MCID: CCL002
MIFTS: 25

Cecal Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Cecal Disease

MalaCards integrated aliases for Cecal Disease:

Name: Cecal Disease 12 15
Cecal Diseases 44 73
Disorder of Cecum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1518
MeSH 44 D002429
UMLS 73 C0007527

Summaries for Cecal Disease

Disease Ontology : 12 An intestinal disease located in the cecum.

MalaCards based summary : Cecal Disease, also known as cecal diseases, is related to common bile duct disease and cold agglutinin disease. An important gene associated with Cecal Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are IL6-mediated signaling events and IL-10 Pathway. The drugs Ertapenem and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include appendix, lung and heart.

Wikipedia : 76 The cecum or caecum (/�?siːk�?m/, plural ceca /�?siːk�?/; from the Latin caecus meaning blind) is an... more...

Related Diseases for Cecal Disease

Diseases related to Cecal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 common bile duct disease 10.2 NODAL STK10
2 cold agglutinin disease 10.2 CRP IL6
3 cryopyrin-associated periodic syndrome 10.2 CRP IL6
4 acute cholangitis 10.2 CRP IL6
5 uremic pruritus 10.2 CRP IL6
6 neutrophilia, hereditary 10.2 CRP IL6
7 spinal disease 10.2 CRP IL6
8 viral pneumonia 10.2 CRP IL6
9 multicentric castleman disease 10.2 CRP IL6
10 castleman disease 10.2 CRP IL6
11 relapsing polychondritis 10.2 CRP IL6
12 central nervous system vasculitis 10.2 CRP IL6
13 subacute thyroiditis 10.2 CRP IL6
14 intussusception 10.2 CRP IL6
15 louse-borne relapsing fever 10.2 CRP IL6
16 orbital cellulitis 10.2 CRP HCK
17 pyelitis 10.2 CRP IL6
18 ischemic heart disease 10.2 CRP IL6
19 mesenteric lymphadenitis 10.2 CRP IL6
20 viral meningitis 10.2 CRP IL6
21 mycoplasma pneumoniae pneumonia 10.2 CRP IL6
22 hypersensitivity reaction type iii disease 10.2 CRP IL6
23 intermittent explosive disorder 10.2 CRP IL6
24 acute orbital inflammation 10.2 CRP HCK
25 intermediate coronary syndrome 10.2 CRP IL6
26 systolic heart failure 10.1 CRP IL6
27 prediabetes syndrome 10.1 CRP IL6
28 cecum adenocarcinoma 10.1 CHGA NODAL
29 acute cystitis 10.1 CRP IL6
30 sphenoid sinusitis 10.1 CRP PGRMC1
31 discrete subaortic stenosis 10.1 NODAL PGRMC1
32 acute pyelonephritis 10.1 CRP IL6
33 apnea, obstructive sleep 10.1 CRP IL6
34 calcific tendinitis 10.1 CRP CTRC
35 olfactory groove meningioma 10.1 CHGA PGRMC1
36 anterior cranial fossa meningioma 10.0 CHGA PGRMC1
37 adult-onset still's disease 10.0 CRP IL6
38 preterm premature rupture of the membranes 10.0 CRP IL6 PGRMC1
39 polyarteritis nodosa 10.0 CRP IL6

Graphical network of the top 20 diseases related to Cecal Disease:



Diseases related to Cecal Disease

Symptoms & Phenotypes for Cecal Disease

Drugs & Therapeutics for Cecal Disease

Drugs for Cecal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 153832-46-3 150610
2
Ropivacaine Approved Phase 4,Phase 1,Phase 2,Not Applicable 84057-95-4 175805 71273
3
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 443-48-1 4173
4
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
5
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
6
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
7
Ampicillin Approved, Vet_approved Phase 4,Not Applicable 69-53-4 6249
8
Tigecycline Approved Phase 4,Not Applicable 220620-09-7 5282044
9
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
10
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
11
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
12
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
13
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
14
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
15
Ofloxacin Approved Phase 4,Phase 2,Not Applicable 82419-36-1 4583
16
Levofloxacin Approved, Investigational Phase 4,Phase 2,Not Applicable 100986-85-4 149096
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Anesthetics, Local Phase 4,Phase 1,Phase 2,Not Applicable
22 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
23 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
26 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
27 Analgesics, Opioid Phase 4,Phase 3
28 Narcotics Phase 4,Phase 3,Phase 1,Phase 2
29 Analgesics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Gentamicins Phase 4,Not Applicable
31 Clavulanic Acids Phase 4,Phase 3,Phase 2,Not Applicable
32 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
33 Cyclooxygenase 2 Inhibitors Phase 4
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Not Applicable
35 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
36 Cyclooxygenase Inhibitors Phase 4,Not Applicable
37 Antirheumatic Agents Phase 4,Not Applicable
38 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2,Not Applicable
39 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2,Not Applicable
40 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
41 Piperacillin, tazobactam drug combination Phase 4,Not Applicable
42 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
43 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Not Applicable
44 Anti-Infective Agents, Urinary Phase 4,Phase 2,Not Applicable
45 Renal Agents Phase 4,Phase 2,Not Applicable
46 Penicillanic Acid Phase 4,Not Applicable
47
Rocuronium Approved Phase 3 119302-91-9, 143558-00-3 441290
48
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
49
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
50
Meropenem Approved, Investigational Phase 3,Not Applicable 119478-56-7 64778 441130

Interventional clinical trials:

(show top 50) (show all 228)
# Name Status NCT ID Phase Drugs
1 Antibiotics Versus Surgery in Acute Appendicitis Unknown status NCT01421901 Phase 4 Ertapenem
2 Laparoscopic Versus Open Appendectomy Completed NCT02867072 Phase 4
3 Choose the Best Concentration of Ropivacaine on TAP Block for Open Appendectomy in Children Completed NCT03005808 Phase 4 Ropivacaine
4 Appendicectomy Skin Closure Technique: Changing Paradigms (ASC) Completed NCT02625987 Phase 4
5 A Comparison of UGBRS Block and Local Infiltration Completed NCT02352519 Phase 4
6 Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children Completed NCT01678365 Phase 4 ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
7 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
8 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
9 Non Operative Treatment for Acute Appendicitis Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
10 Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon Completed NCT00783016 Phase 4 Morphine
11 Wound Healing After Emergency Appendicectomy Completed NCT00913445 Phase 4
12 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
13 Morphine Analgesia in Patients With Acute Appendicitis Completed NCT00477061 Phase 4 Morphine
14 Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult Recruiting NCT03481517 Phase 4 Bupivacaine
15 A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis Recruiting NCT03380793 Phase 4 morinidazole
16 Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Recruiting NCT02848820 Phase 4 Augmentin + Gentamicin
17 Antibiotic Duration in Post-appendectomy Abscess Not yet recruiting NCT03795194 Phase 4 ampicillin/clavulanate
18 A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis Terminated NCT00236912 Phase 4 levofloxacin; metronidazole
19 Once Daily Metronidazole for Perforated Appendicitis Withdrawn NCT02561117 Phase 4 Metronidazole
20 The Onset Time of Rocuronium in Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
21 Laparoscopic Appendectomy by Multi-port vs Single Port. Unknown status NCT01720082 Phase 3
22 Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Completed NCT02784704 Phase 3 Eravacycline;Meropenem;Placebo
23 Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis Completed NCT01659983 Phase 3
24 Feasibility of Outpatient Appendectomy for Acute Appendicitis Completed NCT01839435 Phase 3
25 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
26 Single Incision Versus Conventional Laparoscopic Appendectomy Completed NCT01515293 Phase 3
27 A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy. Completed NCT01203566 Phase 3
28 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT Completed NCT00913380 Phase 3
29 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
30 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
31 Early Versus Interval Appendectomy for Ruptured Appendicitis in Children Completed NCT00435032 Phase 3
32 Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain Completed NCT00413855 Phase 3
33 The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) Not yet recruiting NCT03688295 Phase 3 Antibiotics
34 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
35 Nebulized Analgesia for Laparoscopic Appendectomy Trial Unknown status NCT02624089 Phase 1, Phase 2 Ropivacaine;Normal saline
36 Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer Unknown status NCT00006112 Phase 2 chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
37 Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis Completed NCT03435900 Phase 2 Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o.;Standard antibiotics intravenously
38 The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis Completed NCT03046758 Phase 2 A combination of fosfomycin, metronidazole and GM-CSF i.p.
39 Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy Completed NCT02711449 Phase 2 Methylprednisolone;0.9% Saline
40 Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Completed NCT02664220 Phase 2 Povidone-iodine irrigation
41 Dexamethasone Preoperative for Patients Undergoing Laparoscopy for Suspected Appendicitis Completed NCT02415335 Phase 2 dexamethasone phosphate;Isotonic NaCl
42 Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix Completed NCT01580410 Phase 2 mitomycin C;oxaliplatin;hyperthermic intraperitoneal chemotherapy
43 Laparoscopic Management of Periappendicular Abscess Completed NCT01283815 Phase 2
44 Study of Conservative Versus Surgical Treatment of Appendicitis Completed NCT00469430 Phase 2 cefotaxim and metronidazol
45 Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer Completed NCT00310076 Phase 2 thalidomide
46 The Role of Contrast Enhanced Ultrasound in Appendicitis Recruiting NCT03687502 Phase 2 Sulfur hexafluoride lipid-type A microspheres
47 Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy Recruiting NCT03528343 Phase 1, Phase 2 Non-narcotic pain control
48 LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma Recruiting NCT03287947 Phase 2 nintedanib
49 Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis Recruiting NCT02916134 Phase 2 Antibiotic treatment
50 PIPAC for Peritoneal Metastases of Colorectal Cancer Recruiting NCT03246321 Phase 2

Search NIH Clinical Center for Cecal Disease

Cochrane evidence based reviews: cecal diseases

Genetic Tests for Cecal Disease

Anatomical Context for Cecal Disease

MalaCards organs/tissues related to Cecal Disease:

41
Appendix, Lung, Heart, Lymph Node, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Cecal Disease:

19
The Cecum

Publications for Cecal Disease

Variations for Cecal Disease

Expression for Cecal Disease

Search GEO for disease gene expression data for Cecal Disease.

Pathways for Cecal Disease

Pathways related to Cecal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.73 CRP HCK IL6
2 10.7 IL6 PIK3R4
3 10.23 CRP IL6

GO Terms for Cecal Disease

Biological processes related to Cecal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.56 CRP HCK IL6 LIAS
2 defense response to Gram-positive bacterium GO:0050830 9.33 CHGA CRP IL6
3 negative regulation of blood vessel diameter GO:0097756 8.96 CHGA CRP
4 negative regulation of lipid storage GO:0010888 8.62 CRP IL6

Sources for Cecal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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