Cecal Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cecal Benign Neoplasm

MalaCards integrated aliases for Cecal Benign Neoplasm:

Name: Cecal Benign Neoplasm ¹² ¹⁵ ¹⁷

Cecal Neoplasms ⁴⁴ ⁷¹

Malignant Neoplasm of Cecum ⁷¹

Neoplasm of Caecum ¹²

Cecum Carcinoma ⁷¹

Cecum Neoplasm ¹²

Cecal Neoplasm ¹⁷

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1517

MeSH ⁴⁴ D002430

NCIt ⁵⁰ C4433

SNOMED-CT ⁶⁷ 126839008

EFO ¹⁷ EFO_0007197 EFO_0009255

UMLS ⁷¹ C0007528 C0149640 C0153437

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Summaries for Cecal Benign Neoplasm

Disease Ontology : ¹² An intestinal benign neoplasm that is located in the cecum.

MalaCards based summary : Cecal Benign Neoplasm, also known as cecal neoplasms, is related to cecum adenoma and cecum carcinoma. An important gene associated with Cecal Benign Neoplasm is CHKA (Choline Kinase Alpha), and among its related pathways/superpathways are Gastric cancer and Mitotic G1-G1/S phases. Affiliated tissues include cecum, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Cecal Benign Neoplasm

Diseases related to Cecal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

#	Related Disease	Score	Top Affiliating Genes
1	cecum adenoma	29.7	TERT TCHP RBL1 MEN1 CHKA CDKN2A
2	cecum carcinoma	11.2
3	familial retinoblastoma	10.0	RBL1 CDKN2A
4	cerebellar angioblastoma	10.0	TCHP MEN1
5	malignant spiradenoma	10.0	TCHP CDKN2A
6	bowenoid papulosis	9.9	TERT CDKN2A
7	human papillomavirus infectious disease	9.9	TERT CDKN2A
8	spitzoid melanoma	9.9	TERT CDKN2A
9	acral lentiginous melanoma	9.9	TERT CDKN2A
10	intestinal obstruction	9.9
11	ileus	9.9
12	cervical intraepithelial neoplasia	9.9	TERT CDKN2A
13	mucosal melanoma	9.8	TERT CDKN2A
14	ocular melanoma	9.8	TERT CDKN2A
15	childhood medulloblastoma	9.8	TERT CDKN2A
16	lung benign neoplasm	9.8	TERT CDKN2A
17	penile cancer	9.7	TERT CDKN2A
18	lung adenoma	9.7	CDKN2A CDK2
19	parathyroid carcinoma	9.7	TERT MEN1
20	meningioma, familial	9.6	TERT MEN1 CDKN2A
21	nervous system cancer	9.6	RBL1 CDKN2A CDK2
22	gastrointestinal stromal tumor	9.5	MEN1 CDKN2A CDK2
23	laryngeal squamous cell carcinoma	9.5	TERT CDKN2A CDK2
24	li-fraumeni syndrome	9.4	TERT TCHP MEN1 CDKN2A
25	retinal cancer	9.3	TCHP RBL1 CDKN2A CDK2
26	ocular cancer	9.3	TCHP RBL1 CDKN2A CDK2
27	eye disease	9.3	TCHP RBL1 CDKN2A CDK2
28	pheochromocytoma	9.2	TERT MEN1 CDKN2A CDK2
29	melanoma, cutaneous malignant 1	9.2	TERT TCHP CDKN2A CDK2
30	neuroblastoma	9.2	TERT MEN1 CDKN2A CDK2
31	leukemia, acute myeloid	9.2	TERT TCHP CDKN2A CDK2
32	cervical cancer	9.1	TERT CDKN2A CDK2

Comorbidity relations with Cecal Benign Neoplasm via Phenotypic Disease Network (PDN): (show all 13)

Active Peptic Ulcer Disease	Appendix Cancer
Ascending Colon Cancer	Colon Carcinoma in Situ
Colorectal Cancer	Deficiency Anemia
Intestinal Obstruction	Intestinal Perforation
Iron Deficiency Anemia	Paralytic Ileus
Protein-Energy Malnutrition	Rectosigmoid Junction Neoplasm
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Cecal Benign Neoplasm:

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Symptoms & Phenotypes for Cecal Benign Neoplasm

GenomeRNAi Phenotypes related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	9.32	RBL1
2	Decreased viability	GR00221-A-2	9.32	CDK2 CHKA RBL1
3	Decreased viability	GR00221-A-3	9.32	CDK2
4	Decreased viability	GR00221-A-4	9.32	CHKA
5	Decreased viability	GR00301-A	9.32	CDK2
6	Decreased viability	GR00342-S-2	9.32	CHKA
7	Decreased viability	GR00386-A-1	9.32	CHKA
8	Decreased viability	GR00402-S-2	9.32	CHKA

