Aliases & Classifications for Causalgia

MalaCards integrated aliases for Causalgia:

Name: Causalgia 12 76 54 59 55 44 15 73
Complex Regional Pain Syndrome, Type Ii 12
Complex Regional Pain Syndrome Type 2 59

Characteristics:

Orphanet epidemiological data:

59
complex regional pain syndrome type 2
Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3222
MeSH 44 D002422
NCIt 50 C121572
Orphanet 59 ORPHA99994
UMLS via Orphanet 74 C0007462
ICD10 via Orphanet 34 G56.4
ICD10 33 G56.4
UMLS 73 C0007462

Summaries for Causalgia

NINDS : 54 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Causalgia, also known as complex regional pain syndrome, type ii, is related to complex regional pain syndrome and reflex sympathetic dystrophy, and has symptoms including neuralgia and sciatica. An important gene associated with Causalgia is SCN11A (Sodium Voltage-Gated Channel Alpha Subunit 11), and among its related pathways/superpathways is Neuroscience. The drugs Etoricoxib and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and dorsal root ganglion.

Wikipedia : 76 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD) or... more...

Related Diseases for Causalgia

Diseases related to Causalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 complex regional pain syndrome 11.4
2 reflex sympathetic dystrophy 10.8
3 algoneurodystrophy 10.4
4 paine syndrome 10.4
5 burns 9.9
6 dystonia 9.9
7 neuronitis 9.9
8 meningococcal meningitis 9.8
9 horner's syndrome 9.8
10 biliary dyskinesia 9.8
11 pancreatitis 9.8
12 erythromelalgia 9.8
13 meningitis 9.8
14 type i 9.8
15 chronic pain 9.8
16 dysautonomia 9.8
17 pituitary tumors 9.8

Graphical network of the top 20 diseases related to Causalgia:



Diseases related to Causalgia

Symptoms & Phenotypes for Causalgia

UMLS symptoms related to Causalgia:


neuralgia, sciatica

Drugs & Therapeutics for Causalgia

Drugs for Causalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 2 202409-33-4 123619
2 Analgesics Phase 2
3 Peripheral Nervous System Agents Phase 2
4 Analgesics, Non-Narcotic Phase 2
5 Anti-Inflammatory Agents Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 2
7 Antirheumatic Agents Phase 2
8 Cyclooxygenase 2 Inhibitors Phase 2
9 Cyclooxygenase Inhibitors Phase 2
10 Adjuvants, Immunologic Phase 2
11 Anticonvulsants Phase 2
12 Neurotropin Phase 2
13
Lidocaine Approved, Vet_approved 137-58-6 3676
14
Menthol Approved Not Applicable 2216-51-5 16666
15 Parecoxib Approved 198470-84-7
16 Anesthetics
17 Anesthetics, Local
18 Anti-Arrhythmia Agents
19 Central Nervous System Depressants
20 Diuretics, Potassium Sparing
21 Sodium Channel Blockers
22 Anti-Anxiety Agents

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Restore Claims Characterization Study Completed NCT00200122 Phase 4
2 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
3 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
4 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
5 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
6 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
7 Exposure Therapy Combined With Cortical Interventions for CRPS-II Completed NCT03174249 Not Applicable
8 Evoked Fields After Median and Ulnar Stimulation Completed NCT00217243
9 A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain Completed NCT01923285 Not Applicable
10 Regional Anesthesia Military Battlefield Pain Outcomes Study Completed NCT00431847
11 The Efficacy of Motor Cortex Stimulation for Pain Control Completed NCT00462566 Not Applicable
12 Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy Recruiting NCT02667717 Not Applicable
13 Dorsal Root Ganglion Stimulation for Hand and Upper Limb Pain Recruiting NCT02553876
14 Efficacy of Parecoxib on Patients With CRPS No longer available NCT01523379 Parecoxib;Placebo
15 Study of Proteins Associated With Complex Regional Pain Syndrome Terminated NCT00033969
16 The Effect of Transcranial Direct Current Stimulation (t-DCS) On the P300 Component of Event-Related Potentials in Patients With Chronic Neuropathic Pain Due To CRPS or Diabetic Neuropathy Withdrawn NCT00815932 Not Applicable

Search NIH Clinical Center for Causalgia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: causalgia

Genetic Tests for Causalgia

Anatomical Context for Causalgia

MalaCards organs/tissues related to Causalgia:

41
Skin, Bone, Dorsal Root Ganglion, Cortex, Spinal Cord, Pituitary, Testes

Publications for Causalgia

Articles related to Causalgia:

(show top 50) (show all 200)
# Title Authors Year
1
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. ( 29316194 )
2018
2
Complex regional pain syndrome type II after cervical transforaminal epidural injection: A case report. ( 29768371 )
2018
3
Infraorbital Nerve Decompression for Infraorbital Neuralgia/Causalgia following Blowout Orbital Fractures: A Case Series. ( 28210404 )
2017
4
LETM presented with causalgia and ensued by sudden death. ( 28109254 )
2017
5
Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection. ( 27651875 )
2016
6
Dorsal root ganglion stimulation yielded higher treatment success rate for CRPS and causalgia at 3 and 12 months: randomized comparative trial. ( 28030470 )
2016
7
Stellate ganglion pulsed radiofrequency ablation for stretch induced complex regional pain syndrome type II. ( 26543471 )
2015
8
From Mitchell's causalgia to complex regional pain syndromes: 150 years of definitions and theories. ( 25786040 )
2015
9
Upregulation of I+1-adrenoceptors on cutaneous nerve fibres after partial sciatic nerve ligation and in complex regional pain syndrome type II. ( 24342464 )
2013
10
Surgical treatment of complex regional pain syndrome type II with regional subcutaneous venous sympathectomy. ( 22695435 )
2012
11
MRI findings of causalgia of the lower extremity following transsphenoidal resection of pituitary tumor. ( 23008790 )
2012
12
Lower extremity complex regional pain syndrome type II after a craniotomy: case report. ( 21911198 )
2011
13
Complex regional pain syndrome type II associated with lumbosacral plexopathy: a case report. ( 21134122 )
2010
14
Median Nerve Stimulation in a Patient with Complex Regional Pain Syndrome Type II. ( 19844632 )
2009
15
Causalgia: a restatement. ( 19927072 )
2009
16
Mirror therapy in patients with causalgia (complex regional pain syndrome type II) following peripheral nerve injury: two cases. ( 18382828 )
2008
17
The outcome of percutaneous computed tomography-guided chemical lumbar sympathectomy for patients with causalgia after lumbar discectomy. ( 17825373 )
2008
18
Nerve resection and re-location may relieve causalgia: a case report. ( 17869421 )
2007
19
Causalgia: an unknown contribution. ( 20503746 )
2006
20
Surgical relief of causalgia with an artificial nerve guide tube: Successful surgical treatment of causalgia (Complex Regional Pain Syndrome Type II) by in situ tissue engineering with a polyglycolic acid-collagen tube. ( 16153773 )
2005
21
Amenorrhea in a patient after treatment with gabapentin for complex regional pain syndrome type II. ( 15100596 )
2004
22
Silas Weir Mitchell, MD: the physician who discovered causalgia. ( 15043886 )
2004
23
Reflex sympathetic dystrophy and causalgia. ( 16106603 )
2004
24
Complex regional pain syndrome: redefining reflex sympathetic dystrophy and causalgia. ( 20086409 )
2004
25
A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II. ( 12855316 )
2003
26
Causalgia: a meta-analysis of the literature. ( 14609871 )
2003
27
Great auricular causalgia: an unusual complication of excision of the submandibular gland. ( 14581027 )
2003
28
The rehabilitation of causalgia (complex regional pain syndrome-type II). ( 11878079 )
2002
29
Thoracoscopic sympathectomy in causalgia. ( 11695793 )
2001
30
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. ( 10870738 )
2000
31
Sympathectomy for causalgia: experience with military injuries. ( 10963537 )
2000
32
Venipuncture-induced causalgia: anatomic relations of upper extremity superficial veins and nerves, and clinical considerations. ( 10988302 )
2000
33
Soleus H-reflex tests in causalgia-dystonia compared with dystonia and mimicked dystonic posture. ( 10599808 )
1999
34
Causalgia, pathological pain, and adrenergic receptors. ( 10393877 )
1999
35
Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? ( 10366221 )
1999
36
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. ( 9841006 )
1998
37
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. ( 9549444 )
1998
38
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Stellate ganglion blockage: clinics take precautions, but few follow guidelines. ( 9841007 )
1998
39
Case report: Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. ( 9516712 )
1998
40
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Terminology is outdated-1994 taxonomy should be used. ( 9732355 )
1998
41
Traumatic neuralgias: complex regional pain syndromes (reflex sympathetic dystrophy and causalgia): clinical characteristics, pathophysiological mechanisms and therapy. ( 9767066 )
1998
42
Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. ( 9107464 )
1997
43
Algodystrophy (reflex sympathetic dystrophy syndrome) and causalgia: novel concepts regarding the nosology, pathophysiology, and pathogenesis of complex regional pain syndromes. Is the sympathetic hyperactivity hypothesis wrong? ( 9338930 )
1997
44
Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. A case report. ( 9055376 )
1997
45
Lumbar sympathectomy for causalgia secondary to lumbar laminectomy. ( 8604835 )
1996
46
Intravenous regional guanethidine in the treatment of reflex sympathetic dystrophy/causalgia: a randomized, double-blind study. Guanethidine Study Group. ( 7574000 )
1995
47
And still capsaicin causes causalgia. ( 7760636 )
1995
48
Capsaicin and the cause of causalgia. ( 7823672 )
1995
49
Peripheral nerve injury and causalgia secondary to routine venipuncture. ( 8190306 )
1994
50
Reflex sympathetic dystrophy/sympathetically maintained pain/causalgia: the syndrome of neuropathic pain with dysautonomia. ( 7701127 )
1994

Variations for Causalgia

Expression for Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for Causalgia

Pathways related to Causalgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 CALCA SCN11A

GO Terms for Causalgia

Cellular components related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.13 CALCA MRAS ZNF135
2 axon GO:0030424 8.62 CALCA SCN11A

Sources for Causalgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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