MCID: CCM004
MIFTS: 33

Cecum Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cecum Carcinoma

MalaCards integrated aliases for Cecum Carcinoma:

Name: Cecum Carcinoma 12 15 17
Cecum Cancer 12 15
Malignant Neoplasm of Caecum 12
Malignant Tumor of the Cecum 12
Carcinoma of Cecum 12
Caecum Carcinoma 12
Cecal Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1519 DOID:1521
ICD9CM 34 153.4
MeSH 43 D002430
NCIt 49 C3491 C9329
SNOMED-CT 67 93736007
ICD10 32 C18.0
UMLS 71 C0149640 C0153437

Summaries for Cecum Carcinoma

Disease Ontology : 12 A cecum cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

MalaCards based summary : Cecum Carcinoma, also known as cecum cancer, is related to cecum adenocarcinoma and appendix adenocarcinoma. An important gene associated with Cecum Carcinoma is LCOR (Ligand Dependent Nuclear Receptor Corepressor), and among its related pathways/superpathways are Signaling pathways regulating pluripotency of stem cells and MNAR-PELP1 and Estrogen Receptor Interaction. Affiliated tissues include colon, ovary and appendix, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cecum Carcinoma

Diseases related to Cecum Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 cecum adenocarcinoma 30.4 TRIM11 RNGTT RIOK3 RIOK2 RIOK1 PPCDC
2 appendix adenocarcinoma 30.1 KRAS HRAS CEACAM5
3 mucinous adenocarcinoma 29.9 MLH1 KRAS CEACAM5
4 uterine carcinosarcoma 29.6 MSH2 MLH1 KRAS HRAS
5 adenocarcinoma 29.4 MSH2 MLH1 KRAS HRAS CEACAM5
6 rectum cancer 29.3 MSH2 MLH1 KRAS HRAS CEACAM5
7 colorectal adenocarcinoma 29.3 MSH2 MLH1 KRAS HRAS CEACAM5
8 lynch syndrome 28.9 REEP5 MSH2 MLH1 KRAS HRAS
9 cecal benign neoplasm 11.3
10 papillary adenoma 10.5 KRAS HRAS
11 trachea carcinoma in situ 10.5 KRAS HRAS
12 nasal cavity adenocarcinoma 10.4 KRAS HRAS
13 urachal adenocarcinoma 10.4 KRAS CEACAM5
14 immature teratoma of ovary 10.4 KRAS CEACAM5
15 ampulla of vater neoplasm 10.4 KRAS HRAS
16 apocrine adenoma 10.4 KRAS CEACAM5
17 periampullary adenoma 10.4 KRAS HRAS
18 descending colon cancer 10.4 KRAS CEACAM5
19 acneiform dermatitis 10.4 KRAS HRAS
20 mucinous lung adenocarcinoma 10.4 KRAS HRAS
21 wolffian duct adenocarcinoma 10.4 KRAS HRAS
22 appendiceal neoplasm 10.4 KRAS CEACAM5
23 pancreatic intraductal papillary-mucinous neoplasm 10.4 KRAS HRAS
24 adult teratoma 10.4 HRAS CEACAM5
25 schimmelpenning-feuerstein-mims syndrome 10.4 KRAS HRAS
26 tumor of exocrine pancreas 10.3 KRAS HRAS
27 ectomesenchymoma 10.3 MSH2 HRAS
28 jejunal adenocarcinoma 10.3 MLH1 CEACAM5
29 pancreatic acinar cell adenocarcinoma 10.3 KRAS HRAS
30 renal pelvis transitional cell carcinoma 10.3 MSH2 MLH1
31 adenosquamous colon carcinoma 10.3 MSH2 MLH1
32 in situ pulmonary adenocarcinoma 10.3 KRAS HRAS
33 extrahepatic bile duct adenoma 10.3 MSH2 MLH1
34 appendix carcinoid tumor 10.3 MSH2 MLH1
35 core binding factor acute myeloid leukemia 10.3 KRAS HRAS
36 cervical adenoma malignum 10.3 MSH2 MLH1
37 jejunal cancer 10.3 MSH2 MLH1
38 paronychia 10.3 KRAS HRAS
39 signet ring basal cell carcinoma 10.3 KRAS HRAS CEACAM5
40 eccrine papillary adenoma 10.3 KRAS HRAS CEACAM5
41 biliary tract benign neoplasm 10.3 KRAS HRAS CEACAM5
42 ovarian mucinous neoplasm 10.3 KRAS HRAS CEACAM5
43 appendix disease 10.3 KRAS HRAS CEACAM5
44 appendix cancer 10.3 KRAS HRAS CEACAM5
45 bile duct cysts 10.3 KRAS HRAS CEACAM5
46 rectosigmoid cancer 10.3 KRAS HRAS CEACAM5
47 anus cancer 10.2 KRAS HRAS CEACAM5
48 autosomal dominant non-syndromic intellectual disability 8 10.2 MSH2 MLH1
49 mixed cell type cancer 10.2 KRAS HRAS CEACAM5
50 colorectal cancer, hereditary nonpolyposis, type 6 10.2 MSH2 MLH1

