MCID: CDQ001
MIFTS: 40

Cauda Equina Syndrome

Categories: Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cauda Equina Syndrome

MalaCards integrated aliases for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 12 54 15 17 74
Polyradiculopathy 45 74
Cauda Equina 56

Classifications:



External Ids:

Disease Ontology 12 DOID:11577
ICD9CM 36 344.6
MeSH 45 D011128
NCIt 51 C35436
SNOMED-CT 69 89356000
ICD10 34 G83.4

Summaries for Cauda Equina Syndrome

NIH Rare Diseases : 54 Cauda equina syndrome (CES) refers to a group of symptoms that occur when nerves in the cauda equina (a collection of nerve roots that spread out from the bottom of the spinal cord) become compressed or damaged. These nerves roots connect the central nervous system and peripheral nervous system. CES can lead to pain, numbness, and weakness in the lower back, pelvic area and legs; "foot drop"; problems with bowel or bladder control; sexual dysfunction; and even paralysis. CES is considered a medical emergency and requires hospitalization. Therefore, people with unexplained onset of symptoms should seek medical attention as soon as possible and consult with a neurologist or neurosurgeon.  CES is most commonly caused by a herniated disk in the lumbar spine. Other causes of CES may include a birth abnormality (such as spina bifida), a spinal infection or tumor, trauma or injury to the lower back, spinal stenosis, a spinal arteriovenous malformation, and complications after spinal surgery. CES can be difficult to diagnose since symptoms vary and they may mimic other conditions. Tests that may be used to diagnose CES include MRI, CT scan, and myelogram (a special type of X-ray of the spinal canal). Treatment usually targets the underlying cause of CES (removing the cause of nerve pressure) and most often involves urgent surgery to prevent permanent neurologic impairment. How well a person recovers from CES often depends on the underlying cause and how promptly they are treated. Symptoms are more likely to improve or go away if the cause is identified quickly and treatment begins right away. Some people have significant improvement of symptoms and quality of life after treatment. However, others may have permanent neurologic impairment, chronic pain, and/or mental health problems due to the impact of symptoms on social life and relationships.

MalaCards based summary : Cauda Equina Syndrome, also known as polyradiculopathy, is related to cauda equina neoplasm and cauda equina intradural extramedullary astrocytoma. An important gene associated with Cauda Equina Syndrome is ALDH5A1 (Aldehyde Dehydrogenase 5 Family Member A1). The drugs Melphalan and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and testes.

Disease Ontology : 12 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia : 77 Cauda equina syndrome (CES) is a condition that occurs when the bundle of nerves below the end of the... more...

Related Diseases for Cauda Equina Syndrome

Diseases related to Cauda Equina Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 cauda equina neoplasm 12.7
2 cauda equina intradural extramedullary astrocytoma 12.5
3 polyradiculopathy 12.4
4 spinal disease 11.4
5 astroblastoma 11.4
6 chronic polyradiculoneuritis 11.2
7 spondylitis 10.8
8 spondyloarthropathy 1 10.8
9 lymphoma 10.6
10 neuritis 10.5
11 spinal stenosis 10.5
12 lipomatosis 10.4
13 hemangioblastoma 10.4
14 neurofibroma 10.4
15 arachnoiditis 10.4
16 capillary hemangioma 10.4
17 intermittent claudication 10.4
18 spondylosis 10.4
19 thrombosis 10.4
20 epidural abscess 10.4
21 meningitis 10.4
22 clear cell meningioma 10.3
23 plexiform neurofibroma 10.3
24 benign ependymoma 10.3
25 arachnoid cysts 10.3
26 ependymoma 10.3
27 leukemia 10.3
28 sarcoma 10.3
29 hydrocephalus, normal-pressure 10.2
30 spinal meningioma 10.2
31 syringomyelia 10.2
32 aortic aneurysm, familial abdominal, 1 10.2
33 spondylolisthesis 10.2
34 hydrocephalus 10.2
35 mammary paget's disease 10.2
36 aortic aneurysm 10.2
37 bacterial meningitis 10.2
38 meningioma, familial 10.2
39 histiocytosis 10.2
40 secretory meningioma 10.2
41 acquired immunodeficiency syndrome 10.2
42 neuropathy 10.2
43 breast cancer 10.1
44 lipomatosis, multiple 10.1
45 small cell cancer of the lung 10.1
46 spinal arachnoiditis 10.1
47 lung cancer 10.1
48 chordoma 10.1
49 arteriovenous fistula 10.1
50 chronic inflammatory demyelinating polyneuropathy 10.1

Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to Cauda Equina Syndrome

Symptoms & Phenotypes for Cauda Equina Syndrome

Drugs & Therapeutics for Cauda Equina Syndrome

Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 460612 4053
2 Anesthetics Phase 1,Not Applicable
3 Alkylating Agents Phase 1
4 Immunologic Factors Phase 1
5 Immunosuppressive Agents Phase 1
6 Antineoplastic Agents, Alkylating Phase 1
7 Liver Extracts Phase 1
8
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
9
Chloroprocaine Approved 133-16-4 8612
10 Central Nervous System Depressants
11 Anesthetics, Local
12 Peripheral Nervous System Agents

