Cd45 Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CD4001 MIFTS: 29	Cd45 Deficiency Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Cd45 Deficiency

MalaCards integrated aliases for Cd45 Deficiency:

Name: Cd45 Deficiency ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060014

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Summaries for Cd45 Deficiency

Disease Ontology : ¹² A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age.

MalaCards based summary : Cd45 Deficiency is related to severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive and autoimmune cardiomyopathy. An important gene associated with Cd45 Deficiency is PTPN6 (Protein Tyrosine Phosphatase Non-Receptor Type 6), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include t cells, nk cells and myeloid, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Cd45 Deficiency

Diseases related to Cd45 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive	11.5
2	autoimmune cardiomyopathy	9.9	LCK FYN
3	alzheimer disease	9.9
4	thymus gland disease	9.7	PTPRC LCK
5	common variable immunodeficiency	9.3	ZAP70 VAV1 LCK
6	wiskott-aldrich syndrome	9.3	ZAP70 VAV1 FYN
7	severe combined immunodeficiency	9.2	ZAP70 PTPRC LCK FYN
8	leukemia, chronic myeloid	9.2	PTPRC PTPN6 LYN LCK
9	leukemia, chronic lymphocytic	8.9	ZAP70 PTPRC LYN LCK
10	leukemia, acute myeloid	8.8	VAV1 PTPRC LYN LCK

Graphical network of the top 20 diseases related to Cd45 Deficiency:

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Symptoms & Phenotypes for Cd45 Deficiency

GenomeRNAi Phenotypes related to Cd45 Deficiency according to GeneCards Suite gene sharing:

²⁶ (show all 16)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00107-A-1	10.85	ZAP70
2	Decreased viability	GR00221-A-1	10.85	LCK ZAP70 FYN CSK
3	Decreased viability	GR00221-A-2	10.85	LCK ZAP70 FYN VAV1
4	Decreased viability	GR00221-A-3	10.85	LCK LYN VAV1 CSK
5	Decreased viability	GR00221-A-4	10.85	VAV1
6	Decreased viability	GR00240-S-1	10.85	FYN
7	Decreased viability	GR00301-A	10.85	LCK
8	Decreased viability	GR00342-S-1	10.85	LCK LYN ZAP70
9	Decreased viability	GR00342-S-2	10.85	LYN ZAP70
10	Decreased viability	GR00342-S-3	10.85	LCK LYN
11	Decreased viability	GR00402-S-2	10.85	LCK LYN ZAP70 FYN VAV1 CSK
12	Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance	GR00210-A	9.72	CSK FYN LYN PTPN6 PTPRC
13	Decreased cell migration	GR00055-A-1	9.67	LCK LYN PTPN6 ZAP70
14	Increased cell migration	GR00055-A-3	9.33	LCK LYN PTPN6
15	shRNA abundance <= 50%	GR00343-S	9.17	ACP1 CSK FYN LCK PTPRC PTPRJ
16	Increased cell viability after pRB stimulation	GR00230-A-1	9.13	CSK LCK ZAP70

MGI Mouse Phenotypes related to Cd45 Deficiency:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.87	ACP1 CSK FYN PTPN6 PTPRC VAV1
2	hematopoietic system	MP:0005397	9.81	CSK FYN LCK LYN PTPN6 PTPRC
3	endocrine/exocrine gland	MP:0005379	9.8	CSK FYN LCK PTPN6 PTPRC VAV1
4	immune system	MP:0005387	9.65	ACP1 CSK FYN LCK LYN PTPN6
5	respiratory system	MP:0005388	9.1	CSK LYN PTPN6 PTPRC PTPRJ ZAP70

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Drugs & Therapeutics for Cd45 Deficiency

Search Clinical Trials , NIH Clinical Center for Cd45 Deficiency

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Genetic Tests for Cd45 Deficiency

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Anatomical Context for Cd45 Deficiency

MalaCards organs/tissues related to Cd45 Deficiency:

⁴⁰

T Cells, Nk Cells, Myeloid, Thymus, B Cells

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Publications for Cd45 Deficiency

Articles related to Cd45 Deficiency:

(show all 13)

