MCID: CSL001
MIFTS: 41

Causalgia

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Causalgia

MalaCards integrated aliases for Causalgia:

Name: Causalgia 12 77 55 60 56 45 15 17 74
Complex Regional Pain Syndrome, Type Ii 12
Complex Regional Pain Syndrome Type 2 60

Characteristics:

Orphanet epidemiological data:

60
complex regional pain syndrome type 2
Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3222
MeSH 45 D002422
NCIt 51 C121572
SNOMED-CT 69 66056001
ICD10 34 G56.4
ICD10 via Orphanet 35 G56.4
UMLS via Orphanet 75 C0007462
Orphanet 60 ORPHA99994
UMLS 74 C0007462

Summaries for Causalgia

NINDS : 55 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Causalgia, also known as complex regional pain syndrome, type ii, is related to reflex sympathetic dystrophy and complex regional pain syndrome, and has symptoms including sciatica and neuralgia. An important gene associated with Causalgia is RPIA (Ribose 5-Phosphate Isomerase A), and among its related pathways/superpathways are AMPK Enzyme Complex Pathway and Monoamine GPCRs. The drugs Etoricoxib and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and dorsal root ganglion.

Wikipedia : 77 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a disorder... more...

Related Diseases for Causalgia

Diseases related to Causalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 reflex sympathetic dystrophy 11.7
2 complex regional pain syndrome 11.6
3 algoneurodystrophy 11.5
4 dystonia 10.1
5 erythromelalgia 10.1
6 burns 10.0
7 meningococcal meningitis 10.0
8 horner's syndrome 10.0
9 biliary dyskinesia 10.0
10 pancreatitis 10.0
11 meningitis 10.0
12 pain - chronic 10.0
13 dysautonomia 10.0
14 infective endocarditis 9.9
15 endocarditis 9.9
16 amenorrhea 9.9
17 plexopathy 9.9

Graphical network of the top 20 diseases related to Causalgia:



Diseases related to Causalgia

Symptoms & Phenotypes for Causalgia

UMLS symptoms related to Causalgia:


sciatica, neuralgia

Drugs & Therapeutics for Causalgia

Drugs for Causalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 2 202409-33-4 123619
2 Peripheral Nervous System Agents Phase 2
3 Analgesics Phase 2
4 Antirheumatic Agents Phase 2
5 Analgesics, Non-Narcotic Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 2
7 Cyclooxygenase 2 Inhibitors Phase 2
8 Cyclooxygenase Inhibitors Phase 2
9 Anti-Inflammatory Agents Phase 2
10 Adjuvants, Immunologic Phase 2
11 Neurotropin Phase 2
12 Immunologic Factors Phase 2
13 Anticonvulsants Phase 2
14
Lidocaine Approved, Vet_approved 137-58-6 3676
15
Parecoxib Approved 198470-84-7
16 Central Nervous System Depressants
17 Anti-Arrhythmia Agents
18 Sodium Channel Blockers
19 Anesthetics
20 Anesthetics, Local
21 Diuretics, Potassium Sparing
22 Anti-Anxiety Agents

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Restore Claims Characterization Study Completed NCT00200122 Phase 4
2 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
3 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Enrolling by invitation NCT02987855 Phase 1, Phase 2
4 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
5 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
6 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
7 Exposure Therapy Combined With Cortical Interventions for CRPS-II Completed NCT03174249 Not Applicable
8 Evoked Fields After Median and Ulnar Stimulation Completed NCT00217243
9 A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain Completed NCT01923285 Not Applicable
10 Regional Anesthesia Military Battlefield Pain Outcomes Study Completed NCT00431847
11 The Efficacy of Motor Cortex Stimulation for Pain Control Completed NCT00462566 Not Applicable
12 Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy Recruiting NCT02667717 Not Applicable
13 Dorsal Root Ganglion Stimulation for Hand and Upper Limb Pain Recruiting NCT02553876
14 Comparison of Dorsal Column Stimulation to Dorsal Root Ganglion Stimulation for Complex Regional Pain Syndrome Not yet recruiting NCT03794024
15 Development and Validation of New "SNU Illustrated Pain Rating Scale" as a Tool for Postoperative Pain Assessment Not yet recruiting NCT03764046
16 Efficacy of Parecoxib on Patients With CRPS No longer available NCT01523379 Parecoxib;Placebo
17 Study of Proteins Associated With Complex Regional Pain Syndrome Terminated NCT00033969
18 The Effect of Transcranial Direct Current Stimulation (t-DCS) On the P300 Component of Event-Related Potentials in Patients With Chronic Neuropathic Pain Due To CRPS or Diabetic Neuropathy Withdrawn NCT00815932 Not Applicable

