MCID: CCM001
MIFTS: 35

Cecum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cecum Adenocarcinoma

MalaCards integrated aliases for Cecum Adenocarcinoma:

Name: Cecum Adenocarcinoma 12 15
Adenocarcinoma of Cecum 12 73
Cecal Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3039
NCIt 50 C5543
SNOMED-CT 68 413446001
UMLS 73 C1332866

Summaries for Cecum Adenocarcinoma

Disease Ontology : 12 A cecum carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Cecum Adenocarcinoma, also known as adenocarcinoma of cecum, is related to ovary neuroendocrine neoplasm and mucinous adenofibroma, and has symptoms including abdominal pain and fever. An important gene associated with Cecum Adenocarcinoma is HMX2 (H6 Family Homeobox 2), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Endometrial cancer. Related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Cecum Adenocarcinoma

Diseases related to Cecum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 ovary neuroendocrine neoplasm 11.0 CDX2 KRT7
2 mucinous adenofibroma 10.9 CDX2 KRT7
3 anus adenocarcinoma 10.9 CDX2 KRT7
4 cervical adenoma malignum 10.9 KRT7 PMS1
5 cystic basal cell carcinoma 10.9 KRT20 KRT7
6 seminal vesicle adenocarcinoma 10.9 KRT20 KRT7
7 transverse colon cancer 10.9 KRT20 KRT7
8 eyelid neoplasm 10.9 KRT20 KRT7
9 malignant syringoma 10.9 KRT20 KRT7
10 krukenberg carcinoma 10.8 KRT20 KRT7
11 large intestine adenocarcinoma 10.8 KRT20 KRT7
12 linitis plastica 10.8 KRT20 KRT7
13 lung acinar adenocarcinoma 10.8 KRT20 KRT7
14 adenoid squamous cell carcinoma 10.8 KRT20 KRT7
15 cervical mucinous adenocarcinoma 10.8 KRT7 PMS1
16 eccrine sweat gland neoplasm 10.8 KRT20 KRT7
17 malignant spiradenoma 10.8 KRT7 SMUG1
18 epithelial predominant wilms' tumor 10.8 CDX2 KRT7
19 adenoma of the pancreas 10.7 CHGA KRT20
20 appendix adenocarcinoma 10.7 CDX2 KRT20 KRT7
21 glandular cystitis 10.7 CDX2 KRT20 KRT7
22 mucinous bronchioloalveolar adenocarcinoma 10.7 CDX2 KRT20 KRT7
23 ovarian mucinous adenocarcinoma 10.7 CDX2 KRT20 KRT7
24 thymus adenocarcinoma 10.7 CDX2 KRT20 KRT7
25 gastric diffuse adenocarcinoma 10.7 CDX2 KRT20 KRT7
26 chronic cystitis 10.7 CDX2 KRT20 KRT7
27 vulva adenocarcinoma 10.7 CDX2 KRT20 KRT7
28 rectum adenocarcinoma 10.7 CDX2 KRT20 KRT7
29 ampulla of vater adenocarcinoma 10.7 CDX2 KRT20 KRT7
30 endocervical adenocarcinoma 10.7 CDX2 KRT20 KRT7
31 ovarian mucinous neoplasm 10.7 CDX2 KRT20 KRT7
32 cystic teratoma 10.7 CDX2 KRT20 KRT7
33 liver leiomyosarcoma 10.7 CHGA SMUG1
34 cystitis cystica 10.7 CDX2 KRT20 KRT7
35 secretory meningioma 10.7 CDX2 KRT20 KRT7
36 bronchiolo-alveolar adenocarcinoma 10.7 CDX2 KRAS KRT7
37 vulval paget's disease 10.6 KRT20 KRT7
38 sigmoid neoplasm 10.6 HRAS KRAS
39 extraosseous osteosarcoma 10.6 KRT7 SMUG1
40 cervical adenocarcinoma 10.6 CDX2 KRT20 KRT7
41 bile duct cystadenocarcinoma 10.6 KRT20 KRT7
42 bile duct carcinoma 10.6 CDX2 KRT20 KRT7
43 apocrine adenoma 10.6 HRAS KRAS
44 cellular ependymoma 10.6 CHGA SMUG1
45 gallbladder small cell carcinoma 10.6 CHGA SMUG1
46 gastric tubular adenocarcinoma 10.6 CDX2 CHGA KRT7
47 intrahepatic cholangiocarcinoma 10.6 CDX2 KRAS KRT7
48 ovarian large-cell neuroendocrine carcinoma 10.6 CHGA KRT20 KRT7
49 villous adenoma 10.6 CDX2 KRAS KRT20
50 small cell carcinoma of the bladder 10.6 CHGA KRT20 KRT7

Graphical network of the top 20 diseases related to Cecum Adenocarcinoma:



Diseases related to Cecum Adenocarcinoma

Symptoms & Phenotypes for Cecum Adenocarcinoma

UMLS symptoms related to Cecum Adenocarcinoma:


abdominal pain, fever

MGI Mouse Phenotypes related to Cecum Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 B2M MLH1 CDX2 MSH2 MSH6 FGF2
2 homeostasis/metabolism MP:0005376 10 CDX2 MSH2 CHGA MSH6 FGF2 NODAL
3 digestive/alimentary MP:0005381 9.8 B2M MLH1 CDX2 MSH2 NODAL HRAS
4 mortality/aging MP:0010768 9.73 CDX2 MSH2 CHGA MSH6 FGF2 NODAL
5 neoplasm MP:0002006 9.32 CDX2 MSH2 MSH6 FGF2 HRAS PMS1

Drugs & Therapeutics for Cecum Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cecum Adenocarcinoma

Genetic Tests for Cecum Adenocarcinoma

Anatomical Context for Cecum Adenocarcinoma

Publications for Cecum Adenocarcinoma

Articles related to Cecum Adenocarcinoma:

# Title Authors Year
1
Cecum adenocarcinoma as the first manifestation of Crohn's disease in a 24-year-old woman: dilemmas in differential diagnosis and management. ( 21457632 )
2010
2
Inferior vena cava obstruction due to cecum adenocarcinoma. ( 17189847 )
2007
3
Minimal change nephrotic syndrome with cecum adenocarcinoma. ( 8861804 )
1996

Variations for Cecum Adenocarcinoma

Expression for Cecum Adenocarcinoma

Search GEO for disease gene expression data for Cecum Adenocarcinoma.

Pathways for Cecum Adenocarcinoma

Pathways related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 HRAS KRAS MLH1 MSH2 MSH6
2
Show member pathways
12.62 HRAS KRAS MLH1 MSH2 MSH6
3
Show member pathways
12.5 CDX2 FGF2 HRAS KRAS MLH1
4
Show member pathways
12.37 FGF2 HRAS KRAS MSH2
5 12.15 FGF2 HRAS KRAS MLH1 MSH2 MSH6
6 11.89 KRAS MLH1 MSH2 MSH6
7 11.7 FGF2 HRAS KRAS NODAL
8
Show member pathways
11.63 FGF2 HRAS KRAS
9 11.5 MLH1 MSH2 MSH6
10 11.26 FGF2 NODAL NT5E
11 11.12 FGF2 HRAS KRAS
12
Show member pathways
10.92 MLH1 MSH2 MSH6 PMS1
13 10.79 MLH1 MSH2 MSH6
14 10.62 HRAS KRAS

GO Terms for Cecum Adenocarcinoma

Cellular components related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 MLH1 PMS1
2 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
3 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS1

Biological processes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.96 MLH1 MSH2 MSH6 PMS1 SMUG1
2 positive regulation of cell proliferation GO:0008284 9.85 CDX2 FGF2 HMX2 HRAS KRAS NODAL
3 DNA repair GO:0006281 9.83 MLH1 MSH2 MSH6 PMS1 SMUG1
4 Ras protein signal transduction GO:0007265 9.75 FGF2 HRAS KRAS
5 positive regulation of MAP kinase activity GO:0043406 9.71 FGF2 HRAS KRAS
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.67 MLH1 MSH2 MSH6
7 anterior/posterior axis specification GO:0009948 9.6 CDX2 NODAL
8 trophectodermal cell differentiation GO:0001829 9.59 CDX2 NODAL
9 determination of adult lifespan GO:0008340 9.58 MSH2 MSH6
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.57 MLH1 MSH2
11 response to isolation stress GO:0035900 9.55 HRAS KRAS
12 positive regulation of helicase activity GO:0051096 9.52 MSH2 MSH6
13 negative regulation of DNA recombination GO:0045910 9.51 MSH2 MSH6
14 maintenance of DNA repeat elements GO:0043570 9.48 MSH2 MSH6
15 positive regulation of isotype switching to IgA isotypes GO:0048298 9.46 MLH1 MSH2
16 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 MLH1 MSH2 MSH6
17 meiotic mismatch repair GO:0000710 9.4 MSH2 MSH6
18 isotype switching GO:0045190 9.33 MLH1 MSH2 MSH6
19 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
20 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS1
21 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MLH1 MSH2 MSH6

Molecular functions related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.73 MLH1 MSH2 MSH6 PMS1
2 double-stranded DNA binding GO:0003690 9.67 CDX2 MSH2 MSH6
3 single-stranded DNA binding GO:0003697 9.63 MLH1 MSH2 PMS1
4 four-way junction DNA binding GO:0000400 9.48 MSH2 MSH6
5 oxidized purine DNA binding GO:0032357 9.4 MSH2 MSH6
6 MutLalpha complex binding GO:0032405 9.37 MSH2 MSH6
7 single guanine insertion binding GO:0032142 9.32 MSH2 MSH6
8 single base insertion or deletion binding GO:0032138 9.26 MSH2 MSH6
9 single thymine insertion binding GO:0032143 9.16 MSH2 MSH6
10 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
11 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS1

Sources for Cecum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....