Cd45 Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CD4001 MIFTS: 30	Cd45 Deficiency Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Cd45 Deficiency

MalaCards integrated aliases for Cd45 Deficiency:

Name: Cd45 Deficiency ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060014

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Summaries for Cd45 Deficiency

Disease Ontology : ¹² A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age.

MalaCards based summary : Cd45 Deficiency is related to severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive and autoimmune cardiomyopathy. An important gene associated with Cd45 Deficiency is PTPN6 (Protein Tyrosine Phosphatase Non-Receptor Type 6), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and PAK Pathway. Affiliated tissues include t cells and nk cells, and related phenotypes are Reduced mammosphere formation and immune system

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Related Diseases for Cd45 Deficiency

Diseases related to Cd45 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)

#	Related Disease	Score	Top Affiliating Genes
1	severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive	11.5
2	autoimmune cardiomyopathy	10.5	ZAP70 LCK
3	cd8 deficiency, familial	10.4	ZAP70 CD8A
4	epithelial malignant thymoma	10.3	LCK CD5
5	dendritic cell thymoma	10.3	LCK CD5
6	spindle cell thymoma	10.3	LCK CD5
7	metal allergy	10.2	CD8A CD4
8	polyclonal hypergammaglobulinemia	10.2	CD8A CD4
9	colon lymphoma	10.1	PTPRC CD5
10	melkersson-rosenthal syndrome	10.1	PTPRC CD8A CD4
11	b cell prolymphocytic leukemia	10.0	ZAP70 CD5
12	cll/sll	9.9	ZAP70 CD5
13	epidural neoplasm	9.9	PTPRC CD5
14	alzheimer disease	9.9
15	reticulum cell sarcoma	9.8	PTPRC CD4
16	mantle cell lymphoma	9.8	SYK PTPRC CD5
17	thymus lipoma	9.6	PTPRC CD8A CD5 CD4
18	thymoma	9.6	THY1 PTPRC LCK CD5
19	immune system organ benign neoplasm	9.6	PTPRC CD8A CD5 CD4
20	lymphoma, non-hodgkin, familial	9.6	SYK PTPRC CXCL12 CD5
21	leukemia, chronic lymphocytic	9.4	ZAP70 SYK CXCL12 CD5
22	hematologic cancer	9.3	ZAP70 SYK PTPRC CXCL12 CD5
23	human immunodeficiency virus type 1	9.1	LCK FYN CXCL12 CD4

Graphical network of the top 20 diseases related to Cd45 Deficiency:

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Symptoms & Phenotypes for Cd45 Deficiency

GenomeRNAi Phenotypes related to Cd45 Deficiency according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.1	CD5 FYN LCK PTPRC SYK ZAP70

MGI Mouse Phenotypes related to Cd45 Deficiency:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10.2	ACKR2 ACP1 CCR9 CD4 CD5 CD8A
2	hematopoietic system	MP:0005397	10.18	CCR9 CD4 CD5 CD8A CXCL12 DLL1
3	endocrine/exocrine gland	MP:0005379	10.14	CCR9 CD4 CD8A DLL1 FUT1 FYN
4	cellular	MP:0005384	10.13	ACP1 CD4 CD8A CXCL12 DLL1 FYN
5	nervous system	MP:0003631	9.85	CD4 CD5 CD8A CXCL12 DLL1 FYN
6	integument	MP:0010771	9.8	ACKR2 CD4 CD5 CD8A FYN PTPN6
7	no phenotypic analysis	MP:0003012	9.5	CD4 CD5 CXCL12 FYN PTPRC PTPRJ
8	normal	MP:0002873	9.28	CD4 CD5 CD8A CXCL12 DLL1 PTPRC

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Drugs & Therapeutics for Cd45 Deficiency

Search Clinical Trials , NIH Clinical Center for Cd45 Deficiency

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Genetic Tests for Cd45 Deficiency

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Anatomical Context for Cd45 Deficiency

MalaCards organs/tissues related to Cd45 Deficiency:

⁴¹

T Cells, Nk Cells

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Publications for Cd45 Deficiency

Articles related to Cd45 Deficiency:

(show all 13)

