MCID: CSL001
MIFTS: 45

Causalgia

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Causalgia

MalaCards integrated aliases for Causalgia:

Name: Causalgia 12 74 53 58 54 43 15 17 71 32
Complex Regional Pain Syndrome, Type Ii 12
Complex Regional Pain Syndrome Type 2 58

Characteristics:

Orphanet epidemiological data:

58
complex regional pain syndrome type 2
Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3222
MeSH 43 D002422
NCIt 49 C121572
SNOMED-CT 67 408751001
ICD10 32 G56.4
ICD10 via Orphanet 33 G56.4
UMLS via Orphanet 72 C0007462
Orphanet 58 ORPHA99994
UMLS 71 C0007462

Summaries for Causalgia

NINDS : 53 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Causalgia, also known as complex regional pain syndrome, type ii, is related to complex regional pain syndrome and algoneurodystrophy, and has symptoms including sciatica and neuralgia. An important gene associated with Causalgia is TACR1 (Tachykinin Receptor 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and NFAT and Cardiac Hypertrophy. The drugs Etoricoxib and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and spinal cord, and related phenotypes are Decreased substrate adherent cell growth and cardiovascular system

Wikipedia : 74 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), describes an... more...

Related Diseases for Causalgia

Diseases related to Causalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 complex regional pain syndrome 32.1 TACR1 TAC1 CALCA ADRA1A
2 algoneurodystrophy 31.1 TAC1 NPS CALCA
3 mononeuropathy 29.7 TRPV1 TAC1
4 peripheral nervous system disease 29.2 TRPV1 TAC1 NPS CALCA
5 paine syndrome 28.9 TRPV1 TACR1 TAC1 NPS CALCA
6 reflex sympathetic dystrophy 28.9 TAC1 NPS FAM53B CALCA ADRA2C ADRA2B
7 horner's syndrome 10.4
8 neuroma 10.4
9 autonomic dysfunction 10.3
10 neurotrophic keratopathy 10.3 TACR1 TAC1
11 keratopathy 10.3 TACR1 TAC1
12 retinitis pigmentosa 67 10.2 TACR1 TAC1
13 neurodermatitis 10.2 TAC1 NPS
14 dystonia 10.1
15 erythromelalgia 10.1
16 48,xyyy 10.1
17 raynaud phenomenon 10.1
18 chronic pain 10.1
19 paresthesia 10.1
20 tremor 10.1
21 aids phobia 10.1 TAC1 NPS
22 arachnoiditis 10.1 TAC1 PPP3R2
23 motion sickness 10.1 TACR1 TAC1
24 carbamazepine allergy 10.0 TAC1 NPS CALCA
25 perianal hematoma 10.0 TAC1 NPS CALCA
26 spondylosis, cervical 10.0
27 leprosy 3 10.0
28 cyanosis, transient neonatal 10.0
29 angina pectoris 10.0
30 meningococcal meningitis 10.0
31 allergic hypersensitivity disease 10.0
32 diarrhea 10.0
33 pneumothorax 10.0
34 impotence 10.0
35 exostosis 10.0
36 spondylosis 10.0
37 acromegaly 10.0
38 thoracic outlet syndrome 10.0
39 myelitis 10.0
40 biliary dyskinesia 10.0
41 radiculopathy 10.0
42 movement disease 10.0
43 brachial plexus lesion 10.0
44 neuropathy 10.0
45 neuromyelitis optica 10.0
46 exophthalmos 10.0
47 meningitis 10.0
48 hansen's disease 10.0
49 pure autonomic failure 10.0
50 transverse myelitis 10.0

Graphical network of the top 20 diseases related to Causalgia:



Diseases related to Causalgia

Symptoms & Phenotypes for Causalgia

UMLS symptoms related to Causalgia:


sciatica, neuralgia

GenomeRNAi Phenotypes related to Causalgia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.8 ADRA1A ADRA1B ADRA2B

