MCID: CCM005
MIFTS: 21

Cecum Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cecum Adenoma

MalaCards integrated aliases for Cecum Adenoma:

Name: Cecum Adenoma 12 15
Caecum Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050910

Summaries for Cecum Adenoma

Disease Ontology : 12 A cecal benign neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Cecum Adenoma, also known as caecum adenoma, is related to familial retinoblastoma and cerebellar angioblastoma. An important gene associated with Cecum Adenoma is CHKA (Choline Kinase Alpha), and among its related pathways/superpathways are Gastric cancer and Mitotic G1-G1/S phases. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cecum Adenoma

Diseases related to Cecum Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 familial retinoblastoma 10.0 RBL1 CDKN2A
2 cerebellar angioblastoma 10.0 TCHP MEN1
3 malignant spiradenoma 10.0 TCHP CDKN2A
4 bowenoid papulosis 9.9 TERT CDKN2A
5 human papillomavirus infectious disease 9.9 TERT CDKN2A
6 spitzoid melanoma 9.9 TERT CDKN2A
7 intussusception 9.9
8 adenoma 9.9
9 acral lentiginous melanoma 9.9 TERT CDKN2A
10 cervical intraepithelial neoplasia 9.9 TERT CDKN2A
11 mucosal melanoma 9.8 TERT CDKN2A
12 ocular melanoma 9.8 TERT CDKN2A
13 childhood medulloblastoma 9.8 TERT CDKN2A
14 lung benign neoplasm 9.8 TERT CDKN2A
15 penile cancer 9.7 TERT CDKN2A
16 lung adenoma 9.7 CDKN2A CDK2
17 parathyroid carcinoma 9.7 TERT MEN1
18 meningioma, familial 9.6 TERT MEN1 CDKN2A
19 nervous system cancer 9.6 RBL1 CDKN2A CDK2
20 gastrointestinal stromal tumor 9.5 MEN1 CDKN2A CDK2
21 laryngeal squamous cell carcinoma 9.5 TERT CDKN2A CDK2
22 li-fraumeni syndrome 9.4 TERT TCHP MEN1 CDKN2A
23 retinal cancer 9.3 TCHP RBL1 CDKN2A CDK2
24 ocular cancer 9.3 TCHP RBL1 CDKN2A CDK2
25 eye disease 9.3 TCHP RBL1 CDKN2A CDK2
26 pheochromocytoma 9.2 TERT MEN1 CDKN2A CDK2
27 melanoma, cutaneous malignant 1 9.2 TERT TCHP CDKN2A CDK2
28 neuroblastoma 9.2 TERT MEN1 CDKN2A CDK2
29 leukemia, acute myeloid 9.2 TERT TCHP CDKN2A CDK2
30 cervical cancer 9.1 TERT CDKN2A CDK2
31 cecal benign neoplasm 8.5 TERT TCHP RBL1 MEN1 CHKA CDKN2A

Graphical network of the top 20 diseases related to Cecum Adenoma:



Diseases related to Cecum Adenoma

Symptoms & Phenotypes for Cecum Adenoma

GenomeRNAi Phenotypes related to Cecum Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.32 RBL1
2 Decreased viability GR00221-A-2 9.32 CDK2 CHKA RBL1
3 Decreased viability GR00221-A-3 9.32 CDK2
4 Decreased viability GR00221-A-4 9.32 CHKA
5 Decreased viability GR00301-A 9.32 CDK2
6 Decreased viability GR00342-S-2 9.32 CHKA
7 Decreased viability GR00386-A-1 9.32 CHKA
8 Decreased viability GR00402-S-2 9.32 CHKA

MGI Mouse Phenotypes related to Cecum Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 CDK2 CDKN2A CHKA MEN1 RBL1 TCHP
2 endocrine/exocrine gland MP:0005379 9.72 CDK2 CDKN2A MEN1 RBL1 TERT
3 liver/biliary system MP:0005370 9.63 CDK2 CDKN2A CHKA MEN1 RBL1 TERT
4 neoplasm MP:0002006 9.35 CDK2 CDKN2A MEN1 RBL1 TERT
5 reproductive system MP:0005389 9.02 CDK2 CDKN2A MEN1 RBL1 TERT

Drugs & Therapeutics for Cecum Adenoma

Search Clinical Trials , NIH Clinical Center for Cecum Adenoma

Genetic Tests for Cecum Adenoma

Anatomical Context for Cecum Adenoma

Publications for Cecum Adenoma

Articles related to Cecum Adenoma:

# Title Authors PMID Year
1
Adult colonic intussusception caused by cecum adenoma: successful treatment by emergency laparoscopy: report of a case. 61
17643217 2007

Variations for Cecum Adenoma

Expression for Cecum Adenoma

Search GEO for disease gene expression data for Cecum Adenoma.

Pathways for Cecum Adenoma

Pathways related to Cecum Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 TERT CDKN2A CDK2
2
Show member pathways
12.1 RBL1 CDKN2A CDK2
3
Show member pathways
11.89 RBL1 CDKN2A CDK2
4 11.84 TERT CDKN2A CDK2
5 11.74 RBL1 CDKN2A CDK2
6 11.38 RBL1 CDK2
7
Show member pathways
11.36 RBL1 CDK2
8
Show member pathways
11.34 CDKN2A CDK2
9 11.32 RBL1 CDK2
10 11.32 RBL1 CDKN2A CDK2
11 11.28 RBL1 MEN1 CDKN2A CDK2
12 10.36 RBL1 CDK2

GO Terms for Cecum Adenoma

Cellular components related to Cecum Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome, telomeric region GO:0000781 8.8 TERT MEN1 CDK2

Biological processes related to Cecum Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 9.46 TERT CDKN2A
2 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.43 CDKN2A CDK2
3 Ras protein signal transduction GO:0007265 9.4 CDKN2A CDK2
4 positive regulation of protein binding GO:0032092 9.37 TERT MEN1
5 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.32 RBL1 CDKN2A
6 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.26 MEN1 CDKN2A
7 beta-catenin-TCF complex assembly GO:1904837 9.16 TERT MEN1
8 negative regulation of cellular senescence GO:2000773 8.96 TERT RBL1
9 replicative senescence GO:0090399 8.62 TERT CDKN2A

Sources for Cecum Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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