MCID: CCL002
MIFTS: 33

Cecal Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Cecal Disease

MalaCards integrated aliases for Cecal Disease:

Name: Cecal Disease 12 15
Cecal Diseases 45 74
Disorder of Cecum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1518
MeSH 45 D002429
UMLS 74 C0007527

Summaries for Cecal Disease

Disease Ontology : 12 An intestinal disease located in the cecum.

MalaCards based summary : Cecal Disease, also known as cecal diseases, is related to cold agglutinin disease and cryopyrin-associated periodic syndrome. An important gene associated with Cecal Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways is Overview of nanoparticle effects. The drugs Ertapenem and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include appendix, lung and colon.

Wikipedia : 77 The cecum or caecum (/ˈsiːkəm/, plural ceca /ˈsiːkə/; from the Latin caecus meaning blind) is an... more...

Related Diseases for Cecal Disease

Diseases related to Cecal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 cold agglutinin disease 10.4 CRP IL6
2 cryopyrin-associated periodic syndrome 10.4 CRP IL6
3 acute cholangitis 10.4 CRP IL6
4 uremic pruritus 10.3 CRP IL6
5 neutrophilia, hereditary 10.3 CRP IL6
6 spinal disease 10.3 CRP IL6
7 viral pneumonia 10.3 CRP IL6
8 multicentric castleman disease 10.3 CRP IL6
9 castleman disease 10.3 CRP IL6
10 relapsing polychondritis 10.3 CRP IL6
11 central nervous system vasculitis 10.3 CRP IL6
12 subacute thyroiditis 10.3 CRP IL6
13 intussusception 10.3 CRP IL6
14 louse-borne relapsing fever 10.3 CRP IL6
15 pyelitis 10.3 CRP IL6
16 orbital cellulitis 10.3 CRP HCK
17 ischemic heart disease 10.3 CRP IL6
18 mesenteric lymphadenitis 10.3 CRP IL6
19 viral meningitis 10.3 CRP IL6
20 mycoplasma pneumoniae pneumonia 10.3 CRP IL6
21 hypersensitivity reaction type iii disease 10.3 CRP IL6
22 acute orbital inflammation 10.3 CRP HCK
23 intermittent explosive disorder 10.3 CRP IL6
24 intermediate coronary syndrome 10.3 CRP IL6
25 systolic heart failure 10.3 CRP IL6
26 sphenoid sinusitis 10.2 CRP PGRMC1
27 prediabetes syndrome 10.2 CRP IL6
28 acute cystitis 10.2 CRP IL6
29 acute pyelonephritis 10.2 CRP IL6
30 apnea, obstructive sleep 10.2 CRP IL6
31 calcific tendinitis 10.2 CRP CTRC
32 adult-onset still's disease 10.2 CRP IL6
33 olfactory groove meningioma 10.2 CHGA PGRMC1
34 anterior cranial fossa meningioma 10.1 CHGA PGRMC1
35 polyarteritis nodosa 10.1 CRP IL6
36 preterm premature rupture of the membranes 10.1 CRP IL6 PGRMC1
37 angina pectoris 10.1 CRP IL6
38 perinatal necrotizing enterocolitis 9.9 CRP IL6

Graphical network of the top 20 diseases related to Cecal Disease:



Diseases related to Cecal Disease

Symptoms & Phenotypes for Cecal Disease

Drugs & Therapeutics for Cecal Disease

Drugs for Cecal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 237)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 153832-46-3 150610
2
Ropivacaine Approved Phase 4,Phase 1,Phase 2,Not Applicable 84057-95-4 175805 71273
3
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 443-48-1 4173
4
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
6
Ofloxacin Approved Phase 4,Phase 2,Not Applicable 82419-36-1 4583
7
Levofloxacin Approved, Investigational Phase 4,Phase 2,Not Applicable 100986-85-4 149096
8
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 38396-39-3, 2180-92-9 2474
9
Ampicillin Approved, Vet_approved Phase 4,Not Applicable 69-53-4 6249
10
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
11
Tigecycline Approved Phase 4,Not Applicable 220620-09-7 5282044
12
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
13
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
14
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
15
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
16
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
17
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
18
Nalbuphine Approved Phase 4 20594-83-6 5311304 5360630
19
Aztreonam Approved Phase 4 78110-38-0 5742832 5362041
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
22 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
26 Anesthetics, Local Phase 4,Phase 1,Phase 2,Not Applicable
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
28 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
29 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
30 Analgesics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
31 Analgesics, Opioid Phase 4,Phase 3
32 Narcotics Phase 4,Phase 3,Phase 1,Phase 2
33 Anti-Infective Agents, Urinary Phase 4,Phase 2,Not Applicable
34 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
35 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Not Applicable
36 Renal Agents Phase 4,Phase 2,Not Applicable
37 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
38 Gentamicins Phase 4,Not Applicable
39 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
40 Clavulanic Acids Phase 4,Phase 3,Phase 2,Not Applicable
41 Antirheumatic Agents Phase 4,Not Applicable
42 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
43 Cyclooxygenase 2 Inhibitors Phase 4
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Not Applicable
45 Cyclooxygenase Inhibitors Phase 4,Not Applicable
46 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2,Not Applicable
47 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2,Not Applicable
48 Piperacillin, Tazobactam Drug Combination Phase 4,Not Applicable
49 Anti-Arrhythmia Agents Phase 4
50 Diuretics, Potassium Sparing Phase 4

