Cd45 Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CD4001 MIFTS: 28	Cd45 Deficiency Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Cd45 Deficiency

MalaCards integrated aliases for Cd45 Deficiency:

Name: Cd45 Deficiency ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060014

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Summaries for Cd45 Deficiency

Disease Ontology : ¹² A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age.

MalaCards based summary : Cd45 Deficiency is related to severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive and autoimmune cardiomyopathy. An important gene associated with Cd45 Deficiency is PTPN6 (Protein Tyrosine Phosphatase Non-Receptor Type 6), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include t cells and nk cells, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Cd45 Deficiency

Diseases related to Cd45 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)

#	Related Disease	Score	Top Affiliating Genes
1	severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive	11.5
2	autoimmune cardiomyopathy	10.0	LCK FYN
3	alzheimer disease	9.9
4	t cell deficiency	9.8	ZAP70 PTPRC
5	combined t cell and b cell immunodeficiency	9.8	ZAP70 PTPRC LCK
6	t-cell acute lymphoblastic leukemia	9.6	VAV1 PTPRC LCK
7	co-trimoxazole allergy	9.6	LYN LCK FYN
8	leukemia, chronic myeloid	9.5	PTPRC PTPN6 LYN LCK
9	wiskott-aldrich syndrome	9.5	ZAP70 VAV1 FYN
10	t-cell lymphoblastic leukemia/lymphoma	9.4	ZAP70 VAV1 PTPRC LCK
11	severe combined immunodeficiency	9.4	ZAP70 PTPRC LCK FYN
12	common variable immunodeficiency	9.3	ZAP70 VAV1 LCK
13	acute promyelocytic leukemia	9.2	VAV1 PTPRC PTPN6 LYN
14	leukemia, chronic lymphocytic	9.2	ZAP70 PTPRC LYN LCK

Graphical network of the top 20 diseases related to Cd45 Deficiency:

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Symptoms & Phenotypes for Cd45 Deficiency

GenomeRNAi Phenotypes related to Cd45 Deficiency according to GeneCards Suite gene sharing:

²⁶ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-3	10.36	LCK
2	Decreased viability	GR00107-A-1	10.36	ZAP70
3	Decreased viability	GR00221-A-1	10.36	FYN LCK ZAP70 CSK
4	Decreased viability	GR00221-A-2	10.36	FYN LCK VAV1 ZAP70
5	Decreased viability	GR00221-A-3	10.36	LCK VAV1 CSK LYN
6	Decreased viability	GR00221-A-4	10.36	VAV1
7	Decreased viability	GR00240-S-1	10.36	FYN
8	Decreased viability	GR00249-S	10.36	ZAP70
9	Decreased viability	GR00301-A	10.36	LCK
10	Decreased viability	GR00342-S-1	10.36	LCK
11	Decreased viability	GR00342-S-3	10.36	LCK
12	Decreased viability	GR00386-A-1	10.36	LCK VAV1
13	Decreased cell migration	GR00055-A-1	9.63	LCK LYN PTPN6 ZAP70
14	Decreased cell migration	GR00055-A-3	9.63	LYN PTPN6
15	Increased viability	GR00342-S-1	9.02	LYN ZAP70
16	Increased viability	GR00342-S-2	9.02	LYN ZAP70
17	Increased viability	GR00342-S-3	9.02	LYN

MGI Mouse Phenotypes related to Cd45 Deficiency:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.85	CSK FYN ICAM4 LCK LYN PTPN6
2	endocrine/exocrine gland	MP:0005379	9.8	CSK FYN LCK PTPN6 PTPRC VAV1
3	immune system	MP:0005387	9.65	ACP1 CSK FYN LCK LYN PTPN6
4	respiratory system	MP:0005388	9.1	CSK LYN PTPN6 PTPRC PTPRJ ZAP70

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Drugs & Therapeutics for Cd45 Deficiency

Search Clinical Trials , NIH Clinical Center for Cd45 Deficiency

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Genetic Tests for Cd45 Deficiency

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Anatomical Context for Cd45 Deficiency

MalaCards organs/tissues related to Cd45 Deficiency:

⁴⁰

T Cells, Nk Cells

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Publications for Cd45 Deficiency

Articles related to Cd45 Deficiency:

(show all 13)

#	Title	Authors	PMID	Year
1	CD45 in human physiology and clinical medicine. ⁶¹	Rheinlander A...Bommhardt U	29366662	2018
2	GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis. ⁶¹	Novak J...Fajka-Boja R	24231767	2014
3	Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. ⁶¹	Stepanek O...Brdicka T	21543337	2011
4	Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. ⁶¹	Hesslein DG...Lanier LL	21245479	2011
5	CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. ⁶¹	Zhu Y...Tan J	21273420	2011
6	CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes. ⁶¹	Lai JC...Johnson P	20624943	2010
7	CD45 regulates thymocyte survival during development in fetal thymic organ culture. ⁶¹	Ferguson BV...Ostergaard HL	19765855	2010
8	Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest. ⁶¹	Moore GT...d'Apice AJ	18155296	2008
9	Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. ⁶¹	Kung C...Thomas ML	10700239	2000
10	Surface expression of hemopoietic cell phosphatase fails to complement CD45 deficiency and inhibits TCR-mediated signal transduction in a Jurkat T cell clone. ⁶¹	Musci MA...Koretzky GA	9029091	1997
11	Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone. ⁶¹	Motto DG...Koretzky GA	7931069	1994
12	Activation of CD45-deficient T cell clones by lectin mitogens but not anti-Thy-1. ⁶¹	Pingel JT...Thomas ML	7908828	1994
13	CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli. ⁶¹	Weaver CT...Thomas ML	1652055	1991

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Genes for Cd45 Deficiency

Genes related to Cd45 Deficiency (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	9.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	6.84	DISEASES inferred ¹⁵
3	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6.4	DISEASES inferred ¹⁵
4	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	6.37	DISEASES inferred ¹⁵
5	CSK	C-Terminal Src Kinase	Protein Coding	6.01	DISEASES inferred ¹⁵
6	ACP1	Acid Phosphatase 1	Protein Coding	5.98	GeneCards inferred via : Publications (show sections)
7	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	5.58	DISEASES inferred ¹⁵
8	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	5.58	DISEASES inferred ¹⁵
9	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	5.41	DISEASES inferred ¹⁵
10	ICAM4	Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)	Protein Coding	5.11	DISEASES inferred ¹⁵
11	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	5.09	DISEASES inferred ¹⁵

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Variations for Cd45 Deficiency

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Expression for Cd45 Deficiency

Search GEO for disease gene expression data for Cd45 Deficiency.

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Pathways for Cd45 Deficiency

