MCID: CCM001
MIFTS: 38

Cecum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cecum Adenocarcinoma

MalaCards integrated aliases for Cecum Adenocarcinoma:

Name: Cecum Adenocarcinoma 12 15
Adenocarcinoma of Cecum 12 73
Cecal Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3039
NCIt 50 C5543
UMLS 73 C1332866

Summaries for Cecum Adenocarcinoma

Disease Ontology : 12 A cecum carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Cecum Adenocarcinoma, also known as adenocarcinoma of cecum, is related to cystadenoma and nasal cavity cancer, and has symptoms including fever and abdominal pain. An important gene associated with Cecum Adenocarcinoma is HMX2 (H6 Family Homeobox 2), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Endometrial cancer. Affiliated tissues include lung, bone and colon, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cellular

Related Diseases for Cecum Adenocarcinoma

Diseases related to Cecum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 cystadenoma 30.1 CHGA KRT20 KRT7
2 nasal cavity cancer 10.3 CDX2 KRT7
3 bladder lymphoma 10.3 KRT20 KRT7
4 papillary serous adenocarcinoma 10.3 KRT20 KRT7
5 bile duct cystadenocarcinoma 10.3 KRT20 KRT7
6 bile duct adenoma 10.3 KRT20 KRT7
7 meibomian cyst 10.3 KRT20 KRT7
8 ovary neuroendocrine neoplasm 10.3 CDX2 KRT7
9 pancreatic serous cystadenoma 10.3 CHGA KRT7
10 eccrine adenocarcinoma 10.3 KRT7 SMUG1
11 mucinous adenofibroma 10.3 CDX2 KRT7
12 anus adenocarcinoma 10.3 CDX2 KRT7
13 cystic basal cell carcinoma 10.3 KRT20 KRT7
14 cervical adenoma malignum 10.3 KRT7 PMS1
15 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
16 transverse colon cancer 10.3 KRT20 KRT7
17 malignant syringoma 10.3 KRT20 KRT7
18 papillary transitional carcinoma 10.3 KRT20 KRT7
19 eyelid carcinoma 10.2 KRT20 KRT7
20 krukenberg carcinoma 10.2 KRT20 KRT7
21 large intestine adenocarcinoma 10.2 KRT20 KRT7
22 linitis plastica 10.2 KRT20 KRT7
23 lung acinar adenocarcinoma 10.2 KRT20 KRT7
24 lung adenoid cystic carcinoma 10.2 HRAS KRAS
25 aggressive digital papillary adenocarcinoma 10.2 HRAS KRAS
26 adenomyoma 10.2 KRT7 MLH1
27 monophasic synovial sarcoma 10.2 KRT7 MLH1
28 ovarian large-cell neuroendocrine carcinoma 10.2 CHGA KRT20
29 malignant spiradenoma 10.2 KRT7 SMUG1
30 appendix adenocarcinoma 10.2 CDX2 KRT20 KRT7
31 glandular cystitis 10.2 CDX2 KRT20 KRT7
32 adenoma of the pancreas 10.2 CHGA KRT20
33 ovarian mucinous adenocarcinoma 10.2 CDX2 KRT20 KRT7
34 thymus adenocarcinoma 10.2 CDX2 KRT20 KRT7
35 gastric diffuse adenocarcinoma 10.2 CDX2 KRT20 KRT7
36 chronic cystitis 10.2 CDX2 KRT20 KRT7
37 vulva adenocarcinoma 10.2 CDX2 KRT20 KRT7
38 rectum adenocarcinoma 10.2 CDX2 KRT20 KRT7
39 mucinous bronchioloalveolar adenocarcinoma 10.2 CDX2 KRT20 KRT7
40 ampulla of vater adenocarcinoma 10.2 CDX2 KRT20 KRT7
41 endocervical adenocarcinoma 10.2 CDX2 KRT20 KRT7
42 cervical adenocarcinoma 10.2 CDX2 KRT20 KRT7
43 ovarian mucinous neoplasm 10.2 CDX2 KRT20 KRT7
44 appendix cancer 10.2 CDX2 KRT20 KRT7
45 prostatic acinar adenocarcinoma 10.2 CDX2 KRT20 KRT7
46 cystic teratoma 10.2 CDX2 KRT20 KRT7
47 cervical mucinous adenocarcinoma 10.2 KRT7 PMS1
48 liver leiomyosarcoma 10.2 CHGA SMUG1
49 duodenum adenocarcinoma 10.2 CDX2 KRAS KRT7
50 cystitis cystica 10.2 CDX2 KRT20 KRT7

Graphical network of the top 20 diseases related to Cecum Adenocarcinoma:



Diseases related to Cecum Adenocarcinoma

Symptoms & Phenotypes for Cecum Adenocarcinoma

UMLS symptoms related to Cecum Adenocarcinoma:


fever, abdominal pain

GenomeRNAi Phenotypes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 CDX2 KRAS MLH1 MSH6 RNGTT