#	Title	Authors	PMID	Year
1	CD45 in human physiology and clinical medicine. ⁶¹	Rheinlander A...Bommhardt U	29366662	2018
2	GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis. ⁶¹	Novak J...Fajka-Boja R	24231767	2014
3	Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. ⁶¹	Stepanek O...Brdicka T	21543337	2011
4	Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. ⁶¹	Hesslein DG...Lanier LL	21245479	2011
5	CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. ⁶¹	Zhu Y...Tan J	21273420	2011
6	CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes. ⁶¹	Lai JC...Johnson P	20624943	2010
7	CD45 regulates thymocyte survival during development in fetal thymic organ culture. ⁶¹	Ferguson BV...Ostergaard HL	19765855	2010
8	Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest. ⁶¹	Moore GT...d'Apice AJ	18155296	2008
9	Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. ⁶¹	Kung C...Thomas ML	10700239	2000
10	Surface expression of hemopoietic cell phosphatase fails to complement CD45 deficiency and inhibits TCR-mediated signal transduction in a Jurkat T cell clone. ⁶¹	Musci MA...Koretzky GA	9029091	1997
11	Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone. ⁶¹	Motto DG...Koretzky GA	7931069	1994
12	Activation of CD45-deficient T cell clones by lectin mitogens but not anti-Thy-1. ⁶¹	Pingel JT...Thomas ML	7908828	1994
13	CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli. ⁶¹	Weaver CT...Thomas ML	1652055	1991

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Genes for Cd45 Deficiency

Genes related to Cd45 Deficiency (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	10.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	6.81	DISEASES inferred ¹⁵
3	ACP1	Acid Phosphatase 1	Protein Coding	6.48	GeneCards inferred via : Publications (show sections)
4	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6.44	DISEASES inferred ¹⁵
5	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	6.43	DISEASES inferred ¹⁵
6	CSK	C-Terminal Src Kinase	Protein Coding	6.06	DISEASES inferred ¹⁵
7	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	5.65	DISEASES inferred ¹⁵
8	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	5.6	DISEASES inferred ¹⁵
9	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	5.47	DISEASES inferred ¹⁵
10	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	5.18	DISEASES inferred ¹⁵

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Variations for Cd45 Deficiency

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Expression for Cd45 Deficiency

Search GEO for disease gene expression data for Cd45 Deficiency.

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Pathways for Cd45 Deficiency

