MCID: CVR001
MIFTS: 25

Cavernous Sinus Meningioma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Cavernous Sinus Meningioma

MalaCards integrated aliases for Cavernous Sinus Meningioma:

Name: Cavernous Sinus Meningioma 12 6 15 70
Meningioma of the Cavernous Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4435
NCIt 50 C5268
UMLS 70 C1332865

Summaries for Cavernous Sinus Meningioma

MalaCards based summary : Cavernous Sinus Meningioma, also known as meningioma of the cavernous sinus, is related to meningioma, familial and intracranial meningioma, and has symptoms including seizures and headache. An important gene associated with Cavernous Sinus Meningioma is KMT2D (Lysine Methyltransferase 2D), and among its related pathways/superpathways is Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Cavernous Sinus Meningioma

Diseases related to Cavernous Sinus Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 10.8
2 intracranial meningioma 10.8
3 secretory meningioma 10.8
4 lymphoplasmacyte-rich meningioma 10.8
5 ptosis 10.4
6 kearns-sayre syndrome 10.2
7 carotid artery occlusion 10.2
8 exophthalmos 10.2
9 aphasia 10.2
10 cranial nerve palsy 10.2
11 headache 10.2
12 psammomatous meningioma 10.1
13 glioma susceptibility 1 10.0
14 strabismus 10.0
15 myeloma, multiple 10.0
16 thrombosis 10.0
17 arteriovenous malformation 10.0
18 alternating exotropia 10.0
19 exotropia 10.0
20 carotid stenosis 10.0
21 facial neuralgia 10.0
22 optic nerve disease 10.0
23 hemangioma 10.0
24 malignant astrocytoma 10.0
25 anaplastic astrocytoma 10.0
26 neurilemmoma 10.0
27 plasmacytoma 10.0
28 skull base meningioma 10.0
29 pituitary gland disease 10.0
30 fibrous meningioma 10.0
31 childhood leukemia 10.0
32 sphenoorbital meningioma 10.0
33 mechanical strabismus 10.0
34 cluster headache 10.0
35 ocular neuromyotonia 10.0
36 cavernous malformation 10.0
37 posttransplant acute limbic encephalitis 10.0
38 specific language disorder 10.0
39 cranial neuralgia 10.0
40 familial adenomatous polyposis 4 9.9 MSH3 DHFR
41 megaloblastic anemia due to dihydrofolate reductase deficiency 9.9 MSH3 DHFR
42 megaloblastic anemia 9.9 MSH3 DHFR
43 langerhans cell sarcoma 9.7 CD207 CD163
44 histiocytic and dendritic cell cancer 9.7 CD207 CD163
45 non-langerhans-cell histiocytosis 9.7 CD207 CD163
46 histiocytosis 9.7 CD207 CD163
47 adult xanthogranuloma 9.6 CD207 CD163
48 langerhans cell histiocytosis 9.6 CD207 CD163
49 fanconi anemia, complementation group a 9.3 MSH3 KMT2D DHFR

Graphical network of the top 20 diseases related to Cavernous Sinus Meningioma:



Diseases related to Cavernous Sinus Meningioma

Symptoms & Phenotypes for Cavernous Sinus Meningioma

UMLS symptoms related to Cavernous Sinus Meningioma:


seizures; headache

GenomeRNAi Phenotypes related to Cavernous Sinus Meningioma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 9.77 CD163
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.77 CD163 DHFR
3 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.77 CD163
4 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.77 CD163
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.77 CD163
6 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.77 CD207 DHFR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 CD163
8 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.77 CD207
9 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.77 DHFR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.77 DHFR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.77 CD207
12 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.77 CD207
13 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.77 CD163
14 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.77 CD163
15 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 CD207
16 Increased shRNA abundance (Z-score > 2) GR00366-A-86 9.77 DHFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.77 CD163

Drugs & Therapeutics for Cavernous Sinus Meningioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Irradiation of the Cavernous Sinus and the Sellar Region on Autobiographical Memory Active, not recruiting NCT02750371

