MCID: CSL001
MIFTS: 44

Causalgia

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Causalgia

MalaCards integrated aliases for Causalgia:

Name: Causalgia 12 73 53 58 54 44 15 17 70 32
Complex Regional Pain Syndrome, Type Ii 12
Complex Regional Pain Syndrome Type 2 58

Characteristics:

Orphanet epidemiological data:

58
complex regional pain syndrome type 2
Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3222
MeSH 44 D002422
NCIt 50 C121572
SNOMED-CT 67 247397004
ICD10 32 G56.4
ICD10 via Orphanet 33 G90.6
UMLS via Orphanet 71 C0007462
Orphanet 58 ORPHA99994
UMLS 70 C0007462

Summaries for Causalgia

NINDS : 53 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Causalgia, also known as complex regional pain syndrome, type ii, is related to complex regional pain syndrome and algoneurodystrophy, and has symptoms including sciatica and neuralgia. An important gene associated with Causalgia is TACR1 (Tachykinin Receptor 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Calcium signaling pathway. The drugs Etoricoxib and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cortex and dorsal root ganglion, and related phenotypes are behavior/neurological and integument

Wikipedia : 73 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), describes an... more...

Related Diseases for Causalgia

Diseases related to Causalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 complex regional pain syndrome 31.4 TACR1 TAC1 SCN9A CALCA
2 algoneurodystrophy 30.5 TAC1 NGF CALCA
3 reflex sympathetic dystrophy 30.0 TRPV1 TAC1 RPIA P2RX3 CALCA
4 mononeuropathy 29.8 TRPV1 TAC1 NGF
5 neuroma 29.6 TRPV1 SCN10A NGF CALCA
6 erythromelalgia 29.4 TRPV1 SCN9A SCN11A SCN10A
7 neuropathy 28.5 TRPV1 SCN9A SCN11A SCN10A NGF
8 peripheral nervous system disease 28.0 TRPV1 TAC1 SCN9A SCN11A SCN10A NGF
9 paine syndrome 27.7 TRPV1 TACR1 TAC1 SCN9A SCN11A SCN10A
10 neurotrophic keratopathy 10.3 TACR1 TAC1
11 keratopathy 10.2 TACR1 TAC1
12 carbamazepine allergy 10.2 TAC1 CALCA
13 taylor's syndrome 10.2 TAC1 CALCA
14 telogen effluvium 10.2 TACR1 TAC1
15 perianal hematoma 10.2 TAC1 CALCA
16 horner's syndrome 10.2
17 plantar fasciitis 10.2 TAC1 CALCA
18 retinitis pigmentosa 67 10.2 TACR1 TAC1
19 hyperhidrosis, gustatory 10.2 TRPV1 TAC1
20 bursitis 10.2 TAC1 CALCA
21 motion sickness 10.1 TACR1 TAC1
22 facial dermatosis 10.1 TRPV1 TAC1
23 pseudopterygium 10.1 TRPV1 TAC1
24 autonomic dysfunction 10.1
25 carpal tunnel syndrome 10.1
26 infective endocarditis 10.1
27 endocarditis 10.1
28 amenorrhea 10.1
29 plexopathy 10.1
30 compartment syndrome 10.1
31 intermediate coronary syndrome 10.1
32 aneurysm 10.1
33 dental pulp disease 10.1 TRPV1 TAC1
34 heart septal defect 10.1
35 eating disorder 10.1
36 epicondylitis 10.1 TACR1 TAC1 CALCA
37 chronic spontaneous urticaria 10.1 TACR1 TAC1
38 aspiration pneumonia 10.1 TRPV1 TAC1
39 vasomotor rhinitis 10.0 TRPV1 TAC1 CALCA
40 generalized epilepsy with febrile seizures plus, type 2 10.0 SCN9A SCN11A
41 dystonia 10.0
42 raynaud phenomenon 10.0
43 chronic pain 10.0
44 paresthesia 10.0
45 tremor 10.0
46 prurigo nodularis 9.9 TAC1 NGF
47 degenerative disc disease 9.9 TRPV1 CALCA
48 punctate epithelial keratoconjunctivitis 9.9 TAC1 NGF
49 lesion of sciatic nerve 9.9 TRPV1 NGF
50 cough variant asthma 9.9 TRPV1 NGF

Graphical network of the top 20 diseases related to Causalgia:



Diseases related to Causalgia

Symptoms & Phenotypes for Causalgia

UMLS symptoms related to Causalgia:


sciatica; neuralgia

MGI Mouse Phenotypes related to Causalgia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 NGF P2RX3 SCN10A SCN11A SCN9A TAC1
2 integument MP:0010771 9.23 NGF P2RX3 SCN10A SCN11A SCN9A TAC1

Drugs & Therapeutics for Causalgia

Drugs for Causalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 2 202409-33-4 123619
2 Analgesics, Non-Narcotic Phase 2
3 Cyclooxygenase 2 Inhibitors Phase 2
4 Analgesics Phase 2
5 Antirheumatic Agents Phase 2
6 Cyclooxygenase Inhibitors Phase 2
7 Anti-Inflammatory Agents Phase 2
8 Anti-Inflammatory Agents, Non-Steroidal Phase 2
9 Neurotropin Phase 2
10 Adjuvants, Immunologic Phase 2
11 Immunologic Factors Phase 2
12 Anticonvulsants Phase 2
13
parecoxib Approved 198470-84-7
14 Anesthetics
15 Anti-Anxiety Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Restore Claims Characterization Study Completed NCT00200122 Phase 4
2 Surgical Treatment of Complex Regional Pain Syndrome Type II (CRPS II) by Regional Subcutaneous Venous Sympathectomy Unknown status NCT01392599 Phase 3
3 Efficacy of Etoricoxib in Patients With Neuropathic Pain With and Without Peripheral Hyperalgesia - A Prove of Concept Trial Terminated NCT01088256 Phase 2 Etoricoxib;placebo
4 Neurotropin for Acute Dental Pain and for Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
5 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
6 The Efficacy of Motor Cortex Stimulation for Pain Control Completed NCT00462566
7 Regional Anesthesia in Combat Trauma Improves Pain Disability Outcomes Completed NCT00431847
8 Trialing of Intra-spinal Stimulation in Patients With Complex Regional Pain Syndrome or Causalgia Recruiting NCT03954080
9 An Observational Cohort Study to Assess the Long Term Effectiveness of Dorsal Root Ganglion Stimulation for Chronic Pain in the Upper Limb(s) Recruiting NCT02553876
10 Efficiacy of the Selctive COX-2-inhibitor Parecoxibe on the Pathological Low Pressure Pain Threshold (PPT) of Patients With Complex Regional Pain Syndrome (CRPS) No longer available NCT01523379 Parecoxib;Placebo
11 Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy in the Complex Regional Pain Syndrome of the Upper Limb : a Multicentric Randomized Open Study. Terminated NCT02667717
12 The Effect of Transcranial Direct Current Stimulation (t-DCS) On the P300 Component of Event-Related Potentials in Patients With Chronic Neuropathic Pain Due To Complex Regional Pain Syndrome (CRPS) or Diabetic Neuropathy-A PILOT, DOUBLE-BLIND, SHAM-CONTROLLED, CROSS-OVER STUDY Withdrawn NCT00815932

Search NIH Clinical Center for Causalgia

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Tolazoline
Tolazoline Hydrochloride

Cochrane evidence based reviews: causalgia

Genetic Tests for Causalgia

Anatomical Context for Causalgia

MalaCards organs/tissues related to Causalgia:

40
Spinal Cord, Cortex, Dorsal Root Ganglion, Brain, Skin, Tongue, Pituitary

Publications for Causalgia

Articles related to Causalgia:

(show top 50) (show all 580)
# Title Authors PMID Year
1
A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II. 54 61
12855316 2003
2
The Effectiveness of Dorsal Root Ganglion Neurostimulation for the Treatment of Chronic Pelvic Pain and Chronic Neuropathic Pain of the Lower Extremity: A Comprehensive Review of the Published Data. 61
33260203 2021
3
[Fire needling stripping after local anesthesia for verruca vulgaris: a multi-center randomized controlled trial]. 61
33559445 2021
4
Silas Weir Mitchell, MD, LLD, FRC: Neurological Evaluation and Rehabilitation of the Injured Upper Extremity. 61
31014111 2021
5
Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine. 61
33393601 2020
6
Complex regional pain syndrome type II after a brachial plexus and C6 nerve root injury. 61
32603399 2020
7
Effectiveness and Safety of Dorsal Root Ganglion Stimulation for the Treatment of Chronic Pain: A Pooled Analysis. 61
31730273 2020
8
A case report of wireless peripheral nerve stimulation for complex regional pain syndrome type-I of the upper extremity: 1 year follow up. 61
31442205 2019
9
Neuromodulation of the Dorsal Root Ganglion for Chronic Postsurgical Pain. 61
31152174 2019
10
A mysterious case of complex regional pain syndrome in a 9-year-old girl. 61
29216768 2019
11
Complex regional pain syndrome - False hopes and miscommunications. 61
30639650 2019
12
The Role of the Peripheral Nerve Surgeon in the Treatment of Pain. 61
30542905 2019
13
Complex regional pain syndrome type II arising from a gunshot wound (GSW) associated with infective endocarditis and aortic valve replacement. 61
30333197 2018
14
The modified transforaminal endoscopic technique in treating intracanalicular combining foraminal and/or extraforaminal lumbar disc herniations. 61
30505722 2018
15
Wireless peripheral nerve stimulation for complex regional pain syndrome type I of the upper extremity: a case illustration introducing a novel technology. 61
29794269 2018
16
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. 61
29316194 2018
17
Efficacy and Safety of Lidocaine Infusion Treatment for Neuropathic Pain: A Randomized, Double-Blind, and Placebo-Controlled Study. 61
29381569 2018
18
Complex regional pain syndrome type II after cervical transforaminal epidural injection: A case report. 61
29768371 2018
19
Motor-Evoked Potential Analysis of Femoral Nerve Status During the Direct Anterior Approach for Total Hip Arthroplasty. 61
29613926 2018
20
The Efficacy and Safety of Dorsal Root Ganglion Stimulation as a Treatment for Neuropathic Pain: A Literature Review. 61
28960653 2018
21
The Use of Ultrasonography to Identify the Intersection of the Dorsomedial Cutaneous Nerve of the Hallux and the Extensor Hallucis Longus Tendon: A Cadaveric Study. 61
29331290 2018
22
Jules Tinel (1879-1952): Beyond the eponym, the man and his forgotten neurological contributions. 61
28377088 2017
23
Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial. 61
28030470 2017
24
Infraorbital Nerve Decompression for Infraorbital Neuralgia/Causalgia following Blowout Orbital Fractures: A Case Series. 61
28210404 2017
25
Effect of Botulinum Toxin on Disabling Neuropathic Pain: A Case Presentation Suggesting a New Therapeutic Strategy. 61
27810581 2017
26
Ultrasonography-guided pulsed radiofrequency of sciatic nerve for the treatment of complex regional pain syndrome Type II. 61
28217060 2017
27
LETM presented with causalgia and ensued by sudden death. 61
28109254 2017
28
[Spinal cord stimulation in 62 patients: Retrospective evaluation]. 61
28467566 2017
29
Reduction in mechanical allodynia in complex regional pain syndrome patients with ultrasound-guided pulsed radiofrequency treatment of the superficial peroneal nerve. 61
27738506 2016
30
Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection. 61
27651875 2016
31
Severe Pain and Edema due to a Widespread Lymphangioma: Disappearance of Symptoms and Reduction of Lesion with Spinal Cord Stimulation. 61
27402439 2016
32
Systemic Intravenous Lidocaine for the Treatment of Complex Regional Pain Syndrome: A Case Report and Literature Review. 61
26398854 2016
33
Silas Weir Mitchell and "The Strange Case of George Dedlow". 61
27364258 2016
34
Steroid atrophy scarring treated with fat grafting in a patient with complex regional pain syndrome: A case report. 61
26735938 2016
35
Pain Relief in CRPS-II after Spinal Cord and Motor Cortex Simultaneous Dual Stimulation. 61
27228530 2016
36
Neuralgias of the Head: Occipital Neuralgia. 61
27051229 2016
37
[Spinal cord stimulation in the treatment of chronic pain syndromes]. 61
27070257 2016
38
[The Berlin diagnostic algorithm for painful knee TKA]. 61
26679494 2016
39
A Novel Mini-invasive Approach to the Treatment of Neuropathic Pain: The PENS Study. 61
26752480 2016
40
Silas Weir Mitchell: Neurologists and Neurology during the American Civil War. 61
27035676 2016
41
Publications on Peripheral Nerve Injuries during World War I: A Dramatic Increase in Knowledge. 61
27035152 2016
42
Case study: Gluteal compartment syndrome as a cause of lumbosacral radiculoplexopathy and complex regional pain syndrome. 61
27533628 2016
43
Stellate ganglion pulsed radiofrequency ablation for stretch induced complex regional pain syndrome type II. 61
26543471 2015
44
[COMPLEX REGIONAL PAIN SYNDROME]. 61
26749953 2015
45
Surgical animal models of neuropathic pain: Pros and Cons. 61
24831263 2015
46
From Mitchell's causalgia to complex regional pain syndromes: 150 years of definitions and theories. 61
25786040 2015
47
Complex regional pain syndrome (CRPS) type I: historical perspective and critical issues. 61
27134625 2015
48
The complex regional pain syndrome. 61
26563805 2015
49
Complex Regional Pain Syndrome Type II Secondary to Endovascular Aneurysm Repair. 61
25650247 2015
50
How was the Turin Shroud Man crucified? 61
25457335 2014

Variations for Causalgia

Expression for Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for Causalgia

Pathways related to Causalgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.14 TACR1 TAC1 SCN9A SCN11A SCN10A
2 12.01 TACR1 P2RX3 NGF
3 11.79 TACR1 TAC1 NGF
4
Show member pathways
11.64 SCN9A SCN11A SCN10A
5 11.56 SCN9A SCN11A SCN10A NGF CALCA
6
Show member pathways
11.31 SCN9A SCN11A SCN10A
7 10.94 TRPV1 NGF
8 10.61 SCN9A SCN11A SCN10A
9 10.17 TACR1 TAC1

GO Terms for Causalgia

Cellular components related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.56 TRPV1 SCN9A P2RX3 CALCA
2 neuronal cell body GO:0043025 9.46 TRPV1 TAC1 P2RX3 CALCA
3 axon GO:0030424 9.17 TAC1 SCN9A SCN11A SCN10A P2RX3 NGF
4 voltage-gated sodium channel complex GO:0001518 9.13 SCN9A SCN11A SCN10A

Biological processes related to Causalgia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.92 TRPV1 SCN9A SCN11A SCN10A P2RX3
2 transmembrane transport GO:0055085 9.91 TRPV1 SCN9A SCN11A SCN10A
3 ion transmembrane transport GO:0034220 9.85 TRPV1 SCN9A SCN10A P2RX3
4 regulation of ion transmembrane transport GO:0034765 9.77 SCN9A SCN11A SCN10A
5 inflammatory response GO:0006954 9.77 TRPV1 TACR1 TAC1 SCN9A CALCA
6 sodium ion transport GO:0006814 9.75 SCN9A SCN11A SCN10A
7 sodium ion transmembrane transport GO:0035725 9.73 SCN9A SCN11A SCN10A
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.71 TRPV1 TACR1 TAC1 CALCA
9 cation transmembrane transport GO:0098655 9.69 SCN9A SCN10A P2RX3
10 response to heat GO:0009408 9.63 TRPV1 P2RX3 CALCA
11 cellular response to nerve growth factor stimulus GO:1990090 9.61 TRPV1 TAC1 CALCA
12 cellular response to ATP GO:0071318 9.59 TRPV1 P2RX3
13 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.58 TRPV1 CALCA
14 negative regulation of heart rate GO:0010459 9.57 TRPV1 TAC1
15 tachykinin receptor signaling pathway GO:0007217 9.54 TACR1 TAC1
16 membrane depolarization during action potential GO:0086010 9.5 SCN9A SCN11A SCN10A
17 urinary bladder smooth muscle contraction GO:0014832 9.49 TRPV1 P2RX3
18 detection of abiotic stimulus GO:0009582 9.48 TACR1 TAC1
19 sensory perception of pain GO:0019233 9.46 TRPV1 TAC1 SCN9A SCN10A
20 behavioral response to pain GO:0048266 9.43 TRPV1 SCN9A P2RX3
21 neuronal action potential GO:0019228 9.26 SCN9A SCN11A SCN10A P2RX3
22 response to pain GO:0048265 8.92 TRPV1 TACR1 TAC1 CALCA

Molecular functions related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.5 SCN9A SCN11A SCN10A
2 sodium channel activity GO:0005272 9.43 SCN9A SCN11A SCN10A
3 ion channel activity GO:0005216 9.35 TRPV1 SCN9A SCN11A SCN10A P2RX3
4 voltage-gated sodium channel activity GO:0005248 9.33 SCN9A SCN11A SCN10A
5 cation channel activity GO:0005261 8.92 TRPV1 SCN9A SCN11A SCN10A

Sources for Causalgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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