Pathways related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 67)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.92	ZAP70 VAV1 PTPRJ PTPRC PTPN6 LYN
2	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.31	ZAP70 VAV1 PTPRJ PTPRC PTPN6 LYN
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.28	VAV1 PTPN6 LYN LCK FYN CSK
4	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	13.24	VAV1 PTPN6 LYN LCK FYN CSK
5	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.11	VAV1 PTPRC LYN LCK FYN
6	GAB1 signalosome ⁶⁵ Show member pathways Constitutive Signaling by Aberrant PI3K in Cancer ⁶⁵ Negative regulation of the PI3K/AKT network ⁶⁵ PI3K/AKT activation ⁶⁵ PI3K/AKT Signaling in Cancer ⁶⁵ PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ⁶⁵ PIP3 activates AKT signaling ⁶⁵ Role of LAT2/NTAL/LAB on calcium mobilization ⁶⁵	13.04	VAV1 LYN LCK FYN CSK
7	TCR Signaling (Qiagen) ⁶³ Show member pathways Fc-EpsilonRI Pathway ⁶³ ITK and TCR Signaling ⁶³ PKC-Theta Pathway ⁶³ TCR Signaling ⁶³	12.85	ZAP70 VAV1 PTPRC LYN LCK FYN
8	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.77	ZAP70 VAV1 LYN FYN
9	MAPK-Erk Pathway ⁶⁶ Show member pathways Actin Dynamics Signaling Pathway ⁶⁶ G Protein-coupled Receptors Signaling ⁶⁶	12.75	VAV1 LYN LCK FYN
10	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.7	VAV1 PTPN6 LYN LCK FYN
11	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.64	ZAP70 VAV1 LYN FYN
12	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.62	ZAP70 VAV1 PTPRC LYN LCK FYN
13	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁶	12.57	VAV1 PTPRC PTPN6 LYN FYN
14	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.56	ZAP70 VAV1 PTPRC PTPN6 LCK FYN
15	NF-kappaB Signaling ⁴	12.55	ZAP70 PTPRC PTPN6 LYN LCK
16	Development Dopamine D2 receptor transactivation of EGFR ²² Show member pathways Apoptosis and survival BAD phosphorylation ²² BAD Phosphorylation ⁶³ Chemotaxis CXCR4 signaling pathway ²² Development Alpha-2 adrenergic receptor activation of ERK ²²	12.52	VAV1 PTPRC LCK FYN
17	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁶	12.5	ZAP70 VAV1 PTPN6 LCK FYN
18	Prolactin Signaling Pathway ¹ ³⁶ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.45	ZAP70 VAV1 PTPN6 FYN
19	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	12.35	ZAP70 VAV1 PTPRC LCK FYN CSK
20	TCR signaling (REACTOME) ⁶⁵ Show member pathways Downstream TCR signaling ⁶⁵	12.34	ZAP70 PTPRJ PTPRC LCK CSK
21	B Cell Receptor Signaling Pathway (sino) ⁶⁶ Show member pathways B Cell Receptor Signaling Pathway ⁶⁶	12.26	ZAP70 VAV1 PTPRC PTPN6 LYN LCK
22	B cell receptor signaling pathway (KEGG) ¹ Show member pathways B cell receptor signaling pathway ³⁶ B Cell Receptor Signaling Pathway ¹	12.26	VAV1 PTPRC PTPN6 LYN LCK FYN
23	Cell surface interactions at the vascular wall ⁶⁵ Show member pathways Fibronectin matrix formation ⁶⁵ PECAM1 interactions ⁶⁵ Tie2 Signaling ⁶⁵	12.22	PTPN6 LYN LCK FYN
24	Pathogenic Escherichia coli infection ³⁶	12.21	PTPN6 LYN FYN
25	Regulation of actin dynamics for phagocytic cup formation ⁶⁵ Show member pathways Fcgamma receptor (FCGR) dependent phagocytosis ⁶⁵ RHO GTPases Activate WASPs and WAVEs ⁶⁵	12.21	VAV1 LYN FYN
26	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	12.17	VAV1 PTPN6 LYN FYN
27	G beta-gamma signalling through PI3Kgamma ⁶⁵ Show member pathways G-protein beta-gamma signalling ⁶⁵ GPVI-mediated activation cascade ⁶⁵	12.16	VAV1 PTPN6 LYN LCK FYN
28	Tyrosine Kinases / Adaptors ⁴	12.13	ZAP70 LYN LCK FYN CSK
29	CD28 co-stimulation ⁶⁵ Show member pathways Activation of AKT2 ⁶⁵ CD28 dependent PI3K/Akt signaling ⁶⁵ CD28 dependent Vav1 pathway ⁶⁵ Costimulation by the CD28 family ⁶⁵ VEGFR2 mediated vascular permeability ⁶⁵	12.12	VAV1 PTPN6 LYN LCK FYN CSK
30	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	12.02	LYN LCK FYN
31	Yersinia infection ³⁶	11.97	ZAP70 VAV1 LCK
32	EPHA forward signaling ¹ Show member pathways EPHA-mediated growth cone collapse ⁶⁵ Ephrin A reverse signaling ¹ EphrinA-EPHA pathway ¹ EphrinA-EphR Signaling ⁶³	11.95	LYN LCK FYN
33	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁵ Show member pathways B-Cell Receptor Complex ⁶³ CD22 mediated BCR regulation ⁶⁵ CLEC7A (Dectin-1) induces NFAT activation ⁶⁵ FCERI mediated Ca+2 mobilization ⁶⁵	11.95	VAV1 PTPN6 LYN FYN
34	MAP Kinase Signaling ⁴	11.94	LYN LCK FYN
35	Jak-Stat Signaling Pathway (sino) ⁶⁶	11.91	PTPRC PTPN6 LYN LCK FYN
36	Reelin Pathway (Cajal-Retzius cells) ⁶³	11.9	ZAP70 VAV1 FYN
37	NF-kappa B signaling pathway ³⁶	11.89	ZAP70 LYN LCK
38	Translocation of ZAP-70 to Immunological synapse ⁶⁵ Show member pathways Generation of second messenger molecules ⁶⁵ PD-1 signaling ⁶⁵ Phosphorylation of CD3 and TCR zeta chains ⁶⁵	11.88	ZAP70 PTPRJ PTPRC PTPN6 LCK CSK
39	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.87	PTPRC PTPN6 LYN
40	Fc gamma R-mediated phagocytosis ³⁶	11.84	VAV1 PTPRC LYN
41	NF-kB (NFkB) Pathway ⁶⁶	11.77	ZAP70 LYN LCK FYN
42	Adherens junction ³⁶	11.76	PTPRJ PTPN6 FYN ACP1
43	CTLA4 Signaling ⁶³	11.72	ZAP70 LCK FYN
44	Signaling events mediated by PTP1B ¹	11.59	LYN LCK FYN CSK
45	amb2 Integrin signaling ¹	11.54	LYN LCK FYN
46	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.53	LYN LCK FYN
47	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.53	ZAP70 VAV1 PTPRC PTPN6 LCK FYN
48	Thromboxane A2 receptor signaling ¹	11.51	LYN LCK FYN
49	Immune response_Role of integrins in NK cells cytotoxicity ²²	11.5	VAV1 PTPN6 LYN
50	Interferon type I signaling pathways ¹	11.47	ZAP70 VAV1 PTPRC PTPN6 LCK FYN