#	Title	Authors	PMID	Year
1	CD45 in human physiology and clinical medicine. ³⁸	Rheinlander A...Bommhardt U	29366662	2018
2	GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis. ³⁸	Novak J...Fajka-Boja R	24231767	2014
3	Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. ³⁸	Stepanek O...Brdicka T	21543337	2011
4	Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. ³⁸	Hesslein DG...Lanier LL	21245479	2011
5	CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. ³⁸	Zhu Y...Tan J	21273420	2011
6	CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes. ³⁸	Lai JC...Johnson P	20624943	2010
7	CD45 regulates thymocyte survival during development in fetal thymic organ culture. ³⁸	Ferguson BV...Ostergaard HL	19765855	2010
8	Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest. ³⁸	Moore GT...d'Apice AJ	18155296	2008
9	Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. ³⁸	Kung C...Thomas ML	10700239	2000
10	Surface expression of hemopoietic cell phosphatase fails to complement CD45 deficiency and inhibits TCR-mediated signal transduction in a Jurkat T cell clone. ³⁸	Musci MA...Koretzky GA	9029091	1997
11	Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone. ³⁸	Motto DG...Koretzky GA	7931069	1994
12	Activation of CD45-deficient T cell clones by lectin mitogens but not anti-Thy-1. ³⁸	Pingel JT...Thomas ML	7908828	1994
13	CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli. ³⁸	Weaver CT...Thomas ML	1652055	1991

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Genes for Cd45 Deficiency

Genes related to Cd45 Deficiency (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	19.94	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	16.27	DISEASES inferred ¹⁵
3	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	15.54	DISEASES inferred ¹⁵
4	FUT1	Fucosyltransferase 1 (H Blood Group)	Protein Coding	15.38	DISEASES inferred ¹⁵
5	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	15.2	DISEASES inferred ¹⁵
6	ACKR2	Atypical Chemokine Receptor 2	Protein Coding	14.52	DISEASES inferred ¹⁵
7	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	14.24	DISEASES inferred ¹⁵
8	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	13.99	DISEASES inferred ¹⁵
9	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	13.69	DISEASES inferred ¹⁵
10	CD8A	CD8a Molecule	Protein Coding	13.49	DISEASES inferred ¹⁵
11	CD4	CD4 Molecule	Protein Coding	13.22	DISEASES inferred ¹⁵
12	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	13.15	DISEASES inferred ¹⁵
13	CD5	CD5 Molecule	Protein Coding	13.14	DISEASES inferred ¹⁵
14	ACP1	Acid Phosphatase 1	Protein Coding	6.5	GeneCards inferred via : Publications (show sections)
15	CCR9	C-C Motif Chemokine Receptor 9	Protein Coding	4.84	DISEASES inferred ¹⁵
16	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4.02	DISEASES inferred ¹⁵
17	THY1	Thy-1 Cell Surface Antigen	Protein Coding	3.56	DISEASES inferred ¹⁵

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Variations for Cd45 Deficiency

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Expression for Cd45 Deficiency

Search GEO for disease gene expression data for Cd45 Deficiency.

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Pathways for Cd45 Deficiency

Pathways related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 55)

#	Super pathways	Score	Top Affiliating Genes
1	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁶	13.43	ZAP70 SYK PTPRJ PTPRC PTPN6 LCK
2	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.3	PTPRJ PTPRC PTPN6 FYN DLL1 CXCL12
3	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13.01	ZAP70 SYK LCK FYN CXCL12
4	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ ITK and TCR Signaling ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴	12.91	ZAP70 SYK PTPRC LCK FYN CD8A
5	Allograft rejection ³⁷ ¹ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.85	ZAP70 PTPRC LCK FYN CXCL12 CD8A
6	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.63	ZAP70 SYK PTPRC LCK FYN CD4
7	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.54	ZAP70 LCK DLL1 CD4
8	NF-kappaB Signaling ⁴	12.54	ZAP70 SYK PTPRC PTPN6 LCK CXCL12
9	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁷ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁷	12.53	SYK PTPRC PTPN6 FYN
10	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁷	12.52	ZAP70 SYK PTPN6 LCK FYN
11	Development Dopamine D2 receptor transactivation of EGFR ²² Show member pathways Apoptosis and survival BAD phosphorylation ²² BAD Phosphorylation ⁶⁴ Chemotaxis CXCR4 signaling pathway ²² Development Alpha-2 adrenergic receptor activation of ERK ²²	12.51	PTPRC LCK FYN CXCL12
12	T cell receptor signaling pathway ³⁷ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁷ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.49	ZAP70 PTPRC PTPN6 LCK FYN CD8A
13	B cell receptor signaling pathway (KEGG) ¹ Show member pathways B cell receptor signaling pathway ³⁷ BCR signaling pathway ¹	12.43	SYK PTPRC PTPN6 LCK FYN
14	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.41	PTPRC PTPN6 LCK FYN CXCL12
15	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.39	ZAP70 SYK PTPRC LCK FYN CD4
16	TCR signaling (REACTOME) ⁶⁶ Show member pathways TCR signaling ⁶⁶	12.37	ZAP70 PTPRJ PTPRC LCK CD4
17	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways B Cell Receptor Signaling Pathway ⁶⁷	12.33	ZAP70 SYK PTPRC PTPN6 LCK CD4
18	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁵ Show member pathways Chemokine receptors bind chemokines ⁶⁶ Viral protein interaction with cytokine and cytokine receptor ³⁷	12.21	CXCL12 CCR9 ACKR2
19	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ VEGFR2 mediated vascular permeability ⁶⁶	12.21	PTPN6 LCK FYN CD4
20	G beta-gamma signalling through PI3Kgamma ⁶⁶ Show member pathways G-protein beta-gamma signalling ⁶⁶ GPVI-mediated activation cascade ⁶⁶	12.15	SYK PTPN6 LCK FYN
21	Tyrosine Kinases / Adaptors ⁴	12.13	ZAP70 SYK LCK FYN
22	Cell adhesion molecules (CAMs) ³⁷	12.05	PTPRC CD8A CD4
23	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	12.01	SYK LCK FYN
24	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12.01	THY1 PTPRC CD8A CD5 CD4
25	Osteoclast differentiation ³⁷	11.99	SYK LCK FYN
26	NF-kappa B signaling pathway ³⁷	11.95	ZAP70 SYK LCK CXCL12
27	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.92	LCK CD8A CD4
28	Immune response IL-2 activation and signaling pathway ²² Show member pathways Immune response IL-3 activation and signaling pathway ²²	11.91	SYK PTPN6 LCK
29	Jak-Stat Signaling Pathway (sino) ⁶⁷	11.9	PTPRC PTPN6 LCK FYN CXCL12
30	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁶ Show member pathways B-Cell Receptor Complex ⁶⁴ CD22 mediated BCR regulation ⁶⁶ CLEC7A (Dectin-1) induces NFAT activation ⁶⁶ FCERI mediated Ca+2 mobilization ⁶⁶	11.89	SYK PTPN6 FYN
31	S-1P Stimulated Signaling ⁶⁴	11.88	ZAP70 LCK CD4
32	Translocation of ZAP-70 to Immunological synapse ⁶⁶ Show member pathways Generation of second messenger molecules ⁶⁶ PD-1 signaling ⁶⁶ Phosphorylation of CD3 and TCR zeta chains ⁶⁶	11.88	ZAP70 PTPRJ PTPRC PTPN6 LCK CD4
33	Hematopoietic cell lineage ³⁷	11.84	CD8A CD5 CD4
34	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.83	THY1 PTPRC CD8A CD4
35	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters ⁶⁶ Show member pathways Inhibition of Ribosome Biogenesis by p19(ARF) ⁶⁴ Nef and signal transduction ⁶⁶ Nef Mediated CD4 Down-regulation ⁶⁶ Nef Mediated CD8 Down-regulation ⁶⁶ Nef mediated downregulation of CD28 cell surface expression ⁶⁶ Nef mediated downregulation of MHC class I complex cell surface expression ⁶⁶ The role of Nef in HIV-1 replication and disease pathogenesis ⁶⁶	11.8	LCK FYN CD4
36	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.78	THY1 PTPRC CD8A CD4
37	Adherens junction ³⁷	11.76	PTPRJ PTPN6 FYN ACP1
38	NF-kB (NFkB) Pathway ⁶⁷	11.71	ZAP70 SYK LCK FYN CD4
39	G-protein signaling_RhoA regulation pathway ²²	11.68	ZAP70 LCK FYN CXCL12
40	PDGFR-beta signaling pathway ¹	11.61	PTPRJ LCK FYN ACP1
41	B Cell Development Pathways ⁶⁵	11.59	THY1 PTPRC CD5 CD4
42	DNA damage_Role of Brca1 and Brca2 in DNA repair ²²	11.57	ZAP70 PTPRC LCK FYN CD8A CD4
43	Interferon type I signaling pathways ¹	11.57	ZAP70 PTPRC PTPN6 LCK FYN
44	amb2 Integrin signaling ¹	11.53	THY1 LCK FYN
45	CXCR4-mediated signaling events ¹	11.51	PTPRC PTPN6 LCK FYN CXCL12 CD4
46	Thromboxane A2 receptor signaling ¹	11.5	SYK LCK FYN
47	Alpha-synuclein signaling ¹	11.34	SYK LCK FYN
48	Primary immunodeficiency ³⁷	11.29	ZAP70 PTPRC LCK CD8A CD4
49	CTLA4 Signaling ⁶⁴	11.28	ZAP70 SYK LCK FYN CD8A CD4
50	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.2	ZAP70 PTPRC PTPN6 LCK FYN CD8A

