Cauda Equina Syndrome

Categories: Mental diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cauda Equina Syndrome

MalaCards integrated aliases for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 12 20 44 15 17 70 32
Polyradiculopathy 70
Cauda Equina 54


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Disease Ontology 12 DOID:11577
ICD9CM 34 344.6
MeSH 44 D000077684
NCIt 50 C35436
SNOMED-CT 67 89356000
ICD10 32 G83.4
UMLS 70 C0032586 C0392548

Summaries for Cauda Equina Syndrome

GARD : 20 Cauda equina syndrome (CES) refers to a group of symptoms that occur when nerves in the cauda equina (a collection of nerve roots that spread out from the bottom of the spinal cord) become compressed or damaged. These nerves roots connect the central nervous system and peripheral nervous system. CES can lead to pain, numbness, and weakness in the lower back, pelvic area and legs; " foot drop "; problems with bowel or bladder control; sexual dysfunction; and even paralysis. CES is considered a medical emergency and requires hospitalization. Therefore, people with unexplained onset of symptoms should seek medical attention as soon as possible and consult with a neurologist or neurosurgeon. CES is most commonly caused by a herniated disk in the lumbar spine. Other causes of CES may include a birth abnormality (such as spina bifida), a spinal infection or tumor, trauma or injury to the lower back, spinal stenosis, a spinal arteriovenous malformation, and complications after spinal surgery. CES can be difficult to diagnose since symptoms vary and they may mimic other conditions. Tests that may be used to diagnose CES include MRI, CT scan, and myelogram (a special type of X-ray of the spinal canal). Treatment usually targets the underlying cause of CES (removing the cause of nerve pressure) and most often involves urgent surgery to prevent permanent neurologic impairment. How well a person recovers from CES often depends on the underlying cause and how promptly they are treated. Symptoms are more likely to improve or go away if the cause is identified quickly and treatment begins right away. Some people have significant improvement of symptoms and quality of life after treatment. However, others may have permanent neurologic impairment, chronic pain, and/or mental health problems due to the impact of symptoms on social life and relationships.

MalaCards based summary : Cauda Equina Syndrome, also known as polyradiculopathy, is related to astroblastoma and arachnoiditis. An important gene associated with Cauda Equina Syndrome is BLVRB (Biliverdin Reductase B), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Mycophenolic acid and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and myeloid.

Disease Ontology : 12 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia : 73 Cauda equina syndrome (CES) is a condition that occurs when the bundle of nerves below the end of the... more...

Related Diseases for Cauda Equina Syndrome

Diseases related to Cauda Equina Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 591)
# Related Disease Score Top Affiliating Genes
1 astroblastoma 32.0 SYP GFAP
2 arachnoiditis 31.4 POMC CRP
3 spondylolisthesis 31.1 CRP BMP2
4 epidural abscess 31.1 F2 CRP
5 cellular ependymoma 30.8 SYP GFAP
6 benign ependymoma 30.8 SYP GFAP
7 clear cell meningioma 30.8 SYP GFAP
8 spondylosis 30.7 CRP BMP2
9 myxopapillary ependymoma 30.7 SYP GFAP
10 papillary ependymoma 30.6 SYP GFAP
11 papilledema 30.3 SYP F2 CRP
12 chiari malformation 30.3 SYP GFAP
13 clear cell ependymoma 30.3 SYP GFAP
14 subdural empyema 30.2 F2 CRP
15 gangliocytoma 30.2 SYP POMC GFAP
16 pleural empyema 30.2 F2 CRP
17 subependymoma 30.2 SYP GFAP
18 tanycytic ependymoma 30.2 SYP GFAP
19 papilloma of choroid plexus 30.2 SYP GFAP
20 cerebellar medulloblastoma 30.2 SYP GFAP
21 compartment syndrome 30.1 F2 CRP
22 central neurocytoma 29.8 SYP GFAP
23 osteonecrosis 29.6 F2 CYP2C8 BMP2
24 peripheral nervous system disease 29.6 SYP POMC GFAP CRP
25 deficiency anemia 29.5 F2 CRP BMP2 BLVRB
26 cauda equina neoplasm 11.6
27 cauda equina intradural extramedullary astrocytoma 11.4
28 spinal disease 11.3
29 inflammatory spondylopathy 10.9
30 spondylitis 10.9
31 spondyloarthropathy 1 10.9
32 back pain 10.8
33 radiculopathy 10.7
34 spinal stenosis 10.7
35 spinal arachnoiditis 10.7
36 constipation 10.6
37 neuritis 10.6
38 sexual disorder 10.6
39 meningioma, familial 10.6
40 intracranial meningioma 10.6
41 secretory meningioma 10.6
42 lymphoplasmacyte-rich meningioma 10.6
43 paraplegia 10.6
44 b-cell lymphoma 10.5
45 48,xyyy 10.5
46 foot drop 10.5
47 paresthesia 10.5
48 neurogenic bladder 10.5
49 lipomatosis 10.5
50 capillary hemangioma 10.5

