MCID: CCL003
MIFTS: 30

Cecal Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cecal Benign Neoplasm

MalaCards integrated aliases for Cecal Benign Neoplasm:

Name: Cecal Benign Neoplasm 12 15 17
Cecal Neoplasms 44 71
Malignant Neoplasm of Cecum 71
Neoplasm of Caecum 12
Cecum Carcinoma 71
Cecum Neoplasm 12
Cecal Neoplasm 17

Classifications:



External Ids:

Disease Ontology 12 DOID:1517
MeSH 44 D002430
NCIt 50 C4433
SNOMED-CT 67 126839008
UMLS 71 C0007528 C0149640 C0153437

Summaries for Cecal Benign Neoplasm

Disease Ontology : 12 An intestinal benign neoplasm that is located in the cecum.

MalaCards based summary : Cecal Benign Neoplasm, also known as cecal neoplasms, is related to cecum adenoma and cecum carcinoma. An important gene associated with Cecal Benign Neoplasm is CHKA (Choline Kinase Alpha), and among its related pathways/superpathways are Gastric cancer and Mitotic G1-G1/S phases. Affiliated tissues include cecum, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cecal Benign Neoplasm

Diseases related to Cecal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 cecum adenoma 29.7 TERT TCHP RBL1 MEN1 CHKA CDKN2A
2 cecum carcinoma 11.2
3 familial retinoblastoma 10.0 RBL1 CDKN2A
4 cerebellar angioblastoma 10.0 TCHP MEN1
5 malignant spiradenoma 10.0 TCHP CDKN2A
6 bowenoid papulosis 9.9 TERT CDKN2A
7 human papillomavirus infectious disease 9.9 TERT CDKN2A
8 spitzoid melanoma 9.9 TERT CDKN2A
9 acral lentiginous melanoma 9.9 TERT CDKN2A
10 intestinal obstruction 9.9
11 ileus 9.9
12 cervical intraepithelial neoplasia 9.9 TERT CDKN2A
13 mucosal melanoma 9.8 TERT CDKN2A
14 ocular melanoma 9.8 TERT CDKN2A
15 childhood medulloblastoma 9.8 TERT CDKN2A
16 lung benign neoplasm 9.8 TERT CDKN2A
17 penile cancer 9.7 TERT CDKN2A
18 lung adenoma 9.7 CDKN2A CDK2
19 parathyroid carcinoma 9.7 TERT MEN1
20 meningioma, familial 9.6 TERT MEN1 CDKN2A
21 nervous system cancer 9.6 RBL1 CDKN2A CDK2
22 gastrointestinal stromal tumor 9.5 MEN1 CDKN2A CDK2
23 laryngeal squamous cell carcinoma 9.5 TERT CDKN2A CDK2
24 li-fraumeni syndrome 9.4 TERT TCHP MEN1 CDKN2A
25 retinal cancer 9.3 TCHP RBL1 CDKN2A CDK2
26 ocular cancer 9.3 TCHP RBL1 CDKN2A CDK2
27 eye disease 9.3 TCHP RBL1 CDKN2A CDK2
28 pheochromocytoma 9.2 TERT MEN1 CDKN2A CDK2
29 melanoma, cutaneous malignant 1 9.2 TERT TCHP CDKN2A CDK2
30 neuroblastoma 9.2 TERT MEN1 CDKN2A CDK2
31 leukemia, acute myeloid 9.2 TERT TCHP CDKN2A CDK2
32 cervical cancer 9.1 TERT CDKN2A CDK2

Comorbidity relations with Cecal Benign Neoplasm via Phenotypic Disease Network (PDN): (show all 13)


Active Peptic Ulcer Disease Appendix Cancer
Ascending Colon Cancer Colon Carcinoma in Situ
Colorectal Cancer Deficiency Anemia
Intestinal Obstruction Intestinal Perforation
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Cecal Benign Neoplasm:



Diseases related to Cecal Benign Neoplasm

Symptoms & Phenotypes for Cecal Benign Neoplasm

GenomeRNAi Phenotypes related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.32 RBL1
2 Decreased viability GR00221-A-2 9.32 CDK2 CHKA RBL1
3 Decreased viability GR00221-A-3 9.32 CDK2
4 Decreased viability GR00221-A-4 9.32 CHKA
5 Decreased viability GR00301-A 9.32 CDK2
6 Decreased viability GR00342-S-2 9.32 CHKA
7 Decreased viability GR00386-A-1 9.32 CHKA
8 Decreased viability GR00402-S-2 9.32 CHKA

MGI Mouse Phenotypes related to Cecal Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 CDK2 CDKN2A CHKA MEN1 RBL1 TCHP
2 endocrine/exocrine gland MP:0005379 9.72 CDK2 CDKN2A MEN1 RBL1 TERT
3 liver/biliary system MP:0005370 9.63 CDK2 CDKN2A CHKA MEN1 RBL1 TERT
4 neoplasm MP:0002006 9.35 CDK2 CDKN2A MEN1 RBL1 TERT
5 reproductive system MP:0005389 9.02 CDK2 CDKN2A MEN1 RBL1 TERT

Drugs & Therapeutics for Cecal Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cecal Benign Neoplasm

Cochrane evidence based reviews: cecal neoplasms

Genetic Tests for Cecal Benign Neoplasm

Anatomical Context for Cecal Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Cecal Benign Neoplasm:

19
Cecum

Publications for Cecal Benign Neoplasm

Articles related to Cecal Benign Neoplasm:

# Title Authors PMID Year
1
[Simultaneous surgery for stomach and cecal neoplasms]. 61
5017849 1972
2
[Radiodiagnosis of cecal neoplasms]. 61
4320011 1970

Variations for Cecal Benign Neoplasm

Expression for Cecal Benign Neoplasm

Search GEO for disease gene expression data for Cecal Benign Neoplasm.

Pathways for Cecal Benign Neoplasm

Pathways related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 TERT CDKN2A CDK2
2
Show member pathways
12.1 RBL1 CDKN2A CDK2
3
Show member pathways
11.89 RBL1 CDKN2A CDK2
4 11.84 TERT CDKN2A CDK2
5 11.74 RBL1 CDKN2A CDK2
6 11.38 RBL1 CDK2
7
Show member pathways
11.36 RBL1 CDK2
8
Show member pathways
11.34 CDKN2A CDK2
9 11.32 RBL1 CDK2
10 11.32 RBL1 CDKN2A CDK2
11 11.28 RBL1 MEN1 CDKN2A CDK2
12 10.36 RBL1 CDK2

GO Terms for Cecal Benign Neoplasm

Cellular components related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome, telomeric region GO:0000781 8.8 TERT MEN1 CDK2

Biological processes related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 9.46 TERT CDKN2A
2 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.43 CDKN2A CDK2
3 Ras protein signal transduction GO:0007265 9.4 CDKN2A CDK2
4 positive regulation of protein binding GO:0032092 9.37 TERT MEN1
5 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.32 RBL1 CDKN2A
6 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.26 MEN1 CDKN2A
7 beta-catenin-TCF complex assembly GO:1904837 9.16 TERT MEN1
8 negative regulation of cellular senescence GO:2000773 8.96 TERT RBL1
9 replicative senescence GO:0090399 8.62 TERT CDKN2A

Sources for Cecal Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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