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GO Terms for Cd45 Deficiency

Cellular components related to Cd45 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.96	THY1 PTPRJ PTPRC FUT1 DLL1 CD8A
2	cell surface	GO:0009986	9.83	THY1 PTPRJ PTPRC CD4 CCR9
3	immunological synapse	GO:0001772	9.58	ZAP70 PTPRJ LCK
4	membrane raft	GO:0045121	9.5	ZAP70 THY1 PTPRC LCK FYN DLL1
5	T cell receptor complex	GO:0042101	9.46	ZAP70 SYK CD8A CD4
6	external side of plasma membrane	GO:0009897	9.23	THY1 PTPRC CXCL12 CD8A CD5 CD4
7	membrane	GO:0016020	10.27	ZAP70 THY1 SYK PTPRJ PTPRC PTPN6
8	plasma membrane	GO:0005886	10.17	ZAP70 THY1 SYK PTPRJ PTPRC LCK

Biological processes related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show all 42)

#	Name	GO ID	Score	Top Affiliating Genes
1	adaptive immune response	GO:0002250	9.97	ZAP70 SYK FYN CD4
2	cell surface receptor signaling pathway	GO:0007166	9.95	SYK PTPRC FYN CD8A CD4
3	protein autophosphorylation	GO:0046777	9.91	ZAP70 THY1 SYK FYN
4	B cell receptor signaling pathway	GO:0050853	9.88	SYK PTPRC PTPN6 LCK
5	positive regulation of MAPK cascade	GO:0043410	9.86	PTPRJ PTPRC CD4
6	platelet activation	GO:0030168	9.86	SYK PTPN6 LCK FYN
7	cell chemotaxis	GO:0060326	9.83	CXCL12 CCR9 ACKR2
8	peptidyl-tyrosine dephosphorylation	GO:0035335	9.83	PTPRJ PTPRC PTPN6 ACP1
9	chemokine-mediated signaling pathway	GO:0070098	9.8	CXCL12 CCR9 ACKR2
10	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.8	LCK FYN CD8A CD4
11	protein dephosphorylation	GO:0006470	9.8	PTPRJ PTPRC PTPN6 LCK ACP1
12	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.78	SYK PTPRJ PTPRC CD4
13	peptidyl-tyrosine phosphorylation	GO:0018108	9.77	ZAP70 SYK PTPN6 LCK FYN
14	regulation of defense response to virus by virus	GO:0050690	9.74	LCK FYN CD4
15	calcium-mediated signaling using intracellular calcium source	GO:0035584	9.69	PTPRJ PTPRC
16	positive regulation of T cell activation	GO:0050870	9.69	THY1 LCK CD4
17	positive regulation of T cell differentiation	GO:0045582	9.68	ZAP70 PTPRC
18	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.68	THY1 LCK
19	positive regulation of cell adhesion mediated by integrin	GO:0033630	9.68	SYK PTPN6
20	negative regulation of protein tyrosine kinase activity	GO:0061099	9.67	THY1 PTPRC
21	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.67	PTPRC CD4
22	negative regulation of peptidyl-tyrosine phosphorylation	GO:0050732	9.66	PTPRC PTPN6
23	detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	9.65	FYN CXCL12
24	positive thymic T cell selection	GO:0045059	9.64	ZAP70 PTPRC
25	negative thymic T cell selection	GO:0045060	9.64	ZAP70 PTPRC