Search NIH Clinical Center for Cavernous Sinus Meningioma

Genetic Tests for Cavernous Sinus Meningioma

Anatomical Context for Cavernous Sinus Meningioma

MalaCards organs/tissues related to Cavernous Sinus Meningioma:

40
Pituitary

Publications for Cavernous Sinus Meningioma

Articles related to Cavernous Sinus Meningioma:

(show top 50) (show all 93)
# Title Authors PMID Year
1
Postpartum Recovery From Meningioma-Related Oculomotor Palsy. 61
33706360 2021
2
Cavernous Sinus Meningioma Resection Through Orbitozygomatic Craniotomy. 61
33515796 2021
3
Intracranial Plasmacytoma Mimicking a Cavernous Sinus Meningioma. 61
33614321 2021
4
Radiation-induced cavernous malformation after stereotactic radiosurgery for cavernous sinus meningioma: a case report. 61
33218314 2020
5
Intracranial soft-tissue glomus tumor (glomangioma) in a young-woman. A case report and review of the literature. 61
33295301 2020
6
Phantosmia as the first presentation of a cavernous sinus - clinoidal meningioma. 61
33050720 2020
7
Resection of Invasive Sphenoorbital and Cavernous Sinus Meningioma via Frontotemporal Craniotomy. 61
32416238 2020
8
Cavernous Sinus Meningioma with Orbital Involvement: Algorithmic Decision-Making and Treatment Strategy. 61
33072476 2020
9
Commentary: Resection of Cavernous Sinus Meningioma via Lateral Orbitotomy Approach: 2-Dimensional Operative Video. 61
31313818 2020
10
Predictors of visual functional outcome following treatment for cavernous sinus meningioma. 61
32413851 2020
11
Resection of Cavernous Sinus Meningioma via Lateral Orbitotomy Approach: 2-Dimensional Operative Video. 61
31301136 2020
12
Cavernous sinus meningioma. 61
32586510 2020
13
Inter-Observer Variability in Target Volume Delineations of Benign and Metastatic Brain Tumours for Stereotactic Radiosurgery: Results of a National Quality Assurance Programme. 61
31301960 2020
14
Risk of internal carotid artery stenosis or occlusion after single-fraction radiosurgery for benign parasellar tumors. 61
31653808 2019
15
Immunological and vascular characteristics in cavernous sinus meningioma. 61
31213381 2019
16
Nonsecretory Paraganglioma in Cavernous Sinus Masquerading as Meningioma. 61
30831293 2019
17
[Progress in the treatment of cavernous sinus meningioma]. 61
30929379 2019
18
Management of Cavernous Sinus Meningioma Presenting With Cerebrovascular Insufficiency Secondary to Cavernous Carotid Artery Occlusion: Report of 2 Cases. 61
29850864 2019
19
Antiphospholipid syndrome and neurofibromatosis type I: a coincidence or new association? 61
30726411 2019
20
Evidence-based treatment of cavernous sinus meningioma. 61
31819821 2019
21
Microsurgical Resection of Cavernous Sinus Meningioma: 2-Dimensional Operative Video. 61
29514273 2018
22
Radiosurgery and fractionated radiotherapy for cavernous sinus meningioma: a systematic review and meta-analysis. 61
30393820 2018
23
Endoscopic Endonasal Transmaxillary Transsphenoidal Approach for Excision of a Superior Orbital Fissure-Cavernous Sinus Meningioma: 2-Dimensional Operative Video. 61
29718332 2018
24
Multi-institutional study of the variability in target delineation for six targets commonly treated with radiosurgery. 61
29786462 2018
25
Cranial nerve outcomes after primary stereotactic radiosurgery for symptomatic skull base meningiomas. 61
29691775 2018
26
Gamma Knife stereotactic radiosurgery for cavernous sinus meningioma: long-term follow-up in 200 patients. 61
30028261 2018
27
Cavernous sinus meningioma presenting as third nerve palsy in pregnancy. 61
29754131 2018
28
The Occipital Artery as an Alternative Donor for Low-Flow Bypass to Anterior Circulation After Internal Carotid Artery Occlusion Failure prior to Exenteration for an Atypical Cavernous Sinus Meningioma. 61
