Cefuroxime Allergy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cefuroxime Allergy

MalaCards integrated aliases for Cefuroxime Allergy:

Name: Cefuroxime Allergy ¹² ¹⁵

Cephuroxime Allergy ¹²

Zinacef Allergy ¹²

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0040025

SNOMED-CT ⁶⁷ 294542001

UMLS ⁷¹ C0571454

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Summaries for Cefuroxime Allergy

Disease Ontology : ¹² A cephalosporin allergy that has allergic trigger cefuroxime.

MalaCards based summary : Cefuroxime Allergy, also known as cephuroxime allergy, is related to vagus nerve disease and necrotizing gastritis. An important gene associated with Cefuroxime Allergy is ACOT1 (Acyl-CoA Thioesterase 1), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and IL-17 Family Signaling Pathways. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Cefuroxime Allergy

Diseases related to Cefuroxime Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)

#	Related Disease	Score	Top Affiliating Genes
1	vagus nerve disease	10.1	ATP4A ATP12A
2	necrotizing gastritis	10.1	ATP4A ATP12A
3	scalp dermatosis	10.1	ATP4A ATP12A
4	hemangioma of intra-abdominal structure	10.1	ATP4A ATP12A
5	acquired gastric outlet stenosis	10.1	ATP4A ATP12A
6	lingual goiter	10.1	ATP4A ATP12A
7	displacement of cardia through esophageal hiatus	10.1	ATP4A ATP12A
8	bacterial esophagitis	10.1	ATP4A ATP12A
9	cascade stomach	10.1	ATP4A ATP12A
10	benzylpenicillin allergy	10.1	ATP4A ATP12A
11	median arcuate ligament syndrome	10.1	ATP4A ATP12A
12	afferent loop syndrome	10.1	ATP4A ATP12A
13	cervix erosion	10.1	ATP4A ATP12A
14	angiodysplasia of intestine	10.1	ATP4A ATP12A
15	angiodysplasia	10.1	ATP4A ATP12A
16	granulomatous gastritis	10.1	ATP4A ATP12A
17	laryngeal tuberculosis	10.1	ATP4A ATP12A
18	fungal esophagitis	10.1	ATP4A ATP12A
19	dieulafoy lesion	10.1	ATP4A ATP12A
20	esophagus melanoma	10.1	ATP4A ATP12A
21	emphysematous cholecystitis	10.1	ATP4A ATP12A
22	gastric gastrinoma	10.1	ATP4A ATP12A
23	superior mesenteric artery syndrome	10.1	ATP4A ATP12A
24	pneumatosis cystoides intestinalis	10.1	ATP4A ATP12A
25	chronic laryngitis	10.1	ATP4A ATP12A
26	laryngitis	10.1	ATP4A ATP12A
27	peptic ulcer perforation	10.1	ATP4A ATP12A
28	viral laryngitis	10.1	ATP4A ATP12A
29	gastroduodenal crohn's disease	10.1	ATP4A ATP12A
30	polyposis, skin pigmentation, alopecia, and fingernail changes	10.1	ATP4A ATP12A
31	central nervous system origin vertigo	10.1	ATP4A ATP12A
32	rumination disorder	10.1	ATP4A ATP12A
33	internal hemorrhoid	10.1	ATP4A ATP12A
34	hemorrhoid	10.1	ATP4A ATP12A
35	acute laryngitis	10.1	ATP4A ATP12A
36	gastroduodenitis	10.1	ATP4A ATP12A
37	duodenitis	10.1	ATP4A ATP12A
38	chronic intestinal vascular insufficiency	10.1	ATP4A ATP12A
39	barbiturate abuse	10.1	ATP4A ATP12A
40	duodenal gastrinoma	10.1	ATP4A ATP12A
41	gastric dilatation	10.1	ATP4A ATP12A
42	gastric hemangioma	10.1	ATP4A ATP12A
43	blind loop syndrome	10.1	ATP4A ATP12A
44	polycystic echinococcosis	10.1	ATP4A ATP12A
45	diclofenac allergy	10.1	ATP4A ATP12A
46	lymphocytic gastritis	10.1	ATP4A ATP12A
47	x-linked chondrodysplasia punctata 1	10.1	ATP4A ATP12A
48	mediastinitis	10.1	ATP4A ATP12A
49	pancreatic gastrinoma	10.1	ATP4A ATP12A
50	duodenal obstruction	10.1	ATP4A ATP12A