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GO Terms for Cd45 Deficiency

Cellular components related to Cd45 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.97	ZAP70 VAV1 PTPRJ PTPRC LYN LCK
2	extracellular exosome	GO:0070062	9.87	PTPRJ PTPRC PTPN6 LYN LCK CSK
3	extrinsic component of cytoplasmic side of plasma membrane	GO:0031234	9.43	LYN LCK FYN
4	cell-cell junction	GO:0005911	9.35	ZAP70 VAV1 PTPRJ PTPN6 CSK
5	immunological synapse	GO:0001772	9.33	ZAP70 PTPRJ LCK
6	membrane raft	GO:0045121	9.1	ZAP70 PTPRC LYN LCK FYN CSK

Biological processes related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show all 41)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	9.98	ZAP70 LYN FYN CSK
2	phosphorylation	GO:0016310	9.98	ZAP70 LYN LCK FYN CSK
3	protein phosphorylation	GO:0006468	9.97	ZAP70 LYN LCK FYN CSK
4	negative regulation of cell proliferation	GO:0008285	9.94	PTPRJ PTPN6 LYN CSK
5	adaptive immune response	GO:0002250	9.91	ZAP70 LYN FYN CSK
6	intracellular signal transduction	GO:0035556	9.88	ZAP70 VAV1 PTPN6 LYN FYN
7	regulation of cell proliferation	GO:0042127	9.85	LYN LCK FYN
8	dephosphorylation	GO:0016311	9.84	PTPRJ PTPRC PTPN6
9	leukocyte migration	GO:0050900	9.84	PTPN6 LYN LCK FYN
10	Fc-gamma receptor signaling pathway involved in phagocytosis	GO:0038096	9.82	VAV1 LYN FYN
11	positive regulation of protein kinase B signaling	GO:0051897	9.81	VAV1 PTPRJ LCK FYN
12	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.8	LYN LCK FYN
13	protein autophosphorylation	GO:0046777	9.8	ZAP70 LYN FYN CSK
14	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.77	PTPN6 LYN FYN
15	protein dephosphorylation	GO:0006470	9.77	PTPRJ PTPRC PTPN6 LCK ACP1
16	negative regulation of ERK1 and ERK2 cascade	GO:0070373	9.75	PTPRC LYN CSK
17	B cell receptor signaling pathway	GO:0050853	9.73	PTPRC PTPN6 LYN LCK
18	T cell activation	GO:0042110	9.72	ZAP70 VAV1 PTPRC
19	peptidyl-tyrosine dephosphorylation	GO:0035335	9.71	PTPRJ PTPRC PTPN6 ACP1
20	negative regulation of MAP kinase activity	GO:0043407	9.7	PTPRJ PTPN6 LYN
21	negative regulation of interleukin-6 production	GO:0032715	9.68	PTPN6 CSK
22	positive regulation of Ras protein signal transduction	GO:0046579	9.68	VAV1 LYN
23	regulation of ERK1 and ERK2 cascade	GO:0070372	9.67	PTPN6 LYN
24	regulation of defense response to virus by virus	GO:0050690	9.67	LCK FYN
25	calcium-mediated signaling using intracellular calcium source	GO:0035584	9.66	PTPRJ PTPRC
26	cellular response to peptide hormone stimulus	GO:0071375	9.66	FYN CSK
27	negative regulation of T cell receptor signaling pathway	GO:0050860	9.65	PTPRJ PTPN6
28	positive regulation of T cell differentiation	GO:0045582	9.65	ZAP70 PTPRC
29	cellular response to extracellular stimulus	GO:0031668	9.65	PTPRC LYN
30	platelet activation	GO:0030168	9.65	VAV1 PTPN6 LYN LCK FYN
31	negative regulation of peptidyl-tyrosine phosphorylation	GO:0050732	9.63	PTPRC PTPN6
32	regulation of release of sequestered calcium ion into cytosol	GO:0051279	9.63	PTPN6 LYN
33	peptidyl-tyrosine autophosphorylation	GO:0038083	9.63	LYN LCK FYN
34	T cell receptor signaling pathway	GO:0050852	9.63	ZAP70 PTPRJ PTPRC LCK FYN CSK
35	negative thymic T cell selection	GO:0045060	9.62	ZAP70 PTPRC
36	T cell differentiation	GO:0030217	9.62	ZAP70 VAV1 PTPRC LCK
37	positive thymic T cell selection	GO:0045059	9.61	ZAP70 PTPRC
38	positive regulation of alpha-beta T cell proliferation	GO:0046641	9.6	ZAP70 PTPRC
39	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	GO:1905451	9.56	PTPRJ PTPRC
40	peptidyl-tyrosine phosphorylation	GO:0018108	9.43	ZAP70 PTPN6 LYN LCK FYN CSK
41	T cell costimulation	GO:0031295	9.1	VAV1 PTPN6 LYN LCK FYN CSK

