MCID: CD4008
MIFTS: 21

Cd4/cd8 T-Cell Ratio

Aliases & Classifications for Cd4/cd8 T-Cell Ratio

MalaCards integrated aliases for Cd4/cd8 T-Cell Ratio:

Name: Cd4/cd8 T-Cell Ratio 57

External Ids:

OMIM 57 601083

Summaries for Cd4/cd8 T-Cell Ratio

MalaCards based summary : Cd4/cd8 T-Cell Ratio is related to peritonitis and myelopathy, htlv-1-associated. An important gene associated with Cd4/cd8 T-Cell Ratio is IL16 (Interleukin 16). The drugs Cobicistat and Abacavir have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and b cells.

More information from OMIM: 601083

Related Diseases for Cd4/cd8 T-Cell Ratio

Diseases related to Cd4/cd8 T-Cell Ratio via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 peritonitis 10.2
2 myelopathy, htlv-1-associated 10.1
3 lymphoma, hodgkin, classic 10.1
4 lymphoma, non-hodgkin, familial 10.1
5 aplastic anemia 10.1
6 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.1
7 adult t-cell leukemia 10.1
8 diffuse large b-cell lymphoma 10.1
9 lymphoproliferative syndrome 10.1
10 tropical spastic paraparesis 10.1
11 arthropathy 10.1
12 b-cell lymphoma 10.1
13 t-cell leukemia 10.1
14 htlv-1 associated myelopathy/tropical spastic paraparesis 10.1
15 leukemia, t-cell, chronic 10.1
16 spastic paraparesis 10.1

Graphical network of the top 20 diseases related to Cd4/cd8 T-Cell Ratio:



Diseases related to Cd4/cd8 T-Cell Ratio

Symptoms & Phenotypes for Cd4/cd8 T-Cell Ratio

Clinical features from OMIM:

601083

Drugs & Therapeutics for Cd4/cd8 T-Cell Ratio

Drugs for Cd4/cd8 T-Cell Ratio (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobicistat Approved Phase 4 1004316-88-4
2
Abacavir Approved, Investigational Phase 4 136470-78-5 65140 441300
3
Darunavir Approved Phase 4 206361-99-1, 635728-49-3 213039
4
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
5
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
6
Dolutegravir Approved Phase 4 1051375-16-6 54726191
7
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
8 Anti-Retroviral Agents Phase 4
9 Cytochrome P-450 CYP3A Inhibitors Phase 4
10 Integrase Inhibitors Phase 4
11 Anti-Infective Agents Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Nucleic Acid Synthesis Inhibitors Phase 4
14 HIV Integrase Inhibitors Phase 4
15 Reverse Transcriptase Inhibitors Phase 4
16 Anti-HIV Agents Phase 4
17 Antiviral Agents Phase 4
18
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
19 Lipid Regulating Agents Phase 2
20 Rosuvastatin Calcium Phase 2 147098-20-2
21 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
22 Hypolipidemic Agents Phase 2
23 Calcium, Dietary Phase 2
24 Antimetabolites Phase 2
25 Anticholesteremic Agents Phase 2
26
Metformin Approved Phase 1 657-24-9 4091 14219
27 Hypoglycemic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Is Dual Therapy as Effective as Triple Therapy Regarding CD4+/CD8+ Ratio Recovery and Improvement of Immune Activation and Inflammation in HIV-infected Patients With Consistent Plasma Viral Load Suppression (Tridual) Recruiting NCT03447873 Phase 4 Continue with triple therapy;Switch to DTG + 3TC;Switch to DRV/cobicistat + 3TC
2 Pilot Study of the Impact of Rosuvastatin Administration on Residual Chronic Immune Activation Under Antiretroviral Therapy: CESAR (Crestor En Sus Des AntiRétroviraux) Unknown status NCT01874743 Phase 2 Rosuvastatin 20 mg/day
3 The Effect of Metformin on HIV Reservoir Size in Non-diabetic Antiretroviral Therapy (ART) Treated Participants: the Lilac Study Active, not recruiting NCT02659306 Phase 1 Metformin

Search NIH Clinical Center for Cd4/cd8 T-Cell Ratio

Genetic Tests for Cd4/cd8 T-Cell Ratio

Anatomical Context for Cd4/cd8 T-Cell Ratio

MalaCards organs/tissues related to Cd4/cd8 T-Cell Ratio:

41
T Cells, Lung, B Cells, Lymph Node, Nk Cells, Bone, Bone Marrow

Publications for Cd4/cd8 T-Cell Ratio

Articles related to Cd4/cd8 T-Cell Ratio:

(show top 50) (show all 290)
# Title Authors PMID Year
1
Genetic control of the CD4/CD8 T-cell ratio in humans. 38 8
7489409 1995
2
CD4 and CD8 T lymphocyte inheritance. Evidence for major autosomal recessive genes. 8
10543402 1999
3
The CD4/CD8 ratio: message in a bottle? 8
7489396 1995
4
Genetic control of T-cell subset representation in inbred mice. 8
6606619 1983
5
Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa. 38
31358657 2019
6
Immune Biomarkers in the Prediction of Future Myocardial Infarction in People with HIV. 38
31414117 2019
7
Immunologic Features of Patients With Advanced Hepatocellular Carcinoma Before and During Sorafenib or Anti-programmed Death-1/Programmed Death-L1 Treatment. 38
31295151 2019
8
NK cells in treated HIV-infected children display altered phenotype and function. 38
30735686 2019
9
The evaluation of cellular immune function in elderly patients with systemic lupus erythematosus. 38
29172398 2019
10
Incomplete ART adherence is associated with higher inflammation in individuals who achieved virologic suppression in the START study. 38
31250552 2019
11
Chronic arsenic exposure in drinking water interferes with the balances of T lymphocyte subpopulations as well as stimulates the functions of dendritic cells in vivo. 38
30889423 2019
12
Immunological recovery in T-cell activation after sustained virologic response among HIV positive and HIV negative chronic Hepatitis C patients. 38
30835046 2019
13
Effect of Lactobacillus plantarum IS-10506 on blood lipopolysaccharide level and immune response in HIV-infected children. 38
31341568 2019
14
B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. 38
30896447 2019
15
TCR repertoire intratumor heterogeneity of CD4+ and CD8+ T cells in centers and margins of localized lung adenocarcinomas. 38
30151844 2019
16
Retrospective Study of Factors Potentially Influencing Occurrence of Cough in Slovak Patients with Sarcoidosis. 38
31281552 2019
17
CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age. 38
30686790 2019
18
Effect of low-dose cyclophosphamide, ACTH, and IVIG combination immunotherapy on neuroinflammation in pediatric-onset OMS: A retrospective pilot study. 38
29555260 2018
19
Cytomegalovirus aggravates the autoimmune phenomenon in systemic autoimmune diseases. 38
29704668 2018
20
Reversal of T Cell Exhaustion by the First Donor Lymphocyte Infusion Is Associated with the Persistently Effective Antileukemic Responses in Patients with Relapsed AML after Allo-HSCT. 38
29649617 2018
21
T cells establish and maintain CNS viral infection in HIV-infected humanized mice. 38
29863499 2018
22
Does simplification to dolutegravir-based dual regimens impact on the CD4+/CD8+ T-cell ratio? 38
29698323 2018
23
High-grade anal intraepithelial neoplasia is associated with HIV-1 RNA rectal shedding in virologically suppressed MSM. 38
29547439 2018
24
Alteration of CCR6+CD95+CD4+ naïve T cells in HIV-1 infected patients: Implication for clinical practice. 38
29454646 2018
25
The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques. 38
29553486 2018
26
Analysis of peripheral blood T-cell subsets and regulatory T-cells in multiple myeloma patients. 38
29729703 2018
27
Good's Syndrome-Association of the Late Onset Combined Immunodeficiency with Thymoma: Review of Literature and Case Report. 38
29512373 2018
28
[Modified Cheng's Juanbi Decoction reduces cAMP level of T lymphocytes in peripheral blood and CD4+/CD8+ T cell ratio among rats with adjuvant arthritis]. 38
29673452 2018
29
Age-Dependent Pre-Vaccination Immunity Affects the Immunogenicity of Varicella Zoster Vaccination in Middle-aged Adults. 38
29410671 2018
30
[X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia: report of a family and literature review]. 38
29342998 2018
31
Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA. 38
29364927 2018
32
Galectin-1 Restores Immune Tolerance to Liver Transplantation Through Activation of Hepatic Stellate Cells. 38
30032146 2018
33
High proportion of PD-1-expressing CD4+ T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence. 38
28762530 2017
34
Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health? 38
29095912 2017
35
T-cell regulation in Erythema Nodosum Leprosum. 38
28991896 2017
36
HIV-Infected Children Have Elevated Levels of PD-1+ Memory CD4 T Cells With Low Proliferative Capacity and High Inflammatory Cytokine Effector Functions. 38
28934428 2017
37
A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects. 38
28559274 2017
38
Prediction of graft-versus-host disease: a biomarker panel based on lymphocytes and cytokines. 38
28447161 2017
39
Characteristics of Good's Syndrome in China: A Systematic Review. 38
28639577 2017
40
Th1- and Th17-polarized immune infiltrates in eosinophilic fasciitis-A potential marker for histopathologic distinction from morphea. 38
28393380 2017
41
Japanese herbal medicine-induced pneumonitis: A review of 73 patients. 38
28274529 2017
42
Mixed T Cell Chimerism After Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia Using an Alemtuzumab-Containing Regimen Is Shaped by Persistence of Recipient CD8 T Cells. 38
27816648 2017
43
Rituximab-associated progressive multifocal leukoencephalopathy. 38
28225293 2017
44
Divergent Immunomodulation Capacity of Individual Myelin Peptides-Components of Liposomal Therapeutic against Multiple Sclerosis. 38
29085375 2017
45
Activated CD4+ and CD8+ T Cell Proportions in Multiple Sclerosis Patients. 38
27596006 2016
46
[Intervention of Qingshen Granule for Immune Inflammation of Chronic Renal Failure Patients with Damp-heat Syndrome]. 38
30650283 2016
47
Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size. 38
27630237 2016
48
Can Aidi injection restore cellular immunity and improve clinical efficacy in non-small-cell lung cancer patients treated with platinum-based chemotherapy? A meta-analysis of 17 randomized controlled trials following the PRISMA guidelines. 38
27858864 2016
49
Women With Primary Sjögren Syndrome and With Non-Sjögren Sicca Syndrome Show Similar Vulvar Histopathologic and Immunohistochemical Changes. 38
27532148 2016
50
Chronic Δ(9)-Tetrahydrocannabinol Administration Reduces IgE(+)B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin. 38
27109234 2016

Variations for Cd4/cd8 T-Cell Ratio

Expression for Cd4/cd8 T-Cell Ratio

Search GEO for disease gene expression data for Cd4/cd8 T-Cell Ratio.

Pathways for Cd4/cd8 T-Cell Ratio

GO Terms for Cd4/cd8 T-Cell Ratio

Sources for Cd4/cd8 T-Cell Ratio

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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