MCID: CD4008
MIFTS: 20

Cd4/cd8 T-Cell Ratio

Aliases & Classifications for Cd4/cd8 T-Cell Ratio

MalaCards integrated aliases for Cd4/cd8 T-Cell Ratio:

Name: Cd4/cd8 T-Cell Ratio 56

External Ids:

OMIM 56 601083

Summaries for Cd4/cd8 T-Cell Ratio

MalaCards based summary : Cd4/cd8 T-Cell Ratio is related to peritonitis and myelopathy, htlv-1-associated. An important gene associated with Cd4/cd8 T-Cell Ratio is IL16 (Interleukin 16). The drugs Abacavir and Lamivudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone.

More information from OMIM: 601083

Related Diseases for Cd4/cd8 T-Cell Ratio

Diseases related to Cd4/cd8 T-Cell Ratio via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 peritonitis 10.2
2 myelopathy, htlv-1-associated 10.1
3 lymphoma, hodgkin, classic 10.1
4 lymphoma, non-hodgkin, familial 10.1
5 aplastic anemia 10.1
6 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.1
7 adult t-cell leukemia 10.1
8 diffuse large b-cell lymphoma 10.1
9 lymphoproliferative syndrome 10.1
10 tropical spastic paraparesis 10.1
11 arthropathy 10.1
12 b-cell lymphoma 10.1
13 t-cell leukemia 10.1
14 htlv-1 associated myelopathy/tropical spastic paraparesis 10.1
15 spastic paraparesis 10.1

Graphical network of the top 20 diseases related to Cd4/cd8 T-Cell Ratio:



Diseases related to Cd4/cd8 T-Cell Ratio

Symptoms & Phenotypes for Cd4/cd8 T-Cell Ratio

Clinical features from OMIM:

601083

Drugs & Therapeutics for Cd4/cd8 T-Cell Ratio

Drugs for Cd4/cd8 T-Cell Ratio (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abacavir Approved, Investigational Phase 4 136470-78-5 65140 441300
2
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
3
Darunavir Approved Phase 4 635728-49-3, 206361-99-1 213039
4
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
5
Cobicistat Approved Phase 4 1004316-88-4
6
Dolutegravir Approved Phase 4 1051375-16-6 54726191
7
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
8 Anti-Infective Agents Phase 4
9 Cytochrome P-450 CYP3A Inhibitors Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Antiviral Agents Phase 4
12 Reverse Transcriptase Inhibitors Phase 4
13 HIV Integrase Inhibitors Phase 4
14 Integrase Inhibitors Phase 4
15 Anti-HIV Agents Phase 4
16
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
17 Rosuvastatin Calcium Phase 2 147098-20-2
18 Hypolipidemic Agents Phase 2
19 Anticholesteremic Agents Phase 2
20 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
21 Lipid Regulating Agents Phase 2
22 Antimetabolites Phase 2
23 Calcium, Dietary Phase 2
24
Metformin Approved Phase 1 657-24-9 14219 4091
25 Anti-Retroviral Agents Phase 1
26 Hypoglycemic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Is Dual Therapy as Effective as Triple Therapy Regarding CD4+/CD8+ Ratio Recovery and Improvement of Immune Activation and Inflammation in HIV-infected Patients With Consistent Plasma Viral Load Suppression (Tridual) Recruiting NCT03447873 Phase 4 Continue with triple therapy;Switch to DTG + 3TC;Switch to DRV/cobicistat + 3TC
2 Pilot Study of the Impact of Rosuvastatin Administration on Residual Chronic Immune Activation Under Antiretroviral Therapy: CESAR (Crestor En Sus Des AntiRétroviraux) Unknown status NCT01874743 Phase 2 Rosuvastatin 20 mg/day
3 The Effect of Metformin on HIV Reservoir Size in Non-diabetic Antiretroviral Therapy (ART) Treated Participants: the Lilac Study Active, not recruiting NCT02659306 Phase 1 Metformin

Search NIH Clinical Center for Cd4/cd8 T-Cell Ratio

Genetic Tests for Cd4/cd8 T-Cell Ratio

Anatomical Context for Cd4/cd8 T-Cell Ratio

MalaCards organs/tissues related to Cd4/cd8 T-Cell Ratio:

40
T Cells, B Cells, Bone, Lung, Bone Marrow, Lymph Node, Nk Cells

Publications for Cd4/cd8 T-Cell Ratio

Articles related to Cd4/cd8 T-Cell Ratio:

(show top 50) (show all 296)
# Title Authors PMID Year
1
Genetic control of the CD4/CD8 T-cell ratio in humans. 61 56
7489409 1995
2
CD4 and CD8 T lymphocyte inheritance. Evidence for major autosomal recessive genes. 56
10543402 1999
3
The CD4/CD8 ratio: message in a bottle? 56
7489396 1995
4
Genetic control of T-cell subset representation in inbred mice. 56
6606619 1983
5
Low CSF CD4/CD8+ T-cell proportions are associated with blood-CSF barrier dysfunction in limbic encephalitis. 61
31846897 2020
6
Impact of ART on dynamics of growth factors and cytokines in primary HIV infection. 61
31542514 2020
7
Effect of low dose naloxone on the immune system function of a patient undergoing video-assisted thoracoscopic resection of lung cancer with sufentanil controlled analgesia - a randomized controlled trial. 61
31856760 2019
8
CD4/CD8 + T cells, DC subsets, Foxp3, and IDO expression are predictive indictors of gastric cancer prognosis. 61
31631566 2019
9
CD4+ /CD8+ T-cell ratio correlates with the graft fate in pig-to-non-human primate islet xenotransplantation. 61
31642566 2019
10
Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa. 61
31358657 2019
11
Immune Biomarkers in the Prediction of Future Myocardial Infarction in People with HIV. 61
31414117 2019
12
NK cells in treated HIV-infected children display altered phenotype and function. 61
30735686 2019
13
Immunologic Features of Patients With Advanced Hepatocellular Carcinoma Before and During Sorafenib or Anti-programmed Death-1/Programmed Death-L1 Treatment. 61
31295151 2019
14
The evaluation of cellular immune function in elderly patients with systemic lupus erythematosus. 61
29172398 2019
15
Chronic arsenic exposure in drinking water interferes with the balances of T lymphocyte subpopulations as well as stimulates the functions of dendritic cells in vivo. 61
30889423 2019
16
Incomplete ART adherence is associated with higher inflammation in individuals who achieved virologic suppression in the START study. 61
31250552 2019
17
Immunological recovery in T-cell activation after sustained virologic response among HIV positive and HIV negative chronic Hepatitis C patients. 61
30835046 2019
18
Effect of Lactobacillus plantarum IS-10506 on blood lipopolysaccharide level and immune response in HIV-infected children. 61
31341568 2019
19
B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. 61
30896447 2019
20
TCR repertoire intratumor heterogeneity of CD4+ and CD8+ T cells in centers and margins of localized lung adenocarcinomas. 61
30151844 2019
21
CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age. 61
30686790 2019
22
Retrospective Study of Factors Potentially Influencing Occurrence of Cough in Slovak Patients with Sarcoidosis. 61
31281552 2019
23
Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study. 61
31869342 2019
24
Effect of low-dose cyclophosphamide, ACTH, and IVIG combination immunotherapy on neuroinflammation in pediatric-onset OMS: A retrospective pilot study. 61
29555260 2018
25
Reversal of T Cell Exhaustion by the First Donor Lymphocyte Infusion Is Associated with the Persistently Effective Antileukemic Responses in Patients with Relapsed AML after Allo-HSCT. 61
29649617 2018
26
Cytomegalovirus aggravates the autoimmune phenomenon in systemic autoimmune diseases. 61
29704668 2018
27
T cells establish and maintain CNS viral infection in HIV-infected humanized mice. 61
29863499 2018
28
Does simplification to dolutegravir-based dual regimens impact on the CD4+/CD8+ T-cell ratio? 61
29698323 2018
29
High-grade anal intraepithelial neoplasia is associated with HIV-1 RNA rectal shedding in virologically suppressed MSM. 61
29547439 2018
30
Alteration of CCR6+CD95+CD4+ naïve T cells in HIV-1 infected patients: Implication for clinical practice. 61
29454646 2018
31
The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques. 61
29553486 2018
32
Analysis of peripheral blood T-cell subsets and regulatory T-cells in multiple myeloma patients. 61
29729703 2018
33
Good's Syndrome-Association of the Late Onset Combined Immunodeficiency with Thymoma: Review of Literature and Case Report. 61
29512373 2018
34
[Modified Cheng's Juanbi Decoction reduces cAMP level of T lymphocytes in peripheral blood and CD4+/CD8+ T cell ratio among rats with adjuvant arthritis]. 61
29673452 2018
35
Age-Dependent Pre-Vaccination Immunity Affects the Immunogenicity of Varicella Zoster Vaccination in Middle-aged Adults. 61
29410671 2018
36
[X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia: report of a family and literature review]. 61
29342998 2018
37
Galectin-1 Restores Immune Tolerance to Liver Transplantation Through Activation of Hepatic Stellate Cells. 61
30032146 2018
38
Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA. 61
29364927 2018
39
High proportion of PD-1-expressing CD4+ T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence. 61
28762530 2017
40
Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health? 61
29095912 2017
41
T-cell regulation in Erythema Nodosum Leprosum. 61
28991896 2017
42
HIV-Infected Children Have Elevated Levels of PD-1+ Memory CD4 T Cells With Low Proliferative Capacity and High Inflammatory Cytokine Effector Functions. 61
28934428 2017
43
A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects. 61
28559274 2017
44
Prediction of graft-versus-host disease: a biomarker panel based on lymphocytes and cytokines. 61
28447161 2017
45
Characteristics of Good's Syndrome in China: A Systematic Review. 61
28639577 2017
46
Th1- and Th17-polarized immune infiltrates in eosinophilic fasciitis-A potential marker for histopathologic distinction from morphea. 61
28393380 2017
47
Japanese herbal medicine-induced pneumonitis: A review of 73 patients. 61
28274529 2017
48
Mixed T Cell Chimerism After Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia Using an Alemtuzumab-Containing Regimen Is Shaped by Persistence of Recipient CD8 T Cells. 61
27816648 2017
49
Rituximab-associated progressive multifocal leukoencephalopathy. 61
28225293 2017
50
Divergent Immunomodulation Capacity of Individual Myelin Peptides-Components of Liposomal Therapeutic against Multiple Sclerosis. 61
29085375 2017

Variations for Cd4/cd8 T-Cell Ratio

Expression for Cd4/cd8 T-Cell Ratio

Search GEO for disease gene expression data for Cd4/cd8 T-Cell Ratio.

Pathways for Cd4/cd8 T-Cell Ratio

GO Terms for Cd4/cd8 T-Cell Ratio

Sources for Cd4/cd8 T-Cell Ratio

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....