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Spinal Magnetic Stimulation in Neuropathic Pain Completed NCT00443469 Phase 3
2 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
3 Hypofractionated Radiotherapy (16/2) for the Palliation of Complicated Bone Metastases in Patients With KPS Completed NCT02376322 Phase 2
4 Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases Active, not recruiting NCT03028337 Phase 2
5 Intra-arterial Chemotherapy for Spinal Metastases Completed NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
6 Trial for Salvage Re-Irradiation of Metastatic Spine Lesions Using Single-Fraction Stereotactic Radiosurgery Recruiting NCT02278744 Phase 1
7 High Dose Rate Brachyablation of Primary Liver Lesions Recruiting NCT02893982 Phase 1
8 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056 Not Applicable
9 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328 Not Applicable
10 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
11 Characteristics of Back Pain Attendances at ED Completed NCT03762174
12 Characteristics of Back Pain Callers Completed NCT03474068
13 The Effect of Spinal Flexion in the Lateral Decubitus Position on the Unilaterality During Spinal Anesthesia Completed NCT01321684 Not Applicable
14 Neurologic Complications in Spinal Deformity Surgery Completed NCT01305343
15 Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion Recruiting NCT03662906 Not Applicable
16 A Trial to Improve Quality of Life With Stereotactic Body Radiotherapy for Patients With Painful Bone Metastases Recruiting NCT03831243 Not Applicable
17 BLB Study Back or Leg Pain and Bladder Symptoms Study Active, not recruiting NCT03325374
18 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression Not yet recruiting NCT03529708 Not Applicable
19 Efficacy of Acupuncture for Lumbar Spinal Stenosis Not yet recruiting NCT03784729 Not Applicable
20 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Withdrawn NCT02806167 Not Applicable

Search NIH Clinical Center for Cauda Equina Syndrome

Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

Anatomical Context for Cauda Equina Syndrome

MalaCards organs/tissues related to Cauda Equina Syndrome:

42
Spinal Cord, Bone, Testes, Lung, B Cells, Breast, Myeloid

Publications for Cauda Equina Syndrome

Articles related to Cauda Equina Syndrome:

(show top 50) (show all 748)
# Title Authors Year
1
GP who failed to act on red flags for cauda equina syndrome breached duty. ( 30886121 )
2019
2
Leriche syndrome as a rare cause of cauda equina syndrome. ( 30926230 )
2019
3
A Review of Cauda Equina Syndrome in Ankylosing Spondylitis: Challenges in Diagnosis, Management, and Pathogenesis. ( 30936280 )
2019
4
Compressive Pressure versus Time in Cauda Equina Syndrome: A Systematic Review and Meta-Analysis of Experimental Studies. ( 30973513 )
2019
5
Evaluation of Nationwide Referral Pathways, Investigation and Treatment of Suspected Cauda Equina Syndrome in the United Kingdom (ENTICE). ( 30982912 )
2019
6
Are we neglecting sexual function assessment in suspected cauda equina syndrome? ( 31036485 )
2019
7
Protocol for the development of a core outcome set for cauda equina syndrome: systematic literature review, qualitative interviews, Delphi survey and consensus meeting. ( 31048424 )
2019
8
Isolated Decompression for Transverse Sacral Fractures with Cauda Equina Syndrome. ( 31089068 )
2019
9
Bacterial meningitis and cauda equina syndrome after trans-sacral epiduroscopic laser decompression: A case report. ( 30882691 )
2019
10
Cauda equina syndrome in a patient diagnosed with type 1 Gaucher disease: a rare case. ( 30094495 )
2019
11
Lumbar Arthroplasty Core Herniation Presenting With Cauda Equina Syndrome: Case Report of a Rare Complication. ( 30099564 )
2019
12
Cauda equina syndrome-the questions. ( 30374638 )
2019
13
Does the Surgical Timing and Decompression Alone or Fusion Surgery in Lumbar Stenosis Influence Outcome in Cauda Equina Syndrome? ( 30472822 )
2019
14
Cauda Equina Syndrome as the first Manifestation of von Hippel-Lindau Disease: A Case Report. ( 30780037 )
2019
15
Diagnostic usefulness of plexus magnetic resonance imaging in chronic inflammatory demyelinating polyradiculopathy without electrodiagnostic criteria of demyelination. ( 30431216 )
2019
16
Chronic immune sensorimotor polyradiculopathy: Report of a case series. ( 30697760 )
2019
17
Concomitant mycotic abdominal aortic aneurysm and lumbartuberculous spondylitis with cauda equina syndrome: a rare condition - a case report and literature review. ( 29479482 )
2018
18
Outcomes Following Surgical Management of Cauda Equina Syndrome: Does Race Matter? ( 28434102 )
2018
19
Obesity and spinal epidural lipomatosis in cauda equina syndrome. ( 28756300 )
2018
20
The lived experience of Cauda Equina Syndrome: a qualitative analysis. ( 28786413 )
2018
21
Cauda Equina Syndrome Due to Vigorous Back Massage With Spinal Manipulation in a Patient With Pre-Existing Lumbar Disc Herniation: A Case Report and Literature Review. ( 28796647 )
2018
22
Cauda equina syndrome secondary to neurolymphomatosis: Case report and literature review. ( 28941783 )
2018
23
Misplacement of Stent Into Epidural Venous Plexus With Resultant Cauda Equina Syndrome and Open Surgical Treatment: A Case Report. ( 29211872 )
2018
24
Neurological recovery after traumatic Cauda Equina syndrome due to glass fragments: An unusual case. ( 29350375 )
2018
25
Epidemiology of cauda equina syndrome. What changed until 2015. ( 29367915 )
2018
26
Time Factor and Disc Herniation Size: Are They Really Predictive for Outcome of Urinary Dysfunction in Patients With Cauda Equina Syndrome? ( 29425362 )
2018
27
Outcomes Reported After Surgery for Cauda Equina Syndrome: A Systematic Literature Review. ( 29432394 )
2018
28
Cauda equina syndrome secondary to leptomeningeal metastases from recurrent primary peritoneal carcinoma. ( 29515655 )
2018
29
Quantifying the clinical aspects of the cauda equina syndrome - The Cauda Scale (TCS). ( 29519166 )
2018
30
Time to implement a national referral pathway for suspected cauda equina syndrome: review and outcome of 250 referrals. ( 29607679 )
2018
31
Large central lumbar disc herniation causing acute cauda equina syndrome with loss of evoked potentials during prone positioning for surgery. ( 29629233 )
2018
32
Influence of timing of surgery on Cauda equina syndrome: Outcomes at a national spinal centre. ( 29657470 )
2018
33
Dural Ectasia and Cauda Equina Syndrome: A Rare Complication of Long-standing Fusion. ( 29682062 )
2018
34
Acute cauda equina syndrome following orthopedic procedures as a result of epidural anesthesia. ( 29721359 )
2018
35
Cauda equina syndrome following an uneventful spinal anesthesia in a patient undergoing drainage of the Bartholin abscess: A case report. ( 29742719 )
2018
36
An Unusual Cause of Cauda Equina Syndrome: Lumbar Epidural Venous Engorgement. ( 29904039 )
2018
37
Cauda equina syndrome during pregnancy: A condition to consider. ( 29929101 )
2018
38
Assessment and management of cauda equina syndrome. ( 29935940 )
2018
39
Metastatic biphasic pleural mesothelioma presenting with cauda equina syndrome. ( 29977434 )
2018
40
Posterior Epidural Migration of a Lumbar Disc Herniation Causing Cauda Equina Syndrome: A Case Report. ( 30087815 )
2018
41
Epidural venous plexus engorgement due to inferior vena cava thrombosis resulting in cauda equina syndrome: Case report and literature review. ( 30105127 )
2018
42
Surgical Intervention for Cauda Equina Syndrome in the Second and Third Trimesters of Pregnancy: A Report of Three Cases. ( 30211711 )
2018
43
The clinical features and outcome of scan-negative and scan-positive cases in suspected cauda equina syndrome: a retrospective study of 276 patients. ( 30298195 )
2018
44
Bladder Recovery Patterns in Patients with Complete Cauda Equina Syndrome: A Single-Center Study. ( 30322260 )
2018
45
Lumbar Intraspinal Osteolipoma Presenting as Cauda Equina Syndrome: A Case Report and Review of Literature. ( 30425872 )
2018
46
Understanding cauda equina syndrome: protocol for a UK multicentre prospective observational cohort study. ( 30552283 )
2018
47
Operative Management of Perinatal Lumbar Disc Herniation and Cauda Equina Syndrome: A Case Series ( 30560639 )
2018
48
Non-compressive postoperative cauda equina syndrome following decompression and transforaminal interbody fusion surgery. ( 30567132 )
2018
49
Limbus Vertebral Fracture Presenting as Cauda Equina Syndrome Masquerading An Acute Disc Prolapse - A Rare Case Report and Review of Literature. ( 30687660 )
2018
50
Acute polyradiculopathy secondary to idelalisib in Relapsed Classical Hodgkin's lymphoma. ( 30191811 )
2018

Variations for Cauda Equina Syndrome

Expression for Cauda Equina Syndrome

Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for Cauda Equina Syndrome

GO Terms for Cauda Equina Syndrome

Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.33 AKR1C2 ALDH5A1 BMP2
2 glucose metabolic process GO:0006006 8.96 ALDH5A1 NISCH
3 respiratory electron transport chain GO:0022904 8.62 ALDH5A1 MT-CO3

Sources for Cauda Equina Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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