MCID: CSL001
MIFTS: 46

Causalgia

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Causalgia

MalaCards integrated aliases for Causalgia:

Name: Causalgia 12 76 54 59 55 44 15 73
Complex Regional Pain Syndrome, Type Ii 12
Complex Regional Pain Syndrome Type 2 59

Characteristics:

Orphanet epidemiological data:

59
complex regional pain syndrome type 2
Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3222
MeSH 44 D002422
NCIt 50 C121572
SNOMED-CT 68 66056001
Orphanet 59 ORPHA99994
UMLS via Orphanet 74 C0007462
ICD10 via Orphanet 34 G56.4
ICD10 33 G56.4
UMLS 73 C0007462

Summaries for Causalgia

NINDS : 54 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Causalgia, also known as complex regional pain syndrome, type ii, is related to reflex sympathetic dystrophy and algoneurodystrophy, and has symptoms including sciatica and neuralgia. An important gene associated with Causalgia is SCN11A (Sodium Voltage-Gated Channel Alpha Subunit 11), and among its related pathways/superpathways are Neuroscience and Activation of TRKA receptors. The drugs Etoricoxib and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and spinal cord, and related phenotype is behavior/neurological.

Wikipedia : 76 Complex Regional Pain Syndrome (CRPS), also known as Reflex Sympathetic Dystrophy (RSD), is a disorder... more...

Related Diseases for Causalgia

Diseases related to Causalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 reflex sympathetic dystrophy 32.7 CALCA NPS NPY
2 algoneurodystrophy 32.6 CALCA NGF
3 complex regional pain syndrome 32.6 CALCA NPY TAC1
4 sodium channelopathy-related small fiber neuropathy 10.3 SCN10A SCN11A
5 neuroschistosomiasis 10.3 NGF TAC1
6 burn scar 10.3 CALCA TAC1
7 erythermalgia, primary 10.3 SCN10A SCN11A
8 indifference to pain, congenital, autosomal recessive 10.3 SCN10A SCN11A
9 prurigo nodularis 10.2 NGF TAC1
10 vasomotor rhinitis 10.2 CALCA TAC1
11 lesion of sciatic nerve 10.2 NGF SCN10A
12 paroxysmal extreme pain disorder 10.2 SCN10A SCN11A
13 leprosy 2 10.2 CALCA NPY
14 epicondylitis 10.2 NPS TAC1
15 dental pulp disease 10.2 NPS SCN11A TAC1
16 prolactin producing pituitary tumor 10.2 CALCA NGF NTRK1
17 brachial plexus lesion 10.2 CALCA GDNF TAC1
18 spinocerebellar ataxia, autosomal recessive 10 10.2 IFNA2 SCN10A
19 pancreatic somatostatinoma 10.2 CALCA ENO2
20 stereotypic movement disorder 10.1 NPY TAC1
21 duodenal somatostatinoma 10.1 CALCA ENO2
22 lung oat cell carcinoma 10.1 CALCA ENO2
23 atypical follicular adenoma 10.1 CALCA ENO2
24 neurotrophic keratopathy 10.1 TAC1 TACR1
25 indeterminate leprosy 10.1 NPS NPY TAC1
26 epispadias 10.1 CALCA NPY
27 paine syndrome 10.1 NGF SCN10A SCN11A TAC1
28 dystonia 10.1
29 erythromelalgia 10.1
30 diffuse pulmonary fibrosis 10.1 CALCA ENO2 TAC1
31 diabetic neuropathy 10.1 GDNF NGF NTRK1
32 spinocerebellar ataxia 23 10.1 NPS TACR1
33 acute thyroiditis 10.1 CALCA ENO2
34 conjunctival nevus 10.1 NGF NTRK1
35 cerebral neuroblastoma 10.1 ENO2 NGF
36 autonomic neuropathy 10.1 NGF NPY NTRK1
37 monoclonal paraproteinemia 10.1 CD27 PRTN3
38 askin's tumor 10.0 ENO2 NGF NTRK1
39 nervous system disease 10.0 ENO2 GDNF NGF
40 retinitis pigmentosa 68 10.0 NPS TAC1 TACR1
41 neuropathy, hereditary sensory and autonomic, type v 10.0 NGF NTRK1
42 autonomic nervous system neoplasm 10.0 ENO2 NGF NTRK1
43 perry syndrome 10.0 NPS TAC1 TACR1
44 peripheral nervous system neoplasm 10.0 ENO2 NGF NTRK1
45 cystitis 10.0 NGF TAC1 TACR1
46 autonomic nervous system benign neoplasm 10.0 ENO2 NTRK1
47 cloacogenic carcinoma 10.0 CALCA CD27 ENO2 NPS
48 autonomic nervous system disease 10.0 CALCA NGF NPS NPY TAC1
49 migraine with or without aura 1 10.0 CALCA NPS TAC1 TACR1
50 burns 10.0