MGI Mouse Phenotypes related to Cecum Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 B2M CDX2 FGF2 KRAS KRT7 MLH1
2 homeostasis/metabolism MP:0005376 10 B2M CDX2 CHGA FGF2 HMX2 HRAS
3 digestive/alimentary MP:0005381 9.8 B2M CDX2 HRAS KRAS MLH1 MSH2
4 mortality/aging MP:0010768 9.73 B2M CDX2 CHGA FGF2 HMX2 HRAS
5 neoplasm MP:0002006 9.32 B2M CDX2 FGF2 HRAS KRAS MLH1

Drugs & Therapeutics for Cecum Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cecum Adenocarcinoma

Genetic Tests for Cecum Adenocarcinoma

Anatomical Context for Cecum Adenocarcinoma

MalaCards organs/tissues related to Cecum Adenocarcinoma:

41
Lung, Bone, Colon, Ovary, Pancreas, Thymus, Appendix

Publications for Cecum Adenocarcinoma

Articles related to Cecum Adenocarcinoma:

# Title Authors Year
1
Cecum adenocarcinoma as the first manifestation of Crohn's disease in a 24-year-old woman: dilemmas in differential diagnosis and management. ( 21457632 )
2010
2
Inferior vena cava obstruction due to cecum adenocarcinoma. ( 17189847 )
2007
3
Minimal change nephrotic syndrome with cecum adenocarcinoma. ( 8861804 )
1996

Variations for Cecum Adenocarcinoma

Expression for Cecum Adenocarcinoma

Search GEO for disease gene expression data for Cecum Adenocarcinoma.

Pathways for Cecum Adenocarcinoma

Pathways related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 HRAS KRAS MLH1 MSH2 MSH6
2
Show member pathways
12.64 HRAS KRAS MLH1 MSH2 MSH6
3
Show member pathways
12.52 CDX2 FGF2 HRAS KRAS MLH1
4
Show member pathways
12.38 FGF2 HRAS KRAS MSH2
5 12.35 FGF2 HRAS KRAS MLH1 MSH2 MSH6
6 11.92 KRAS MLH1 MSH2 MSH6
7 11.77 FGF2 HRAS KRAS NODAL
8
Show member pathways
11.64 FGF2 HRAS KRAS
9 11.52 MLH1 MSH2 MSH6
10 11.29 FGF2 NODAL NT5E
11
Show member pathways
11.25 MLH1 MSH2 MSH6 PMS1
12 11.17 FGF2 HRAS KRAS
13 10.9 MLH1 MSH2 MSH6
14 10.64 HRAS KRAS
15 10.62 HRAS KRAS MLH1 MSH2 MSH6

GO Terms for Cecum Adenocarcinoma

Cellular components related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 MLH1 PMS1
2 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
3 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS1

Biological processes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.96 MLH1 MSH2 MSH6 PMS1 SMUG1
2 positive regulation of cell proliferation GO:0008284 9.85 CDX2 FGF2 HMX2 HRAS KRAS NODAL
3 DNA repair GO:0006281 9.83 MLH1 MSH2 MSH6 PMS1 SMUG1
4 animal organ morphogenesis GO:0009887 9.79 CDX2 FGF2 HRAS
5 Ras protein signal transduction GO:0007265 9.74 FGF2 HRAS KRAS
6 positive regulation of MAP kinase activity GO:0043406 9.7 FGF2 HRAS KRAS
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.67 MLH1 MSH2 MSH6
8 negative regulation of DNA recombination GO:0045910 9.61 MSH2 MSH6
9 determination of adult lifespan GO:0008340 9.61 MSH2 MSH6
10 trophectodermal cell differentiation GO:0001829 9.6 CDX2 NODAL
11 positive regulation of phospholipase C activity GO:0010863 9.59 FGF2 HRAS
12 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 MLH1 MSH2
13 positive regulation of helicase activity GO:0051096 9.58 MSH2 MSH6
14 pyrimidine dimer repair GO:0006290 9.55 MSH2 MSH6
15 response to isolation stress GO:0035900 9.54 HRAS KRAS
16 replication fork arrest GO:0043111 9.51 MSH2 MSH6
17 maintenance of DNA repeat elements GO:0043570 9.48 MSH2 MSH6
18 positive regulation of isotype switching to IgA isotypes GO:0048298 9.46 MLH1 MSH2
19 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 MLH1 MSH2 MSH6
20 meiotic mismatch repair GO:0000710 9.4 MSH2 MSH6
21 isotype switching GO:0045190 9.33 MLH1 MSH2 MSH6
22 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
23 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS1
24 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MLH1 MSH2 MSH6

Molecular functions related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.71 MLH1 MSH2 MSH6 PMS1
2 single-stranded DNA binding GO:0003697 9.61 MLH1 MSH2 PMS1
3 four-way junction DNA binding GO:0000400 9.46 MSH2 MSH6
4 MutLalpha complex binding GO:0032405 9.37 MSH2 MSH6
5 oxidized purine DNA binding GO:0032357 9.32 MSH2 MSH6
6 single thymine insertion binding GO:0032143 9.26 MSH2 MSH6
7 single guanine insertion binding GO:0032142 9.16 MSH2 MSH6
8 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
9 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS1

Sources for Cecum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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