MGI Mouse Phenotypes related to Causalgia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 ADRA1A ADRA1B ADRA2B ADRA2C TAC1 TACR1

Drugs & Therapeutics for Causalgia

Drugs for Causalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 2 202409-33-4 123619
2 Analgesics Phase 2
3 Immunologic Factors Phase 2
4 Adjuvants, Immunologic Phase 2
5 Neurotropin Phase 2
6 Anticonvulsants Phase 2
7 Cyclooxygenase 2 Inhibitors Phase 2
8 Analgesics, Non-Narcotic Phase 2
9 Cyclooxygenase Inhibitors Phase 2
10 Anti-Inflammatory Agents Phase 2
11 Antirheumatic Agents Phase 2
12 Anti-Inflammatory Agents, Non-Steroidal Phase 2
13
Lidocaine Approved, Vet_approved Early Phase 1 137-58-6 3676
14
parecoxib Approved 198470-84-7
15 Anti-Anxiety Agents
16 Anesthetics Early Phase 1
17 Sodium Channel Blockers Early Phase 1
18 Anti-Arrhythmia Agents Early Phase 1
19 Diuretics, Potassium Sparing Early Phase 1
20 Anesthetics, Local Early Phase 1
21 abobotulinumtoxinA Early Phase 1
22 Botulinum Toxins Early Phase 1
23 Botulinum Toxins, Type A Early Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Restore Claims Characterization Study Completed NCT00200122 Phase 4
2 Surgical Treatment of Complex Regional Pain Syndrome Type II (CRPS II) by Regional Subcutaneous Venous Sympathectomy Unknown status NCT01392599 Phase 3
3 Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia Enrolling by invitation NCT02987855 Phase 1, Phase 2
4 Neurotropin for Acute Dental Pain and for Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
5 Efficacy of Etoricoxib in Patients With Neuropathic Pain With and Without Peripheral Hyperalgesia - A Prove of Concept Trial Terminated NCT01088256 Phase 2 Etoricoxib;placebo
6 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
7 Regional Anesthesia in Combat Trauma Improves Pain Disability Outcomes Completed NCT00431847
8 A Prospective, Randomized, Multi-Center, Controlled Clinical Trial to Assess the Safety and Efficacy of the Spinal Modulation™ AXIUM™ Neurostimulator System in the Treatment of Chronic Pain (ACCURATE Trial) Completed NCT01923285
9 Evoked (Magnetic) Cortical Fields for the Comparative Study of Mechanisms Underlying Chronic Non-malignant Pain in Peripheral Nerve Injury (CRPS II) and CRPS I (Chronic Regional Pain Syndrome I) Completed NCT00217243
10 The Efficacy of Motor Cortex Stimulation for Pain Control Completed NCT00462566
11 Trialing of Intra-spinal Stimulation in Patients With Complex Regional Pain Syndrome or Causalgia Recruiting NCT03954080
12 An Observational Cohort Study to Assess the Long Term Effectiveness of Dorsal Root Ganglion Stimulation for Chronic Pain in the Upper Limb(s) Recruiting NCT02553876
13 Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy in the Complex Regional Pain Syndrome of the Upper Limb : a Multicentric Randomized Open Study. Recruiting NCT02667717
14 Single Center, Randomized Prospective Comparative Effectiveness Study of Dorsal Column Spinal Cord Stimulation to Dorsal Root Ganglion Stimulation in the Treatment of Complex Regional Pain Syndrome Recruiting NCT03794024
15 "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome" Recruiting NCT03616262 Early Phase 1 Botox + Lidocaine;Lidocaine alone
16 Use Of Autologous Stem Cell Use In Neurological Non-neoplastic Disorders And Disease Not yet recruiting NCT03297177
17 Efficiacy of the Selctive COX-2-inhibitor Parecoxibe on the Pathological Low Pressure Pain Threshold (PPT) of Patients With Complex Regional Pain Syndrome (CRPS) No longer available NCT01523379 Parecoxib;Placebo
18 Complex Regional Pain Syndrome Proteomics Study Terminated NCT00033969
19 The Effect of Transcranial Direct Current Stimulation (t-DCS) On the P300 Component of Event-Related Potentials in Patients With Chronic Neuropathic Pain Due To Complex Regional Pain Syndrome (CRPS) or Diabetic Neuropathy-A PILOT, DOUBLE-BLIND, SHAM-CONTROLLED, CROSS-OVER STUDY Withdrawn NCT00815932

Search NIH Clinical Center for Causalgia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Tolazoline
Tolazoline Hydrochloride

Cochrane evidence based reviews: causalgia

Genetic Tests for Causalgia

Anatomical Context for Causalgia

MalaCards organs/tissues related to Causalgia:

40
Skin, Bone, Spinal Cord, Dorsal Root Ganglion, Cortex, Brain, Testes

Publications for Causalgia

Articles related to Causalgia:

(show top 50) (show all 558)
# Title Authors PMID Year
1
A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II. 61 54
12855316 2003
2
Effectiveness and Safety of Dorsal Root Ganglion Stimulation for the Treatment of Chronic Pain: A Pooled Analysis. 61
31730273 2020
3
A case report of wireless peripheral nerve stimulation for complex regional pain syndrome type-I of the upper extremity: 1 year follow up. 61
31442205 2019
4
Neuromodulation of the Dorsal Root Ganglion for Chronic Postsurgical Pain. 61
31152174 2019
5
A mysterious case of complex regional pain syndrome in a 9-year-old girl. 61
29216768 2019
6
Silas Weir Mitchell, MD, LLD, FRC: Neurological Evaluation and Rehabilitation of the Injured Upper Extremity. 61
31014111 2019
7
Complex regional pain syndrome - False hopes and miscommunications. 61
30639650 2019
8
The Role of the Peripheral Nerve Surgeon in the Treatment of Pain. 61
30542905 2019
9
Complex regional pain syndrome type II arising from a gunshot wound (GSW) associated with infective endocarditis and aortic valve replacement. 61
30333197 2018
10
The modified transforaminal endoscopic technique in treating intracanalicular combining foraminal and/or extraforaminal lumbar disc herniations. 61
30505722 2018
11
Wireless peripheral nerve stimulation for complex regional pain syndrome type I of the upper extremity: a case illustration introducing a novel technology. 61
29794269 2018
12
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. 61
29316194 2018
13
Complex regional pain syndrome type II after cervical transforaminal epidural injection: A case report. 61
29768371 2018
14
Efficacy and Safety of Lidocaine Infusion Treatment for Neuropathic Pain: A Randomized, Double-Blind, and Placebo-Controlled Study. 61
29381569 2018
15
Motor-Evoked Potential Analysis of Femoral Nerve Status During the Direct Anterior Approach for Total Hip Arthroplasty. 61
29613926 2018
16
The Efficacy and Safety of Dorsal Root Ganglion Stimulation as a Treatment for Neuropathic Pain: A Literature Review. 61
28960653 2018
17
The Use of Ultrasonography to Identify the Intersection of the Dorsomedial Cutaneous Nerve of the Hallux and the Extensor Hallucis Longus Tendon: A Cadaveric Study. 61
29331290 2018
18
Jules Tinel (1879-1952): Beyond the eponym, the man and his forgotten neurological contributions. 61
28377088 2017
19
Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial. 61
28030470 2017
20
Infraorbital Nerve Decompression for Infraorbital Neuralgia/Causalgia following Blowout Orbital Fractures: A Case Series. 61
28210404 2017
21
Effect of Botulinum Toxin on Disabling Neuropathic Pain: A Case Presentation Suggesting a New Therapeutic Strategy. 61
27810581 2017
22