Graphical network of the top 20 diseases related to Causalgia:



Diseases related to Causalgia

Symptoms & Phenotypes for Causalgia

UMLS symptoms related to Causalgia:


sciatica, neuralgia

MGI Mouse Phenotypes related to Causalgia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.32 ENO2 GDNF NGF NPY NTRK1 SCN10A

Drugs & Therapeutics for Causalgia

Drugs for Causalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 2 202409-33-4 123619
2 Peripheral Nervous System Agents Phase 2
3 Analgesics Phase 2
4 Analgesics, Non-Narcotic Phase 2
5 Cyclooxygenase Inhibitors Phase 2
6 Cyclooxygenase 2 Inhibitors Phase 2
7 Anti-Inflammatory Agents, Non-Steroidal Phase 2
8 Anti-Inflammatory Agents Phase 2
9 Antirheumatic Agents Phase 2
10 Adjuvants, Immunologic Phase 2
11 Immunologic Factors Phase 2
12 Neurotropin Phase 2
13 Anticonvulsants Phase 2
14
Lidocaine Approved, Vet_approved 137-58-6 3676
15
Parecoxib Approved 198470-84-7
16 Diuretics, Potassium Sparing
17 Central Nervous System Depressants
18 Anesthetics, Local
19 Sodium Channel Blockers
20 Anti-Arrhythmia Agents
21 Anesthetics
22 Anti-Anxiety Agents

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Restore Claims Characterization Study Completed NCT00200122 Phase 4
2 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
3 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
4 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
5 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
6 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
7 Exposure Therapy Combined With Cortical Interventions for CRPS-II Completed NCT03174249 Not Applicable
8 Evoked Fields After Median and Ulnar Stimulation Completed NCT00217243
9 A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain Completed NCT01923285 Not Applicable
10 Regional Anesthesia Military Battlefield Pain Outcomes Study Completed NCT00431847
11 The Efficacy of Motor Cortex Stimulation for Pain Control Completed NCT00462566 Not Applicable
12 Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy Recruiting NCT02667717 Not Applicable
13 Dorsal Root Ganglion Stimulation for Hand and Upper Limb Pain Recruiting NCT02553876
14 Comparison of Dorsal Column Stimulation to Dorsal Root Ganglion Stimulation for Complex Regional Pain Syndrome Not yet recruiting NCT03794024
15 Development and Validation of New "SNU Illustrated Pain Rating Scale" as a Tool for Postoperative Pain Assessment Not yet recruiting NCT03764046
16 Efficacy of Parecoxib on Patients With CRPS No longer available NCT01523379 Parecoxib;Placebo
17 Study of Proteins Associated With Complex Regional Pain Syndrome Terminated NCT00033969
18 The Effect of Transcranial Direct Current Stimulation (t-DCS) On the P300 Component of Event-Related Potentials in Patients With Chronic Neuropathic Pain Due To CRPS or Diabetic Neuropathy Withdrawn NCT00815932 Not Applicable

Search NIH Clinical Center for Causalgia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: causalgia

Genetic Tests for Causalgia

Anatomical Context for Causalgia

MalaCards organs/tissues related to Causalgia:

