MCID: CCL002
MIFTS: 32

Cecal Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Cecal Disease

MalaCards integrated aliases for Cecal Disease:

Name: Cecal Disease 12 15
Cecal Diseases 43 71
Disorder of Cecum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1518
MeSH 43 D002429
UMLS 71 C0007527

Summaries for Cecal Disease

Disease Ontology : 12 An intestinal disease located in the cecum.

MalaCards based summary : Cecal Disease, also known as cecal diseases, is related to chronic duodenal ileus and orbital osteomyelitis. An important gene associated with Cecal Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions and Pathogenic Escherichia coli infection. Affiliated tissues include cecum, liver and appendix.

Wikipedia : 74 The cecum or caecum is a pouch within the peritoneum that is considered to be the beginning of the large... more...

Related Diseases for Cecal Disease

Diseases related to Cecal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 701)
# Related Disease Score Top Affiliating Genes
1 chronic duodenal ileus 10.7 CRP ALB
2 orbital osteomyelitis 10.6 F2 CRP
3 cold agglutinin disease 10.6 IL6 CRP
4 small intestine diverticulitis 10.6 F2 CRP
5 prosthetic joint infection 10.6 IL6 CRP
6 chest wall lipoma 10.6 TTR CEACAM5
7 mixed hepatoblastoma 10.6 SERPINA3 CHGA
8 immature teratoma of ovary 10.6 TTR CEACAM5
9 cardiogenic shock 10.6 IL6 CRP
10 cryopyrin-associated periodic syndrome 10.6 IL6 CRP
11 synovial angioma 10.6 F2 CRP
12 renal pelvis squamous cell carcinoma 10.6 F2 CRP
13 blue toe syndrome 10.6 F2 CRP
14 drug reaction with eosinophilia and systemic symptoms 10.6 TNF CRP
15 non-a-e hepatitis 10.6 F2 ALB
16 antipyrine metabolism 10.6 F2 ALB
17 ovarian mixed germ cell neoplasm 10.6 TTR CEACAM5
18 gastric squamous cell carcinoma 10.6 SERPINA3 CCR6
19 dipetalonemiasis 10.6 GPT ALB
20 klebsiella pneumonia 10.6 CRP CCR6 ALB
21 external ear carcinoma 10.6 CRP CEACAM5
22 aspiration pneumonitis 10.6 SERPINA3 CRP ALB
23 polyclonal hypergammaglobulinemia 10.6 SERPINA3 IL6 CRP
24 external pathological resorption 10.6 TNF IL6
25 vaginal glandular tumor 10.6 CHGA CEACAM5
26 anal neuroendocrine tumor 10.6 SYP SPINK5
27 clostridium difficile colitis 10.6 CRP CCR6 ALB
28 gas gangrene 10.5 SERPINA3 IL6 CRP
29 uremic pruritus 10.5 IL6 CRP
30 hypersensitivity vasculitis 10.5 SERPINA3 CRP ALB
31 scorpion envenomation 10.5 TNF IL6
32 systemic autoimmune disease 10.5 IL6 CRP
33 acute myocarditis 10.5 IL6 H2AC18 CRP
34 xanthogranulomatous pyelonephritis 10.5 SERPINA3 ERVMER34-1
35 actinomycosis 10.5 H2AC18 CRP ALB
36 fournier gangrene 10.5 F2 ALB
37 hepatoportal sclerosis 10.5 GPT F2
38 gastric gastrinoma 10.5 SPINK5 CHGA
39 generalized atherosclerosis 10.5 IL6 CRP ALB
40 lymphocele 10.5 STK10 ERVMER34-1 ALB
41 ureter small cell carcinoma 10.5 SYP CHGA
42 heterophyiasis 10.5 GPT ALB
43 sudden sensorineural hearing loss 10.5 IL6 F2
44 lymphatic system cancer 10.5 SERPINA3 H2AC18 CCR6
45 rheumatoid arthritis interstitial lung disease 10.5 TNF CRP
46 tuberculous peritonitis 10.5 CRP CEACAM5 ALB
47 intracranial embolism 10.5 TTR F2 CRP
48 meckel diverticulum 10.5 SPINK5 CRP CHGA
49 cinca syndrome 10.5 IL6 CRP CCR6
50 mucinous adenofibroma 10.5 SYP CEACAM5

Graphical network of the top 20 diseases related to Cecal Disease:



Diseases related to Cecal Disease

Symptoms & Phenotypes for Cecal Disease

Drugs & Therapeutics for Cecal Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Trial Comparing Irrigation Versus Suction in Laparoscopic Appendectomy for Complicated Acute Appendicitis in Adults Unknown status NCT02688244

Search NIH Clinical Center for Cecal Disease

Cochrane evidence based reviews: cecal diseases

Genetic Tests for Cecal Disease

Anatomical Context for Cecal Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Cecal Disease:

19
Cecum

MalaCards organs/tissues related to Cecal Disease:

40
Liver, Appendix, Heart, Bone, Lung, Eye, Colon

Publications for Cecal Disease

Articles related to Cecal Disease:

# Title Authors PMID Year
1
Disease phenotype at diagnosis in pediatric Crohn's disease: 5-year analyses of the EUROKIDS Registry. 61
22573581 2013
2
Benign solitary cecal ulcer: a condition that mimics plastron appendicitis. 61
21153957 2010
3
[Synchronous intestinal, tonsillar and pulmonary tuberculosis]. 61
7577128 1995
4
Surgical diseases of the equine cecum. 61
2670113 1989
5
CMV colitis mimicking Crohn's disease in a patient with acquired immune deficiency syndrome (AIDS). 61
2821006 1987
6
Amebic peritonitis secondary to amebic liver abscess. 61
7054906 1982
7
Gastrointestinal graft-versus-host disease in man. A clinicopathologic study of the rectal biopsy. 61
44107 1979
8
[Observations on the differential radiologic diagnosis of vegetative ileo-cecal diseases]. 61
5973692 1966

Variations for Cecal Disease

Expression for Cecal Disease

Search GEO for disease gene expression data for Cecal Disease.

Pathways for Cecal Disease

GO Terms for Cecal Disease

Cellular components related to Cecal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 TTR STK10 SERPINA3 LRG1 H2AC18 GPT
2 extracellular space GO:0005615 9.73 TTR TNF SPARCL1 SERPINA3 LRG1 IL6
3 extracellular region GO:0005576 9.47 TTR TNF SPINK5 SPARCL1 SERPINA3 LRG1

Biological processes related to Cecal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 TNF SERPINA3 IL6 CXCL8 CRP
2 humoral immune response GO:0006959 9.61 TNF IL6 CCR6
3 defense response to Gram-positive bacterium GO:0050830 9.56 TNF IL6 CRP CHGA
4 cellular protein metabolic process GO:0044267 9.55 TTR SPARCL1 IL6 F2 ALB
5 positive regulation of JAK-STAT cascade GO:0046427 9.5 TNF IL6 F2
6 negative regulation of blood vessel diameter GO:0097756 9.46 CRP CHGA
7 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900738 9.37 F2 CHGA
8 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
9 acute-phase response GO:0006953 8.92 SERPINA3 IL6 F2 CRP

Molecular functions related to Cecal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 TTR TNF SYP STK10 CRP CEACAM5

Sources for Cecal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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