Cd45 Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CD4001 MIFTS: 29	Cd45 Deficiency Categories: Immune diseases
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Aliases & Classifications for Cd45 Deficiency

MalaCards integrated aliases for Cd45 Deficiency:

Name: Cd45 Deficiency ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060014

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Summaries for Cd45 Deficiency

Disease Ontology : ¹² A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age.

MalaCards based summary : Cd45 Deficiency is related to severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive and spindle cell thymoma. An important gene associated with Cd45 Deficiency is PTPN6 (Protein Tyrosine Phosphatase, Non-Receptor Type 6), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and PAK Pathway. Affiliated tissues include t cells, and related phenotypes are Decreased cell migration and Decreased substrate adherent cell growth

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Related Diseases for Cd45 Deficiency

Diseases related to Cd45 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)

#	Related Disease	Score	Top Affiliating Genes
1	severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive	11.2
2	spindle cell thymoma	10.4	CD5 LCK
3	dendritic cell thymoma	10.4	CD5 LCK
4	epithelial malignant thymoma	10.3	CD5 LCK
5	colon lymphoma	10.2	CD5 PTPRC
6	b cell linker protein deficiency	10.2	CD5 SYK
7	b cell prolymphocytic leukemia	10.1	CD5 ZAP70
8	cll/sll	10.0	CD5 ZAP70
9	lymphoplasmacytic lymphoma	9.8	CD5 CXCL12
10	epidural neoplasm	9.8	CD5 PTPRC
11	alzheimer disease	9.7
12	neuronitis	9.7
13	thymoma	9.5	CD5 LCK PTPRC THY1
14	lymphoma, non-hodgkin, familial	9.5	CD5 CXCL12 PTPRC SYK
15	leukemia, chronic lymphocytic	9.2	CD5 CXCL12 SYK ZAP70
16	hematologic cancer	9.1	CD5 CXCL12 PTPRC SYK ZAP70

Graphical network of the top 20 diseases related to Cd45 Deficiency:

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Symptoms & Phenotypes for Cd45 Deficiency

GenomeRNAi Phenotypes related to Cd45 Deficiency according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased cell migration	GR00055-A-1	9.65	LCK PLCG1 PTPN6 SYK ZAP70
2	Decreased substrate adherent cell growth	GR00193-A-2	9.55	FYN LCK SYK
3	Decreased substrate adherent cell growth	GR00193-A-3	9.55	LCK
4	Decreased substrate adherent cell growth	GR00193-A-4	9.55	LCK
5	Reduced mammosphere formation	GR00396-S	9.43	CD5 FYN LCK PTPRC SYK ZAP70
6	shRNA abundance <= 50%	GR00343-S	9.28	ACKR2 ACP1 CCR9 FYN LCK PTPRC

MGI Mouse Phenotypes related to Cd45 Deficiency:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.03	CD5 PTPRJ CXCL12 SYK DLL1 ZAP70
2	endocrine/exocrine gland	MP:0005379	10.02	CCR9 PTPRC SYK DLL1 FUT1 ZAP70
3	immune system	MP:0005387	10	CD5 PTPRJ CXCL12 SYK DLL1 ZAP70
4	no phenotypic analysis	MP:0003012	9.43	PTPRC CD5 PTPRJ CXCL12 SYK FYN
5	normal	MP:0002873	9.17	PTPRC CD5 PTPRJ CXCL12 THY1 DLL1

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Drugs & Therapeutics for Cd45 Deficiency

Search Clinical Trials , NIH Clinical Center for Cd45 Deficiency

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Genetic Tests for Cd45 Deficiency

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Anatomical Context for Cd45 Deficiency

MalaCards organs/tissues related to Cd45 Deficiency:

⁴¹

T Cells

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Publications for Cd45 Deficiency

Articles related to Cd45 Deficiency:

#	Title	Authors	Year
1	CD45 deficiency drives amyloid-I^ peptide oligomers and neuronal loss in Alzheimer's disease mice. ( 21273420 )	Zhu Y....Tan J.	2011
2	Surface expression of hemopoietic cell phosphatase fails to complement CD45 deficiency and inhibits TCR-mediated signal transduction in a Jurkat T cell clone. ( 9029091 )	Musci M.A....Koretzky G.A.	1997
3	Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone. ( 7931069 )	Motto D.G....Koretzky G.A.	1994

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Genes for Cd45 Deficiency

Genes related to Cd45 Deficiency (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTPN6	Protein Tyrosine Phosphatase, Non-Receptor Type 6	Protein Coding	20.26	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	16.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	16.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	FUT1	Fucosyltransferase 1 (H Blood Group)	Protein Coding	15.71	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PTPRJ	Protein Tyrosine Phosphatase, Receptor Type J	Protein Coding	15.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	ACKR2	Atypical Chemokine Receptor 2	Protein Coding	14.9	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	14.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	14.12	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	13.94	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	13.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	CD5	CD5 Molecule	Protein Coding	13.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	PLCG1	Phospholipase C Gamma 1	Protein Coding	13.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	ACP1	Acid Phosphatase 1	Protein Coding	6.57	GeneCards inferred via : Publications (show sections)
14	CCR9	C-C Motif Chemokine Receptor 9	Protein Coding	5.03	DISEASES inferred ¹⁵
15	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4.24	DISEASES inferred ¹⁵
16	THY1	Thy-1 Cell Surface Antigen	Protein Coding	3.88	DISEASES inferred ¹⁵

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Variations for Cd45 Deficiency

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Expression for Cd45 Deficiency

Search GEO for disease gene expression data for Cd45 Deficiency.

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Pathways for Cd45 Deficiency

Pathways related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Super pathways	Score	Top Affiliating Genes
1	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁶	13.4	FYN LCK PLCG1 PTPN6 PTPRC PTPRJ
2	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.26	CCR9 CXCL12 DLL1 FYN PLCG1 PTPN6
3	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13.04	CXCL12 FYN LCK PLCG1 SYK ZAP70
4	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.88	CXCL12 FYN PLCG1 SYK ZAP70
5	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴ TCR Signaling ⁶⁴	12.88	FYN LCK PLCG1 PTPRC SYK ZAP70
6	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.83	CCR9 CXCL12 FYN LCK PLCG1 PTPRC
7	IL-2 Pathway ⁶⁴ Show member pathways HMGB1 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TREM1 Pathway ⁶⁴	12.76	FYN LCK PLCG1 PTPRC SYK
8	Downstream signaling events of B Cell Receptor (BCR) ⁶⁶ Show member pathways Activation of RAS in B cells ⁶⁶ Signaling by the B Cell Receptor (BCR) ⁶⁶	12.71	FYN LCK PLCG1 PTPN6 SYK
9	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.57	FYN LCK PLCG1 SYK ZAP70
10	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁷ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁷	12.56	FYN PLCG1 PTPN6 PTPRC SYK
11	NF-kappaB Signaling ⁴	12.53	CXCL12 LCK PTPN6 PTPRC SYK ZAP70
12	Development Dopamine D2 receptor transactivation of EGFR ²² Show member pathways Apoptosis and survival BAD phosphorylation ²² BAD Phosphorylation ⁶⁴ Chemotaxis CXCR4 signaling pathway ²² Development Alpha-2 adrenergic receptor activation of ERK ²²	12.52	CXCL12 FYN LCK PTPRC
13	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁷	12.46	FYN LCK PLCG1 PTPN6 SYK ZAP70
14	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.44	FYN PLCG1 PTPN6 ZAP70
15	Th17 cell differentiation ³⁷ Show member pathways Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.41	DLL1 LCK PLCG1 ZAP70
16	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.38	FYN LCK PLCG1 PTPN6 PTPRC ZAP70
17	TCR signaling (REACTOME) ⁶⁶ Show member pathways TCR signaling ⁶⁶	12.34	LCK PLCG1 PTPRC PTPRJ ZAP70
18	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.33	FYN LCK PLCG1 PTPRC SYK ZAP70
19	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways B Cell Receptor Signaling Pathway ⁶⁷	12.31	LCK PTPN6 PTPRC SYK ZAP70
20	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.31	FYN LCK PLCG1 PTPN6 PTPRC SYK
21	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	12.22	FYN LCK PLCG1 PTPN6
22	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	12.16	FYN PLCG1 PTPN6 SYK
23	G beta-gamma signalling through PI3Kgamma ⁶⁶ Show member pathways G-protein beta-gamma signalling ⁶⁶ GPVI-mediated activation cascade ⁶⁶	12.13	FYN LCK PTPN6 SYK
24	Tyrosine Kinases / Adaptors ⁴	12.11	FYN LCK SYK ZAP70
25	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	12.02	FYN LCK SYK
26	Osteoclast differentiation ³⁷	12	FYN LCK SYK
27	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁵ Show member pathways Chemokine receptors bind chemokines ⁶⁶	11.95	ACKR2 CCR9 CXCL12
28	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.95	CD5 PTPRC THY1
29	EPHA forward signaling ¹ Show member pathways EPHA-mediated growth cone collapse ⁶⁶ Ephrin A reverse signaling ¹ EphrinA-EPHA pathway ¹ EphrinA-EphR Signaling ⁶⁴	11.94	FYN LCK PLCG1
30	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁶ Show member pathways B-Cell Receptor Complex ⁶⁴ CD22 mediated BCR regulation ⁶⁶ CLEC7A (Dectin-1) induces NFAT activation ⁶⁶ FCERI mediated Ca+2 mobilization ⁶⁶	11.93	FYN PLCG1 PTPN6 SYK
31	Immune response IL-2 activation and signaling pathway ²² Show member pathways Immune response IL-3 activation and signaling pathway ²²	11.91	LCK PTPN6 SYK
32	S-1P Stimulated Signaling ⁶⁴	11.88	LCK PLCG1 ZAP70
33	Jak-Stat Signaling Pathway ⁶⁷	11.87	CXCL12 FYN LCK PTPN6 PTPRC
34	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.86	PLCG1 PTPN6 PTPRC
35	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.83	FYN PLCG1 PTPN6
36	Fc gamma R-mediated phagocytosis ³⁷	11.82	PLCG1 PTPRC SYK
37	NF-kappa B signaling pathway ³⁷	11.81	CXCL12 LCK PLCG1 SYK ZAP70
38	Adherens junction ³⁷	11.73	ACP1 FYN PTPN6 PTPRJ
39	NF-kB (NFkB) Pathway ⁶⁷	11.72	FYN LCK SYK ZAP70
40	CXCR4-mediated signaling events ¹	11.68	CXCL12 FYN LCK PTPN6 PTPRC
41	Translocation of ZAP-70 to Immunological synapse ⁶⁶ Show member pathways Generation of second messenger molecules ⁶⁶ PD-1 signaling ⁶⁶ Phosphorylation of CD3 and TCR zeta chains ⁶⁶	11.67	LCK PLCG1 PTPN6 PTPRC PTPRJ ZAP70
42	CTLA4 Signaling ⁶⁴	11.62	FYN LCK PLCG1 SYK ZAP70
43	Role of phospholipids in phagocytosis ⁶⁶ Show member pathways FCGR activation ⁶⁶	11.61	FYN PLCG1 SYK
44	B Cell Development Pathways ⁶⁵	11.57	CD5 PTPRC THY1
45	amb2 Integrin signaling ¹	11.52	FYN LCK THY1
46	Thromboxane A2 receptor signaling ¹	11.49	FYN LCK SYK
47	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.47	FYN LCK PLCG1 PTPN6 PTPRC ZAP70
48	Interferon type I signaling pathways ¹	11.46	FYN LCK PTPN6 PTPRC ZAP70
49	Class I PI3K signaling events ¹	11.44	FYN LCK PLCG1
50	PDGFR-beta signaling pathway ¹	11.39	ACP1 FYN LCK PLCG1 PTPRJ

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GO Terms for Cd45 Deficiency

Cellular components related to Cd45 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.97	ACKR2 CCR9 CD5 CXCL12 DLL1 FYN
2	integral component of plasma membrane	GO:0005887	9.92	ACKR2 CCR9 CD5 DLL1 FUT1 PTPRC
3	external side of plasma membrane	GO:0009897	9.73	CD5 CXCL12 PTPRC THY1
4	cell-cell junction	GO:0005911	9.67	PLCG1 PTPN6 PTPRJ ZAP70
5	T cell receptor complex	GO:0042101	9.46	SYK ZAP70
6	immunological synapse	GO:0001772	9.43	LCK PTPRJ ZAP70
7	extrinsic component of cytoplasmic side of plasma membrane	GO:0031234	9.26	FYN LCK SYK ZAP70
8	membrane raft	GO:0045121	9.1	DLL1 FYN LCK PTPRC THY1 ZAP70
9	membrane	GO:0016020	10.25	ACKR2 ACP1 CCR9 CD5 DLL1 FUT1

Biological processes related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show all 26)

#	Name	GO ID	Score	Top Affiliating Genes
1	intracellular signal transduction	GO:0035556	9.95	FYN PLCG1 PTPN6 SYK ZAP70
2	regulation of cell proliferation	GO:0042127	9.88	FYN LCK SYK ZAP70
3	leukocyte migration	GO:0050900	9.84	FYN LCK PLCG1 PTPN6
4	protein autophosphorylation	GO:0046777	9.83	FYN SYK THY1 ZAP70
5	Fc-gamma receptor signaling pathway involved in phagocytosis	GO:0038096	9.79	FYN PLCG1 SYK
6	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.78	FYN LCK SYK ZAP70
7	platelet activation	GO:0030168	9.76	FYN LCK PTPN6 SYK
8	chemokine-mediated signaling pathway	GO:0070098	9.74	ACKR2 CCR9 CXCL12
9	peptidyl-tyrosine dephosphorylation	GO:0035335	9.73	ACP1 PTPN6 PTPRC PTPRJ
10	B cell receptor signaling pathway	GO:0050853	9.71	LCK PTPN6 PTPRC SYK
11	T cell differentiation	GO:0030217	9.69	LCK PTPRC ZAP70
12	protein dephosphorylation	GO:0006470	9.65	ACP1 LCK PTPN6 PTPRC PTPRJ
13	positive regulation of focal adhesion assembly	GO:0051894	9.63	PTPRJ THY1
14	positive regulation of T cell activation	GO:0050870	9.62	LCK THY1
15	T cell costimulation	GO:0031295	9.62	CD5 FYN LCK PTPN6
16	positive regulation of calcium-mediated signaling	GO:0050850	9.61	SYK ZAP70
17	positive regulation of cell adhesion mediated by integrin	GO:0033630	9.61	PTPN6 SYK
18	positive regulation of alpha-beta T cell differentiation	GO:0046638	9.59	SYK ZAP70
19	detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	9.58	CXCL12 FYN
20	positive regulation of alpha-beta T cell proliferation	GO:0046641	9.56	SYK ZAP70
21	peptidyl-tyrosine phosphorylation	GO:0018108	9.55	FYN LCK PTPN6 SYK ZAP70
22	negative regulation of T cell receptor signaling pathway	GO:0050860	9.54	PTPN6 PTPRJ THY1
23	beta selection	GO:0043366	9.49	SYK ZAP70
24	peptidyl-tyrosine autophosphorylation	GO:0038083	9.26	FYN LCK SYK ZAP70
25	T cell receptor signaling pathway	GO:0050852	9.17	FYN LCK PLCG1 PTPRC PTPRJ THY1
26	cell differentiation	GO:0030154	10.08	DLL1 FYN LCK PTPN6 SYK ZAP70

Molecular functions related to Cd45 Deficiency according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.85	CXCL12 FYN LCK SYK ZAP70
2	protein tyrosine kinase activity	GO:0004713	9.73	FYN LCK SYK ZAP70
3	integrin binding	GO:0005178	9.72	CXCL12 SYK THY1
4	phosphoprotein phosphatase activity	GO:0004721	9.7	ACP1 PTPN6 PTPRJ
5	phosphatase activity	GO:0016791	9.67	ACP1 PTPN6 PTPRC PTPRJ
6	SH2 domain binding	GO:0042169	9.58	LCK PTPN6 SYK
7	chemokine receptor activity	GO:0004950	9.57	ACKR2 CCR9
8	phosphatidylinositol 3-kinase binding	GO:0043548	9.56	FYN LCK
9	protein tyrosine phosphatase activity	GO:0004725	9.56	ACP1 PTPN6 PTPRC PTPRJ
10	transmembrane receptor protein tyrosine phosphatase activity	GO:0005001	9.54	PTPN6 PTPRC
11	C-C chemokine receptor activity	GO:0016493	9.51	ACKR2 CCR9
12	T cell receptor binding	GO:0042608	9.49	FYN LCK
13	CD4 receptor binding	GO:0042609	9.48	FYN LCK
14	non-membrane spanning protein tyrosine kinase activity	GO:0004715	9.46	FYN LCK SYK ZAP70
15	CD8 receptor binding	GO:0042610	9.32	FYN LCK
16	phosphotyrosine residue binding	GO:0001784	9.26	LCK PTPN6 SYK ZAP70
17	protein kinase binding	GO:0019901	9.17	LCK PLCG1 PTPN6 PTPRC PTPRJ SYK

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