41
Skin, Bone, Spinal Cord, Pituitary, Lung, Colon, Thyroid

Publications for Causalgia

Articles related to Causalgia:

(show top 50) (show all 213)
# Title Authors Year
1
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. ( 29316194 )
2018
2
Complex regional pain syndrome type II after cervical transforaminal epidural injection: A case report. ( 29768371 )
2018
3
Complex regional pain syndrome type II arising from a gunshot wound (GSW) associated with infective endocarditis and aortic valve replacement. ( 30333197 )
2018
4
Infraorbital Nerve Decompression for Infraorbital Neuralgia/Causalgia following Blowout Orbital Fractures: A Case Series. ( 28210404 )
2017
5
Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial. ( 28030470 )
2017
6
LETM presented with causalgia and ensued by sudden death. ( 28109254 )
2017
7
Ultrasonography-guided pulsed radiofrequency of sciatic nerve for the treatment of complex regional pain syndrome Type II. ( 28217060 )
2017
8
Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection. ( 27651875 )
2016
9
Stellate ganglion pulsed radiofrequency ablation for stretch induced complex regional pain syndrome type II. ( 26543471 )
2015
10
From Mitchell's causalgia to complex regional pain syndromes: 150 years of definitions and theories. ( 25786040 )
2015
11
Complex Regional Pain Syndrome Type II Secondary to Endovascular Aneurysm Repair. ( 25650247 )
2015
12
Nerve resection, crush and re-location relieve complex regional pain syndrome type II: a case report. ( 24502845 )
2014
13
Free flap transfer for complex regional pain syndrome type II. ( 27252946 )
2014
14
Upregulation of I+1-adrenoceptors on cutaneous nerve fibres after partial sciatic nerve ligation and in complex regional pain syndrome type II. ( 24342464 )
2013
15
Surgical treatment of complex regional pain syndrome type II with regional subcutaneous venous sympathectomy. ( 22695435 )
2012
16
MRI findings of causalgia of the lower extremity following transsphenoidal resection of pituitary tumor. ( 23008790 )
2012
17
Lower extremity complex regional pain syndrome type II after a craniotomy: case report. ( 21911198 )
2011
18
Complex regional pain syndrome type II associated with lumbosacral plexopathy: a case report. ( 21134122 )
2010
19
Median Nerve Stimulation in a Patient with Complex Regional Pain Syndrome Type II. ( 19844632 )
2009
20
Causalgia: a restatement. ( 19927072 )
2009
21
Mirror therapy in patients with causalgia (complex regional pain syndrome type II) following peripheral nerve injury: two cases. ( 18382828 )
2008
22
The outcome of percutaneous computed tomography-guided chemical lumbar sympathectomy for patients with causalgia after lumbar discectomy. ( 17825373 )
2008
23
Nerve resection and re-location may relieve causalgia: a case report. ( 17869421 )
2007
24
Causalgia: an unknown contribution. ( 20503746 )
2006
25
Surgical relief of causalgia with an artificial nerve guide tube: Successful surgical treatment of causalgia (Complex Regional Pain Syndrome Type II) by in situ tissue engineering with a polyglycolic acid-collagen tube. ( 16153773 )
2005
26
Amenorrhea in a patient after treatment with gabapentin for complex regional pain syndrome type II. ( 15100596 )
2004
27
Silas Weir Mitchell, MD: the physician who discovered causalgia. ( 15043886 )
2004
28
Reflex sympathetic dystrophy and causalgia. ( 16106603 )
2004
29
Complex regional pain syndrome: redefining reflex sympathetic dystrophy and causalgia. ( 20086409 )
2004
30
A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II. ( 12855316 )
2003
31
Causalgia: a meta-analysis of the literature. ( 14609871 )
2003
32
Great auricular causalgia: an unusual complication of excision of the submandibular gland. ( 14581027 )
2003
33
The rehabilitation of causalgia (complex regional pain syndrome-type II). ( 11878079 )
2002
34
Thoracoscopic sympathectomy in causalgia. ( 11695793 )
2001
35
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. ( 10870738 )
2000
36
Sympathectomy for causalgia: experience with military injuries. ( 10963537 )
2000
37
Venipuncture-induced causalgia: anatomic relations of upper extremity superficial veins and nerves, and clinical considerations. ( 10988302 )
2000
38
Soleus H-reflex tests in causalgia-dystonia compared with dystonia and mimicked dystonic posture. ( 10599808 )
1999
39
Causalgia, pathological pain, and adrenergic receptors. ( 10393877 )
1999
40
Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? ( 10366221 )
1999
41
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. ( 9841006 )
1998
42
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. ( 9549444 )
1998
43
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Stellate ganglion blockage: clinics take precautions, but few follow guidelines. ( 9841007 )
1998
44
Case report: Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. ( 9516712 )
1998
45
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Terminology is outdated-1994 taxonomy should be used. ( 9732355 )
1998
46
Traumatic neuralgias: complex regional pain syndromes (reflex sympathetic dystrophy and causalgia): clinical characteristics, pathophysiological mechanisms and therapy. ( 9767066 )
1998
47
Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. ( 9107464 )
1997
48
Complex regional pain syndromes: including "reflex sympathetic dystrophy" and "causalgia". ( 9127652 )
1997
49
Algodystrophy (reflex sympathetic dystrophy syndrome) and causalgia: novel concepts regarding the nosology, pathophysiology, and pathogenesis of complex regional pain syndromes. Is the sympathetic hyperactivity hypothesis wrong? ( 9338930 )
1997
50
Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. A case report. ( 9055376 )
1997

