MCID: CCM001
MIFTS: 37

Cecum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cecum Adenocarcinoma

MalaCards integrated aliases for Cecum Adenocarcinoma:

Name: Cecum Adenocarcinoma 12 15 17
Adenocarcinoma of Cecum 74
Cecal Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3039
NCIt 51 C5543
UMLS 74 C1332866

Summaries for Cecum Adenocarcinoma

Disease Ontology : 12 A cecum carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Cecum Adenocarcinoma, also known as adenocarcinoma of cecum, is related to cystadenoma and medulloepithelioma, and has symptoms including fever and abdominal pain. An important gene associated with Cecum Adenocarcinoma is HMX2 (H6 Family Homeobox 2), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Endometrial cancer. Affiliated tissues include lung, colon and appendix, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism

Related Diseases for Cecum Adenocarcinoma

Diseases related to Cecum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 cystadenoma 30.1 CHGA KRT20 KRT7
2 medulloepithelioma 10.5 KRT20 KRT7
3 glycogen-rich clear cell breast carcinoma 10.5 KRT20 KRT7
4 ovary neuroendocrine neoplasm 10.4 CDX2 KRT7
5 pulmonary sclerosing hemangioma 10.4 CHGA KRT7
6 cervical adenoma malignum 10.4 KRT7 PMS1
7 mucinous adenofibroma 10.4 CDX2 KRT7
8 anus adenocarcinoma 10.4 CDX2 KRT7
9 cystic basal cell carcinoma 10.4 KRT20 KRT7
10 seminal vesicle adenocarcinoma 10.4 KRT20 KRT7
11 transverse colon cancer 10.4 KRT20 KRT7
12 cervical mucinous adenocarcinoma 10.4 KRT7 PMS1
13 malignant syringoma 10.4 KRT20 KRT7
14 papillary transitional carcinoma 10.4 KRT20 KRT7
15 eyelid carcinoma 10.4 KRT20 KRT7
16 krukenberg carcinoma 10.4 KRT20 KRT7
17 large intestine adenocarcinoma 10.4 KRT20 KRT7
18 linitis plastica 10.4 KRT20 KRT7
19 lung acinar adenocarcinoma 10.4 KRT20 KRT7
20 epithelial predominant wilms' tumor 10.4 CDX2 KRT7
21 secondary hypertrophic osteoarthropathy 10.3 HRAS KRAS
22 adenoid squamous cell carcinoma 10.3 KRT20 KRT7
23 cecal benign neoplasm 10.3 HMX2 KRT7 PMS1
24 intratubular embryonal carcinoma 10.3 KRT20 KRT7
25 ovarian large-cell neuroendocrine carcinoma 10.3 CHGA KRT20
26 vulval paget's disease 10.3 KRT20 KRT7
27 gallbladder small cell carcinoma 10.3 CHGA KRT7
28 bile duct cystadenocarcinoma 10.3 KRT20 KRT7
29 nasal cavity cancer 10.3 CDX2 KRT7
30 sigmoid neoplasm 10.3 HRAS KRAS
31 bile duct adenoma 10.3 KRT20 KRT7
32 appendix adenocarcinoma 10.3 CDX2 KRT20 KRT7
33 glandular cystitis 10.3 CDX2 KRT20 KRT7
34 ovarian mucinous adenocarcinoma 10.3 CDX2 KRT20 KRT7
35 thymus adenocarcinoma 10.3 CDX2 KRT20 KRT7
36 gastric diffuse adenocarcinoma 10.3 CDX2 KRT20 KRT7
37 chronic cystitis 10.3 CDX2 KRT20 KRT7
38 apocrine adenoma 10.3 HRAS KRAS
39 vulva adenocarcinoma 10.3 CDX2 KRT20 KRT7
40 rectum adenocarcinoma 10.3 CDX2 KRT20 KRT7
41 mucinous bronchioloalveolar adenocarcinoma 10.3 CDX2 KRT20 KRT7
42 ampulla of vater adenocarcinoma 10.3 CDX2 KRT20 KRT7
43 fibroepithelial basal cell carcinoma 10.3 CHGA KRT20
44 endocervical adenocarcinoma 10.3 CDX2 KRT20 KRT7
45 cervical adenocarcinoma 10.3 CDX2 KRT20 KRT7
46 ovarian mucinous neoplasm 10.3 CDX2 KRT20 KRT7
47 appendix cancer 10.3 CDX2 KRT20 KRT7
48 prostatic acinar adenocarcinoma 10.3 CDX2 KRT20 KRT7
49 duodenum adenocarcinoma 10.3 CDX2 KRAS KRT7
50 cystic teratoma 10.3 CDX2 KRT20 KRT7

Graphical network of the top 20 diseases related to Cecum Adenocarcinoma:



Diseases related to Cecum Adenocarcinoma

Symptoms & Phenotypes for Cecum Adenocarcinoma

UMLS symptoms related to Cecum Adenocarcinoma:


fever, abdominal pain

GenomeRNAi Phenotypes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 CDX2 KRAS MLH1 MSH6 RNGTT