Graphical network of the top 20 diseases related to Cauda Equina Syndrome:

Diseases related to Cauda Equina Syndrome

Symptoms & Phenotypes for Cauda Equina Syndrome

Drugs & Therapeutics for Cauda Equina Syndrome

Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Mycophenolic acid Approved Phase 3 24280-93-1 446541
2 Anti-Bacterial Agents Phase 3
3 Immunoglobulins Phase 3
4 Antibiotics, Antitubercular Phase 3
5 Antitubercular Agents Phase 3
6 Rho(D) Immune Globulin Phase 3
7 Immunoglobulins, Intravenous Phase 3
8 gamma-Globulins Phase 3
9 Anti-Infective Agents Phase 3
10 Antibodies Phase 3

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 A Randomized Placebo-controlled Trial on the Use of Repetitive Spinal Magnetic Stimulation as a Therapeutic Option in Patients With Intractable Neuropathic Pain of the Lower Limbs Completed NCT00443469 Phase 3
2 Does the Mycophenolate Improve the Ability of Weaning Patients Off the Treatment in Chronic Inflammatory Demyelinating Polyradiculopathy (CIDP) Completed NCT02494505 Phase 3 Mycophenolate Mofetil;placebo
3 Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases: a Randomized Phase II Clinical Trial Recruiting NCT03028337 Phase 2
4 BLB Study Back or Leg Pain and Bladder Symptoms Study Completed NCT03325374
5 The Use of the Peristeen Bowel Irrigation System for People With Cauda Equina Syndrome Completed NCT01784328
6 Stereotactic Body Radiotherapy (SBRT) Boost Following Urgent 3D Conformal Radiotherapy in the Treatment of Metastatic Epidural Spinal Cord Compression (SCC): A Phase I Feasibility Trial Recruiting NCT03529708
7 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
8 A Study Into the Use of Post-Void Bladder Scanning as Part of a Clinical Algorithm for the Assessment of Patients With Suspected Acute Cauda Equina Syndrome Withdrawn NCT02806167

Search NIH Clinical Center for Cauda Equina Syndrome

Cochrane evidence based reviews: cauda equina syndrome

Genetic Tests for Cauda Equina Syndrome

Anatomical Context for Cauda Equina Syndrome

MalaCards organs/tissues related to Cauda Equina Syndrome:

Spinal Cord, Bone, Myeloid, Lung, Pituitary, Endothelial, Brain

Publications for Cauda Equina Syndrome

Articles related to Cauda Equina Syndrome:

(show top 50) (show all 1911)
# Title Authors PMID Year
Pinprick and Light Touch Are Adequate to Establish Sensory Dysfunction in Patients with Lumbar Radicular Pain and Disc Herniation. 61
33394605 2021
Caudal Lumbar Disc Herniations Are More Likely to Require Surgery for Symptom Resolution. 61
32875890 2021
Priapism, a symptom of claudication of the cauda equina in spinal stenosis. 61
33549525 2021
Suicidal jumper's fracture reduced with hyperextension and the joystick method: A case report. 61
33718568 2021
Acute immune sensory polyradiculopathy: a new variant of Guillain-Barré syndrome. 61
33347623 2021
Arachnoiditis Ossificans of the Lumbar Spine: A Rare Cause of Progressive Cauda Equina Syndrome. 61
33508490 2021
Acute bilateral foot drop with or without cauda equina syndrome-a case series. 61
33550516 2021
In the borderland of multifocal motor neuropathy and chronic inflammatory demyelinating polyradiculopathy. 61
33074453 2021
Suspected cauda equina syndrome: no reduction in investigation, referral and treatment during the COVID-19 pandemic. 61
33682481 2021
CISP-Plus: Expanding the Spectrum of Chronic Immune Sensory Polyradiculopathy (CISP). 61
33653905 2021
Primary epidural lumbar Ewing sarcoma presenting as cauda equina syndrome in an adult patient who underwent surgical decompression: A case report. 61
33775555 2021
Physiotherapists' experiences of managing persons with suspected cauda equina syndrome: Overcoming the challenges. 61
33022867 2021
Out of hours magnetic resonance imaging for suspected cauda equina syndrome: lessons from a comparative study across two centres. 61
33645281 2021
Corrigendum to "What is the diagnostic accuracy of red flags related to cauda equina syndrome (CES), when compared to Magnetic Resonance Imaging (MRI)? A systematic review" [Musculoskeletal Science and Practice 42 (2019) 125-133]. 61
33722511 2021
Chronic inflammatory demyelinating polyradiculoneuropathy: can a diagnosis be made in patients not fulfilling electrodiagnostic criteria? 61
32959475 2021
Civilian Gun Shot Wounds Associated With Spinal Injuries. 61
33567932 2021
Disorders of the Cauda Equina. 61
33522743 2021
Spinal cord stimulation and cauda equina syndrome: Could it be a valid option? A report of two cases. 61
33558146 2021
The Proof's in the Pudding: Case of Cauda Equina Syndrome Due to Known Sarcoid. 61
32735856 2021
Large central disc herniation causing cauda equina syndrome in an adolescent. A case report. 61
33454631 2021
Chronic Undiagnosed Brucellosis Presenting as Sciatica. 61
33728133 2021
Leucine Zipper 4 Autoantibody: A Novel Germ Cell Tumor and Paraneoplastic Biomarker. 61
33583072 2021
Enterococcus faecalis infective endocarditis arising from chronic rectal prolapse in the setting of spinal cord injury. 61
33558386 2021
Juvenile Chronic Inflammatory Demyelinating Polyneuropathy Epidemiology in Sardinia, Insular Italy. 61
33111308 2021
Epidural lipomatosis in elderly patient: A rare cause of cauda equina compression. 61
33500822 2021
Metastatic melanoma of unknown origin mimicking neurofibromatosis. 61
33224396 2021
Minimally Invasive Intradural Tumor Resection. 61
32992063 2021
Paraplegia after transforaminal epidural steroid injection in a patient with severe lumbar disc herniation - A case report. 61
33472291 2021
Spinal Ependymoma Identified Following Spinal Anesthesia for Cesarean Delivery. 61
33564549 2021
Herniation of the cauda equina into the facet joint through a pseudomeningocele: A case report and literature review. 61
33598346 2021
Accuracy of Placement of Pedicle Screws in the Lumbosacral Region of Dogs Using 3D-Printed Patient-Specific Drill Guides. 61
33065746 2021
Spontaneous infarction of lumbar roots, vertebrae and paravertebral muscles. 61
33551246 2021
A practical review of functional neurological disorder (FND) for the general physician. 61
33479065 2021
Cauda equina syndrome secondary to portal vein thrombosis: case report of favorable outcome with conservative treatment. 61
33386000 2021
Chronic immune polyradiculopathies: Three clinical variants of one disease? 61
32710692 2021
Chronic immune sensory polyradiculopathy (CISP): First juvenile case description. 61
32651857 2021
Cauda Equina Syndrome as the Initial Presentation of Concurrent Plasmacytoma and Multiple Myeloma. 61
33643734 2021
Guillain-Barre Syndrome Amid Osteosarcoma Treatment: A Therapeutic Dilemma and Literature Review. 61
33542879 2021
Polyradiculopathy and Multiple Cranial Nerve Palsies - Rare Manifestations of Cerebral Venous Sinus Thrombosis. 61
33642294 2021
Lumbosacral polyradiculitis associated with brucellosis. 61
33384926 2021
Evaluation of clinical, diagnostic features and therapeutic outcome of neurobrucellosis: a case series and review of literature. 61
33287603 2021
Long-term rates of bladder dysfunction after decompression in patients with cauda equina syndrome. 61
33434651 2021
Cauda equina syndrome. 61
33436390 2021
Spinal arachnoid sleeves and their possible causative role in cauda equina syndrome and transient radicular irritation syndrome. 61
33449372 2021
Factors affecting urinary outcome after delayed decompression in complete cauda equina syndrome: "A regression model study". 61
33454810 2021
Scan-Negative Cauda Equina Syndrome: A Prospective Cohort Study. 61
33177221 2021
Vocal fold paralysis and cauda equina syndrome following spinal-epidural anesthesia: A case report. 61
33546075 2021
Do safety-net hospitals provide equitable care after decompressive surgery for acute cauda equina syndrome? 61
33203594 2021
A randomized controlled study for the treatment of middle-aged and old-aged lumbar disc herniation by Shis spine balance manipulation combined with bone and muscle guidance. 61
33371159 2020
Acute Thoracic Myelopathy. 61
33256518 2020

Variations for Cauda Equina Syndrome

Expression for Cauda Equina Syndrome

Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for Cauda Equina Syndrome

Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.7 SYP GFAP BMP2
Show member pathways
10.43 POMC CRP

GO Terms for Cauda Equina Syndrome

Sources for Cauda Equina Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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