Variations for Causalgia

Expression for Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for Causalgia

Pathways related to Causalgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.76 CALCA ENO2 NGF NPY NTRK1 SCN10A
2
Show member pathways
10.2 NGF NTRK1
3 9.8 TAC1 TACR1

GO Terms for Causalgia

Cellular components related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 CALCA ENO2 IFNA2 NGF NPY PRTN3
2 extracellular region GO:0005576 9.61 CALCA CD27 GDNF IFNA2 NGF NPS
3 voltage-gated sodium channel complex GO:0001518 9.26 SCN10A SCN11A
4 axon GO:0030424 9.1 CALCA NGF NTRK1 SCN10A SCN11A TAC1

Biological processes related to Causalgia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.92 CD27 GDNF NGF NTRK1 UBC
2 regulation of signaling receptor activity GO:0010469 9.85 CALCA GDNF IFNA2 NGF NPY
3 regulation of blood pressure GO:0008217 9.58 CALCA NPY TAC1
4 neurotrophin TRK receptor signaling pathway GO:0048011 9.57 NGF NTRK1
5 positive regulation of Ras protein signal transduction GO:0046579 9.56 NGF NTRK1
6 membrane depolarization during action potential GO:0086010 9.55 SCN10A SCN11A
7 sympathetic nervous system development GO:0048485 9.54 GDNF NTRK1
8 sensory perception of pain GO:0019233 9.54 NTRK1 SCN10A TAC1
9 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.51 CALCA NTRK1
10 nerve growth factor signaling pathway GO:0038180 9.49 NGF NTRK1
11 positive regulation of synaptic transmission, GABAergic GO:0032230 9.48 NPS TAC1
12 tachykinin receptor signaling pathway GO:0007217 9.43 TAC1 TACR1
13 cellular response to nerve growth factor stimulus GO:1990090 9.33 CALCA NTRK1 TAC1
14 positive regulation of action potential GO:0045760 9.32 NPS TAC1
15 detection of abiotic stimulus GO:0009582 9.26 TAC1 TACR1
16 neuropeptide signaling pathway GO:0007218 9.26 CALCA NPS NPY TAC1
17 response to pain GO:0048265 8.8 CALCA TAC1 TACR1

Molecular functions related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.1 CALCA GDNF NGF NPY PRTN3 TAC1
2 voltage-gated sodium channel activity GO:0005248 8.96 SCN10A SCN11A

Sources for Causalgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....