Graphical network of the top 20 diseases related to Cecum Carcinoma:



Diseases related to Cecum Carcinoma

Symptoms & Phenotypes for Cecum Carcinoma

GenomeRNAi Phenotypes related to Cecum Carcinoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.93 HRAS KRAS RIOK1
2 Decreased viability GR00106-A-0 9.93 KRAS
3 Decreased viability GR00107-A-1 9.93 RIOK1
4 Decreased viability GR00221-A-1 9.93 HRAS KRAS
5 Decreased viability GR00221-A-2 9.93 HRAS KRAS
6 Decreased viability GR00221-A-3 9.93 HRAS
7 Decreased viability GR00240-S-1 9.93 RIOK1
8 Decreased viability GR00301-A 9.93 KRAS
9 Decreased viability GR00342-S-1 9.93 RIOK1
10 Decreased viability GR00342-S-2 9.93 RIOK1
11 Decreased viability GR00381-A-1 9.93 KRAS RIOK1
12 Decreased viability GR00402-S-2 9.93 HRAS KRAS RIOK1
13 Increased cell migration GR00055-A-3 8.92 HRAS KRAS RIOK1 RIOK2

Drugs & Therapeutics for Cecum Carcinoma

Search Clinical Trials , NIH Clinical Center for Cecum Carcinoma

Genetic Tests for Cecum Carcinoma

Anatomical Context for Cecum Carcinoma

MalaCards organs/tissues related to Cecum Carcinoma:

40
Colon, Ovary, Appendix, Lung, Breast, Lymph Node, Small Intestine

Publications for Cecum Carcinoma

Articles related to Cecum Carcinoma:

(show all 43)
# Title Authors PMID Year
1
Fascioliasis presenting as colon cancer liver metastasis on 18F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report. 61
31528248 2019
2
[A Case of Locally Re-Recurrent Colon Cancer Involving the Iliac Bone That Underwent Curative Resection]. 61
30914603 2019
3
[A Case of Low-Grade Appendiceal Mucinous Neoplasm with Cecum Cancer]. 61
30914600 2019
4
[A Case of Cecum Cancer with Synchronous Adrenal Solitary Metastasis]. 61
30692276 2018
5
[A Case of Cecal Cancer with Liver and Lung Metastases That Maintained Long Stable Disease by TFTD and Bevacizumab Chemotherapy]. 61
30449858 2018
6
[A Case of Liver Metastasis of Colorectal Cancer Undifferentiated from Biliary Cystadenocarcinoma]. 61
30382063 2018
7
[Changes in diameter of superior mesenteric vein and gastrocolic trunk in patients with cecum-ascending colon cancer]. 61
29968246 2018
8
Two Cases of Long-Term Survival of Advanced Colorectal Cancer with Synchronous Lung Metastases Treated with mFOLFOX6/XELOX + Bevacizumab. 61
30283317 2018
9
[A Case of Treated with Laparoscopic Surgery for Intussusception Up to the Splenic Flexion Region Due to Cecum Cancer]. 61
29650919 2018
10
[Two Cases of Laparoscopic Simultaneous Resection for Synchronous Liver Metastasis of Colon Cancer]. 61
29394606 2017
11
Thymic and Mediastinal Lymph Node Metastasis of Colon Cancer. 61
28007263 2017
12
[A Case of Colorectal Cancer with Anaphylactic Shock to Oxaliplatin]. 61
26805295 2015
13
[A Case of Consciousness Disturbance Caused by Hyperammonemia during a mFOLFOX6 Regimen for Metastatic Colon Cancer]. 61
26805297 2015
14
[A case of cecum colon cancer with lymph node metastasis successfully treated with XELOX plus bevacizumab]. 61
25434448 2014
15
Impact of stereotactic body radiotherapy on colorectal cancer with distant metastases. 61
24284831 2014
16
[A case wherein bevacizumab/XELOX combination therapy was remarkably effective for the treatment of extensive dissemination in advanced colon cancer, and the primary lesion could be resected]. 61
24231712 2013
17
Curatively resected isolated inguinal lymph node metastasis from cecum cancer: report of a case. 61
23111463 2013
18
[A case of radiation therapy successfully treated liver and lung tumors arising from postoperative cecum cancer]. 61
20037352 2009
19
Metastasis to the penis from cecum carcinoma. 61
19769661 2009
20
Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G > T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue. 61
18172263 2008
21
Laparotomy wound and anastomotic recurrences after resection for cecum cancer: a case report. 61
18251155 2007
22
Isolated right external iliac lymph node recurrence from a primary cecum carcinoma: report of a case. 61
17472973 2007
23
Adult cecoanal intussusception caused by cecum cancer: report of a case. 61
17713738 2007
24
Abscess and cecum carcinoma in inguinal hernia: case report. 61
17062196 2006
25
Cecum cancer underlying appendicular abscess. Case report and review of literature. 61
16759349 2006
26
Xanthogranulomatous appendicitis. 61
16385379 2005
27
In vivo and in situ detection of colorectal cancer using Fourier transform infrared spectroscopy. 61
15637737 2005
28
Single pancreatic metastasis from a previously resected carcinoma of the cecum: a case report. 61
15165777 2004
29
[A case of spinal infarction related to hepatic arterial infusion chemotherapy]. 61
14619512 2003
30
Metastasis to the breast from cecum carcinoma. Case report and review of the literature. 61
11789750 2001
31
Psoas abscess and cellulitis of the right gluteal region resulting from carcinoma of the cecum. 61
11578067 2001
32
A case of colon cancer recurrence with P-glycoprotein treated by methotrexate, fluorouracil, and leucovorin. 61
10430334 1999
33
Penile metastasis secondary to cecum carcinoma: a case report. 61
9840111 1998
34
[A case of cecum cancer metastasizing to the spleen after right hemicolectomy]. 61
9028141 1997
35
Analysis of vascular anatomy and lymph node metastases warrants radical segmental bowel resection for colon cancer. 61
8943187 1997
36
A transforming growth factor beta type II receptor gene mutation common in sporadic cecum cancer with microsatellite instability. 61
8971166 1996
37
Postoperative lower limb paralysis due to retractors. 61
23839631 1996
38
Antitumor activity of immunoconjugates composed of boanmycin and monoclonal antibody. 61
7528068 1994
39
[Experimental studies on therapeutic effect of rat monoclonal antibody-bleomycin A6 conjugate against human colorectal cancer]. 61
7504390 1993
40
[Carcinoma of the cecum: is early diagnosis possible?]. 61
1463263 1992
41
[Inhibitory effect of bleomycin A6 on human colon cancer xenografts in nude mice]. 61
1714798 1990
42
[Colonic cancer screening with KRYPTO-HAEM SSW. The results in 3015 persons]. 61
6670915 1983
43
[Peliosis hepatis: 2 new cases]. 61
742334 1978

Variations for Cecum Carcinoma

Expression for Cecum Carcinoma

Search GEO for disease gene expression data for Cecum Carcinoma.

Pathways for Cecum Carcinoma

Pathways related to Cecum Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.48 NEUROG1 KRAS HRAS
2 10.68 KRAS HRAS
3 10.6 KRAS HRAS
4 10.26 KRAS HRAS
5 9.74 KRAS HRAS

GO Terms for Cecum Carcinoma

Cellular components related to Cecum Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.96 MSH2 MLH1
2 preribosome, small subunit precursor GO:0030688 8.8 RIOK3 RIOK2 RIOK1

Biological processes related to Cecum Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.7 MSH2 KRAS HRAS
2 ribosome biogenesis GO:0042254 9.61 RIOK3 RIOK2 RIOK1
3 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 KRAS HRAS
4 ribosomal small subunit biogenesis GO:0042274 9.49 RIOK2 RIOK1
5 isotype switching GO:0045190 9.48 MSH2 MLH1
6 somatic hypermutation of immunoglobulin genes GO:0016446 9.46 MSH2 MLH1
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 MSH2 MLH1
8 positive regulation of rRNA processing GO:2000234 9.37 RIOK2 RIOK1
9 response to isolation stress GO:0035900 9.32 KRAS HRAS
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.26 MSH2 MLH1
11 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.96 MSH2 MLH1
13 maturation of SSU-rRNA GO:0030490 8.8 RIOK3 RIOK2 RIOK1

Molecular functions related to Cecum Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MSH2 MLH1
2 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Cecum Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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