Ultrasonography-guided pulsed radiofrequency of sciatic nerve for the treatment of complex regional pain syndrome Type II. 61
28217060 2017
23
[Spinal cord stimulation in 62 patients: Retrospective evaluation]. 61
28467566 2017
24
LETM presented with causalgia and ensued by sudden death. 61
28109254 2017
25
Reduction in mechanical allodynia in complex regional pain syndrome patients with ultrasound-guided pulsed radiofrequency treatment of the superficial peroneal nerve. 61
27738506 2016
26
Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection. 61
27651875 2016
27
Systemic Intravenous Lidocaine for the Treatment of Complex Regional Pain Syndrome: A Case Report and Literature Review. 61
26398854 2016
28
Severe Pain and Edema due to a Widespread Lymphangioma: Disappearance of Symptoms and Reduction of Lesion with Spinal Cord Stimulation. 61
27402439 2016
29
Silas Weir Mitchell and "The Strange Case of George Dedlow". 61
27364258 2016
30
Steroid atrophy scarring treated with fat grafting in a patient with complex regional pain syndrome: A case report. 61
26735938 2016
31
Pain Relief in CRPS-II after Spinal Cord and Motor Cortex Simultaneous Dual Stimulation. 61
27228530 2016
32
Neuralgias of the Head: Occipital Neuralgia. 61
27051229 2016
33
[Spinal cord stimulation in the treatment of chronic pain syndromes]. 61
27070257 2016
34
[The Berlin diagnostic algorithm for painful knee TKA]. 61
26679494 2016
35
Silas Weir Mitchell: Neurologists and Neurology during the American Civil War. 61
27035676 2016
36
A Novel Mini-invasive Approach to the Treatment of Neuropathic Pain: The PENS Study. 61
26752480 2016
37
Case study: Gluteal compartment syndrome as a cause of lumbosacral radiculoplexopathy and complex regional pain syndrome. 61
27533628 2016
38
Publications on Peripheral Nerve Injuries during World War I: A Dramatic Increase in Knowledge. 61
27035152 2016
39
Stellate ganglion pulsed radiofrequency ablation for stretch induced complex regional pain syndrome type II. 61
26543471 2015
40
[COMPLEX REGIONAL PAIN SYNDROME]. 61
26749953 2015
41
Surgical animal models of neuropathic pain: Pros and Cons. 61
24831263 2015
42
From Mitchell's causalgia to complex regional pain syndromes: 150 years of definitions and theories. 61
25786040 2015
43
Complex regional pain syndrome (CRPS) type I: historical perspective and critical issues. 61
27134625 2015
44
The complex regional pain syndrome. 61
26563805 2015
45
Complex Regional Pain Syndrome Type II Secondary to Endovascular Aneurysm Repair. 61
25650247 2015
46
How was the Turin Shroud Man crucified? 61
25457335 2014
47
Cervical spinal cord stimulation treatment of deafferentation pain from brachial plexus avulsion injury complicated by complex regional pain syndrome. 61
25611136 2014
48
Nerve resection, crush and re-location relieve complex regional pain syndrome type II: a case report. 61
24502845 2014
49
Upregulation of α1-adrenoceptors on cutaneous nerve fibres after partial sciatic nerve ligation and in complex regional pain syndrome type II. 61
24342464 2014
50
Free flap transfer for complex regional pain syndrome type II. 61
27252946 2014

