MCID: CVR002
MIFTS: 34

Cavernous Sinus Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cavernous Sinus Thrombosis

MalaCards integrated aliases for Cavernous Sinus Thrombosis:

Name: Cavernous Sinus Thrombosis 12 73 44 15 70
Thrombosis of Cavernous Venous Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3575
MeSH 44 D020226
SNOMED-CT 67 89980009
UMLS 70 C0238454

Summaries for Cavernous Sinus Thrombosis

MalaCards based summary : Cavernous Sinus Thrombosis, also known as thrombosis of cavernous venous sinus, is related to thrombosis and mucormycosis. An important gene associated with Cavernous Sinus Thrombosis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drug Metronidazole has been mentioned in the context of this disorder. Affiliated tissues include pituitary, eye and bone marrow, and related phenotypes are cardiovascular system and immune system

Wikipedia : 73 Cavernous sinus thrombosis (CST) is the formation of a blood clot within the cavernous sinus, a cavity... more...

Related Diseases for Cavernous Sinus Thrombosis

Diseases related to Cavernous Sinus Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 368)
# Related Disease Score Top Affiliating Genes
1 thrombosis 31.8 SERPINC1 F3 F2
2 mucormycosis 30.9 INS CRP
3 cranial nerve palsy 30.9 SERPINC1 CRP
4 pleural empyema 30.9 F2 CRP
5 subdural empyema 30.8 F2 CRP
6 lemierre's syndrome 30.8 F3 F2 CRP
7 carotid artery thrombosis 30.8 SERPINC1 F3
8 cellulitis 30.7 INS F3 F2 CRP
9 thrombophlebitis 30.5 SERPINC1 F3 F2 CRP
10 toxic shock syndrome 30.5 SERPINC1 F3 CRP
11 retinal artery occlusion 30.3 SERPINC1 F2 CRP
12 nonarteritic anterior ischemic optic neuropathy 30.3 SERPINC1 F2 CRP
13 central retinal vein occlusion 30.2 SERPINC1 F3 F2
14 retinal vein occlusion 30.2 SERPINC1 F3 F2
15 thrombophilia 30.2 SERPINC1 F3 F2
16 intracranial hypertension 30.2 SERPINC1 F3 F2
17 thrombophilia due to thrombin defect 30.2 SERPINC1 F3 F2
18 abducens nerve disease 30.1 SERPINC1 F2 CRP
19 central retinal artery occlusion 30.1 SERPINC1 F2 CRP
20 epidural abscess 30.1 F3 F2 CRP
21 exanthem 30.0 F3 F2 CRP
22 branch retinal artery occlusion 30.0 SERPINC1 F3 F2 CRP
23 pulmonary embolism 30.0 SERPINC1 F3 F2 CRP
24 leptospirosis 29.9 F2 CRP
25 respiratory failure 29.9 F3 F2 CRP
26 cerebrovascular disease 29.8 INS F2 CRP
27 nephrotic syndrome 29.7 SERPINC1 F3 F2 CRP
28 exophthalmos 10.7
29 kearns-sayre syndrome 10.6
30 orbital cellulitis 10.6
31 yemenite deaf-blind hypopigmentation syndrome 10.6
32 ptosis 10.6
33 sphenoid sinusitis 10.6
34 meningitis 10.6
35 osteomyelitis 10.4
36 hypopituitarism 10.4
37 headache 10.3
38 blue toe syndrome 10.3 SERPINC1 CRP
39 cerebral arteritis 10.3 SERPINC1 CRP
40 aspergillosis 10.3
41 petrositis 10.3
42 facial paralysis 10.3
43 optic nerve disease 10.3
44 subclavian steal syndrome 10.3 F3 CRP
45 heparin-induced thrombocytopenia 10.3 SERPINC1 F3
46 vulvar angiokeratoma 10.3 SERPINC1 F3
47 aspiration pneumonitis 10.3 F3 CRP
48 syphilitic meningitis 10.3 SERPINC1 CRP
49 ludwig's angina 10.3 NCBP3 CRP
50 tinea unguium 10.3 NCBP3 CRP

Graphical network of the top 20 diseases related to Cavernous Sinus Thrombosis:



Diseases related to Cavernous Sinus Thrombosis

Symptoms & Phenotypes for Cavernous Sinus Thrombosis

MGI Mouse Phenotypes related to Cavernous Sinus Thrombosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CNDP2 CRP F2 F3 INS NCBP3
2 immune system MP:0005387 9.17 CNDP2 CRP F2 F3 IL1RL2 INS

Drugs & Therapeutics for Cavernous Sinus Thrombosis

Drugs for Cavernous Sinus Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Feasibility of the Infinity Guide Catheter for Neuro Interventional Procedures Using Transradial Access Recruiting NCT04553549

Search NIH Clinical Center for Cavernous Sinus Thrombosis

Cochrane evidence based reviews: cavernous sinus thrombosis

Genetic Tests for Cavernous Sinus Thrombosis

Anatomical Context for Cavernous Sinus Thrombosis

MalaCards organs/tissues related to Cavernous Sinus Thrombosis:

40
Pituitary, Eye, Bone Marrow, Skin, Thyroid, Myeloid

Publications for Cavernous Sinus Thrombosis

Articles related to Cavernous Sinus Thrombosis:

(show top 50) (show all 610)
# Title Authors PMID Year
1
Infectious Cavernous Sinus Thrombosis Presenting as Temporal Arteritis-A Case Report. 61
33791059 2021
2
Cavernous sinus thrombosis in a COVID-19 patient: A case report. 61
33318774 2021
3
Lemierre's syndrome with cavernous sinus thrombosis caused by dental infection. 61
33727287 2021
4
Cavernous sinus thrombosis: a late complication of head and neck surgery. 61
33541954 2021
5
A covid-19 Patient with Cavernous Sinus Thrombosis Post Dental Extraction a Diagnostic Dilemma. 61
33654682 2021
6
Paediatric periorbital cellulitis: A 10-year retrospective case series review. 61
32987452 2021
7
Cavernous Sinus Thrombosis related to Orbital Cellulitis Serious Complication to Prevent: a case report and literature review. 61
33532066 2021
8
Bilateral cavernous sinus and left dural sigmoid sinus thrombosis associated with extreme exertion: a case report. 61
33470347 2021
9
Skull base osteomyelitis with secondary cavernous sinus thrombosis: a rare presentation of an animate foreign body in the ear. 61
33431445 2021
10
Spontaneous Abscess of the Posterior Nasal Septum: An Unusual Cause of Nasal Obstruction in Children. 61
33423503 2021
11
Risk factors of orbital complications in outpatients presenting with severe rhinosinusitis: A case-control study. 61
33453706 2021
12
A Unique Radiologic Case of Optic Nerve Infarction in a Patient With Mucormycosis. 61
33449489 2021
13
The diagnostic dilemma of a pregnant woman presenting with an isolated sixth nerve palsy: A case report. 61
33343697 2020
14
Bilateral cavernous sinus thrombosis complicating acute unilateral pansinusitis in a 15-year-old boy. 61
33370987 2020
15
Cavernous sinus lesions. 61
32574933 2020
16
Cavernous sinus thrombosis after follow-up cerebral angiography. 61
33283067 2020
17
The role of imaging in skull base osteomyelitis - Reviewed. 61
32526659 2020
18
Subacute Cavernous Sinus Thrombosis following a Dental Procedure: Case Report and Review of the Literature. 61
32836064 2020
19
Septic cavernous sinus thrombosis-Case series and review of the literature. 61
32693341 2020
20
Diagnostic difficulties in a patient with multiple sclerosis who presents with cranial nerve palsies: an unusual complication of dental work. 61
33127721 2020
21
[Neurotrophic keratitis secondary to cavernous sinus thrombosis]. 61
32622632 2020
22
SEPTIC CAVERNOUS SINUS THROMBOSIS; A RARE CAUSE OF UNILATERAL EXOPHTHALMOS. 61
33093709 2020
23
Our experience in the management of orbital complications in acute rhinosinusitis. 61
32389323 2020
24
A Challenging Case of Lemierre's Syndrome With Central Nervous System Involvement and a Comprehensive Review. 61
32879837 2020
25
Allergic fungal sinusitis masquerading as cavernous sinus thrombosis. 61
32855797 2020
26
Bilateral cellulitis caused by invasive aspergillosis associated with bilateral intraorbital abscesses: a case report. 61
32799822 2020
27
Orbital Apex Syndrome: A Clinico-anatomical Diagnosis. 61