26	positive regulation of alpha-beta T cell differentiation	GO:0046638	9.63	ZAP70 SYK
27	regulation of phagocytosis	GO:0050764	9.63	SYK PTPRC
28	negative regulation of T cell receptor signaling pathway	GO:0050860	9.63	THY1 PTPRJ PTPN6
29	enzyme linked receptor protein signaling pathway	GO:0007167	9.62	SYK CD4
30	T cell costimulation	GO:0031295	9.62	PTPN6 LCK FYN CD5
31	positive regulation of calcium-mediated signaling	GO:0050850	9.61	ZAP70 SYK CD4
32	positive regulation of gamma-delta T cell differentiation	GO:0045588	9.6	SYK PTPRC
33	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	GO:1905451	9.59	PTPRJ PTPRC
34	beta selection	GO:0043366	9.58	ZAP70 SYK
35	T cell activation	GO:0042110	9.46	ZAP70 PTPRC CD8A CD4
36	positive regulation of alpha-beta T cell proliferation	GO:0046641	9.43	ZAP70 SYK PTPRC
37	regulation of B cell differentiation	GO:0045577	9.35	PTPN6
38	T cell differentiation	GO:0030217	9.26	ZAP70 PTPRC LCK CD4
39	T cell receptor signaling pathway	GO:0050852	9.17	ZAP70 THY1 PTPRJ PTPRC LCK FYN
40	immune system process	GO:0002376	10.06	ZAP70 SYK FYN CD8A CD4
41	viral process	GO:0016032	10.01	SYK LCK FYN CXCL12 CD4
42	immune response	GO:0006955	10.01	ZAP70 CXCL12 CD8A CD4 CCR9 ACKR2

Molecular functions related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.85	PTPRC LCK FYN CXCL12 CD4
2	protein tyrosine kinase activity	GO:0004713	9.73	ZAP70 SYK LCK FYN
3	phosphatase activity	GO:0016791	9.71	PTPRJ PTPRC PTPN6
4	integrin binding	GO:0005178	9.7	THY1 SYK CXCL12
5	protein tyrosine phosphatase activity	GO:0004725	9.62	PTPRJ PTPRC PTPN6 ACP1
6	chemokine binding	GO:0019956	9.58	CCR9 ACKR2
7	C-C chemokine binding	GO:0019957	9.58	CCR9 ACKR2
8	SH2 domain binding	GO:0042169	9.58	SYK PTPN6 LCK
9	C-C chemokine receptor activity	GO:0016493	9.57	CCR9 ACKR2
10	phosphatidylinositol 3-kinase binding	GO:0043548	9.56	LCK FYN
11	phosphoprotein phosphatase activity	GO:0004721	9.56	PTPRJ PTPRC PTPN6 ACP1
12	chemokine receptor activity	GO:0004950	9.55	CCR9 ACKR2
13	transmembrane receptor protein tyrosine phosphatase activity	GO:0005001	9.51	PTPRC PTPN6
14	CD4 receptor binding	GO:0042609	9.49	LCK FYN
15	T cell receptor binding	GO:0042608	9.48	LCK FYN
16	non-membrane spanning protein tyrosine kinase activity	GO:0004715	9.46	ZAP70 SYK LCK FYN
17	CD8 receptor binding	GO:0042610	9.37	LCK FYN
18	phosphotyrosine residue binding	GO:0001784	9.26	ZAP70 SYK PTPN6 LCK
19	protein kinase binding	GO:0019901	9.23	THY1 SYK PTPRJ PTPRC PTPN6 LCK

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Sources for Cd45 Deficiency

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