Molecular functions related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show all 21)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.3	ZAP70 VAV1 PTPRJ PTPRC PTPN6 LYN
2	ATP binding	GO:0005524	9.99	ZAP70 LYN LCK FYN CSK
3	protein kinase binding	GO:0019901	9.86	PTPRJ PTPRC PTPN6 LCK
4	kinase activity	GO:0016301	9.85	ZAP70 LYN LCK FYN CSK
5	protein kinase activity	GO:0004672	9.83	ZAP70 LYN LCK FYN CSK
6	signaling receptor binding	GO:0005102	9.81	PTPRC LYN LCK FYN
7	phosphatase activity	GO:0016791	9.7	PTPRJ PTPRC PTPN6
8	phosphoprotein phosphatase activity	GO:0004721	9.62	PTPRJ PTPRC PTPN6 ACP1
9	SH2 domain binding	GO:0042169	9.58	PTPN6 LCK
10	ephrin receptor binding	GO:0046875	9.58	LYN FYN
11	phosphatidylinositol 3-kinase binding	GO:0043548	9.57	LCK FYN
12	protein tyrosine phosphatase activity	GO:0004725	9.56	PTPRJ PTPRC PTPN6 ACP1
13	transmembrane receptor protein tyrosine phosphatase activity	GO:0005001	9.55	PTPRC PTPN6
14	platelet-derived growth factor receptor binding	GO:0005161	9.54	PTPRJ LYN
15	CD4 receptor binding	GO:0042609	9.49	LCK FYN
16	T cell receptor binding	GO:0042608	9.48	LCK FYN
17	phosphotyrosine residue binding	GO:0001784	9.46	ZAP70 VAV1 PTPN6 LCK
18	phosphorylation-dependent protein binding	GO:0140031	9.4	PTPN6 LYN
19	CD8 receptor binding	GO:0042610	9.37	LCK FYN
20	protein tyrosine kinase activity	GO:0004713	9.35	ZAP70 LYN LCK FYN CSK
21	non-membrane spanning protein tyrosine kinase activity	GO:0004715	9.02	ZAP70 LYN LCK FYN CSK

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Sources for Cd45 Deficiency

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