Search NIH Clinical Center for Causalgia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: causalgia

Genetic Tests for Causalgia

Anatomical Context for Causalgia

MalaCards organs/tissues related to Causalgia:

42
Skin, Bone, Dorsal Root Ganglion, Cortex, Spinal Cord, Testes, Tongue

Publications for Causalgia

Articles related to Causalgia:

(show top 50) (show all 220)
# Title Authors Year
1
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. ( 29316194 )
2018
2
Complex regional pain syndrome type II after cervical transforaminal epidural injection: A case report. ( 29768371 )
2018
3
Complex regional pain syndrome type II arising from a gunshot wound (GSW) associated with infective endocarditis and aortic valve replacement. ( 30333197 )
2018
4
Infraorbital Nerve Decompression for Infraorbital Neuralgia/Causalgia following Blowout Orbital Fractures: A Case Series. ( 28210404 )
2017
5
LETM presented with causalgia and ensued by sudden death. ( 28109254 )
2017
6
Ultrasonography-guided pulsed radiofrequency of sciatic nerve for the treatment of complex regional pain syndrome Type II. ( 28217060 )
2017
7
Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection. ( 27651875 )
2016
8
Dorsal root ganglion stimulation yielded higher treatment success rate for CRPS and causalgia at 3 and 12 months: randomized comparative trial. ( 28030470 )
2016
9
Stellate ganglion pulsed radiofrequency ablation for stretch induced complex regional pain syndrome type II. ( 26543471 )
2015
10
From Mitchell's causalgia to complex regional pain syndromes: 150 years of definitions and theories. ( 25786040 )
2015
11
Complex Regional Pain Syndrome Type II Secondary to Endovascular Aneurysm Repair. ( 25650247 )
2015
12
Nerve resection, crush and re-location relieve complex regional pain syndrome type II: a case report. ( 24502845 )
2014
13
Free flap transfer for complex regional pain syndrome type II. ( 27252946 )
2014
14
Upregulation of I+1-adrenoceptors on cutaneous nerve fibres after partial sciatic nerve ligation and in complex regional pain syndrome type II. ( 24342464 )
2013
15
Surgical treatment of complex regional pain syndrome type II with regional subcutaneous venous sympathectomy. ( 22695435 )
2012
16
MRI findings of causalgia of the lower extremity following transsphenoidal resection of pituitary tumor. ( 23008790 )
2012
17
Lower extremity complex regional pain syndrome type II after a craniotomy: case report. ( 21911198 )
2011
18
Complex regional pain syndrome type II associated with lumbosacral plexopathy: a case report. ( 21134122 )
2010
19
Median Nerve Stimulation in a Patient with Complex Regional Pain Syndrome Type II. ( 19844632 )
2009
20
Causalgia: a restatement. ( 19927072 )
2009
21
Mirror therapy in patients with causalgia (complex regional pain syndrome type II) following peripheral nerve injury: two cases. ( 18382828 )
2008
22
The outcome of percutaneous computed tomography-guided chemical lumbar sympathectomy for patients with causalgia after lumbar discectomy. ( 17825373 )
2008
23
Nerve resection and re-location may relieve causalgia: a case report. ( 17869421 )
2007
24
Management of complex regional pain syndrome type II using lidoderm 5% patches. ( 17251215 )
2007
25
Causalgia: an unknown contribution. ( 20503746 )
2006
26
Transcutaneous electrical nerve stimulation for the management of neuropathic pain: the effects of frequency and electrode position on prevention of allodynia in a rat model of complex regional pain syndrome type II. ( 16649893 )
2006
27
Surgical relief of causalgia with an artificial nerve guide tube: Successful surgical treatment of causalgia (Complex Regional Pain Syndrome Type II) by in situ tissue engineering with a polyglycolic acid-collagen tube. ( 16153773 )
