imaging features and surgical treatment. ( 28444101 )
2017
45
Unusual cauda equina syndrome due to multifocal ependymoma infiltrated by lymphoma. ( 29354750 )
2017
46
Early cauda equina syndrome (CESE). ( 28478686 )
2017
47
Editorial. Use of anterior lumbar discectomy and interbody fusion in the management of recurrent lumbar disc herniation and cauda equina syndrome. ( 28708042 )
2017
48
Incomplete cauda equina syndrome secondary to haemorrhage within a Tarlov cyst. ( 28784878 )
2017
49
Dengue fever presenting as cauda equina syndrome. ( 28739570 )
2017
50
Neurosurgeon or spinal surgeon - who should treat cauda equina syndrome? ( 28637116 )
2017

Variations for Cauda Equina Syndrome

Expression for Cauda Equina Syndrome

Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for Cauda Equina Syndrome

Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 BMP2 EGR2
2 10.74 BMP2 EGR2

GO Terms for Cauda Equina Syndrome

Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.43 BMP2 EGR2 NR1D1
2 myelination GO:0042552 9.16 EGR2 PMP22
3 peripheral nervous system development GO:0007422 8.96 EGR2 PMP22
4 respiratory electron transport chain GO:0022904 8.62 ALDH5A1 MT-CO3

Sources for Cauda Equina Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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