Pathways related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 65)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.9	ZAP70 VAV1 PTPRJ PTPRC PTPN6 LYN
2	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.28	VAV1 PTPN6 LYN LCK FYN CSK
3	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.28	ZAP70 VAV1 PTPRJ PTPRC PTPN6 LYN
4	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	13.25	VAV1 PTPN6 LYN LCK FYN CSK
5	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.12	VAV1 PTPRC LYN LCK FYN
6	GAB1 signalosome ⁶⁵ Show member pathways Constitutive Signaling by Aberrant PI3K in Cancer ⁶⁵ Negative regulation of the PI3K/AKT network ⁶⁵ PI3K/AKT activation ⁶⁵ PI3K/AKT Signaling in Cancer ⁶⁵ PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ⁶⁵ PIP3 activates AKT signaling ⁶⁵ Role of LAT2/NTAL/LAB on calcium mobilization ⁶⁵	13.05	VAV1 LYN LCK FYN CSK
7	TCR Signaling (Qiagen) ⁶³ Show member pathways ITK and TCR Signaling ⁶³ PDGF Pathway ⁶³ PKC-Theta Pathway ⁶³ TCR Signaling ⁶³	12.85	ZAP70 VAV1 PTPRC LYN LCK FYN
8	MAPK Erk Pathway ⁶⁶ Show member pathways Actin Dynamics Signaling Pathway ⁶⁶ G Protein coupled Receptors Signaling ⁶⁶	12.84	VAV1 LYN LCK ICAM4 FYN
9	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.77	ZAP70 VAV1 LYN FYN
10	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.71	VAV1 PTPN6 LYN LCK FYN
11	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.64	ZAP70 VAV1 LYN FYN
12	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.62	ZAP70 VAV1 PTPRC LYN LCK FYN
13	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁶	12.57	VAV1 PTPRC PTPN6 LYN FYN
14	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.57	ZAP70 VAV1 PTPRC PTPN6 LCK FYN
15	NF-kappaB Signaling ⁴	12.55	ZAP70 PTPRC PTPN6 LYN LCK
16	Development Dopamine D2 receptor transactivation of EGFR ²² Show member pathways Apoptosis and survival BAD phosphorylation ²² BAD Phosphorylation ⁶³ Chemotaxis CXCR4 signaling pathway ²² Development Alpha-2 adrenergic receptor activation of ERK ²²	12.52	VAV1 PTPRC LCK FYN
17	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁶	12.5	ZAP70 VAV1 PTPN6 LCK FYN
18	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.45	ZAP70 VAV1 PTPN6 FYN
19	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.44	PTPRC PTPN6 LYN LCK FYN
20	B Cell Receptor Signaling Pathway (sino) ⁶⁶ Show member pathways B Cell Receptor Signaling Pathway ⁶⁶	12.4	ZAP70 VAV1 PTPRC PTPN6 LYN LCK
21	TCR signaling (REACTOME) ⁶⁵ Show member pathways TCR signaling ⁶⁵	12.34	ZAP70 PTPRJ PTPRC LCK CSK
22	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	12.33	ZAP70 VAV1 PTPRC LCK FYN CSK
23	B cell receptor signaling pathway (KEGG) ³⁶ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.26	VAV1 PTPRC PTPN6 LYN LCK FYN
24	Cell surface interactions at the vascular wall ⁶⁵ Show member pathways Fibronectin matrix formation ⁶⁵ PECAM1 interactions ⁶⁵ Tie2 Signaling ⁶⁵	12.22	PTPN6 LYN LCK FYN
25	Regulation of actin dynamics for phagocytic cup formation ⁶⁵ Show member pathways Fcgamma receptor (FCGR) dependent phagocytosis ⁶⁵ RHO GTPases Activate WASPs and WAVEs ⁶⁵	12.21	VAV1 LYN FYN
26	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	12.17	VAV1 PTPN6 LYN FYN
27	G beta-gamma signalling through PI3Kgamma ⁶⁵ Show member pathways G-protein beta-gamma signalling ⁶⁵ GPVI-mediated activation cascade ⁶⁵	12.15	VAV1 PTPN6 LYN LCK FYN
28	CD28 co-stimulation ⁶⁵ Show member pathways Activation of AKT2 ⁶⁵ CD28 dependent PI3K/Akt signaling ⁶⁵ CD28 dependent Vav1 pathway ⁶⁵ Costimulation by the CD28 family ⁶⁵ VEGFR2 mediated vascular permeability ⁶⁵	12.15	VAV1 PTPN6 LYN LCK FYN CSK
29	Tyrosine Kinases / Adaptors ⁴	12.13	ZAP70 LYN LCK FYN CSK
30	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	12.03	LYN LCK FYN
31	Yersinia infection ³⁶	11.97	ZAP70 VAV1 LCK
32	EPHA forward signaling ¹ Show member pathways EPHA-mediated growth cone collapse ⁶⁵ Ephrin A reverse signaling ¹ EphrinA-EPHA pathway ¹ EphrinA-EphR Signaling ⁶³	11.95	LYN LCK FYN
33	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁵ Show member pathways B-Cell Receptor Complex ⁶³ CD22 mediated BCR regulation ⁶⁵ CLEC7A (Dectin-1) induces NFAT activation ⁶⁵ FCERI mediated Ca+2 mobilization ⁶⁵	11.95	VAV1 PTPN6 LYN FYN
34	MAP Kinase Signaling ⁴	11.94	LYN LCK FYN
35	NF-kB(NFkB) Pathway ⁶⁶	11.92	ZAP70 LYN LCK FYN
36	Reelin Pathway (Cajal-Retzius cells) ⁶³	11.91	ZAP70 VAV1 FYN
37	NF-kappa B signaling pathway ³⁶	11.9	ZAP70 LYN LCK
38	Translocation of ZAP-70 to Immunological synapse ⁶⁵ Show member pathways Generation of second messenger molecules ⁶⁵ PD-1 signaling ⁶⁵ Phosphorylation of CD3 and TCR zeta chains ⁶⁵	11.88	ZAP70 PTPRJ PTPRC PTPN6 LCK CSK
39	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.87	PTPRC PTPN6 LYN
40	Fc gamma R-mediated phagocytosis ³⁶	11.84	VAV1 PTPRC LYN
41	Adherens junction ³⁶	11.74	PTPRJ PTPN6 FYN ACP1
42	CTLA4 Signaling ⁶³	11.72	ZAP70 LCK FYN
43	Signaling events mediated by PTP1B ¹	11.58	LYN LCK FYN CSK
44	amb2 Integrin signaling ¹	11.54	LYN LCK FYN
45	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.53	LYN LCK FYN
46	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.53	ZAP70 VAV1 PTPRC PTPN6 LCK FYN
47	Thromboxane A2 receptor signaling ¹	11.51	LYN LCK FYN
48	Immune response_Role of integrins in NK cells cytotoxicity ²²	11.5	VAV1 PTPN6 LYN
49	Interferon type I signaling pathways ¹	11.47	ZAP70 VAV1 PTPRC PTPN6 LCK FYN
50	Class I PI3K signaling events ¹	11.45	VAV1 LYN LCK FYN