2005
28
Nerve decompression for complex regional pain syndrome type II following upper extremity surgery. ( 15680558 )
2005
29
Amenorrhea in a patient after treatment with gabapentin for complex regional pain syndrome type II. ( 15100596 )
2004
30
Silas Weir Mitchell, MD: the physician who discovered causalgia. ( 15043886 )
2004
31
Reflex sympathetic dystrophy and causalgia. ( 16106603 )
2004
32
Complex regional pain syndrome: redefining reflex sympathetic dystrophy and causalgia. ( 20086409 )
2004
33
A case of complex regional pain syndrome type II after transradial coronary intervention. ( 15549477 )
2004
34
A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II. ( 12855316 )
2003
35
Causalgia: a meta-analysis of the literature. ( 14609871 )
2003
36
Great auricular causalgia: an unusual complication of excision of the submandibular gland. ( 14581027 )
2003
37
Motor cortex stimulation in a patient with intractable complex regional pain syndrome type II with hemibody involvement. Case report. ( 12546368 )
2003
38
The rehabilitation of causalgia (complex regional pain syndrome-type II). ( 11878079 )
2002
39
Severe complex regional pain syndrome type II after radial artery harvesting. ( 12400786 )
2002
40
Thoracoscopic sympathectomy in causalgia. ( 11695793 )
2001
41
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. ( 10870738 )
2000
42
Sympathectomy for causalgia: experience with military injuries. ( 10963537 )
2000
43
Venipuncture-induced causalgia: anatomic relations of upper extremity superficial veins and nerves, and clinical considerations. ( 10988302 )
2000
44
Soleus H-reflex tests in causalgia-dystonia compared with dystonia and mimicked dystonic posture. ( 10599808 )
1999
45
Causalgia, pathological pain, and adrenergic receptors. ( 10393877 )
1999
46
Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? ( 10366221 )
1999
47
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. ( 9841006 )
1998
48
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. ( 9549444 )
1998
49
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Stellate ganglion blockage: clinics take precautions, but few follow guidelines. ( 9841007 )
1998
50
Case report: Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. ( 9516712 )
1998

Variations for Causalgia

Expression for Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for Causalgia

GO Terms for Causalgia

Cellular components related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.13 ADRA2C CALCA SCN11A
2 integral component of postsynaptic membrane GO:0099055 8.32 ADRA1A

Biological processes related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.48 ADRA1A CALCA
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.46 ADRA1A CALCA
3 positive regulation of MAPK cascade GO:0043410 9.43 ADRA1A ADRA2C
4 cell-cell signaling GO:0007267 9.43 ADRA1A ADRA2C CALCA
5 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.4 ADRA1A ADRA2C
6 regulation of sensory perception of pain GO:0051930 9.37 ADRA2C SCN11A
7 positive regulation of vasoconstriction GO:0045907 9.32 ADRA1A ADRA2C
8 regulation of vasoconstriction GO:0019229 9.16 ADRA1A ADRA2C
9 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 8.96 ADRA1A ADRA2C
10 adrenergic receptor signaling pathway GO:0071875 8.62 ADRA1A ADRA2C

Molecular functions related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adrenergic receptor activity GO:0004935 8.62 ADRA1A ADRA2C

Sources for Causalgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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