Variations for Causalgia

Expression for Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for Causalgia

Pathways related to Causalgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 TRPV1 TACR1 TAC1 NPS CALCA ADRA2C
2
Show member pathways
12.5 PPP3R2 ADRA2B ADRA1B ADRA1A
3
Show member pathways
12.19 PPP3R2 CALCA ADRA1B ADRA1A
4
Show member pathways
12.15 PPP3R2 ADRA2C ADRA2B ADRA1B ADRA1A
5
Show member pathways
11.97 TACR1 PPP3R2 ADRA1B ADRA1A
6
Show member pathways
11.86 ADRA2C ADRA2B ADRA1B ADRA1A
7
Show member pathways
11.5 ADRA2C ADRA2B ADRA1B ADRA1A
8 11.01 CALCA ADRA1A
9 10.29 ADRA2C ADRA2B ADRA1B ADRA1A
10 10.25 TACR1 TAC1

GO Terms for Causalgia

Cellular components related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.46 TRPV1 TAC1 CALCA ADRA2C
2 integral component of plasma membrane GO:0005887 9.43 TRPV1 TACR1 ADRA2C ADRA2B ADRA1B ADRA1A
3 cell GO:0005623 9.1 TRPV1 TACR1 TAC1 CALCA ADRA1B ADRA1A

Biological processes related to Causalgia according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.03 TACR1 TAC1 NPS CALCA ADRA2C ADRA2B
2 inflammatory response GO:0006954 9.92 TRPV1 TACR1 TAC1 CALCA
3 cell-cell signaling GO:0007267 9.85 TAC1 CALCA ADRA2C ADRA2B ADRA1B ADRA1A
4 positive regulation of MAPK cascade GO:0043410 9.8 ADRA2C ADRA2B ADRA1B ADRA1A
5 neuropeptide signaling pathway GO:0007218 9.79 TAC1 NPS CALCA
6 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.78 ADRA2C ADRA2B ADRA1B ADRA1A
7 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.76 TACR1 ADRA1B ADRA1A
8 cellular response to nerve growth factor stimulus GO:1990090 9.7 TRPV1 TAC1 CALCA
9 positive regulation of vasoconstriction GO:0045907 9.69 ADRA2C ADRA1B ADRA1A
10 response to heat GO:0009408 9.65 TRPV1 CALCA
11 activation of protein kinase B activity GO:0032148 9.65 ADRA2C ADRA2B
12 regulation of cardiac muscle contraction GO:0055117 9.64 ADRA1B ADRA1A
13 positive regulation of smooth muscle contraction GO:0045987 9.64 ADRA1B ADRA1A
14 regulation of smooth muscle contraction GO:0006940 9.63 ADRA2C ADRA2B
15 regulation of muscle contraction GO:0006937 9.63 ADRA1B ADRA1A
16 positive regulation of synaptic transmission, GABAergic GO:0032230 9.63 TAC1 NPS ADRA1A
17 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.62 TRPV1 CALCA
18 regulation of vasoconstriction GO:0019229 9.62 ADRA2C ADRA2B ADRA1B ADRA1A
19 negative regulation of heart rate GO:0010459 9.61 TRPV1 TAC1
20 negative regulation of norepinephrine secretion GO:0010700 9.6 ADRA2C ADRA2B
21 tachykinin receptor signaling pathway GO:0007217 9.59 TACR1 TAC1
22 receptor transactivation GO:0035624 9.58 ADRA2C ADRA2B
23 positive regulation of action potential GO:0045760 9.58 TAC1 NPS ADRA1A
24 negative regulation of epinephrine secretion GO:0032811 9.57 ADRA2C ADRA2B
25 detection of abiotic stimulus GO:0009582 9.56 TACR1 TAC1
26 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.56 ADRA2C ADRA2B ADRA1B ADRA1A
27 positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 9.55 ADRA1B ADRA1A
28 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.54 ADRA1B ADRA1A
29 response to pain GO:0048265 9.46 TRPV1 TACR1 TAC1 CALCA
30 positive regulation of cytosolic calcium ion concentration GO:0007204 9.43 TRPV1 TACR1 TAC1 CALCA ADRA1B ADRA1A
31 adrenergic receptor signaling pathway GO:0071875 8.92 ADRA2C ADRA2B ADRA1B ADRA1A

Molecular functions related to Causalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.72 TACR1 ADRA2C ADRA2B ADRA1B ADRA1A
2 epinephrine binding GO:0051379 9.26 ADRA2C ADRA2B
3 alpha2-adrenergic receptor activity GO:0004938 9.16 ADRA2C ADRA2B
4 alpha1-adrenergic receptor activity GO:0004937 8.96 ADRA1B ADRA1A
5 adrenergic receptor activity GO:0004935 8.92 ADRA2C ADRA2B ADRA1B ADRA1A

Sources for Causalgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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