28887285 2018
29
Single- and Multi-Fraction Stereotactic Radiosurgery Dose Tolerances of the Optic Pathways. 61
29534899 2018
30
Optic disc drusen: longitudinal aspects, with emphasis on visual field constriction and enlarged blind spot: a retrospective hospital-based clinical series. 61
27646322 2017
31
Gamma Knife Radiosurgery for Cavernous Sinus Meningiomas: Analysis of Outcome in 166 Patients. 61
28797005 2017
32
Assessment of organs-at-risk contouring practices in radiosurgery institutions around the world - The first initiative of the OAR Standardization Working Group. 61
27816408 2016
33
Outcomes after surgical treatment of meningioma-associated proptosis. 61
26799293 2016
34
Postpartum Regression of a Presumed Cavernous Meningioma. 61
27066285 2016
35
Stereotactic Gamma Knife surgery safety and efficacy in the management of symptomatic benign confined cavernous sinus meningioma. 61
26231629 2015
36
[Secondary cluster headache due to cavernous sinus meningioma]. 61
25944140 2015
37
Variability in target delineation for cavernous sinus meningioma and anaplastic astrocytoma in stereotactic radiosurgery with Leksell Gamma Knife Perfexion. 61
25246145 2014
38
Urgent cerebral revascularization bypass surgery for iatrogenic skull base internal carotid artery injury. 61
25181433 2014
39
Uterine Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy). 61
24901405 2014
40
Critical appraisal of RapidArc radiosurgery with flattening filter free photon beams for benign brain lesions in comparison to GammaKnife: a treatment planning study. 61
24884967 2014
41
Successful Management of Refractory Headache and Facial Pain due to Cavernous Sinus Meningioma with Sphenopalatine Ganglion Radiofrequency. 61
25343051 2014
42
Adenoid cystic carcinoma in the cavernous sinus diagnosed with the endoscopic endonasal approach. 61
25269060 2014
43
[Ptosis secondary to cavernous sinus meningioma]. 61
23932584 2013
44
Long-term evaluation of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery. 61
24074926 2013
45
Lateral orbital wall approach to the cavernous sinus. 61
22242672 2012
46
Stereotactic radiosurgery of intracranial tumors: a comparison of intensity-modulated radiosurgery and dynamic conformational arc. 61
29296327 2012
47
Nasopharyngeal carcinoma presented as cavernous sinus tumour. 61
22355975 2011
48
Superior and inferior ophthalmic veins thrombosis with cavernous sinus meningioma. 61
21887086 2011
49
Meningiomas involving the optic canal: pattern of involvement and implications for surgical technique. 61
21529168 2011
50
Fractionated conformal radiotherapy in the management of cavernous sinus meningiomas: long-term functional outcome and tumor control at a single institution. 61
20133076 2010

Variations for Cavernous Sinus Meningioma

ClinVar genetic disease variations for Cavernous Sinus Meningioma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 KMT2D NM_003482.3(KMT2D):c.11047C>T (p.Gln3683Ter) SNV Likely pathogenic 635179 rs1565779530 GRCh37: 12:49427441-49427441
GRCh38: 12:49033658-49033658
2 DHFR , MSH3 NM_002439.5(MSH3):c.178G>C (p.Ala60Pro) SNV Uncertain significance 635180 rs2001675 GRCh37: 5:79950724-79950724
GRCh38: 5:80654905-80654905

Expression for Cavernous Sinus Meningioma

Search GEO for disease gene expression data for Cavernous Sinus Meningioma.

Pathways for Cavernous Sinus Meningioma

Pathways related to Cavernous Sinus Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 CD207 CD163

GO Terms for Cavernous Sinus Meningioma

Biological processes related to Cavernous Sinus Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 8.62 CD207 CD163

Sources for Cavernous Sinus Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....