33531965 2020
28
Cavernous sinus thrombosis caused by Streptococcus constellatus-associated Lemierre syndrome presenting as an isolated abducens nerve palsy. 61
32123771 2020
29
Septic Bilateral Cavernous Sinus Thrombosis With Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia. 61
32670691 2020
30
Imaging of cerebral venous thrombosis. 61
31980184 2020
31
Herpes zoster in the ophthalmic branch of the trigeminal ganglia obscuring cavernous sinus thrombosis due to Streptococcus constellatus subsp. constellatus - A case report. 61
33329815 2020
32
Neurovascular Behçet's Disease Presenting with Cavernous Sinus Thrombosis: A Rare Case of Assumed Tolosa-Hunt-Like Syndrome. 61
32637928 2020
33
Smoldering multiple myeloma revealed by superior ophthalmic vein thrombosis. 61
33542992 2020
34
Panophthalmitis and Orbital Inflammation with Cavernous Sinus Thrombosis Following Cataract Surgery. 61
33173353 2020
35
Gradenigo's Syndrome with Carotid Septic Stenosis. 61
32148988 2020
36
MR imaging of cavernous sinus thrombosis. 61
32154332 2020
37
Carotid-cavernous fistula from the perspective of an ophthalmologist A Review. 61
33086846 2020
38
[Orbital cellulitis in children: Report of 60 cases]. 61
31722808 2019
39
Effectiveness of endoscopic versus external surgical approaches in the treatment of orbital complications of rhinosinusitis: a systematic review protocol. 61
31313706 2019
40
When the Problem Became the Solution. 61
31270004 2019
41
Septic cavernous sinus thrombosis in a paediatric patient with undiagnosed thrombophilia. 61
31666249 2019
42
Cavernous Sinus Thrombosis Secondary to Sphenoid Sinus Fungal Ball. 61
31291783 2019
43
The clinical characteristics, implicated pathogens and therapeutic outcomes of culture-proven septic cavernous sinus thrombosis. 61
31331748 2019
44
Severe Intraoperative Orbital Venous Congestion during Resection of a Frontal Meningioma Presenting with Post-operative Vision Loss and Ophthalmoplegia: A Case Report. 61
31528194 2019
45
Non-Traumatic Pneumocephalus and Sub-Dural Empyema as a Complication of Chronic Sinusitis. 61
31565608 2019
46
Mediastinitis as complication of odontogenic infection: A case report. 61
31187775 2019
47
Orbital Complications of Rhinosinusitis in the Adult Population: Analysis of Cases Presenting to a Tertiary Medical Center Over a 13-Year Period. 61
30788974 2019
48
Impact of superior ophthalmic vein thrombosis: a case series and literature review. 61
30040506 2019
49
Lateral rectus atrophy in cavernous sinus thrombosis. 61
30341446 2019
50
Septic cavernous sinus thrombosis: potentially fatal conjunctival hyperemia. 61
30062575 2019

Variations for Cavernous Sinus Thrombosis

Expression for Cavernous Sinus Thrombosis

Search GEO for disease gene expression data for Cavernous Sinus Thrombosis.

Pathways for Cavernous Sinus Thrombosis

Pathways related to Cavernous Sinus Thrombosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.66 INS F2 CRP
2
Show member pathways
11.33 SERPINC1 F3 F2
3 10.96 SERPINC1 F3 F2
4 10.9 INS F2

GO Terms for Cavernous Sinus Thrombosis

Cellular components related to Cavernous Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.92 TSPAN15 SERPINC1 INS F2

Biological processes related to Cavernous Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.5 SERPINC1 F3 F2
2 positive regulation of protein localization to nucleus GO:1900182 9.4 INS F2
3 negative regulation of proteolysis GO:0045861 9.37 INS F2
4 hemostasis GO:0007599 9.33 SERPINC1 F3 F2
5 regulation of blood coagulation GO:0030193 9.26 SERPINC1 F2
6 cellular protein metabolic process GO:0044267 9.26 TSPAN15 SERPINC1 INS F2
7 acute-phase response GO:0006953 8.8 INS F2 CRP

Molecular functions related to Cavernous Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 SERPINC1 INS F3

Sources for Cavernous Sinus Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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