Interventional clinical trials:

(show top 50) (show all 233)
# Name Status NCT ID Phase Drugs
1 Antibiotics Versus Surgery in Acute Appendicitis Unknown status NCT01421901 Phase 4 Ertapenem
2 Laparoscopic Versus Open Appendectomy Completed NCT02867072 Phase 4
3 Choose the Best Concentration of Ropivacaine on TAP Block for Open Appendectomy in Children Completed NCT03005808 Phase 4 Ropivacaine
4 Appendicectomy Skin Closure Technique: Changing Paradigms (ASC) Completed NCT02625987 Phase 4
5 A Comparison of UGBRS Block and Local Infiltration Completed NCT02352519 Phase 4
6 Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children Completed NCT01678365 Phase 4 ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
7 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
8 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
9 Non Operative Treatment for Acute Appendicitis Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
10 Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon Completed NCT00783016 Phase 4 Morphine
11 Wound Healing After Emergency Appendicectomy Completed NCT00913445 Phase 4
12 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
13 Morphine Analgesia in Patients With Acute Appendicitis Completed NCT00477061 Phase 4 Morphine
14 Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy Recruiting NCT03886896 Phase 4 Lidocaine
15 Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult Recruiting NCT03481517 Phase 4 Bupivacaine
16 A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis Recruiting NCT03380793 Phase 4 morinidazole
17 Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Recruiting NCT02848820 Phase 4 Augmentin + Gentamicin
18 Antibiotic Duration in Post-appendectomy Abscess Not yet recruiting NCT03795194 Phase 4 ampicillin/clavulanate
19 A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis Terminated NCT00236912 Phase 4 levofloxacin; metronidazole
20 Once Daily Metronidazole for Perforated Appendicitis Withdrawn NCT02561117 Phase 4 Metronidazole
21 The Onset Time of Rocuronium in Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
22 Laparoscopic Appendectomy by Multi-port vs Single Port. Unknown status NCT01720082 Phase 3
23 Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Completed NCT02784704 Phase 3 Eravacycline;Meropenem;Placebo
24 Feasibility of Outpatient Appendectomy for Acute Appendicitis Completed NCT01839435 Phase 3
25 Single Incision Versus Conventional Laparoscopic Appendectomy Completed NCT01515293 Phase 3
26 Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis Completed NCT01659983 Phase 3
27 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
28 A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy. Completed NCT01203566 Phase 3
29 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT Completed NCT00913380 Phase 3
30 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
31 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
32 Early Versus Interval Appendectomy for Ruptured Appendicitis in Children Completed NCT00435032 Phase 3
33 Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain Completed NCT00413855 Phase 3
34 The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) Not yet recruiting NCT03688295 Phase 3 Antibiotics
35 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
36 Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Unknown status NCT02789865 Phase 2 Ertapenem, Levofloxacin and Metronidazole
37 Nebulized Analgesia for Laparoscopic Appendectomy Trial Unknown status NCT02624089 Phase 1, Phase 2 Ropivacaine;Normal saline
38 Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer Unknown status NCT00006112 Phase 2 chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
39 Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis Completed NCT03435900 Phase 2 Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o.;Standard antibiotics intravenously
40 The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis Completed NCT03046758 Phase 2 A combination of fosfomycin, metronidazole and GM-CSF i.p.
41 Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy Completed NCT02711449 Phase 2 Methylprednisolone;0.9% Saline
42 Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Completed NCT02664220 Phase 2 Povidone-iodine irrigation
43 Dexamethasone Preoperative for Patients Undergoing Laparoscopy for Suspected Appendicitis Completed NCT02415335 Phase 2 dexamethasone phosphate;Isotonic NaCl
44 Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix Completed NCT01580410 Phase 2 mitomycin C;oxaliplatin;hyperthermic intraperitoneal chemotherapy
45 Laparoscopic Management of Periappendicular Abscess Completed NCT01283815 Phase 2
46 Study of Conservative Versus Surgical Treatment of Appendicitis Completed NCT00469430 Phase 2 cefotaxim and metronidazol
47 Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer Completed NCT00310076 Phase 2 thalidomide
48 The Role of Contrast Enhanced Ultrasound in Appendicitis Recruiting NCT03687502 Phase 2 Sulfur hexafluoride lipid-type A microspheres
49 Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors Recruiting NCT03693846 Phase 2 Nivolumab;Ipilimumab
50 Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy Recruiting NCT03528343 Phase 1, Phase 2 Non-narcotic pain control

Search NIH Clinical Center for Cecal Disease

Cochrane evidence based reviews: cecal diseases

Genetic Tests for Cecal Disease

Anatomical Context for Cecal Disease

MalaCards organs/tissues related to Cecal Disease:

42
Appendix, Lung, Colon, Breast, Skin, Liver, Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Cecal Disease:

20
The Cecum

Publications for Cecal Disease

Variations for Cecal Disease

Expression for Cecal Disease

Search GEO for disease gene expression data for Cecal Disease.

Pathways for Cecal Disease

Pathways related to Cecal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 CRP IL6

GO Terms for Cecal Disease

Biological processes related to Cecal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.43 CHGA CRP IL6
2 acute-phase response GO:0006953 9.32 CRP IL6
3 negative regulation of blood vessel diameter GO:0097756 9.16 CHGA CRP
4 inflammatory response GO:0006954 9.02 CRP HCK IL6 LIAS POLB
5 negative regulation of lipid storage GO:0010888 8.96 CRP IL6

Sources for Cecal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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