MCID: CCM005
MIFTS: 23

Cecum Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cecum Adenoma

MalaCards integrated aliases for Cecum Adenoma:

Name: Cecum Adenoma 12 15
Caecum Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050910

Summaries for Cecum Adenoma

Disease Ontology : 12 A cecal benign neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Cecum Adenoma, also known as caecum adenoma, is related to neurofibromatosis, type iv, of riccardi and thyroid tumor. An important gene associated with Cecum Adenoma is CHKA (Choline Kinase Alpha), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Regulation of TP53 Activity. Affiliated tissues include colon, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Cecum Adenoma

Diseases related to Cecum Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type iv, of riccardi 10.0 TCHP PTEN
2 thyroid tumor 10.0 TERT PTEN
3 prostate squamous cell carcinoma 10.0 PTEN CDK2
4 anus benign neoplasm 9.9 CHKA CDKN2A
5 intussusception 9.9
6 adenoma 9.9
7 ovarian clear cell carcinoma 9.9 TERT PTEN
8 familial retinoblastoma 9.9 RBL1 CDKN2A
9 vulvar seborrheic keratosis 9.8 PTEN CDKN2A
10 bowenoid papulosis 9.8 TERT CDKN2A
11 primary cutaneous b-cell lymphoma 9.8 PTEN CDKN2A
12 cervical mucinous adenocarcinoma 9.8 PTEN CDKN2A
13 adult astrocytic tumour 9.8 PTEN CDKN2A
14 cervical intraepithelial neoplasia 9.8 TERT CDKN2A
15 gliomatosis cerebri 9.8 PTEN CDKN2A
16 respiratory system benign neoplasm 9.8 PTEN CDKN2A
17 verrucous carcinoma 9.8 PTEN CDKN2A
18 mucosal melanoma 9.8 TERT CDKN2A
19 peritoneal mesothelioma 9.8 PTEN CDKN2A
20 bilateral breast cancer 9.8 PTEN CDKN2A
21 cystic teratoma 9.8 PTEN CDKN2A
22 uterine corpus cancer 9.7 PTEN CDKN2A
23 vulva cancer 9.7 PTEN CDKN2A
24 ovarian cystadenocarcinoma 9.7 PTEN CDKN2A
25 oropharynx cancer 9.7 PTEN CDKN2A
26 childhood medulloblastoma 9.7 TERT CDKN2A
27 neurofibroma 9.7 PTEN CDKN2A
28 lung benign neoplasm 9.7 TERT CDKN2A
29 pre-malignant neoplasm 9.7 PTEN CDKN2A
30 giant cell glioblastoma 9.6 PTEN CDKN2A
31 ocular melanoma 9.6 TERT CDKN2A
32 endometrial adenocarcinoma 9.6 PTEN CDKN2A
33 sporadic breast cancer 9.6 PTEN CDKN2A
34 skin squamous cell carcinoma 9.6 PTEN CDKN2A
35 small cell carcinoma 9.5 PTEN CDKN2A
36 papilloma 9.5 RBL1 PTEN CDKN2A
37 in situ carcinoma 9.5 PTEN CDKN2A
38 acral lentiginous melanoma 9.4 TERT PTEN CDKN2A
39 fibrillary astrocytoma 9.4 TERT PTEN CDKN2A
40 tongue cancer 9.4 TERT PTEN CDKN2A
41 gliosarcoma 9.4 TERT PTEN CDKN2A
42 malignant glioma 9.4 TERT PTEN CDKN2A
43 oligodendroglioma 9.4 TERT PTEN CDKN2A
44 melanoma, uveal 9.4 TERT PTEN CDKN2A
45 gallbladder cancer 9.4 TERT PTEN CDKN2A
46 ovary adenocarcinoma 9.4 PTEN CDKN2A
47 lynch syndrome 9.4 TERT PTEN CDKN2A
48 bladder urothelial carcinoma 9.4 TERT PTEN CDKN2A
49 lung adenoma 9.4 PTEN CDKN2A CDK2
50 suppression of tumorigenicity 12 9.3 PTEN CDKN2A CDK2

Graphical network of the top 20 diseases related to Cecum Adenoma:



Diseases related to Cecum Adenoma

Symptoms & Phenotypes for Cecum Adenoma

GenomeRNAi Phenotypes related to Cecum Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CDK2 CDKN2A PTEN TERT
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CDK2 CDKN2A PTEN TERT

MGI Mouse Phenotypes related to Cecum Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 CDK2 CDKN2A CHKA PTEN RBL1 TCHP
2 endocrine/exocrine gland MP:0005379 9.72 CDK2 CDKN2A PTEN RBL1 TERT
3 liver/biliary system MP:0005370 9.63 CDK2 CDKN2A CHKA PTEN RBL1 TERT
4 neoplasm MP:0002006 9.35 CDK2 CDKN2A PTEN RBL1 TERT
5 skeleton MP:0005390 9.02 CDKN2A PTEN RBL1 TCHP TERT

Drugs & Therapeutics for Cecum Adenoma

Search Clinical Trials , NIH Clinical Center for Cecum Adenoma

Genetic Tests for Cecum Adenoma

Anatomical Context for Cecum Adenoma

MalaCards organs/tissues related to Cecum Adenoma:

40
Colon

Publications for Cecum Adenoma

Articles related to Cecum Adenoma:

# Title Authors PMID Year
1
Adult colonic intussusception caused by cecum adenoma: successful treatment by emergency laparoscopy: report of a case. 61
17643217 2007

Variations for Cecum Adenoma

Expression for Cecum Adenoma

Search GEO for disease gene expression data for Cecum Adenoma.

Pathways for Cecum Adenoma

Pathways related to Cecum Adenoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.59 TERT RBL1 PTEN CDK2
2
Show member pathways
12.52 RBL1 PTEN CDKN2A CDK2
3 12.35 TERT PTEN CDKN2A CDK2
4
Show member pathways
12.33 PTEN CDKN2A CDK2
5
Show member pathways
12.23 RBL1 CDKN2A CDK2
6
Show member pathways
12.22 TERT PTEN CDKN2A CDK2
7
Show member pathways
12.06 PTEN CDKN2A CDK2
8 12.03 RBL1 CDKN2A CDK2
9
Show member pathways
12 RBL1 CDKN2A CDK2
10 11.91 RBL1 CDKN2A CDK2
11 11.6 TERT PTEN CDKN2A CDK2
12
Show member pathways
11.48 RBL1 CDK2
13
Show member pathways
11.44 CDKN2A CDK2
14 11.43 RBL1 CDK2
15 11.38 PTEN CDKN2A CDK2
16 11.19 PTEN CDK2
17 11.13 RBL1 PTEN CDKN2A CDK2
18 10.57 RBL1 CDK2

GO Terms for Cecum Adenoma

Cellular components related to Cecum Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome, telomeric region GO:0000781 8.62 TERT CDK2

Biological processes related to Cecum Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.43 RBL1 PTEN CDK2
2 Ras protein signal transduction GO:0007265 9.4 CDKN2A CDK2
3 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.37 PTEN CDKN2A
4 negative regulation of cellular senescence GO:2000773 9.32 TERT RBL1
5 replicative senescence GO:0090399 9.16 TERT CDKN2A
6 regulation of protein stability GO:0031647 9.13 TERT PTEN CDKN2A
7 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 8.8 RBL1 PTEN CDKN2A

Sources for Cecum Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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