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MCID: CCL003
MIFTS: 33

Cecal Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cecal Benign Neoplasm

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MalaCards integrated aliases for Cecal Benign Neoplasm:

Name: Cecal Benign Neoplasm 12 15 17
Cecal Neoplasms 43 71
Malignant Neoplasm of Cecum 71
Neoplasm of Caecum 12
Cecum Carcinoma 71
Cecum Neoplasm 12
Cecal Neoplasm 17

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1517
MeSH 43 D002430
NCIt 49 C4433
SNOMED-CT 67 126839008
UMLS 71 C0007528 C0149640 C0153437
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Summaries for Cecal Benign Neoplasm

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Disease Ontology : 12 An intestinal benign neoplasm that is located in the cecum.

MalaCards based summary : Cecal Benign Neoplasm, also known as cecal neoplasms, is related to cecum adenoma and cecum carcinoma. An important gene associated with Cecal Benign Neoplasm is CHKA (Choline Kinase Alpha), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Regulation of TP53 Activity. The drugs leucovorin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include cecum, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Cecal Benign Neoplasm

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Diseases related to Cecal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 cecum adenoma 29.3 TERT TCHP RBL1 PTEN CHKA CDKN2A
2 cecum carcinoma 11.4
3 mixed oligodendroglioma-astrocytoma 10.0 TERT PTEN
4 thyroid gland follicular carcinoma 10.0 TERT PTEN
5 thyroid tumor 10.0 TERT PTEN
6 ovarian clear cell carcinoma 9.9 TERT PTEN
7 familial retinoblastoma 9.9 RBL1 CDKN2A
8 malignant spiradenoma 9.9 TCHP CDKN2A
9 vulvar seborrheic keratosis 9.8 PTEN CDKN2A
10 bowenoid papulosis 9.8 TERT CDKN2A
11 primary cutaneous b-cell lymphoma 9.8 PTEN CDKN2A
12 adult astrocytic tumour 9.8 PTEN CDKN2A
13 spitzoid melanoma 9.8 TERT CDKN2A
14 peritoneum cancer 9.8 PTEN CDKN2A
15 cervical intraepithelial neoplasia 9.8 TERT CDKN2A
16 gliomatosis cerebri 9.8 PTEN CDKN2A
17 respiratory system benign neoplasm 9.8 PTEN CDKN2A
18 penile disease 9.8 PTEN CDKN2A
19 verrucous carcinoma 9.8 PTEN CDKN2A
20 cystic teratoma 9.8 PTEN CDKN2A
21 mucosal melanoma 9.7 TERT CDKN2A
22 ovarian cystadenocarcinoma 9.7 PTEN CDKN2A
23 reproductive organ benign neoplasm 9.7 PTEN CDKN2A
24 uterine corpus cancer 9.7 PTEN CDKN2A
25 ocular melanoma 9.7 TERT CDKN2A
26 childhood medulloblastoma 9.7 TERT CDKN2A
27 bilateral breast cancer 9.7 PTEN CDKN2A
28 brain stem glioma 9.7 PTEN CDKN2A
29 lung benign neoplasm 9.7 TERT CDKN2A
30 lung adenoma 9.7 CDKN2A CDK2
31 serous cystadenocarcinoma 9.7 PTEN CDKN2A
32 pre-malignant neoplasm 9.7 PTEN CDKN2A
33 sporadic breast cancer 9.6 PTEN CDKN2A
34 skin squamous cell carcinoma 9.6 PTEN CDKN2A
35 endometrial adenocarcinoma 9.6 PTEN CDKN2A
36 in situ carcinoma 9.6 PTEN CDKN2A
37 small cell carcinoma 9.5 PTEN CDKN2A
38 neurofibroma 9.5 PTEN CDKN2A
39 papilloma 9.5 RBL1 PTEN CDKN2A
40 brain glioma 9.5 TERT PTEN
41 cervical adenocarcinoma 9.5 PTEN CDKN2A
42 acral lentiginous melanoma 9.4 TERT PTEN CDKN2A
43 fibrillary astrocytoma 9.4 TERT PTEN CDKN2A
44 giant cell glioblastoma 9.4 TERT PTEN CDKN2A
45 penile cancer 9.4 TERT PTEN CDKN2A
46 gliosarcoma 9.4 TERT PTEN CDKN2A
47 malignant glioma 9.4 TERT PTEN CDKN2A
48 oligodendroglioma 9.4 TERT PTEN CDKN2A
49 melanoma, uveal 9.4 TERT PTEN CDKN2A
50 lynch syndrome 9.4 TERT PTEN CDKN2A

Comorbidity relations with Cecal Benign Neoplasm via Phenotypic Disease Network (PDN): (show all 13)