Graphical network of the top 20 diseases related to Cefuroxime Allergy:

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Symptoms & Phenotypes for Cefuroxime Allergy

GenomeRNAi Phenotypes related to Cefuroxime Allergy according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-128	9.28	IL13
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-130	9.28	ATP12A IL13
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-200	9.28	ATP12A
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-29	9.28	ATP12A
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-39	9.28	IL13
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-66	9.28	PTGS2
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-79	9.28	PTGS2
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-9	9.28	ATP12A

MGI Mouse Phenotypes related to Cefuroxime Allergy:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.02	ATP12A ATP4A IL13 IL5 PTGS2

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Drugs & Therapeutics for Cefuroxime Allergy

Search Clinical Trials , NIH Clinical Center for Cefuroxime Allergy

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Genetic Tests for Cefuroxime Allergy

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Anatomical Context for Cefuroxime Allergy

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Publications for Cefuroxime Allergy

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Genes for Cefuroxime Allergy

Genes related to Cefuroxime Allergy (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ACOT1	Acyl-CoA Thioesterase 1	Protein Coding	5.67	DISEASES inferred ¹⁵
2	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	3.49	DISEASES inferred ¹⁵
3	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	3.48	DISEASES inferred ¹⁵
4	IL5	Interleukin 5	Protein Coding	3.43	DISEASES inferred ¹⁵
5	IL13	Interleukin 13	Protein Coding	3.35	DISEASES inferred ¹⁵
6	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	3.3	DISEASES inferred ¹⁵

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Variations for Cefuroxime Allergy

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Expression for Cefuroxime Allergy

Search GEO for disease gene expression data for Cefuroxime Allergy.

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Pathways for Cefuroxime Allergy

Pathways related to Cefuroxime Allergy according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Immune response Fc epsilon RI pathway ²³ Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²³ VEGF signaling pathway ³⁶	12.08	PTGS2 IL5 IL13
2	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	11.47	PTGS2 IL5 IL13
3	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.41	IL5 IL13
4	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.38	PTGS2 IL5
5	Lung fibrosis ¹	11.28	IL5 IL13
6	Ovarian steroidogenesis ³⁶	11.16	PTGS2 ACOT1
7	Interleukin-10 signaling ⁶⁵	11.12	PTGS2 IL13
8	Th2 Differentiation Pathway ⁶⁴	11.07	IL5 IL13
9	Development and heterogeneity of the ILC family ¹	10.83	IL5 IL13
10	Cytokines and Inflammatory Response ¹	10.72	IL5 IL13
11	OX40 Pathway ⁶³	10.57	IL5 IL13
12	IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	9.7	IL5 IL13

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GO Terms for Cefuroxime Allergy

Biological processes related to Cefuroxime Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.63	PTGS2 IL5 IL13
2	cytokine-mediated signaling pathway	GO:0019221	9.54	PTGS2 IL5 IL13
3	positive regulation of smooth muscle cell proliferation	GO:0048661	9.48	PTGS2 IL13
4	potassium ion import across plasma membrane	GO:1990573	9.43	ATP4A ATP12A
5	positive regulation of B cell proliferation	GO:0030890	9.4	IL5 IL13
6	cellular sodium ion homeostasis	GO:0006883	9.32	ATP4A ATP12A
7	positive regulation of immunoglobulin production	GO:0002639	9.26	IL5 IL13
8	sodium ion export across plasma membrane	GO:0036376	9.16	ATP4A ATP12A
9	cellular potassium ion homeostasis	GO:0030007	8.96	ATP4A ATP12A
10	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	8.62	ATP4A ATP12A

Molecular functions related to Cefuroxime Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:0005391	9.16	ATP4A ATP12A
2	potassium-transporting ATPase activity	GO:0008556	8.96	ATP4A ATP12A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP4A ATP12A

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Sources for Cefuroxime Allergy

¹ BioSystems

² BitterDB

³ CDC

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

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⁷⁴ Wikipedia