MCID: CD4008
MIFTS: 19

Cd4/cd8 T-Cell Ratio

Aliases & Classifications for Cd4/cd8 T-Cell Ratio

MalaCards integrated aliases for Cd4/cd8 T-Cell Ratio:

Name: Cd4/cd8 T-Cell Ratio 58

External Ids:

OMIM 58 601083

Summaries for Cd4/cd8 T-Cell Ratio

MalaCards based summary : Cd4/cd8 T-Cell Ratio is related to peritonitis and multiple sclerosis. An important gene associated with Cd4/cd8 T-Cell Ratio is IL16 (Interleukin 16). The drugs Calcium and Rosuvastatin Calcium have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow.

Description from OMIM: 601083

Related Diseases for Cd4/cd8 T-Cell Ratio

Diseases related to Cd4/cd8 T-Cell Ratio via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 peritonitis 10.2
2 multiple sclerosis 10.1
3 lymphoma, hodgkin, classic 10.1
4 aplastic anemia 10.1
5 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.1
6 joint disorders 10.1
7 leukemia 10.1
8 lymphoma 10.1
9 arthropathy 10.1
10 human immunodeficiency virus infectious disease 10.1
11 t-cell leukemia 10.1

Graphical network of the top 20 diseases related to Cd4/cd8 T-Cell Ratio:



Diseases related to Cd4/cd8 T-Cell Ratio

Symptoms & Phenotypes for Cd4/cd8 T-Cell Ratio

Clinical features from OMIM:

601083

Drugs & Therapeutics for Cd4/cd8 T-Cell Ratio

Drugs for Cd4/cd8 T-Cell Ratio (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
2 Rosuvastatin Calcium Phase 2 147098-20-2
3 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
4 Anti-Retroviral Agents Phase 2,Phase 1
5 Lipid Regulating Agents Phase 2
6 Antimetabolites Phase 2
7 Anticholesteremic Agents Phase 2
8 Hypolipidemic Agents Phase 2
9 Calcium, Dietary Phase 2
10
Metformin Approved Phase 1 657-24-9 14219 4091
11 Hypoglycemic Agents Phase 1
12
Ritonavir Approved, Investigational 155213-67-5 392622
13
Lopinavir Approved 192725-17-0 92727
14 Cytochrome P-450 Enzyme Inhibitors
15 Anti-HIV Agents
16
protease inhibitors
17 Anti-Infective Agents
18 Antiviral Agents
19 Cytochrome P-450 CYP3A Inhibitors
20 Reverse Transcriptase Inhibitors
21 HIV Protease Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rosuvastatin to Decrease Residual Immune Activation in HIV Infection Unknown status NCT01874743 Phase 2 Rosuvastatin 20 mg/day
2 Metformin Immunotherapy in HIV Infection Active, not recruiting NCT02659306 Phase 1 Metformin
3 Kaletra: Therapy With Double Protease Inhibitors Completed NCT01075191

Search NIH Clinical Center for Cd4/cd8 T-Cell Ratio

Genetic Tests for Cd4/cd8 T-Cell Ratio

Anatomical Context for Cd4/cd8 T-Cell Ratio

MalaCards organs/tissues related to Cd4/cd8 T-Cell Ratio:

42
T Cells, Bone, Bone Marrow, Lung, Heart, Lymph Node, Thymus

Publications for Cd4/cd8 T-Cell Ratio

Articles related to Cd4/cd8 T-Cell Ratio:

(show all 16)
# Title Authors Year
1
A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects. ( 28559274 )
2017
2
Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health? ( 29095912 )
2017
3
Comparative Impact of Suppressive Antiretroviral Regimens on the CD4/CD8 T-Cell Ratio: A Cohort Study. ( 26986155 )
2016
4
Baseline CD4/CD8 T-Cell Ratio Predicts Prompt Immune Restoration Upon cART Initiation. ( 27074946 )
2016
5
High interindividual variability in the CD4/CD8 T cell ratio and natalizumab concentration levels in the cerebrospinal fluid of patients with multiple sclerosis. ( 25603898 )
2015
6
Increased bone marrow (BM) plasma level of soluble CD30 and correlations with BM plasma level of interferon (IFN)-γ, CD4/CD8 T-cell ratio and disease severity in aplastic anemia. ( 25383872 )
2014
7
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice. ( 21483764 )
2011
8
CD4/CD8 T-cell ratio in peritoneal dialysis effluents predicts the outcome of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis. ( 19604230 )
2009
9
Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio. ( 19652940 )
2009
10
CD4/CD8 T-cell ratio predicts HIV infection in infants: the National Heart, Lung, and Blood Institute P2C2 Study. ( 17920669 )
2007
11
Is an increase in CD4/CD8 T-cell ratio in lymph node fine needle aspiration helpful for diagnosing Hodgkin lymphoma? A study of 85 lymph node FNAs with increased CD4/CD8 ratio. ( 16153296 )
2005
12
Patterns of CD4/CD8 T-cell ratio in dialysis effluents predict the long-term outcome of peritonitis in patients undergoing peritoneal dialysis. ( 12748353 )
2003
13
Relationship between CD4(+)/CD8(+) T cell ratio and T cell activation in multiple myeloma: reference to IL-16. ( 12191564 )
2002
14
A dominant role for the thymus and MHC genes in determining the peripheral CD4/CD8 T cell ratio in the rat. ( 10477560 )
1999
15
Genetic control of the CD4/CD8 T-cell ratio in humans. ( 7489409 )
1995
16
Persistent depletion of CD4+ T cells and inversion of the CD4/CD8 T cell ratio induced by anti-CD4 therapy. ( 1363476 )
1992

Variations for Cd4/cd8 T-Cell Ratio

Expression for Cd4/cd8 T-Cell Ratio

Search GEO for disease gene expression data for Cd4/cd8 T-Cell Ratio.

Pathways for Cd4/cd8 T-Cell Ratio

GO Terms for Cd4/cd8 T-Cell Ratio

Sources for Cd4/cd8 T-Cell Ratio

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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