Active Peptic Ulcer Disease Appendix Cancer
Ascending Colon Cancer Colon Carcinoma in Situ
Colorectal Cancer Deficiency Anemia
Intestinal Obstruction Intestinal Perforation
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Cecal Benign Neoplasm:



Diseases related to Cecal Benign Neoplasm
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Symptoms & Phenotypes for Cecal Benign Neoplasm

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GenomeRNAi Phenotypes related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 CDK2 CDKN2A PTEN
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 CDK2 CDKN2A PTEN TERT
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.23 CDK2

MGI Mouse Phenotypes related to Cecal Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 CDK2 CDKN2A CHKA PTEN RBL1 TCHP
2 endocrine/exocrine gland MP:0005379 9.65 CDK2 CDKN2A PTEN RBL1 TERT
3 liver/biliary system MP:0005370 9.43 CDK2 CDKN2A CHKA PTEN RBL1 TERT
4 neoplasm MP:0002006 9.02 CDK2 CDKN2A PTEN RBL1 TERT
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Drugs & Therapeutics for Cecal Benign Neoplasm

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Drugs for Cecal Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2 58-05-9 6006 143
2
Fluorouracil Approved Phase 2 51-21-8 3385
3
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Repetitive Electrostatic Pressurised Intraperitoneal Aerosol Chemotherapy With Oxaliplatin (ePIPAC-OX) as a Palliative Monotherapy for Isolated Unresectable Colorectal Peritoneal Metastases: Protocol of a Multicentre, Open-label, Single-arm, Phase II Study (CRC-PIPAC) Completed NCT03246321 Phase 2

Search NIH Clinical Center for Cecal Benign Neoplasm

Cochrane evidence based reviews: cecal neoplasms

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Genetic Tests for Cecal Benign Neoplasm

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Anatomical Context for Cecal Benign Neoplasm

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The Foundational Model of Anatomy Ontology organs/tissues related to Cecal Benign Neoplasm:

19
Cecum
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Publications for Cecal Benign Neoplasm

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Articles related to Cecal Benign Neoplasm:

# Title Authors PMID Year
1
[Simultaneous surgery for stomach and cecal neoplasms]. 61
5017849 1972
2
[Radiodiagnosis of cecal neoplasms]. 61
4320011 1970
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Variations for Cecal Benign Neoplasm

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Expression for Cecal Benign Neoplasm

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Search GEO for disease gene expression data for Cecal Benign Neoplasm.
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Pathways for Cecal Benign Neoplasm

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Pathways related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 36
Show member pathways
 12.57 TERT RBL1 PTEN CDK2
2
Regulation of TP53 Activity 65
Show member pathways
 12.52 RBL1 PTEN CDKN2A CDK2
3
Pathways in cancer 36
12.35 TERT PTEN CDKN2A CDK2
4
Glioma 36
Show member pathways
 12.33 PTEN CDKN2A CDK2
5
Mitotic G1-G1/S phases 65
Show member pathways
 12.23 RBL1 CDKN2A CDK2
6
Gastric cancer 36
Show member pathways
 12.22 TERT PTEN CDKN2A CDK2
7
DNA Damage Response 1
Show member pathways
 12.06 PTEN CDKN2A CDK2
8
Cell cycle 36 1
12.03 RBL1 CDKN2A CDK2
9
Cyclins and Cell Cycle Regulation 63
Show member pathways
 12 RBL1 CDKN2A CDK2
10
Viral carcinogenesis 36
11.94 RBL1 CDKN2A CDK2
11
Human T-cell leukemia virus 1 infection 36
11.6 TERT PTEN CDKN2A CDK2
12
Cell cycle Cell cycle (generic schema) 22
Show member pathways
 11.48 RBL1 CDK2
13
Regulation of TP53 Expression and Degradation 65
Show member pathways
 11.44 CDKN2A CDK2
14
E2F transcription factor network 1
11.43 RBL1 CDK2
15
Glioblastoma Multiforme 63
11.38 PTEN CDKN2A CDK2
16
Integrated Cancer Pathway 1
11.19 PTEN CDK2
17
Cellular senescence (KEGG) 36
11.12 RBL1 PTEN CDKN2A CDK2
18
ID signaling pathway 1
10.57 RBL1 CDK2
Sources

GO Terms for Cecal Benign Neoplasm

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Cellular components related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome, telomeric region GO:0000781 8.62 TERT CDK2

Biological processes related to Cecal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.43 RBL1 PTEN CDK2
2 Ras protein signal transduction GO:0007265 9.4 CDKN2A CDK2
3 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.37 PTEN CDKN2A
4 negative regulation of cellular senescence GO:2000773 9.32 TERT RBL1
5 replicative senescence GO:0090399 9.16 TERT CDKN2A
6 regulation of protein stability GO:0031647 9.13 TERT PTEN CDKN2A
7 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 8.8 RBL1 PTEN CDKN2A
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Sources for Cecal Benign Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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