MGI Mouse Phenotypes related to Cecal Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.8	CDK2 CDKN2A CHKA MEN1 RBL1 TCHP
2	endocrine/exocrine gland	MP:0005379	9.72	CDK2 CDKN2A MEN1 RBL1 TERT
3	liver/biliary system	MP:0005370	9.63	CDK2 CDKN2A CHKA MEN1 RBL1 TERT
4	neoplasm	MP:0002006	9.35	CDK2 CDKN2A MEN1 RBL1 TERT
5	reproductive system	MP:0005389	9.02	CDK2 CDKN2A MEN1 RBL1 TERT

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Drugs & Therapeutics for Cecal Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cecal Benign Neoplasm

Cochrane evidence based reviews: cecal neoplasms

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Genetic Tests for Cecal Benign Neoplasm

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Anatomical Context for Cecal Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Cecal Benign Neoplasm:

¹⁹

Cecum

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Publications for Cecal Benign Neoplasm

Articles related to Cecal Benign Neoplasm:

#	Title	Authors	PMID	Year
1	[Simultaneous surgery for stomach and cecal neoplasms]. ⁶¹	Zisman IF...Kukute BG	5017849	1972
2	[Radiodiagnosis of cecal neoplasms]. ⁶¹	Lazecki L	4320011	1970

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Genes for Cecal Benign Neoplasm

Genes related to Cecal Benign Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CHKA	Choline Kinase Alpha	Protein Coding	4.87	DISEASES inferred ¹⁵
2	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	4.62	DISEASES inferred ¹⁵
3	MEN1	Menin 1	Protein Coding	4.18	DISEASES inferred ¹⁵
4	TCHP	Trichoplein Keratin Filament Binding	Protein Coding	3.93	DISEASES inferred ¹⁵
5	TERT	Telomerase Reverse Transcriptase	Protein Coding	3.79	DISEASES inferred ¹⁵
6	CDK2	Cyclin Dependent Kinase 2	Protein Coding	3.77	DISEASES inferred ¹⁵
7	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3.25	DISEASES inferred ¹⁵

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Variations for Cecal Benign Neoplasm

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Expression for Cecal Benign Neoplasm

Search GEO for disease gene expression data for Cecal Benign Neoplasm.

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Pathways for Cecal Benign Neoplasm

Pathways related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.35	TERT CDKN2A CDK2
2	Mitotic G1-G1/S phases ⁶⁵ Show member pathways G1 to S cell cycle control ¹ G1/S Transition ⁶⁵	12.1	RBL1 CDKN2A CDK2
3	Cyclins and Cell Cycle Regulation ⁶³ Show member pathways Cell Cycle Control by BTG Proteins ⁶³ Cyclin D associated events in G1 ⁶⁵ G1 Phase ⁶⁵ G1-S Phase Transition ⁶³ Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes ⁶⁵	11.89	RBL1 CDKN2A CDK2
4	Human T-cell leukemia virus 1 infection ³⁶	11.84	TERT CDKN2A CDK2
5	Viral carcinogenesis ³⁶	11.74	RBL1 CDKN2A CDK2
6	Regulation of nuclear SMAD2/3 signaling ¹	11.38	RBL1 CDK2
7	Cell cycle Cell cycle (generic schema) ²³ Show member pathways Cell cycle Regulation of G1/S transition (part 2) ²³ G0 and Early G1 ⁶⁵ G2 Phase ⁶⁵	11.36	RBL1 CDK2
8	Regulation of TP53 Expression and Degradation ⁶⁵ Show member pathways Regulation of TP53 Degradation ⁶⁵ Regulation of TP53 Expression ⁶⁵	11.34	CDKN2A CDK2
9	E2F transcription factor network ¹	11.32	RBL1 CDK2
10	Cellular senescence (KEGG) ³⁶	11.32	RBL1 CDKN2A CDK2
11	Cell cycle ³⁶ ¹	11.28	RBL1 MEN1 CDKN2A CDK2
12	ID signaling pathway ¹	10.36	RBL1 CDK2

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GO Terms for Cecal Benign Neoplasm

Cellular components related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromosome, telomeric region	GO:0000781	8.8	TERT MEN1 CDK2

Biological processes related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of protein stability	GO:0031647	9.46	TERT CDKN2A
2	regulation of G2/M transition of mitotic cell cycle	GO:0010389	9.43	CDKN2A CDK2
3	Ras protein signal transduction	GO:0007265	9.4	CDKN2A CDK2
4	positive regulation of protein binding	GO:0032092	9.37	TERT MEN1
5	negative regulation of G1/S transition of mitotic cell cycle	GO:2000134	9.32	RBL1 CDKN2A
6	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	9.26	MEN1 CDKN2A
7	beta-catenin-TCF complex assembly	GO:1904837	9.16	TERT MEN1
8	negative regulation of cellular senescence	GO:2000773	8.96	TERT RBL1
9	replicative senescence	GO:0090399	8.62	TERT CDKN2A

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Sources for Cecal Benign Neoplasm

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