MGI Mouse Phenotypes related to Cecum Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 B2M CDX2 CHGA FGF2 HMX2 HRAS
2 neoplasm MP:0002006 9.61 B2M CDX2 FGF2 HRAS KRAS MLH1
3 renal/urinary system MP:0005367 9.1 CHGA HMX2 HRAS KRAS KRT7 NT5E

Drugs & Therapeutics for Cecum Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cecum Adenocarcinoma

Genetic Tests for Cecum Adenocarcinoma

Anatomical Context for Cecum Adenocarcinoma

MalaCards organs/tissues related to Cecum Adenocarcinoma:

42
Lung, Colon, Appendix, Ovary, Bone, Prostate, Bone Marrow

Publications for Cecum Adenocarcinoma

Articles related to Cecum Adenocarcinoma:

# Title Authors Year
1
Cecum adenocarcinoma as the first manifestation of Crohn's disease in a 24-year-old woman: dilemmas in differential diagnosis and management. ( 21457632 )
2010
2
Inferior vena cava obstruction due to cecum adenocarcinoma. ( 17189847 )
2007
3
Minimal change nephrotic syndrome with cecum adenocarcinoma. ( 8861804 )
1996

Variations for Cecum Adenocarcinoma

Expression for Cecum Adenocarcinoma

Search GEO for disease gene expression data for Cecum Adenocarcinoma.

Pathways for Cecum Adenocarcinoma

Pathways related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 HRAS KRAS MLH1 MSH2 MSH6
2
Show member pathways
12.6 HRAS KRAS MLH1 MSH2 MSH6
3
Show member pathways
12.47 CDX2 FGF2 HRAS KRAS MLH1
4
Show member pathways
12.36 FGF2 HRAS KRAS MSH2
5 12.36 FGF2 HRAS KRAS MLH1 MSH2 MSH6
6 11.89 KRAS MLH1 MSH2 MSH6
7 11.87 FGF2 HRAS KRAS
8
Show member pathways
11.61 FGF2 HRAS KRAS
9 11.47 MLH1 MSH2 MSH6
10
Show member pathways
11.25 MLH1 MSH2 MSH6 PMS1
11 11.13 FGF2 HRAS KRAS
12 10.9 HRAS KRAS
13 10.9 MLH1 MSH2 MSH6
14 10.84 HRAS KRAS
15 10.62 HRAS KRAS
16 10.62 HRAS KRAS MLH1 MSH2 MSH6

GO Terms for Cecum Adenocarcinoma

Cellular components related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 MLH1 PMS1
2 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
3 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS1

Biological processes related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.96 CDX2 FGF2 HMX2 HRAS KRAS
2 DNA repair GO:0006281 9.91 MLH1 MSH2 MSH6 PMS1
3 negative regulation of neuron apoptotic process GO:0043524 9.79 HRAS KRAS MSH2
4 animal organ morphogenesis GO:0009887 9.77 CDX2 FGF2 HRAS
5 Ras protein signal transduction GO:0007265 9.71 FGF2 HRAS KRAS
6 positive regulation of MAP kinase activity GO:0043406 9.67 FGF2 HRAS KRAS
7 regulation of long-term neuronal synaptic plasticity GO:0048169 9.62 HRAS KRAS
8 negative regulation of DNA recombination GO:0045910 9.6 MSH2 MSH6
9 determination of adult lifespan GO:0008340 9.58 MSH2 MSH6
10 positive regulation of phospholipase C activity GO:0010863 9.58 FGF2 HRAS
11 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 MLH1 MSH2 MSH6
12 positive regulation of isotype switching to IgG isotypes GO:0048304 9.57 MLH1 MSH2
13 positive regulation of helicase activity GO:0051096 9.55 MSH2 MSH6
14 response to isolation stress GO:0035900 9.51 HRAS KRAS
15 maintenance of DNA repeat elements GO:0043570 9.46 MSH2 MSH6
16 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
17 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 MLH1 MSH2 MSH6
18 isotype switching GO:0045190 9.33 MLH1 MSH2 MSH6
19 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
20 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS1
21 pyrimidine dimer repair GO:0006290 9.22 MSH6
22 replication fork arrest GO:0043111 9.18 MSH6
23 meiotic mismatch repair GO:0000710 9.07 MSH6
24 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MLH1 MSH2 MSH6

Molecular functions related to Cecum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.78 MLH1 MSH2 MSH6 PMS1
2 ATPase activity GO:0016887 9.71 MLH1 MSH2 MSH6 PMS1
3 double-stranded DNA binding GO:0003690 9.67 CDX2 MSH2 MSH6
4 four-way junction DNA binding GO:0000400 9.46 MSH2 MSH6
5 single-stranded DNA binding GO:0003697 9.43 MLH1 MSH2
6 MutLalpha complex binding GO:0032405 9.37 MSH2 MSH6
7 oxidized purine DNA binding GO:0032357 9.32 MSH2 MSH6
8 single thymine insertion binding GO:0032143 9.26 MSH2 MSH6
9 single guanine insertion binding GO:0032142 9.16 MSH2 MSH6
10 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
11 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS1

Sources for Cecum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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