MCID: CD4008
MIFTS: 18

Cd4/cd8 T-Cell Ratio

Aliases & Classifications for Cd4/cd8 T-Cell Ratio

MalaCards integrated aliases for Cd4/cd8 T-Cell Ratio:

Name: Cd4/cd8 T-Cell Ratio 57

External Ids:

OMIM 57 601083

Summaries for Cd4/cd8 T-Cell Ratio

MalaCards based summary : Cd4/cd8 T-Cell Ratio is related to peritonitis and multiple sclerosis. An important gene associated with Cd4/cd8 T-Cell Ratio is IL16 (Interleukin 16). The drugs Calcium, Dietary and Anticholesteremic Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and lung.

Description from OMIM: 601083

Related Diseases for Cd4/cd8 T-Cell Ratio

Diseases related to Cd4/cd8 T-Cell Ratio via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 peritonitis 10.2
2 multiple sclerosis 10.1
3 lymphoma, hodgkin, classic 10.1
4 aplastic anemia 10.1
5 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.1
6 leukemia 10.1
7 arthropathy 10.1
8 human immunodeficiency virus infectious disease 10.1
9 t-cell leukemia 10.1

Graphical network of the top 20 diseases related to Cd4/cd8 T-Cell Ratio:



Diseases related to Cd4/cd8 T-Cell Ratio

Symptoms & Phenotypes for Cd4/cd8 T-Cell Ratio

Clinical features from OMIM:

601083

Drugs & Therapeutics for Cd4/cd8 T-Cell Ratio

Drugs for Cd4/cd8 T-Cell Ratio (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Calcium, Dietary Phase 2
2 Anticholesteremic Agents Phase 2
3 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
4 Antimetabolites Phase 2
5 Rosuvastatin Calcium Phase 2 147098-20-2
6 Lipid Regulating Agents Phase 2
7 Hypolipidemic Agents Phase 2
8
Metformin Approved Phase 1 657-24-9 14219 4091
9 Hypoglycemic Agents Phase 1
10
Lopinavir Approved 192725-17-0 92727
11
Ritonavir Approved, Investigational 155213-67-5 392622
12 Cytochrome P-450 CYP3A Inhibitors
13 Anti-Infective Agents
14 Cytochrome P-450 Enzyme Inhibitors
15 HIV Protease Inhibitors
16 Antiviral Agents
17 Anti-HIV Agents
18
protease inhibitors
19 Anti-Retroviral Agents
20 Reverse Transcriptase Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rosuvastatin to Decrease Residual Immune Activation in HIV Infection Unknown status NCT01874743 Phase 2 Rosuvastatin 20 mg/day
2 Metformin Immunotherapy in HIV Infection Active, not recruiting NCT02659306 Phase 1 Metformin
3 Kaletra: Therapy With Double Protease Inhibitors Completed NCT01075191

Search NIH Clinical Center for Cd4/cd8 T-Cell Ratio

Genetic Tests for Cd4/cd8 T-Cell Ratio

Anatomical Context for Cd4/cd8 T-Cell Ratio

MalaCards organs/tissues related to Cd4/cd8 T-Cell Ratio:

41
T Cells, Bone, Lung, Heart, Lymph Node, Thymus, Bone Marrow

Publications for Cd4/cd8 T-Cell Ratio

Articles related to Cd4/cd8 T-Cell Ratio:

(show all 15)
# Title Authors Year
1
Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health? ( 29095912 )
2017
2
A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects. ( 28559274 )
2017
3
Comparative Impact of Suppressive Antiretroviral Regimens on the CD4/CD8 T-Cell Ratio: A Cohort Study. ( 26986155 )
2016
4
Baseline CD4/CD8 T-Cell Ratio Predicts Prompt Immune Restoration Upon cART Initiation. ( 27074946 )
2016
5
High interindividual variability in the CD4/CD8 T cell ratio and natalizumab concentration levels in the cerebrospinal fluid of patients with multiple sclerosis. ( 25603898 )
2015
6
Increased Bone Marrow (BM) Plasma Level of Soluble CD30 and Correlations with BM Plasma Level of Interferon (IFN)-I^, CD4/CD8 T-Cell Ratio and Disease Severity in Aplastic Anemia. ( 25383872 )
2014
7
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice. ( 21483764 )
2011
8
CD4/CD8 T-cell ratio in peritoneal dialysis effluents predicts the outcome of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis. ( 19604230 )
2009
9
CD4/CD8 T-cell ratio predicts HIV infection in infants: the National Heart, Lung, and Blood Institute P2C2 Study. ( 17920669 )
2007
10
Is an increase in CD4/CD8 T-cell ratio in lymph node fine needle aspiration helpful for diagnosing Hodgkin lymphoma? A study of 85 lymph node FNAs with increased CD4/CD8 ratio. ( 16153296 )
2005
11
Patterns of CD4/CD8 T-cell ratio in dialysis effluents predict the long-term outcome of peritonitis in patients undergoing peritoneal dialysis. ( 12748353 )
2003
12
Relationship between CD4(+)/CD8(+) T cell ratio and T cell activation in multiple myeloma: reference to IL-16. ( 12191564 )
2002
13
A dominant role for the thymus and MHC genes in determining the peripheral CD4/CD8 T cell ratio in the rat. ( 10477560 )
1999
14
Genetic control of the CD4/CD8 T-cell ratio in humans. ( 7489409 )
1995
15
Persistent depletion of CD4+ T cells and inversion of the CD4/CD8 T cell ratio induced by anti-CD4 therapy. ( 1363476 )
1992

Variations for Cd4/cd8 T-Cell Ratio

Expression for Cd4/cd8 T-Cell Ratio

Search GEO for disease gene expression data for Cd4/cd8 T-Cell Ratio.

Pathways for Cd4/cd8 T-Cell Ratio

GO Terms for Cd4/cd8 T-Cell Ratio

Sources for Cd4/cd8 T-Cell Ratio

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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