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GO Terms for Cd45 Deficiency

Cellular components related to Cd45 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane	GO:0016020	10.1	ZAP70 PTPRJ PTPRC PTPN6 LYN LCK
2	plasma membrane	GO:0005886	10.02	ZAP70 VAV1 PTPRJ PTPRC LYN LCK
3	extracellular exosome	GO:0070062	9.87	PTPRJ PTPRC PTPN6 LYN LCK CSK
4	extrinsic component of cytoplasmic side of plasma membrane	GO:0031234	9.46	ZAP70 LYN LCK FYN
5	immunological synapse	GO:0001772	9.43	ZAP70 PTPRJ LCK
6	cell-cell junction	GO:0005911	9.35	ZAP70 VAV1 PTPRJ PTPN6 CSK
7	membrane raft	GO:0045121	9.1	ZAP70 PTPRC LYN LCK FYN CSK

Biological processes related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show all 43)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell differentiation	GO:0030154	10.05	ZAP70 PTPN6 LYN LCK FYN
2	phosphorylation	GO:0016310	10	ZAP70 LYN LCK FYN CSK
3	innate immune response	GO:0045087	9.99	ZAP70 LYN LCK FYN
4	viral process	GO:0016032	9.98	PTPRC LYN LCK FYN
5	protein phosphorylation	GO:0006468	9.98	ZAP70 LYN LCK FYN CSK
6	negative regulation of cell proliferation	GO:0008285	9.95	PTPRJ PTPN6 LYN CSK
7	adaptive immune response	GO:0002250	9.94	ZAP70 LYN FYN CSK
8	intracellular signal transduction	GO:0035556	9.93	ZAP70 VAV1 PTPN6 LYN FYN
9	regulation of cell proliferation	GO:0042127	9.87	ZAP70 LYN LCK FYN
10	leukocyte migration	GO:0050900	9.86	PTPN6 LYN LCK FYN
11	dephosphorylation	GO:0016311	9.85	PTPRJ PTPRC PTPN6
12	Fc-gamma receptor signaling pathway involved in phagocytosis	GO:0038096	9.81	VAV1 LYN FYN
13	positive regulation of protein kinase B signaling	GO:0051897	9.81	VAV1 PTPRJ LCK FYN
14	protein autophosphorylation	GO:0046777	9.8	ZAP70 LYN FYN CSK
15	protein dephosphorylation	GO:0006470	9.8	PTPRJ PTPRC PTPN6 LCK ACP1
16	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.79	PTPN6 LYN FYN
17	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.78	ZAP70 LYN LCK FYN
18	negative regulation of ERK1 and ERK2 cascade	GO:0070373	9.77	PTPRC LYN CSK
19	B cell receptor signaling pathway	GO:0050853	9.76	PTPRC PTPN6 LYN LCK
20	peptidyl-tyrosine dephosphorylation	GO:0035335	9.73	PTPRJ PTPRC PTPN6 ACP1
21	T cell activation	GO:0042110	9.72	ZAP70 VAV1 PTPRC
22	negative regulation of MAP kinase activity	GO:0043407	9.7	PTPRJ PTPN6 LYN
23	negative regulation of interleukin-6 production	GO:0032715	9.69	PTPN6 CSK
24	positive regulation of Ras protein signal transduction	GO:0046579	9.68	VAV1 LYN
25	regulation of ERK1 and ERK2 cascade	GO:0070372	9.68	PTPN6 LYN
26	regulation of defense response to virus by virus	GO:0050690	9.68	LCK FYN
27	negative regulation of T cell receptor signaling pathway	GO:0050860	9.67	PTPRJ PTPN6
28	calcium-mediated signaling using intracellular calcium source	GO:0035584	9.67	PTPRJ PTPRC
29	T cell differentiation	GO:0030217	9.67	ZAP70 VAV1 PTPRC LCK
30	positive regulation of T cell differentiation	GO:0045582	9.66	ZAP70 PTPRC
31	cellular response to peptide hormone stimulus	GO:0071375	9.66	FYN CSK
32	cellular response to extracellular stimulus	GO:0031668	9.65	PTPRC LYN
33	platelet activation	GO:0030168	9.65	VAV1 PTPN6 LYN LCK FYN
34	regulation of release of sequestered calcium ion into cytosol	GO:0051279	9.63	PTPN6 LYN
35	negative regulation of peptidyl-tyrosine phosphorylation	GO:0050732	9.63	PTPRC PTPN6
36	T cell receptor signaling pathway	GO:0050852	9.63	ZAP70 PTPRJ PTPRC LCK FYN CSK
37	negative thymic T cell selection	GO:0045060	9.62	ZAP70 PTPRC
38	positive thymic T cell selection	GO:0045059	9.62	ZAP70 PTPRC
39	peptidyl-tyrosine autophosphorylation	GO:0038083	9.62	ZAP70 LYN LCK FYN
40	positive regulation of alpha-beta T cell proliferation	GO:0046641	9.61	ZAP70 PTPRC
41	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	GO:1905451	9.58	PTPRJ PTPRC
42	peptidyl-tyrosine phosphorylation	GO:0018108	9.43	ZAP70 PTPN6 LYN LCK FYN CSK
43	T cell costimulation	GO:0031295	9.1	VAV1 PTPN6 LYN LCK FYN CSK

Molecular functions related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	9.88	ZAP70 LYN LCK FYN CSK
2	protein kinase binding	GO:0019901	9.86	PTPRJ PTPRC PTPN6 LCK
3	protein kinase activity	GO:0004672	9.85	ZAP70 LYN LCK FYN CSK
4	signaling receptor binding	GO:0005102	9.77	ZAP70 PTPRC LYN LCK FYN
5	phosphatase activity	GO:0016791	9.71	PTPRJ PTPRC PTPN6
6	phosphoprotein phosphatase activity	GO:0004721	9.62	PTPRJ PTPRC PTPN6 ACP1
7	SH2 domain binding	GO:0042169	9.58	PTPN6 LCK
8	ephrin receptor binding	GO:0046875	9.58	LYN FYN
9	phosphatidylinositol 3-kinase binding	GO:0043548	9.57	LCK FYN
10	protein tyrosine phosphatase activity	GO:0004725	9.56	PTPRJ PTPRC PTPN6 ACP1
11	transmembrane receptor protein tyrosine phosphatase activity	GO:0005001	9.55	PTPRC PTPN6
12	platelet-derived growth factor receptor binding	GO:0005161	9.52	PTPRJ LYN
13	CD4 receptor binding	GO:0042609	9.51	LCK FYN
14	T cell receptor binding	GO:0042608	9.49	LCK FYN
15	phosphotyrosine residue binding	GO:0001784	9.46	ZAP70 VAV1 PTPN6 LCK
16	CD8 receptor binding	GO:0042610	9.43	LCK FYN
17	phosphorylation-dependent protein binding	GO:0140031	9.4	PTPN6 LYN
18	protein tyrosine kinase activity	GO:0004713	9.35	ZAP70 LYN LCK FYN CSK
19	non-membrane spanning protein tyrosine kinase activity	GO:0004715	9.02	ZAP70 LYN LCK FYN CSK

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Sources for Cd45 Deficiency

¹ BioSystems

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia